                         SEQUENCE LISTING

<110>  Janssen Vaccine & Prevention B.V.
 
<120>  ANTI-SYNUCLEIN ANTIBODIES

<130>  6888097.514US

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  323.1 heavy chain variable region

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Ser 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Asn Lys Ala Asn Asn Tyr Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg His Leu Ser Leu Gly Gly Asn Ser Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  323.1 light chain variable region

<400>  2

Asp Val Val Met Thr Gln Ser Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln Ser Pro Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Thr Ile Ser Asn Arg Phe Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  336.1 heavy chain variable region

<400>  3

Glu Val Gln Leu Val Gln Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Phe Ile Thr Gly Asp Gly Ser Arg Ile Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Phe Asn His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  336.1 light chain variable region

<400>  4

Ala Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Ala Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr Thr Thr His Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  338.1 heavy chain variable region

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Ile Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Phe Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Thr Phe Gly Asn Lys Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Ser Ile Ser Arg Asp Asn Thr Lys Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Leu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  338.1 light chain variable region

<400>  6

Ala Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Ala Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr Thr Thr His Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  323.1 heavy chain CDR1

<400>  7

Ala Ser Ala Met His 
1               5   


<210>  8
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  323.1 heavy chain CDR2

<400>  8

Arg Ile Arg Asn Lys Ala Asn Asn Tyr Ala Thr Ala Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  323.1 heavy cain CDR3

<400>  9

His Leu Ser Leu Gly Gly Asn Ser Val Asp Tyr 
1               5                   10      


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  336.1 heavy chain CDR1

<400>  10

Thr Tyr Ala Ile Ser 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  336.1 heavy chain CDR2

<400>  11

Phe Ile Thr Gly Asp Gly Ser Arg Ile Leu Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  336.1 heavy chain CDR3

<400>  12

Asn His Tyr 
1           


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  338.1 heavy chain CDR1

<400>  13

Ser Tyr Trp Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  338.1 heavy chain CDR2

<400>  14

Arg Ile Asn Thr Phe Gly Asn Lys Thr Ser Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  338.1 heavy chain CDR3

<400>  15

Ser Thr Leu Gly Ser Phe Asp Tyr 
1               5               


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  323.1 light chain CDR1

<400>  16

Arg Ala Ser Gln Ser Pro Val His Ser Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  323.1 light chain CDR2

<400>  17

Thr Ile Ser Asn Arg Phe Pro 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  323.1 light chain CDR3

<400>  18

Met Gln Gly Thr Gln Phe Pro Tyr Thr 
1               5                   


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  336.1 light chain CDR1

<400>  19

Lys Ala Ser Gln Ser Leu Leu Tyr Ser Ser Asn Asn Arg Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  336.1 light chain CDR2

<400>  20

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  336.1 light chain CDR3

<400>  21

His Gln Tyr Tyr Thr Thr His Ser 
1               5               


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  338.1 light chain CDR1

<400>  22

Thr Ser Ser Gln Ser Leu Phe Asp Ile Ser Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  338.1 light chain CDR2

<400>  23

Thr Leu Ser Tyr Arg Ala Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  338.1 light chain CDR3

<400>  24

Met Gln Arg Ile Glu Ser Pro Ser Thr 
1               5                   


<210>  25
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synuclein 1-25

<400>  25

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly 
            20                  25  


<210>  26
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synuclein 18-44

<400>  26

Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys Thr 
1               5                   10                  15      


Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr 
            20                  25          


<210>  27
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synuclein 40-65

<400>  27

Val Gly Ser Lys Thr Lys Glu Gly Val Val His Gly Val Ala Thr Val 
1               5                   10                  15      


Ala Glu Lys Thr Lys Glu Gln Val Thr Asn 
            20                  25      


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synuclein 121-140

<400>  28

Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr 
1               5                   10                  15      


Glu Pro Glu Ala 
            20  


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synuclein 111-140

<400>  29

Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu 
1               5                   10                  15      


Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
            20                  25                  30  


<210>  30
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synuclein 111-140 (pS129)


<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  PHOSPHORYLATION

<400>  30

Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu 
1               5                   10                  15      


Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
            20                  25                  30  


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synuclein 111-121

<400>  31

Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp 
1               5                   10      


