                         SEQUENCE LISTING

<110>  AERase, Inc.
 
<120>  Arginine Depletion Therapy For Treatment of GAMT Deficiency

<130>  218107-0013-00-WO-594073

<150>  US 62/747,837
<151>  2018-10-19

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  1
gatataccat gggttcttct caccatcatc accaccacag ctctggcgag aacctgtact       60

tccagtctgc gaagagccgt acgatcggca ttattggtgc gccgttctct aaaggtcagc      120

cacgcggtgg tgtggaagag ggtccgacgg ttctgcgtaa ggccggttta ttagaaaagc      180

tgaaagagca ggagtgcgac gttaaggact acggtgactt accattcgcg gacatcccga      240

atgatagccc gttccaaatc gttaagaatc cgcgctctgt gggtaaagca agcgagcagt      300

tagcaggtaa ggtggccgag gtcaagaaaa acggtcgtat tagcctggtt ttaggcggtg      360

atcatagctt agcaattggc tctatctctg gtcatgcccg tgtgcaccca gatttaggtg      420

tcatttgggt tgacgcccat acggatatca atacgccatt aacgaccacc agcggcaatc      480

tgcatggcca gccggttagc ttcttactga aggagctgaa gggtaaaatt ccagatgttc      540

cgggctttag ctgggtcacg ccatgtattt ctgccaagga tatcgtgtac attggcttac      600

gtgacgtcga cccaggtgag cactacatct taaagaccct gggtatcaag tatttcagca      660

tgacggaagt ggaccgctta ggcatcggca aggtgatgga ggagacgctg agctatctgc      720

tgggccgtaa gaaacgtcca atccatctga gcttcgatgt tgacggctta gacccgagct      780

ttacgccagc caccggcacg ccggtcgttg gtggtttaac gtatcgcgaa ggcctgtata      840

tcacggagga aatctataag acgggtttac tgagcggtct ggacattatg gaggttaatc      900

caagcttagg taagacgccg gaagaagtta cccgtaccgt taacacggcg gtcgcgatca      960

cgttagcatg tttcggttta gcccgcgagg gcaaccataa accaattgat tatctgaatc     1020

caccgaagtg aggatccgaa ttcg                                            1044


<210>  2
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  2
gatataccat gggcagcagc catcatcacc accatcacag ctctggtgaa aacttatact       60

tccaaagcgt ccatagcgtc gcagtgattg gtgccccgtt tagccaaggt caaaaacgca      120

agggtgttga acatggtccg gcagcgatcc gcgaagcagg tttaatgaag cgtttaagca      180

gcttaggctg tcacttaaag gatttcggtg atttaagctt tacgccggtc ccaaaggatg      240

atttatacaa taatctgatc gttaacccac gctctgtggg tctggcgaac caggagctgg      300

cggaggtcgt gtctcgtgca gtcagcgacg gttatagctg cgttacgctg ggcggtgatc      360

atagcttagc cattggtacg atttctggtc atgcccgcca ttgcccggat ctgtgtgttg      420

tgtgggttga tgcgcacgcg gatatcaata cgccactgac cacgtctagc ggtaatttac      480

acggccagcc ggttagcttc ttattacgtg agctgcaaga caaggtcccg cagttaccag      540

gcttctcttg gatcaaacca tgtatcagca gcgcatctat tgtctacatt ggcctgcgtg      600

atgtcgaccc accggagcac ttcatcctga agaattatga catccagtat ttcagcatgc      660

gtgacatcga ccgtctgggt atccaaaaag ttatggagcg cacgttcgat ctgttaatcg      720

gcaagcgcca gcgtccgatt cacctgagct ttgacattga cgcctttgac ccgaccctgg      780

ccccagcaac gggcacgcca gtggttggtg gtttaaccta ccgtgagggt atgtatattg      840

cagaagagat ccataatacc ggcctgttat ctgccctgga tctggttgaa gtcaatccgc      900

agctggcaac ctctgaggag gaagcgaaga cgaccgccaa cctggcggtg gacgtcatcg      960

cctcttcttt cggccagacg cgtgaaggtg gccatatcgt gtatgaccaa ttaccaacgc     1020

catctagccc ggacgaatct gagaaccaag cacgtgtccg tatttgagga tccgaattcg     1080


<210>  3
<211>  322
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is either methionine or not present

<400>  3

Xaa Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys 
        35                  40                  45              


Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe 
    50                  55                  60                  


Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu 
65                  70                  75                  80  


Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val 
                85                  90                  95      


Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala 
            100                 105                 110         


Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp 
        115                 120                 125             


Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro 
    130                 135                 140                 


Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro 
145                 150                 155                 160 


Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr 
                165                 170                 175     


Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr 
            180                 185                 190         


Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile 
        195                 200                 205             


Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys 
    210                 215                 220                 


Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe 
225                 230                 235                 240 


Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu 
                245                 250                 255     


Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly 
            260                 265                 270         


Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu 
        275                 280                 285             


Val Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe 
    290                 295                 300                 


Gly Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro 
305                 310                 315                 320 


Pro Lys 
        


<210>  4
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Val His Ser Val Ala Val Ile Gly Ala Pro Phe Ser Gln Gly Gln 
1               5                   10                  15      


Lys Arg Lys Gly Val Glu His Gly Pro Ala Ala Ile Arg Glu Ala Gly 
            20                  25                  30          


Leu Met Lys Arg Leu Ser Ser Leu Gly Cys His Leu Lys Asp Phe Gly 
        35                  40                  45              


Asp Leu Ser Phe Thr Pro Val Pro Lys Asp Asp Leu Tyr Asn Asn Leu 
    50                  55                  60                  


Ile Val Asn Pro Arg Ser Val Gly Leu Ala Asn Gln Glu Leu Ala Glu 
65                  70                  75                  80  


Val Val Ser Arg Ala Val Ser Asp Gly Tyr Ser Cys Val Thr Leu Gly 
                85                  90                  95      


Gly Asp His Ser Leu Ala Ile Gly Thr Ile Ser Gly His Ala Arg His 
            100                 105                 110         


Cys Pro Asp Leu Cys Val Val Trp Val Asp Ala His Ala Asp Ile Asn 
        115                 120                 125             


Thr Pro Leu Thr Thr Ser Ser Gly Asn Leu His Gly Gln Pro Val Ser 
    130                 135                 140                 


Phe Leu Leu Arg Glu Leu Gln Asp Lys Val Pro Gln Leu Pro Gly Phe 
145                 150                 155                 160 


Ser Trp Ile Lys Pro Cys Ile Ser Ser Ala Ser Ile Val Tyr Ile Gly 
                165                 170                 175     


Leu Arg Asp Val Asp Pro Pro Glu His Phe Ile Leu Lys Asn Tyr Asp 
            180                 185                 190         


Ile Gln Tyr Phe Ser Met Arg Asp Ile Asp Arg Leu Gly Ile Gln Lys 
        195                 200                 205             


Val Met Glu Arg Thr Phe Asp Leu Leu Ile Gly Lys Arg Gln Arg Pro 
    210                 215                 220                 


Ile His Leu Ser Phe Asp Ile Asp Ala Phe Asp Pro Thr Leu Ala Pro 
225                 230                 235                 240 


Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Met 
                245                 250                 255     


Tyr Ile Ala Glu Glu Ile His Asn Thr Gly Leu Leu Ser Ala Leu Asp 
            260                 265                 270         


Leu Val Glu Val Asn Pro Gln Leu Ala Thr Ser Glu Glu Glu Ala Lys 
        275                 280                 285             


Thr Thr Ala Asn Leu Ala Val Asp Val Ile Ala Ser Ser Phe Gly Gln 
    290                 295                 300                 


Thr Arg Glu Gly Gly His Ile Val Tyr Asp Gln Leu Pro Thr Pro Ser 
305                 310                 315                 320 


Ser Pro Asp Glu Ser Glu Asn Gln Ala Arg Val Arg Ile 
                325                 330             


