                         SEQUENCE LISTING

<110>  Intellia Therapeutics, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY

<130>  01155-0026-00PCT

<150>  US 62/746,522
<151>  2018-10-16

<150>  US 62/747,037
<151>  2018-10-17

<160>  283 

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  1
ggcucucgga gaaugacgag                                                   20


<210>  2
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  2
ggccucggcg cugacgaucu                                                   20


<210>  3
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  3
augacgagug gacccaggau                                                   20


<210>  4
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  4
agaagguggc cgagacccuc                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  5
ugagggucuc ggccaccuuc                                                   20


<210>  6
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  6
agagaucucc cacacccaaa                                                   20


<210>  7
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  7
uggcucaaac acagcgaccu                                                   20


<210>  8
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  8
ggcgcugacg aucuggguga                                                   20


<210>  9
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  9
uggcagacag gaccccuugc                                                   20


<210>  10
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  10
ugacgagugg acccaggaua                                                   20


<210>  11
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  11
agacaggacc ccuugcuggu                                                   20


<210>  12
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  12
uugacagcgg aagugguugc                                                   20


<210>  13
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  13
cguagaacug gacuugacag                                                   20


<210>  14
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  14
cgcugucaag uccaguucua                                                   20


<210>  15
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  15
acuggacuug acagcggaag                                                   20


<210>  16
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  16
guugcggggg uucugccaga                                                   20


<210>  17
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  17
cugccugagc agccgccuga                                                   20


<210>  18
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  18
gacagcggaa gugguugcgg                                                   20


<210>  19
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  19
ccacucaccu gcucuacccc                                                   20


<210>  20
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  20
gcugucaagu ccaguucuac                                                   20


<210>  21
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  21
acacuggugu gccuggccac                                                   20


<210>  22
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  22
agacccucag gcggcugcuc                                                   20


<210>  23
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  23
augggaagga ggugcacagu                                                   20


<210>  24
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  24
agggcgggcu gcuccuugag                                                   20


<210>  25
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  25
ucccuagcaa gaucucauag                                                   20


<210>  26
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  26
ggugcacagu ggggucagca                                                   20


<210>  27
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  27
ccagcucagc uccacguggu                                                   20


<210>  28
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  28
ccgcaaccac uuccgcuguc                                                   20


<210>  29
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  29
guccacucgu cauucuccga                                                   20


<210>  30
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  30
gcccguagaa cuggacuuga                                                   20


<210>  31
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  31
ucacccagau cgucagcgcc                                                   20


<210>  32
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  32
ggguccacuc gucauucucc                                                   20


<210>  33
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  33
uccaguucua cgggcucucg                                                   20


<210>  34
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  34
cggagaauga cgaguggacc                                                   20


<210>  35
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  35
accacuuccg cugucaaguc                                                   20


<210>  36
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  36
aaugacgagu ggacccagga                                                   20


<210>  37
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  37
acgggcucuc ggagaaugac                                                   20


<210>  38
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  38
gacuccagau acugccugag                                                   20


<210>  39
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  39
cgcuguguuu gagccaucag                                                   20


<210>  40
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  40
agaacuggac uugacagcgg                                                   20


<210>  41
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  41
gagacccuca ggcggcugcu                                                   20


<210>  42
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  42
cgucauucuc cgagagcccg                                                   20


<210>  43
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  43
cagcccgccc ucaaugacuc                                                   20


<210>  44
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  44
ggcugcucag gcaguaucug                                                   20


<210>  45
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  45
agugguugcg gggguucugc                                                   20


<210>  46
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  46
ggucgcugug uuugagccau                                                   20


<210>  47
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  47
gaucucauag aggauggugg                                                   20


<210>  48
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  48
uguuugagcc aucagaagca                                                   20


<210>  49
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  49
uacugccuga gcagccgccu                                                   20


<210>  50
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  50
acccgcagcc ccucaaggag                                                   20


<210>  51
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  51
aggcaguauc uggagucauu                                                   20


<210>  52
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  52
uguguuugag ccaucagaag                                                   20


<210>  53
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  53
gguugcgggg guucugccag                                                   20


<210>  54
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  54
gggucucggc caccuucugg                                                   20


<210>  55
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  55
cagaaggugg ccgagacccu                                                   20


<210>  56
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  56
cgccgaggcc ugggguagag                                                   20


<210>  57
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  57
gguucugcca gaagguggcc                                                   20


<210>  58
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  58
cagagaucuc ccacacccaa                                                   20


<210>  59
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  59
uugagggcgg gcugcuccuu                                                   20


<210>  60
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  60
aagccugugg ccaggcacac                                                   20


<210>  61
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  61
cagcgccgag gccuggggua                                                   20


<210>  62
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  62
cccacucacc ugcucuaccc                                                   20


<210>  63
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  63
ugucugccac cauccucuau                                                   20


<210>  64
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  64
ugcuucugau ggcucaaaca                                                   20


<210>  65
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  65
uucccauuca cccaccagcu                                                   20


<210>  66
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  66
gucagcgccg aggccugggg                                                   20


<210>  67
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  67
cccucaggcg gcugcucagg                                                   20


<210>  68
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  68
aaugacucca gauacugccu                                                   20


<210>  69
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  69
cacacuggug ugccuggcca                                                   20


<210>  70
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  70
ucauagagga ugguggcaga                                                   20


<210>  71
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  71
cacccagauc gucagcgccg                                                   20


<210>  72
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  72
ugacagcgga agugguugcg                                                   20


<210>  73
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  73
ucuccgagag cccguagaac                                                   20


<210>  74
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  74
aguccaguuc uacgggcucu                                                   20


<210>  75
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  75
aucgucagcg ccgaggccug                                                   20


<210>  76
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  76
aaggaggugc acaguggggu                                                   20


<210>  77
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  77
uaucuggagu cauugagggc                                                   20


<210>  78
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  78
gcggggguuc ugccagaagg                                                   20


<210>  79
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  79
cuugacagcg gaagugguug                                                   20


<210>  80
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  80
guguggccuu uugggugugg                                                   20


<210>  81
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  81
gaucgucagc gccgaggccu                                                   20


<210>  82
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  82
uguggccagg cacaccagug                                                   20


<210>  83
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  83
aggccucggc gcugacgauc                                                   20


<210>  84
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  84
gugaauggga aggaggugca                                                   20


<210>  85
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  85
gcggcugcuc aggcaguauc                                                   20


<210>  86
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  86
acugccugag cagccgccug                                                   20


<210>  87
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  87
aaaggccaca cuggugugcc                                                   20


<210>  88
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  88
ugagggcggg cugcuccuug                                                   20


<210>  89
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  89
gagcagccgc cugagggucu                                                   20


<210>  90
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  90
cucucagcug guacacggca                                                   20


<210>  91
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  91
uucggaaccc aaucacugac                                                   20


<210>  92
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  92
uaaacccggc cacuuucagg                                                   20


<210>  93
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  93
gauuaaaccc ggccacuuuc                                                   20


<210>  94
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  94
cgucaugagc agauuaaacc                                                   20


<210>  95
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  95
agagucucuc agcugguaca                                                   20


<210>  96
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  96
acacggcagg gucaggguuc                                                   20


<210>  97
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  97
ucucucagcu gguacacggc                                                   20


<210>  98
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  98
uggauuuaga gucucucagc                                                   20


<210>  99
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  99
gagaaucaaa aucggugaau                                                   20


<210>  100
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  100
acaaaacugu gcuagacaug                                                   20


<210>  101
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  101
ugugcuagac augaggucua                                                   20


<210>  102
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  102
gcaccaaagc ugcccuuacc                                                   20


<210>  103
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  103
aaguuccugu gaugucaagc                                                   20


<210>  104
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  104
cucgaccagc uugacaucac                                                   20


<210>  105
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  105
auccuccucc ugaaaguggc                                                   20


<210>  106
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  106
acccggccac uuucaggagg                                                   20


<210>  107
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  107
uuaaucugcu caugacgcug                                                   20


<210>  108
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  108
acacggauga acaauaaggc                                                   20


<210>  109
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  109
acuuacacgg augaacaaua                                                   20


<210>  110
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  110
gcugguacac ggcaggguca                                                   20


<210>  111
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  111
ggaagcuaca uaccuacauu                                                   20


<210>  112
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  112
uccucacugu gugcaucagg                                                   20


<210>  113
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  113
cugguuccuc uuccaaaugu                                                   20


<210>  114
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  114
aaagucagau uuguugcucc                                                   20


<210>  115
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  115
uucaaaaccu gucagugauu                                                   20


<210>  116
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  116
ugcucaugac gcugcggcug                                                   20


<210>  117
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  117
ucaaggcccc ucaccucagc                                                   20


<210>  118
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  118
ggcguuugca caugcaaagu                                                   20


<210>  119
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  119
gaccacagcc gcagcgucau                                                   20


<210>  120
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  120
augacgcugc ggcugugguc                                                   20


<210>  121
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  121
auucggaacc caaucacuga                                                   20


<210>  122
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  122
aacccggcca cuuucaggag                                                   20


<210>  123
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  123
uuaaacccgg ccacuuucag                                                   20


<210>  124
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  124
agauuuguug cuccaggcca                                                   20


<210>  125
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  125
ugagaaucaa aaucggugaa                                                   20


<210>  126
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  126
gaugucaagc uggucgagaa                                                   20


<210>  127
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  127
guuucaaagc uuuucucgac                                                   20


<210>  128
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  128
ugaaggcguu ugcacaugca                                                   20


<210>  129
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  129
acccugaccc ugccguguac                                                   20


<210>  130
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  130
agcuucaagg ccccucaccu                                                   20


<210>  131
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  131
guuccgaauc cuccuccuga                                                   20


<210>  132
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  132
agauuaaacc cggccacuuu                                                   20


<210>  133
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  133
cccugccgug uaccagcuga                                                   20


<210>  134
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  134
ucacuggauu uagagucucu                                                   20


<210>  135
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  135
uacuuacacg gaugaacaau                                                   20


<210>  136
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  136
uaucacagac aaaacugugc                                                   20


<210>  137
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  137
ccacagcacu guugcucuug                                                   20


<210>  138
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  138
ccugugaugu caagcugguc                                                   20


<210>  139
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  139
acaugagguc uauggacuuc                                                   20


<210>  140
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  140
acuguugcuc uugaagucca                                                   20


<210>  141
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  141
agcuacauac cuacauuugg                                                   20


<210>  142
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  142
uagaaaguuc cugugauguc                                                   20


<210>  143
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  143
ucacugugug caucaggagg                                                   20


<210>  144
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  144
gacaaaacug ugcuagacau                                                   20


<210>  145
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  145
cuucaacaac agcauuauuc                                                   20


<210>  146
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  146
caacaacagc auuauuccag                                                   20


<210>  147
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  147
ucucaaacaa augugucaca                                                   20


<210>  148
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  148
augaggucua uggacuucaa                                                   20


<210>  149
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  149
gacccugccg uguaccagcu                                                   20


<210>  150
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  150
ccccugucuu accuguuuca                                                   20


<210>  151
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  151
agcaacagug cuguggccug                                                   20


<210>  152
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  152
cuacauaccu acauuuggaa                                                   20


<210>  153
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  153
acuuugugac acauuuguuu                                                   20


<210>  154
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  154
aucacagaca aaacugugcu                                                   20


<210>  155
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  155
uucaacaaca gcauuauucc                                                   20


<210>  156
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  156
caugaggucu auggacuuca                                                   20


<210>  157
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  157
gcuacauacc uacauuugga                                                   20


<210>  158
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  158
cucuuguccc acagauaucc                                                   20


<210>  159
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  159
gauucugaug uguauaucac                                                   20


<210>  160
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  160
cugugauguc aagcuggucg                                                   20


<210>  161
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  161
ccugccgugu accagcugag                                                   20


<210>  162
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  162
acauaccuac auuuggaaga                                                   20


<210>  163
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  163
ccucacugug ugcaucagga                                                   20


<210>  164
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  164
acaaaugugu cacaaaguaa                                                   20


<210>  165
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  165
gagcaacagu gcuguggccu                                                   20


<210>  166
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  166
ucgaccagcu ugacaucaca                                                   20


<210>  167
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  167
auuaaacccg gccacuuuca                                                   20


<210>  168
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  168
cacggcaggg ucaggguucu                                                   20


<210>  169
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  169
aaacccggcc acuuucagga                                                   20


<210>  170
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  170
caaggccccu caccucagcu                                                   20


<210>  171
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  171
cccggccacu uucaggagga                                                   20


<210>  172
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  172
cauuucuaua auacuuacac                                                   20


<210>  173
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  173
acagccgcag cgucaugagc                                                   20


<210>  174
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  174
aucaaaaucg gugaauaggc                                                   20


<210>  175
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  175
gcguuugcac augcaaaguc                                                   20


<210>  176
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  176
cuguugcucu ugaaguccau                                                   20


<210>  177
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  177
aaaucgguga auaggcagac                                                   20


<210>  178
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  178
uugucuguga uauacacauc                                                   20


<210>  179
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  179
ggcucucgga gaaugacgag guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  180
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  180
ggccucggcg cugacgaucu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  181
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  181
augacgagug gacccaggau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  182
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  182
agaagguggc cgagacccuc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  183
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  183
ugagggucuc ggccaccuuc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  184
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  184
agagaucucc cacacccaaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  185
<211>  42
<212>  RNA
<213>  Homo sapiens

<400>  185
ucaggguucu ggauaucugu guuuuagagc uaugcuguuu ug                          42


<210>  186
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  186
cucucagcug guacacggca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  187
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  187
uucggaaccc aaucacugac guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  188
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  188
uaaacccggc cacuuucagg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  189
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  189
gauuaaaccc ggccacuuuc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  190
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  190
cgucaugagc agauuaaacc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  191
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  191
agagucucuc agcugguaca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  192
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  192
ucaggguucu ggauaucugu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  193
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substtuted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  gm

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  am

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  gm

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substtuted for phosphorothioate (PS) bonds

<400>  193
gaguccgagc agaagaagaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  194
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substtuted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  gm

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  am

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substtuted for phosphorothioate (PS) bonds

<400>  194
gaguccgagc agaagaagaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  195
<211>  74
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  195
aacagcauag caaguuaaaa uaaggcuagu ccguuaucaa cuugaaaaag uggcaccgag       60

ucggugcuuu uuuu                                                         74


<210>  196
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  196
ggcucucgga gaaugacgag guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  197
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  197
ggccucggcg cugacgaucu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  198
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  198
augacgagug gacccaggau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  199
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  199
ugagggucuc ggccaccuuc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  200
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  200
agagaucucc cacacccaaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  201
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  am

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  cm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  am

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  201
acacggcagg gucaggguuc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  202
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  am

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  202
agcugguaca cggcaggguc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  203
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  cm

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  um

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  203
cucucagcug guacacggca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  204
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  cm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  um

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  204
ucucucagcu gguacacggc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  205
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  gm

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  205
uggauuuaga gucucucagc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  206
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  am

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  gm

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  206
uaggcagaca gacuugucac guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  207
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  cm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  um

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  207
ucugugggac aagaggauca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  208
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  am

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  um

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  208
aucuguggga caagaggauc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  209
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  cm

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  um

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  gm

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  209
cuggauaucu gugggacaag guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  210
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  gm

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  um

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  210
gucaggguuc uggauaucug guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  211
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substituted for phosphorothioate (PS) bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  cm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  am

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substituted for phosphorothioate (PS) bonds

<400>  211
ucaggguucu ggauaucugu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  212
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  212
uaggcagaca gacuugucac guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  213
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  213
agcugguaca cggcaggguc                                                   20


<210>  214
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  214
uaggcagaca gacuugucac                                                   20


<210>  215
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  215
ucugugggac aagaggauca                                                   20


<210>  216
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  216
aucuguggga caagaggauc                                                   20


<210>  217
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  217
cuggauaucu gugggacaag                                                   20


<210>  218
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  218
gucaggguuc uggauaucug                                                   20


<210>  250
<211>  819
<212>  DNA
<213>  Homo sapiens

<400>  250
atggaaaccc tgctgaaggt gctgagcggc acactgctgt ggcagctgac atgggtccga       60

tctcagcagc ctgtgcagtc tcctcaggcc gtgattctga gagaaggcga ggacgccgtg      120

atcaactgca gcagctctaa ggccctgtac agcgtgcact ggtacagaca gaagcacggc      180

gaggcccctg tgttcctgat gatcctgctg aaaggcggcg agcagaaggg ccacgagaag      240

atcagcgcca gcttcaacga gaagaagcag cagtccagcc tgtacctgac agccagccag      300

ctgagctaca gcggcaccta cttttgtggc accgcctgga tcaacgacta caagctgtct      360

ttcggagccg gcaccacagt gacagtgcgg gccaatattc agaaccccga tcctgccgtg      420

taccagctga gagacagcaa gagcagcgac aagagcgtgt gcctgttcac cgacttcgac      480

agccagacca acgtgtccca gagcaaggac agcgacgtgt acatcaccga taagtgcgtg      540

ctggacatgc ggagcatgga cttcaagagc aacagcgccg tggcctggtc caacaagagc      600

gatttcgcct gcgccaacgc cttcaacaac agcattatcc ccgaggacac attcttccca      660

agtcctgaga gcagctgcga cgtgaagctg gtggaaaaga gcttcgagac agacaccaac      720

ctgaacttcc agaacctgag cgtgatcggc ttcagaatcc tgctgctcaa ggtggccggc      780

ttcaacctgc tgatgaccct gagactgtgg tccagctga                             819


<210>  251
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Glu Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu 
1               5                   10                  15      


Thr Trp Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile 
            20                  25                  30          


Leu Arg Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala 
        35                  40                  45              


Leu Tyr Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val 
    50                  55                  60                  


Phe Leu Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys 
65                  70                  75                  80  


Ile Ser Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu 
                85                  90                  95      


Thr Ala Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Ala 
            100                 105                 110         


Trp Ile Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  252
<211>  945
<212>  DNA
<213>  Homo sapiens

<400>  252
atgggatctt ggacactgtg ttgcgtgtcc ctgtgcatcc tggtggccaa gcacacagat       60

gccggcgtga tccagtctcc tagacacgaa gtgaccgaga tgggccaaga agtgaccctg      120

cgctgcaagc ctatcagcgg ccacgattac ctgttctggt acagacagac catgatgaga      180

ggcctggaac tgctgatcta cttcaacaac aacgtgccca tcgacgacag cggcatgccc      240

gaggatagat tcagcgccaa gatgcccaac gccagcttca gcaccctgaa gatccagcct      300

agcgagccca gagatagcgc cgtgtacttc tgcgccagca gaaagacagg cggctacagc      360

aatcagcccc agcactttgg agatggcacc cggctgagca tcctggaaga tctgaagaac      420

gtgttcccac ctgaggtggc cgtgttcgag ccttctgagg ccgagatcag ccacacacag      480

aaagccacac tcgtgtgtct ggccaccggc ttctatcccg atcacgtgga actgtcttgg      540

tgggtcaacg gcaaagaggt gcacagcggc gtctgtaccg atcctcagcc tctgaaagag      600

cagcccgctc tgaacgacag cagatactgc ctgagcagca gactgagagt gtccgccacc      660

ttctggcaga accccagaaa ccacttcaga tgccaggtgc agttctacgg cctgagcgag      720

aacgatgagt ggacccagga tagagccaag cctgtgacac agatcgtgtc tgccgaagcc      780

tggggcagag ccgattgtgg ctttaccagc gagagctacc agcagggcgt gctgtctgcc      840

acaatcctgt acgagatcct gctgggcaaa gccactctgt acgccgtgct ggtgtctgcc      900

ctggtgctga tggccatggt caagcggaag gatagcaggg gctga                      945


<210>  253
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Arg Lys Thr Gly Gly Tyr Ser Asn Gln Pro Gln His Phe Gly Asp 
        115                 120                 125             


Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  300
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified sgRNA


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  The 3 phosphodiester bonds between nucleotides 1 to 4 are 
       substtuted for phosphorothioate (PS) bonds

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  am

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  am

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  um

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  am

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  cm

<220>
<221>  modified_base
<222>  (68)..(69)
<223>  am

<220>
<221>  modified_base
<222>  (71)..(72)
<223>  um

<220>
<221>  modified_base
<222>  (73)..(73)
<223>  gm

<220>
<221>  modified_base
<222>  (74)..(78)
<223>  am

<220>
<221>  modified_base
<222>  (79)..(79)
<223>  gm

<220>
<221>  modified_base
<222>  (80)..(80)
<223>  um

<220>
<221>  modified_base
<222>  (81)..(82)
<223>  gm

<220>
<221>  modified_base
<222>  (83)..(83)
<223>  cm

<220>
<221>  modified_base
<222>  (84)..(84)
<223>  am

<220>
<221>  modified_base
<222>  (85)..(86)
<223>  cm

<220>
<221>  modified_base
<222>  (87)..(87)
<223>  gm

<220>
<221>  modified_base
<222>  (88)..(88)
<223>  am

<220>
<221>  modified_base
<222>  (89)..(89)
<223>  gm

<220>
<221>  modified_base
<222>  (90)..(90)
<223>  um

<220>
<221>  modified_base
<222>  (91)..(91)
<223>  cm

<220>
<221>  modified_base
<222>  (92)..(93)
<223>  gm

<220>
<221>  modified_base
<222>  (94)..(94)
<223>  um

<220>
<221>  modified_base
<222>  (95)..(95)
<223>  gm

<220>
<221>  modified_base
<222>  (96)..(96)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  um

<220>
<221>  modified_base
<222>  (97)..(100)
<223>  The 3 phosphodiester bonds between nucleotides 97 to 100 are 
       substtuted for phosphorothioate (PS) bonds

<400>  300
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  400
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  400
guuuuagagc uaugcuguuu ug                                                22


<210>  401
<211>  80
<212>  RNA
<213>  Homo sapiens

<400>  401
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu                                                   80


<210>  402
<211>  76
<212>  RNA
<213>  Homo sapiens

<400>  402
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugc                                                       76


<210>  500
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  500

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Arg Lys Thr Gly Gly Tyr Ser Asn Gln Pro Gln His Phe Gly Asp 
        115                 120                 125             


Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn 
305                 310                 315                 320 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                325                 330                 335     


Met Glu Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu 
            340                 345                 350         


Thr Trp Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile 
        355                 360                 365             


Leu Arg Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala 
    370                 375                 380                 


Leu Tyr Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val 
385                 390                 395                 400 


Phe Leu Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys 
                405                 410                 415     


Ile Ser Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu 
            420                 425                 430         


Thr Ala Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Ala 
        435                 440                 445             


Trp Ile Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
    450                 455                 460                 


Val Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
465                 470                 475                 480 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
                485                 490                 495     


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
            500                 505                 510         


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
        515                 520                 525             


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
    530                 535                 540                 


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
545                 550                 555                 560 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
                565                 570                 575     


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
            580                 585                 590         


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605             


<210>  501
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  501

Met Glu Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu 
1               5                   10                  15      


Thr Trp Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile 
            20                  25                  30          


Leu Arg Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala 
        35                  40                  45              


Leu Tyr Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val 
    50                  55                  60                  


Phe Leu Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys 
65                  70                  75                  80  


Ile Ser Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu 
                85                  90                  95      


Thr Ala Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Ala 
            100                 105                 110         


Trp Ile Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  502
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  502

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Arg Lys Thr Gly Gly Tyr Ser Asn Gln Pro Gln His Phe Gly Asp 
        115                 120                 125             


Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  503
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  503

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Arg Lys Thr Gly Gly Tyr Ser Asn Gln Pro Gln His Phe Gly Asp 
        115                 120                 125             


Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn 
305                 310                 315                 320 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                325                 330                 335     


Met Glu Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu 
            340                 345                 350         


Thr Trp Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile 
        355                 360                 365             


Leu Arg Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala 
    370                 375                 380                 


Leu Tyr Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val 
385                 390                 395                 400 


Phe Leu Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys 
                405                 410                 415     


Ile Ser Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu 
            420                 425                 430         


Thr Ala Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Ala 
        435                 440                 445             


Trp Ile Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
    450                 455                 460                 


Val Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
465                 470                 475                 480 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
                485                 490                 495     


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
            500                 505                 510         


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
        515                 520                 525             


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
    530                 535                 540                 


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
545                 550                 555                 560 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
                565                 570                 575     


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
            580                 585                 590         


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605             


<210>  504
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  504

Met Glu Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu 
1               5                   10                  15      


Thr Trp Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile 
            20                  25                  30          


Leu Arg Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala 
        35                  40                  45              


Leu Tyr Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val 
    50                  55                  60                  


Phe Leu Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys 
65                  70                  75                  80  


Ile Ser Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu 
                85                  90                  95      


Thr Ala Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Ala 
            100                 105                 110         


Trp Ile Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  505
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  505

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Arg Lys Thr Gly Gly Tyr Ser Asn Gln Pro Gln His Phe Gly Asp 
        115                 120                 125             


Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  506
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Pro Gly Ala Leu Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
305                 310                 315                 320 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Thr Ser Ile 
                325                 330                 335     


Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp Leu Val Asn Gly 
            340                 345                 350         


Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val Gln Glu Gly Asp 
        355                 360                 365             


Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala Ser Asn Tyr Phe 
    370                 375                 380                 


Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln Leu Ile Ile Asp 
385                 390                 395                 400 


Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg Ile Ala Val Thr 
                405                 410                 415     


Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile Thr Glu Thr Gln 
            420                 425                 430         


Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Thr Glu Asp Leu Thr 
        435                 440                 445             


Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro Asp Ile Gln 
    450                 455                 460                 


Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp 
465                 470                 475                 480 


Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser 
                485                 490                 495     


Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp 
            500                 505                 510         


Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn 
        515                 520                 525             


Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro 
    530                 535                 540                 


Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu 
545                 550                 555                 560 


Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu 
                565                 570                 575     


Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            580                 585                 590         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600         


<210>  507
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  507

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Thr 
            100                 105                 110         


Glu Asp Leu Thr Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys 
        115                 120                 125             


Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  508
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  508

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Pro Gly Ala Leu Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  509
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  509

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Glu Leu Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His 
            20                  25                  30          


Leu Val Met Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His 
        35                  40                  45              


Leu Gly His Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro 
    50                  55                  60                  


Leu Glu Leu Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn 
65                  70                  75                  80  


Ser Val Pro Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu 
                85                  90                  95      


Phe Leu His Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu 
            100                 105                 110         


Cys Ala Ser Ser Gln Asp Tyr Leu Val Ser Asn Glu Lys Leu Phe Phe 
        115                 120                 125             


Gly Ser Gly Thr Gln Leu Ser Val Leu Glu Asp Leu Lys Asn Val Phe 
    130                 135                 140                 


Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His 
145                 150                 155                 160 


Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp 
                165                 170                 175     


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
            180                 185                 190         


Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp 
        195                 200                 205             


Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu 
225                 230                 235                 240 


Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln 
                245                 250                 255     


Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser 
            260                 265                 270         


Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val 
    290                 295                 300                 


Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala 
305                 310                 315                 320 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
                325                 330                 335     


Gly Pro Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln 
            340                 345                 350         


Leu Ser Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly 
        355                 360                 365             


Pro Phe Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr 
    370                 375                 380                 


Ser Asn Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg 
385                 390                 395                 400 


Lys Glu Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp 
                405                 410                 415     


Gly Arg Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu 
            420                 425                 430         


Leu Ile Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val 
        435                 440                 445             


Val Asn Leu Leu Ser Asn Gln Gly Gly Lys Leu Ile Phe Gly Gln Gly 
    450                 455                 460                 


Thr Glu Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val 
465                 470                 475                 480 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
                485                 490                 495     


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
            500                 505                 510         


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
        515                 520                 525             


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
    530                 535                 540                 


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
545                 550                 555                 560 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
                565                 570                 575     


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
            580                 585                 590         


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
        595                 600                 605             


Leu Trp Ser Ser 
    610         


<210>  510
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  510

Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe 
            20                  25                  30          


Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn 
        35                  40                  45              


Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu 
    50                  55                  60                  


Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg 
65                  70                  75                  80  


Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile 
                85                  90                  95      


Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Asn 
            100                 105                 110         


Leu Leu Ser Asn Gln Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu 
        115                 120                 125             


Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  511
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  511

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Glu Leu Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His 
            20                  25                  30          


Leu Val Met Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His 
        35                  40                  45              


Leu Gly His Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro 
    50                  55                  60                  


Leu Glu Leu Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn 
65                  70                  75                  80  


Ser Val Pro Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu 
                85                  90                  95      


Phe Leu His Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu 
            100                 105                 110         


Cys Ala Ser Ser Gln Asp Tyr Leu Val Ser Asn Glu Lys Leu Phe Phe 
        115                 120                 125             


Gly Ser Gly Thr Gln Leu Ser Val Leu Glu Asp Leu Lys Asn Val Phe 
    130                 135                 140                 


Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His 
145                 150                 155                 160 


Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp 
                165                 170                 175     


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
            180                 185                 190         


Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp 
        195                 200                 205             


Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu 
225                 230                 235                 240 


Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln 
                245                 250                 255     


Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser 
            260                 265                 270         


Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val 
    290                 295                 300                 


Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 315     


<210>  512
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  512

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Glu Leu Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His 
            20                  25                  30          


Leu Val Met Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His 
        35                  40                  45              


Leu Gly His Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro 
    50                  55                  60                  


Leu Glu Leu Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn 
65                  70                  75                  80  


Ser Val Pro Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu 
                85                  90                  95      


Phe Leu His Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu 
            100                 105                 110         


Cys Ala Ser Ser Gln Asp Tyr Leu Val Ser Asn Glu Lys Leu Phe Phe 
        115                 120                 125             


Gly Ser Gly Thr Gln Leu Ser Val Leu Glu Asp Leu Lys Asn Val Phe 
    130                 135                 140                 


Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His 
145                 150                 155                 160 


Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp 
                165                 170                 175     


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
            180                 185                 190         


Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp 
        195                 200                 205             


Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu 
225                 230                 235                 240 


Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln 
                245                 250                 255     


Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser 
            260                 265                 270         


Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val 
    290                 295                 300                 


Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala 
305                 310                 315                 320 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
                325                 330                 335     


Gly Pro Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln 
            340                 345                 350         


Leu Ser Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly 
        355                 360                 365             


Pro Phe Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr 
    370                 375                 380                 


Ser Asn Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg 
385                 390                 395                 400 


Lys Glu Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp 
                405                 410                 415     


Gly Arg Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu 
            420                 425                 430         


Leu Ile Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val 
        435                 440                 445             


Val Asn Leu Leu Ser Asn Gln Gly Gly Lys Leu Ile Phe Gly Gln Gly 
    450                 455                 460                 


Thr Glu Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val 
465                 470                 475                 480 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
                485                 490                 495     


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
            500                 505                 510         


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
        515                 520                 525             


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
    530                 535                 540                 


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
545                 550                 555                 560 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
                565                 570                 575     


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
            580                 585                 590         


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
        595                 600                 605             


Leu Trp Ser Ser 
    610         


<210>  513
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  513

Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe 
            20                  25                  30          


Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn 
        35                  40                  45              


Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu 
    50                  55                  60                  


Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg 
65                  70                  75                  80  


Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile 
                85                  90                  95      


Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Asn 
            100                 105                 110         


Leu Leu Ser Asn Gln Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu 
        115                 120                 125             


Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  514
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  514

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Glu Leu Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His 
            20                  25                  30          


Leu Val Met Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His 
        35                  40                  45              


Leu Gly His Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro 
    50                  55                  60                  


Leu Glu Leu Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn 
65                  70                  75                  80  


Ser Val Pro Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu 
                85                  90                  95      


Phe Leu His Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu 
            100                 105                 110         


Cys Ala Ser Ser Gln Asp Tyr Leu Val Ser Asn Glu Lys Leu Phe Phe 
        115                 120                 125             


Gly Ser Gly Thr Gln Leu Ser Val Leu Glu Asp Leu Lys Asn Val Phe 
    130                 135                 140                 


Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His 
145                 150                 155                 160 


Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp 
                165                 170                 175     


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
            180                 185                 190         


Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp 
        195                 200                 205             


Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu 
225                 230                 235                 240 


Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln 
                245                 250                 255     


Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser 
            260                 265                 270         


Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val 
    290                 295                 300                 


Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 315     


<210>  515
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  515

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Arg Gly Gly Leu 
        115                 120                 125             


Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln Leu Ser Val Leu Glu Asp 
    130                 135                 140                 


Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu 
145                 150                 155                 160 


Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr 
                165                 170                 175     


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
            180                 185                 190         


Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln 
        195                 200                 205             


Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val 
    210                 215                 220                 


Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val 
225                 230                 235                 240 


Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala 
                245                 250                 255     


Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp 
            260                 265                 270         


Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
        275                 280                 285             


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
    290                 295                 300                 


Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Gly 
305                 310                 315                 320 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                325                 330                 335     


Glu Asn Pro Gly Pro Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr 
            340                 345                 350         


Ala Ser Leu Trp Leu Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr 
        355                 360                 365             


Gln Pro Gly Met Phe Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys 
    370                 375                 380                 


Thr Tyr Asp Thr Ser Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln 
385                 390                 395                 400 


Pro Ser Ser Gly Glu Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp 
                405                 410                 415     


Gln Gln Asn Ala Thr Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala 
            420                 425                 430         


Arg Lys Ser Ala Asn Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser 
        435                 440                 445             


Ala Met Tyr Phe Cys Ala Ile Ser Gly Asn Thr Pro Leu Val Phe Gly 
    450                 455                 460                 


Lys Gly Thr Arg Leu Ser Val Ile Ala Asn Ile Gln Asn Pro Asp Pro 
465                 470                 475                 480 


Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys 
                485                 490                 495     


Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp 
            500                 505                 510         


Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met 
        515                 520                 525             


Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe 
    530                 535                 540                 


Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe 
545                 550                 555                 560 


Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser 
                565                 570                 575     


Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly 
            580                 585                 590         


Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
        595                 600                 605             


Leu Arg Leu Trp Ser Ser 
    610                 


<210>  516
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  516

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Ile Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu 
        115                 120                 125             


Ser Val Ile Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  517
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  517

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Arg Gly Gly Leu 
        115                 120                 125             


Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln Leu Ser Val Leu Glu Asp 
    130                 135                 140                 


Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu 
145                 150                 155                 160 


Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr 
                165                 170                 175     


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
            180                 185                 190         


Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln 
        195                 200                 205             


Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val 
    210                 215                 220                 


Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val 
225                 230                 235                 240 


Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala 
                245                 250                 255     


Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp 
            260                 265                 270         


Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
        275                 280                 285             


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
    290                 295                 300                 


Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
305                 310                 315                 


<210>  518
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  518

Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Tyr Arg Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
305                 310                 315                 320 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Met Leu 
                325                 330                 335     


Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro Asp Trp Val Asn 
            340                 345                 350         


Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln Asn Ser Pro Ser 
        355                 360                 365             


Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn Cys Asp Tyr Thr 
    370                 375                 380                 


Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys Tyr Pro Ala Glu 
385                 390                 395                 400 


Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys Asp Lys Asn Glu 
                405                 410                 415     


Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala Lys His Leu Ser 
            420                 425                 430         


Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys 
        435                 440                 445             


Ala Ala Arg Gly Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu 
    450                 455                 460                 


Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
465                 470                 475                 480 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
                485                 490                 495     


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
            500                 505                 510         


Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
        515                 520                 525             


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
    530                 535                 540                 


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
545                 550                 555                 560 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
                565                 570                 575     


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
            580                 585                 590         


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
        595                 600                 605             


Ser 
    


<210>  519
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  519

Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro 
1               5                   10                  15      


Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln 
            20                  25                  30          


Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn 
        35                  40                  45              


Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys 
    50                  55                  60                  


Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys 
65                  70                  75                  80  


Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala 
                85                  90                  95      


Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Arg Gly Gln Gly Asn Leu Ile Phe Gly Lys 
        115                 120                 125             


Gly Thr Lys Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  520
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  520

Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Tyr Arg Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  521
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  521

Met Ser Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Arg Gly Tyr His Arg Leu Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ile 
                325                 330                 335     


Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser Trp Val 
            340                 345                 350         


Trp Ser Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Ser Gly Gly Ser Ala Trp Ser His Pro Gln Phe 
    370                 375                 380                 


Glu Lys Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn Val 
385                 390                 395                 400 


Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser Ala 
                405                 410                 415     


Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro Lys 
            420                 425                 430         


Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe Thr 
        435                 440                 445             


Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg Asp 
    450                 455                 460                 


Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Lys Pro Asp 
465                 470                 475                 480 


Pro Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu 
                485                 490                 495     


Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
            500                 505                 510         


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
        515                 520                 525             


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
    530                 535                 540                 


Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
545                 550                 555                 560 


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
                565                 570                 575     


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
            580                 585                 590         


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
        595                 600                 605             


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
    610                 615                 620                 


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
625                 630                 635                 640 


Ser 
    


<210>  522
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  522

Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Ala Trp Ser His Pro 
        35                  40                  45              


Gln Phe Glu Lys Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe 
    50                  55                  60                  


Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn 
65                  70                  75                  80  


Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu 
                85                  90                  95      


Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg 
            100                 105                 110         


Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile 
        115                 120                 125             


Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Lys 
    130                 135                 140                 


Pro Asp Pro Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr 
145                 150                 155                 160 


Lys Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
                165                 170                 175     


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
            180                 185                 190         


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
        195                 200                 205             


Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys 
    210                 215                 220                 


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
225                 230                 235                 240 


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
                245                 250                 255     


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
            260                 265                 270         


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
        275                 280                 285             


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
    290                 295                 300                 


Trp Ser Ser 
305         


<210>  523
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  523

Met Ser Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Arg Gly Tyr His Arg Leu Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Ser Arg Gly 
305                 310         


<210>  600
<211>  7
<212>  PRT
<213>  SV40

<400>  600

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  601
<211>  7
<212>  PRT
<213>  SV40

<400>  601

Pro Lys Lys Lys Arg Arg Val 
1               5           


<210>  602
<211>  16
<212>  PRT
<213>  Xenopus laevis

<400>  602

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  603
<211>  1183
<212>  DNA
<213>  Homo sapiens

<400>  603
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccacgc ccctggctgc agtacgtgat tcttgatccc gagcttcggg ttggaagtgg      360

gtgggagagt tcgaggcctt gcgcttaagg agccccttcg cctcgtgctt gagttgaggc      420

ctggcttggg cgctggggcc gccgcgtgcg aatctggtgg caccttcgcg cctgtctcgc      480

tgctttcgat aagtctctag ccatttaaaa tttttgatga cctgctgcga cgcttttttt      540

ctggcaagat agtcttgtaa atgcgggcca agatgtgcac actggtattt cggtttttgg      600

ggccgcgggc ggcgacgggg cccgtgcgtc ccagcgcaca tgttcggcga ggcggggcct      660

gcgagcgcgg ccaccgagaa tcggacgggg gtagtctcaa gctggccggc ctgctctggt      720

gcctggcctc gcgccgccgt gtatcgcccc gccctgggcg gcaaggctgg cccggtcggc      780

accagttgcg tgagcggaaa gatggccgct tcccggccct gctgcaggga gctcaaaatg      840

gaggacgcgg cgctcgggag agcgggcggg tgagtcaccc acacaaagga aaagggcctt      900

tccgtcctca gccgtcgctt catgtgactc cacggagtac cgggcgccgt ccaggcacct      960

cgattagttc tcgagctttt ggagtacgtc gtctttaggt tggggggagg ggttttatgc     1020

gatggagttt ccccacactg agtgggtgga gactgaagtt aggccagctt ggcacttgat     1080

gtaattctcc ttggaatttg ccctttttga gtttggatct tggttcattc tcaagcctca     1140

gacagtggtt caaagttttt ttcttccatt tcaggtgtcg tga                       1183


<210>  604
<211>  238
<212>  DNA
<213>  Homo sapiens

<400>  604
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggt        238


<210>  605
<211>  457
<212>  DNA
<213>  Homo sapiens

<400>  605
aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc       60

ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat atctgtggta      120

agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg gtcccgccct      180

cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct gaaatgaccc      240

tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg cgcttctgct      300

ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca      360

tccacgctgt tttgacctcc atagaagaca ccgactctag aggatcgatc ccccgggctg      420

caggaattca agcgagaaga caagggcaga aagcacc                               457


<210>  606
<211>  426
<212>  DNA
<213>  Homo sapiens

<400>  606
gatccgaaca gagagacagc agaatatggg ccaaacagga tatctgtggt aagcagttcc       60

tgccccggct cagggccaag aacagttgga acagcagaat atgggccaaa caggatatct      120

gtggtaagca gttcctgccc cggctcaggg ccaagaacag atggtcccca gatgcggtcc      180

cgccctcagc agtttctaga gaaccatcag atgtttccag ggtgccccaa ggacctgaaa      240

tgaccctgtg ccttatttga actaaccaat cagttcgctt ctcgcttctg ttcgcgcgct      300

tctgctcccc gagctctata taagcagagc tcgtttagtg aaccgtcaga tcgcctggag      360

acgccatcca cgctgttttg acctccatag aagacaccga ctctagagga tccaccggtc      420

gccacc                                                                 426


<210>  607
<211>  500
<212>  DNA
<213>  Homo sapiens

<400>  607
gggtagggga ggcgcttttc ccaaggcagt ctggagcatg cgctttagca gccccgctgg       60

gcacttggcg ctacacaagt ggcctctggc ctcgcacaca ttccacatcc accggtaggc      120

gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct cccctagtca      180

ggaagttccc ccccgccccg cagctcgcgt cgtgcaggac gtgacaaatg gaagtagcac      240

gtctcactag tctcgtgcag atggacagca ccgctgagca atggaagcgg gtaggccttt      300

ggggcagcgg ccaatagcag ctttgctcct tcgctttctg ggctcagagg ctgggaaggg      360

gtgggtccgg gggcgggctc aggggcgggc tcaggggcgg ggcgggcgcc cgaaggtcct      420

ccggaggccc ggcattctgc acgcttcaaa agcgcacgtc tgccgcgctg ttctcctctt      480

cctcatctcc gggcctttcg                                                  500


<210>  608
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  608
gagggccgcg gcagcctgct gacctgcggc gacgtggagg agaatcccgg cccc             54


<210>  609
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving peptide derived from porcine teschovirus-1

<400>  609

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  610
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enhanced Green Fluorescent Protein

<400>  610

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Met 
225                 230                 235                 240 


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
                245                 250                 255     


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            260                 265                 270         


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        275                 280                 285             


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    290                 295                 300                 


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
305                 310                 315                 320 


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                325                 330                 335     


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            340                 345                 350         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        355                 360                 365             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    370                 375                 380                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
385                 390                 395                 400 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                405                 410                 415     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            420                 425                 430         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        435                 440                 445             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    450                 455                 460                 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
465                 470                 475             


<210>  611
<211>  35
<212>  DNA
<213>  SV40

<400>  611
aataaagcaa tagcatcaca aatttcacaa ataaa                                  35


<210>  612
<211>  276
<212>  DNA
<213>  Homo sapiens

<400>  612
cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct       60

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc      120

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg      180

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg gcttctgagg      240

cggaaagaac cagctggggc tctagggggt atcccc                                276


<210>  613
<211>  4612
<212>  DNA
<213>  Homo sapiens

<400>  613
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc taatgtgata gatttcccaa cttaatgcca      180

acataccata aacctcccat tctgctaatg cccagcctaa gttggggaga ccactccaga      240

ttccaagatg tacagtttgc tttgctgggc ctttttccca tgcctgcctt tactctgcca      300

gagttatatt gctggggttt tgaagaagat cctattaaat aaaagaataa gcagtattat      360

taagtagccc tgcatttcag gtttccttga gtggcaggcc aggcctggcc gtgaacgttc      420

actgaaatca tggcctcttg gccaagattg atagcttgtg cctgtccctg agtcccagtc      480

catcacgagc agctggtttc taagatgcta tttcccgtat aaagcatgag accgtgactt      540

gccagcccca cagagccccg cccttgtcca tcactggcat ctggactcca gcctgggttg      600

gggcaaagag ggaaatgaga tcatgtccta accctgatcc tcttgtccca cggctccggt      660

gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc      720

ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg      780

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc      840

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt      900

tcccgcgggc ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg      960

cccctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag     1020

ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcttgg     1080

gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga     1140

taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga     1200

tagtcttgta aatgcgggcc aagatgtgca cactggtatt tcggtttttg gggccgcggg     1260

cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg     1320

gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct     1380

cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc     1440

gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg     1500

gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc     1560

agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt     1620

ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt     1680

tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc     1740

cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt     1800

tcaaagtttt tttcttccat ttcaggtgtc gtgacggccg gccccgccac catgagcaat     1860

caagtccttt gttgtgttgt cctgtgtttc cttggcgcaa ataccgtcga cggcgggata     1920

actcagtccc ccaaatacct cttcagaaaa gaaggacaaa acgtaacgct ttcctgcgag     1980

cagaatctta accacgacgc catgtactgg tacaggcaag accctggaca aggtcttagg     2040

ctcatatact actctcagat tgtcaatgac ttccaaaaag gggacatagc tgagggctac     2100

tctgtgtccc gagagaagaa ggagtcattt cccctgacag tgacttctgc acaaaaaaat     2160

cccactgcat tttatttgtg tgccagttca ccgggtgcat tgtatgagca atactttggc     2220

cccggcacta gactgacagt tacggaggat ctgaaaaacg tcttcccgcc agaggtggca     2280

gttttcgagc ccagtgaggc tgaaatctct catacccaaa aagcaaccct tgtctgtctc     2340

gccactggat tctatcccga ccacgtcgaa ttgagctggt gggtcaatgg gaaagaggta     2400

catagtgggg tctgtacgga tccacaaccc cttaaggaac aacctgccct taacgattca     2460

cgatactgcc tgtcatcacg actcagggta tctgctacct tttggcagaa cccgagaaat     2520

cactttcggt gccaggttca gttttacgga cttagcgaaa atgatgaatg gacacaagac     2580

cgagcaaagc ccgttactca aatagtgagc gcggaagcct gggggcgagc agactgcggc     2640

ttcacctccg aaagttacca gcaaggtgtt ttgtcagcca ccattttgta tgagattttg     2700

ttggggaagg cgacacttta cgcggtactg gtctctgcct tggttcttat ggctatggtc     2760

aagaggaaag attccagggg tggctccggt gccacaaact tctccctgct caagcaggcc     2820

ggagatgtgg aagagaaccc tggccctatg acctctatca gagctgtctt tatatttctc     2880

tggcttcaac ttgatctggt gaatggcgaa aacgtggaac agcacccttc aacgttgagc     2940

gttcaggaag gagattcagc cgtcatcaag tgtacgtatt ccgattccgc gtcaaactac     3000

ttcccgtggt acaaacagga acttggcaag cgcccccagc tcattatcga catcagaagc     3060

aacgtaggag agaagaagga ccaacgcata gctgtgactc tcaacaaaac agctaaacat     3120

ttctccctgc acattacgga aacccaacca gaggattctg ccgtatactt ttgtgctgct     3180

actgaggacc tcactttgat ctggggagcg ggtacgaagc tcataataaa acccgatatc     3240

caaaacccgg acccagcagt ttatcaattg agagatagta agtccagtga caaatcagtt     3300

tgtttgttta cggatttcga tagccagacc aatgtcagtc agtcaaagga cagtgatgta     3360

tacattacag ataaatgtgt acttgacatg cgctcaatgg actttaagtc taactctgct     3420

gtagcttggt ctaacaaaag tgattttgcg tgtgccaacg catttaacaa cagcatcata     3480

cctgaagaca cgttctttcc gagtccagaa agttcctgtg acgtgaaact tgtagaaaag     3540

agtttcgaga ccgacactaa ccttaacttt caaaaccttt cagtgatcgg atttagaatc     3600

ttgctgctca aggtggcagg gttcaatctg ctgatgactc tgcgactgtg gagttcataa     3660

cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     3720

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     3780

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     3840

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg gcttctgagg     3900

cggaaagaac cagctggggc tctagggggt atccccacca gctgagagac tctaaatcca     3960

gtgacaagtc tgtctgccta ttcaccgatt ttgattctca aacaaatgtg tcacaaagta     4020

aggattctga tgtgtatatc acagacaaaa ctgtgctaga catgaggtct atggacttca     4080

agagcaacag tgctgtggcc tggagcaaca aatctgactt tgcatgtgca aacgccttca     4140

acaacagcat tattccagaa gacaccttct tccccagccc aggtaagggc agctttggtg     4200

ccttcgcagg ctgtttcctt gcttcaggaa tggccaggtt ctgcccagag ctctggtcaa     4260

tgatgtctaa aactcctctg attggtggtc tcggccttat ccattgccac caaaaccctc     4320

tttttactaa gaaacagtga gccttgttct ggcagtccag agaatgacac gggaaaaaag     4380

cagatgaaga gaaggtggca ggagagggca cgtggcccag cctcagtctc tccaacagat     4440

ctaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     4500

ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt cgcccggcct cagtgagcga     4560

gcgagcgcgc agagagggag tggccaaacg cgtggtgtaa tcatggtcat ag             4612


<210>  614
<211>  3618
<212>  DNA
<213>  Homo sapiens

<400>  614
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc taatgtgata gatttcccaa cttaatgcca      180

acataccata aacctcccat tctgctaatg cccagcctaa gttggggaga ccactccaga      240

ttccaagatg tacagtttgc tttgctgggc ctttttccca tgcctgcctt tactctgcca      300

gagttatatt gctggggttt tgaagaagat cctattaaat aaaagaataa gcagtattat      360

taagtagccc tgcatttcag gtttccttga gtggcaggcc aggcctggcc gtgaacgttc      420

actgaaatca tggcctcttg gccaagattg atagcttgtg cctgtccctg agtcccagtc      480

catcacgagc agctggtttc taagatgcta tttcccgtat aaagcatgag accgtgactt      540

gccagcccca cagagccccg cccttgtcca tcactggcat ctggactcca gcctgggttg      600

gggcaaagag ggaaatgaga tcatgtccta accctgatcc tcttgtccca ccgtgaggct      660

ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag      720

gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg      780

tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag      840

tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacaggtc gcaccatgag      900

caatcaagtc ctttgttgtg ttgtcctgtg tttccttggc gcaaataccg tcgacggcgg      960

gataactcag tcccccaaat acctcttcag aaaagaagga caaaacgtaa cgctttcctg     1020

cgagcagaat cttaaccacg acgccatgta ctggtacagg caagaccctg gacaaggtct     1080

taggctcata tactactctc agattgtcaa tgacttccaa aaaggggaca tagctgaggg     1140

ctactctgtg tcccgagaga agaaggagtc atttcccctg acagtgactt ctgcacaaaa     1200

aaatcccact gcattttatt tgtgtgccag ttcaccgggt gcattgtatg agcaatactt     1260

tggccccggc actagactga cagttacgga ggatctgaaa aacgtcttcc cgccagaggt     1320

ggcagttttc gagcccagtg aggctgaaat ctctcatacc caaaaagcaa cccttgtctg     1380

tctcgccact ggattctatc ccgaccacgt cgaattgagc tggtgggtca atgggaaaga     1440

ggtacatagt ggggtctgta cggatccaca accccttaag gaacaacctg cccttaacga     1500

ttcacgatac tgcctgtcat cacgactcag ggtatctgct accttttggc agaacccgag     1560

aaatcacttt cggtgccagg ttcagtttta cggacttagc gaaaatgatg aatggacaca     1620

agaccgagca aagcccgtta ctcaaatagt gagcgcggaa gcctgggggc gagcagactg     1680

cggcttcacc tccgaaagtt accagcaagg tgttttgtca gccaccattt tgtatgagat     1740

tttgttgggg aaggcgacac tttacgcggt actggtctct gccttggttc ttatggctat     1800

ggtcaagagg aaagattcca ggggtggctc cggtgccaca aacttctccc tgctcaagca     1860

ggccggagat gtggaagaga accctggccc tatgacctct atcagagctg tctttatatt     1920

tctctggctt caacttgatc tggtgaatgg cgaaaacgtg gaacagcacc cttcaacgtt     1980

gagcgttcag gaaggagatt cagccgtcat caagtgtacg tattccgatt ccgcgtcaaa     2040

ctacttcccg tggtacaaac aggaacttgg caagcgcccc cagctcatta tcgacatcag     2100

aagcaacgta ggagagaaga aggaccaacg catagctgtg actctcaaca aaacagctaa     2160

acatttctcc ctgcacatta cggaaaccca accagaggat tctgccgtat acttttgtgc     2220

tgctactgag gacctcactt tgatctgggg agcgggtacg aagctcataa taaaacccga     2280

tatccaaaac ccggacccag cagtttatca attgagagat agtaagtcca gtgacaaatc     2340

agtttgtttg tttacggatt tcgatagcca gaccaatgtc agtcagtcaa aggacagtga     2400

tgtatacatt acagataaat gtgtacttga catgcgctca atggacttta agtctaactc     2460

tgctgtagct tggtctaaca aaagtgattt tgcgtgtgcc aacgcattta acaacagcat     2520

catacctgaa gacacgttct ttccgagtcc agaaagttcc tgtgacgtga aacttgtaga     2580

aaagagtttc gagaccgaca ctaaccttaa ctttcaaaac ctttcagtga tcggatttag     2640

aatcttgctg ctcaaggtgg cagggttcaa tctgctgatg actctgcgac tgtggagttc     2700

ataacctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct     2760

tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca     2820

tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag     2880

ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct     2940

gaggcggaaa gaaccagctg gggctctagg gggtatcccc accagctgag agactctaaa     3000

tccagtgaca agtctgtctg cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa     3060

agtaaggatt ctgatgtgta tatcacagac aaaactgtgc tagacatgag gtctatggac     3120

ttcaagagca acagtgctgt ggcctggagc aacaaatctg actttgcatg tgcaaacgcc     3180

ttcaacaaca gcattattcc agaagacacc ttcttcccca gcccaggtaa gggcagcttt     3240

ggtgccttcg caggctgttt ccttgcttca ggaatggcca ggttctgccc agagctctgg     3300

tcaatgatgt ctaaaactcc tctgattggt ggtctcggcc ttatccattg ccaccaaaac     3360

cctcttttta ctaagaaaca gtgagccttg ttctggcagt ccagagaatg acacgggaaa     3420

aaagcagatg aagagaaggt ggcaggagag ggcacgtggc ccagcctcag tctctccaac     3480

agatctagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     3540

ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga     3600

gcgagcgagc gcgcagag                                                   3618


<210>  615
<211>  3825
<212>  DNA
<213>  Homo sapiens

<400>  615
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tagatctaat gtgatagatt tcccaactta atgccaacat      180

accataaacc tcccattctg ctaatgccca gcctaagttg gggagaccac tccagattcc      240

aagatgtaca gtttgctttg ctgggccttt ttcccatgcc tgcctttact ctgccagagt      300

tatattgctg gggttttgaa gaagatccta ttaaataaaa gaataagcag tattattaag      360

tagccctgca tttcaggttt ccttgagtgg caggccaggc ctggccgtga acgttcactg      420

aaatcatggc ctcttggcca agattgatag cttgtgcctg tccctgagtc ccagtccatc      480

acgagcagct ggtttctaag atgctatttc ccgtataaag catgagaccg tgacttgcca      540

gccccacaga gccccgccct tgtccatcac tggcatctgg actccagcct gggttggggc      600

aaagagggaa atgagatcat gtcctaaccc tgatcctctt gtcccacaac agagaaacag      660

gagaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa      720

gaacagttgg aacagcagaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc      780

ccggctcagg gccaagaaca gatggtcccc agatgcggtc ccgccctcag cagtttctag      840

agaaccatca gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg      900

aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctctat      960

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt     1020

gacctccata gaagacaccg actctagagg atcgatcccc cgggctgcag gaattcaagc     1080

gagaagacaa gggcagaaag caccatgagc aatcaagtcc tttgttgtgt tgtcctgtgt     1140

ttccttggcg caaataccgt cgacggcggg ataactcagt cccccaaata cctcttcaga     1200

aaagaaggac aaaacgtaac gctttcctgc gagcagaatc ttaaccacga cgccatgtac     1260

tggtacaggc aagaccctgg acaaggtctt aggctcatat actactctca gattgtcaat     1320

gacttccaaa aaggggacat agctgagggc tactctgtgt cccgagagaa gaaggagtca     1380

tttcccctga cagtgacttc tgcacaaaaa aatcccactg cattttattt gtgtgccagt     1440

tcaccgggtg cattgtatga gcaatacttt ggccccggca ctagactgac agttacggag     1500

gatctgaaaa acgtcttccc gccagaggtg gcagttttcg agcccagtga ggctgaaatc     1560

tctcataccc aaaaagcaac ccttgtctgt ctcgccactg gattctatcc cgaccacgtc     1620

gaattgagct ggtgggtcaa tgggaaagag gtacatagtg gggtctgtac ggatccacaa     1680

ccccttaagg aacaacctgc ccttaacgat tcacgatact gcctgtcatc acgactcagg     1740

gtatctgcta ccttttggca gaacccgaga aatcactttc ggtgccaggt tcagttttac     1800

ggacttagcg aaaatgatga atggacacaa gaccgagcaa agcccgttac tcaaatagtg     1860

agcgcggaag cctgggggcg agcagactgc ggcttcacct ccgaaagtta ccagcaaggt     1920

gttttgtcag ccaccatttt gtatgagatt ttgttgggga aggcgacact ttacgcggta     1980

ctggtctctg ccttggttct tatggctatg gtcaagagga aagattccag gggtggctcc     2040

ggtgccacaa acttctccct gctcaagcag gccggagatg tggaagagaa ccctggccct     2100

atgacctcta tcagagctgt ctttatattt ctctggcttc aacttgatct ggtgaatggc     2160

gaaaacgtgg aacagcaccc ttcaacgttg agcgttcagg aaggagattc agccgtcatc     2220

aagtgtacgt attccgattc cgcgtcaaac tacttcccgt ggtacaaaca ggaacttggc     2280

aagcgccccc agctcattat cgacatcaga agcaacgtag gagagaagaa ggaccaacgc     2340

atagctgtga ctctcaacaa aacagctaaa catttctccc tgcacattac ggaaacccaa     2400

ccagaggatt ctgccgtata cttttgtgct gctactgagg acctcacttt gatctgggga     2460

gcgggtacga agctcataat aaaacccgat atccaaaacc cggacccagc agtttatcaa     2520

ttgagagata gtaagtccag tgacaaatca gtttgtttgt ttacggattt cgatagccag     2580

accaatgtca gtcagtcaaa ggacagtgat gtatacatta cagataaatg tgtacttgac     2640

atgcgctcaa tggactttaa gtctaactct gctgtagctt ggtctaacaa aagtgatttt     2700

gcgtgtgcca acgcatttaa caacagcatc atacctgaag acacgttctt tccgagtcca     2760

gaaagttcct gtgacgtgaa acttgtagaa aagagtttcg agaccgacac taaccttaac     2820

tttcaaaacc tttcagtgat cggatttaga atcttgctgc tcaaggtggc agggttcaat     2880

ctgctgatga ctctgcgact gtggagttca taacctcgac tgtgccttct agttgccagc     2940

catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg     3000

tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc     3060

tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg     3120

ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg     3180

ggtatcccca ccagctgaga gactctaaat ccagtgacaa gtctgtctgc ctattcaccg     3240

attttgattc tcaaacaaat gtgtcacaaa gtaaggattc tgatgtgtat atcacagaca     3300

aaactgtgct agacatgagg tctatggact tcaagagcaa cagtgctgtg gcctggagca     3360

acaaatctga ctttgcatgt gcaaacgcct tcaacaacag cattattcca gaagacacct     3420

tcttccccag cccaggtaag ggcagctttg gtgccttcgc aggctgtttc cttgcttcag     3480

gaatggccag gttctgccca gagctctggt caatgatgtc taaaactcct ctgattggtg     3540

gtctcggcct tatccattgc caccaaaacc ctctttttac taagaaacag tgagccttgt     3600

tctggcagtc cagagaatga cacgggaaaa aagcagatga agagaaggtg gcaggagagg     3660

gcacgtggcc cagcctcagt ctctccaaca gatctaggaa cccctagtga tggagttggc     3720

cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg     3780

cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct gcagg                     3825


<210>  616
<211>  3794
<212>  DNA
<213>  Homo sapiens

<400>  616
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tagatctaat gtgatagatt tcccaactta atgccaacat      180

accataaacc tcccattctg ctaatgccca gcctaagttg gggagaccac tccagattcc      240

aagatgtaca gtttgctttg ctgggccttt ttcccatgcc tgcctttact ctgccagagt      300

tatattgctg gggttttgaa gaagatccta ttaaataaaa gaataagcag tattattaag      360

tagccctgca tttcaggttt ccttgagtgg caggccaggc ctggccgtga acgttcactg      420

aaatcatggc ctcttggcca agattgatag cttgtgcctg tccctgagtc ccagtccatc      480

acgagcagct ggtttctaag atgctatttc ccgtataaag catgagaccg tgacttgcca      540

gccccacaga gccccgccct tgtccatcac tggcatctgg actccagcct gggttggggc      600

aaagagggaa atgagatcat gtcctaaccc tgatcctctt gtcccacgat ccgaacagag      660

agacagcaga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag      720

ggccaagaac agttggaaca gcagaatatg ggccaaacag gatatctgtg gtaagcagtt      780

cctgccccgg ctcagggcca agaacagatg gtccccagat gcggtcccgc cctcagcagt      840

ttctagagaa ccatcagatg tttccagggt gccccaagga cctgaaatga ccctgtgcct      900

tatttgaact aaccaatcag ttcgcttctc gcttctgttc gcgcgcttct gctccccgag      960

ctctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg ccatccacgc     1020

tgttttgacc tccatagaag acaccgactc tagaggatcc accggtcgcc accatgagca     1080

atcaagtcct ttgttgtgtt gtcctgtgtt tccttggcgc aaataccgtc gacggcggga     1140

taactcagtc ccccaaatac ctcttcagaa aagaaggaca aaacgtaacg ctttcctgcg     1200

agcagaatct taaccacgac gccatgtact ggtacaggca agaccctgga caaggtctta     1260

ggctcatata ctactctcag attgtcaatg acttccaaaa aggggacata gctgagggct     1320

actctgtgtc ccgagagaag aaggagtcat ttcccctgac agtgacttct gcacaaaaaa     1380

atcccactgc attttatttg tgtgccagtt caccgggtgc attgtatgag caatactttg     1440

gccccggcac tagactgaca gttacggagg atctgaaaaa cgtcttcccg ccagaggtgg     1500

cagttttcga gcccagtgag gctgaaatct ctcataccca aaaagcaacc cttgtctgtc     1560

tcgccactgg attctatccc gaccacgtcg aattgagctg gtgggtcaat gggaaagagg     1620

tacatagtgg ggtctgtacg gatccacaac cccttaagga acaacctgcc cttaacgatt     1680

cacgatactg cctgtcatca cgactcaggg tatctgctac cttttggcag aacccgagaa     1740

atcactttcg gtgccaggtt cagttttacg gacttagcga aaatgatgaa tggacacaag     1800

accgagcaaa gcccgttact caaatagtga gcgcggaagc ctgggggcga gcagactgcg     1860

gcttcacctc cgaaagttac cagcaaggtg ttttgtcagc caccattttg tatgagattt     1920

tgttggggaa ggcgacactt tacgcggtac tggtctctgc cttggttctt atggctatgg     1980

tcaagaggaa agattccagg ggtggctccg gtgccacaaa cttctccctg ctcaagcagg     2040

ccggagatgt ggaagagaac cctggcccta tgacctctat cagagctgtc tttatatttc     2100

tctggcttca acttgatctg gtgaatggcg aaaacgtgga acagcaccct tcaacgttga     2160

gcgttcagga aggagattca gccgtcatca agtgtacgta ttccgattcc gcgtcaaact     2220

acttcccgtg gtacaaacag gaacttggca agcgccccca gctcattatc gacatcagaa     2280

gcaacgtagg agagaagaag gaccaacgca tagctgtgac tctcaacaaa acagctaaac     2340

atttctccct gcacattacg gaaacccaac cagaggattc tgccgtatac ttttgtgctg     2400

ctactgagga cctcactttg atctggggag cgggtacgaa gctcataata aaacccgata     2460

tccaaaaccc ggacccagca gtttatcaat tgagagatag taagtccagt gacaaatcag     2520

tttgtttgtt tacggatttc gatagccaga ccaatgtcag tcagtcaaag gacagtgatg     2580

tatacattac agataaatgt gtacttgaca tgcgctcaat ggactttaag tctaactctg     2640

ctgtagcttg gtctaacaaa agtgattttg cgtgtgccaa cgcatttaac aacagcatca     2700

tacctgaaga cacgttcttt ccgagtccag aaagttcctg tgacgtgaaa cttgtagaaa     2760

agagtttcga gaccgacact aaccttaact ttcaaaacct ttcagtgatc ggatttagaa     2820

tcttgctgct caaggtggca gggttcaatc tgctgatgac tctgcgactg tggagttcat     2880

aacctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     2940

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3000

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3060

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga     3120

ggcggaaaga accagctggg gctctagggg gtatccccac cagctgagag actctaaatc     3180

cagtgacaag tctgtctgcc tattcaccga ttttgattct caaacaaatg tgtcacaaag     3240

taaggattct gatgtgtata tcacagacaa aactgtgcta gacatgaggt ctatggactt     3300

caagagcaac agtgctgtgg cctggagcaa caaatctgac tttgcatgtg caaacgcctt     3360

caacaacagc attattccag aagacacctt cttccccagc ccaggtaagg gcagctttgg     3420

tgccttcgca ggctgtttcc ttgcttcagg aatggccagg ttctgcccag agctctggtc     3480

aatgatgtct aaaactcctc tgattggtgg tctcggcctt atccattgcc accaaaaccc     3540

tctttttact aagaaacagt gagccttgtt ctggcagtcc agagaatgac acgggaaaaa     3600

agcagatgaa gagaaggtgg caggagaggg cacgtggccc agcctcagtc tctccaacag     3660

atctaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     3720

gaggccgggc gaccaaaggt cgcccgacgc ccgggcggcc tcagtgagcg agcgagcgcg     3780

cagctgcctg cagg                                                       3794


<210>  617
<211>  3893
<212>  DNA
<213>  Homo sapiens

<400>  617
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct agatctaatg tgatagattt cccaacttaa tgccaacata ccataaacct      180

cccattctgc taatgcccag cctaagttgg ggagaccact ccagattcca agatgtacag      240

tttgctttgc tgggcctttt tcccatgcct gcctttactc tgccagagtt atattgctgg      300

ggttttgaag aagatcctat taaataaaag aataagcagt attattaagt agccctgcat      360

ttcaggtttc cttgagtggc aggccaggcc tggccgtgaa cgttcactga aatcatggcc      420

tcttggccaa gattgatagc ttgtgcctgt ccctgagtcc cagtccatca cgagcagctg      480

gtttctaaga tgctatttcc cgtataaagc atgagaccgt gacttgccag ccccacagag      540

ccccgccctt gtccatcact ggcatctgga ctccagcctg ggttggggca aagagggaaa      600

tgagatcatg tcctaaccct gatcctcttg tcccacgggt aggggaggcg cttttcccaa      660

ggcagtctgg agcatgcgct ttagcagccc cgctgggcac ttggcgctac acaagtggcc      720

tctggcctcg cacacattcc acatccaccg gtaggcgcca accggctccg ttctttggtg      780

gccccttcgc gccaccttct actcctcccc tagtcaggaa gttccccccc gccccgcagc      840

tcgcgtcgtg caggacgtga caaatggaag tagcacgtct cactagtctc gtgcagatgg      900

acagcaccgc tgagcaatgg aagcgggtag gcctttgggg cagcggccaa tagcagcttt      960

gctccttcgc tttctgggct cagaggctgg gaaggggtgg gtccgggggc gggctcaggg     1020

gcgggctcag gggcggggcg ggcgcccgaa ggtcctccgg aggcccggca ttctgcacgc     1080

ttcaaaagcg cacgtctgcc gcgctgttct cctcttcctc atctccgggc ctttcgcgaa     1140

gcaccatgag caatcaagtc ctttgttgtg ttgtcctgtg tttccttggc gcaaataccg     1200

tcgacggcgg gataactcag tcccccaaat acctcttcag aaaagaagga caaaacgtaa     1260

cgctttcctg cgagcagaat cttaaccacg acgccatgta ctggtacagg caagaccctg     1320

gacaaggtct taggctcata tactactctc agattgtcaa tgacttccaa aaaggggaca     1380

tagctgaggg ctactctgtg tcccgagaga agaaggagtc atttcccctg acagtgactt     1440

ctgcacaaaa aaatcccact gcattttatt tgtgtgccag ttcaccgggt gcattgtatg     1500

agcaatactt tggccccggc actagactga cagttacgga ggatctgaaa aacgtcttcc     1560

cgccagaggt ggcagttttc gagcccagtg aggctgaaat ctctcatacc caaaaagcaa     1620

cccttgtctg tctcgccact ggattctatc ccgaccacgt cgaattgagc tggtgggtca     1680

atgggaaaga ggtacatagt ggggtctgta cggatccaca accccttaag gaacaacctg     1740

cccttaacga ttcacgatac tgcctgtcat cacgactcag ggtatctgct accttttggc     1800

agaacccgag aaatcacttt cggtgccagg ttcagtttta cggacttagc gaaaatgatg     1860

aatggacaca agaccgagca aagcccgtta ctcaaatagt gagcgcggaa gcctgggggc     1920

gagcagactg cggcttcacc tccgaaagtt accagcaagg tgttttgtca gccaccattt     1980

tgtatgagat tttgttgggg aaggcgacac tttacgcggt actggtctct gccttggttc     2040

ttatggctat ggtcaagagg aaagattcca ggggtggctc cggtgccaca aacttctccc     2100

tgctcaagca ggccggagat gtggaagaga accctggccc tatgacctct atcagagctg     2160

tctttatatt tctctggctt caacttgatc tggtgaatgg cgaaaacgtg gaacagcacc     2220

cttcaacgtt gagcgttcag gaaggagatt cagccgtcat caagtgtacg tattccgatt     2280

ccgcgtcaaa ctacttcccg tggtacaaac aggaacttgg caagcgcccc cagctcatta     2340

tcgacatcag aagcaacgta ggagagaaga aggaccaacg catagctgtg actctcaaca     2400

aaacagctaa acatttctcc ctgcacatta cggaaaccca accagaggat tctgccgtat     2460

acttttgtgc tgctactgag gacctcactt tgatctgggg agcgggtacg aagctcataa     2520

taaaacccga tatccaaaac ccggacccag cagtttatca attgagagat agtaagtcca     2580

gtgacaaatc agtttgtttg tttacggatt tcgatagcca gaccaatgtc agtcagtcaa     2640

aggacagtga tgtatacatt acagataaat gtgtacttga catgcgctca atggacttta     2700

agtctaactc tgctgtagct tggtctaaca aaagtgattt tgcgtgtgcc aacgcattta     2760

acaacagcat catacctgaa gacacgttct ttccgagtcc agaaagttcc tgtgacgtga     2820

aacttgtaga aaagagtttc gagaccgaca ctaaccttaa ctttcaaaac ctttcagtga     2880

tcggatttag aatcttgctg ctcaaggtgg cagggttcaa tctgctgatg actctgcgac     2940

tgtggagttc ataacctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc     3000

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     3060

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     3120

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc     3180

tatggcttct gaggcggaaa gaaccagctg gggctctagg gggtatcccc accagctgag     3240

agactctaaa tccagtgaca agtctgtctg cctattcacc gattttgatt ctcaaacaaa     3300

tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac aaaactgtgc tagacatgag     3360

gtctatggac ttcaagagca acagtgctgt ggcctggagc aacaaatctg actttgcatg     3420

tgcaaacgcc ttcaacaaca gcattattcc agaagacacc ttcttcccca gcccaggtaa     3480

gggcagcttt ggtgccttcg caggctgttt ccttgcttca ggaatggcca ggttctgccc     3540

agagctctgg tcaatgatgt ctaaaactcc tctgattggt ggtctcggcc ttatccattg     3600

ccaccaaaac cctcttttta ctaagaaaca gtgagccttg ttctggcagt ccagagaatg     3660

acacgggaaa aaagcagatg aagagaaggt ggcaggagag ggcacgtggc ccagcctcag     3720

tctctccaac agatctagga acccctagtg atggagttgg ccactccctc tctgcgcgct     3780

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg     3840

gcctcagtga gcgagcgagc gcgcagctgc ctgcaggaag cttggtgtaa tca            3893


<210>  618
<211>  3857
<212>  DNA
<213>  Homo sapiens

<400>  618
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc taatgtgata gatttcccaa cttaatgcca      180

acataccata aacctcccat tctgctaatg cccagcctaa gttggggaga ccactccaga      240

ttccaagatg tacagtttgc tttgctgggc ctttttccca tgcctgcctt tactctgcca      300

gagttatatt gctggggttt tgaagaagat cctattaaat aaaagaataa gcagtattat      360

taagtagccc tgcatttcag gtttccttga gtggcaggcc aggcctggcc gtgaacgttc      420

actgaaatca tggcctcttg gccaagattg atagcttgtg cctgtccctg agtcccagtc      480

catcacgagc agctggtttc taagatgcta tttcccgtat aaagcatgag accgtgactt      540

gccagcccca cagagccccg cccttgtcca tcactggcat ctggactcca gcctgggttg      600

gggcaaagag ggaaatgaga tcatgtccta accctgatcc tcttgtccca caacagagaa      660

acaggagaat atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg      720

ccaagaacag ttggaacagc agaatatggg ccaaacagga tatctgtggt aagcagttcc      780

tgccccggct cagggccaag aacagatggt ccccagatgc ggtcccgccc tcagcagttt      840

ctagagaacc atcagatgtt tccagggtgc cccaaggacc tgaaatgacc ctgtgcctta      900

tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct      960

ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagacgcc atccacgctg     1020

ttttgacctc catagaagac accgactcta gaggatcgat cccccgggct gcaggaattc     1080

aagcgagaag acaagggcag aaagcaccat gagcaatcaa gtcctttgtt gtgttgtcct     1140

gtgtttcctt ggcgcaaata ccgtcgacgg cgggataact cagtccccca aatacctctt     1200

cagaaaagaa ggacaaaacg taacgctttc ctgcgagcag aatcttaacc acgacgccat     1260

gtactggtac aggcaagacc ctggacaagg tcttaggctc atatactact ctcagattgt     1320

caatgacttc caaaaagggg acatagctga gggctactct gtgtcccgag agaagaagga     1380

gtcatttccc ctgacagtga cttctgcaca aaaaaatccc actgcatttt atttgtgtgc     1440

cagttcaccg ggtgcattgt atgagcaata ctttggcccc ggcactagac tgacagttac     1500

ggaggatctg aaaaacgtct tcccgccaga ggtggcagtt ttcgagccca gtgaggctga     1560

aatctctcat acccaaaaag caacccttgt ctgtctcgcc actggattct atcccgacca     1620

cgtcgaattg agctggtggg tcaatgggaa agaggtacat agtggggtct gtacggatcc     1680

acaacccctt aaggaacaac ctgcccttaa cgattcacga tactgcctgt catcacgact     1740

cagggtatct gctacctttt ggcagaaccc gagaaatcac tttcggtgcc aggttcagtt     1800

ttacggactt agcgaaaatg atgaatggac acaagaccga gcaaagcccg ttactcaaat     1860

agtgagcgcg gaagcctggg ggcgagcaga ctgcggcttc acctccgaaa gttaccagca     1920

aggtgttttg tcagccacca ttttgtatga gattttgttg gggaaggcga cactttacgc     1980

ggtactggtc tctgccttgg ttcttatggc tatggtcaag aggaaagatt ccaggggtgg     2040

ctccggtgcc acaaacttct ccctgctcaa gcaggccgga gatgtggaag agaaccctgg     2100

ccctatgacc tctatcagag ctgtctttat atttctctgg cttcaacttg atctggtgaa     2160

tggcgaaaac gtggaacagc acccttcaac gttgagcgtt caggaaggag attcagccgt     2220

catcaagtgt acgtattccg attccgcgtc aaactacttc ccgtggtaca aacaggaact     2280

tggcaagcgc ccccagctca ttatcgacat cagaagcaac gtaggagaga agaaggacca     2340

acgcatagct gtgactctca acaaaacagc taaacatttc tccctgcaca ttacggaaac     2400

ccaaccagag gattctgccg tatacttttg tgctgctact gaggacctca ctttgatctg     2460

gggagcgggt acgaagctca taataaaacc cgatatccaa aacccggacc cagcagttta     2520

tcaattgaga gatagtaagt ccagtgacaa atcagtttgt ttgtttacgg atttcgatag     2580

ccagaccaat gtcagtcagt caaaggacag tgatgtatac attacagata aatgtgtact     2640

tgacatgcgc tcaatggact ttaagtctaa ctctgctgta gcttggtcta acaaaagtga     2700

ttttgcgtgt gccaacgcat ttaacaacag catcatacct gaagacacgt tctttccgag     2760

tccagaaagt tcctgtgacg tgaaacttgt agaaaagagt ttcgagaccg acactaacct     2820

taactttcaa aacctttcag tgatcggatt tagaatcttg ctgctcaagg tggcagggtt     2880

caatctgctg atgactctgc gactgtggag ttcataacct cgactgtgcc ttctagttgc     2940

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     3000

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     3060

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     3120

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggctct     3180

agggggtatc cccaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc     3240

accgattttg attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca     3300

gacaaaactg tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg     3360

agcaacaaat ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac     3420

accttcttcc ccagcccagg taagggcagc tttggtgcct tcgcaggctg tttccttgct     3480

tcaggaatgg ccaggttctg cccagagctc tggtcaatga tgtctaaaac tcctctgatt     3540

ggtggtctcg gccttatcca ttgccaccaa aaccctcttt ttactaagaa acagtgagcc     3600

ttgttctggc agtccagaga atgacacggg aaaaaagcag atgaagagaa ggtggcagga     3660

gagggcacgt ggcccagcct cagtctctcc aacagatcta ggaaccccta gtgatggagt     3720

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgcccgggca aagcccgggc     3780

gtcgggcgac ctttggtcgc ccggcctcag tgagcgagcg agcgcgcaga gagggagtgg     3840

ccaaacgcgt ggtgtaa                                                    3857


<210>  619
<211>  3891
<212>  DNA
<213>  Homo sapiens

<400>  619
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc taatgtgata gatttcccaa cttaatgcca      180

acataccata aacctcccat tctgctaatg cccagcctaa gttggggaga ccactccaga      240

ttccaagatg tacagtttgc tttgctgggc ctttttccca tgcctgcctt tactctgcca      300

gagttatatt gctggggttt tgaagaagat cctattaaat aaaagaataa gcagtattat      360

taagtagccc tgcatttcag gtttccttga gtggcaggcc aggcctggcc gtgaacgttc      420

actgaaatca tggcctcttg gccaagattg atagcttgtg cctgtccctg agtcccagtc      480

catcacgagc agctggtttc taagatgcta tttcccgtat aaagcatgag accgtgactt      540

gccagcccca cagagccccg cccttgtcca tcactggcat ctggactcca gcctgggttg      600

gggcaaagag ggaaatgaga tcatgtccta accctgatcc tcttgtccca cgggtagggg      660

aggcgctttt cccaaggcag tctggagcat gcgctttagc agccccgctg ggcacttggc      720

gctacacaag tggcctctgg cctcgcacac attccacatc caccggtagg cgccaaccgg      780

ctccgttctt tggtggcccc ttcgcgccac cttctactcc tcccctagtc aggaagttcc      840

cccccgcccc gcagctcgcg tcgtgcagga cgtgacaaat ggaagtagca cgtctcacta      900

gtctcgtgca gatggacagc accgctgagc aatggaagcg ggtaggcctt tggggcagcg      960

gccaatagca gctttgctcc ttcgctttct gggctcagag gctgggaagg ggtgggtccg     1020

ggggcgggct caggggcggg ctcaggggcg gggcgggcgc ccgaaggtcc tccggaggcc     1080

cggcattctg cacgcttcaa aagcgcacgt ctgccgcgct gttctcctct tcctcatctc     1140

cgggcctttc gcgaagcacc atgagcaatc aagtcctttg ttgtgttgtc ctgtgtttcc     1200

ttggcgcaaa taccgtcgac ggcgggataa ctcagtcccc caaatacctc ttcagaaaag     1260

aaggacaaaa cgtaacgctt tcctgcgagc agaatcttaa ccacgacgcc atgtactggt     1320

acaggcaaga ccctggacaa ggtcttaggc tcatatacta ctctcagatt gtcaatgact     1380

tccaaaaagg ggacatagct gagggctact ctgtgtcccg agagaagaag gagtcatttc     1440

ccctgacagt gacttctgca caaaaaaatc ccactgcatt ttatttgtgt gccagttcac     1500

cgggtgcatt gtatgagcaa tactttggcc ccggcactag actgacagtt acggaggatc     1560

tgaaaaacgt cttcccgcca gaggtggcag ttttcgagcc cagtgaggct gaaatctctc     1620

atacccaaaa agcaaccctt gtctgtctcg ccactggatt ctatcccgac cacgtcgaat     1680

tgagctggtg ggtcaatggg aaagaggtac atagtggggt ctgtacggat ccacaacccc     1740

ttaaggaaca acctgccctt aacgattcac gatactgcct gtcatcacga ctcagggtat     1800

ctgctacctt ttggcagaac ccgagaaatc actttcggtg ccaggttcag ttttacggac     1860

ttagcgaaaa tgatgaatgg acacaagacc gagcaaagcc cgttactcaa atagtgagcg     1920

cggaagcctg ggggcgagca gactgcggct tcacctccga aagttaccag caaggtgttt     1980

tgtcagccac cattttgtat gagattttgt tggggaaggc gacactttac gcggtactgg     2040

tctctgcctt ggttcttatg gctatggtca agaggaaaga ttccaggggt ggctccggtg     2100

ccacaaactt ctccctgctc aagcaggccg gagatgtgga agagaaccct ggccctatga     2160

cctctatcag agctgtcttt atatttctct ggcttcaact tgatctggtg aatggcgaaa     2220

acgtggaaca gcacccttca acgttgagcg ttcaggaagg agattcagcc gtcatcaagt     2280

gtacgtattc cgattccgcg tcaaactact tcccgtggta caaacaggaa cttggcaagc     2340

gcccccagct cattatcgac atcagaagca acgtaggaga gaagaaggac caacgcatag     2400

ctgtgactct caacaaaaca gctaaacatt tctccctgca cattacggaa acccaaccag     2460

aggattctgc cgtatacttt tgtgctgcta ctgaggacct cactttgatc tggggagcgg     2520

gtacgaagct cataataaaa cccgatatcc aaaacccgga cccagcagtt tatcaattga     2580

gagatagtaa gtccagtgac aaatcagttt gtttgtttac ggatttcgat agccagacca     2640

atgtcagtca gtcaaaggac agtgatgtat acattacaga taaatgtgta cttgacatgc     2700

gctcaatgga ctttaagtct aactctgctg tagcttggtc taacaaaagt gattttgcgt     2760

gtgccaacgc atttaacaac agcatcatac ctgaagacac gttctttccg agtccagaaa     2820

gttcctgtga cgtgaaactt gtagaaaaga gtttcgagac cgacactaac cttaactttc     2880

aaaacctttc agtgatcgga tttagaatct tgctgctcaa ggtggcaggg ttcaatctgc     2940

tgatgactct gcgactgtgg agttcataac ctcgactgtg ccttctagtt gccagccatc     3000

tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     3060

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg     3120

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg     3180

ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc agctggggct ctagggggta     3240

tccccaccag ctgagagact ctaaatccag tgacaagtct gtctgcctat tcaccgattt     3300

tgattctcaa acaaatgtgt cacaaagtaa ggattctgat gtgtatatca cagacaaaac     3360

tgtgctagac atgaggtcta tggacttcaa gagcaacagt gctgtggcct ggagcaacaa     3420

atctgacttt gcatgtgcaa acgccttcaa caacagcatt attccagaag acaccttctt     3480

ccccagccca ggtaagggca gctttggtgc cttcgcaggc tgtttccttg cttcaggaat     3540

ggccaggttc tgcccagagc tctggtcaat gatgtctaaa actcctctga ttggtggtct     3600

cggccttatc cattgccacc aaaaccctct ttttactaag aaacagtgag ccttgttctg     3660

gcagtccaga gaatgacacg ggaaaaaagc agatgaagag aaggtggcag gagagggcac     3720

gtggcccagc ctcagtctct ccaacagatc taggaacccc tagtgatgga gttggccact     3780

ccctctctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg     3840

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt g              3891


<210>  620
<211>  3820
<212>  DNA
<213>  Homo sapiens

<400>  620
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc taatgtgata gatttcccaa cttaatgcca      180

acataccata aacctcccat tctgctaatg cccagcctaa gttggggaga ccactccaga      240

ttccaagatg tacagtttgc tttgctgggc ctttttccca tgcctgcctt tactctgcca      300

gagttatatt gctggggttt tgaagaagat cctattaaat aaaagaataa gcagtattat      360

taagtagccc tgcatttcag gtttccttga gtggcaggcc aggcctggcc gtgaacgttc      420

actgaaatca tggcctcttg gccaagattg atagcttgtg cctgtccctg agtcccagtc      480

catcacgagc agctggtttc taagatgcta tttcccgtat aaagcatgag accgtgactt      540

gccagcccca cagagccccg cccttgtcca tcactggcat ctggactcca gcctgggttg      600

gggcaaagag ggaaatgaga tcatgtccta accctgatcc tcttgtccca cgatccgaac      660

agagagacag cagaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc      720

tcagggccaa gaacagttgg aacagcagaa tatgggccaa acaggatatc tgtggtaagc      780

agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc ccgccctcag      840

cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa atgaccctgt      900

gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc      960

cgagctctat ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc     1020

acgctgtttt gacctccata gaagacaccg actctagagg atccaccggt cgccaccatg     1080

agcaatcaag tcctttgttg tgttgtcctg tgtttccttg gcgcaaatac cgtcgacggc     1140

gggataactc agtcccccaa atacctcttc agaaaagaag gacaaaacgt aacgctttcc     1200

tgcgagcaga atcttaacca cgacgccatg tactggtaca ggcaagaccc tggacaaggt     1260

cttaggctca tatactactc tcagattgtc aatgacttcc aaaaagggga catagctgag     1320

ggctactctg tgtcccgaga gaagaaggag tcatttcccc tgacagtgac ttctgcacaa     1380

aaaaatccca ctgcatttta tttgtgtgcc agttcaccgg gtgcattgta tgagcaatac     1440

tttggccccg gcactagact gacagttacg gaggatctga aaaacgtctt cccgccagag     1500

gtggcagttt tcgagcccag tgaggctgaa atctctcata cccaaaaagc aacccttgtc     1560

tgtctcgcca ctggattcta tcccgaccac gtcgaattga gctggtgggt caatgggaaa     1620

gaggtacata gtggggtctg tacggatcca caacccctta aggaacaacc tgcccttaac     1680

gattcacgat actgcctgtc atcacgactc agggtatctg ctaccttttg gcagaacccg     1740

agaaatcact ttcggtgcca ggttcagttt tacggactta gcgaaaatga tgaatggaca     1800

caagaccgag caaagcccgt tactcaaata gtgagcgcgg aagcctgggg gcgagcagac     1860

tgcggcttca cctccgaaag ttaccagcaa ggtgttttgt cagccaccat tttgtatgag     1920

attttgttgg ggaaggcgac actttacgcg gtactggtct ctgccttggt tcttatggct     1980

atggtcaaga ggaaagattc caggggtggc tccggtgcca caaacttctc cctgctcaag     2040

caggccggag atgtggaaga gaaccctggc cctatgacct ctatcagagc tgtctttata     2100

tttctctggc ttcaacttga tctggtgaat ggcgaaaacg tggaacagca cccttcaacg     2160

ttgagcgttc aggaaggaga ttcagccgtc atcaagtgta cgtattccga ttccgcgtca     2220

aactacttcc cgtggtacaa acaggaactt ggcaagcgcc cccagctcat tatcgacatc     2280

agaagcaacg taggagagaa gaaggaccaa cgcatagctg tgactctcaa caaaacagct     2340

aaacatttct ccctgcacat tacggaaacc caaccagagg attctgccgt atacttttgt     2400

gctgctactg aggacctcac tttgatctgg ggagcgggta cgaagctcat aataaaaccc     2460

gatatccaaa acccggaccc agcagtttat caattgagag atagtaagtc cagtgacaaa     2520

tcagtttgtt tgtttacgga tttcgatagc cagaccaatg tcagtcagtc aaaggacagt     2580

gatgtataca ttacagataa atgtgtactt gacatgcgct caatggactt taagtctaac     2640

tctgctgtag cttggtctaa caaaagtgat tttgcgtgtg ccaacgcatt taacaacagc     2700

atcatacctg aagacacgtt ctttccgagt ccagaaagtt cctgtgacgt gaaacttgta     2760

gaaaagagtt tcgagaccga cactaacctt aactttcaaa acctttcagt gatcggattt     2820

agaatcttgc tgctcaaggt ggcagggttc aatctgctga tgactctgcg actgtggagt     2880

tcataacctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc     2940

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     3000

catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     3060

agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggctt     3120

ctgaggcgga aagaaccagc tggggctcta gggggtatcc ccaccagctg agagactcta     3180

aatccagtga caagtctgtc tgcctattca ccgattttga ttctcaaaca aatgtgtcac     3240

aaagtaagga ttctgatgtg tatatcacag acaaaactgt gctagacatg aggtctatgg     3300

acttcaagag caacagtgct gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg     3360

ccttcaacaa cagcattatt ccagaagaca ccttcttccc cagcccaggt aagggcagct     3420

ttggtgcctt cgcaggctgt ttccttgctt caggaatggc caggttctgc ccagagctct     3480

ggtcaatgat gtctaaaact cctctgattg gtggtctcgg ccttatccat tgccaccaaa     3540

accctctttt tactaagaaa cagtgagcct tgttctggca gtccagagaa tgacacggga     3600

aaaaagcaga tgaagagaag gtggcaggag agggcacgtg gcccagcctc agtctctcca     3660

acagatctag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     3720

cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt     3780

gagcgagcga gcgcgcagag agggagtggc caaacgcgtg                           3820


<210>  621
<211>  3638
<212>  DNA
<213>  Homo sapiens

<400>  621
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc tcaatgagag agcaatctcc tggtaatgtg      180

atagatttcc caacttaatg ccaacatacc ataaacctcc cattctgcta atgcccagcc      240

taagttgggg agaccactcc agattccaag atgtacagtt tgctttgctg ggcctttttc      300

ccatgcctgc ctttactctg ccagagttat attgctgggg ttttgaagaa gatcctatta      360

aataaaagaa taagcagtat tattaagtag ccctgcattt caggtttcct tgagtggcag      420

gccaggcctg gccgtgaacg ttcactgaaa tcatggcctc ttggccaaga ttgatagctt      480

gtgcctgtcc ctgagtccca gtccatcacg agcagctggt ttctaagatg ctatttcccg      540

tataaagcat gagaccgtga cttgccagcc ccacagagcc ccgcccttgt ccatcactgg      600

catctggact ccagcctggg ttggggcaaa gagggaaatg agatcatgtc cgagtaattc      660

atacaaaagg actcgcccct gccttgggga atcccaggga ccgtcgttaa actcccacta      720

acgtagaacc cagagatcgc tgcgttcccg ccccctcacc cgcccgctct cgtcatcact      780

gaggtggaga agagcatgcg tgaggctccg gtgcccgtca gtgggcagag cgcacatcgc      840

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      900

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      960

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg     1020

ccgccagaac acaggtaagt gccgtgtgtg gttcccgcgg gcctggcctc tttacgggtt     1080

atggcccttg cgtgccttga attacttcca cgcccctggc tgcagtacgt gattcttgat     1140

cccgagcttc gggttggaag tgggtgggag agttcgaggc cttgcgctta aggagcccct     1200

tcgcctcgtg cttgagttga ggcctggctt gggcgctggg gccgccgcgt gcgaatctgg     1260

tggcaccttc gcgcctgtct cgctgctttc gataagtctc tagccattta aaatttttga     1320

tgacctgctg cgacgctttt tttctggcaa gatagtcttg taaatgcggg ccaacatctg     1380

cacactggta tttcggtttt tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc     1440

acatgttcgg cgaggcgggg cctgcgagcg cggccaccga gaatcggacg ggggtagtct     1500

caagctggcc ggcctgctct ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg     1560

gcggcaaggc tggcccggtc ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc     1620

cctgctgcag ggagctcaaa atggaggacg cggcgctcgg gagagcgggc gggtgagtca     1680

cccacacaaa ggaaaagggc ctttccgtcc tcagccgtcg cttcatgtga ctccacggag     1740

taccgggcgc cgtccaggca cctcgattag ttctcgagct tttggagtac gtcgtcttta     1800

ggttgggggg aggggtttta tgcgatggag tttccccaca ctgagtgggt ggagactgaa     1860

gttaggccag cttggcactt gatgtaattc tccttggaat ttgccctttt tgagtttgga     1920

tcttggttca ttctcaagcc tcagacagtg gttcaaagtt tttttcttcc atttcaggtg     1980

tcgtgacacc ggtcgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     2040

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     2100

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     2160

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     2220

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     2280

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     2340

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     2400

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     2460

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     2520

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     2580

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     2640

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     2700

tggacgagct gtacaagtaa tagcggccgc gactctagat cataatcagc cataccacat     2760

ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata     2820

aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa     2880

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt     2940

tgtccaaact catcaatgta tcttaaggcg ttgacaagtc tgtctgccta ttcaccgatt     3000

ttgattctca aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa     3060

ctgtgctaga catgaggtct atggacttca agagcaacag tgctgtggcc tggagcaaca     3120

aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa gacaccttct     3180

tccccagccc aggtaagggc agctttggtg ccttcgcagg ctgtttcctt gcttcaggaa     3240

tggccaggtt ctgcccagag ctctggtcaa tgatgtctaa aactcctctg attggtggtc     3300

tcggccttat ccattgccac caaaaccctc tttttactaa gaaacagtga gccttgttct     3360

ggcagtccag agaatgacac gggaaaaaag cagatgaaga gaaggtggca ggagagggca     3420

cgtggcccag cctcagtctc tccaactgag ttcctgcctg cctgcctttg cagatctagg     3480

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     3540

cccgggcaaa gcccgggcgt cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag     3600

cgcgcagaga gggagtggcc aaacgcgtgg tgtaatca                             3638


<210>  622
<211>  2382
<212>  DNA
<213>  Homo sapiens

<400>  622
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgagggccg      660

cggcagcctg ctgacctgcg gcgacgtgga ggagaatccc ggccccatgg tgagcaaggg      720

cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg      780

ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct      840

gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct      900

gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt      960

caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg     1020

caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga     1080

gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa     1140

ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa     1200

cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca     1260

gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca     1320

gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt     1380

gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaacctc gactgtgcct     1440

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     1500

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     1560

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     1620

aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc     1680

tggggctcta gggggtatcc ccactagtcg tgtaccagct gagagactct aaatccagtg     1740

acaagtctgt ctgcctattc accgattttg attctcaaac aaatgtgtca caaagtaagg     1800

attctgatgt gtatatcaca gacaaaactg tgctagacat gaggtctatg gacttcaaga     1860

gcaacagtgc tgtggcctgg agcaacaaat ctgactttgc atgtgcaaac gccttcaaca     1920

acagcattat tccagaagac accttcttcc ccagcccagg taagggcagc tttggtgcct     1980

tcgcaggctg tttccttgct tcaggaatgg ccaggttctg cccagagctc tggtcaatga     2040

tgtctaaaac tcctctgatt ggtggtctcg gccttatcca ttgccaccaa aaccctcttt     2100

ttactaagaa acagtgagcc ttgttctggc agtccagaga atgacacggg aaaaaagcag     2160

atgaagagaa ggtggcagga gagggcacgt ggcccagcct cagtctctag atctaggaac     2220

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgccc     2280

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     2340

gcagagaggg agtggccaag aattctctgg ccgtcgtttt ac                        2382


<210>  623
<211>  4618
<212>  DNA
<213>  Homo sapiens

<400>  623
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg cggctccggt      660

gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc      720

ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg      780

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc      840

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt      900

tcccgcgggc ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg      960

cccctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag     1020

ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcttgg     1080

gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga     1140

taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga     1200

tagtcttgta aatgcgggcc aagatgtgca cactggtatt tcggtttttg gggccgcggg     1260

cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg     1320

gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct     1380

cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc     1440

gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg     1500

gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc     1560

agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt     1620

ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt     1680

tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc     1740

cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt     1800

tcaaagtttt tttcttccat ttcaggtgtc gtgatgcggc cgccaccatg ggatcttgga     1860

cactgtgttg cgtgtccctg tgcatcctgg tggccaagca cacagatgcc ggcgtgatcc     1920

agtctcctag acacgaagtg accgagatgg gccaagaagt gaccctgcgc tgcaagccta     1980

tcagcggcca cgattacctg ttctggtaca gacagaccat gatgagaggc ctggaactgc     2040

tgatctactt caacaacaac gtgcccatcg acgacagcgg catgcccgag gatagattca     2100

gcgccaagat gcccaacgcc agcttcagca ccctgaagat ccagcctagc gagcccagag     2160

atagcgccgt gtacttctgc gccagcagaa agacaggcgg ctacagcaat cagccccagc     2220

actttggaga tggcacccgg ctgagcatcc tggaagatct gaagaacgtg ttcccacctg     2280

aggtggccgt gttcgagcct tctgaggccg agatcagcca cacacagaaa gccacactcg     2340

tgtgtctggc caccggcttc tatcccgatc acgtggaact gtcttggtgg gtcaacggca     2400

aagaggtgca cagcggcgtc agcaccgatc ctcagcctct gaaagagcag cccgctctga     2460

acgacagcag atactgcctg agcagcagac tgagagtgtc cgccaccttc tggcagaacc     2520

ccagaaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac gatgagtgga     2580

cccaggatag agccaagcct gtgacacaga tcgtgtctgc cgaagcctgg ggcagagccg     2640

attgtggctt taccagcgag agctaccagc agggcgtgct gtctgccaca atcctgtacg     2700

agatcctgct gggcaaagcc actctgtacg ccgtgctggt gtctgccctg gtgctgatgg     2760

ccatggtcaa gcggaaggat agcaggggcg gctccggtgc cacaaacttc tccctgctca     2820

agcaggccgg agatgtggaa gagaaccctg gccctatgga aaccctgctg aaggtgctga     2880

gcggcacact gctgtggcag ctgacatggg tccgatctca gcagcctgtg cagtctcctc     2940

aggccgtgat tctgagagaa ggcgaggacg ccgtgatcaa ctgcagcagc tctaaggccc     3000

tgtacagcgt gcactggtac agacagaagc acggcgaggc ccctgtgttc ctgatgatcc     3060

tgctgaaagg cggcgagcag aagggccacg agaagatcag cgccagcttc aacgagaaga     3120

agcagcagtc cagcctgtac ctgacagcca gccagctgag ctacagcggc acctactttt     3180

gtggcaccgc ctggatcaac gactacaagc tgtctttcgg agccggcacc acagtgacag     3240

tgcgggccaa tattcagaac cccgatcctg ccgtgtacca gctgagagac agcaagagca     3300

gcgacaagag cgtgtgcctg ttcaccgact tcgacagcca gaccaacgtg tcccagagca     3360

aggacagcga cgtgtacatc accgataaga ctgtgctgga catgcggagc atggacttca     3420

agagcaacag cgccgtggcc tggtccaaca agagcgattt cgcctgcgcc aacgccttca     3480

acaacagcat tatccccgag gacacattct tcccaagtcc tgagagcagc tgcgacgtga     3540

agctggtgga aaagagcttc gagacagaca ccaacctgaa cttccagaac ctgagcgtga     3600

tcggcttcag aatcctgctg ctcaaggtgg ccggcttcaa cctgctgatg accctgagac     3660

tgtggtccag ctaacctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc     3720

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     3780

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     3840

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc     3900

tatggcttct gaggcggaaa gaaccagctg gggctctagg gggtatcccc actagtcgtg     3960

taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat     4020

tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg     4080

ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct     4140

gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc     4200

agcccaggta agggcagctt tggtgccttc gcaggctgtt tccttgcttc aggaatggcc     4260

aggttctgcc cagagctctg gtcaatgatg tctaaaactc ctctgattgg tggtctcggc     4320

cttatccatt gccaccaaaa ccctcttttt actaagaaac agtgagcctt gttctggcag     4380

tccagagaat gacacgggaa aaaagcagat gaagagaagg tggcaggaga gggcacgtgg     4440

cccagcctca gtctctagat ctaggaaccc ctagtgatgg agttggccac tccctctctg     4500

cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt     4560

cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaagaa ttctctgg       4618


<210>  624
<211>  4587
<212>  DNA
<213>  Homo sapiens

<400>  624
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg cggctccggt      660

gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc      720

ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg      780

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc      840

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt      900

tcccgcgggc ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg      960

cccctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag     1020

ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcttgg     1080

gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga     1140

taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga     1200

tagtcttgta aatgcgggcc aagatgtgca cactggtatt tcggtttttg gggccgcggg     1260

cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg     1320

gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct     1380

cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc     1440

gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg     1500

gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc     1560

agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt     1620

ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt     1680

tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc     1740

cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt     1800

tcaaagtttt tttcttccat ttcaggtgtc gtgacggccg gccccgccac catgagcaat     1860

caagtccttt gttgtgttgt cctgtgtttc cttggcgcaa ataccgtcga cggcgggata     1920

actcagtccc ccaaatacct cttcagaaaa gaaggacaaa acgtaacgct ttcctgcgag     1980

cagaatctta accacgacgc catgtactgg tacaggcaag accctggaca aggtcttagg     2040

ctcatatact actctcagat tgtcaatgac ttccaaaaag gggacatagc tgagggctac     2100

tctgtgtccc gagagaagaa ggagtcattt cccctgacag tgacttctgc acaaaaaaat     2160

cccactgcat tttatttgtg tgccagttca ccgggtgcat tgtatgagca atactttggc     2220

cccggcacta gactgacagt tacggaggat ctgaaaaacg tcttcccgcc agaggtggca     2280

gttttcgagc ccagtgaggc tgaaatctct catacccaaa aagcaaccct tgtctgtctc     2340

gccactggat tctatcccga ccacgtcgaa ttgagctggt gggtcaatgg gaaagaggta     2400

catagtgggg tctgtacgga tccacaaccc cttaaggaac aacctgccct taacgattca     2460

cgatactgcc tgtcatcacg actcagggta tctgctacct tttggcagaa cccgagaaat     2520

cactttcggt gccaggttca gttttacgga cttagcgaaa atgatgaatg gacacaagac     2580

cgagcaaagc ccgttactca aatagtgagc gcggaagcct gggggcgagc agactgcggc     2640

ttcacctccg aaagttacca gcaaggtgtt ttgtcagcca ccattttgta tgagattttg     2700

ttggggaagg cgacacttta cgcggtactg gtctctgcct tggttcttat ggctatggtc     2760

aagaggaaag attccagggg tggctccggt gccacaaact tctccctgct caagcaggcc     2820

ggagatgtgg aagagaaccc tggccctatg acctctatca gagctgtctt tatatttctc     2880

tggcttcaac ttgatctggt gaatggcgaa aacgtggaac agcacccttc aacgttgagc     2940

gttcaggaag gagattcagc cgtcatcaag tgtacgtatt ccgattccgc gtcaaactac     3000

ttcccgtggt acaaacagga acttggcaag cgcccccagc tcattatcga catcagaagc     3060

aacgtaggag agaagaagga ccaacgcata gctgtgactc tcaacaaaac agctaaacat     3120

ttctccctgc acattacgga aacccaacca gaggattctg ccgtatactt ttgtgctgct     3180

actgaggacc tcactttgat ctggggagcg ggtacgaagc tcataataaa acccgatatc     3240

caaaacccgg acccagcagt ttatcaattg agagatagta agtccagtga caaatcagtt     3300

tgtttgttta cggatttcga tagccagacc aatgtcagtc agtcaaagga cagtgatgta     3360

tacattacag ataaatgtgt acttgacatg cgctcaatgg actttaagtc taactctgct     3420

gtagcttggt ctaacaaaag tgattttgcg tgtgccaacg catttaacaa cagcatcata     3480

cctgaagaca cgttctttcc gagtccagaa agttcctgtg acgtgaaact tgtagaaaag     3540

agtttcgaga ccgacactaa ccttaacttt caaaaccttt cagtgatcgg atttagaatc     3600

ttgctgctca aggtggcagg gttcaatctg ctgatgactc tgcgactgtg gagttcataa     3660

cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     3720

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     3780

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     3840

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg gcttctgagg     3900

cggaaagaac cagctggggc tctagggggt atcccccgtg taccagctga gagactctaa     3960

atccagtgac aagtctgtct gcctattcac cgattttgat tctcaaacaa atgtgtcaca     4020

aagtaaggat tctgatgtgt atatcacaga caaaactgtg ctagacatga ggtctatgga     4080

cttcaagagc aacagtgctg tggcctggag caacaaatct gactttgcat gtgcaaacgc     4140

cttcaacaac agcattattc cagaagacac cttcttcccc agcccaggta agggcagctt     4200

tggtgccttc gcaggctgtt tccttgcttc aggaatggcc aggttctgcc cagagctctg     4260

gtcaatgatg tctaaaactc ctctgattgg tggtctcggc cttatccatt gccaccaaaa     4320

ccctcttttt actaagaaac agtgagcctt gttctggcag tccagagaat gacacgggaa     4380

aaaagcagat gaagagaagg tggcaggaga gggcacgtgg cccagcctca gtctctagat     4440

ctaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     4500

ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt cgcccggcct cagtgagcga     4560

gcgagcgcgc agagagggag tggccaa                                         4587


<210>  625
<211>  4630
<212>  DNA
<213>  Homo sapiens

<400>  625
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg cggctccggt      660

gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc      720

ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg      780

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc      840

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt      900

tcccgcgggc ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg      960

cccctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag     1020

ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcttgg     1080

gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga     1140

taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga     1200

tagtcttgta aatgcgggcc aagatgtgca cactggtatt tcggtttttg gggccgcggg     1260

cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg     1320

gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct     1380

cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc     1440

gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg     1500

gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc     1560

agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt     1620

ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt     1680

tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc     1740

cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt     1800

tcaaagtttt tttcttccat ttcaggtgtc gtgatgcggc cgccaccatg ggatcttgga     1860

cactgtgttg cgtgtccctg tgcatcctgg tggccaagca cacagatgcc ggcgtgatcc     1920

agtctcctag acacgaagtg accgagatgg gccaagaagt gaccctgcgc tgcaagccta     1980

tcagcggcca cgattacctg ttctggtaca gacagaccat gatgagaggc ctggaactgc     2040

tgatctactt caacaacaac gtgcccatcg acgacagcgg catgcccgag gatagattca     2100

gcgccaagat gcccaacgcc agcttcagca ccctgaagat ccagcctagc gagcccagag     2160

atagcgccgt gtacttctgc gccagcagaa agacaggcgg ctacagcaat cagccccagc     2220

actttggaga tggcacccgg ctgagcatcc tggaagatct gaagaacgtg ttcccacctg     2280

aggtggccgt gttcgagcct tctgaggccg agatcagcca cacacagaaa gccacactcg     2340

tgtgtctggc caccggcttc tatcccgatc acgtggaact gtcttggtgg gtcaacggca     2400

aagaggtgca cagcggcgtc tgtaccgatc ctcagcctct gaaagagcag cccgctctga     2460

acgacagcag atactgcctg agcagcagac tgagagtgtc cgccaccttc tggcagaacc     2520

ccagaaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac gatgagtgga     2580

cccaggatag agccaagcct gtgacacaga tcgtgtctgc cgaagcctgg ggcagagccg     2640

attgtggctt taccagcgag agctaccagc agggcgtgct gtctgccaca atcctgtacg     2700

agatcctgct gggcaaagcc actctgtacg ccgtgctggt gtctgccctg gtgctgatgg     2760

ccatggtcaa gcggaaggat agcaggggcg gctccggtgc cacaaacttc tccctgctca     2820

agcaggccgg agatgtggaa gagaaccctg gccctatgga aaccctgctg aaggtgctga     2880

gcggcacact gctgtggcag ctgacatggg tccgatctca gcagcctgtg cagtctcctc     2940

aggccgtgat tctgagagaa ggcgaggacg ccgtgatcaa ctgcagcagc tctaaggccc     3000

tgtacagcgt gcactggtac agacagaagc acggcgaggc ccctgtgttc ctgatgatcc     3060

tgctgaaagg cggcgagcag aagggccacg agaagatcag cgccagcttc aacgagaaga     3120

agcagcagtc cagcctgtac ctgacagcca gccagctgag ctacagcggc acctactttt     3180

gtggcaccgc ctggatcaac gactacaagc tgtctttcgg agccggcacc acagtgacag     3240

tgcgggccaa tattcagaac cccgatcctg ccgtgtacca gctgagagac agcaagagca     3300

gcgacaagag cgtgtgcctg ttcaccgact tcgacagcca gaccaacgtg tcccagagca     3360

aggacagcga cgtgtacatc accgataagt gcgtgctgga catgcggagc atggacttca     3420

agagcaacag cgccgtggcc tggtccaaca agagcgattt cgcctgcgcc aacgccttca     3480

acaacagcat tatccccgag gacacattct tcccaagtcc tgagagcagc tgcgacgtga     3540

agctggtgga aaagagcttc gagacagaca ccaacctgaa cttccagaac ctgagcgtga     3600

tcggcttcag aatcctgctg ctcaaggtgg ccggcttcaa cctgctgatg accctgagac     3660

tgtggtccag ctaacctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc     3720

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     3780

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     3840

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc     3900

tatggcttct gaggcggaaa gaaccagctg gggctctagg gggtatcccc actagtcgtg     3960

taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat     4020

tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg     4080

ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct     4140

gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc     4200

agcccaggta agggcagctt tggtgccttc gcaggctgtt tccttgcttc aggaatggcc     4260

aggttctgcc cagagctctg gtcaatgatg tctaaaactc ctctgattgg tggtctcggc     4320

cttatccatt gccaccaaaa ccctcttttt actaagaaac agtgagcctt gttctggcag     4380

tccagagaat gacacgggaa aaaagcagat gaagagaagg tggcaggaga gggcacgtgg     4440

cccagcctca gtctctagat ctaggaaccc ctagtgatgg agttggccac tccctctctg     4500

cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt     4560

cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaagaa ttctctggcc     4620

gtcgttttac                                                            4630


<210>  626
<211>  4654
<212>  DNA
<213>  Homo sapiens

<400>  626
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg cggctccggt      660

gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc      720

ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg      780

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc      840

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt      900

tcccgcgggc ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg      960

cccctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag     1020

ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcttgg     1080

gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga     1140

taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga     1200

tagtcttgta aatgcgggcc aagatgtgca cactggtatt tcggtttttg gggccgcggg     1260

cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg     1320

gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct     1380

cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc     1440

gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg     1500

gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc     1560

agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt     1620

ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt     1680

tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc     1740

cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt     1800

tcaaagtttt tttcttccat ttcaggtgtc gtgatgcggc cgccaccatg ctgagccccg     1860

atctgcctga cagcgcctgg aacaccagac tgctgtgcca cgtgatgctg tgcctgctgg     1920

gagccgtgtc tgtggctgct ggcgtgatcc agagccccag acacctgatc aaagagaaga     1980

gagagacagc caccctgaag tgctacccca tccccaggca cgacaccgtg tactggtatc     2040

agcagggccc aggccaggac ccccagttcc tgatcagctt ctacgagaag atgcagagcg     2100

acaagggcag catccccgac agattcagcg cccagcagtt cagcgactac cacagcgagc     2160

tgaacatgag cagcctggaa ctgggcgaca gcgccctgta cttctgtgcc agctctctga     2220

gaggcggcct ggaaaagctg ttcttcggca gcggcaccca gctgagcgtg ctggaagacc     2280

tgaacaaggt gttcccccca gaggtggccg tgttcgagcc ttctgaggcc gaaatctccc     2340

acacccagaa agccaccctc gtgtgcctgg ccaccggctt tttccccgac cacgtggaac     2400

tgtcttggtg ggtcaacggc aaagaggtgc actccggcgt gtgcaccgat ccccagcctc     2460

tgaaagaaca gcccgccctg aacgacagcc ggtactgcct gagcagcaga ctgagagtgt     2520

ccgccacctt ctggcagaac ccccggaacc acttcagatg ccaggtgcag ttctacggcc     2580

tgagcgagaa cgacgagtgg acccaggaca gagccaagcc cgtgacacag atcgtgtctg     2640

ccgaagcctg gggcagagcc gattgcggct ttacctccgt gtcctatcag cagggcgtgc     2700

tgagcgccac aatcctgtac gagatcctgc tgggcaaggc caccctgtac gccgtgctgg     2760

tgtctgccct ggtgctgatg gccatggtca agcggaagga cttcggttcc ggagccacga     2820

acttctctct gttaaagcaa gcaggagacg tggaagaaaa ccccggtccc atgagcctga     2880

gcagcctgct gaaagtcgtg accgccagcc tgtggctggg acctggaatc gcccagaaga     2940

tcacccagac ccagcccggc atgttcgtgc aggaaaaaga agccgtgacc ctggactgca     3000

cctacgacac cagcgaccct agctacggcc tgttctggta caagcagccc agcagcggcg     3060

agatgatctt cctgatctac cagggcagct acgaccagca gaacgccacc gagggccggt     3120

acagcctgaa cttccagaag gcccggaagt ccgccaacct cgtgatcagc gccagccagc     3180

tgggcgacag cgccatgtac ttttgcgcca tcagcggcaa cacccccctg gtgtttggca     3240

agggcacccg gctgagcgtg atcgccaaca tccagaaccc cgaccccgca gtgtaccagc     3300

tgcgggacag caagagcagc gacaagagcg tgtgcctgtt caccgacttc gacagccaga     3360

ccaacgtgtc ccagagcaag gacagcgacg tgtacatcac cgataagtgc gtgctggaca     3420

tgcggagcat ggacttcaag agcaacagcg ccgtggcctg gtccaacaag agcgacttcg     3480

cctgcgccaa cgccttcaac aacagcatta tccccgagga cacattcttc ccaagccccg     3540

agagcagctg cgacgtgaag ctggtggaaa agagcttcga gacagacacc aacctgaact     3600

tccagaacct cagcgtgatc ggcttccgga tcctgctgct gaaggtggcc ggcttcaacc     3660

tgctgatgac cctgcggctg tggtccagct aatcgatcct cgactgtgcc ttctagttgc     3720

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     3780

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     3840

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     3900

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggctct     3960

agggggtatc cccactagtc gtgtaccagc tgagagactc taaatccagt gacaagtctg     4020

tctgcctatt caccgatttt gattctcaaa caaatgtgtc acaaagtaag gattctgatg     4080

tgtatatcac agacaaaact gtgctagaca tgaggtctat ggacttcaag agcaacagtg     4140

ctgtggcctg gagcaacaaa tctgactttg catgtgcaaa cgccttcaac aacagcatta     4200

ttccagaaga caccttcttc cccagcccag gtaagggcag ctttggtgcc ttcgcaggct     4260

gtttccttgc ttcaggaatg gccaggttct gcccagagct ctggtcaatg atgtctaaaa     4320

ctcctctgat tggtggtctc ggccttatcc attgccacca aaaccctctt tttactaaga     4380

aacagtgagc cttgttctgg cagtccagag aatgacacgg gaaaaaagca gatgaagaga     4440

aggtggcagg agagggcacg tggcccagcc tcagtctcta gatctaggaa cccctagtga     4500

tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc     4560

ccgggcgtcg ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg     4620

gagtggccaa gaattctctg gccgtcgttt taca                                 4654


<210>  627
<211>  4638
<212>  DNA
<213>  Homo sapiens

<400>  627
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg cggctccggt      660

gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc      720

ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg      780

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc      840

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt      900

tcccgcgggc ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg      960

cccctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag     1020

ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcttgg     1080

gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga     1140

taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga     1200

tagtcttgta aatgcgggcc aagatgtgca cactggtatt tcggtttttg gggccgcggg     1260

cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg     1320

gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct     1380

cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc     1440

gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg     1500

gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc     1560

agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt     1620

ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt     1680

tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc     1740

cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt     1800

tcaaagtttt tttcttccat ttcaggtgtc gtgatgcggc cgccaccatg ggcaccagac     1860

tgctgtgttg ggccgctctg tgtctgctgg gagccgaact gactgaagct ggcgtggccc     1920

agagcccccg gtacaagatc atcgagaagc ggcagagcgt ggccttctgg tgcaacccta     1980

tcagcggaca cgccaccctg tactggtatc agcagatcct gggccagggc cccaagctgc     2040

tgattcagtt ccagaacaac ggcgtggtgg acgacagcca gctgcccaag gatagattca     2100

gcgccgagcg gctgaagggc gtggacagca cactgaagat ccagcccgcc aagctggaag     2160

atagcgccgt gtacctgtgc gccagcagcc tgtatagagg cgagcagtac ttcggccctg     2220

gcacccggct gaccgtgacc gaggatctga agaacgtgtt ccccccagag gtggccgtgt     2280

tcgagcctag cgaggccgag atcagccaca cccagaaagc caccctcgtg tgcctggcca     2340

ccggctttta ccccgaccac gtggaactgt cttggtgggt caacggcaaa gaggtgcaca     2400

gcggcgtctg caccgacccc cagcccctga aagagcagcc cgccctgaac gacagccggt     2460

actgtctgag cagcagactg agagtgtccg ccaccttctg gcagaacccc cggaaccact     2520

tcagatgcca ggtgcagttc tacggcctga gcgagaacga cgagtggacc caggaccggg     2580

ccaagcccgt gacccagatc gtgtctgctg aggcctgggg cagagccgat tgcggcttca     2640

ccagcgagag ctaccagcag ggcgtgctga gcgccaccat cctgtacgag atcctgctgg     2700

gcaaggccac cctgtacgcc gtgctggtgt ccgccctggt gctgatggcc atggtcaagc     2760

ggaaggacag ccggggcggt tccggagcca cgaacttctc tctgttaaag caagcaggag     2820

acgtggaaga aaaccccggt cccatggcta tgctgctggg cgcctctgtg ctgatcctgt     2880

ggctgcagcc cgactgggtc aacagccagc agaagaacga cgaccagcaa gtgaagcaga     2940

acagccccag cctgagcgtg caggaaggcc ggatcagcat cctgaactgc gactacacca     3000

actctatgtt cgactacttc ctgtggtaca agaagtaccc cgccgagggc cccaccttcc     3060

tgatctccat cagcagcatc aaggacaaga acgaggacgg ccggttcacc gtgtttctga     3120

acaagagcgc caagcacctg agcctgcaca tcgtgcctag ccagcctggc gatagcgccg     3180

tgtacttctg tgccgccaga ggccagggca acctgatctt tggcaagggc accaagctga     3240

gcgtgaagcc caacatccag aaccccgacc ccgcagtgta ccagctgcgg gacagcaaga     3300

gcagcgacaa gagcgtgtgc ctgttcaccg acttcgacag ccagaccaac gtgtcccaga     3360

gcaaggacag cgacgtgtac atcaccgata agtgcgtgct ggacatgcgg agcatggact     3420

tcaagagcaa cagcgccgtg gcctggtcca acaagagcga cttcgcctgc gccaacgcct     3480

tcaacaacag cattatcccc gaggacacat tcttcccaag ccccgagagc agctgcgacg     3540

tgaagctggt ggaaaagagc ttcgagacag acaccaacct gaacttccag aacctcagcg     3600

tgatcggctt ccggatcctg ctgctgaagg tggccggctt caacctgctg atgaccctgc     3660

ggctgtggtc cagctaatcg atcctcgact gtgccttcta gttgccagcc atctgttgtt     3720

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa     3780

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg     3840

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg     3900

gtgggctcta tggcttctga ggcggaaaga accagctggg gctctagggg gtatccccac     3960

tagtcgtgta ccagctgaga gactctaaat ccagtgacaa gtctgtctgc ctattcaccg     4020

attttgattc tcaaacaaat gtgtcacaaa gtaaggattc tgatgtgtat atcacagaca     4080

aaactgtgct agacatgagg tctatggact tcaagagcaa cagtgctgtg gcctggagca     4140

acaaatctga ctttgcatgt gcaaacgcct tcaacaacag cattattcca gaagacacct     4200

tcttccccag cccaggtaag ggcagctttg gtgccttcgc aggctgtttc cttgcttcag     4260

gaatggccag gttctgccca gagctctggt caatgatgtc taaaactcct ctgattggtg     4320

gtctcggcct tatccattgc caccaaaacc ctctttttac taagaaacag tgagccttgt     4380

tctggcagtc cagagaatga cacgggaaaa aagcagatga agagaaggtg gcaggagagg     4440

gcacgtggcc cagcctcagt ctctagatct aggaacccct agtgatggag ttggccactc     4500

cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga     4560

cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg gccaagaatt     4620

ctctggccgt cgttttac                                                   4638


<210>  628
<211>  4737
<212>  DNA
<213>  Homo sapiens

<400>  628
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg cggctccggt      660

gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc      720

ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg      780

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc      840

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt      900

tcccgcgggc ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg      960

cccctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag     1020

ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcttgg     1080

gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga     1140

taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga     1200

tagtcttgta aatgcgggcc aagatgtgca cactggtatt tcggtttttg gggccgcggg     1260

cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg     1320

gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct     1380

cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc     1440

gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg     1500

gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc     1560

agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt     1620

ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt     1680

tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc     1740

cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt     1800

tcaaagtttt tttcttccat ttcaggtgtc gtgatgcggc cgccaccatg tctctgggcc     1860

tgctgtgctg tggcgccttc tctctgctgt gggccggacc tgtgaatgcc ggcgtgaccc     1920

agacccccaa gttccgggtg ctgaaaaccg gccagagcat gaccctgctg tgtgcccagg     1980

acatgaacca cgagtacatg tattggtaca gacaggaccc cggcatgggc ctgcggctga     2040

tccactattc tgtgggcgag ggcaccaccg ccaagggcga agtgcctgat ggctacaacg     2100

tgtcccggct gaagaagcag aacttcctgc tgggcctgga aagcgccgct cctagccaga     2160

ccagcgtgta cttctgtgcc agccggggct accaccggct gaacaacgag cagttcttcg     2220

gccctggcac ccggctgacc gtgctggaag acctgaagaa cgtgttcccc ccagaggtgg     2280

ccgtgttcga gcctagcgag gccgagatca gccacaccca gaaagccacc ctcgtgtgcc     2340

tggccaccgg cttttacccc gaccacgtgg aactgtcttg gtgggtcaac ggcaaagagg     2400

tgcacagcgg cgtctgcacc gacccccagc ccctgaaaga gcagcccgcc ctgaacgaca     2460

gccggtactg tctgagcagc agactgagag tgtccgccac cttctggcag aacccccgga     2520

accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag tggacccagg     2580

accgggccaa gcccgtgacc cagatcgtgt ctgctgaggc ctggggcaga gccgattgcg     2640

gcttcaccag cgagagctac cagcagggcg tgctgagcgc caccatcctg tacgagatcc     2700

tgctgggcaa ggccaccctg tacgccgtgc tggtgtccgc cctggtgctg atggccatgg     2760

tcaagcggaa ggacagccgg ggcggttccg gagccacgaa cttctctctg ttaaagcaag     2820

caggagacgt ggaagaaaac cccggtccca tgatcagcct gcgggtgctg ctcgtgatcc     2880

tgtggctgca gctgagctgg gtgtggtccg gaggtgggtc atggtcccat ccgcaattcg     2940

aaaagggagg tgggtcaggt ggaggaagcg gcggatccgc gtggtcacat cctcagttcg     3000

aaaagcagcg gaaagaggtg gaacaggacc ctggcccctt caacgtgcca gagggcgcca     3060

ccgtggcctt caactgcacc tacagcaaca gcgccagcca gagcttcttc tggtacagac     3120

aggactgccg gaaagaaccc aagctgctga tgagcgtgta cagcagcggc aacgaggacg     3180

gcagattcac cgcccagctg aacagagcct cccagtacat ctccctgctg atccgggaca     3240

gcaagctgag cgacagcgcc acctacctgt gcgtcgtgaa gcctgatcct ggcgccggaa     3300

gctaccagct gacctttggc aagggcacca agctgtccgt gatccccaac atccagaacc     3360

ccgaccccgc agtgtaccag ctgcgggaca gcaagagcag cgacaagagc gtgtgcctgt     3420

tcaccgactt cgacagccag accaacgtgt cccagagcaa ggacagcgac gtgtacatca     3480

ccgataagtg cgtgctggac atgcggagca tggacttcaa gagcaacagc gccgtggcct     3540

ggtccaacaa gagcgacttc gcctgcgcca acgccttcaa caacagcatt atccccgagg     3600

acacattctt cccaagcccc gagagcagct gcgacgtgaa gctggtggaa aagagcttcg     3660

agacagacac caacctgaac ttccagaacc tcagcgtgat cggcttccgg atcctgctgc     3720

tgaaggtggc cggcttcaac ctgctgatga ccctgcggct gtggtccagc taatcgatcc     3780

tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     3840

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     3900

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     3960

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg     4020

gaaagaacca gctggggctc tagggggtat ccccactagt cgtgtaccag ctgagagact     4080

ctaaatccag tgacaagtct gtctgcctat tcaccgattt tgattctcaa acaaatgtgt     4140

cacaaagtaa ggattctgat gtgtatatca cagacaaaac tgtgctagac atgaggtcta     4200

tggacttcaa gagcaacagt gctgtggcct ggagcaacaa atctgacttt gcatgtgcaa     4260

acgccttcaa caacagcatt attccagaag acaccttctt ccccagccca ggtaagggca     4320

gctttggtgc cttcgcaggc tgtttccttg cttcaggaat ggccaggttc tgcccagagc     4380

tctggtcaat gatgtctaaa actcctctga ttggtggtct cggccttatc cattgccacc     4440

aaaaccctct ttttactaag aaacagtgag ccttgttctg gcagtccaga gaatgacacg     4500

ggaaaaaagc agatgaagag aaggtggcag gagagggcac gtggcccagc ctcagtctct     4560

agatctagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     4620

ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga     4680

gcgagcgagc gcgcagagag ggagtggcca agaattctct ggccgtcgtt ttacaac        4737


<210>  629
<211>  4646
<212>  DNA
<213>  Homo sapiens

<400>  629
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg cggctccggt      660

gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc      720

ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg      780

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc      840

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt      900

tcccgcgggc ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg      960

cccctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag     1020

ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcttgg     1080

gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga     1140

taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga     1200

tagtcttgta aatgcgggcc aagatgtgca cactggtatt tcggtttttg gggccgcggg     1260

cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg     1320

gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct     1380

cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc     1440

gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg     1500

gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc     1560

agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt     1620

ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt     1680

tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc     1740

cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt     1800

tcaaagtttt tttcttccat ttcaggtgtc gtgatgcggc cgccaccatg ggatgtagac     1860

ttctgtgttg cgccgtgctg tgtctgcttg gagctggcga actggtgcct atggaaaccg     1920

gcgtgaccca gacacctaga cacctggtca tgggcatgac aaacaagaaa agcctgaagt     1980

gcgagcagca cctgggccac aatgccatgt actggtacaa gcagagcgcc aagaaacccc     2040

tggaactgat gttcgtgtac agcctggaag agagggtcga gaacaacagc gtgcccagca     2100

gattcagccc tgagtgccct aatagcagcc acctgtttct gcatctgcac accctgcagc     2160

ctgaggactc tgccctgtat ctgtgtgcca gcagccagga ctacctggtg tccaacgaga     2220

agctgttctt cggcagcggc acacagctga gcgtgctgga agatctgaag aacgtgttcc     2280

cacctgaggt ggccgtgttc gagccttctg aggccgagat cagccacaca cagaaagcca     2340

cactcgtgtg tctggccacc ggcttctatc ccgatcacgt ggaactgtct tggtgggtca     2400

acggcaaaga ggtgcacagc ggcgtcagca ccgatcctca gcctctgaaa gagcagcccg     2460

ctctgaacga cagcagatac tgcctgagca gcagactgag agtgtccgcc accttctggc     2520

agaaccccag aaaccacttc agatgccagg tgcagttcta cggcctgagc gagaacgatg     2580

agtggaccca ggatagagcc aagcctgtga cacagatcgt gtctgccgaa gcctggggca     2640

gagccgattg tggctttacc agcgagagct accagcaggg cgtgctgtct gccacaatcc     2700

tgtacgagat cctgctggga aaagccactc tgtacgctgt gctggtgtcc gctctggtgc     2760

tgatggccat ggtcaagcgg aaggatagca ggggcggctc cggtgccaca aacttctccc     2820

tgctcaagca ggccggagat gtggaagaga accctggccc tatgatcagc ctgagagtgc     2880

tgctggtcat cctgtggctg cagctgtctt gggtctggtc ccagcggaaa gaggtggaac     2940

aggaccccgg acctttcaat gtgcctgaag gcgccaccgt ggccttcaac tgcacctaca     3000

gcaatagcgc cagccagagc ttcttctggt acagacagga ctgccggaaa gaacccaagc     3060

tgctgatgag cgtgtacagc agcggcaacg aggacggcag attcacagcc cagctgaaca     3120

gagccagcca gtacatcagc ctgctgatcc gggatagcaa gctgagcgat agcgccacct     3180

acctgtgcgt ggtcaacctg ctgtctaatc aaggcggcaa gctgatcttc ggccagggca     3240

cagagctgag cgtgaagccc aacattcaga accccgatcc tgccgtgtac cagctgagag     3300

acagcaagag cagcgacaag agcgtgtgcc tgttcaccga cttcgacagc cagaccaacg     3360

tgtcccagag caaggacagc gacgtgtaca tcaccgataa gaccgtgctg gacatgcgga     3420

gcatggactt caagagcaac agcgccgtgg cctggtccaa caagagcgat ttcgcctgcg     3480

ccaacgcctt caacaacagc attatccccg aggacacatt cttcccaagt cctgagagca     3540

gctgcgacgt gaagctggtg gaaaagagct tcgagacaga caccaacctg aacttccaga     3600

acctgtccgt gatcggcttc cggatcctgc tgctgaaagt ggccggcttc aacctcctga     3660

tgaccctgag actgtggtcc agctaacctc gactgtgcct tctagttgcc agccatctgt     3720

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc     3780

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg     3840

tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga     3900

tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcta gggggtatcc     3960

ccactagtcg tgtaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc     4020

accgattttg attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca     4080

gacaaaactg tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg     4140

agcaacaaat ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac     4200

accttcttcc ccagcccagg taagggcagc tttggtgcct tcgcaggctg tttccttgct     4260

tcaggaatgg ccaggttctg cccagagctc tggtcaatga tgtctaaaac tcctctgatt     4320

ggtggtctcg gccttatcca ttgccaccaa aaccctcttt ttactaagaa acagtgagcc     4380

ttgttctggc agtccagaga atgacacggg aaaaaagcag atgaagagaa ggtggcagga     4440

gagggcacgt ggcccagcct cagtctctag atctaggaac ccctagtgat ggagttggcc     4500

actccctctc tgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg     4560

gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaag     4620

aattctctgg ccgtcgtttt acaacg                                          4646


<210>  630
<211>  3448
<212>  DNA
<213>  Homo sapiens

<400>  630
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgagggccg      660

cggcagcctg ctgacctgcg gcgacgtgga ggagaatccc ggccccatga gcaatcaagt      720

cctttgttgt gttgtcctgt gtttccttgg cgcaaatacc gtcgacggcg ggataactca      780

gtcccccaaa tacctcttca gaaaagaagg acaaaacgta acgctttcct gcgagcagaa      840

tcttaaccac gacgccatgt actggtacag gcaagaccct ggacaaggtc ttaggctcat      900

atactactct cagattgtca atgacttcca aaaaggggac atagctgagg gctactctgt      960

gtcccgagag aagaaggagt catttcccct gacagtgact tctgcacaaa aaaatcccac     1020

tgcattttat ttgtgtgcca gttcaccggg tgcattgtat gagcaatact ttggccccgg     1080

cactagactg acagttacgg aggatctgaa aaacgtcttc ccgccagagg tggcagtttt     1140

cgagcccagt gaggctgaaa tctctcatac ccaaaaagca acccttgtct gtctcgccac     1200

tggattctat cccgaccacg tcgaattgag ctggtgggtc aatgggaaag aggtacatag     1260

tggggtctgt acggatccac aaccccttaa ggaacaacct gcccttaacg attcacgata     1320

ctgcctgtca tcacgactca gggtatctgc taccttttgg cagaacccga gaaatcactt     1380

tcggtgccag gttcagtttt acggacttag cgaaaatgat gaatggacac aagaccgagc     1440

aaagcccgtt actcaaatag tgagcgcgga agcctggggg cgagcagact gcggcttcac     1500

ctccgaaagt taccagcaag gtgttttgtc agccaccatt ttgtatgaga ttttgttggg     1560

gaaggcgaca ctttacgcgg tactggtctc tgccttggtt cttatggcta tggtcaagag     1620

gaaagattcc aggggtggct ccggtgccac aaacttctcc ctgctcaagc aggccggaga     1680

tgtggaagag aaccctggcc ctatgacctc tatcagagct gtctttatat ttctctggct     1740

tcaacttgat ctggtgaatg gcgaaaacgt ggaacagcac ccttcaacgt tgagcgttca     1800

ggaaggagat tcagccgtca tcaagtgtac gtattccgat tccgcgtcaa actacttccc     1860

gtggtacaaa caggaacttg gcaagcgccc ccagctcatt atcgacatca gaagcaacgt     1920

aggagagaag aaggaccaac gcatagctgt gactctcaac aaaacagcta aacatttctc     1980

cctgcacatt acggaaaccc aaccagagga ttctgccgta tacttttgtg ctgctactga     2040

ggacctcact ttgatctggg gagcgggtac gaagctcata ataaaacccg atatccaaaa     2100

cccggaccca gcagtttatc aattgagaga tagtaagtcc agtgacaaat cagtttgttt     2160

gtttacggat ttcgatagcc agaccaatgt cagtcagtca aaggacagtg atgtatacat     2220

tacagataaa tgtgtacttg acatgcgctc aatggacttt aagtctaact ctgctgtagc     2280

ttggtctaac aaaagtgatt ttgcgtgtgc caacgcattt aacaacagca tcatacctga     2340

agacacgttc tttccgagtc cagaaagttc ctgtgacgtg aaacttgtag aaaagagttt     2400

cgagaccgac actaacctta actttcaaaa cctttcagtg atcggattta gaatcttgct     2460

gctcaaggtg gcagggttca atctgctgat gactctgcga ctgtggagtt cataacctcg     2520

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     2580

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     2640

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     2700

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggcttc tgaggcggaa     2760

agaaccagct ggggctctag ggggtatccc cactagtcgt gtaccagctg agagactcta     2820

aatccagtga caagtctgtc tgcctattca ccgattttga ttctcaaaca aatgtgtcac     2880

aaagtaagga ttctgatgtg tatatcacag acaaaactgt gctagacatg aggtctatgg     2940

acttcaagag caacagtgct gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg     3000

ccttcaacaa cagcattatt ccagaagaca ccttcttccc cagcccaggt aagggcagct     3060

ttggtgcctt cgcaggctgt ttccttgctt caggaatggc caggttctgc ccagagctct     3120

ggtcaatgat gtctaaaact cctctgattg gtggtctcgg ccttatccat tgccaccaaa     3180

accctctttt tactaagaaa cagtgagcct tgttctggca gtccagagaa tgacacggga     3240

aaaaagcaga tgaagagaag gtggcaggag agggcacgtg gcccagcctc agtctctaga     3300

tctaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     3360

aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg     3420

agcgagcgcg cagagaggga gtggccaa                                        3448


<210>  631
<211>  3478
<212>  DNA
<213>  Homo sapiens

<400>  631
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgagggccg      660

cggcagcctg ctgacctgcg gcgacgtgga ggagaatccc ggccccatgg gatgtagact      720

tctgtgttgc gccgtgctgt gtctgcttgg agctggcgaa ctggtgccta tggaaaccgg      780

cgtgacccag acacctagac acctggtcat gggcatgaca aacaagaaaa gcctgaagtg      840

cgagcagcac ctgggccaca atgccatgta ctggtacaag cagagcgcca agaaacccct      900

ggaactgatg ttcgtgtaca gcctggaaga gagggtcgag aacaacagcg tgcccagcag      960

attcagccct gagtgcccta atagcagcca cctgtttctg catctgcaca ccctgcagcc     1020

tgaggactct gccctgtatc tgtgtgccag cagccaggac tacctggtgt ccaacgagaa     1080

gctgttcttc ggcagcggca cacagctgag cgtgctggaa gatctgaaga acgtgttccc     1140

acctgaggtg gccgtgttcg agccttctga ggccgagatc agccacacac agaaagccac     1200

actcgtgtgt ctggccaccg gcttctatcc cgatcacgtg gaactgtctt ggtgggtcaa     1260

cggcaaagag gtgcacagcg gcgtcagcac cgatcctcag cctctgaaag agcagcccgc     1320

tctgaacgac agcagatact gcctgagcag cagactgaga gtgtccgcca ccttctggca     1380

gaaccccaga aaccacttca gatgccaggt gcagttctac ggcctgagcg agaacgatga     1440

gtggacccag gatagagcca agcctgtgac acagatcgtg tctgccgaag cctggggcag     1500

agccgattgt ggctttacca gcgagagcta ccagcagggc gtgctgtctg ccacaatcct     1560

gtacgagatc ctgctgggaa aagccactct gtacgctgtg ctggtgtccg ctctggtgct     1620

gatggccatg gtcaagcgga aggatagcag gggcggctcc ggtgccacaa acttctccct     1680

gctcaagcag gccggagatg tggaagagaa ccctggccct atgatcagcc tgagagtgct     1740

gctggtcatc ctgtggctgc agctgtcttg ggtctggtcc cagcggaaag aggtggaaca     1800

ggaccccgga cctttcaatg tgcctgaagg cgccaccgtg gccttcaact gcacctacag     1860

caatagcgcc agccagagct tcttctggta cagacaggac tgccggaaag aacccaagct     1920

gctgatgagc gtgtacagca gcggcaacga ggacggcaga ttcacagccc agctgaacag     1980

agccagccag tacatcagcc tgctgatccg ggatagcaag ctgagcgata gcgccaccta     2040

cctgtgcgtg gtcaacctgc tgtctaatca aggcggcaag ctgatcttcg gccagggcac     2100

agagctgagc gtgaagccca acattcagaa ccccgatcct gccgtgtacc agctgagaga     2160

cagcaagagc agcgacaaga gcgtgtgcct gttcaccgac ttcgacagcc agaccaacgt     2220

gtcccagagc aaggacagcg acgtgtacat caccgataag accgtgctgg acatgcggag     2280

catggacttc aagagcaaca gcgccgtggc ctggtccaac aagagcgatt tcgcctgcgc     2340

caacgccttc aacaacagca ttatccccga ggacacattc ttcccaagtc ctgagagcag     2400

ctgcgacgtg aagctggtgg aaaagagctt cgagacagac accaacctga acttccagaa     2460

cctgtccgtg atcggcttcc ggatcctgct gctgaaagtg gccggcttca acctcctgat     2520

gaccctgaga ctgtggtcca gctaacctcg actgtgcctt ctagttgcca gccatctgtt     2580

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     2640

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     2700

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     2760

gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctctag ggggtatccc     2820

cactagtcgt gtaccagctg agagactcta aatccagtga caagtctgtc tgcctattca     2880

ccgattttga ttctcaaaca aatgtgtcac aaagtaagga ttctgatgtg tatatcacag     2940

acaaaactgt gctagacatg aggtctatgg acttcaagag caacagtgct gtggcctgga     3000

gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa cagcattatt ccagaagaca     3060

ccttcttccc cagcccaggt aagggcagct ttggtgcctt cgcaggctgt ttccttgctt     3120

caggaatggc caggttctgc ccagagctct ggtcaatgat gtctaaaact cctctgattg     3180

gtggtctcgg ccttatccat tgccaccaaa accctctttt tactaagaaa cagtgagcct     3240

tgttctggca gtccagagaa tgacacggga aaaaagcaga tgaagagaag gtggcaggag     3300

agggcacgtg gcccagcctc agtctctaga tctaggaacc cctagtgatg gagttggcca     3360

ctccctctct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg     3420

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaa       3478


<210>  632
<211>  3466
<212>  DNA
<213>  Homo sapiens

<400>  632
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgagggccg      660

cggcagcctg ctgacctgcg gcgacgtgga ggagaatccc ggccccatgg gatcttggac      720

actgtgttgc gtgtccctgt gcatcctggt ggccaagcac acagatgccg gcgtgatcca      780

gtctcctaga cacgaagtga ccgagatggg ccaagaagtg accctgcgct gcaagcctat      840

cagcggccac gattacctgt tctggtacag acagaccatg atgagaggcc tggaactgct      900

gatctacttc aacaacaacg tgcccatcga cgacagcggc atgcccgagg atagattcag      960

cgccaagatg cccaacgcca gcttcagcac cctgaagatc cagcctagcg agcccagaga     1020

tagcgccgtg tacttctgcg ccagcagaaa gacaggcggc tacagcaatc agccccagca     1080

ctttggagat ggcacccggc tgagcatcct ggaagatctg aagaacgtgt tcccacctga     1140

ggtggccgtg ttcgagcctt ctgaggccga gatcagccac acacagaaag ccacactcgt     1200

gtgtctggcc accggcttct atcccgatca cgtggaactg tcttggtggg tcaacggcaa     1260

agaggtgcac agcggcgtca gcaccgatcc tcagcctctg aaagagcagc ccgctctgaa     1320

cgacagcaga tactgcctga gcagcagact gagagtgtcc gccaccttct ggcagaaccc     1380

cagaaaccac ttcagatgcc aggtgcagtt ctacggcctg agcgagaacg atgagtggac     1440

ccaggataga gccaagcctg tgacacagat cgtgtctgcc gaagcctggg gcagagccga     1500

ttgtggcttt accagcgaga gctaccagca gggcgtgctg tctgccacaa tcctgtacga     1560

gatcctgctg ggcaaagcca ctctgtacgc cgtgctggtg tctgccctgg tgctgatggc     1620

catggtcaag cggaaggata gcaggggcgg ctccggtgcc acaaacttct ccctgctcaa     1680

gcaggccgga gatgtggaag agaaccctgg ccctatggaa accctgctga aggtgctgag     1740

cggcacactg ctgtggcagc tgacatgggt ccgatctcag cagcctgtgc agtctcctca     1800

ggccgtgatt ctgagagaag gcgaggacgc cgtgatcaac tgcagcagct ctaaggccct     1860

gtacagcgtg cactggtaca gacagaagca cggcgaggcc cctgtgttcc tgatgatcct     1920

gctgaaaggc ggcgagcaga agggccacga gaagatcagc gccagcttca acgagaagaa     1980

gcagcagtcc agcctgtacc tgacagccag ccagctgagc tacagcggca cctacttttg     2040

tggcaccgcc tggatcaacg actacaagct gtctttcgga gccggcacca cagtgacagt     2100

gcgggccaat attcagaacc ccgatcctgc cgtgtaccag ctgagagaca gcaagagcag     2160

cgacaagagc gtgtgcctgt tcaccgactt cgacagccag accaacgtgt cccagagcaa     2220

ggacagcgac gtgtacatca ccgataagac tgtgctggac atgcggagca tggacttcaa     2280

gagcaacagc gccgtggcct ggtccaacaa gagcgatttc gcctgcgcca acgccttcaa     2340

caacagcatt atccccgagg acacattctt cccaagtcct gagagcagct gcgacgtgaa     2400

gctggtggaa aagagcttcg agacagacac caacctgaac ttccagaacc tgagcgtgat     2460

cggcttcaga atcctgctgc tcaaggtggc cggcttcaac ctgctgatga ccctgagact     2520

gtggtccagc taacctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     2580

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     2640

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     2700

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct     2760

atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca ctagtcgtgt     2820

accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc gattttgatt     2880

ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac aaaactgtgc     2940

tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc aacaaatctg     3000

actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc ttcttcccca     3060

gcccaggtaa gggcagcttt ggtgccttcg caggctgttt ccttgcttca ggaatggcca     3120

ggttctgccc agagctctgg tcaatgatgt ctaaaactcc tctgattggt ggtctcggcc     3180

ttatccattg ccaccaaaac cctcttttta ctaagaaaca gtgagccttg ttctggcagt     3240

ccagagaatg acacgggaaa aaagcagatg aagagaaggt ggcaggagag ggcacgtggc     3300

ccagcctcag tctctagatc taggaacccc tagtgatgga gttggccact ccctctctgc     3360

gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg acctttggtc     3420

gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaa                    3466


