
                                SEQUENCE LISTING

<110> GENZYME CORPORATION

<120> GENERATION OF IMPROVED HUMAN PAH FOR TREATMENT OF SEVERE
      PKU BY LIVER-DIRECTED GENE REPLACEMENT THERAPY

<130> 15979-20166.40

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> US 62/744,944
<151> 2018-10-12

<160> 18

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 452
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser
 1               5                  10                  15      
Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn
            20                  25                  30          
Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu
        35                  40                  45              
Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His
    50                  55                  60                  
Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe
65                  70                  75                  80  
Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys
                85                  90                  95      
Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp
            100                 105                 110         
Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu
        115                 120                 125             
Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala
    130                 135                 140                 
Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln
145                 150                 155                 160 
Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg
                165                 170                 175     
Val Glu Tyr Met Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys
            180                 185                 190         
Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His
        195                 200                 205             
Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile
    210                 215                 220                 
Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe
225                 230                 235                 240 
Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly
                245                 250                 255     
Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly
            260                 265                 270         
Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu
        275                 280                 285             
Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln
    290                 295                 300                 
Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys
305                 310                 315                 320 
Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln
                325                 330                 335     
Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly
            340                 345                 350         
Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu
        355                 360                 365             
Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro
    370                 375                 380                 
Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg
385                 390                 395                 400 
Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro
                405                 410                 415     
Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile
            420                 425                 430         
Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu
        435                 440                 445             
Gln Lys Ile Lys
    450         


<210> 2
<211> 452
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser
 1               5                  10                  15      
Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn
            20                  25                  30          
Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu
        35                  40                  45              
Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His
    50                  55                  60                  
Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe
65                  70                  75                  80  
Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys
                85                  90                  95      
Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp
            100                 105                 110         
Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu
        115                 120                 125             
Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala
    130                 135                 140                 
Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln
145                 150                 155                 160 
Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg
                165                 170                 175     
Val Glu Tyr Met Glu Glu Gly Lys Lys Thr Trp Gly Thr Val Phe Lys
            180                 185                 190         
Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His
        195                 200                 205             
Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile
    210                 215                 220                 
Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe
225                 230                 235                 240 
Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly
                245                 250                 255     
Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly
            260                 265                 270         
Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu
        275                 280                 285             
Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln
    290                 295                 300                 
Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys
305                 310                 315                 320 
Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln
                325                 330                 335     
Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly
            340                 345                 350         
Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu
        355                 360                 365             
Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro
    370                 375                 380                 
Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg
385                 390                 395                 400 
Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro
                405                 410                 415     
Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile
            420                 425                 430         
Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu
        435                 440                 445             
Gln Lys Ile Lys
    450         


<210> 3
<211> 452
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser
 1               5                  10                  15      
Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn
            20                  25                  30          
Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu
        35                  40                  45              
Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His
    50                  55                  60                  
Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe
65                  70                  75                  80  
Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys
                85                  90                  95      
Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp
            100                 105                 110         
Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu
        115                 120                 125             
Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala
    130                 135                 140                 
Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln
145                 150                 155                 160 
Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg
                165                 170                 175     
Val Glu Tyr Thr Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys
            180                 185                 190         
Thr Leu Lys Ser Leu Tyr Pro Thr His Ala Cys Tyr Glu Tyr Asn His
        195                 200                 205             
Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile
    210                 215                 220                 
Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe
225                 230                 235                 240 
Arg Leu Arg Pro Val Ala Gly Leu Leu Pro Ser Arg Asp Phe Leu Ala
                245                 250                 255     
Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly
            260                 265                 270         
Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu
        275                 280                 285             
Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln
    290                 295                 300                 
Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys
305                 310                 315                 320 
Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln
                325                 330                 335     
Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly
            340                 345                 350         
Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu
        355                 360                 365             
Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro
    370                 375                 380                 
Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg
385                 390                 395                 400 
Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro
                405                 410                 415     
Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile
            420                 425                 430         
Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu
        435                 440                 445             
Gln Lys Ile Lys
    450         


<210> 4
<211> 1359
<212> DNA
<213> Homo sapiens

<400> 4
atgagcacag ccgtgctgga aaaccccggc ctgggcagaa agctgagcga cttcggccag 60
gaaaccagct acatcgagga caactgcaac cagaacggcg ccatcagcct gatcttcagc 120
ctgaaagaag aagtgggcgc cctggccaag gtgctgcggc tgttcgagga gaacgacgtg 180
aacctgaccc acatcgagag ccggcccagc agactgaaga aggacgagta cgagttcttc 240
acccacctgg acaagcggag cctgcccgcc ctgaccaaca tcatcaagat cctgcggcac 300
gacatcggcg ccaccgtgca cgagctgagc cgggacaaga aaaaggacac cgtgccctgg 360
ttccccagaa ccatccagga actggacaga ttcgccaacc agatcctgtc ctacggcgcc 420
gagctggatg ccgaccaccc tggcttcaag gaccccgtgt accgggccag acggaagcag 480
ttcgccgata tcgcctacaa ctaccggcac ggccagccca tccccagagt cgagtacacc 540
gaagagggca agaaaacctg gggcaccgtg ttcaagaccc tgaagtccct gtaccccacc 600
cacgcctgct acgagtacaa ccacatcttc ccactgctcg aaaagtactg cggcttccac 660
gaggacaata tccctcagct ggaggacgtg tcccagtttc tgcagacctg caccggcttc 720
agactcaggc ctgtggccgg cctgctgccc agcagagatt ttctggccgg actggccttc 780
cgggtgttcc actgcaccca gtacatcaga cacggcagca agcccatgta cacccctgag 840
cccgacatct gccacgagct gctgggacat gtgcccctgt tcagcgacag aagcttcgcc 900
cagttcagcc aggaaatcgg cctggcctct ctgggcgctc ccgacgagta tatcgagaag 960
ctggccacca tctactggtt caccgtggaa ttcggcctgt gcaagcaggg cgacagcatc 1020
aaggcctatg gcgccggact cctgtccagc ttcggcgagc tgcagtactg tctgagcgag 1080
aagcccaagc tgctgcccct ggaactggaa aagaccgcca tccagaacta caccgtgacc 1140
gagttccagc ccctgtacta cgtggccgag agcttcaacg acgccaaaga aaaagtgcgg 1200
aacttcgccg ccaccatccc tcggcccttc agcgtcagat acgaccccta cacccagcgg 1260
atcgaggtgc tggacaacac acagcagctg aaaattctgg ccgactccat caacagcgag 1320
atcggcatcc tgtgcagcgc cctgcagaaa atcaagtga                        1359

<210> 5
<211> 3713
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
gagctcttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag 60
gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagagag 120
ggagtggcca actccatcac taggggttcc tacgcgtggc cccaggttaa tttttaaaaa 180
gcagtcaaag gtcaaagtgg cccttggcag catttactct ctctattgac tttggttaat 240
aatctcagga gcacaaacat tcctggaggc aggagaagaa atcaacatcc tggacttatc 300
ctctgggcct ctccccacct tcgatggccc caggttaatt tttaaaaagc agtcaaaggt 360
caaagtggcc cttggcagca tttactctct ctattgactt tggttaataa tctcaggagc 420
acaaacattc ctggaggcag gagaagaaat caacatcctg gacttatcct ctgggcctct 480
ccccaccgat atctacctgc tgatcgcccg gcccctgttc aaacatgtcc taatactctg 540
tcggggcaaa ggtcggcagt agttttccat cttactcaac atcctcccag tgtacgtagg 600
atcctgtctg tctgcacatt tcgtagagcg agtgttccga tactctaatc tcccggggca 660
aaggtcgtat tgacttaggt tacttattct ccttttgttg actaagtcaa taatcagaat 720
cagcaggttt ggagtcagct tggcagggat cagcagcctg ggttggaagg agggggtata 780
aaagcccctt caccaggaga agccgtcaca cagatccaca agctcctgct agcagtcgct 840
gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc gccccggctc 900
tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc tccgggctgt 960
aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga aagccttgag 1020
gggctccggg aaggcccttt gtgcgggggg agcggctcgg ggggtgcgtg cgtgtgtgtg 1080
tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg ctgcgggcgc 1140
ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcggggccgg gggcggtgcc 1200
ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt gtgcgtgggg 1260
gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca cccccctccc 1320
cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg tggcgcgggg 1380
ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc ggggccgcct 1440
cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg cggctgtcga 1500
ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc gcagggactt 1560
cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac cccctctagc 1620
gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga gggccttcgt 1680
gcgtcgccgc gccgccgtcc ccttctccct ctccagcctc ggggctgtcc gcggggggac 1740
ggctgccttc gggggggacg gggcagggcg gggttcggct tctggcgtgt gaccggcggc 1800
tctagagcct ctgctaacca tgttcatgcc ttcttctttt tcctacagct cctgggcaac 1860
gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat tcatttcgaa gccgccacca 1920
tgagcacagc cgtgctggaa aaccccggcc tgggcagaaa gctgagcgac ttcggccagg 1980
aaaccagcta catcgaggac aactgcaacc agaacggcgc catcagcctg atcttcagcc 2040
tgaaagaaga agtgggcgcc ctggccaagg tgctgcggct gttcgaggag aacgacgtga 2100
acctgaccca catcgagagc cggcccagca gactgaagaa ggacgagtac gagttcttca 2160
cccacctgga caagcggagc ctgcccgccc tgaccaacat catcaagatc ctgcggcacg 2220
acatcggcgc caccgtgcac gagctgagcc gggacaagaa aaaggacacc gtgccctggt 2280
tccccagaac catccaggaa ctggacagat tcgccaacca gatcctgtcc tacggcgccg 2340
agctggatgc cgaccaccct ggcttcaagg accccgtgta ccgggccaga cggaagcagt 2400
tcgccgatat cgcctacaac taccggcacg gccagcccat ccccagagtc gagtacaccg 2460
aagagggcaa gaaaacctgg ggcaccgtgt tcaagaccct gaagtccctg taccccaccc 2520
acgcctgcta cgagtacaac cacatcttcc cactgctcga aaagtactgc ggcttccacg 2580
aggacaatat ccctcagctg gaggacgtgt cccagtttct gcagacctgc accggcttca 2640
gactcaggcc tgtggccggc ctgctgccca gcagagattt tctggccgga ctggccttcc 2700
gggtgttcca ctgcacccag tacatcagac acggcagcaa gcccatgtac acccctgagc 2760
ccgacatctg ccacgagctg ctgggacatg tgcccctgtt cagcgacaga agcttcgccc 2820
agttcagcca ggaaatcggc ctggcctctc tgggcgctcc cgacgagtat atcgagaagc 2880
tggccaccat ctactggttc accgtggaat tcggcctgtg caagcagggc gacagcatca 2940
aggcctatgg cgccggactc ctgtccagct tcggcgagct gcagtactgt ctgagcgaga 3000
agcccaagct gctgcccctg gaactggaaa agaccgccat ccagaactac accgtgaccg 3060
agttccagcc cctgtactac gtggccgaga gcttcaacga cgccaaagaa aaagtgcgga 3120
acttcgccgc caccatccct cggcccttca gcgtcagata cgacccctac acccagcgga 3180
tcgaggtgct ggacaacaca cagcagctga aaattctggc cgactccatc aacagcgaga 3240
tcggcatcct gtgcagcgcc ctgcagaaaa tcaagtgacc taggtgatca agatctgcta 3300
gcttaattaa cccgggacta gtgcggccgc tcgagactag tctgtgcctt ctagttgcca 3360
gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac 3420
tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat 3480
tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca 3540
tgctggggat gcggtgggct ctatggtacc aggaacccct agtgatggag ttggccactc 3600
cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg 3660
gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg gcc        3713

<210> 6
<211> 4561
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg 60
cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg 120
gccaactcca tcactagggg ttccttaccg cgtggcccca ggttaatttt taaaaagcag 180
tcaaaggtca aagtggccct tggcagcatt tactctctct attgactttg gttaataatc 240
tcaggagcac aaacattcct ggaggcagga gaagaaatca acatcctgga cttatcctct 300
gggcctctcc ccaccttcga tggccccagg ttaattttta aaaagcagtc aaaggtcaaa 360
gtggcccttg gcagcattta ctctctctat tgactttggt taataatctc aggagcacaa 420
acattcctgg aggcaggaga agaaatcaac atcctggact tatcctctgg gcctctcccc 480
accgatatct acctgctgat cgcccggccc ctgttcaaac atgtcctaat actctgtcgg 540
ggcaaaggtc ggcagtagtt ttccatctta ctcaacatcc tcccagtgta cgtaggatcc 600
tgtctgtctg cacatttcgt agagcgagtg ttccgatact ctaatctccc ggggcaaagg 660
tcgtattgac ttaggttact tattctcctt ttgttgacta agtcaataat cagaatcagc 720
aggtttggag tcagcttggc agggatcagc agcctgggtt ggaaggaggg ggtataaaag 780
ccccttcacc aggagaagcc gtcacacaga tccacaagct cctgctagcc aattgagtcg 840
ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc ctcgcgccgc ccgccccggc 900
tctgactgac cgcgttactc ccacaggtga gcgggcggga cggcccttct cctccgggct 960
gtaattagcg cttggtttat tgacggcttg tttcttttct gtggctgcgt gaaagccttg 1020
aggggctccg ggaaggccct ttgtgcgggg ggagcggctc ggggggtgcg tgcgtgtgtg 1080
tgtgcgtggg gagcgccgcg tgcggctccg cgctgcccgg cggctgtgag cgctgcgggc 1140
gcggcgcggg gctttgtgcg ctccgcagtg tgcgcgaggg gagcggggcc gggggcggtg 1200
ccccgcggtg cggggggggc tgcgagggga acaaaggctg cgtgcggggt gtgtgcgtgg 1260
gggggtgagc agggggtgtg ggcgcgtcgg tcgggctgca accccccctg cacccccctc 1320
cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtacgggg cgtggcgcgg 1380
ggctcgccgt gccgggcggg gggtggcggc aggtgggggt gccgggcggg gcggggccgc 1440
ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc ggcggctgtc 1500
gaggcgcggc gagccgcagc cattgccttt tttggtaatc gtgcgagagg gcgcagggac 1560
ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc accccctcta 1620
gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga attgggcggg gagggccttc 1680
gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt ccgcgggggg 1740
acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg 1800
gctctagagc ctctgctaac cttgttcttg ccttcttctt tttcctacag ctcctgggca 1860
acgtgctggt tattgtgctg tctcatcatt ttggcaaaga attcatttcg aagccgccac 1920
catgagcaca gccgtgctgg aaaaccccgg cctgggcaga aagctgagcg acttcggcca 1980
ggaaaccagc tacatcgagg acaactgcaa ccagaacggc gccatcagcc tgatcttcag 2040
cctgaaagaa gaagtgggcg ccctggccaa ggtgctgcgg ctgttcgagg agaacgacgt 2100
gaacctgacc cacatcgaga gccggcccag cagactgaag aaggacgagt acgagttctt 2160
cacccacctg gacaagcgga gcctgcccgc cctgaccaac atcatcaaga tcctgcggca 2220
cgacatcggc gccaccgtgc acgagctgag ccgggacaag aaaaaggaca ccgtgccctg 2280
gttccccaga accatccagg aactggacag attcgccaac cagatcctgt cctacggcgc 2340
cgagctggat gccgaccacc ctggcttcaa ggaccccgtg taccgggcca gacggaagca 2400
gttcgccgat atcgcctaca actaccggca cggccagccc atccccagag tcgagtacac 2460
cgaagagggc aagaaaacct ggggcaccgt gttcaagacc ctgaagtccc tgtaccccac 2520
ccacgcctgc tacgagtaca accacatctt cccactgctc gaaaagtact gcggcttcca 2580
cgaggacaat atccctcagc tggaggacgt gtcccagttt ctgcagacct gcaccggctt 2640
cagactcagg cctgtggccg gcctgctgcc cagcagagat tttctggccg gactggcctt 2700
ccgggtgttc cactgcaccc agtacatcag acacggcagc aagcccatgt acacccctga 2760
gcccgacatc tgccacgagc tgctgggaca tgtgcccctg ttcagcgaca gaagcttcgc 2820
ccagttcagc caggaaatcg gcctggcctc tctgggcgct cccgacgagt atatcgagaa 2880
gctggccacc atctactggt tcaccgtgga attcggcctg tgcaagcagg gcgacagcat 2940
caaggcctat ggcgccggac tcctgtccag cttcggcgag ctgcagtact gtctgagcga 3000
gaagcccaag ctgctgcccc tggaactgga aaagaccgcc atccagaact acaccgtgac 3060
cgagttccag cccctgtact acgtggccga gagcttcaac gacgccaaag aaaaagtgcg 3120
gaacttcgcc gccaccatcc ctcggccctt cagcgtcaga tacgacccct acacccagcg 3180
gatcgaggtg ctggacaaca cacagcagct gaaaattctg gccgactcca tcaacagcga 3240
gatcggcatc ctgtgcagcg ccctgcagaa aatcaagtga actagtctgt gccttctagt 3300
tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 3360
cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 3420
tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 3480
aggcatgctg gggatgcggt gggctctata ccggtccagg ggtgagtgaa ggtttggaag 3540
agtgtagcag aataagaaac catgagtccc ctccctgaga agccctgagc ccccttgacg 3600
acacacatcc ctcgaggctc agcttcatca tctgtaaaag gtgctgaaac tgaccatcca 3660
agctgccgaa aaagattgtg tggggataat tcaaaactag aggaagatgc agaatttcta 3720
catcgtggcg atgtcaggct aagagttgcc atcgtggctg tccatcgatt ttattggaat 3780
catatgttta tttgagggtg tcttggatat tacaaataaa ttgttggagc atcaggcata 3840
tttggtaatt ctgtctaagg ctccctgccc cttgttaatt ggcagctcag ttattcatcc 3900
agggcaaaca ttctgcttac tattcctgag agctttcctc atcctctaga ttggcagggg 3960
aattgcagtt gcctgagcag cctcccctct gccataccaa cagagcttca ccatcgaggc 4020
ttgcagagtg gacaggggcc tcagggaccc ctgatcccag ctttctcatt ggacagaagg 4080
aggagactgg ggctggagag ggacctgggc ccccactaag gccacagcag agccaggact 4140
ttagctgtgc tgactgcagc ctggcttgcc tccactgccc tcctttgcct caagagcaag 4200
ggagcctcag agtggaggaa gcagcccctg gccttgcctc ccacctcccc tcccctttgc 4260
tgttttcctg ggacagtggg agctggctta gattgccctg gggcccccag gaccctggca 4320
ttttaacccc tcaggggcag gaaggcagcc tgagatacag aagagtccat cacctgctgt 4380
atgccacaca ccatccccac agtcgacatt taaattagga acccctagtg atggagttgg 4440
ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 4500
gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 4560
a                                                                 4561

<210> 7
<211> 204
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
gcgagaactt gtgcctcccc gtgttcctga cctttgaccc tctgtcctac ttagactaat 60
attgactttg ggtactgcaa acaggaaatg ggggagggat tcgatgcgag aacttgtgcc 120
tccccgtgtt cctgaccttt gaccctctgt cctacttaga ctaatattga ctttgggtac 180
tgcaaacagg aaatggggga ggga                                        204

<210> 8
<211> 330
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
ggccccaggt taatttttaa aaagcagtca aaggtcaaag tggcccttgg cagcatttac 60
tctctctatt gactttggtt aataatctca ggagcacaaa cattcctgga ggcaggagaa 120
gaaatcaaca tcctggactt atcctctggg cctctcccca ccttcgatgg ccccaggtta 180
atttttaaaa agcagtcaaa ggtcaaagtg gcccttggca gcatttactc tctctattga 240
ctttggttaa taatctcagg agcacaaaca ttcctggagg caggagaaga aatcaacatc 300
ctggacttat cctctgggcc tctccccacc                                  330

<210> 9
<211> 377
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
gttcctagat tacattacac attctgcaag catagcacag gtcaaagttc aactttaatt 60
actttcattt tcttgtatcc tcacagccta gaaaataacc tgcgttacag catccactca 120
gtatcccttg agcatgaggt gacactactt aacataggga cgagatggta ctttgtgtct 180
cctgctctgt cagcagggca ctgtacttgc tgataccagg gaatattgat ttgtaaatac 240
catcattccg aacgtgtttg ccttggccag ttttccatgt acatgcagaa agaagtttgg 300
gactgatcaa tacagtcctc tgcctttaaa gcaataggaa aaggccaact tgtctacgtt 360
tagtatgtgg ctgtaga                                                377

<210> 10
<211> 156
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
ccatcagatc ctgcccaagg tcttacataa gaggactctt ggactcccag caatgtcaac 60
gaccgacctt gaggcctact tcaaagactg tgtgtttaag gactgggagg agctggggga 120
ggagattagg ttaaaggtct ttgtattagg aggctg                           156

<210> 11
<211> 71
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
ggggaggctg ctggtgaata ttaaccaagg tcaccccagt tatcggagga gcaaacaggg 60
gctaagtcca c                                                      71

<210> 12
<211> 869
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
ctcaattgga tgacactagt catcacattt aaaagcatct caggtaacta tattttgaat 60
tttttaaaaa agtaactata atagttatta ttaaaatagc aaagattgac catttccaag 120
agccatatag accagcaccg accactattc taaactattt atgtatgtaa atattagctt 180
ttaaaattct caaaatagtt gctgagttgg gaaccactat tatttctatc gattcagcag 240
ccgtaagtct aggacaggct taaattgttt tcactggtgt aaattgcaga aagatgatct 300
aagtaatttg gcatttattt taataggttt gaaaaacaca tgccatttta caaataagac 360
ttatatttgt ccttttgttt ttcagcctac catgagaata agagaaagaa aatgaagatc 420
aaaagcttat tcatctgttt ttctttttcg ttggtgtaaa gccaacaccc tgtctaaaaa 480
acataaattt ctttaatcat tttgcctctt ttctctgtgc ttcaattaat aaaaaatgga 540
aagaatctaa tagagtggta cagcactgtt atttttcaaa gatgtgttgc tatcctgaaa 600
attctgtagg ttctgtggaa gttccagtgt tctctcttat tccacttcgg tagaggattt 660
ctagtttctt gtgggctaat taaataaatc attaatactc ttctaagtta tggattataa 720
acattcaaaa taatattttg acattatgat aattctgaat aaaagaacaa aaaccatggt 780
ataggtaagg aatataaaac atggctttta ccttagaaaa aacaattcta aaattcatat 840
ggaatcaaaa aagagcctgc aggtaccct                                   869

<210> 13
<211> 1302
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
ctcaattgga tgacactagt catcacattt aaaagcatct caggtaacta tattttgaat 60
tttttaaaaa agtaactata atagttatta ttaaaatagc aaagattgac catttccaag 120
agccatatag accagcaccg accactattc taaactattt atgtatgtaa atattagctt 180
ttaaaattct caaaatagtt gctgagttgg gaaccactat tatttctatc tactgtttta 240
attaaaatta tctctaaggc atgtgaactg gctgtcttgg ttttcatctg tacttcatct 300
gctacctctg tgacctgaaa catatttata attccattaa gctgtgcata tgatagattt 360
atcatatgta ttttccttaa aggatttttg taagaactaa ttgaattgat acctgtaaag 420
tctttatcac actacccaat aaataataaa tctctttgtt cagctctctg tttctataaa 480
tatgtaccag ttttattgtt tttagtggta gtgattttat tctctttcta tatatataca 540
cacacatgtg tgcattcata aatatataca atttttatga ataaaaaatt attagcaatc 600
aatattgaaa accactgatt tttgtttatg tgagcaaaca gcagattaaa aggaattcct 660
gcagattcag cagccgtaag tctaggacag gcttaaattg ttttcactgg tgtaaattgc 720
agaaagatga tctaagtaat ttggcattta ttttaatagg tttgaaaaac acatgccatt 780
ttacaaataa gacttatatt tgtccttttg tttttcagcc taccatgaga ataagagaaa 840
gaaaatgaag atcaaaagct tattcatctg tttttctttt tcgttggtgt aaagccaaca 900
ccctgtctaa aaaacataaa tttctttaat cattttgcct cttttctctg tgcttcaatt 960
aataaaaaat ggaaagaatc taatagagtg gtacagcact gttatttttc aaagatgtgt 1020
tgctatcctg aaaattctgt aggttctgtg gaagttccag tgttctctct tattccactt 1080
cggtagagga tttctagttt cttgtgggct aattaaataa atcattaata ctcttctaag 1140
ttatggatta taaacattca aaataatatt ttgacattat gataattctg aataaaagaa 1200
caaaaaccat ggtataggta aggaatataa aacatggctt ttaccttaga aaaaacaatt 1260
ctaaaattca tatggaatca aaaaagagcc tgcaggtacc ct                    1302

<210> 14
<211> 1359
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
atgagcacag ccgtgctgga aaaccccggc ctgggcagaa agctgagcga cttcggccag 60
gaaaccagct acatcgagga caactgcaac cagaacggcg ccatcagcct gatcttcagc 120
ctgaaagaag aagtgggcgc cctggccaag gtgctgcggc tgttcgaaga gaacgacgtg 180
aacctgaccc acatcgagag ccggcccagc agactgaaga aggacgagta cgagttcttc 240
acccacctgg acaagcggag cctgcccgcc ctgaccaaca tcatcaagat cctgcggcac 300
gacatcggcg ccaccgtgca cgagctgagc cgggacaaga aaaaggacac cgtgccctgg 360
ttccccagaa ccatccagga actggacaga ttcgccaacc agatcctgtc ctacggcgcc 420
gagctggatg ccgaccaccc tggcttcaag gaccccgtgt accgggccag acggaagcag 480
ttcgccgata tcgcctacaa ctaccggcac ggccagccca tccccagagt cgagtacatg 540
gaagagggca agaaaacctg gggcaccgtg ttcaagaccc tgaagtccct gtacaagacc 600
cacgcctgct acgagtacaa ccacatcttc ccactgctcg agaagtactg cggcttccac 660
gaggacaata tccctcagct cgaggacgtg tcccagtttc tgcagacctg caccggcttc 720
agactcaggc ctgtggccgg cctgctgagc agcagagatt ttctgggcgg actggccttc 780
cgggtgttcc actgcaccca gtacatcaga cacggcagca agcccatgta cacccctgag 840
cccgacatct gccacgagct gctgggacat gtgcccctgt tcagcgacag aagcttcgcc 900
cagttcagcc aggaaatcgg cctggcctct ctgggcgctc ccgacgagta tatcgagaag 960
ctggccacca tctactggtt caccgtggaa ttcggcctgt gcaagcaggg cgacagcatc 1020
aaggcctatg gcgccggact cctgtccagc ttcggcgagc tgcagtactg tctgagcgag 1080
aagcccaagc tgctgcccct ggaactggaa aagaccgcca tccagaacta caccgtgacc 1140
gagttccagc ccctgtacta cgtggccgag agcttcaacg acgccaaaga aaaagtgcgg 1200
aacttcgccg ccaccatccc tcggcccttc agcgtcagat acgaccccta cacccagcgg 1260
atcgaggtgc tggacaacac acagcagctg aaaattctgg ccgactccat caacagcgag 1320
atcggcatcc tgtgcagcgc cctgcagaaa atcaagtga                        1359

<210> 15
<211> 1069
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
agtcgctgcg cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc 60
ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc 120
gggctgtaat tagcgcttgg tttattgacg gcttgtttct tttctgtggc tgcgtgaaag 180
ccttgagggg ctccgggaag gccctttgtg cggggggagc ggctcggggg gtgcgtgcgt 240
gtgtgtgtgc gtggggagcg ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg 300
cgggcgcggc gcggggcttt gtgcgctccg cagtgtgcgc gaggggagcg gggccggggg 360
cggtgccccg cggtgcgggg ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg 420
cgtggggggg tgagcagggg gtgtgggcgc gtcggtcggg ctgcaacccc ccctgcaccc 480
ccctccccga gttgctgagc acggcccggc ttcgggtgcg gggctccgta cggggcgtgg 540
cgcggggctc gccgtgccgg gcggggggtg gcggcaggtg ggggtgccgg gcggggcggg 600
gccgcctcgg gccggggagg gctcggggga ggggcgcggc ggcccccgga gcgccggcgg 660
ctgtcgaggc gcggcgagcc gcagccattg ccttttttgg taatcgtgcg agagggcgca 720
gggacttcct ttgtcccaaa tctgtgcgga gccgaaatct gggaggcgcc gccgcacccc 780
ctctagcggg cgcggggcga agcggtgcgg cgccggcagg aaggaattgg gcggggaggg 840
ccttcgtgcg tcgccgcgcc gccgtcccct tctccctctc cagcctcggg gctgtccgcg 900
gggggacggc tgccttcggg ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac 960
cggcggctct agagcctctg ctaaccttgt tcttgccttc ttctttttcc tacagctcct 1020
gggcaacgtg ctggttattg tgctgtctca tcattttggc aaagaattc             1069

<210> 16
<211> 901
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
ccaggggtga gtgaaggttt ggaagagtgt agcagaataa gaaaccatga gtcccctccc 60
tgagaagccc tgagccccct tgacgacaca catccctcga ggctcagctt catcatctgt 120
aaaaggtgct gaaactgacc atccaagctg ccgaaaaaga ttgtgtgggg ataattcaaa 180
actagaggaa gatgcagaat ttctacatcg tggcgatgtc aggctaagag ttgccatcgt 240
ggctgtccat cgattttatt ggaatcatat gtttatttga gggtgtcttg gatattacaa 300
ataaattgtt ggagcatcag gcatatttgg taattctgtc taaggctccc tgccccttgt 360
taattggcag ctcagttatt catccagggc aaacattctg cttactattc ctgagagctt 420
tcctcatcct ctagattggc aggggaattg cagttgcctg agcagcctcc cctctgccat 480
accaacagag cttcaccatc gaggcttgca gagtggacag gggcctcagg gacccctgat 540
cccagctttc tcattggaca gaaggaggag actggggctg gagagggacc tgggccccca 600
ctaaggccac agcagagcca ggactttagc tgtgctgact gcagcctggc ttgcctccac 660
tgccctcctt tgcctcaaga gcaagggagc ctcagagtgg aggaagcagc ccctggcctt 720
gcctcccacc tcccctcccc tttgctgttt tcctgggaca gtgggagctg gcttagattg 780
ccctggggcc cccaggaccc tggcatttta acccctcagg ggcaggaagg cagcctgaga 840
tacagaagag tccatcacct gctgtatgcc acacaccatc cccacagtcg acatttaaat 900
t                                                                 901

<210> 17
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccacgc 60
ccgggctttg cccgggcg                                               78

<210> 18
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp
 1               5                  10                  15      
Tyr Lys Asp Asp Asp Asp Lys
            20              

