                         SEQUENCE LISTING

<110>  The Brigham and Women's Hospital, Inc.
 
<120>  The long non-coding RNA INCA1 and Homo sapiens heterogeneous 
       nuclear ribonucleoprotein H1 (HNRNPH1) as therapeutic targets for
        immunotherapy

<130>  29618-0215WO1

<140>  PCT/US2019/056362
<141>  2019-10-15

<150>  62/745,554
<151>  2018-10-15

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  2032
<212>  DNA
<213>  Homo sapiens

<400>  1
gggctcggcc ggggagcgtg cggagtctgc acgccgcggc cgtcggtcca acgcggggag       60

gctcagggat tttcggcagc agcgacttca tccaccccgg accgccggct ggaggacgtg      120

cctgcagccg gcgggtacct gcggccaatt cggtggaacg aggacgcgga ctgcgaaggc      180

aggtaccctc ctctgaaatc aaaactcttt aattaaagag acatgaaatg acaagatttt      240

aaaaaaatcc catgaggaga aggcattcta atttaggaag aactccccct tggaaaaacc      300

atcagtgccg gaagatttcc tattgtgttg atccatggca aaggagactg cagatacaca      360

agggatatta tggagcccag acgacctgaa taaaaccctt ccctactaca aggacagctg      420

tcccttccct acacactccc tacaggctga tgagagacct tttttggaag cagaaactta      480

tactttatgc tgccttcttc ctgactgcca ggattatact cttcctttcc atcccagatc      540

tagcaatgct gttgatgagg ctaagtcatg atgatttctt taatatcttg gaacacagta      600

gatgcctgat atttgcggat ggactggaga aaaactgaaa gtataaacca caacatctca      660

agagatgtca tgaatggaga agcatatggt aaaatataat gaaaattaaa tctactttac      720

aagtggtatc ttcttgacaa tagtggcatt acctgagcca gtatcaggga ccagaaatac      780

aacataaaac tgatacattt ctcttaatcc ccacatgatt ttgtttttga gtttatagtt      840

atcagtgatc attgattaat aattgatcag tgatcagtga caaatgtata ctttttctac      900

ttgtattgtt agccctcaga ttgatggtag ttagcccagg aatggaaaga ccaaggggag      960

atgatttaat tctagtcaaa tattaaaagg tcatcatgta aatgaaataa tcccaagact     1020

acaactagag gggcagattt cagcttacta ttagggagta atttcaacag gatatggaag     1080

ggatatccaa atggcaggga ggccattgtg ggatatgaca gggacgccat tgcaggaaat     1140

ataagaacag aagatcctct gggggatttt tgttctttgt gggagtttgg attagctgct     1200

cctgcctggg atcctttcag ctctcaattc tgtgaaactc aacaatgaaa gcagaggtgt     1260

tttcctttac ttagctagtg ccaacacaaa actttgaact caagtgacct gataacataa     1320

ctgtgggtca ataccgagga actaacactc ctagttcctt ttcaattccc caagacaaca     1380

tcagtataga ttttcaagat gaatatatgc ccagtaagta tggcttatcc tgtactggaa     1440

gaataggttc tttcacactt aatgtgatta ttttttgtct tcatagggtg acttcaagtc     1500

ttttttaatg tgaaccttac agtggggttt gttctgaata tatttatttg catttgatat     1560

agagaggctc aaaaaaggaa aactgacgga cctaataaaa taaaaaaata gtagttgaat     1620

aaaaaaattt ctggagggac acacaaataa tggttactct ctctgcatgc catgggagat     1680

agtggtgaag ggaggaggga cacttttgca attcatttga tctcttccac agtatctgaa     1740

ttatttgcaa gtatacgtat tccatttgta ataaaaaagt aaagactaga aattcttttt     1800

ggaaaactgt acatactgta gaacatggct ctgtgttgtt tgtctctgga tttccagtga     1860

ctatcaaata ggtgctcaag aaattggata attatgtgaa tgaattcatg aattgaatga     1920

atgaatgaac agactatgct gttctgtttg aaaataagta tggacttaca agaatgaaaa     1980

gtcttcaaca cttggaatat gttttcaata aagatcaggc ctctcatcta ta             2032


<210>  2
<211>  2184
<212>  DNA
<213>  Homo sapiens

<400>  2
aagcccaaga ggctttccct aactccaaaa cggcgacctt taaagtaagg gagggttggg       60

gcaccacagc ggccggattt ctaattgtgg aaagtttaaa caaatttgtc cctcggggaa      120

tgggggaagg gagagaagaa caagtctggg ctcggccggg gagcgtgcgg agtctgcacg      180

ccgcggccgt cggtccaacg cggggaggct cagggatttt cggcagcagc gacttcatcc      240

accccggacc gccggctgga ggacgtgcct gcagccggcg ggtacctgcg gccaattcgg      300

tggaacgagg acgcggactg cgaaggcagg taccctcctc tgaaatcaaa actctttaat      360

taaagagaca tgaaatgaca agattttaaa aaaatcccat gaggagaagg cattctaatt      420

taggaagaac tcccccttgg aaaaaccatc agtgccggaa gatttcctat tgtgttgatc      480

catggcaaag gagactgcag atacacaagg gatattatgg agcccagacg acctgaataa      540

aacccttccc tactacaagg acagctgtcc cttccctaca cactccctac aggctgatga      600

gagacctttt ttggaagcag aaacttatac tttatgctgc cttcttcctg actgccagga      660

ttatactctt cctttccatc ccagatctag caatgctgtt gatgaggcta agtcatgatg      720

atttctttaa tatcttggaa cacagtagat gcctgatatt tgcggatgga ctggagaaaa      780

actgaaagta taaaccacaa catctcaaga gatgtcatga atggagaagc atatggtaaa      840

atataatgaa aattaaatct actttacaag tggtatcttc ttgacaatag tggcattacc      900

tgagccagta tcagggacca gaaatacaac ataaaactga tacatttctc ttaatcccca      960

catgattttg tttttgagtt tatagttatc agtgatcatt gattaataat tgatcagtga     1020

tcagtgacaa atgtatactt tttctacttg tattgttagc cctcagattg atggtagtta     1080

gcccaggaat ggaaagacca aggggagatg atttaattct agtcaaatat taaaaggtca     1140

tcatgtaaat gaaataatcc caagactaca actagagggg cagatttcag cttactatta     1200

gggagtaatt tcaacaggat atggaaggga tatccaaatg gcagggaggc cattgtggga     1260

tatgacaggg acgccattgc aggaaatata agaacagaag atcctctggg ggatttttgt     1320

tctttgtggg agtttggatt agctgctcct gcctgggatc ctttcagctc tcaattctgt     1380

gaaactcaac aatgaaagca gaggtgtttt cctttactta gctagtgcca acacaaaact     1440

ttgaactcaa gtgacctgat aacataactg tgggtcaata ccgaggaact aacactccta     1500

gttccttttc aattccccaa gacaacatca gtatagattt tcaagatgaa tatatgccca     1560

gtaagtatgg cttatcctgt actggaagaa taggttcttt cacacttaat gtgattattt     1620

tttgtcttca tagggtgact tcaagtcttt tttaatgtga accttacagt ggggtttgtt     1680

ctgaatatat ttatttgcat ttgatataga gaggctcaaa aaaggaaaac tgacggacct     1740

aataaaataa aaaaatagta gttgaataaa aaaatttctg gagggacaca caaataatgg     1800

ttactctctc tgcatgccat gggagatagt ggtgaaggga ggagggacac ttttgcaatt     1860

catttgatct cttccacagt atctgaatta tttgcaagta tacgtattcc atttgtaata     1920

aaaaagtaaa gactagaaat tctttttgga aaactgtaca tactgtagaa catggctctg     1980

tgttgtttgt ctctggattt ccagtgacta tcaaataggt gctcaagaaa ttggataatt     2040

atgtgaatga attcatgaat tgaatgaatg aatgaacaga ctatgctgtt ctgtttgaaa     2100

ataagtatgg acttacaaga atgaaaagtc ttcaacactt ggaatatgtt ttcaataaag     2160

atcaggcctc tcatctataa taat                                            2184


<210>  3
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  3
attaggtccg tcagt                                                        15


<210>  4
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  4
ttacatgatg accttt                                                       16


<210>  5
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  5
gccattgcag gaaatataag a                                                 21


<210>  6
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  CAGCTCTCAATTCTGTGAAACTCAA

<400>  6
cagctctcaa ttctgtgaaa ctcaa                                             25


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  7
gcgactatac gcgcaatatg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  8
ctccagctcc ccccggcaac                                                   20


<210>  9
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  9
aactttcgat ggtagtcgcc g                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  10
ccttggatgt ggtagccgtt t                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  11
gtgggatatg acagggacgc                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  12
ggcaggagca gctaatccaa                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  13
aagcccaaga ggctttccct                                                   20


<210>  14
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  14
attattatag atgagaggcc tgatc                                             25


<210>  15
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  15
gagtggtaag accaccacc                                                    19


<210>  16
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  16
ggttttcctc aggatctaat                                                   20


<210>  17
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  17
agtgctatct gaacctgtgg tc                                                22


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  18
agtgctgggt catccaaagg                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  19
ctccgcacgg accatgtatt                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  20
tcggactgaa cgtggaaagg                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  21
ccagagcagc atgagtggat                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  22
tagctgctgt tcactgctcc                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  23
agcagacaca cgtatgcgaa                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  24
gtggttccca atccccacat                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  25
gtcctgacga caacggacaa                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  26
agaatgaaga ccaaccgccc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  27
cacgtagaca ttccccgctt                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  28
ctgcctgcgt aactagaggg                                                   20


<210>  29
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  29
gtgcctgcag ccggcggg                                                     18


<210>  30
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  30
cttgcggccg ctaaccgtct ttcttctatt tcagactcct cc                          42


<210>  31
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  31
cggttagcgg ccgcaagcaa tgaagcatgc aggtctggg                              39


<210>  32
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  32
cttgtcattt catgtctctt taattaaaga g                                      31


<210>  33
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  33
ggttaagctt agatgcatgc tcgagcgg                                          28


<210>  34
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  34
taatacgact cactataggg tgggtctggc acgaagg                                37


<210>  35
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  35
tgtgacggac gcaactgg                                                     18


<210>  36
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  36
taatacgact cactatagga atacatggtc cgtgcgg                                37


<210>  37
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  37
cgcggcctga ggaagggg                                                     18


<210>  38
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  38
taatacgact cactataggc gggaggagcg cggaggc                                37


<210>  39
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  39
ccctagactc gccccacttg                                                   20


<210>  40

<400>  40
000

<210>  41
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  41
taatacgact cactataggg gacctaggca acggcct                                37


<210>  42
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  42
accggcagga gcttcatcac                                                   20


<210>  43
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  43
taatacgact cactataggc tttaatgccg gggtctg                                37


<210>  44
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  44
aagctaaata tggacctacg ct                                                22


<210>  45
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  45
taatacgact cactatagga gttttagaac tggaaggg                               38


<210>  46
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  46
tctttcttct atttcagact cctcc                                             25


<210>  47
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  47
taatacgact cactataggc aatgaagcat gcaggtctgg g                           41


<210>  48
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  48
ctgcaaaaga aaacaacaaa aaaactaaag                                        30


<210>  49
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  49
ctgggtggaa gttgggggtg ggacggcgcc gggaggccgg ggaggcagcg gcgaaaggcg       60

gcgggcgg                                                                68


<210>  50
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  50
attggcgggg tctcggtggg ggcgggccgg ttgccggggg gagctggagt cacgtgacgg       60

ccggcgcgg                                                               69


<210>  51
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  51
ccgctgtggc tgtggtgggc ggtaggggct tttaccgtgt gagctccttt aatgccgggg       60

tctgcagtg                                                               69


<210>  52
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  52
tgaatagaag gagggttgag gggatatggt gtggaatggg ggaaggagga gtctgaaata       60

gaagaaaga                                                               69


<210>  53
<211>  2240
<212>  DNA
<213>  Homo sapiens

<400>  53
catttcgtct tagccacgca gaagtcgcgt gtctaggtga gtcgcggtgg gtcctcgctt       60

gcagttcagc gaccacgttt gtttcgacgc cggaccgcgt aagagacgat gatgttgggc      120

acggaaggtg gagagggatt cgtggtgaag gtccggggct tgccctggtc ttgctcggcc      180

gatgaagtgc agaggttttt ttctgactgc aaaattcaaa atggggctca aggtattcgt      240

ttcatctaca ccagagaagg cagaccaagt ggcgaggctt ttgttgaact tgaatcagaa      300

gatgaagtca aattggccct gaaaaaagac agagaaacta tgggacacag atatgttgaa      360

gtattcaagt caaacaacgt tgaaatggat tgggtgttga agcatactgg tccaaatagt      420

cctgacacgg ccaatgatgg ctttgtacgg cttagaggac ttccctttgg atgtagcaag      480

gaagaaattg ttcagttctt ctcagggttg gaaatcgtgc caaatgggat aacattgccg      540

gtggacttcc aggggaggag tacgggggag gccttcgtgc agtttgcttc acaggaaata      600

gctgaaaagg ctctaaagaa acacaaggaa agaatagggc acaggtatat tgaaatcttt      660

aagagcagta gagctgaagt tagaactcat tatgatccac cacgaaagct tatggccatg      720

cagcggccag gtccttatga cagacctggg gctggtagag ggtataacag cattggcaga      780

ggagctggct ttgagaggat gaggcgtggt gcttatggtg gaggctatgg aggctatgat      840

gattacaatg gctataatga tggctatgga tttgggtcag atagatttgg aagagacctc      900

aattactgtt tttcaggaat gtctgatcac agatacgggg atggtggctc tactttccag      960

agcacaacag gacactgtgt acacatgcgg ggattacctt acagagctac tgagaatgac     1020

atttataatt ttttttcacc gctcaaccct gtgagagtac acattgaaat tggtcctgat     1080

ggcagagtaa ctggtgaagc agatgtcgag ttcgcaactc atgaagatgc tgtggcagct     1140

atgtcaaaag acaaagcaaa tatgcaacac agatatgtag aactcttctt gaattctaca     1200

gcaggagcaa gcggtggtgc ttacgaacac agatatgtag aactcttctt gaattctaca     1260

gcaggagcaa gcggtggtgc ttatggtagc caaatgatgg gaggcatggg cttgtcaaac     1320

cagtccagct acgggggccc agccagccag cagctgagtg ggggttacgg aggcggctac     1380

ggtggccaga gcagcatgag tggatacgac caagttttac aggaaaactc cagtgatttt     1440

caatcaaaca ttgcataggt aaccaaggag cagtgaacag cagctactac agtagtggaa     1500

gccgtgcatc tatgggcgtg aacggaatgg gagggttgtc tagcatgtcc agtatgagtg     1560

gtggatgggg aatgtaattg atcgatcctg atcactgact cttggtcaac cttttttttt     1620

tttttttttt tttctttaag aaaacttcag tttaacagtt tctgcaatac aagcttgtga     1680

tttatgctta ctctaagtgg aaatcaggat tgttatgaag acttaaggcc cagtattttt     1740

gaatacaata ctcatctagg atgtaacagt gaagctgagt aaactataac tgttaaactt     1800

aagttccagc ttttctcaag ttagttatag gatgtactta agcagtaagc gtatttaggt     1860

aaaagcagtt gaattatgtt aaatgttgcc ctttgccacg ttaaattgaa cactgttttg     1920

gatgcatgtt gaaagacatg cttttatttt tttgtaaaac aatataggag ctgtgtctac     1980

tattaaaagt gaaacatttt ggcatgtttg ttaattctag tttcatttaa taacctgtaa     2040

ggcacgtaag tttaagcttt tttttttttt aagttaatgg gaaaaatttg agacgcaata     2100

ccaatactta ggattttggt cttggtgttt gtatgaaatt ctgaggcctt gatttaaatc     2160

tttcattgta ttgtgatttc cttttaggta tattgcgcta agtgaaactt gtcaaataaa     2220

tcctcctttt aaaaactgca                                                 2240


<210>  54
<211>  38
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<400>  54
tttttttttt nggggctcgg ccggggagcg tgcggagt                               38


<210>  55
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  55
ttggaatatg ttttcaataa agatcaggcc tctcatctaa aaaaa                       45


<210>  56
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  56
aggcaggtac cc                                                           12


<210>  57
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  57
atttaggaag aa                                                           12


