                         SEQUENCE LISTING

<110>  NousCom AG
 
<120>  Teleost invariant chain cancer vaccine

<130>  854-21 PCT

<150>  EP18201541.2
<151>  2018-10-19

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is G or N

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is H or N

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is G or N

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is N or Q

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is E or A

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Q or E

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is L or M

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is K or R

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is A or V

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is S or A

<400>  1

Asn Gln Arg Xaa Asp Ile Lys Ser Leu Glu Glu Gln Xaa Ser Xaa Leu 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Thr Xaa Gly Arg Ser Xaa Xaa 
            20                  25          


<210>  2
<211>  187
<212>  PRT
<213>  Paralichthys olivaceus

<400>  2

Met Ser Glu Thr Gln Thr Leu Leu Gly Ala Pro Arg Gln Gln Thr Ala 
1               5                   10                  15      


Val Asp Val Gly Ala Pro Ala Gln Gly Gly Arg Ser Ala Asn Ala Tyr 
            20                  25                  30          


Lys Val Val Gly Leu Thr Val Leu Ala Cys Val Leu Val Met Ser Gln 
        35                  40                  45              


Ala Met Ile Ile Tyr Phe Leu Val Asn Gln Arg Gly Asp Ile Lys Ser 
    50                  55                  60                  


Leu Glu Glu Gln His Ser Gly Leu Asn Glu Gln Leu Thr Lys Gly Arg 
65                  70                  75                  80  


Ser Ala Ser Met Ser Met Gln Leu Pro Ser Ser Phe His Ser Leu Thr 
                85                  90                  95      


Phe Asp Glu Lys Ser Ser Thr Arg Ala Pro Glu Glu Thr Gly Pro Pro 
            100                 105                 110         


Gln Ala Thr Gln Cys Gln Leu Glu Ala Ala Gly Glu Lys Pro Val Gln 
        115                 120                 125             


Val Pro Gly Leu Arg Pro Asp Cys Asp Glu Arg Gly Leu Tyr Arg Leu 
    130                 135                 140                 


Lys Gln Cys Leu Lys His Arg Cys Trp Cys Val Asn Pro Ala Asn Gly 
145                 150                 155                 160 


Glu Gln Ile Pro Gly Ser Leu Gly Lys Glu Asp Val Thr Cys Asn Lys 
                165                 170                 175     


Gly Val His Ser Val Gly Leu Asp Lys Val Leu 
            180                 185         


<210>  3
<211>  27
<212>  PRT
<213>  Paralichthys olivaceus

<400>  3

Asn Gln Arg Gly Asp Ile Lys Ser Leu Glu Glu Gln His Ser Gly Leu 
1               5                   10                  15      


Asn Glu Gln Leu Thr Lys Gly Arg Ser Ala Ser 
            20                  25          


<210>  4
<211>  16
<212>  PRT
<213>  Paralichthys olivaceus

<400>  4

Asp Ile Lys Ser Leu Glu Glu Gln His Ser Gly Leu Asn Glu Gln Leu 
1               5                   10                  15      


<210>  5
<211>  196
<212>  PRT
<213>  Larimichthys crocea

<400>  5

Met Ser Asp Pro Glu Thr Pro Asn Gln Pro Leu Leu Gln Ala Ala Thr 
1               5                   10                  15      


Asn Val Pro Ala Ala Gln Arg Gly Ser Ser Ser Arg Ala Tyr Lys Val 
            20                  25                  30          


Ala Gly Phe Thr Leu Leu Ala Cys Leu Leu Ile Ala Gly Gln Ala Met 
        35                  40                  45              


Ile Ala Tyr Phe Leu Leu Asn Gln Arg Asn Asp Ile Lys Ser Leu Glu 
    50                  55                  60                  


Glu Gln Asn Ser Asn Leu Gln Ala Glu Met Thr Arg Gly Arg Ser Val 
65                  70                  75                  80  


Ala Val Pro Met Arg Thr His Met Ala Met Asn Ala Leu Pro Val Met 
                85                  90                  95      


Asp Val Ser Met Asp Glu Asp Ser Ser Ile Thr Asp Pro Glu Lys Pro 
            100                 105                 110         


Ala Pro Arg Gln Val Thr Asp Cys Gln Leu Glu Ala Ala Gly Lys Lys 
        115                 120                 125             


Pro Val Gln Val Pro Gly Phe Arg Pro Ser Cys Asp Glu Arg Gly Leu 
    130                 135                 140                 


Tyr Gln Pro Gln Gln Cys Phe Met Thr Gln Cys Trp Cys Val Asn Pro 
145                 150                 155                 160 


Ala Asn Gly Lys Gln Ile Pro Gly Ser Leu Lys Asn Gly Gln Ala Ser 
                165                 170                 175     


Cys Arg Ala Ala Val Ile Ala Val Ser Arg Ile Glu Tyr Ile Cys Thr 
            180                 185                 190         


Asp Val Gln Glu 
        195     


<210>  6
<211>  27
<212>  PRT
<213>  Larimichthys crocea

<400>  6

Asn Gln Arg Asn Asp Ile Lys Ser Leu Glu Glu Gln Asn Ser Asn Leu 
1               5                   10                  15      


Gln Ala Glu Met Thr Arg Gly Arg Ser Val Ala 
            20                  25          


<210>  7
<211>  16
<212>  PRT
<213>  Larimichthys crocea

<400>  7

Asp Ile Lys Ser Leu Glu Glu Gln Asn Ser Asn Leu Gln Ala Glu Met 
1               5                   10                  15      


<210>  8
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is G or D

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is T or A

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is T or S

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L or M

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is M or V

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is G or S

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Q or L

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is P or S

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is E or V

<400>  8

Asp Gln Lys Gln Gln Ile Gln Xaa Leu Gln Xaa Xaa Asn Gln Arg Xaa 
1               5                   10                  15      


Glu Lys Gln Xaa Xaa Xaa Arg Xaa Arg Xaa Ser 
            20                  25          


<210>  9
<211>  197
<212>  PRT
<213>  Boleophthalmus pectiniros

<400>  9

Met Glu His Ala Ser Glu Asp Ala Pro Leu Ala Arg Asp Ser Gly Thr 
1               5                   10                  15      


Gly Ser Glu Gln Ala Leu Val Val Pro Thr Ala Pro Arg Arg Gly Ser 
            20                  25                  30          


Asn Ser His Ala Val Lys Ile Ala Gly Ile Thr Thr Leu Val Cys Leu 
        35                  40                  45              


Leu Val Ser Ala Gln Val Phe Thr Ala Tyr Met Val Phe Asp Gln Lys 
    50                  55                  60                  


Gln Gln Ile Gln Gly Leu Gln Thr Ser Asn Gln Arg Leu Glu Lys Gln 
65                  70                  75                  80  


Met Gly Gln Arg Pro Arg Glu Ser Leu Lys Lys Ile Val Met Pro Ala 
                85                  90                  95      


Asn Ser Met Pro Ile Leu Asp Phe Phe Asp Asp Gly Lys Ser Pro Gln 
            100                 105                 110         


Asn Ser Pro Lys Ala Glu Pro Pro Lys Gln Asp Val Ala Pro Pro Ser 
        115                 120                 125             


Val Glu Lys Gln Leu Gln Glu Leu Met Lys Val Phe Thr Asp Phe Pro 
    130                 135                 140                 


Gln Met Asn Glu Ser Phe Leu Ala Asn Leu Gln Thr Met Lys Gln Lys 
145                 150                 155                 160 


Val Ser Glu Thr Asp Trp Lys Ser Phe Glu Ala Trp Met His Tyr Trp 
                165                 170                 175     


Leu Ile Phe Gln Met Ala Gln Lys Thr Ser Thr Pro Thr Pro Gln Pro 
            180                 185                 190         


Asp Gly Gly Ser Lys 
        195         


<210>  10
<211>  27
<212>  PRT
<213>  Boleophthalmus pectiniros

<400>  10

Asp Gln Lys Gln Gln Ile Gln Gly Leu Gln Thr Ser Asn Gln Arg Leu 
1               5                   10                  15      


Glu Lys Gln Met Gly Gln Arg Pro Arg Glu Ser 
            20                  25          


<210>  11
<211>  16
<212>  PRT
<213>  Boleophthalmus pectiniros

<400>  11

Gln Ile Gln Gly Leu Gln Thr Ser Asn Gln Arg Leu Glu Lys Gln Met 
1               5                   10                  15      


<210>  12
<211>  278
<212>  PRT
<213>  Boleophthalmus pectiniros

<400>  12

Met Glu His Ser Ser Glu Glu Ala Pro Leu Ala Ala Asp Ser Arg Ala 
1               5                   10                  15      


Gly Ser Glu Gln Val Leu Ile Pro Ala Ser Gly Thr Pro Gly Gly Ser 
            20                  25                  30          


Asn Gly His Ala Leu Lys Ile Ala Gly Ile Thr Thr Leu Val Cys Leu 
        35                  40                  45              


Leu Val Ser Ala Gln Val Phe Thr Ala Tyr Met Met Phe Asp Gln Lys 
    50                  55                  60                  


Gln Gln Ile Gln Asp Leu Gln Ala Thr Asn Gln Arg Met Glu Lys Gln 
65                  70                  75                  80  


Val Ser Leu Arg Ser Arg Val Ser Pro Gln Lys Met Val Met Pro Met 
                85                  90                  95      


Ala Ser Met Pro Leu Leu Asp Phe Ser Asp Asp Ser Asn Ala Pro Asn 
            100                 105                 110         


Pro Thr Thr Pro Lys Glu Ala Pro Lys Leu Asn Lys Thr Pro Ser Pro 
        115                 120                 125             


Pro Ser Val Glu Glu Gln Leu Met Asp Leu Met Lys Asp Leu Glu Leu 
    130                 135                 140                 


Pro His Phe Asn Lys Thr Phe Leu Ala Asn Leu Gln Thr Leu Lys Gln 
145                 150                 155                 160 


Gln Val Asn Glu Thr Ser Trp Lys Ser Leu Glu Ser Trp Leu Arg Tyr 
                165                 170                 175     


Trp Leu Ile Phe Gln Met Ala Gln Lys Ala Pro Thr Pro Gln Pro Ala 
            180                 185                 190         


Ser Glu Val Lys Thr Lys Cys Gln Ser Glu Ala Ala Ala Gly Val Ser 
        195                 200                 205             


Gly Leu Ile Gly Ala Tyr Arg Pro Gln Cys Asp Glu Gln Gly Asn Tyr 
    210                 215                 220                 


Lys Arg Met Gln Cys Trp His Ala Thr Arg Gln Cys Trp Cys Val Asp 
225                 230                 235                 240 


Glu Ser Gly Thr Pro Ile Asp Gly Ser Asn Thr Gln Gly Arg Pro Asn 
                245                 250                 255     


Cys Asp Gln Phe Leu Arg Ala Arg Arg Thr Lys Ser Asn Thr Leu Met 
            260                 265                 270         


Leu Ala Asp Leu Thr Asp 
        275             


<210>  13
<211>  27
<212>  PRT
<213>  Boleophthalmus pectiniros

<400>  13

Asp Gln Lys Gln Gln Ile Gln Asp Leu Gln Ala Thr Asn Gln Arg Met 
1               5                   10                  15      


Glu Lys Gln Val Ser Leu Arg Ser Arg Val Ser 
            20                  25          


<210>  14
<211>  16
<212>  PRT
<213>  Boleophthalmus pectiniros

<400>  14

Gln Ile Gln Asp Leu Gln Ala Thr Asn Gln Arg Met Glu Lys Gln Val 
1               5                   10                  15      


<210>  15
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is V, L or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is V or I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is V or A

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is L, I or F

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is V, T or L

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is A or V

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is V or L

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is V or I

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is M, S or A

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is S, A or G

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is A or V

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is M or F

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is I or T

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is I or A

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is F or M

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is L, M or V

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is V, F or L

<400>  15

Ala Xaa Lys Xaa Xaa Gly Xaa Thr Xaa Leu Xaa Cys Xaa Leu Xaa Xaa 
1               5                   10                  15      


Xaa Gln Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa 
            20                  25      


<210>  16
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  16

Leu Leu Pro Phe Tyr Pro Pro Asp Glu Ala Leu Glu Ile Gly Leu Glu 
1               5                   10                  15      


Leu Asn Ser Ser Ala Leu Pro Pro Thr 
            20                  25  


<210>  17
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  17

Ile Leu Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala Thr Tyr Leu Gln 
1               5                   10                  15      


Pro Ala Gln Ala Gln Met Leu Thr Pro 
            20                  25  


<210>  18
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  18

Lys Pro Leu Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile Met Ala Ile 
1               5                   10                  15      


Cys Gly Met Pro Leu Asp Ser Phe Arg 
            20                  25  


<210>  19
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  19

Val Ile Gln Thr Ser Lys Tyr Tyr Met Arg Asp Val Ile Ala Ile Glu 
1               5                   10                  15      


Ser Ala Trp Leu Leu Glu Leu Ala Pro 
            20                  25  


<210>  20
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  20

His Ile His Arg Ala Gly Gly Leu Phe Val Ala Asp Ala Ile Gln Val 
1               5                   10                  15      


Gly Phe Gly Arg Ile Gly Lys His Phe 
            20                  25  


<210>  21
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Penta antigen with N-terminal met and C-terminal HA tag

<400>  21

Met Leu Leu Pro Phe Tyr Pro Pro Asp Glu Ala Leu Glu Ile Gly Leu 
1               5                   10                  15      


Glu Leu Asn Ser Ser Ala Leu Pro Pro Thr Ile Leu Pro Gln Ala Pro 
            20                  25                  30          


Ser Gly Pro Ser Tyr Ala Thr Tyr Leu Gln Pro Ala Gln Ala Gln Met 
        35                  40                  45              


Leu Thr Pro Lys Pro Leu Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile 
    50                  55                  60                  


Met Ala Ile Cys Gly Met Pro Leu Asp Ser Phe Arg Val Ile Gln Thr 
65                  70                  75                  80  


Ser Lys Tyr Tyr Met Arg Asp Val Ile Ala Ile Glu Ser Ala Trp Leu 
                85                  90                  95      


Leu Glu Leu Ala Pro His Ile His Arg Ala Gly Gly Leu Phe Val Ala 
            100                 105                 110         


Asp Ala Ile Gln Val Gly Phe Gly Arg Ile Gly Lys His Phe Gly Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
    130                 135         


<210>  22
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of Boleophthalmus pectinirostris FL invariant 
       chain and multimeric antigen


<220>
<221>  MISC_FEATURE
<222>  (1)..(197)
<223>  Boleophthalmus pectinirostris FL invariant chain

<220>
<221>  MISC_FEATURE
<222>  (198)..(333)
<223>  Multimeric antigen

<400>  22

Met Glu His Ala Ser Glu Asp Ala Pro Leu Ala Arg Asp Ser Gly Thr 
1               5                   10                  15      


Gly Ser Glu Gln Ala Leu Val Val Pro Thr Ala Pro Arg Arg Gly Ser 
            20                  25                  30          


Asn Ser His Ala Val Lys Ile Ala Gly Ile Thr Thr Leu Val Cys Leu 
        35                  40                  45              


Leu Val Ser Ala Gln Val Phe Thr Ala Tyr Met Val Phe Asp Gln Lys 
    50                  55                  60                  


Gln Gln Ile Gln Gly Leu Gln Thr Ser Asn Gln Arg Leu Glu Lys Gln 
65                  70                  75                  80  


Met Gly Gln Arg Pro Arg Glu Ser Leu Lys Lys Ile Val Met Pro Ala 
                85                  90                  95      


Asn Ser Met Pro Ile Leu Asp Phe Phe Asp Asp Gly Lys Ser Pro Gln 
            100                 105                 110         


Asn Ser Pro Lys Ala Glu Pro Pro Lys Gln Asp Val Ala Pro Pro Ser 
        115                 120                 125             


Val Glu Lys Gln Leu Gln Glu Leu Met Lys Val Phe Thr Asp Phe Pro 
    130                 135                 140                 


Gln Met Asn Glu Ser Phe Leu Ala Asn Leu Gln Thr Met Lys Gln Lys 
145                 150                 155                 160 


Val Ser Glu Thr Asp Trp Lys Ser Phe Glu Ala Trp Met His Tyr Trp 
                165                 170                 175     


Leu Ile Phe Gln Met Ala Gln Lys Thr Ser Thr Pro Thr Pro Gln Pro 
            180                 185                 190         


Asp Gly Gly Ser Lys Leu Leu Pro Phe Tyr Pro Pro Asp Glu Ala Leu 
        195                 200                 205             


Glu Ile Gly Leu Glu Leu Asn Ser Ser Ala Leu Pro Pro Thr Ile Leu 
    210                 215                 220                 


Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala Thr Tyr Leu Gln Pro Ala 
225                 230                 235                 240 


Gln Ala Gln Met Leu Thr Pro Lys Pro Leu Arg Arg Asn Asn Ser Tyr 
                245                 250                 255     


Thr Ser Tyr Ile Met Ala Ile Cys Gly Met Pro Leu Asp Ser Phe Arg 
            260                 265                 270         


Val Ile Gln Thr Ser Lys Tyr Tyr Met Arg Asp Val Ile Ala Ile Glu 
        275                 280                 285             


Ser Ala Trp Leu Leu Glu Leu Ala Pro His Ile His Arg Ala Gly Gly 
    290                 295                 300                 


Leu Phe Val Ala Asp Ala Ile Gln Val Gly Phe Gly Arg Ile Gly Lys 
305                 310                 315                 320 


His Phe Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
                325                 330             


<210>  23
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of Paralichthys olivaceus FL invariant chain and 
       multimeric antigen


<220>
<221>  MISC_FEATURE
<222>  (1)..(187)
<223>  Paralichthys olivaceus FL invariant chain

<220>
<221>  MISC_FEATURE
<222>  (188)..(323)
<223>  Multimeric antigen

<400>  23

Met Ser Glu Thr Gln Thr Leu Leu Gly Ala Pro Arg Gln Gln Thr Ala 
1               5                   10                  15      


Val Asp Val Gly Ala Pro Ala Gln Gly Gly Arg Ser Ala Asn Ala Tyr 
            20                  25                  30          


Lys Val Val Gly Leu Thr Val Leu Ala Cys Val Leu Val Met Ser Gln 
        35                  40                  45              


Ala Met Ile Ile Tyr Phe Leu Val Asn Gln Arg Gly Asp Ile Lys Ser 
    50                  55                  60                  


Leu Glu Glu Gln His Ser Gly Leu Asn Glu Gln Leu Thr Lys Gly Arg 
65                  70                  75                  80  


Ser Ala Ser Met Ser Met Gln Leu Pro Ser Ser Phe His Ser Leu Thr 
                85                  90                  95      


Phe Asp Glu Lys Ser Ser Thr Arg Ala Pro Glu Glu Thr Gly Pro Pro 
            100                 105                 110         


Gln Ala Thr Gln Cys Gln Leu Glu Ala Ala Gly Glu Lys Pro Val Gln 
        115                 120                 125             


Val Pro Gly Leu Arg Pro Asp Cys Asp Glu Arg Gly Leu Tyr Arg Leu 
    130                 135                 140                 


Lys Gln Cys Leu Lys His Arg Cys Trp Cys Val Asn Pro Ala Asn Gly 
145                 150                 155                 160 


Glu Gln Ile Pro Gly Ser Leu Gly Lys Glu Asp Val Thr Cys Asn Lys 
                165                 170                 175     


Gly Val His Ser Val Gly Leu Asp Lys Val Leu Leu Leu Pro Phe Tyr 
            180                 185                 190         


Pro Pro Asp Glu Ala Leu Glu Ile Gly Leu Glu Leu Asn Ser Ser Ala 
        195                 200                 205             


Leu Pro Pro Thr Ile Leu Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala 
    210                 215                 220                 


Thr Tyr Leu Gln Pro Ala Gln Ala Gln Met Leu Thr Pro Lys Pro Leu 
225                 230                 235                 240 


Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile Met Ala Ile Cys Gly Met 
                245                 250                 255     


Pro Leu Asp Ser Phe Arg Val Ile Gln Thr Ser Lys Tyr Tyr Met Arg 
            260                 265                 270         


Asp Val Ile Ala Ile Glu Ser Ala Trp Leu Leu Glu Leu Ala Pro His 
        275                 280                 285             


Ile His Arg Ala Gly Gly Leu Phe Val Ala Asp Ala Ile Gln Val Gly 
    290                 295                 300                 


Phe Gly Arg Ile Gly Lys His Phe Gly Tyr Pro Tyr Asp Val Pro Asp 
305                 310                 315                 320 


Tyr Ala Ser 
            


<210>  24
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of Boleophthalmus pectinirostris invariant chain 
       FRAG_A fragment and multimeric antigen


<220>
<221>  MISC_FEATURE
<222>  (1)..(28)
<223>  Boleophthalmus pectinirostris invariant chain FRAG_A fragment

<220>
<221>  MISC_FEATURE
<222>  (29)..(164)
<223>  Multimeric antigen

<400>  24

Met Asp Gln Lys Gln Gln Ile Gln Gly Leu Gln Thr Ser Asn Gln Arg 
1               5                   10                  15      


Leu Glu Lys Gln Met Gly Gln Arg Pro Arg Glu Ser Leu Leu Pro Phe 
            20                  25                  30          


Tyr Pro Pro Asp Glu Ala Leu Glu Ile Gly Leu Glu Leu Asn Ser Ser 
        35                  40                  45              


Ala Leu Pro Pro Thr Ile Leu Pro Gln Ala Pro Ser Gly Pro Ser Tyr 
    50                  55                  60                  


Ala Thr Tyr Leu Gln Pro Ala Gln Ala Gln Met Leu Thr Pro Lys Pro 
65                  70                  75                  80  


Leu Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile Met Ala Ile Cys Gly 
                85                  90                  95      


Met Pro Leu Asp Ser Phe Arg Val Ile Gln Thr Ser Lys Tyr Tyr Met 
            100                 105                 110         


Arg Asp Val Ile Ala Ile Glu Ser Ala Trp Leu Leu Glu Leu Ala Pro 
        115                 120                 125             


His Ile His Arg Ala Gly Gly Leu Phe Val Ala Asp Ala Ile Gln Val 
    130                 135                 140                 


Gly Phe Gly Arg Ile Gly Lys His Phe Gly Tyr Pro Tyr Asp Val Pro 
145                 150                 155                 160 


Asp Tyr Ala Ser 
                


<210>  25
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of Paralichthys olivaceus invariant chain fragment
       FRAG_A and multimeric antigen


<220>
<221>  MISC_FEATURE
<222>  (1)..(28)
<223>  Paralichthys olivaceus invariant chain fragment FRAG_A

<220>
<221>  MISC_FEATURE
<222>  (29)..(164)
<223>  Multimeric antigen

<400>  25

Met Asn Gln Arg Gly Asp Ile Lys Ser Leu Glu Glu Gln His Ser Gly 
1               5                   10                  15      


Leu Asn Glu Gln Leu Thr Lys Gly Arg Ser Ala Ser Leu Leu Pro Phe 
            20                  25                  30          


Tyr Pro Pro Asp Glu Ala Leu Glu Ile Gly Leu Glu Leu Asn Ser Ser 
        35                  40                  45              


Ala Leu Pro Pro Thr Ile Leu Pro Gln Ala Pro Ser Gly Pro Ser Tyr 
    50                  55                  60                  


Ala Thr Tyr Leu Gln Pro Ala Gln Ala Gln Met Leu Thr Pro Lys Pro 
65                  70                  75                  80  


Leu Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile Met Ala Ile Cys Gly 
                85                  90                  95      


Met Pro Leu Asp Ser Phe Arg Val Ile Gln Thr Ser Lys Tyr Tyr Met 
            100                 105                 110         


Arg Asp Val Ile Ala Ile Glu Ser Ala Trp Leu Leu Glu Leu Ala Pro 
        115                 120                 125             


His Ile His Arg Ala Gly Gly Leu Phe Val Ala Asp Ala Ile Gln Val 
    130                 135                 140                 


Gly Phe Gly Arg Ile Gly Lys His Phe Gly Tyr Pro Tyr Asp Val Pro 
145                 150                 155                 160 


Asp Tyr Ala Ser 
                


<210>  26
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of Boleophthalmus pectinirostris invariant chain 
       fragment FRAG_B and multimeric antigen


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  Boleophthalmus pectinirostris invariant chain fragment FRAG_B

<220>
<221>  MISC_FEATURE
<222>  (18)..(153)
<223>  Multimeric antigen

<400>  26

Met Gln Ile Gln Gly Leu Gln Thr Ser Asn Gln Arg Leu Glu Lys Gln 
1               5                   10                  15      


Met Leu Leu Pro Phe Tyr Pro Pro Asp Glu Ala Leu Glu Ile Gly Leu 
            20                  25                  30          


Glu Leu Asn Ser Ser Ala Leu Pro Pro Thr Ile Leu Pro Gln Ala Pro 
        35                  40                  45              


Ser Gly Pro Ser Tyr Ala Thr Tyr Leu Gln Pro Ala Gln Ala Gln Met 
    50                  55                  60                  


Leu Thr Pro Lys Pro Leu Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile 
65                  70                  75                  80  


Met Ala Ile Cys Gly Met Pro Leu Asp Ser Phe Arg Val Ile Gln Thr 
                85                  90                  95      


Ser Lys Tyr Tyr Met Arg Asp Val Ile Ala Ile Glu Ser Ala Trp Leu 
            100                 105                 110         


Leu Glu Leu Ala Pro His Ile His Arg Ala Gly Gly Leu Phe Val Ala 
        115                 120                 125             


Asp Ala Ile Gln Val Gly Phe Gly Arg Ile Gly Lys His Phe Gly Tyr 
    130                 135                 140                 


Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
145                 150             


<210>  27
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of Paralichthys olivaceus invariant chain fragment
       FRAG_B and multimeric antigen


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  Paralichthys olivaceus invariant chain fragment FRAG_B

<220>
<221>  MISC_FEATURE
<222>  (18)..(153)
<223>  Multimeric antigen

<400>  27

Met Asp Ile Lys Ser Leu Glu Glu Gln His Ser Gly Leu Asn Glu Gln 
1               5                   10                  15      


Leu Leu Leu Pro Phe Tyr Pro Pro Asp Glu Ala Leu Glu Ile Gly Leu 
            20                  25                  30          


Glu Leu Asn Ser Ser Ala Leu Pro Pro Thr Ile Leu Pro Gln Ala Pro 
        35                  40                  45              


Ser Gly Pro Ser Tyr Ala Thr Tyr Leu Gln Pro Ala Gln Ala Gln Met 
    50                  55                  60                  


Leu Thr Pro Lys Pro Leu Arg Arg Asn Asn Ser Tyr Thr Ser Tyr Ile 
65                  70                  75                  80  


Met Ala Ile Cys Gly Met Pro Leu Asp Ser Phe Arg Val Ile Gln Thr 
                85                  90                  95      


Ser Lys Tyr Tyr Met Arg Asp Val Ile Ala Ile Glu Ser Ala Trp Leu 
            100                 105                 110         


Leu Glu Leu Ala Pro His Ile His Arg Ala Gly Gly Leu Phe Val Ala 
        115                 120                 125             


Asp Ala Ile Gln Val Gly Phe Gly Arg Ile Gly Lys His Phe Gly Tyr 
    130                 135                 140                 


Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
145                 150             


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is H or N

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is G or N

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is N or Q

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is E or A

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Q or E

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L or M

<400>  28

Asp Ile Lys Ser Leu Glu Glu Gln Xaa Ser Xaa Leu Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is G or D

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is T or A

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is T or S

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is L or M

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is M or V

<400>  29

Gln Ile Gln Xaa Leu Gln Xaa Xaa Asn Gln Arg Xaa Glu Lys Gln Xaa 
1               5                   10                  15      


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza tag

<400>  30

Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
1               5                   10      


