                         SEQUENCE LISTING

<110>  IMMUNOME, INC.
 
<120>  EXOSOME-TARGETING BISPECIFIC ANTIBODIES

<130>  172.0003-WO00

<150>  67/746,862
<151>  2018-10-17

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  1
gactctcctg tgcagcctct ggattcacct tcagtatcca tagcctgaat tgggtccgcc       60

aggctccagg gaagggactg gagtgggttt cgtatattag tagtaacagt actaccatat      120

attacgcaga ctctgtgaag ggccgattca ccatctccag agacaatgcc aaggactccc      180

tgtatctgca aatgaacagc ctcagagacg aggacacggc tgtatattac tgtgcgagag      240

actactactg tactggtggt acctgcttct ttcttcctga cctctggggc cggggagccc      300

tggtcaccgt ctcctcagcc tccaccaagg gcccatcggt cttccccctg gcgc            354


<210>  2
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile His Ser Leu Asn 
1               5                   10                  15      


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile 
            20                  25                  30          


Ser Ser Asn Ser Thr Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
        35                  40                  45              


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Ser Leu Tyr Leu Gln Met 
    50                  55                  60                  


Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
65                  70                  75                  80  


Tyr Tyr Cys Thr Gly Gly Thr Cys Phe Phe Leu Pro Asp Leu Trp Gly 
                85                  90                  95      


Arg Gly Ala Leu Val Thr Val Ser Ser Ala Ser Thr Lys Lys Gly Pro 
            100                 105                 110         


Ser Val Phe Pro Leu Ala 
        115             


<210>  3
<211>  299
<212>  DNA
<213>  Homo sapiens

<400>  3
aagagccacc ctctcctgca gggccagtca gaatatcagc aacttcttag cctggtacca       60

acacaaacct ggccaggctc ccaggctcct catctatgat gcatccatca gggccactgg      120

catcccagcc aggttcagtg gcagtgggtc tgggacagac ttcagtctca ccatcagcag      180

cctggagcct gaagattttg cagtttattt ctgtcagcag cgttacaact ggctcacttt      240

cggcggaggg accaaggtag agatcaaacg aactgtggct gcaccatctg tcttcatct       299


<210>  4
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Ser Asn Phe Leu 
1               5                   10                  15      


Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
            20                  25                  30          


Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
        35                  40                  45              


Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro Glu 
    50                  55                  60                  


Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Tyr Asn Trp Leu Thr Phe 
65                  70                  75                  80  


Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
                85                  90                  95      


Val Phe Ile 
            


<210>  5
<211>  407
<212>  DNA
<213>  Homo sapiens

<400>  5
acaggcgcgc actccgaggt gcagctggtg gagtctgggg gaggcttggt acagcctggg       60

gggtccctga gactctcctg tgcagcctct ggattcacct tcagtatcca tagcctgaat      120

tgggtccgcc aggctccagg gaagggactg gagtgggttt cgtatattag tagtaacagt      180

actaccatat attacgcaga ctctgtgaag ggccgattca ccatctccag agacaatgcc      240

aaggactccc tgtatctgca aatgaacagc ctcagagacg aggacacggc tgtatattac      300

tgtgcgagag actactactg tactggtggt acctgcttct ttcttcctga cctctggggc      360

cggggagccc tggtcaccgt ctcctcagcc tccaccaagg gcccatc                    407


<210>  6
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile His 
            20                  25                  30          


Ser Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Asn Ser Thr Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Cys Thr Gly Gly Thr Cys Phe Phe Leu Pro Asp 
            100                 105                 110         


Leu Trp Gly Arg Gly Ala Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu 
    130                 135 


<210>  7
<211>  346
<212>  DNA
<213>  Homo sapiens

<400>  7
tcagatacct ccggagaaat tgtgttgaca cagtctccag ccaccctgtc tttgtctcca       60

ggggaaagag ccaccctctc ctgcagggcc agtcagaata tcagcaactt cttagcctgg      120

taccaacaca aacctggcca ggctcccagg ctcctcatct atgatgcatc catcagggcc      180

actggcatcc cagccaggtt cagtggcagt gggtctggga cagacttcag tctcaccatc      240

agcagcctgg agcctgaaga ttttgcagtt tatttctgtc agcagcgtta caactggctc      300

actttcggcg gagggaccaa ggtagagatc aaacgaactg tggctg                     346


<210>  8
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Ser Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Tyr Asn Trp Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110 


<210>  9
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Ile His Ser Leu Asn 
1               5       


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  10

Tyr Ile Ser Ser Asn Ser Thr Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Tyr Tyr Cys Thr Gly Gly Thr Cys Phe Phe Leu Pro Asp Leu 
1               5                   10                  15  


<210>  12
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Ala Ser Gln Asn Ile Ser Asn Phe Leu Ala 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Ala Ser Ile Arg Ala Thr 
1               5           


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Gln Arg Tyr Asn Trp Leu Thr 
1               5               


<210>  15
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala 
    130 


<210>  16
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110     


<210>  17
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Asp Ser Trp Ile His 
1               5       


<210>  18
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  18

Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  


<210>  19
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  23
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala 
    130         


<210>  24
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  25
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala 
    130             


<210>  26
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


<210>  27
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asp Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Lys Ala His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Phe His Phe Val Ser Gly Ser Pro Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala 
    130                 135 


<210>  28
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110 


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  29

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
1               5                   10              


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  30

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10          


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  31

Thr Val Ala Ala Pro 
1               5   


<210>  32
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  32
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt atccatagcc tgaattgggt ccgccaggct      120

ccagggaagg gactggagtg ggtttcgtat attagtagta acagtactac catatattac      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagga ctccctgtat      240

ctgcaaatga acagcctcag agacgaggac acggctgtat attactgtgc gagagactac      300

tactgtactg gtggtacctg cttctttctt cctgacctct ggggccgggg agccctggtc      360

accgtctcct cagcgagcac aaaaggacca tctgtatttc cactcgcccc cgaagtacag      420

ctcgtagagt ccggaggagg cctggtccaa cctggtggtt cccttcgact gtcatgtgcc      480

gcgtctggct tcactttttc cgattcatgg atacactggg tgaggcaagc acctggcaaa      540

ggtttggaat gggtggcctg gatctcaccg tatgggggta gtacttatta tgcggattca      600

gtaaagggaa gatttaccat ttcagcggac acaagtaaaa ataccgccta tttgcagatg      660

aacagcctgc gagcggaaga cactgctgtc tattattgtg ctagacgcca ctggcctggt      720

ggttttgact actgggggca gggcactttg gtgaccgttt cctca                      765


<210>  33
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile His 
            20                  25                  30          


Ser Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Asn Ser Thr Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Cys Thr Gly Gly Thr Cys Phe Phe Leu Pro Asp 
            100                 105                 110         


Leu Trp Gly Arg Gly Ala Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Glu Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val Arg Gln 
                165                 170                 175     


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro Tyr Gly 
            180                 185                 190         


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    210                 215                 220                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp Pro Gly 
225                 230                 235                 240 


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255 


<210>  34
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  34
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gaatatcagc aacttcttag cctggtacca acacaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccatca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcagtctca ccatcagcag cctggagcct      240

gaagattttg cagtttattt ctgtcagcag cgttacaact ggctcacttt cggcggaggg      300

accaaggtag agatcaaacg aacagtagca gctccgtcag tttttatttt tcctccagat      360

attcagatga cccagtcccc gtcctctctc tccgctagtg taggtgatag agtgacaata      420

acatgccggg ccagccagga tgtatccacg gcggtcgcgt ggtaccagca gaaacctggg      480

aaagccccca aactgcttat ttatagcgcc agcttcttgt actcaggagt acctagcaga      540

tttagcggtt caggaagtgg gactgatttt acactcacta tatcttccct gcaaccggag      600

gattttgcaa catattattg tcaacaatat ctctaccatc ccgcgacatt cgggcagggc      660

acaaaagtag agatcaaacg a                                                681


<210>  35
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  35

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Ser Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Tyr Asn Trp Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Asp Ile Gln Met Thr Gln Ser Pro Ser 
        115                 120                 125             


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
    130                 135                 140                 


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
145                 150                 155                 160 


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
                165                 170                 175     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            180                 185                 190         


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
        195                 200                 205             


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
    210                 215                 220                 


Ile Lys Arg 
225         


<210>  36
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  36
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gaatatcagc aacttcttag cctggtacca acacaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccatca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcagtctca ccatcagcag cctggagcct      240

gaagattttg cagtttattt ctgtcagcag cgttacaact ggctcacttt cggcggaggg      300

accaaggtag agatcaaacg aacagtagca gctccggata ttcagatgac ccagtccccg      360

tcctctctct ccgctagtgt aggtgataga gtgacaataa catgccgggc cagccaggat      420

gtatccacgg cggtcgcgtg gtaccagcag aaacctggga aagcccccaa actgcttatt      480

tatagcgcca gcttcttgta ctcaggagta cctagcagat ttagcggttc aggaagtggg      540

actgatttta cactcactat atcttccctg caaccggagg attttgcaac atattattgt      600

caacaatatc tctaccatcc cgcgacattc gggcagggca caaaagtaga gatcaaacga      660


<210>  37
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  37

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Ser Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Tyr Asn Trp Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
        115                 120                 125             


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
    130                 135                 140                 


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
145                 150                 155                 160 


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
                165                 170                 175     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
            180                 185                 190         


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
        195                 200                 205             


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
    210                 215                 220 


<210>  38
<211>  1243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  38
gaagtacagc tcgtagagtc cggaggaggc ctggtccaac ctggtggttc ccttcgactg       60

tcatgtgccg cgtctggctt cactttttcc gattcatgga tacactgggt gaggcaagca      120

cctggcaaag gtttggaatg ggtggcctgg atctcaccgt atgggggtag tacttattat      180

gcggattcag taaagggaag atttaccatt tcagcggaca caagtaaaaa taccgcctat      240

ttgcagatga acagcctgcg agcggaagac actgctgtct attattgtgc tagacgccac      300

tggcctggtg gttttgacta ctgggggcag ggcactttgg tgaccgtttc ctcagccgcg      360

agcacaaaag gaccatctgt atttccactc gcccccgagg tgcagctggt ggagtctggg      420

ggaggcttgg tacagcctgg ggggtccctg agaagtacag ctcgtagagt ccggaggagg      480

cctggtccaa cctggtggtt cccttcgact gtcatgtgcc gcgtctggct tcactttttc      540

cgattcatgg atacactggg tgaggcaagc acctggcaaa ggtttggaat gggtggcctg      600

gatctcaccg tatgggggta gtacttatta tgcggattca gtaaagggaa gatttaccat      660

ttcagcggac acaagtaaaa ataccgccta tttgcagatg aacagcctgc gagcggaaga      720

cactgctgtc tattattgtg ctagacgcca ctggcctggt ggttttgact actgggggca      780

gggcactttg gtgaccgttt cctcagccgc gagcacaaaa ggaccatctg tatttccact      840

cgcccccgag gtgcagctgg tggagtctgg gggaggcttg gtacagcctg gggggtccct      900

gagactctcc tgtgcagcct ctggattcac cttcagtatc catagcctga attgggtccg      960

ccaggctcca gggaagggac tggagtgggt ttcgtatatt agtagtaaca gtactaccat     1020

atattacgca gactctgtga agggccgatt caccatctcc agagacaatg ccaaggactc     1080

cctgtatctg caaatgaaca gcctcagaga cgaggacacg gctgtatatt actgtgcgag     1140

agactactac tgtactggtg gtacctgctt ctttcttcct gacctctggg gccggggagc     1200

cctggtcacc gtctcctcag cctccaccaa gggcccatcg gtc                       1243


<210>  39
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Ile His Ser Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Asn Ser Thr Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asp Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Cys Thr Gly Gly Thr Cys Phe 
225                 230                 235                 240 


Phe Leu Pro Asp Leu Trp Gly Arg Gly Ala Leu Val Thr Val Ser Ser 
                245                 250                 255     


Ala Ser Thr Lys Gly Pro Ser Val 
            260                 


<210>  40
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  40
gatattcaga tgacccagtc cccgtcctct ctctccgcta gtgtaggtga tagagtgaca       60

ataacatgcc gggccagcca ggatgtatcc acggcggtcg cgtggtacca gcagaaacct      120

gggaaagccc ccaaactgct tatttatagc gccagcttct tgtactcagg agtacctagc      180

agatttagcg gttcaggaag tgggactgat tttacactca ctatatcttc cctgcaaccg      240

gaggattttg caacatatta ttgtcaacaa tatctctacc atcccgcgac attcgggcag      300

ggcacaaaag tagagatcaa acgaaccgtc gccgcaccat cagtttttat ttttcctcca      360

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      420

ctctcctgca gggccagtca gaatatcagc aacttcttag cctggtacca acacaaacct      480

ggccaggctc ccaggctcct catctatgat gcatccatca gggccactgg catcccagcc      540

aggttcagtg gcagtgggtc tgggacagac ttcagtctca ccatcagcag cctggagcct      600

gaagattttg cagtttattt ctgtcagcag cgttacaact ggctcacttt cggcggaggg      660

accaaggtag agatcaaacg a                                                681


<210>  41
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Glu Ile Val Leu Thr Gln Ser Pro 
        115                 120                 125             


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
    130                 135                 140                 


Ala Ser Gln Asn Ile Ser Asn Phe Leu Ala Trp Tyr Gln His Lys Pro 
145                 150                 155                 160 


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Ile Arg Ala Thr 
                165                 170                 175     


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
            180                 185                 190         


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys 
        195                 200                 205             


Gln Gln Arg Tyr Asn Trp Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
    210                 215                 220                 


Ile Lys Arg 
225         


<210>  42
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  42
gatattcaga tgacccagtc cccgtcctct ctctccgcta gtgtaggtga tagagtgaca       60

ataacatgcc gggccagcca ggatgtatcc acggcggtcg cgtggtacca gcagaaacct      120

gggaaagccc ccaaactgct tatttatagc gccagcttct tgtactcagg agtacctagc      180

agatttagcg gttcaggaag tgggactgat tttacactca ctatatcttc cctgcaaccg      240

gaggattttg caacatatta ttgtcaacaa tatctctacc atcccgcgac attcgggcag      300

ggcacaaaag tagagatcaa acgaacagta gcagctccgg aaattgtgtt gacacagtct      360

ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag ggccagtcag      420

aatatcagca acttcttagc ctggtaccaa cacaaacctg gccaggctcc caggctcctc      480

atctatgatg catccatcag ggccactggc atcccagcca ggttcagtgg cagtgggtct      540

gggacagact tcagtctcac catcagcagc ctggagcctg aagattttgc agtttatttc      600

tgtcagcagc gttacaactg gctcactttc ggcggaggga ccaaggtaga gatcaaa         657


<210>  43
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
        115                 120                 125             


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Ser Asn 
    130                 135                 140                 


Phe Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 
145                 150                 155                 160 


Ile Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
                165                 170                 175     


Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu 
            180                 185                 190         


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Tyr Asn Trp Leu 
        195                 200                 205             


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
    210                 215                 


<210>  44
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asp Pro Asn Asn Asp Gly Thr Lys Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Thr Tyr Tyr Asp Ala Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  45
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  45

Asp Ile Trp Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Asn Ile Gln Thr Glu Asp Leu Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Ile Phe Ser Ser Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210>  46
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala 
    130         


<210>  47
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  48
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  48

Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Ala Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  49
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


<210>  50
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Met Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala 
    130             


<210>  51
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser His Ile Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  52
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu 
    130 


<210>  53
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  53

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


