                         SEQUENCE LISTING

<110>  INHIBRX, INC.
 
<120>  PD-1 SINGLE DOMAIN ANTIBODIES AND THERAPEUTIC COMPOSITIONS 
       THEREOF

<130>  INHI-041/001WO 322124-2198

<140>  PCT/US2019/055929
<141>  2019-10-11

<150>  US 62/791,152
<151>  2019-01-11

<150>  US 62/774,615
<151>  2018-10-11

<160>  323   

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker

<400>  1

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker

<400>  2

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker

<400>  3

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker

<400>  4

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Glycine linker

<400>  5

Gly Gly Gly Gly 
1               


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Glycine linker

<400>  6

Gly Gly Gly Gly Gly 
1               5   


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Glycine linker

<400>  7

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  8
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  8

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        35                  40                  45              


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            180                 185                 190         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215             


<210>  9
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc xELL Fc region

<400>  9

Pro Ala Pro Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
1               5                   10                  15      


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            20                  25                  30          


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        35                  40                  45              


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    50                  55                  60                  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
65                  70                  75                  80  


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                85                  90                  95      


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            100                 105                 110         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        115                 120                 125             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    130                 135                 140                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
145                 150                 155                 160 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                165                 170                 175     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            180                 185                 190         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        195                 200                 205             


Leu Ser Leu Ser Pro Gly Lys 
    210                 215 


<210>  10
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  10

Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  11
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp 
        35                  40                  45              


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  


Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            100                 105                 110         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn 
145                 150                 155                 160 


Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            180                 185                 190         


Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr 
        195                 200                 205             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215             


<210>  12
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
        35                  40                  45              


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
        115                 120                 125             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
            180                 185                 190         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215             


<210>  13
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  13

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
        35                  40                  45              


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
        115                 120                 125             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
            180                 185                 190         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215             


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  modified IgG1 hinge

<400>  14

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  truncated IgG1 hinge

<400>  15

Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  modified IgG4 hinge

<400>  16

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
1               5                   10      


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  carboxy-terminal sequence

<400>  17

Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  carboxy-terminal sequence

<400>  18

Gly Gln Gly Thr Leu Val Thr Val Glu Pro Gly Gly 
1               5                   10          


<210>  19
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OKT3 VH

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  20
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OKT3 VL

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
            100                 105     


<210>  21
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OKT3 humanized VH

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OKT3 humanized VH

<400>  22

Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  23
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OKT3 humanized VH

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  24
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OKT3 humanized VL

<400>  24

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            100                 105     


<210>  25
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OKT3 humanized VL

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  26
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OKT3 humanized VL

<400>  26

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ile Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Met Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             


<210>  27
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 Hv

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 


<210>  28
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 Lv

<400>  28

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH CDR1

<400>  29

Thr Tyr Ala Met Asn 
1               5   


<210>  30
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH CDR2

<400>  30

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH CDR3

<400>  31

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL CDR1

<400>  32

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL CDR2

<400>  33

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL CDR3

<400>  34

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  35
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH1

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  36
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH2

<400>  36

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  37
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH3

<400>  37

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  38
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH4

<400>  38

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  39
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH5

<400>  39

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  40
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH6

<400>  40

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  41
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH7

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asp Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  42
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH8

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 


<210>  43
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH9

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  44
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH10

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  45
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH11

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  46
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH12

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
        115                 120                 125 


<210>  47
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH13

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
        115                 120                 125 


<210>  48
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH14

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Cys Gly Thr Leu Val Thr Val Lys Pro 
        115                 120                 125 


<210>  49
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH15

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  50
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH16

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  51
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH17

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  52
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH18

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  53
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH19

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  54
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH20

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  55
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH21

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  56
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH22

<400>  56

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  57
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH23

<400>  57

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  58
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH24

<400>  58

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  59
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH25

<400>  59

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  60
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH26

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  61
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH27

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asp Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  62
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH28

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 


<210>  63
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH29

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  64
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH30

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  65
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VH31

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  66
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL1

<400>  66

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  67
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL2

<400>  67

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Lys Ser Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  68
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL3

<400>  68

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  69
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL4

<400>  69

Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  70
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL5

<400>  70

Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  71
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL6

<400>  71

Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  72
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL7

<400>  72

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  73
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL8

<400>  73

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  74
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL9

<400>  74

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  75
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL10

<400>  75

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  76
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL11

<400>  76

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Glu Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  77
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL12

<400>  77

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  78
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL13

<400>  78

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Lys Ser Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  79
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL14

<400>  79

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  80
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL15

<400>  80

Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  81
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL16

<400>  81

Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  82
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL17

<400>  82

Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  83
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL18

<400>  83

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  84
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL19

<400>  84

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  85
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VHH

<400>  85

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Asn Thr Met Ser 
65                  70                  75                  80  


Leu Gln Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Pro Thr Glu Lys Gly Ser Ser Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Arg Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr 
    


<210>  86
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FR alpha sdAb

<400>  86

Gln Leu Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asn Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Gly Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Leu Val Pro Ala Cys Thr Tyr Ser Asn Gly Arg Gly Pro 
            100                 105                 110         


Leu Asp Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Lys 
        115                 120                 125             


Pro 
    


<210>  87
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FR alpha sdAb

<400>  87

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asp 
            20                  25                  30          


Ala Thr Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ile Ile Thr Ser Ser Gly Ser Thr Asn Tyr Pro Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Ile Thr Arg Tyr Gly Gly Ser Thr Tyr Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Lys Pro 
        115                 


<210>  88
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FR alpha sdAb

<400>  88

Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu 
1               5                   10                  15      


Thr Phe Gly Val Val Phe Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Arg Glu Phe Val Ala Arg Val Thr Gly Thr Asp Thr Val Asp 
        35                  40                  45              


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Phe Ala 
    50                  55                  60                  


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Asn Thr Gly Ala Tyr Trp Gly Gln Gly Thr Leu 
                85                  90                  95      


Val Thr Val Lys Pro 
            100     


<210>  89
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cMET sdAb

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Asp Ala Ser Asp Asp Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Ile Gly Leu Ser Ser Ser Cys Leu Leu Glu Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
        115                 120                 125 


<210>  90
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD20 scFv

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Thr Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser 
            180                 185                 190         


Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  91
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD20 VH

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  92
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD20 VL

<400>  92

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val 
        115 


<210>  93
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DLL3 scFv

<400>  93

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ile Ala Val Thr Gly Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Arg Val Asn Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
                165                 170                 175     


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Arg Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  94
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DLL3 scFv

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ile Ala Val Thr Gly Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Arg Val Asn Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
                165                 170                 175     


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Arg Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  95
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DLL3 Fd

<400>  95

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Ala Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Ser 
65                  70                  75                  80  


Leu Gln Ile Ile Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ile Gly Asp Ser Ser Pro Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  96
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DLL3 LC

<400>  96

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ala Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Ser Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  97
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  5T4 Fd

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gln Trp Asp Tyr Asp Val Arg Ala Met Asn Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys 
225 


<210>  98
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  5T4 LC

<400>  98

Asp Ile Val Met Thr Gln Ser His Ile Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg Leu Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  99
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-5T4 VH


<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa can be any amino acid

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Xaa Cys Val Arg Gln Trp Asp Tyr Asp Val Arg Ala Met Asn Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  100
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-5T4 VL

<400>  100

Asp Ile Val Met Thr Gln Ser His Ile Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg Leu Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  101
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  gpNMB Fd

<400>  101

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Phe 
            20                  25                  30          


Asn Tyr Tyr Trp Ser Trp Ile Arg His His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Ser Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Thr Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Tyr Asn Trp Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  102
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  gpNMB LC

<400>  102

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Asn Asn 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  103
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Knob Fc

<400>  103

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Thr 
225     


<210>  104
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  104

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Arg Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Thr 
225     


<210>  105
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Knob Fc

<400>  105

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Thr 
    210                 215                 220             


<210>  106
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  106

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Arg Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    130                 135                 140                 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Thr 
    210                 215                 220             


<210>  107
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Knob Fc

<400>  107

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  108
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  108

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Arg Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  109
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Knob Fc

<400>  109

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220             


<210>  110
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  110

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Arg Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    130                 135                 140                 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220             


<210>  111
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  111

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Thr 
225     


<210>  112
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  112

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    130                 135                 140                 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Thr 
    210                 215                 220             


<210>  113
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  113

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  114
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  114

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    130                 135                 140                 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220             


<210>  115
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Knob Fc

<400>  115

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Val 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Thr 
225     


<210>  116
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Knob Fc

<400>  116

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Val His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Thr 
    210                 215                 220             


<210>  117
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Knob Fc

<400>  117

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Val 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  118
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Knob Fc

<400>  118

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Val His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220             


<210>  119
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  119

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Val 
        195                 200                 205             


His Glu Ala Leu His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Thr 
225     


<210>  120
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  120

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    130                 135                 140                 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Val His Glu Ala 
        195                 200                 205             


Leu His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Thr 
    210                 215                 220             


<210>  121
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  121

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Val 
        195                 200                 205             


His Glu Ala Leu His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  122
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hole Fc

<400>  122

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    130                 135                 140                 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Val His Glu Ala 
        195                 200                 205             


Leu His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220             


<210>  123
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker


<220>
<221>  MISC_FEATURE
<222>  (4)..(6)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(9)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (10)..(12)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (13)..(15)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(18)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (19)..(21)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (22)..(24)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (25)..(27)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (28)..(30)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(33)
<223>  May be present or absent

<400>  123

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser 
    


<210>  124
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker


<220>
<221>  MISC_FEATURE
<222>  (7)..(12)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (13)..(18)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (19)..(24)
<223>  May be present or absent

<400>  124

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Gly Ser 
            20                  


<210>  125
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker

<400>  125

Gly Gly Gly Gly Ser 
1               5   


<210>  126
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker

<400>  126

Gly Gly Gly Gly Gly Ser 
1               5       


<210>  127
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker

<400>  127

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  128
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker

<400>  128

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  129
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker

<400>  129

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  up to 4 of the amino acids may be absent

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is independently selected from Ala, Val, Leu, Ile, Met,
       Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, Asn, Gln, Lys, Arg, 
       His, Asp and Glu

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  up to 4 of the amino acids may be absent

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is independently selected from Ala, Val, Leu, Ile, Met,
       Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, Asn, Gln, Lys, Arg, 
       His, Asp and Glu

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  up to 4 of the amino acids may be absent

<400>  130

Gly Gly Gly Gly Gly Xaa Gly Gly Gly Gly Gly Xaa Gly Gly Gly Gly 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is independently selected from Ala, Val, Leu, Ile, Met,
       Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, Asn, Gln, Lys, Arg, 
       His, Asp and Glu

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is independently selected from Ala, Val, Leu, Ile, Met,
       Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, Asn, Gln, Lys, Arg, 
       His, Asp and Glu

<400>  131

Gly Gly Gly Xaa Gly Gly Gly Xaa Gly Gly Gly 
1               5                   10      


<210>  132
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<220>
<221>  MISC_FEATURE
<222>  (6)..(10)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (26)..(30)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(35)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (36)..(40)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (41)..(45)
<223>  May be present or absent

<400>  132

Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser 
1               5                   10                  15      


Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
        35                  40                  45  


<210>  133
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<400>  133

Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly 
1               5                   10      


<210>  134
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (26)..(30)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(35)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (36)..(40)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (41)..(45)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (46)..(50)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (51)..(55)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(60)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (61)..(65)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (66)..(70)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (71)..(75)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (76)..(80)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (81)..(85)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (86)..(90)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (91)..(95)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (96)..(100)
<223>  May be present or absent

<400>  134

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
        35                  40                  45              


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
    50                  55                  60                  


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
                85                  90                  95      


Ala Ala Ala Lys 
            100 


<210>  135
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(10)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (19)..(20)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (23)..(24)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (25)..(26)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (27)..(28)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (29)..(30)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (33)..(34)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (35)..(36)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (37)..(38)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (39)..(40)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (41)..(42)
<223>  May be present or absent

<400>  135

Ala Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Thr 
        35                  40                  


<210>  136
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (18)..(22)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (23)..(27)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (28)..(32)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (33)..(37)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (38)..(42)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (43)..(47)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (48)..(52)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (53)..(57)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (58)..(62)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (63)..(67)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (68)..(72)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (73)..(77)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (78)..(82)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (83)..(87)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (88)..(92)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (93)..(97)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (98)..(102)
<223>  May be present or absent

<400>  136

Ala Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25                  30          


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
        35                  40                  45              


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
    50                  55                  60                  


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
65                  70                  75                  80  


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                85                  90                  95      


Lys Glu Ala Ala Ala Lys Gly Thr 
            100                 


<210>  137
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (26)..(30)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(35)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (36)..(40)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (41)..(45)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (46)..(50)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (51)..(55)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(60)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (61)..(65)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (66)..(70)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (71)..(75)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (76)..(80)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (81)..(85)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (86)..(90)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (91)..(95)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (96)..(100)
<223>  May be present or absent

<400>  137

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly 
            20                  25                  30          


Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly 
        35                  40                  45              


Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly 
    50                  55                  60                  


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala 
65                  70                  75                  80  


Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
                85                  90                  95      


Gly Gly Gly Ala 
            100 


<210>  138
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (26)..(30)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(35)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (36)..(40)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (41)..(45)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (46)..(50)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (51)..(55)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(60)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (61)..(65)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (66)..(70)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (71)..(75)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (76)..(80)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (81)..(85)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (86)..(90)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (91)..(95)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (96)..(100)
<223>  May be present or absent

<400>  138

Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro 
1               5                   10                  15      


Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly 
            20                  25                  30          


Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly 
        35                  40                  45              


Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly 
    50                  55                  60                  


Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser 
65                  70                  75                  80  


Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro 
                85                  90                  95      


Gly Gly Gly Ser 
            100 


<210>  139
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (26)..(30)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(35)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (36)..(40)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (41)..(45)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (46)..(50)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (51)..(55)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(60)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (61)..(65)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (66)..(70)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (71)..(75)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (76)..(80)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (81)..(85)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (86)..(90)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (91)..(95)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (96)..(100)
<223>  May be present or absent

<400>  139

Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala 
1               5                   10                  15      


Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly 
            20                  25                  30          


Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly 
        35                  40                  45              


Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly 
    50                  55                  60                  


Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser 
65                  70                  75                  80  


Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala 
                85                  90                  95      


Gly Gly Gly Ser 
            100 


<210>  140
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<220>
<221>  MISC_FEATURE
<222>  (32)..(45)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (46)..(59)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (60)..(73)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (74)..(87)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (88)..(101)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (102)..(115)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (116)..(129)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (130)..(143)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (144)..(157)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (158)..(171)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (172)..(185)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (186)..(199)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (200)..(213)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (214)..(227)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (228)..(241)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (242)..(255)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (256)..(269)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (270)..(283)
<223>  May be present or absent

<400>  140

Gly Gly Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10                  15      


Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu 
            20                  25                  30          


Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys 
        35                  40                  45              


Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser 
    50                  55                  60                  


Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser 
                85                  90                  95      


Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser 
            100                 105                 110         


Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
        115                 120                 125             


Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu 
    130                 135                 140                 


Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys 
145                 150                 155                 160 


Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser 
                165                 170                 175     


Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
            180                 185                 190         


Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser 
        195                 200                 205             


Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser 
    210                 215                 220                 


Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
225                 230                 235                 240 


Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu 
                245                 250                 255     


Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys 
            260                 265                 270         


Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Ser 
        275                 280                 285     


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<400>  141

Ser Ser Ser Ala Ser Ala Ser Ser Ala 
1               5                   


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<400>  142

Gly Ser Pro Gly Ser Pro Gly 
1               5           


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<400>  143

Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr 
1               5                   10      


<210>  144
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Ile, Leu, Tyr, Met, Phe, Val or Ala

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Ala, Gly, Ser, Val, Glu, Asp, Gln, Asn or Tyr

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is His, Pro, Ala, Val, Gly, Ser or Thr

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Asp or Glu

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Ile, Leu, Tyr, Met, Phe, Val, Thr, Ser, Gly 
       or Ala

<400>  144

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  145
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Ile or Leu

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Pro or Ala

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Ile, Val, Thr, Ser, or Gly

<400>  145

Xaa Glu Xaa Asp Xaa 
1               5   


<210>  146
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  substrate for granzyme B

<400>  146

Leu Glu Ala Asp 
1               


<210>  147
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  substrate for granzyme B

<400>  147

Leu Glu Pro Asp 
1               


<210>  148
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  substrate for granzyme B

<400>  148

Leu Glu Ala Glu 
1               


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  149

Ile Glu Pro Asp Ile 
1               5   


<210>  150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  150

Leu Glu Pro Asp Gly 
1               5   


<210>  151
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  151

Leu Glu Ala Asp Thr 
1               5   


<210>  152
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  152

Ile Glu Pro Asp Gly 
1               5   


<210>  153
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  153

Ile Glu Pro Asp Val 
1               5   


<210>  154
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  154

Ile Glu Pro Asp Ser 
1               5   


<210>  155
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  155

Ile Glu Pro Asp Thr 
1               5   


<210>  156
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Ala or Val

<400>  156

Xaa Gln Ala Arg Xaa 
1               5   


<210>  157
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Ala or Val

<400>  157

Arg Gln Ala Arg Xaa 
1               5   


<210>  158
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  substrate for matriptase

<400>  158

Arg Gln Ala Arg 
1               


<210>  159
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  159

Arg Gln Ala Arg Val 
1               5   


<210>  160
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Pro, Val or Ala

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Gln or Asp

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Ala or Asn

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Leu, Ile or Met

<400>  160

Xaa Xaa Xaa Xaa 
1               


<210>  161
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Gln or Asp

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Ala or Asn

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Leu or Ile

<400>  161

Pro Xaa Xaa Xaa 
1               


<210>  162
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  substrate for MMP

<400>  162

Pro Ala Gly Leu 
1               


<210>  163
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  163

Thr Gly Leu Glu Ala Asp Gly Ser Pro Ala Gly Leu Gly Arg Gln Ala 
1               5                   10                  15      


Arg Val Gly 
            


<210>  164
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  164

Thr Gly Leu Glu Ala Asp Gly Ser Arg Gln Ala Arg Val Gly Pro Ala 
1               5                   10                  15      


Gly Leu Gly 
            


<210>  165
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  165

Thr Gly Ser Pro Ala Gly Leu Glu Ala Asp Gly Ser Arg Gln Ala Arg 
1               5                   10                  15      


Val Gly Ser 
            


<210>  166
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  166

Thr Gly Pro Ala Gly Leu Gly Leu Glu Ala Asp Gly Ser Arg Gln Ala 
1               5                   10                  15      


Arg Val Gly 
            


<210>  167
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  167

Thr Gly Arg Gln Ala Arg Val Gly Leu Glu Ala Asp Gly Ser Pro Ala 
1               5                   10                  15      


Gly Leu Gly 
            


<210>  168
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  168

Thr Gly Ser Arg Gln Ala Arg Val Gly Pro Ala Gly Leu Glu Ala Asp 
1               5                   10                  15      


Gly Ser 
        


<210>  169
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  169

Thr Gly Pro Ala Gly Leu Gly Ser Arg Gln Ala Arg Val Gly Leu Glu 
1               5                   10                  15      


Ala Asp Gly Ser 
            20  


<210>  170
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  170

Gly Pro Ala Gly Leu Gly Leu Glu Pro Asp Gly Ser Arg Gln Ala Arg 
1               5                   10                  15      


Val Gly 
        


<210>  171
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  171

Gly Gly Ser Gly Gly Gly Gly Ile Glu Pro Asp Ile Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  172
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  172

Gly Gly Ser Gly Gly Gly Gly Leu Glu Ala Asp Thr Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  173
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  173

Gly Ser Ile Glu Pro Asp Ile Gly Ser 
1               5                   


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  174

Gly Ser Leu Glu Ala Asp Thr Gly Ser 
1               5                   


<210>  175
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  175

Gly Gly Ser Gly Gly Gly Gly Ile Glu Pro Asp Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  176
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  176

Gly Gly Ser Gly Gly Gly Gly Ile Glu Pro Asp Val Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  177
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  177

Gly Gly Ser Gly Gly Gly Gly Ile Glu Pro Asp Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  178
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  178

Gly Gly Ser Gly Gly Gly Gly Ile Glu Pro Asp Thr Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  179
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  179

Gly Gly Gly Ser Leu Glu Pro Asp Gly Ser Gly Ser 
1               5                   10          


<210>  180
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  180

Gly Pro Ala Gly Leu Gly Leu Glu Ala Asp Gly Ser Arg Gln Ala Arg 
1               5                   10                  15      


Val Gly 
        


<210>  181
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  181

Gly Gly Glu Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15  


<210>  182
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  182

Gly Ser Ser Ala Gly Ser Glu Ala Gly Gly Ser Gly Gln Ala Gly Val 
1               5                   10                  15      


Gly Ser 
        


<210>  183
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  183

Gly Gly Ser Gly Gly Gly Gly Leu Glu Ala Glu Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  184
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  184

Gly Gly Ser Gly Gly Gly Gly Ile Glu Pro Asp Pro Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  185
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  185

Thr Gly Gly Ser Gly Gly Gly Gly Ile Glu Pro Asp Ile Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser 
            


<210>  186
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BBL

<400>  186

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Asn 
    130                 135                 140                 


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
145                 150                 155                 160 


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
                165                 170                 175     


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
            180                 185                 190         


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 


<210>  187
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB VH

<400>  187

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  188
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB VL

<400>  188

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Lys Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Tyr Thr Gly Phe Gly Ser Leu 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  189
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB VH

<400>  189

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  190
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB VL

<400>  190

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  191
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB VH

<400>  191

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Met Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Met Ala Met Arg Leu Glu Leu Asp Lys Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  192
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB VL

<400>  192

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105     


<210>  193
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB Anticalin

<400>  193

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Gln Ala Gly Asn Ile Lys Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Asn Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Gly Val Thr Phe Asp Asp Lys Lys Cys Thr Tyr Ala Ile 
65                  70                  75                  80  


Ser Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser Phe Pro Gly His Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Glu Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  194
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB Anticalin

<400>  194

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Gln Ala Gly Asn Ile Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ile Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Met Val Lys Phe Asp Asp Lys Lys Cys Met Tyr Asp Ile 
65                  70                  75                  80  


Trp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser Phe Pro Gly His Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Glu Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  195
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB Anticalin

<400>  195

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Gln Ala Gly Asn Ile Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Asn Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ala Val Ala Phe Asp Asp Lys Lys Cys Thr Tyr Asp Ile 
65                  70                  75                  80  


Trp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser Phe Pro Gly His Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Glu Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  196
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB Anticalin

<400>  196

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Gln Ala Gly Asn Ile Lys Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Asn Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ala Val Ala Phe Asp Asp Lys Lys Cys Thr Tyr Asp Ile 
65                  70                  75                  80  


Trp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser Phe Pro Gly His Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Glu Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  197
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB Anticalin

<400>  197

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Gln Ala Gly Asn Ile Lys Leu Arg Glu Asp Ser Lys Met 
        35                  40                  45              


Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr 
    50                  55                  60                  


Gly Val Ser Phe Asp Asp Lys Lys Cys Thr Tyr Ala Ile Met Thr Phe 
65                  70                  75                  80  


Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys Ile Lys Ser 
                85                  90                  95      


Phe Pro Gly His Thr Ser Ser Leu Val Arg Val Val Ser Thr Asn Tyr 
            100                 105                 110         


Asn Gln His Ala Met Val Phe Phe Lys Phe Val Phe Gln Asn Arg Glu 
        115                 120                 125             


Glu Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu 
    130                 135                 140                 


Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu 
145                 150                 155                 160 


Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
                165                 170                 175 


<210>  198
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB Anticalin

<400>  198

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Gln Ala Gly Asn Ile Lys Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Val Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Gly Val Thr Phe Asp Asp Lys Lys Cys Arg Tyr Asp Ile 
65                  70                  75                  80  


Ser Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Phe Gly Lys 
                85                  90                  95      


Ile Lys Ser Phe Pro Gly His Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Glu Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  199
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB Anticalin

<400>  199

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Gln Ala Gly Asn Ile Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


His Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Gly Val Thr Phe Asp Asp Lys Lys Cys Thr Tyr Ala Ile 
65                  70                  75                  80  


Ser Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser Phe Pro Gly His Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Glu Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  200
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB Anticalin

<400>  200

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Gln Ala Gly Asn Ile Lys Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Asn Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Gly Val Thr Phe Asp Asp Lys Lys Cys Thr Tyr Ala Ile 
65                  70                  75                  80  


Ser Thr Leu Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Phe Gly Lys 
                85                  90                  95      


Ile Lys Ser Phe Pro Gly His Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Glu Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  201
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB Anticalin

<400>  201

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Gln Ala Gly Asn Ile Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ser Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ala Val Thr Phe Asp Asp Lys Lys Cys Asn Tyr Ala Ile 
65                  70                  75                  80  


Ser Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser Phe Pro Gly His Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Glu Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  202
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  202

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 


<210>  203
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  203

Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
1               5                   10                  15      


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            20                  25                  30          


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        35                  40                  45              


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    50                  55                  60                  


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
65                  70                  75                  80  


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                85                  90                  95      


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            100                 105                 110         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        115                 120                 125             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    130                 135                 140                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
145                 150                 155                 160 


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170 


<210>  204
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  204

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 175 


<210>  205
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  205

Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
1               5                   10                  15      


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
            20                  25                  30          


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
        35                  40                  45              


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
    50                  55                  60                  


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
65                  70                  75                  80  


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                85                  90                  95      


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
            100                 105                 110         


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
        115                 120                 125             


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
    130                 135                 140                 


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
145                 150                 155                 160 


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
                165                 170                 175     


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
            180                 185                 190         


Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200             


<210>  206
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  206

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu 
        


<210>  207
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  207

Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
1               5                   10                  15      


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            20                  25                  30          


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        35                  40                  45              


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    50                  55                  60                  


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
65                  70                  75                  80  


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                85                  90                  95      


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            100                 105                 110         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        115                 120                 125             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    130                 135                 140                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
145                 150                 155                 160 


Pro Ala Gly Leu 
                


<210>  208
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  208

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu 
                165                 


<210>  209
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  209

Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
1               5                   10                  15      


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
            20                  25                  30          


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
        35                  40                  45              


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
    50                  55                  60                  


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
65                  70                  75                  80  


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                85                  90                  95      


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
            100                 105                 110         


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
        115                 120                 125             


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
    130                 135                 140                 


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
145                 150                 155                 160 


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
                165                 170                 175     


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
            180                 185                 190         


Ile Pro Ala Gly Leu 
        195         


<210>  210
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  41BB sdAb

<400>  210

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Glu Ser Gly Arg Asn Thr Val Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Leu Leu Lys Gly Asn Arg Val Val Ser Pro Ser Val Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Lys Pro 
        115                 120     


<210>  211
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40 ligand

<400>  211

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  212
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40 ligand

<400>  212

Gln Val Ser His Arg Tyr Pro Arg Phe Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  213
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40 ligand

<400>  213

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  214
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40 ligand

<400>  214

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  215
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40 ligand

<400>  215

Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr 
1               5                   10                  15      


Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
            20                  25                  30          


Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly 
        35                  40                  45              


Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile 
    50                  55                  60                  


Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
65                  70                  75                  80  


Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                85                  90                  95      


Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe 
            100                 105                 110         


His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu 
        115                 120                 125             


Phe Cys Val Leu 
    130         


<210>  216
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40 VH

<400>  216

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Ser 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Met Tyr Pro Asp Asn Gly Asp Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Leu Ala Pro Arg Trp Tyr Phe Ser Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  217
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40 VL

<400>  217

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  218
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40 VH

<400>  218

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ala Asn Ser Tyr Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Gly Ile Tyr Asp Ser Ser Gly Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  219
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40 VL

<400>  219

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  220
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40 sdAb

<400>  220

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Phe Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Asn Arg Gly Leu Lys Thr Ala Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Val Asp Gly Asp Phe Arg Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  221
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITR ligand

<400>  221

Gln Leu Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu 
1               5                   10                  15      


Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys 
            20                  25                  30          


Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile 
        35                  40                  45              


Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe 
    50                  55                  60                  


Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn 
65                  70                  75                  80  


Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly 
                85                  90                  95      


Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn 
            100                 105                 110         


Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
        115                 120                 125             


<210>  222
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITR VH

<400>  222

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Gly Gly Tyr Tyr Asp Ser Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  223
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITR VL

<400>  223

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Val Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  224
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITR VH

<400>  224

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Gln Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Arg Arg Tyr Phe Pro Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  225
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITR VL

<400>  225

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Thr Asp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  226
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITR VH

<400>  226

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Phe Tyr Tyr Asp Thr Ser Gly Pro Arg Gly Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  227
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITR VL

<400>  227

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ser Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  228
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITR VH

<400>  228

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Pro Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Leu Gly Arg Tyr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  229
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITR VL

<400>  229

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  230
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITR sdAb

<400>  230

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Phe Ser Ile Asp 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Leu Ser Gly Ile Ser Ser Ala Lys Tyr Ala Ala Ser Ala Pro 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asp Val Ser Thr Gly Trp Gly Arg Asp Ala His Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val 
        115                 


<210>  231
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  232
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD70 VH

<400>  232

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Asn Trp Gly Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  233
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD70 VL

<400>  233

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  234
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ICOS sdAb

<400>  234

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Gly Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Leu Thr Ser Gly Gly Ser Val Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Arg Ala Glu Ile Phe Thr Arg Thr Gly Glu Asn Tyr Tyr Gly Met Asp 
            100                 105                 110         


Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Lys Pro 
        115                 120                 


<210>  235
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD28 sdAb

<400>  235

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Met Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Tyr Arg Arg Asp Ala Ala Asp Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Phe Thr Tyr Ala Gly Trp Ala Ser Ser Arg Arg Asp Asp Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
        115                 120                 


<210>  236
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD3zeta signaling domain

<400>  236

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  237
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  4-1BB-derived costimulatory domain

<400>  237

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  238
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD28-derived costimulatory domain

<400>  238

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  239
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD28-derived costimulatory domain 2

<400>  239

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  240
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD28-derived costimulatory domain 3

<400>  240

Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
1               5                   10                  15      


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            20                  25                  30          


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40                  


<210>  241
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8-derived hinge and transmembrane domain

<400>  241

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile 
        35                  40                  45              


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  


Leu Val Ile Thr Leu Tyr Cys 
65                  70      


<210>  242
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8-derived hinge and transmembrane domain

<400>  242

Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr 
65                  


<210>  243
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 hinge and transmembrane domain

<400>  243

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45              


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  


Leu Val Ile Thr 
65              


<210>  244
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)2 linker

<400>  244

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  245
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)3 linker

<400>  245

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  246
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)4 linker

<400>  246

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  247
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)5 linker

<400>  247

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210>  248
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  glycine linker

<400>  248

Gly Gly Gly Gly 
1               


<210>  249
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  glycine linker

<400>  249

Gly Gly Gly Gly Gly 
1               5   


<210>  250
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)2 linker

<400>  250

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  251
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v1

<400>  251

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Asp Leu Val 
        35                  40                  45              


Ser Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  252
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v2

<400>  252

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ser Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  253
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v3

<400>  253

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ser Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  254
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v4

<400>  254

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  255
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v5

<400>  255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  256
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v6

<400>  256

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  257
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v7

<400>  257

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  258
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v8

<400>  258

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ser Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  259
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v9

<400>  259

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ser Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  260
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v10

<400>  260

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ser Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  261
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v11

<400>  261

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ser Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  262
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v12

<400>  262

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  263
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v13

<400>  263

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Met Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  264
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v14

<400>  264

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  265
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v15

<400>  265

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  266
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v16

<400>  266

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  267
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hz18H10v17

<400>  267

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr Val Thr His Tyr Ala Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Tyr Thr Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Lys Pro 
        115 


<210>  268
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR1

<400>  268

Gly Ser Met Thr Gly Ala Asn Thr Met Gly 
1               5                   10  


<210>  269
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)3 linker

<400>  269

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  270
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)4 linker

<400>  270

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  271
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)5 linker

<400>  271

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210>  272
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR1

<400>  272

Gly Ser Val Thr Gly Ala Asn Thr Met Gly 
1               5                   10  


<210>  273
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR1

<400>  273

Gly Ser Ile Thr Gly Ala Asn Thr Met Gly 
1               5                   10  


<210>  274
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)2 linker

<400>  274

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  275
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)3 linker

<400>  275

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  276
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)4 linker

<400>  276

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  277
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)5 linker

<400>  277

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210>  278
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR2

<400>  278

Leu Ile Gly Asn Tyr Val Thr His 
1               5               


<210>  279
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)2 linker

<400>  279

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  280
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)3 linker

<400>  280

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  281
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)4 linker

<400>  281

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  282
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (GGS)5 linker

<400>  282

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210>  283
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR3

<400>  283

Tyr Thr Asp Asn Leu Gly Thr Ser 
1               5               


<210>  284
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  18H10

<400>  284

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Met Thr Gly Ala Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Leu Ile Gly Asn Tyr His Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Val Ile Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu Tyr Thr 
                85                  90                  95      


Asp Asn Leu Gly Thr Ser Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
            100                 105                 110         


Pro 
    


<210>  285
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 VL (CON)

<400>  285

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  286
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Homo sapiens

<400>  286

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  287
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<400>  287

Gly Gly Gly Gly Ala 
1               5   


<210>  288
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<400>  288

Gly Gly Gly Ala 
1               


<210>  289
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (6)..(10)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  May be present or absent
 
<400>  289

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  290
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  up to 11 amino acids may be absent

<220>
<221>  MISC_FEATURE
<222>  (14)..(25)
<223>  up to 11 amino acids may be absent

<400>  290

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25  


<210>  291
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(10)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (19)..(20)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (23)..(24)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (25)..(26)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (27)..(28)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (29)..(30)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (33)..(34)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (35)..(36)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (37)..(38)
<223>  May be present or absent

<220>
<221>  MISC_FEATURE
<222>  (39)..(40)
<223>  May be present or absent

<400>  291

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40  


<210>  292
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  292

Ile Glu Pro Asp Pro 
1               5   


<210>  293
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavable linker

<400>  293

Leu Glu Ala Asp Gly 
1               5   


<210>  294
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  substrate for granzyme B

<400>  294

Leu Glu Pro Gly 
1               


<210>  295
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  recombinant version of the human PD-1 extracellular domain

<400>  295

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Pro Ser Pro Ser Pro Arg Ser Ala Gly Gln Phe Gln 
    130                 135                 140             


<210>  296
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-8

<400>  296

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Thr Gln Tyr Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Tyr Thr Asp Tyr Val Val Tyr Arg Pro Gln Glu Ile Gly Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Lys Pro 
        115                 120             


<210>  297
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-14

<400>  297

Gln Leu Gln Leu Gln Gln Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Val Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Asn Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp His Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Glu Ser Ala Ala Gly Thr Leu Gly Asp Tyr Trp Gly Arg 
            100                 105                 110         


Gly Thr Gln Val Thr Val Lys Pro 
        115                 120 


<210>  298
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-13

<400>  298

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Glu Ile Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Asp Ser Val Ala Gly Thr Leu Gly Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Lys Pro 
        115                 120 


<210>  299
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-5

<400>  299

Gln Val Thr Leu Arg Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Gly Leu Tyr 
            20                  25                  30          


Ala Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ala Ser Arg Asp Asn Ala Lys Asp Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Tyr Glu Thr Arg Cys Asp Tyr Gly Leu Arg Leu Arg Asp 
            100                 105                 110         


Arg Thr Ala Tyr Trp Gly Pro Gly Thr Gln Val Thr Val Lys Pro 
        115                 120                 125         


<210>  300
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-8 CDR1

<400>  300

Gly Arg Thr Phe Ser Ser Tyr 
1               5           


<210>  301
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-14 CDR1

<400>  301

Gly Arg Thr Val Ser Ile Tyr 
1               5           


<210>  302
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-13 CDR2

<400>  302

Gly Arg Thr Glu Ile Ile Tyr 
1               5           


<210>  303
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-5 CDR1

<400>  303

Gly Leu Thr Phe Gly Leu Tyr 
1               5           


<210>  304
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-8 CDR2

<400>  304

Ser Trp Ser Gly Gly Thr 
1               5       


<210>  305
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-14 CDR2

<400>  305

Gly Trp Asn Gly Gly Thr 
1               5       


<210>  306
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-13 CDR2

<400>  306

Gly Trp Ser Gly Gly Thr 
1               5       


<210>  307
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-5 CDR2

<400>  307

Ser Asp Gly Ser Thr 
1               5   


<210>  308
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-8 CDR3

<400>  308

Tyr Thr Asp Tyr Val Val Tyr Arg Pro Gln Glu Ile Gly Tyr 
1               5                   10                  


<210>  309
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-14 CDR3

<400>  309

Gln Glu Ser Ala Ala Gly Thr Leu Gly Asp Tyr 
1               5                   10      


<210>  310
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-13 CDR3

<400>  310

Gln Asp Ser Val Ala Gly Thr Leu Gly Asp Tyr 
1               5                   10      


<210>  311
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cPD1-5 CDR3

<400>  311

Asp Tyr Glu Thr Arg Cys Asp Tyr Gly Leu Arg Leu Arg Asp Arg Thr 
1               5                   10                  15      


Ala Tyr 
        


<210>  312
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PD1 single domain antibody (PD-1 sdAb)

<400>  312

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Val Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Asn Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp His Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Glu Ser Ala Ala Gly Thr Leu Gly Asp Tyr Trp Gly Arg 
            100                 105                 110         


Gly Thr Gln Val Thr Val Lys Pro Gly Gly 
        115                 120         


<210>  313
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PD-1 sdAb CDR1

<400>  313

Gly Arg Thr Val Ser Ile Tyr Ala Met Gly 
1               5                   10  


<210>  314
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PD-1 sdAb CDR2

<400>  314

Gly Ile Gly Trp Asn Gly Gly Thr Thr Tyr 
1               5                   10  


<210>  315
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PD-1 sdAb CDR3

<400>  315

Glu Ser Ala Ala Gly Thr Leu Gly Asp Tyr 
1               5                   10  


<210>  316
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Anti-CD3 VH 312557

<400>  316

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Asp Ser Arg Gly Tyr Gly Asp Tyr Arg Leu Gly Gly Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  317
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Anti-CD3 VH 312557 G44C

<400>  317

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Asp Ser Arg Gly Tyr Gly Asp Tyr Arg Leu Gly Gly Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  318
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Anti-CD3 VL 312557

<400>  318

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  319
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Anti-CD3 VL 312557 Q100C

<400>  319

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  320
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD3-VH-G

<400>  320

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Gly Ser Gly Tyr Gly Lys Phe Tyr His Tyr Gly Leu Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  321
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD3-VH-G G44C

<400>  321

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Gly Ser Gly Tyr Gly Lys Phe Tyr His Tyr Gly Leu Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  322
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VK1-39Jkappa5

<400>  322

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  323
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VK1-39Jkappa5 Q100C

<400>  323

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Cys Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


