<110>    ICM Co., Ltd

<120>    PHARMACEUTICAL COMPOSITION FOR TREATING RETINAL DISEASES
         COMPRISING Nkx3.2 AND FRAGMENTS THEREOF

<130>    PCB810117ICM

<160>    28

<170>    KoPatentIn 3.0

<210>    1
<211>    144
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    166-309 aa fragment of Nkx3.2


<400>    1
Gly Val Gly Pro Arg Gly Ala His Val Ser Ala Leu Cys Ser Gly Ala
  1               5                  10                  15 

Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val Ala Glu Glu Glu Glu
             20                  25                  30 

Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg Ser Arg Ala Ala Phe
         35                  40                  45 

Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg Phe Asn His Gln Arg
     50                  55                  60 

Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala Ala Ser Leu Lys Leu
 65                  70                  75                  80 

Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Thr
                 85                  90                  95 

Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala Ser Ala Pro Ala Ala
            100                 105                 110 

Lys Lys Val Ala Val Lys Val Leu Val Arg Asp Asp Gln Arg Gln Tyr
        115                 120                 125 

Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu Leu Pro Leu Gln Pro
    130                 135                 140 




<210>    2
<211>    432
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence encoding 166-309 aa fragment of Nkx3.2


<400>    2
ggtgttggcc ccagaggtgc acacgtgtcc gcgctgtgca gcggggccgg cggcgggggc         60

ggcagcgggc cggcaggcgt cgcggaggag gaggaggagc cggcggcgcc caagccacgc        120

aagaagcgct cgcgggccgc tttctcccac gcgcaggtct tcgagctgga gcgccgcttt        180

aaccaccagc gctacctgtc cgggcccgag cgcgcagacc tggccgcgtc gctgaagctc        240

accgagacgc aggtgaaaat ctggttccag aaccgtcgct acaagacaaa gcgccggcag        300

atggcagccg acctgctggc ctcggcgccc gccgccaaga aggtggccgt aaaggtgctg        360

gtgcgcgacg accagagaca atacctgccc ggcgaagtgc tgcggccacc ctcgcttctg        420

ccactgcagc cc                                                            432


<210>    3
<211>    43
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    123-165 aa fragment of Nkx3.2


<400>    3
Leu Ser Leu Gly Gln Pro Val Cys Glu Leu Ala Ala Ser Lys Asp Leu
  1               5                  10                  15 

Glu Glu Glu Ala Ala Gly Arg Ser Asp Ser Glu Met Ser Ala Ser Val
             20                  25                  30 

Ser Gly Asp Arg Ser Pro Arg Thr Glu Asp Asp
         35                  40            


<210>    4
<211>    129
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence encoding 123-165 aa fragment of Nkx3.2


<400>    4
ttgagcctcg gccagccggt ctgtgagctg gccgcttcca aagacctaga ggaggaagcc         60

gcgggccgga gcgacagcga gatgtccgcc agcgtctcag gcgaccgcag cccaaggacc        120

gaggacgac                                                                129


<210>    5
<211>    24
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    310-333 aa fragment of Nkx3.2


<400>    5
Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro Gly Trp Ala Leu Ser Thr
  1               5                  10                  15 

Cys Ala Ala Ala Ala Gly Thr Gln
             20                


<210>    6
<211>    72
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence encoding 310-333 aa fragment of Nkx3.2


<400>    6
tcctactatt acccgtacta ctgcctccca ggctgggcgc tctccacctg cgcagctgcc         60

gcaggcaccc ag                                                             72


<210>    7
<211>    333
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Nkx3.2


<400>    7
Met Ala Val Arg Gly Ala Asn Thr Leu Thr Ser Phe Ser Ile Gln Ala
  1               5                  10                  15 

Ile Leu Asn Lys Lys Glu Glu Arg Gly Gly Leu Ala Ala Pro Glu Gly
             20                  25                  30 

Arg Pro Ala Pro Gly Gly Thr Ala Ala Ser Val Ala Ala Ala Pro Ala
         35                  40                  45 

Val Cys Cys Trp Arg Leu Phe Gly Glu Arg Asp Ala Gly Ala Leu Gly
     50                  55                  60 

Gly Ala Glu Asp Ser Leu Leu Ala Ser Pro Ala Gly Thr Arg Thr Ala
 65                  70                  75                  80 

Ala Gly Arg Thr Ala Glu Ser Pro Glu Gly Trp Asp Ser Asp Ser Ala
                 85                  90                  95 

Leu Ser Glu Glu Asn Glu Ser Arg Arg Arg Cys Ala Asp Ala Arg Gly
            100                 105                 110 

Ala Ser Gly Ala Gly Leu Ala Gly Gly Ser Leu Ser Leu Gly Gln Pro
        115                 120                 125 

Val Cys Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu Ala Ala Gly
    130                 135                 140 

Arg Ser Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp Arg Ser Pro
145                 150                 155                 160 

Arg Thr Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser Ala
                165                 170                 175 

Leu Cys Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val
            180                 185                 190 

Ala Glu Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg
        195                 200                 205 

Ser Arg Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg
    210                 215                 220 

Phe Asn His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala
225                 230                 235                 240 

Ala Ser Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn
                245                 250                 255 

Arg Arg Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala
            260                 265                 270 

Ser Ala Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg Asp
        275                 280                 285 

Asp Gln Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu
    290                 295                 300 

Leu Pro Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro Gly
305                 310                 315                 320 

Trp Ala Leu Ser Thr Cys Ala Ala Ala Ala Gly Thr Gln
                325                 330            


<210>    8
<211>    1002
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Nkx3.2


<400>    8
atggctgtgc gcggcgccaa caccttgacg tccttctcca tccaggcgat cctcaacaag         60

aaagaggagc gcggcgggct ggccgcgcca gaggggcgcc cggcgcccgg gggcacagcg        120

gcatcggtgg ccgcggctcc cgctgtctgc tgttggcggc tctttgggga gagggacgcg        180

ggcgcgttgg ggggcgccga ggactctctg ctggcgtctc ctgccggtac cagaacagct        240

gcggggcgga ctgcggagag cccggaaggc tgggactcgg actccgcgct cagcgaggag        300

aacgagagca ggcggcgctg cgcggacgcg cggggggcca gcggggccgg ccttgcgggg        360

ggatccttga gcctcggcca gccggtctgt gagctggccg cttccaaaga cctagaggag        420

gaagccgcgg gccggagcga cagcgagatg tccgccagcg tctcaggcga ccgcagccca        480

aggaccgagg acgacggtgt tggccccaga ggtgcacacg tgtccgcgct gtgcagcggg        540

gccggcggcg ggggcggcag cgggccggca ggcgtcgcgg aggaggagga ggagccggcg        600

gcgcccaagc cacgcaagaa gcgctcgcgg gccgctttct cccacgcgca ggtcttcgag        660

ctggagcgcc gctttaacca ccagcgctac ctgtccgggc ccgagcgcgc agacctggcc        720

gcgtcgctga agctcaccga gacgcaggtg aaaatctggt tccagaaccg tcgctacaag        780

acaaagcgcc ggcagatggc agccgacctg ctggcctcgg cgcccgccgc caagaaggtg        840

gccgtaaagg tgctggtgcg cgacgaccag agacaatacc tgcccggcga agtgctgcgg        900

ccaccctcgc ttctgccact gcagccctcc tactattacc cgtactactg cctcccaggc        960

tgggcgctct ccacctgcgc agctgccgca ggcacccagt ga                          1002


<210>    9
<211>    320
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    1-320 aa fragment of Nkx3.2


<400>    9
Met Ala Val Arg Gly Ala Asn Thr Leu Thr Ser Phe Ser Ile Gln Ala
  1               5                  10                  15 

Ile Leu Asn Lys Lys Glu Glu Arg Gly Gly Leu Ala Ala Pro Glu Gly
             20                  25                  30 

Arg Pro Ala Pro Gly Gly Thr Ala Ala Ser Val Ala Ala Ala Pro Ala
         35                  40                  45 

Val Cys Cys Trp Arg Leu Phe Gly Glu Arg Asp Ala Gly Ala Leu Gly
     50                  55                  60 

Gly Ala Glu Asp Ser Leu Leu Ala Ser Pro Ala Gly Thr Arg Thr Ala
 65                  70                  75                  80 

Ala Gly Arg Thr Ala Glu Ser Pro Glu Gly Trp Asp Ser Asp Ser Ala
                 85                  90                  95 

Leu Ser Glu Glu Asn Glu Ser Arg Arg Arg Cys Ala Asp Ala Arg Gly
            100                 105                 110 

Ala Ser Gly Ala Gly Leu Ala Gly Gly Ser Leu Ser Leu Gly Gln Pro
        115                 120                 125 

Val Cys Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu Ala Ala Gly
    130                 135                 140 

Arg Ser Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp Arg Ser Pro
145                 150                 155                 160 

Arg Thr Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser Ala
                165                 170                 175 

Leu Cys Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val
            180                 185                 190 

Ala Glu Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg
        195                 200                 205 

Ser Arg Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg
    210                 215                 220 

Phe Asn His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala
225                 230                 235                 240 

Ala Ser Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn
                245                 250                 255 

Arg Arg Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala
            260                 265                 270 

Ser Ala Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg Asp
        275                 280                 285 

Asp Gln Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu
    290                 295                 300 

Leu Pro Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro Gly
305                 310                 315                 320


<210>    10
<211>    307
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    1-307 aa fragment of Nkx3.2


<400>    10
Met Ala Val Arg Gly Ala Asn Thr Leu Thr Ser Phe Ser Ile Gln Ala
  1               5                  10                  15 

Ile Leu Asn Lys Lys Glu Glu Arg Gly Gly Leu Ala Ala Pro Glu Gly
             20                  25                  30 

Arg Pro Ala Pro Gly Gly Thr Ala Ala Ser Val Ala Ala Ala Pro Ala
         35                  40                  45 

Val Cys Cys Trp Arg Leu Phe Gly Glu Arg Asp Ala Gly Ala Leu Gly
     50                  55                  60 

Gly Ala Glu Asp Ser Leu Leu Ala Ser Pro Ala Gly Thr Arg Thr Ala
 65                  70                  75                  80 

Ala Gly Arg Thr Ala Glu Ser Pro Glu Gly Trp Asp Ser Asp Ser Ala
                 85                  90                  95 

Leu Ser Glu Glu Asn Glu Ser Arg Arg Arg Cys Ala Asp Ala Arg Gly
            100                 105                 110 

Ala Ser Gly Ala Gly Leu Ala Gly Gly Ser Leu Ser Leu Gly Gln Pro
        115                 120                 125 

Val Cys Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu Ala Ala Gly
    130                 135                 140 

Arg Ser Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp Arg Ser Pro
145                 150                 155                 160 

Arg Thr Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser Ala
                165                 170                 175 

Leu Cys Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val
            180                 185                 190 

Ala Glu Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg
        195                 200                 205 

Ser Arg Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg
    210                 215                 220 

Phe Asn His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala
225                 230                 235                 240 

Ala Ser Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn
                245                 250                 255 

Arg Arg Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala
            260                 265                 270 

Ser Ala Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg Asp
        275                 280                 285 

Asp Gln Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu
    290                 295                 300 

Leu Pro Leu
305        


<210>    11
<211>    292
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    42-333 aa fragment of Nkx3.2


<400>    11
Ser Val Ala Ala Ala Pro Ala Val Cys Cys Trp Arg Leu Phe Gly Glu
  1               5                  10                  15 

Arg Asp Ala Gly Ala Leu Gly Gly Ala Glu Asp Ser Leu Leu Ala Ser
             20                  25                  30 

Pro Ala Gly Thr Arg Thr Ala Ala Gly Arg Thr Ala Glu Ser Pro Glu
         35                  40                  45 

Gly Trp Asp Ser Asp Ser Ala Leu Ser Glu Glu Asn Glu Ser Arg Arg
     50                  55                  60 

Arg Cys Ala Asp Ala Arg Gly Ala Ser Gly Ala Gly Leu Ala Gly Gly
 65                  70                  75                  80 

Ser Leu Ser Leu Gly Gln Pro Val Cys Glu Leu Ala Ala Ser Lys Asp
                 85                  90                  95 

Leu Glu Glu Glu Ala Ala Gly Arg Ser Asp Ser Glu Met Ser Ala Ser
            100                 105                 110 

Val Ser Gly Asp Arg Ser Pro Arg Thr Glu Asp Asp Gly Val Gly Pro
        115                 120                 125 

Arg Gly Ala His Val Ser Ala Leu Cys Ser Gly Ala Gly Gly Gly Gly
    130                 135                 140 

Gly Ser Gly Pro Ala Gly Val Ala Glu Glu Glu Glu Glu Pro Ala Ala
145                 150                 155                 160 

Pro Lys Pro Arg Lys Lys Arg Ser Arg Ala Ala Phe Ser His Ala Gln
                165                 170                 175 

Val Phe Glu Leu Glu Arg Arg Phe Asn His Gln Arg Tyr Leu Ser Gly
            180                 185                 190 

Pro Glu Arg Ala Asp Leu Ala Ala Ser Leu Lys Leu Thr Glu Thr Gln
        195                 200                 205 

Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Thr Lys Arg Arg Gln
    210                 215                 220 

Met Ala Ala Asp Leu Leu Ala Ser Ala Pro Ala Ala Lys Lys Val Ala
225                 230                 235                 240 

Val Lys Val Leu Val Arg Asp Asp Gln Arg Gln Tyr Leu Pro Gly Glu
                245                 250                 255 

Val Leu Arg Pro Pro Ser Leu Leu Pro Leu Gln Pro Ser Tyr Tyr Tyr
            260                 265                 270 

Pro Tyr Tyr Cys Leu Pro Gly Trp Ala Leu Ser Thr Cys Ala Ala Ala
        275                 280                 285 

Ala Gly Thr Gln
    290        


<210>    12
<211>    235
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    99-333 aa fragment of Nkx3.2


<400>    12
Glu Glu Asn Glu Ser Arg Arg Arg Cys Ala Asp Ala Arg Gly Ala Ser
  1               5                  10                  15 

Gly Ala Gly Leu Ala Gly Gly Ser Leu Ser Leu Gly Gln Pro Val Cys
             20                  25                  30 

Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu Ala Ala Gly Arg Ser
         35                  40                  45 

Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp Arg Ser Pro Arg Thr
     50                  55                  60 

Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser Ala Leu Cys
 65                  70                  75                  80 

Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val Ala Glu
                 85                  90                  95 

Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg Ser Arg
            100                 105                 110 

Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg Phe Asn
        115                 120                 125 

His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala Ala Ser
    130                 135                 140 

Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg
145                 150                 155                 160 

Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala Ser Ala
                165                 170                 175 

Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg Asp Asp Gln
            180                 185                 190 

Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu Leu Pro
        195                 200                 205 

Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro Gly Trp Ala
    210                 215                 220 

Leu Ser Thr Cys Ala Ala Ala Ala Gly Thr Gln
225                 230                 235


<210>    13
<211>    222
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    112-333 aa fragment of Nkx3.2


<400>    13
Gly Ala Ser Gly Ala Gly Leu Ala Gly Gly Ser Leu Ser Leu Gly Gln
  1               5                  10                  15 

Pro Val Cys Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu Ala Ala
             20                  25                  30 

Gly Arg Ser Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp Arg Ser
         35                  40                  45 

Pro Arg Thr Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser
     50                  55                  60 

Ala Leu Cys Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly
 65                  70                  75                  80 

Val Ala Glu Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys
                 85                  90                  95 

Arg Ser Arg Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg
            100                 105                 110 

Arg Phe Asn His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu
        115                 120                 125 

Ala Ala Ser Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln
    130                 135                 140 

Asn Arg Arg Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu
145                 150                 155                 160 

Ala Ser Ala Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg
                165                 170                 175 

Asp Asp Gln Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser
            180                 185                 190 

Leu Leu Pro Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro
        195                 200                 205 

Gly Trp Ala Leu Ser Thr Cys Ala Ala Ala Ala Gly Thr Gln
    210                 215                 220 




<210>    14
<211>    211
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    123-333 aa fragment of Nkx3.2


<400>    14
Leu Ser Leu Gly Gln Pro Val Cys Glu Leu Ala Ala Ser Lys Asp Leu
  1               5                  10                  15 

Glu Glu Glu Ala Ala Gly Arg Ser Asp Ser Glu Met Ser Ala Ser Val
             20                  25                  30 

Ser Gly Asp Arg Ser Pro Arg Thr Glu Asp Asp Gly Val Gly Pro Arg
         35                  40                  45 

Gly Ala His Val Ser Ala Leu Cys Ser Gly Ala Gly Gly Gly Gly Gly
     50                  55                  60 

Ser Gly Pro Ala Gly Val Ala Glu Glu Glu Glu Glu Pro Ala Ala Pro
 65                  70                  75                  80 

Lys Pro Arg Lys Lys Arg Ser Arg Ala Ala Phe Ser His Ala Gln Val
                 85                  90                  95 

Phe Glu Leu Glu Arg Arg Phe Asn His Gln Arg Tyr Leu Ser Gly Pro
            100                 105                 110 

Glu Arg Ala Asp Leu Ala Ala Ser Leu Lys Leu Thr Glu Thr Gln Val
        115                 120                 125 

Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Thr Lys Arg Arg Gln Met
    130                 135                 140 

Ala Ala Asp Leu Leu Ala Ser Ala Pro Ala Ala Lys Lys Val Ala Val
145                 150                 155                 160 

Lys Val Leu Val Arg Asp Asp Gln Arg Gln Tyr Leu Pro Gly Glu Val
                165                 170                 175 

Leu Arg Pro Pro Ser Leu Leu Pro Leu Gln Pro Ser Tyr Tyr Tyr Pro
            180                 185                 190 

Tyr Tyr Cys Leu Pro Gly Trp Ala Leu Ser Thr Cys Ala Ala Ala Ala
        195                 200                 205 

Gly Thr Gln
    210    


<210>    15
<211>    232
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    99-330 aa fragment of Nkx3.2


<400>    15
Glu Glu Asn Glu Ser Arg Arg Arg Cys Ala Asp Ala Arg Gly Ala Ser
  1               5                  10                  15 

Gly Ala Gly Leu Ala Gly Gly Ser Leu Ser Leu Gly Gln Pro Val Cys
             20                  25                  30 

Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu Ala Ala Gly Arg Ser
         35                  40                  45 

Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp Arg Ser Pro Arg Thr
     50                  55                  60 

Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser Ala Leu Cys
 65                  70                  75                  80 

Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val Ala Glu
                 85                  90                  95 

Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg Ser Arg
            100                 105                 110 

Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg Phe Asn
        115                 120                 125 

His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala Ala Ser
    130                 135                 140 

Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg
145                 150                 155                 160 

Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala Ser Ala
                165                 170                 175 

Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg Asp Asp Gln
            180                 185                 190 

Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu Leu Pro
        195                 200                 205 

Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro Gly Trp Ala
    210                 215                 220 

Leu Ser Thr Cys Ala Ala Ala Ala
225                 230        


<210>    16
<211>    229
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    99-327 aa fragment of Nkx3.2


<400>    16
Glu Glu Asn Glu Ser Arg Arg Arg Cys Ala Asp Ala Arg Gly Ala Ser
  1               5                  10                  15 

Gly Ala Gly Leu Ala Gly Gly Ser Leu Ser Leu Gly Gln Pro Val Cys
             20                  25                  30 

Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu Ala Ala Gly Arg Ser
         35                  40                  45 

Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp Arg Ser Pro Arg Thr
     50                  55                  60 

Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser Ala Leu Cys
 65                  70                  75                  80 

Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val Ala Glu
                 85                  90                  95 

Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg Ser Arg
            100                 105                 110 

Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg Phe Asn
        115                 120                 125 

His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala Ala Ser
    130                 135                 140 

Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg
145                 150                 155                 160 

Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala Ser Ala
                165                 170                 175 

Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg Asp Asp Gln
            180                 185                 190 

Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu Leu Pro
        195                 200                 205 

Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro Gly Trp Ala
    210                 215                 220 

Leu Ser Thr Cys Ala
225                


<210>    17
<211>    222
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    99-320 aa fragment of Nkx3.2


<400>    17
Glu Glu Asn Glu Ser Arg Arg Arg Cys Ala Asp Ala Arg Gly Ala Ser
  1               5                  10                  15 

Gly Ala Gly Leu Ala Gly Gly Ser Leu Ser Leu Gly Gln Pro Val Cys
             20                  25                  30 

Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu Ala Ala Gly Arg Ser
         35                  40                  45 

Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp Arg Ser Pro Arg Thr
     50                  55                  60 

Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser Ala Leu Cys
 65                  70                  75                  80 

Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val Ala Glu
                 85                  90                  95 

Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg Ser Arg
            100                 105                 110 

Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg Phe Asn
        115                 120                 125 

His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala Ala Ser
    130                 135                 140 

Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg
145                 150                 155                 160 

Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala Ser Ala
                165                 170                 175 

Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg Asp Asp Gln
            180                 185                 190 

Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu Leu Pro
        195                 200                 205 

Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro Gly
    210                 215                 220 




<210>    18
<211>    223
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    105-327 aa fragment of Nkx3.2


<400>    18
Arg Arg Cys Ala Asp Ala Arg Gly Ala Ser Gly Ala Gly Leu Ala Gly
  1               5                  10                  15 

Gly Ser Leu Ser Leu Gly Gln Pro Val Cys Glu Leu Ala Ala Ser Lys
             20                  25                  30 

Asp Leu Glu Glu Glu Ala Ala Gly Arg Ser Asp Ser Glu Met Ser Ala
         35                  40                  45 

Ser Val Ser Gly Asp Arg Ser Pro Arg Thr Glu Asp Asp Gly Val Gly
     50                  55                  60 

Pro Arg Gly Ala His Val Ser Ala Leu Cys Ser Gly Ala Gly Gly Gly
 65                  70                  75                  80 

Gly Gly Ser Gly Pro Ala Gly Val Ala Glu Glu Glu Glu Glu Pro Ala
                 85                  90                  95 

Ala Pro Lys Pro Arg Lys Lys Arg Ser Arg Ala Ala Phe Ser His Ala
            100                 105                 110 

Gln Val Phe Glu Leu Glu Arg Arg Phe Asn His Gln Arg Tyr Leu Ser
        115                 120                 125 

Gly Pro Glu Arg Ala Asp Leu Ala Ala Ser Leu Lys Leu Thr Glu Thr
    130                 135                 140 

Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Thr Lys Arg Arg
145                 150                 155                 160 

Gln Met Ala Ala Asp Leu Leu Ala Ser Ala Pro Ala Ala Lys Lys Val
                165                 170                 175 

Ala Val Lys Val Leu Val Arg Asp Asp Gln Arg Gln Tyr Leu Pro Gly
            180                 185                 190 

Glu Val Leu Arg Pro Pro Ser Leu Leu Pro Leu Gln Pro Ser Tyr Tyr
        195                 200                 205 

Tyr Pro Tyr Tyr Cys Leu Pro Gly Trp Ala Leu Ser Thr Cys Ala
    210                 215                 220 




<210>    19
<211>    215
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    110-324 aa fragment of Nkx3.2


<400>    19
Ala Arg Gly Ala Ser Gly Ala Gly Leu Ala Gly Gly Ser Leu Ser Leu
  1               5                  10                  15 

Gly Gln Pro Val Cys Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu
             20                  25                  30 

Ala Ala Gly Arg Ser Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp
         35                  40                  45 

Arg Ser Pro Arg Thr Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His
     50                  55                  60 

Val Ser Ala Leu Cys Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro
 65                  70                  75                  80 

Ala Gly Val Ala Glu Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg
                 85                  90                  95 

Lys Lys Arg Ser Arg Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu
            100                 105                 110 

Glu Arg Arg Phe Asn His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala
        115                 120                 125 

Asp Leu Ala Ala Ser Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp
    130                 135                 140 

Phe Gln Asn Arg Arg Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp
145                 150                 155                 160 

Leu Leu Ala Ser Ala Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu
                165                 170                 175 

Val Arg Asp Asp Gln Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro
            180                 185                 190 

Pro Ser Leu Leu Pro Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr Tyr Cys
        195                 200                 205 

Leu Pro Gly Trp Ala Leu Ser
    210                 215


<210>    20
<211>    209
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    112-320 aa fragment of Nkx3.2


<400>    20
Gly Ala Ser Gly Ala Gly Leu Ala Gly Gly Ser Leu Ser Leu Gly Gln
  1               5                  10                  15 

Pro Val Cys Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu Ala Ala
             20                  25                  30 

Gly Arg Ser Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp Arg Ser
         35                  40                  45 

Pro Arg Thr Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser
     50                  55                  60 

Ala Leu Cys Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly
 65                  70                  75                  80 

Val Ala Glu Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys
                 85                  90                  95 

Arg Ser Arg Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg
            100                 105                 110 

Arg Phe Asn His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu
        115                 120                 125 

Ala Ala Ser Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln
    130                 135                 140 

Asn Arg Arg Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu
145                 150                 155                 160 

Ala Ser Ala Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg
                165                 170                 175 

Asp Asp Gln Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser
            180                 185                 190 

Leu Leu Pro Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro
        195                 200                 205 

Gly
   


<210>    21
<211>    198
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    123-320 aa fragment of Nkx3.2


<400>    21
Leu Ser Leu Gly Gln Pro Val Cys Glu Leu Ala Ala Ser Lys Asp Leu
  1               5                  10                  15 

Glu Glu Glu Ala Ala Gly Arg Ser Asp Ser Glu Met Ser Ala Ser Val
             20                  25                  30 

Ser Gly Asp Arg Ser Pro Arg Thr Glu Asp Asp Gly Val Gly Pro Arg
         35                  40                  45 

Gly Ala His Val Ser Ala Leu Cys Ser Gly Ala Gly Gly Gly Gly Gly
     50                  55                  60 

Ser Gly Pro Ala Gly Val Ala Glu Glu Glu Glu Glu Pro Ala Ala Pro
 65                  70                  75                  80 

Lys Pro Arg Lys Lys Arg Ser Arg Ala Ala Phe Ser His Ala Gln Val
                 85                  90                  95 

Phe Glu Leu Glu Arg Arg Phe Asn His Gln Arg Tyr Leu Ser Gly Pro
            100                 105                 110 

Glu Arg Ala Asp Leu Ala Ala Ser Leu Lys Leu Thr Glu Thr Gln Val
        115                 120                 125 

Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Thr Lys Arg Arg Gln Met
    130                 135                 140 

Ala Ala Asp Leu Leu Ala Ser Ala Pro Ala Ala Lys Lys Val Ala Val
145                 150                 155                 160 

Lys Val Leu Val Arg Asp Asp Gln Arg Gln Tyr Leu Pro Gly Glu Val
                165                 170                 175 

Leu Arg Pro Pro Ser Leu Leu Pro Leu Gln Pro Ser Tyr Tyr Tyr Pro
            180                 185                 190 

Tyr Tyr Cys Leu Pro Gly
        195            


<210>    22
<211>    191
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    130-320 aa fragment of Nkx3.2


<400>    22
Cys Glu Leu Ala Ala Ser Lys Asp Leu Glu Glu Glu Ala Ala Gly Arg
  1               5                  10                  15 

Ser Asp Ser Glu Met Ser Ala Ser Val Ser Gly Asp Arg Ser Pro Arg
             20                  25                  30 

Thr Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser Ala Leu
         35                  40                  45 

Cys Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val Ala
     50                  55                  60 

Glu Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg Ser
 65                  70                  75                  80 

Arg Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg Phe
                 85                  90                  95 

Asn His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala Ala
            100                 105                 110 

Ser Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg
        115                 120                 125 

Arg Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala Ser
    130                 135                 140 

Ala Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg Asp Asp
145                 150                 155                 160 

Gln Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu Leu
                165                 170                 175 

Pro Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro Gly
            180                 185                 190 




<210>    23
<211>    171
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    150-320 aa fragment of Nkx3.2


<400>    23
Met Ser Ala Ser Val Ser Gly Asp Arg Ser Pro Arg Thr Glu Asp Asp
  1               5                  10                  15 

Gly Val Gly Pro Arg Gly Ala His Val Ser Ala Leu Cys Ser Gly Ala
             20                  25                  30 

Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val Ala Glu Glu Glu Glu
         35                  40                  45 

Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg Ser Arg Ala Ala Phe
     50                  55                  60 

Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg Phe Asn His Gln Arg
 65                  70                  75                  80 

Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala Ala Ser Leu Lys Leu
                 85                  90                  95 

Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Thr
            100                 105                 110 

Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala Ser Ala Pro Ala Ala
        115                 120                 125 

Lys Lys Val Ala Val Lys Val Leu Val Arg Asp Asp Gln Arg Gln Tyr
    130                 135                 140 

Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu Leu Pro Leu Gln Pro
145                 150                 155                 160 

Ser Tyr Tyr Tyr Pro Tyr Tyr Cys Leu Pro Gly
                165                 170    


<210>    24
<211>    166
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    153-318 aa fragment of Nkx3.2


<400>    24
Ser Val Ser Gly Asp Arg Ser Pro Arg Thr Glu Asp Asp Gly Val Gly
  1               5                  10                  15 

Pro Arg Gly Ala His Val Ser Ala Leu Cys Ser Gly Ala Gly Gly Gly
             20                  25                  30 

Gly Gly Ser Gly Pro Ala Gly Val Ala Glu Glu Glu Glu Glu Pro Ala
         35                  40                  45 

Ala Pro Lys Pro Arg Lys Lys Arg Ser Arg Ala Ala Phe Ser His Ala
     50                  55                  60 

Gln Val Phe Glu Leu Glu Arg Arg Phe Asn His Gln Arg Tyr Leu Ser
 65                  70                  75                  80 

Gly Pro Glu Arg Ala Asp Leu Ala Ala Ser Leu Lys Leu Thr Glu Thr
                 85                  90                  95 

Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Thr Lys Arg Arg
            100                 105                 110 

Gln Met Ala Ala Asp Leu Leu Ala Ser Ala Pro Ala Ala Lys Lys Val
        115                 120                 125 

Ala Val Lys Val Leu Val Arg Asp Asp Gln Arg Gln Tyr Leu Pro Gly
    130                 135                 140 

Glu Val Leu Arg Pro Pro Ser Leu Leu Pro Leu Gln Pro Ser Tyr Tyr
145                 150                 155                 160 

Tyr Pro Tyr Tyr Cys Leu
                165    


<210>    25
<211>    161
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    156-316 aa fragment of Nkx3.2


<400>    25
Gly Asp Arg Ser Pro Arg Thr Glu Asp Asp Gly Val Gly Pro Arg Gly
  1               5                  10                  15 

Ala His Val Ser Ala Leu Cys Ser Gly Ala Gly Gly Gly Gly Gly Ser
             20                  25                  30 

Gly Pro Ala Gly Val Ala Glu Glu Glu Glu Glu Pro Ala Ala Pro Lys
         35                  40                  45 

Pro Arg Lys Lys Arg Ser Arg Ala Ala Phe Ser His Ala Gln Val Phe
     50                  55                  60 

Glu Leu Glu Arg Arg Phe Asn His Gln Arg Tyr Leu Ser Gly Pro Glu
 65                  70                  75                  80 

Arg Ala Asp Leu Ala Ala Ser Leu Lys Leu Thr Glu Thr Gln Val Lys
                 85                  90                  95 

Ile Trp Phe Gln Asn Arg Arg Tyr Lys Thr Lys Arg Arg Gln Met Ala
            100                 105                 110 

Ala Asp Leu Leu Ala Ser Ala Pro Ala Ala Lys Lys Val Ala Val Lys
        115                 120                 125 

Val Leu Val Arg Asp Asp Gln Arg Gln Tyr Leu Pro Gly Glu Val Leu
    130                 135                 140 

Arg Pro Pro Ser Leu Leu Pro Leu Gln Pro Ser Tyr Tyr Tyr Pro Tyr
145                 150                 155                 160 

Tyr
   


<210>    26
<211>    156
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    159-314 aa fragment of Nkx3.2


<400>    26
Ser Pro Arg Thr Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val
  1               5                  10                  15 

Ser Ala Leu Cys Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala
             20                  25                  30 

Gly Val Ala Glu Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys
         35                  40                  45 

Lys Arg Ser Arg Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu
     50                  55                  60 

Arg Arg Phe Asn His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp
 65                  70                  75                  80 

Leu Ala Ala Ser Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe
                 85                  90                  95 

Gln Asn Arg Arg Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu
            100                 105                 110 

Leu Ala Ser Ala Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val
        115                 120                 125 

Arg Asp Asp Gln Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro
    130                 135                 140 

Ser Leu Leu Pro Leu Gln Pro Ser Tyr Tyr Tyr Pro
145                 150                 155    


<210>    27
<211>    151
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    162-312 polypeptide fragment of Nkx3.2


<400>    27
Thr Glu Asp Asp Gly Val Gly Pro Arg Gly Ala His Val Ser Ala Leu
  1               5                  10                  15 

Cys Ser Gly Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val Ala
             20                  25                  30 

Glu Glu Glu Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg Ser
         35                  40                  45 

Arg Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg Phe
     50                  55                  60 

Asn His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala Ala
 65                  70                  75                  80 

Ser Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg
                 85                  90                  95 

Arg Tyr Lys Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala Ser
            100                 105                 110 

Ala Pro Ala Ala Lys Lys Val Ala Val Lys Val Leu Val Arg Asp Asp
        115                 120                 125 

Gln Arg Gln Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu Leu
    130                 135                 140 

Pro Leu Gln Pro Ser Tyr Tyr
145                 150    


<210>    28
<211>    146
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    165-310 polypeptide fragment of Nkx3.2


<400>    28
Asp Gly Val Gly Pro Arg Gly Ala His Val Ser Ala Leu Cys Ser Gly
  1               5                  10                  15 

Ala Gly Gly Gly Gly Gly Ser Gly Pro Ala Gly Val Ala Glu Glu Glu
             20                  25                  30 

Glu Glu Pro Ala Ala Pro Lys Pro Arg Lys Lys Arg Ser Arg Ala Ala
         35                  40                  45 

Phe Ser His Ala Gln Val Phe Glu Leu Glu Arg Arg Phe Asn His Gln
     50                  55                  60 

Arg Tyr Leu Ser Gly Pro Glu Arg Ala Asp Leu Ala Ala Ser Leu Lys
 65                  70                  75                  80 

Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys
                 85                  90                  95 

Thr Lys Arg Arg Gln Met Ala Ala Asp Leu Leu Ala Ser Ala Pro Ala
            100                 105                 110 

Ala Lys Lys Val Ala Val Lys Val Leu Val Arg Asp Asp Gln Arg Gln
        115                 120                 125 

Tyr Leu Pro Gly Glu Val Leu Arg Pro Pro Ser Leu Leu Pro Leu Gln
    130                 135                 140 

Pro Ser
145    
