
                                SEQUENCE LISTING

<110> TOLLNINE, INC.

<120> IMMUNOMODULATING POLYNUCLEOTIDE CONJUGATES AND METHODS OF USE

<130> 18649-20003.40

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> US 62/747,611
<151> 2018-10-18

<150> US 62/747,070
<151> 2018-10-17

<160> 586

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<400> 1
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 2
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by NH2-C6 as described in Table 2 of the specification 

<400> 2
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by NH2-C6-S-S-C6 as described in Table 2 of the specification

<400> 3
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 4
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<400> 4
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO-C6-S-S-C6 as described in Table 2 of the specification

<400> 5
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24)
<223> nucleoside-3'-phosphate

<400> 6
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 7
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO-C6-S-S-C6 as described in Table 2 of the specification

<400> 7
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<400> 8
tgctgctttt gtgcttttgt gctt                                        24

<210> 9
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO-C6-S-S-C6 as described in Table 2 of the specification

<400> 9
tgctgctttt gtgcttttgt gctt                                        24

<210> 10
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1, 23 
<223> nucleoside having a 3' tBuDS-Ph (ortho) triester

<400> 10
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 11
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1, 23
<223>  nucleoside having a 3' tBuDS-Ph (ortho) triester

<400> 11
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 12
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO-C6-S-S-C6 as described in Table 2 of the specification

<220> 
<221> misc_feature   
<222> 1, 23 
<223> nucleoside having a 3' tBuDS-Ph (ortho) triester

<400> 12
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 13
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO-C6-S-S-C6 as described in Table 2 of the specification

<220> 
<221> misc_feature   
<222> 1, 23
<223> nucleoside having a 3' tBuDS-Ph (ortho) triester

<400> 13
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 14
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<220> 
<221> misc_feature   
<222> 1, 23
<223> nucleoside having a 3' tBuDS-Ph (ortho) triester

<400> 14
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 15
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<220> 
<221> misc_feature   
<222> 1, 23
<223> nucleoside having a 3' tBuDS-Ph (ortho) triester

<400> 15
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<220> 
<221> misc_feature   
<222> 1, 19 
<223> nucleoside having a 3' tBuDS-Ph (ortho) triester

<400> 16
tccatgacgt tcctgacgtt                                             20

<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<220> 
<221> misc_feature   
<222> 1, 19
<223> nucleoside having a 3' tBuDS-Ph (ortho) triester

<400> 17
tccatgacgt tcctgacgtt                                             20

<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<400> 18
tccatgacgt tcctgacgtt                                             20

<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<400> 19
tccatgacgt tcctgacgtt                                             20

<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<400> 20
tccatgacgt tcctgacgtt                                             20

<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<400> 21
tccatgacgt tcctgacgtt                                             20

<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223>  nucleoside-3'-phosphorothioate

<400> 22
tccatgagct tcctgagctt                                             20

<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<400> 23
tccatgagct tcctgagctt                                             20

<210> 24
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> dT(DBCO)

<400> 24
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 25
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 9
<223> dT(DBCO)

<400> 25
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 26
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 12
<223> dT(DBCO)

<400> 26
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 27
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 17
<223> dT(DBCO)

<400> 27
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 28
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 24
<223> dT(DBCO)

<400> 28
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 29
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(26)
<223> nucleoside-3'-phosphorothioate

<400> 29
tcgcgacgtt cgcccgacgt tcggta                                      26

<210> 30
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(26)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<400> 30
tcgcgacgtt cgcccgacgt tcggta                                      26

<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<400> 31
tccatgacgt tcctgatgct                                             20

<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<400> 32
tccatgacgt tcctgatgct                                             20

<210> 33
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(23) 
<223> nucleoside-3'-phosphorothioate

<400> 33
tcgacgttcg tcgttcgtcg ttc                                         23

<210> 34
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(23) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<400> 34
tcgacgttcg tcgttcgtcg ttc                                         23

<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1, 23
<223> nucleoside having a 3' n-butyl triester

<400> 35
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 36
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<220> 
<221> misc_feature   
<222> 1, 23 
<223> nucleoside having a 3' n-butyl triester

<400> 36
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1, 19 
<223> nucleoside having a 3' n-butyl triester

<400> 37
tccatgacgt tcctgacgtt                                             20

<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<220> 
<221> misc_feature   
<222> 1, 19 
<223> nucleoside having a 3' n-butyl triester

<400> 38
tccatgacgt tcctgacgtt                                             20

<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1, 20 
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 39
tccatgacgt tcctgacgtt                                             20

<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1, 19 
<223> nucleoside having a 3' n-butyl triester

<400> 40
tccatgacgt tcctgacgtt                                             20

<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1, 20 
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 41
tccatgacgt tcctgacgtt                                             20

<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 42
tccatgacgt tcctgacgtt                                             20

<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 43
tccatgacgt tcctgacgtt                                             20

<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 44
tccatgacgt tcctgacgtt                                             20

<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 45
tccatgacgt tcctgacgtt                                             20

<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' homopropargyl triester (hPro)

<400> 46
tccatgacgt tcctgacgtt                                             20

<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 5
<223> nucleoside having a 3' homopropargyl triester (hPro)

<400> 47
tccatgacgt tcctgacgtt                                             20

<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 10
<223> nucleoside having a 3' homopropargyl triester (hPro)

<400> 48
tccatgacgt tcctgacgtt                                             20

<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 11
<223> nucleoside having a 3' homopropargyl triester (hPro)

<400> 49
tccatgacgt tcctgacgtt                                             20

<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 14
<223> nucleoside having a 3' homopropargyl triester (hPro)

<400> 50
tccatgacgt tcctgacgtt                                             20

<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' homopropargyl triester (hPro)

<400> 51
tccatgacgt tcctgacgtt                                             20

<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' homopropargyl triester (hPro)

<400> 52
tccatgacgt tcctgacgtt                                             20

<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(2)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (3)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (15)..(20)
<223> nucleoside-3'-phosphate

<400> 53
gggggacgat cgtcgggggg                                             20

<210> 54
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(25)
<223> nucleoside-3'-phosphorothioate

<400> 54
tcgtcgtcgt tcgaacgacg ttgat                                       25

<210> 55
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(22)
<223> nucleoside-3'-phosphorothioate

<400> 55
tcgtcgtttt cggcgcgcgc cg                                          22

<210> 56
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(29)
<223> nucleoside-3'-phosphorothioate

<400> 56
tcgcgaacgt tcgccgcgtt cgaacgcgg                                   29

<210> 57
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(23)
<223> nucleoside-3'-phosphorothioate

<400> 57
tcgtcgacga tcggcgcgcg ccg                                         23

<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 58
tccatgacgt tcctgacgtt                                             20

<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 59
tccatgacgt tcctgacgtt                                             20

<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 10
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 60
tccatgacgt tcctgacgtt                                             20

<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 11
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 61
tccatgacgt tcctgacgtt                                             20

<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 14
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 62
tccatgacgt tcctgacgtt                                             20

<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 63
tccatgacgt tcctgacgtt                                             20

<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 64
tccatgacgt tcctgacgtt                                             20

<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 65
tccatgacgt tcctgacgtt                                             20

<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 66
tccatgacgt tcctgacgtt                                             20

<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 10
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 67
tccatgacgt tcctgacgtt                                             20

<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 11
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)


<400> 68
tccatgacgt tcctgacgtt                                             20

<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 14
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)


<400> 69
tccatgacgt tcctgacgtt                                             20

<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)


<400> 70
tccatgacgt tcctgacgtt                                             20

<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)


<400> 71
tccatgacgt tcctgacgtt                                             20

<210> 72
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)


<400> 72
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 73
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)


<400> 73
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)


<400> 74
tccatgacgt tcctgatgct                                             20

<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)


<400> 75
tccatgacgt tcctgatgct                                             20

<210> 76
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester


<400> 76
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 77
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 77
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 78
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 78
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 79
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 8
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 79
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 80
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 9
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 80
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 81
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 10
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 81
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 82
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 82
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 83
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 15
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 83
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 84
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 16
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 84
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 85
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 17
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 85
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 86
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 18
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 86
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 87
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 87
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 88
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 88
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 89
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (6)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 89
tccatgacgt tcctgacgtt                                             20

<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(10) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (11)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 90
tccatgacgt tcctgacgtt                                             20

<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(15) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (16)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester


<400> 91
tccatgacgt tcctgacgtt                                             20

<210> 92
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (6)..(20) 
<223> nucleoside-3'-phosphate

<400> 92
tccatgacgt tcctgacgtt                                             20

<210> 93
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(10) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (11)..(20) 
<223> nucleoside-3'-phosphate


<400> 93
tccatgacgt tcctgacgtt                                             20

<210> 94
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(15) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (16)..(20) 
<223> nucleoside-3'-phosphate

<400> 94
tccatgacgt tcctgacgtt                                             20

<210> 95
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 95
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 96
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 3
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 96
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 97
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 97
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 98
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 6
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 98
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 99
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 11
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 99
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 100
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 100
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 101
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 14
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 101
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 102
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 102
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 103
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 21
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 103
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 104
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 22
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 104
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 105
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 105
tccatgacgt tcctgacgtt                                             20

<210> 106
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 106
tccatgacgt tcctgacgtt                                             20

<210> 107
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 3
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 107
tccatgacgt tcctgacgtt                                             20

<210> 108
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 108
tccatgacgt tcctgacgtt                                             20

<210> 109
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 109
tccatgacgt tcctgacgtt                                             20

<210> 110
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 6
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 110
tccatgacgt tcctgacgtt                                             20

<210> 111
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 111
tccatgacgt tcctgacgtt                                             20

<210> 112
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 8
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 112
tccatgacgt tcctgacgtt                                             20

<210> 113
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 9
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 113
tccatgacgt tcctgacgtt                                             20

<210> 114
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 10
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 114
tccatgacgt tcctgacgtt                                             20

<210> 115
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 11
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 115
tccatgacgt tcctgacgtt                                             20

<210> 116
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 116
tccatgacgt tcctgacgtt                                             20

<210> 117
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 117
tccatgacgt tcctgacgtt                                             20

<210> 118
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 14
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19 
<223> nucleoside having a 3' n-butyl triester

<400> 118
tccatgacgt tcctgacgtt                                             20

<210> 119
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 15
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 119
tccatgacgt tcctgacgtt                                             20

<210> 120
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 16
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 120
tccatgacgt tcctgacgtt                                             20

<210> 121
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 17
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 121
tccatgacgt tcctgacgtt                                             20

<210> 122
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 18
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' n-butyl triester

<400> 122
tccatgacgt tcctgacgtt                                             20

<210> 123
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> modified by IR700 dye

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 123
tccatgacgt tcctgacgtt                                             20

<210> 124
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by IR700 dye

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 124
tccatgacgt tcctgacgtt                                             20

<210> 125
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphorothioate

<400> 125
tcgtcgtttc gtcgttttgt cgtt                                        24

<210> 126
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<400> 126
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 127
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by DBCO

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl

<400> 127
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 128
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 128
tgctgctttt gtgcttttgt gctt                                        24

<210> 129
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (7)..(27) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (28)..(30) 
<223> nucleoside-3'-phosphorothioate

<400> 129
tcattggaaa acgttcttcg gggcgttctt                                  30

<210> 130
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (7)..(27) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (28)..(30) 
<223> nucleoside-3'-phosphorothioate

<400> 130
tcattggaaa agcttcttgc ggggcttctt                                  30

<210> 131
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(30) 
<223> nucleoside-3'-phosphate

<400> 131
tcattggaaa acgttcttcg gggcgttctt                                  30

<210> 132
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(30) 
<223> nucleoside-3'-phosphate

<400> 132
aagaacgccc cgaagaacgt tttccaatga                                  30

<210> 133
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(30) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 29
<223> nucleoside having a 3' n-butyl triester

<400> 133
tcattggaaa acgttcttcg gggcgttctt                                  30

<210> 134
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(30) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 29
<223> nucleoside having a 3' n-butyl triester

<400> 134
aagaacgccc cgaagaacgt tttccaatga                                  30

<210> 135
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(30) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1, 29 
<223> nucleoside having a 3' n-butyl triester

<400> 135
tcattggaaa acgttcttcg gggcgttctt                                  30

<210> 136
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(30) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1, 29 
<223> nucleoside having a 3' n-butyl triester

<400> 136
aagaacgccc cgaagaacgt tttccaatga                                  30

<210> 137
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(30) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' n-butyl triester

<400> 137
tcattggaaa acgttcttcg gggcgttctt                                  30

<210> 138
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(30) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' n-butyl triester

<400> 138
aagaacgccc cgaagaacgt tttccaatga                                  30

<210> 139
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (6)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (17)..(20) 
<223> nucleoside-3'-phosphorothioate

<400> 139
tccatgacgt tcctgacgtt                                             20

<210> 140
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (17)..(20) 
<223> nucleoside-3'-phosphorothioate

<400> 140
tccatgacgt tcctgacgtt                                             20

<210> 141
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (6)..(18) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (19)..(20) 
<223> nucleoside-3'-phosphorothioate

<400> 141
tccatgacgt tcctgacgtt                                             20

<210> 142
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (6)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' tBuDS-Ph (ortho) triester

<400> 142
tccatgacgt tcctgacgtt                                             20

<210> 143
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (6)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 19
<223> nucleoside having a 3' tBuDS-Ph (ortho) triester

<400> 143
tccatgacgt tcctgacgtt                                             20

<210> 144
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<400> 144
aacgacaaaa cgacaaaacg acga                                        24

<210> 145
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 145
aacgacaaaa cgacaaaacg acga                                        24

<210> 146
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(22) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 146
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 147
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(18) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (19)..(23) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 147
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 148
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(22) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 17
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 148
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 149
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(18) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (19)..(23) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 17
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 149
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 150
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (6)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 150
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 151
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(23) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside-3'-phosphate

<400> 151
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 152
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (6)..(22) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside-3'-phosphate

<400> 152
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 153
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (6)..(22) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> (23)..(24) 
<223> nucleoside-3'-phosphorothioate

<400> 153
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 154
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (6)..(23) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside-3'-phosphorothioate

<400> 154
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 155
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(25) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside having a 3' n-butyl triester

<400> 155
ttcgtcgttt tgtcgttttg tcgtt                                       25

<210> 156
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(26) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 6
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 25
<223> nucleoside having a 3' n-butyl triester

<400> 156
tttcgtcgtt ttgtcgtttt gtcgtt                                      26

<210> 157
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(27) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 26
<223> nucleoside having a 3' n-butyl triester

<400> 157
gtttcgtcgt tttgtcgttt tgtcgtt                                     27

<210> 158
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(27) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 3
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 26
<223> nucleoside having a 3' n-butyl triester

<400> 158
gtttcgtcgt tttgtcgttt tgtcgtt                                     27

<210> 159
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(27) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 26
<223> nucleoside having a 3' n-butyl triester

<400> 159
gtttcgtcgt tttgtcgttt tgtcgtt                                     27

<210> 160
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(27) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 3
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 26
<223> nucleoside having a 3' n-butyl triester

<400> 160
gtttcgtcgt tttgtcgttt tgtcgtt                                     27

<210> 161
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 161
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 162
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(18) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 17
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 162
tcgtcgtttt gtcgtttt                                               18

<210> 163
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(22) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> (23)..(24) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 163
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 164
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 164
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 165
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 165
tcgucgtttt gtcgttttgt cgtt                                        24

<210> 166
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<220> 
<221> misc_feature   
<222> 4
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 166
tcgucgtttt gtcgttttgt cgtt                                        24

<210> 167
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 167
ucgucgtttt gtcgttttgt cgtt                                        24

<210> 168
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by C3 spacer (-(CH2)3-OH) (5' phosphate)

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine 

<220> 
<221> misc_feature   
<222> 4
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 168
ucgucgtttt gtcgttttgt cgtt                                        24

<210> 169
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 169
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 170
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> modified by C3 spacer (-(CH2)3-OH) (5' phosphate)

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 170
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 171
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(18) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 171
tcgtcgtttt gtcgtttt                                               18

<210> 172
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 172
tcgtcgtttt gtcgtt                                                 16

<210> 173
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 173
tcgtcgtttt gtcg                                                   14

<210> 174
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(12) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 174
tcgtcgtttt gt                                                     12

<210> 175
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(18) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 175
ucgtcgtttt gtcgtttt                                               18

<210> 176
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(17) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 176
utcgtcgttt tgtcgtt                                                17

<210> 177
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 177
ucgtcgtttt gtcg                                                   14

<210> 178
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(12) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 178
ucgtcgtttt gt                                                     12

<210> 179
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 179
ucgucgtttt gtcgttttgt cgtt                                        24

<210> 180
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 180
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 181
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 181
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 182
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 182
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 183
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 183
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 184
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 184
tccatgacgt tcctgatgct                                             20

<210> 185
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 185
tccatgacgt tcctgatgct                                             20

<210> 186
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 186
tccatgacgt tcctgatgct                                             20

<210> 187
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(15) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 15
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 187
ucgtcgtttg tcgtt                                                  15

<210> 188
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 188
ucgtcgttgt cgtt                                                   14

<210> 189
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 189
ucgtcgtgtc gtt                                                    13

<210> 190
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(12) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 12
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 190
ucgtcgttcg tt                                                     12

<210> 191
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(11) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 11
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 191
ucgtcgtcgt t                                                      11

<210> 192
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' n-butyl triester

<400> 192
ugctgctttt gtgcttttgt gctt                                        24

<210> 193
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 193
tccatgacgt tcctgacgtt                                             20

<210> 194
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 20
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 194
tccatgacgt tcctgacgtt                                             20

<210> 195
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 195
tccatgacgt tcctgacgtt                                             20

<210> 196
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(20) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 20
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 196
tccatgacgt tcctgacgtt                                             20

<210> 197
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(25) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> (2)..(25) 
<223> 2'-fluoronucleotide

<400> 197
taacgacaaa acgacaaaac gacga                                       25

<210> 198
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(25) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (1)..(24) 
<223> 2'-fluoronucleotide

<220> 
<221> misc_feature   
<222> 25
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 25
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 198
aacgacaaaa cgacaaaacg acgat                                       25

<210> 199
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> (7)..(12) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (13)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 199
ucgtcgtttt gtcgtt                                                 16

<210> 200
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> (7)..(12) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (13)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)


<400> 200
ucgtcgtttt gtcgtt                                                 16

<210> 201
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> (7)..(8) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (9)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 201
ucgtcgtttt gtcgtt                                                 16

<210> 202
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(8) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> (9)..(10) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (11)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)


<400> 202
ucgtcgtttt gtcgtt                                                 16

<210> 203
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(10) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> (11)..(12) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (13)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 203
ucgtcgtttt gtcgtt                                                 16

<210> 204
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 6
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 204
ucgtcgtttt gtcgtt                                                 16

<210> 205
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 205
ucgtcgtttt gtcgtt                                                 16

<210> 206
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 9
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 206
ucgtcgtttt gtcgtt                                                 16

<210> 207
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 11
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 207
ucgtcgtttt gtcgtt                                                 16

<210> 208
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 14
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 208
ucgtcgtttt gtcgtt                                                 16

<210> 209
<211> 8
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(8) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 8
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 209
ucgtcgtt                                                          8

<210> 210
<211> 8
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(8) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 8
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 8
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 210
ucgtcgtt                                                          8

<210> 211
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 6
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 211
ucgttt                                                            6

<210> 212
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 6
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 212
ucgttt                                                            6

<210> 213
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 213
ucgtcgtgtc gtt                                                    13

<210> 214
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)


<400> 214
ucgtcgtgtt ttt                                                    13

<210> 215
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)


<400> 215
ucgttttgtc gtt                                                    13

<210> 216
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(12) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 12
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)


<400> 216
ucgtttgtcg tt                                                     12

<210> 217
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(11) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 11
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 11
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)


<400> 217
ucgttgtcgt t                                                      11

<210> 218
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(10) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 10
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 10
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 218
ucgtgtcgtt                                                        10

<210> 219
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 219
ugctgctttt gtgctt                                                 16

<210> 220
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 15
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 220
ucgtcgtttt gtcgtt                                                 16

<210> 221
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(16) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 15
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 221
ucgtcgtttt gtcgtt                                                 16

<210> 222
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 222
gggacgatcg tct                                                    13

<210> 223
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1, 2, 14, 15 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (3)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 223
gggacgatcg tctgg                                                  15

<210> 224
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1, 2, 14, 15 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (3)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 8
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 224
gggacgatcg tctgg                                                  15

<210> 225
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 6
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 225
ucgtcgtgtc gtt                                                    13

<210> 226
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 7
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 226
ucgtcgtgtc gtt                                                    13

<210> 227
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 9
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 227
ucgtcgtgtc gtt                                                    13

<210> 228
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 12
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 228
ucgtcgtgtc gtt                                                    13

<210> 229
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 3
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 229
ucgtcgtgtc gtt                                                    13

<210> 230
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 11
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature   
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)


<400> 230
ucgtcgtgtc gtt                                                    13

<210> 231
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (6)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> (10)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 231
ucgtcgtgtc gtt                                                    13

<210> 232
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(23) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 232
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 233
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(23) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 23
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 24
<223> nucleoside-3'-phosphate 

<220> 
<221> misc_feature   
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 233
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 234
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 234
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 235
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(15) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 15
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 16
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 235
tcgtcgtttt gtcgtt                                                 16

<210> 236
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(15) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 15
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 16
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 236
ucgtcgtttt gtcgtt                                                 16

<210> 237
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(12) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3' phosphate)

<400> 237
tcgtcgtgtc gtt                                                    13

<210> 238
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(12)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 238
ucgtcgtgtc gtt                                                    13

<210> 239
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1, 2, 5, 10, 12, 13
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 3, 4, 6, 7, 8, 9, 11
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 239
ucgtcgtgtc gtt                                                    13

<210> 240
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1, 2, 5, 10
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 3, 4, 6, 7, 8, 9, 11, 12, 13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 240
ucgtcgtgtc gtt                                                    13

<210> 241
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(2)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> (3)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 241
ucgtcgtgtc gtt                                                    13

<210> 242
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> (2)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 242
ucgtcgtgtc gtt                                                    13

<210> 243
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 243
ucgtcgtgtc gtt                                                    13

<210> 244
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(2)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> (3)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 244
ucgtcgtgtc gtt                                                    13

<210> 245
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> (2)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 245
ucgtcgtgtc gtt                                                    13

<210> 246
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 246
ucgtcgtgtc gtt                                                    13

<210> 247
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(2)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> (3)..(24)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 247
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 248
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> (2)..(24)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 248
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 249
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(24)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 24
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 249
ucgtcgtttt gtcgttttgt cgtt                                        24

<210> 250
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1, 2, 3, 4, 5, 10, 11, 12, 13
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 6, 7, 8, 9
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 250
ucgtcgtgtc gtt                                                    13

<210> 251
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1, 2, 3, 4, 5, 10
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 6, 7, 8, 9, 11, 12, 13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 251
ucgtcgtgtc gtt                                                    13

<210> 252
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1, 2, 4, 5, 10
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 3, 6, 7, 8, 9, 11, 12, 13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 252
ucgtcgtgtc gtt                                                    13

<210> 253
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(5)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> (6)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> (10)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 253
ucgtcgtgtc gtt                                                    13

<210> 254
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(5)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> (6)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> (10)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 11
<223> contains a 2'-OMe-modified ribose

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 254
ucgtcgtgtc gtt                                                    13

<210> 255
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(5)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> (6)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> (10)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 12
<223> contains a 2'-OMe-modified ribose

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 255
ucgtcgtgtc gtt                                                    13

<210> 256
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(5)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> (6)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> (10)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 13
<223> contains a 2'-OMe-modified ribose

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 256
ucgtcgtgtc gtt                                                    13

<210> 257
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(5)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> (6)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> (10)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 12, 13
<223> contains a 2'-OMe-modified ribose

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 257
ucgtcgtgtc gtt                                                    13

<210> 258
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(5)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> (6)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> (10)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> (11)..(13)
<223> each contains a 2'-OMe-modified ribose

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 258
ucgtcgtgtc gtt                                                    13

<210> 259
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(5)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> contains a 2'-OMe-modified ribose

<220> 
<221> misc_feature
<222> (6)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> (10)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 259
ucgtcgtgtc gtt                                                    13

<210> 260
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(5)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> (6)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> (10)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> contains a 2'-OMe-modified ribose

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 260
ucgtcgtgtc gtt                                                    13

<210> 261
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(5)
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> (6)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> (10)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> contains a 2'-OMe-modified ribose

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 261
ucgtcgtgtc gtt                                                    13

<210> 262
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1, 4
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> (2)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 262
ucgucgtgtc gtt                                                    13

<210> 263
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1, 9
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> (2)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 263
ucgtcgtguc gtt                                                    13

<210> 264
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> (2)..(14) 
<223> 2'-fluoronucleotide

<400> 264
taacgacacg acga                                                   14

<210> 265
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> 2'-fluoronucleotide

<220> 
<221> misc_feature
<222> 14
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<400> 265
aacgacacga cgat                                                   14

<210> 266
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1, 9
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 266
ucgtcgtguc gtt                                                    13

<210> 267
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(12) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 3
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 12
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 267
cgtcgtgtcg tt                                                     12

<210> 268
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(12) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 3
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 8
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 12
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 268
cgtcgtgucg tt                                                     12

<210> 269
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> (2)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 269
tcgtcgtgtc gtt                                                    13

<210> 270
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 270
tcgtcgtgtc gtt                                                    13

<210> 271
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> (2)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 271
ucgtcgtgtc gtt                                                    13

<210> 272
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 272
ucgtcgtgtc gtt                                                    13

<210> 273
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 273
ugctgctgtg ctt                                                    13

<210> 274
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 274
ucgagctgtc gtt                                                    13

<210> 275
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 275
ucgtcgtgac gtt                                                    13

<210> 276
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 276
ucgacgtgac gtt                                                    13

<210> 277
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 277
acgacgtgac gtt                                                    13

<210> 278
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 278
acgacgtgac gtt                                                    13

<210> 279
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 3
<223> 7-deaza-2'-deoxyguanosine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 279
ucgtcgtgtc gtt                                                    13

<210> 280
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 6
<223> 7-deaza-2'-deoxyguanosine

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 280
ucgtcgtgtc gtt                                                    13

<210> 281
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 11
<223> 7-deaza-2'-deoxyguanosine

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 281
ucgtcgtgtc gtt                                                    13

<210> 282
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 3, 6, 11
<223> 7-deaza-2'-deoxyguanosine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' tBuDS-Ph (ortho) triester (PS)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 282
ucgtcgtgtc gtt                                                    13

<210> 283
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 3, 6, 11
<223> 7-deaza-2'-deoxyguanosine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 283
acgacgtgac gtt                                                    13

<210> 284
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 3, 6, 11
<223> 7-deaza-2'-deoxyguanosine

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 284
acgacgtgac gtt                                                    13

<210> 285
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(12)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 13
<223> modified by OH

<400> 285
ucgtcgtgtc gtt                                                    13

<210> 286
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 286
ucgtcgtgtc gtt                                                    13

<210> 287
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(12)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside-3'-phosphate

<400> 287
ucgtcgtgtc gtt                                                    13

<210> 288
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 288
ucgtcgtgtc gtt                                                    13

<210> 289
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(12) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside-3'-phosphate

<400> 289
ucgtcgtgtc gtt                                                    13

<210> 290
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 290
tcgtcgtgtc gtt                                                    13

<210> 291
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(12)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside-3'-phosphate

<400> 291
tcgtcgtgtc gtt                                                    13

<210> 292
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 13
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature   
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 292
ucgtcgtgac gtt                                                    13


<210> 293
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 13
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 293
ucgacgtgac gtt                                                    13

<210> 294
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(19)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 7
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 19
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 19
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 294
tccatgucgt tccttgatt                                              19

<210> 295
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(16)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 7
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 16
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 295
tccatgucgt tccttt                                                 16

<210> 296
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 7
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 296
tccatgucgt tctt                                                   14

<210> 297
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(11)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 7
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 11
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 11
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 297
tccatgucgt t                                                      11

<210> 298
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 298
tucgtcgtgt cgtt                                                   14

<210> 299
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1, 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 299
uucgtcgtgt cgtt                                                   14

<210> 300
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 300
uucgtcgtgt cgtt                                                   14

<210> 301
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 301
tcgucgtgtc gtt                                                    13

<210> 302
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(3)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> (5)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 302
tcgucgtgtc gtt                                                    13

<210> 303
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(3)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> (5)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 7
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 303
tcgucgtgtc gtt                                                    13

<210> 304
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 304
ucgtcgtgac gtt                                                    13

<210> 305
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 305
ucgacgtgac gtt                                                    13

<210> 306
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 1
<223> modified by C3 spacer (-(CH2)3-OH) ( 5'-phosphate)

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 306
ucgtcgtgtc gtt                                                    13

<210> 307
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-fluoro-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 307
ucgtcgtgtc gtt                                                    13

<210> 308
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 308
ucgtcgtgtc gtt                                                    13

<210> 309
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 1
<223> modified by C3 spacer (-(CH2)3-OH) (5'-phosphorothioate)

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 309
ucgtcgtgtc gtt                                                    13

<210> 310
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 310
ucgtcgtgtc gtt                                                    13

<210> 311
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 311
ucgtcgtgtc gtt                                                    13

<210> 312
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 312
tcgucgtgtc gtt                                                    13

<210> 313
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 313
tucgtcgtga cgtt                                                   14

<210> 314
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 314
uucgtcgtga cgtt                                                   14

<210> 315
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 1
<223> modified by 6-aminohex-1-yl

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 315
ucgtcgtgac gtt                                                    13

<210> 316
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 316
uucgtcgtga cgtt                                                   14

<210> 317
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 9
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 317
tcgacgtguc gtt                                                    13

<210> 318
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 318
tcgacgtgac gtt                                                    13

<210> 319
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1, 9
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 319
ucgacgtguc gtt                                                    13

<210> 320
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 320
ucgtccatga cgtt                                                   14

<210> 321
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1, 10
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 321
ucgtccatgu cgtt                                                   14

<210> 322
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 10
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 322
tcgtccatgu cgtt                                                   14

<210> 323
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 323
ucgtcgtgac gtt                                                    13

<210> 324
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 5
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 324
catgucgttc cttt                                                   14

<210> 325
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(12)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 3
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 12
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 325
tgucgttcct tt                                                     12

<210> 326
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 5
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 326
tatgucgttc cttt                                                   14

<210> 327
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(16)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 16
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 16
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 327
tccatgacgt tccttt                                                 16

<210> 328
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 328
ugctgctgag ctt                                                    13

<210> 329
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 329
ugcagctgag ctt                                                    13

<210> 330
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> (2)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-trifluoromethyl-thymidine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 330
tcgtcgtgtc gtt                                                    13

<210> 331
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-trifluoromethyl-thymidine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 331
tcgtcgtgtc gtt                                                    13

<210> 332
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> DBCO-C6-dT, where C6 = hexane-1,6-diyl

<220> 
<221> misc_feature
<222> 7, 13
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 332
ucgtcgtgtc gtt                                                    13

<210> 333
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> DBCO-C6-dT, where C6 = hexane-1,6-diyl

<220> 
<221> misc_feature
<222> 9, 13
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 333
ucgtcgtgtc gtt                                                    13

<210> 334
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> DBCO-C6-dT, where C6 = hexane-1,6-diyl

<220> 
<221> misc_feature
<222> 13
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 334
ucgtcgtgtc gtt                                                    13

<210> 335
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> DBCO-C6-dT, where C6 = hexane-1,6-diyl

<220> 
<221> misc_feature
<222> 9
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 335
ucgtcgtgtc gtt                                                    13

<210> 336
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> DBCO-C6-dT, where C6 = hexane-1,6-diyl

<220> 
<221> misc_feature
<222> 7
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 336
ucgtcgtgtc gtt                                                    13

<210> 337
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> DBCO-C6-dT, where C6 = hexane-1,6-diyl

<220> 
<221> misc_feature
<222> 12, 13
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 337
ucgtcgtgtc gtt                                                    13

<210> 338
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 5
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 338
tatgugcttc cttt                                                   14

<210> 339
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 7, 12
<223> PEG4 dT triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 339
ucgtcgtgtc gtt                                                    13

<210> 340
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 9, 13
<223> PEG4 dT triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 340
ucgtcgtgtc gtt                                                    13

<210> 341
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> PEG4 dT triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 341
ucgtcgtgtc gtt                                                    13

<210> 342
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 9
<223> PEG4 dT triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 342
ucgtcgtgtc gtt                                                    13

<210> 343
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 7
<223> PEG4 dT triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 343
ucgtcgtgtc gtt                                                    13

<210> 344
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 12, 13
<223> PEG4 dT triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 344
ucgtcgtgtc gtt                                                    13

<210> 345
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1, 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 345
tugctgctga gctt                                                   14

<210> 346
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 5
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 346
tugctgctga gctt                                                   14

<210> 347
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 347
tugctgctga gctt                                                   14

<210> 348
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 7, 12
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 348
ucgtcgtgtc gtt                                                    13

<210> 349
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 7, 9
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 349
ucgtcgtgtc gtt                                                    13

<210> 350
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 9, 12
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 350
ucgtcgtgtc gtt                                                    13

<210> 351
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 7
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 351
ucgtcgtgtc gtt                                                    13

<210> 352
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 352
ucgtcgtgtc gtt                                                    13

<210> 353
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 353
tucgtcgtga cgtt                                                   14

<210> 354
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 354
tugctgctga gctt                                                   14

<210> 355
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,8,9,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4, 12
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 355
ucgtcgtgtc gtt                                                    13

<210> 356
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 356
ucgtcgtgtc gtt                                                    13

<210> 357
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,8,9,10,11,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4, 12
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 357
ucgtcgtgtc gtt                                                    13

<210> 358
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(13)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 358
ucgtcgtgtc gtt                                                    13

<210> 359
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 359
ucgtcgtgtc gtt                                                    13

<210> 360
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,4,5,6,7,8,9,10,11,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 12
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' n-butyl triester

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' DBCO-NH-PEG2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 360
ucgtcgtgtc gtt                                                    13

<210> 361
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 361
ucgtcgtgtc gtt                                                    13

<210> 362
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,8,9,10,11,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 12
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 362
ucgtcgtgtc gtt                                                    13

<210> 363
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,8,9,10,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 11
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 11
<223> guanosine having a 3' ethyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 363
ucgtcgtgtc gtt                                                    13

<210> 364
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,8,9,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 10
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 10
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 364
ucgtcgtgtc gtt                                                    13

<210> 365
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,8,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 9
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 9
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 365
ucgtcgtgtc gtt                                                    13

<210> 366
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 8
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 8
<223> guanosine having a 3' ethyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 366
ucgtcgtgtc gtt                                                    13

<210> 367
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 7
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 7
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 367
ucgtcgtgtc gtt                                                    13

<210> 368
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,7,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 6
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 6
<223> guanosine having a 3' ethyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 368
ucgtcgtgtc gtt                                                    13

<210> 369
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,6,7,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 5
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 5
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 369
ucgtcgtgtc gtt                                                    13

<210> 370
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,5,6,7,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 3, 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 3
<223> guanosine having a 3' ethyl triester

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 370
ucgtcgtgtc gtt                                                    13

<210> 371
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,3,5,6,7,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 2
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 371
ucgtcgtgtc gtt                                                    13

<210> 372
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1,2,3,5,6,7,8,9,10,11,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 12
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature
<222> 4
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature
<222> 12
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature
<222> 13
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 372
ucgtcgtgtc gtt                                                    13

<210> 373
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> modified by X5-C3 as described in Table 2 of the specification

<400> 373
tucgtcgtga cgtt                                                   14

<210> 374
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 13,14
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 374
tucgtcgtga cgtt                                                   14

<210> 375
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 12, 13
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 375
tucgtcgtga cgtt                                                   14

<210> 376
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 11, 12
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 376
tucgtcgtga cgtt                                                   14

<210> 377
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 10, 11
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 377
tucgtcgtga cgtt                                                   14

<210> 378
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 9, 10
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 378
tucgtcgtga cgtt                                                   14

<210> 379
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 8, 9
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 379
tucgtcgtga cgtt                                                   14

<210> 380
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 7, 8
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 380
tucgtcgtga cgtt                                                   14

<210> 381
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 6, 7
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 381
tucgtcgtga cgtt                                                   14

<210> 382
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 5, 6
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 382
tucgtcgtga cgtt                                                   14

<210> 383
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 4, 5
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 383
tucgtcgtga cgtt                                                   14

<210> 384
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 3, 4
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 384
tucgtcgtga cgtt                                                   14

<210> 385
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 2, 3
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 385
tucgtcgtga cgtt                                                   14

<210> 386
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1, 2
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 386
tucgtcgtga cgtt                                                   14

<210> 387
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> (1)..(14)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature
<222> 1
<223> modified by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature
<222> 2
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature
<222> 14
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 387
tucgtcgtga cgtt                                                   14

<210> 388
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4,5 
<223> linked by X5-DBCO as described in Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 388
tucgcgtgac gtt                                                    13

<210> 389
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4,5 
<223> linked by X5-DBCO as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 389
tucgcgtgac gtt                                                    13

<210> 390
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodouridine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 2,3 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> (5)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 390
ucgtcgtgtc gtt                                                    13

<210> 391
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodouridine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 391
ucgtcgtgtc gtt                                                    13

<210> 392
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(4) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodouridine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 3 
<223> guanosine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> (5)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 392
ucgtcgtgtc gtt                                                    13

<210> 393
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4,10,11,12,13
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 10 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 11 
<223> guanosine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 12,13 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 393
ucgtcgtgtc gtt                                                    13

<210> 394
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,4,10,11,12,13 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> (5)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodouridine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 2,10 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 3,11 
<223> guanosine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 12,13 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 394
ucgtcgtgtc gtt                                                    13

<210> 395
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodouridine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 2,5,10 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 3,6,8,11 
<223> guanosine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 7,9,12,13 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13  
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 395
ucgtcgtgtc gtt                                                    13

<210> 396
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,6,7,8,9,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2,4,5,10 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2,5,10 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 396
ucgtcgtgtc gtt                                                    13

<210> 397
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,7,9,10,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4,6,8,11 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 6,8,11 
<223> guanosine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 397
ucgtcgtgtc gtt                                                    13

<210> 398
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,8,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4,7,9,12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 7,9,12 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 398
ucgtcgtgtc gtt                                                    13

<210> 399
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,8,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2,4,7,9,12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 7,9,12 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 399
ucgtcgtgtc gtt                                                    13

<210> 400
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,8,10,11,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4, 7, 9, 12
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 7, 9
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 12 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 400
ucgtcgtgtc gtt                                                    13

<210> 401
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 11, 13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4, 7, 9
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 12 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 401
ucgtcgtgtc gtt                                                    13

<210> 402
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,10,12,13  
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 11 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 11 
<223> guanosine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 402
ucgtcgtgtc gtt                                                    13

<210> 403
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 10 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2, 10 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 403
ucgtcgtgtc gtt                                                    13

<210> 404
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,10,11,12,14
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 13 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 404
ucgtcgttgt cgtt                                                   14

<210> 405
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,9,10,11,12,14
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 8, 13 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 8, 13 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 405
ucgtcgttgt cgtt                                                   14

<210> 406
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,8,9,10,11,12,14 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 7, 13 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 7, 13 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 406
ucgtcgttgt cgtt                                                   14

<210> 407
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 7,8 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 12  
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13  
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 407
ucgtcgtgtc gtt                                                    13

<210> 408
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 6,7 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 12 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 408
ucgtcgtgtc gtt                                                    13

<210> 409
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,9,10,11,12,14 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 8, 13 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 8, 13 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 409
ucgtcgttgt cgtt                                                   14

<210> 410
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 7,8
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 12 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 410
ucgtcgtgtc gtt                                                    13

<210> 411
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 1
<223> modified by X3 abasic spacer described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 411
ucgtcgtgtc gtt                                                    13

<210> 412
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 1,2 
<223> linked by X3 abasic spacer described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 412
ucgtcgtgtc gtt                                                    13

<210> 413
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2,3 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 413
ucgtcgtgtc gtt                                                    13

<210> 414
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 3,4 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 414
ucgtcgtgtc gtt                                                    13

<210> 415
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4,5 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 415
ucgtcgtgtc gtt                                                    13

<210> 416
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 5,6 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 416
ucgtcgtgtc gtt                                                    13

<210> 417
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 6,7 
<223> linked by X3 abasic spacer as described in
 Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 417
ucgtcgtgtc gtt                                                    13

<210> 418
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 7,8 
<223> linked by X3 abasic spacer as described in
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 418
ucgtcgtgtc gtt                                                    13

<210> 419
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 8,9 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 419
ucgtcgtgtc gtt                                                    13

<210> 420
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 9,10 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 420
ucgtcgtgtc gtt                                                    13

<210> 421
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 10,11 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 421
ucgtcgtgtc gtt                                                    13

<210> 422
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 11,12 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 422
ucgtcgtgtc gtt                                                    13

<210> 423
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 12,13 
<223> linked by X3 abasic spacer as described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 423
ucgtcgtgtc gtt                                                    13

<210> 424
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by X3 abasic spacer described in 
Table 2 of the specification

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 424
ucgtcgtgtc gtt                                                    13

<210> 425
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 425
ucgtcgtgtc gtt                                                    13

<210> 426
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5-iodo-2'-deoxycytidine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 426
ccgtcgtgtc gtt                                                    13

<210> 427
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1
<223> 5'-5' cap based on 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 427
ucgtcgtgtc gtt                                                    13

<210> 428
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1 
<223> 5'-5' cap based on 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 428
ucgtcgtgtc gtt                                                    13

<210> 429
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5'-orthodisulfide phosphodiester

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'- phosphorothioate)

<400> 429
ucgtcgtgtc gtt                                                    13

<210> 430
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5'-phosphate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine (3'-phosphorothioate)

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'- phosphorothioate)

<400> 430
ucgtcgtgtc gtt                                                    13

<210> 431
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5'-orthodisulfide phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'- phosphorothioate)

<400> 431
ucgtcgtgtc gtt                                                    13

<210> 432
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'- phosphorothioate)

<400> 432
ucgtcgtgtc gtt                                                    13

<210> 433
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 1 
<223> Rp conformation

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 433
ucgtcgtgtc gtt                                                    13

<210> 434
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 1 
<223> Sp conformation

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 434
ucgtcgtgtc gtt                                                    13

<210> 435
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2  
<223> Rp conformation

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 435
ucgtcgtgtc gtt                                                    13

<210> 436
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2 
<223> Sp conformation

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 436
ucgtcgtgtc gtt                                                    13

<210> 437
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 1 
<223> Sp conformation

<220> 
<221> misc_feature   
<222> 2 
<223> Rp conformation

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 437
ucgtcgtgtc gtt                                                    13

<210> 438
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 1,2 
<223> Sp conformation

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 438
ucgtcgtgtc gtt                                                    13

<210> 439
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 439
ucgtcgtgtc gtt                                                    13

<210> 440
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 10 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2, 10 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 440
ucgtcgtgtc gtt                                                    13

<210> 441
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,6,7,8,9,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 5, 10 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2, 5, 10 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 441
ucgtcgtgtc gtt                                                    13

<210> 442
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 12 
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)


<400> 442
ucgtcgtgtc gtt                                                    13

<210> 443
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,8,9,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 7, 12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> cytidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 4 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 7, 12
<223> thymidine having a 3' ethyl triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphate)

<400> 443
ucgtcgtgtc gtt                                                    13

<210> 444
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 1 
<223> biotinylated

<220> 
<221> misc_feature   
<222> 1,2,5,7,10,13 
<223> 2'-fluoro-adenosine

<220> 
<221> misc_feature   
<222> 3,6,8,11 
<223> 2'-fluoro-cytosine

<220> 
<221> misc_feature   
<222> 4,9,12 
<223> 2'-fluoro-guanine

<400> 444
aacgacacga cga                                                    13

<210> 445
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,10,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> dC O-silyltriester

<220> 
<221> misc_feature   
<222> 4 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 445
ucgtcgtgtc gtt                                                    13

<210> 446
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4, 12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 12 
<223> dT O-silyltriester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 446
ucgtcgtgtc gtt                                                    13

<210> 447
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,6,7,8,9,11,12,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 5, 10 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2, 5, 10 
<223> dC O-silyltriester

<220> 
<221> misc_feature   
<222> 4 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 447
ucgtcgtgtc gtt                                                    13

<210> 448
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,7,8,9,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> dC O-silyltriester

<220> 
<221> misc_feature   
<222> 4 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 12 
<223> dT O-silyltriester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 448
ucgtcgtgtc gtt                                                    13

<210> 449
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,3,5,6,8,9,10,11,13 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2, 4, 7, 12 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 2 
<223> dC O-silyltriester

<220> 
<221> misc_feature   
<222> 4 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 7, 12 
<223> dT O-silyltriester

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 449
ucgtcgtgtc gtt                                                    13

<210> 450
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 14 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 450
tucgtcgtga cgtt                                                   14

<210> 451
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 14 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 451
tucgacgtga cgtt                                                   14

<210> 452
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 9 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 9 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 452
tucgacgtt                                                         9

<210> 453
<211> 7
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(7) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 7 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 7 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 453
tuacgtt                                                           7

<210> 454
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 6 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 6 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 454
tacgtt                                                            6

<210> 455
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 6 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 455
tucgtt                                                            6

<210> 456
<211> 5
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 5 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 5 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 456
tacgt                                                             5

<210> 457
<211> 5
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(5) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 5 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 5 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 457
tucgt                                                             5

<210> 458
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2, 5 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 14 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 458
tucgucgtga cgtt                                                   14

<210> 459
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(9) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2,5 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 9 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 9 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 459
tucgucgtt                                                         9

<210> 460
<211> 7
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(7) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2, 6 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 7 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 7 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 460
tuacgut                                                           7

<210> 461
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 5 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 6 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 461
tacgut                                                            6

<210> 462
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2, 5 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 6 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 462
tucgut                                                            6

<210> 463
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 6 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 463
gucgtt                                                            6

<210> 464
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 6 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 6 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 464
gacgtt                                                            6

<210> 465
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2, 5 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 6 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 465
gucgut                                                            6

<210> 466
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 5 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6 
<223> dT PEG2-NH2 triester

<220> 
<221> misc_feature   
<222> 6 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 466
gacgut                                                            6

<210> 467
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 467
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 468
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 468
agcagcaaaa cagcaaaaca gcaa                                        24

<210> 469
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 5 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 469
tucgtcgtga cgtt                                                   14

<210> 470
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9,10,11 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 11 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 470
ucgtcgtgtc g                                                      11

<210> 471
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7,8,9 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 9 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 471
ucgtcgtgt                                                         9

<210> 472
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(8) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 9 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 9 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 9 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 472
ucgtcgtgt                                                         9

<210> 473
<211> 7
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5,6,7 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 7
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 473
ucgtcgt                                                           7

<210> 474
<211> 7
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(6) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 7 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 7 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 7 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 474
ucgtcgt                                                           7

<210> 475
<211> 5
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1,2,3,5 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 4 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 5 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 475
ucgtt                                                             5

<210> 476
<211> 5
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(4) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 5 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 5 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 5 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 476
ucgtt                                                             5

<210> 477
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 5 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 13, 14 
<223> 2'-OMe thymidine

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 477
tucgtcgtga cgtt                                                   14

<210> 478
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(15) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1, 2 
<223> 2'-OMe thymidine

<220> 
<221> misc_feature   
<222> 3 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 15 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 478
ttucgtcgtg acgtt                                                  15

<210> 479
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(15) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1, 2, 14, 15 
<223> 2'-OMe thymidine

<220> 
<221> misc_feature   
<222> 3 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 15 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 479
ttucgtcgtg acgtt                                                  15

<210> 480
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 5
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 13, 14
<223> 2'-OMOE thymidine

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 480
tucgtcgtga cgtt                                                   14

<210> 481
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(15) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1, 2 
<223> 2'-OMOE thymidine

<220> 
<221> misc_feature   
<222> 3 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 15 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 481
ttucgtcgtg acgtt                                                  15

<210> 482
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 3 
<223> Rp conformation

<220> 
<221> misc_feature   
<222> 5 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 482
tucgtcgtga cgtt                                                   14

<210> 483
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 3 
<223> Sp conformation

<220> 
<221> misc_feature   
<222> 5 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 483
tucgtcgtga cgtt                                                   14

<210> 484
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2 
<223> Rp conformation

<220> 
<221> misc_feature   
<222> 5 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 484
tucgtcgtga cgtt                                                   14

<210> 485
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(14) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 2 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 2 
<223> Sp conformation

<220> 
<221> misc_feature   
<222> 5 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 14 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 485
tucgtcgtga cgtt                                                   14

<210> 486
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(15)
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1, 2, 14, 15 
<223> 2'-OMOE thymidine

<220> 
<221> misc_feature   
<222> 3 
<223> 5-iodo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 6 
<223> DBCO-C6-dT

<220> 
<221> misc_feature   
<222> 15 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 486
ttucgtcgtg acgtt                                                  15

<210> 487
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 13 
<223> 2'-OMOE thymidine

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 487
ucgtcgtgtc gtt                                                    13

<210> 488
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(13) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 12, 13 
<223> 2'-OMOE thymidine

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate)

<400> 488
ucgtcgtgtc gtt                                                    13

<210> 489
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> (1)..(12) 
<223> nucleoside-3'-phosphorothioate

<220> 
<221> misc_feature   
<222> 1 
<223> 5-bromo-2'-deoxyuridine

<220> 
<221> misc_feature   
<222> 4 
<223> nucleoside having a 3' PEG2-NH2 triester (N1)

<220> 
<221> misc_feature   
<222> 12 
<223> 2'-OMOE thymidine

<220> 
<221> misc_feature   
<222> 13 
<223> nucleoside-3'-phosphate

<220> 
<221> misc_feature   
<222> 13 
<223> modified by C3 spacer (-(CH2)3-OH) (3'-phosphorothioate) 

<400> 489
ucgtcgtgtc gtt                                                    13


<210> 490
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 490
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe
            20                  25                  30          
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Gly Ser Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
                85                  90                  95      
Asp Ser Thr Val Ser Trp Ser Gly Asp Phe Phe Asp Tyr Trp Gly Leu
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 491
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 491
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe
            20                  25                  30          
Ala Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Gly Ser Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
                85                  90                  95      
Asp Ser Thr Val Ser Trp Ser Gly Asp Phe Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 492
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 492
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe
            20                  25                  30          
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Gly Ser Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
                85                  90                  95      
Asp Ser Thr Val Ser Trp Ser Gly Asp Phe Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 493
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 493
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe
            20                  25                  30          
Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Gly Ser Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
                85                  90                  95      
Asp Ser Thr Val Ser Trp Ser Gly Asp Phe Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 494
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 494
Asp Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe
            20                  25                  30          
Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Gly Ser Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
                85                  90                  95      
Asp Ser Thr Val Ser Trp Ser Gly Asp Phe Phe Asp Tyr Trp Gly Leu
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 495
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 495
Asp Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe
            20                  25                  30          
Ala Val Thr Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Gly Ser Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
                85                  90                  95      
Asp Ser Thr Val Ser Trp Ser Gly Asp Phe Phe Asp Tyr Trp Gly Leu
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 496
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 496
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Asn Val Lys Asn Asp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Arg Ile Arg Glu Thr Gly Ile Pro Glu Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asp Trp Pro Pro
                85                  90                  95      
Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 497
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 497
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Val Lys Asn Asp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Arg Ile Arg Glu Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asp Trp Pro Pro
                85                  90                  95      
Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 498
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 498
Gly Phe Ser Phe Ser Asn Phe Ala Met Thr
 1               5                  10  


<210> 499
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 499
Gly Phe Ser Phe Ser Asn Phe Ala Val Thr
 1               5                  10  


<210> 500
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 500
Gly Phe Ser Phe Ser Asn Phe Ala Leu Thr
 1               5                  10  


<210> 501
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 501
Thr Ile Gly Ser Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15  


<210> 502
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 502
Asp Ser Thr Val Ser Trp Ser Gly Asp Phe Phe Asp Tyr
 1               5                  10              


<210> 503
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 503
Arg Ala Ser Gln Asn Val Lys Asn Asp Leu Ala
 1               5                  10      


<210> 504
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 504
Ala Ala Arg Ile Arg Glu Thr
 1               5          


<210> 505
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 505
Gln Gln Tyr Tyr Asp Trp Pro Pro Phe Thr
 1               5                  10  


<210> 506
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 506
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ile Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Gly Ala Asp Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
                85                  90                  95      
Asp Ser Thr Val Gly Trp Ser Gly Asp Phe Phe Asp Tyr Trp Gly Leu
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 507
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 507
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ile Tyr
            20                  25                  30          
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Gly Ala Asp Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
                85                  90                  95      
Asp Ser Thr Val Gly Trp Ser Gly Asp Phe Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 508
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 508
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ile Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Gly Ala Asp Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
                85                  90                  95      
Asp Ser Thr Val Gly Trp Ser Gly Asp Phe Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 509
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 509
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ile Tyr
            20                  25                  30          
Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Gly Ala Asp Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
                85                  90                  95      
Asp Ser Thr Val Gly Trp Ser Gly Asp Phe Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 510
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 510
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Thr Phe Ser Cys Arg Ala Ser Gln Asn Val Arg Ser Asp
            20                  25                  30          
Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Arg Asp Thr Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Tyr Asp Trp Pro Pro
                85                  90                  95      
Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 511
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 511
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Asn Val Arg Ser Asp
            20                  25                  30          
Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Arg Asp Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Tyr Asp Trp Pro Pro
                85                  90                  95      
Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 512
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 512
Gly Phe Ser Phe Ser Ile Tyr Ala Met Ser
 1               5                  10  


<210> 513
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 513
Gly Phe Ser Phe Ser Ile Tyr Ala Val Ser
 1               5                  10  


<210> 514
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 514
Gly Phe Ser Phe Ser Ile Tyr Ala Leu Ser
 1               5                  10  


<210> 515
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 515
Thr Ile Gly Ala Asp Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15  


<210> 516
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 516
Asp Ser Thr Val Gly Trp Ser Gly Asp Phe Phe Asp Tyr
 1               5                  10              


<210> 517
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 517
Arg Ala Ser Gln Asn Val Arg Ser Asp Ile Ala
 1               5                  10      


<210> 518
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 518
Ala Ala Ser Ser Arg Asp Thr
 1               5          


<210> 519
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 519
Gln Gln Tyr Tyr Asp Trp Pro Pro Phe Thr
 1               5                  10  


<210> 520
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 520
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Ala Gly Ile Ser Ala Gly Gly Ser Asp Thr Tyr Tyr Pro Ala Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Thr Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Thr Trp Asn His Leu Phe Asp Tyr Trp Gly Leu Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 521
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 521
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Ser Ala Gly Gly Ser Asp Thr Tyr Tyr Pro Ala Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Thr Trp Asn His Leu Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 522
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 522
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn
            20                  25                  30          
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Ser Ala Gly Gly Ser Asp Thr Tyr Tyr Pro Ala Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Thr Trp Asn His Leu Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 523
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 523
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn
            20                  25                  30          
Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Ser Ala Gly Gly Ser Asp Thr Tyr Tyr Pro Ala Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Thr Trp Asn His Leu Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 524
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 524
Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val
 1               5                  10                  15      
Lys Ile Ala Cys Ser Gly Gly Asp Tyr Tyr Ser Tyr Tyr Tyr Gly Trp
            20                  25                  30          
Tyr Gln Gln Lys Ala Pro Gly Ser Ala Leu Val Thr Val Ile Tyr Ser
        35                  40                  45              
Asp Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Ala
    50                  55                  60                  
Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp
65                  70                  75                  80  
Glu Ala Val Tyr Tyr Cys Gly Gly Tyr Asp Tyr Ser Thr Tyr Ala Asn
                85                  90                  95      
Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105         


<210> 525
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 525
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Ser Gly Gly Ser Tyr Ser Ser Tyr Tyr Tyr
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Leu Ile Tyr
        35                  40                  45              
Ser Asp Asp Lys Arg Pro Ser Asn Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Gly Tyr Asp Gln Ser Ser Tyr Thr
                85                  90                  95      
Asn Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 526
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 526
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
 1               5                  10                  15      
Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Tyr Ser Ser Tyr Tyr Tyr
            20                  25                  30          
Ala Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Thr Leu Ile Tyr
        35                  40                  45              
Ser Asp Asp Lys Arg Pro Ser Asn Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Gly Tyr Asp Gln Ser Ser Tyr Thr
                85                  90                  95      
Asn Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu
            100                 105             


<210> 527
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 527
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Ser Gly Gly Asp Tyr Tyr Ser Thr Tyr Tyr
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Val Ile His
        35                  40                  45              
Ser Asp Asp Lys Arg Pro Ser Asp Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Gly Tyr Asp Gly Arg Thr Tyr Ile
                85                  90                  95      
Asn Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 528
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 528
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
 1               5                  10                  15      
Lys Val Thr Ile Ser Cys Ser Gly Gly Asp Tyr Tyr Ser Thr Tyr Tyr
            20                  25                  30          
Ala Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Thr Val Ile His
        35                  40                  45              
Ser Asp Asp Lys Arg Pro Ser Asp Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Gly Tyr Asp Gly Arg Thr Tyr Ile
                85                  90                  95      
Asn Thr Phe Gly Thr Gly Thr Lys Val Thr Val Leu
            100                 105             


<210> 529
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 529
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
 1               5                  10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
            20                  25                  30          
Ser Ser Tyr Tyr Tyr Ala Trp Tyr Gln Gln His Pro Gly Lys Ala Pro
        35                  40                  45              
Lys Thr Leu Ile Tyr Ser Asp Asp Lys Arg Pro Ser Asn Val Ser Asn
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser
65                  70                  75                  80  
Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Gly Tyr Asp
                85                  90                  95      
Gln Ser Ser Tyr Thr Asn Pro Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105                 110         
Leu
    


<210> 530
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 530
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
 1               5                  10                  15      
Lys Val Thr Ile Ser Cys Ser Gly Gly Asp Tyr Tyr Ser Tyr Tyr Tyr
            20                  25                  30          
Gly Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Thr Val Ile Tyr
        35                  40                  45              
Ser Asp Asp Lys Arg Pro Ser Asp Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Gly Tyr Asp Tyr Ser Thr Tyr Ala
                85                  90                  95      
Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu
            100                 105             


<210> 531
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 531
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Ser Gly Gly Ala Tyr Ser Ser Tyr Tyr Tyr
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
        35                  40                  45              
Ser Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Gly Tyr Asp Gln Ser Ser Tyr Thr
                85                  90                  95      
Asn Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 532
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 532
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Ser Gly Gly Ala Tyr Ser Ser Tyr Tyr Tyr
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
        35                  40                  45              
Ser Asp Asp Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Gly Tyr Asp Gln Ser Ser Tyr Thr
                85                  90                  95      
Asn Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 533
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 533
Gly Phe Thr Phe Ser Ser Asn Ala Leu Ser
 1               5                  10  


<210> 534
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 534
Gly Phe Thr Phe Ser Ser Asn Ala Met Ser
 1               5                  10  


<210> 535
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 535
Gly Phe Thr Phe Ser Ser Asn Ala Val Ser
 1               5                  10  


<210> 536
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 536
Ile Ser Ala Gly Gly Ser Asp Thr
 1               5              


<210> 537
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 537
Ala Arg Glu Thr Trp Asn His Leu Phe Asp Tyr
 1               5                  10      


<210> 538
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 538
Ser Gly Gly Asp Tyr Tyr Ser Tyr Tyr Tyr Gly
 1               5                  10      


<210> 539
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 539
Ser Gly Gly Ser Tyr Ser Ser Tyr Tyr Tyr Ala
 1               5                  10      


<210> 540
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 540
Ser Gly Gly Asp Tyr Tyr Ser Thr Tyr Tyr Ala
 1               5                  10      


<210> 541
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 541
Gly Ser Tyr Ser Ser Tyr Tyr Tyr Ala
 1               5                  


<210> 542
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 542
Ser Gly Gly Ala Tyr Ser Ser Tyr Tyr Tyr Ala
 1               5                  10      


<210> 543
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 543
Ser Asp Asp Lys Arg Pro Ser
 1               5          


<210> 544
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 544
Gly Gly Tyr Asp Tyr Ser Thr Tyr Ala Asn Ala
 1               5                  10      


<210> 545
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 545
Gly Gly Tyr Asp Gln Ser Ser Tyr Thr Asn Pro
 1               5                  10      


<210> 546
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 546
Gly Gly Tyr Asp Gly Arg Thr Tyr Ile Asn Thr
 1               5                  10      


<210> 547
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 547
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Asn Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val
        35                  40                  45              
Ser Leu Ile Ser Gly Ser Gly Glu Ile Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Asn Asn Arg Tyr Arg Phe Phe Asp Asp Trp Gly Leu Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 548
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 548
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Leu Ile Ser Gly Ser Gly Glu Ile Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Asn Asn Arg Tyr Arg Phe Phe Asp Asp Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 549
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 549
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Leu Ile Ser Gly Ser Gly Glu Ile Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Asn Asn Arg Tyr Arg Phe Phe Asp Asp Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 550
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 550
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Leu Ile Ser Gly Ser Gly Glu Ile Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Asn Asn Arg Tyr Arg Phe Phe Asp Asp Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 551
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 551
Glu Thr Val Leu Thr Gln Ser Pro Gly Thr Leu Thr Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Thr Cys Arg Ala Ser Gln Ser Val Tyr Thr Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Glu Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asp Arg Pro Pro
                85                  90                  95      
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 552
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 552
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Tyr Thr Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asp Arg Pro Pro
                85                  90                  95      
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 553
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 553
Glu Thr Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Tyr Thr Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asp Arg Pro Pro
                85                  90                  95      
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 554
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 554
Gly Phe Thr Phe Ser Ser Tyr Asp Met Asn
 1               5                  10  


<210> 555
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 555
Gly Phe Thr Phe Ser Ser Tyr Asp Val Asn
 1               5                  10  


<210> 556
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 556
Gly Phe Thr Phe Ser Ser Tyr Asp Leu Asn
 1               5                  10  


<210> 557
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 557
Leu Ile Ser Gly Ser Gly Glu Ile Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 558
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 558
Glu Asn Asn Arg Tyr Arg Phe Phe Asp Asp
 1               5                  10  


<210> 559
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 559
Arg Ala Ser Gln Ser Val Tyr Thr Tyr Leu Ala
 1               5                  10      


<210> 560
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 560
Gly Ala Ser Ser Arg Ala Thr
 1               5          


<210> 561
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 561
Gln Gln Tyr Tyr Asp Arg Pro Pro Leu Thr
 1               5                  10  


<210> 562
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 562
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
 1               5                  10                  15      
Ser Ile Thr Ile Ser Cys Phe Gly Ser Ser Gly Asn Tyr Gly Leu Val
            20                  25                  30          
Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr
        35                  40                  45              
Tyr Asn Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser
    50                  55                  60                  
Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Glu Thr Gly Ser Ala Thr
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105     


<210> 563
<211> 103
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 563
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15      
Thr Ala Ser Ile Thr Cys Phe Gly Ser Ser Gly Asn Tyr Gly Trp Tyr
            20                  25                  30          
Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Tyr Asn Asn
        35                  40                  45              
Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly
    50                  55                  60                  
Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala
65                  70                  75                  80  
Asp Tyr Tyr Cys Gly Ala Trp Glu Thr Gly Ser Ala Thr Phe Gly Gly
                85                  90                  95      
Gly Thr Lys Leu Thr Val Leu
            100             


<210> 564
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 564
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 565
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 565
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 566
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 566
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 567
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 567
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 568
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 568
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 569
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 569
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 570
<211> 326
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 570
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    130                 135                 140                 
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 571
<211> 326
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 571
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    130                 135                 140                 
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 572
<211> 326
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 572
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    130                 135                 140                 
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 573
<211> 326
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 573
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    130                 135                 140                 
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 574
<211> 326
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 574
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala
    130                 135                 140                 
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 575
<211> 327
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 575
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 576
<211> 327
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 576
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Ala Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 577
<211> 327
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 577
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 578
<211> 327
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 578
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 579
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 579
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105         


<210> 580
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 580
Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser
 1               5                  10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro
        35                  40                  45              
Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
65                  70                  75                  80  
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
                85                  90                  95      
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
            100                 105     


<210> 581
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 581
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
 1               5                  10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
        35                  40                  45              
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
65                  70                  75                  80  
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
                85                  90                  95      
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
            100                 105     


<210> 582
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 582
Leu Leu Gln Gly Gly
 1               5  


<210> 583
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 583
Gly Gly Gly Leu Leu Gln Gly Gly
 1               5              


<210> 584
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 584
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Glu
 1               5                  10                  15      
Ser Leu Thr Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30          
Thr Met Asn Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Asp Trp Val
        35                  40                  45              
Ser Ser Ile Ser Thr Ser Gly Val Ile Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Arg Leu Phe Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Thr Asp Thr Phe Asp His Trp Gly Pro Gly Thr Leu Val Thr Val
            100                 105                 110         
Ser Ser
        


<210> 585
<211> 102
<212> PRT
<213> Gallus gallus domesticus

<400> 585
Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Phe Gly Ser Ser Gly Asn Tyr Gly Trp Phe Gln Gln
            20                  25                  30          
Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile His Tyr Asn Asn Lys
        35                  40                  45              
Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser
    50                  55                  60                  
Thr Gly Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val
65                  70                  75                  80  
Tyr Phe Cys Gly Ala Trp Glu Thr Gly Ser Ala Thr Phe Gly Ala Gly
                85                  90                  95      
Thr Thr Leu Thr Val Leu
            100         


<210> 586
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1
<223> absent or 2'-deoxythymidine

<220> 
<221> misc_feature   
<222> 2
<223> a 2'-deoxyribonucleotide with a modified nucleobase

<220> 
<221> misc_feature   
<222> 3, 6, 11
<223> 2'-deoxycytidine

<220> 
<221> misc_feature   
<222> 4, 7, 9, 12
<223> 2'-deoxyguanosine

<220> 
<221> misc_feature   
<222> 5
<223> 2'-deoxyadenosine or 2'-deoxythymidine, each optionally 
comprising a 3'-phosphotriester

<220> 
<221> misc_feature   
<222> 8
<223> Can be in repeats of about 1 to about 4

<220> 
<221> misc_feature   
<222> 10
<223> 2'-deoxyadenosine or 2'-deoxythymidine

<220> 
<221> misc_feature   
<222> 13
<223> 2'-deoxythymidine optionally comprising a 3'-phosphotriester

<400> 586
nncgncgtgn cgnt                                                  14
