                               SEQUENCE LISTING

<110> AMICUS THERAPEUTICS, INC.
 
<120> DISULFIDE BOND STABILIZED POLYPEPTIDE COMPOSITIONS AND 
      METHODS OF USE

<130> 36003-704.601

<140> PCT/US2019/055679
<141> 2019-10-10

<150> 62/744,069
<151> 2018-10-10

<160> 34    

<170> PatentIn version 3.5

<210> 1
<211> 429
<212> PRT
<213> Homo sapiens

<400> 1
Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210> 2
<211> 429
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Cys Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Cys Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210> 3
<211> 429
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Cys Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Cys Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210> 4
<211> 429
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Cys Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Cys Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210> 5
<211> 429
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Cys Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Cys Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210> 6
<211> 429
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Cys Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210> 7
<211> 1290
<212> DNA
<213> Homo sapiens

<400> 7
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggaca atggattggc aaggacgcct      120

accatgggct ggctgcactg ggagcgcttc atgtgcaacc ttgactgcca ggaagagcca      180

gattcctgca tcagtgagaa gctcttcatg gagatggcag agctcatggt ctcagaaggc      240

tggaaggatg caggttatga gtacctctgc attgatgact gttggatggc tccccaaaga      300

gattcagaag gcagacttca ggcagaccct cagcgctttc ctcatgggat tcgccagcta      360

gctaattatg ttcacagcaa aggactgaag ctagggattt atgcagatgt tggaaataaa      420

acctgcgcag gcttccctgg gagttttgga tactacgaca ttgatgccca gacctttgct      480

gactggggag tagatctgct aaaatttgat ggttgttact gtgacagttt ggaaaatttg      540

gcagatggtt ataagcacat gtccttggcc ctgaatagga ctggcagaag cattgtgtac      600

tcctgtgagt ggcctcttta tatgtggccc tttcaaaagc ccaattatac agaaatccga      660

cagtactgca atcactggcg aaattttgct gacattgatg attcctggaa aagtataaag      720

agtatcttgg actggacatc ttttaaccag gagagaattg ttgatgttgc tggaccaggg      780

ggttggaatg acccagatat gttagtgatt ggcaactttg gcctcagctg gaatcagcaa      840

gtaactcaga tggccctctg ggctatcatg gctgctcctt tattcatgtc taatgacctc      900

cgacacatca gccctcaagc caaagctctc cttcaggata aggacgtaat tgccatcaat      960

caggacccct tgggcaagca agggtaccag cttagacagg gagacaactt tgaagtgtgg     1020

gaacgacctc tctcaggctt agcctgggct gtagctatga taaaccggca ggagattggt     1080

ggacctcgct cttataccat cgcagttgct tccctgggta aaggagtggc ctgtaatcct     1140

gcctgcttca tcacacagct cctccctgtg aaaaggaagc tagggttcta tgaatggact     1200

tcaaggttaa gaagtcacat aaatcccaca ggcactgttt tgcttcagct agaaaataca     1260

atgcagatgt cattaaaaga cttactttaa                                      1290


<210> 8
<211> 1290
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggaca atggattggc aaggacgcct      120

accatgggct ggctgcactg ggagtgcttc atgtgcaacc ttgactgcca ggaagagcca      180

gattcctgca tcagtgagaa gctcttcatg gagatggcag agctcatggt ctcagaaggc      240

tggaaggatg caggttatga gtacctctgc attgatgact gttggatggc tccccaaaga      300

gattcagaag gcagacttca ggcagaccct cagcgctttc ctcatgggat tcgccagcta      360

gctaattatg ttcacagcaa aggactgaag ctagggattt atgcagatgt tggaaataaa      420

acctgcgcag gcttccctgg gagttttgga tactacgaca ttgatgccca gacctttgct      480

gactggggag tagatctgct aaaatttgat ggttgttact gtgacagttt ggaaaatttg      540

gcagatggtt ataagcacat gtccttggcc ctgaatagga ctggcagaag cattgtgtac      600

tcctgtgagt ggcctcttta tatgtggccc tttcaaaagc ccaattatac agaaatccga      660

cagtactgca atcactggcg aaattttgct gacattgatg attcctggaa aagtataaag      720

agtatcttgg actggacatc ttttaaccag gagagaattg ttgatgttgc tggaccaggg      780

ggttggaatg acccagatat gttagtgatt ggcaactttg gcctcagctg gaatcagcaa      840

gtaactcaga tggccctctg ggctatcatg gctgctcctt tattcatgtc taatgacctc      900

cgacacatca gccctcaagc caaagctctc cttcaggata aggacgtaat tgccatcaat      960

caggacccct tgggcaagca agggtaccag cttagacagg gagacaactt tgaagtgtgg     1020

gaacgacctc tctcaggctt agcctgggct gtagctatga taaaccggca ggagattggt     1080

tgccctcgct cttataccat cgcagttgct tccctgggta aaggagtggc ctgtaatcct     1140

gcctgcttca tcacacagct cctccctgtg aaaaggaagc tagggttcta tgaatggact     1200

tcaaggttaa gaagtcacat aaatcccaca ggcactgttt tgcttcagct agaaaataca     1260

atgcagatgt cattaaaaga cttactttaa                                      1290


<210> 9
<211> 1290
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 9
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggaca atggattggc aaggacgcct      120

accatgggct ggctgcactg ggagtgcttc atgtgcaacc ttgactgcca ggaagagcca      180

gattcctgca tcagtgagaa gctcttcatg gagatggcag agctcatggt ctcagaaggc      240

tggaaggatg caggttatga gtacctctgc attgatgact gttggatggc tccccaaaga      300

gattcagaag gcagacttca ggcagaccct cagcgctttc ctcatgggat tcgccagcta      360

gctaattatg ttcacagcaa aggactgaag ctagggattt atgcagatgt tggaaataaa      420

acctgcgcag gcttccctgg gagttttgga tactacgaca ttgatgccca gacctttgct      480

gactggggag tagatctgct aaaatttgat ggttgttact gtgacagttt ggaaaatttg      540

gcagatggtt ataagcacat gtccttggcc ctgaatagga ctggcagaag cattgtgtac      600

tcctgtgagt ggcctcttta tatgtggccc tttcaaaagc ccaattatac agaaatccga      660

cagtactgca atcactggcg aaattttgct gacattgatg attcctggaa aagtataaag      720

agtatcttgg actggacatc ttttaaccag gagagaattg ttgatgttgc tggaccaggg      780

ggttggaatg acccagatat gttagtgatt ggcaactttg gcctcagctg gaatcagcaa      840

gtaactcaga tggccctctg ggctatcatg gctgctcctt tattcatgtc taatgacctc      900

cgacacatca gccctcaagc caaagctctc cttcaggata aggacgtaat tgccatcaat      960

caggacccct tgggcaagca agggtaccag cttagacagg gagacaactt tgaagtgtgg     1020

gaacgacctc tctcaggctt agcctgggct gtagctatga taaaccggca ggagatttgt     1080

ggacctcgct cttataccat cgcagttgct tccctgggta aaggagtggc ctgtaatcct     1140

gcctgcttca tcacacagct cctccctgtg aaaaggaagc tagggttcta tgaatggact     1200

tcaaggttaa gaagtcacat aaatcccaca ggcactgttt tgcttcagct agaaaataca     1260

atgcagatgt cattaaaaga cttactttaa                                      1290


<210> 10
<211> 1290
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggaca atggattggc aaggacgcct      120

accatgggct ggctgcactg ggagcgcttc tgctgcaacc ttgactgcca ggaagagcca      180

gattcctgca tcagtgagaa gctcttcatg gagatggcag agctcatggt ctcagaaggc      240

tggaaggatg caggttatga gtacctctgc attgatgact gttggatggc tccccaaaga      300

gattcagaag gcagacttca ggcagaccct cagcgctttc ctcatgggat tcgccagcta      360

gctaattatg ttcacagcaa aggactgaag ctagggattt atgcagatgt tggaaataaa      420

acctgcgcag gcttccctgg gagttttgga tactacgaca ttgatgccca gacctttgct      480

gactggggag tagatctgct aaaatttgat ggttgttact gtgacagttt ggaaaatttg      540

gcagatggtt ataagcacat gtccttggcc ctgaatagga ctggcagaag cattgtgtac      600

tcctgtgagt ggcctcttta tatgtggccc tttcaaaagc ccaattatac agaaatccga      660

cagtactgca atcactggcg aaattttgct gacattgatg attcctggaa aagtataaag      720

agtatcttgg actggacatc ttttaaccag gagagaattg ttgatgttgc tggaccaggg      780

ggttggaatg acccagatat gttagtgatt ggcaactttg gcctcagctg gaatcagcaa      840

gtaactcaga tggccctctg ggctatcatg gctgctcctt tattcatgtc taatgacctc      900

cgacacatca gccctcaagc caaagctctc cttcaggata aggacgtaat tgccatcaat      960

caggacccct tgggcaagca agggtaccag cttagacagg gagacaactt tgaagtgtgg     1020

gaacgacctc tctcaggctt agcctgggct gtagctatga taaaccggca ggagatttgt     1080

ggacctcgct cttataccat cgcagttgct tccctgggta aaggagtggc ctgtaatcct     1140

gcctgcttca tcacacagct cctccctgtg aaaaggaagc tagggttcta tgaatggact     1200

tcaaggttaa gaagtcacat aaatcccaca ggcactgttt tgcttcagct agaaaataca     1260

atgcagatgt cattaaaaga cttactttaa                                      1290


<210> 11
<211> 1290
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggaca atggattggc aaggacgcct      120

accatgggct ggctgcactg ggagcgcttc atgtgcaacc ttgactgcca ggaagagcca      180

gattcctgca tcagtgagaa gctcttcatg gagatggcag agctcatggt ctcagaaggc      240

tggaaggatg caggttatga gtacctctgc attgatgact gttggatggc tccccaaaga      300

gattcagaag gcagacttca ggcagaccct cagcgctttc ctcatgggat tcgccagcta      360

gctaattatg ttcacagcaa aggactgaag ctagggattt atgcagatgt tggaaataaa      420

acctgcgcag gcttccctgg gagttttgga tactacgaca ttgatgccca gacctttgct      480

gactggggag tagatctgct aaaatttgat ggttgttact gtgacagttt ggaaaatttg      540

gcagatggtt ataagcacat gtccttggcc ctgaatagga ctggcagaag cattgtgtac      600

tcctgtgagt ggcctcttta tatgtggccc tttcaaaagc ccaattatac agaaatccga      660

cagtactgca atcactggcg aaattttgct gacatttgcg attcctggaa aagtataaag      720

agtatcttgg actggacatc ttttaaccag gagagaattg ttgatgttgc tggaccaggg      780

ggttggaatg acccagatat gttagtgatt ggcaactttg gcctcagctg gaatcagcaa      840

gtaactcaga tggccctctg ggctatcatg gctgctcctt tattcatgtc taatgacctc      900

cgacacatca gccctcaagc caaagctctc cttcaggata aggacgtaat tgccatcaat      960

caggacccct tgggcaagca agggtaccag cttagacagg gagacaactt tgaagtgtgg     1020

gaacgacctc tctcaggctt agcctgggct gtagctatga taaaccggca ggagtgcggt     1080

ggacctcgct cttataccat cgcagttgct tccctgggta aaggagtggc ctgtaatcct     1140

gcctgcttca tcacacagct cctccctgtg aaaaggaagc tagggttcta tgaatggact     1200

tcaaggttaa gaagtcacat aaatcccaca ggcactgttt tgcttcagct agaaaataca     1260

atgcagatgt cattaaaaga cttactttaa                                      1290


<210> 12
<211> 1290
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 12
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggaca atggattggc aaggacgcct      120

accatgggct ggctgcactg ggagcgcttc atgtgcaacc ttgactgcca ggaagagcca      180

gattcctgca tcagtgagaa gctcttcatg gagatggcag agctcatggt ctcagaaggc      240

tggaaggatg caggttatga gtacctctgc attgatgact gttggatggc tccccaaaga      300

gattcagaag gcagacttca ggcagaccct cagcgctttc ctcatgggat tcgccagcta      360

gctaattatg ttcacagcaa aggactgaag ctagggattt atgcagatgt tggaaataaa      420

acctgcgcag gcttccctgg gagttttgga tactacgaca ttgatgccca gacctttgct      480

gactggggag tagatctgct aaaatttgat ggttgttact gtgacagttt ggaaaatttg      540

gcagatggtt ataagcacat gtccttggcc ctgaatagga ctggcagaag cattgtgtac      600

tcctgtgagt ggcctcttta tatgtggccc tttcaaaagc ccaattatac agaaatccga      660

cagtactgca atcactggcg aaattttgct gacattgatg attcctggaa aagtataaag      720

agtatcttgg actggacatc ttttaaccag gagagaattg ttgatgttgc tggaccaggg      780

ggttggaatg acccagatat gttagtgatt ggcaactttg gcctctgctg gaatcagcaa      840

gtaactcaga tggccctctg ggctatcatg gctgctcctt tattcatgtc taatgacctc      900

cgacacatca gccctcaagc caaagctctc cttcaggata aggacgtaat tgccatcaat      960

caggacccct tgggcaagca agggtaccag cttagacagg gagacaactt tgaagtgtgg     1020

gaacgacctc tctcaggctt agcctgggct gtagctatga taaaccggca ggagattggt     1080

ggacctcgct cttataccat cgcagttgct tccctgggta aaggagtggc ctgtaatcct     1140

gcctgcttca tcacacagct cctccctgtg aaaaggaagc tagggttcta tgaatggact     1200

tcaaggttaa gaagtcacat aaatcccaca ggcactgttt tgcttcagct agaaaataca     1260

atgcagatgt cattaaaaga cttactttaa                                      1290


<210> 13
<211> 306
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210> 14
<211> 306
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Cys Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Cys Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210> 15
<211> 2504
<212> DNA
<213> Homo sapiens

<400> 15
ttattttgat tcaccgcaga gggcggtcta cgagagcgca gagccccact cggccagcgg       60

ggtctggcgg gggacctgtc gcgctgaaag ctccagggta gggccgacgc ccatcaggct      120

gggcatccgt tcgggatgcg caggttgcga tctgcaaccg gcggcgccac gcccaggcgg      180

gcggagcgcg gttcccggag tctcgcgccc gcggtcatgt gacacagcga agatggcgtc      240

gcccggctgc ctgtggctct tggctgtggc tctcctgcca tggacctgcg cttctcgggc      300

gctgcagcat ctggacccgc cggcgccgct gccgttggtg atctggcatg ggatgggaga      360

cagctgttgc aatcccttaa gcatgggtgc tattaaaaaa atggtggaga agaaaatacc      420

tggaatttac gtcttatctt tagagattgg gaagaccctg atggaggacg tggagaacag      480

cttcttcttg aatgtcaatt cccaagtaac aacagtgtgt caggcacttg ctaaggatcc      540

taaattgcag caaggctaca atgctatggg attctcccag ggaggccaat ttctgagggc      600

agtggctcag agatgccctt cacctcccat gatcaatctg atctcggttg ggggacaaca      660

tcaaggtgtt tttggactcc ctcgatgccc aggagagagc tctcacatct gtgacttcat      720

ccgaaaaaca ctgaatgctg gggcgtactc caaagttgtt caggaacgcc tcgtgcaagc      780

cgaatactgg catgacccca taaaggagga tgtgtatcgc aaccacagca tcttcttggc      840

agatataaat caggagcggg gtatcaatga gtcctacaag aaaaacctga tggccctgaa      900

gaagtttgtg atggtgaaat tcctcaatga ttccattgtg gaccctgtag attcggagtg      960

gtttggattt tacagaagtg gccaagccaa ggaaaccatt cccttacagg agacctccct     1020

gtacacacag gaccgcctgg ggctaaagga aatggacaat gcaggacagc tagtgtttct     1080

ggctacagaa ggggaccatc ttcagttgtc tgaagaatgg ttttatgccc acatcatacc     1140

attccttgga tgaaacccgt atagttcaca atagagctca gggagcccct aactcttcca     1200

aaccacatgg gagacagttt ccttcatgcc caagcctgag ctcagatcca gcttgcaact     1260

aatccttcta tcatctaaca tgccctactt ggaaagatct aagatctgaa tcttatcctt     1320

tgccatcttc tgttaccata tggtgttgaa tgcaagttta attaccatgg agattgtttt     1380

acaaactttt gatgtggtca agttcagttt tagaaaaggg agtctgttcc agatcagtgc     1440

cagaactgtg cccaggccca aaggagacaa ctaactaaag tagtgagata gattctaagg     1500

gcaaacattt ttccaagtct tgccatattt caagcaaaga ggtgcccagg cctgaggtac     1560

tcacataaat gctttgtttt gctggtgatt taaccagtgc ttggaaaaat cttgcttggc     1620

tatttctgca tcatttctta aggctgcctt cctctctcag tacgttgccc tctgtgctat     1680

catcttatca tcaattatta gacaaatccc actggcctac agtcttgctt ctgcagcacc     1740

cactttgtct cctcaggtag tgatgaatta gttgctgtca caaaaggagg gaagtagcac     1800

ccaaattaag ttgcttaaga gaggaaatgt acatcttgta taacttaggg agcgaagaaa     1860

atgtaggcgc gaaagtgaaa agtgaggcag ctagttcttc ctattccatt ctcgaccaac     1920

ctgccctttc ttaatatgac tagtggtctt gatgctagag tcaacttact ctgttgctgg     1980

ctttagcaga gaataggagg aaccatatga aaaagatcag gctttctgac ttccatcccc     2040

aaaacacatt taccagcata ctccaaactg tttctgatgt gttccatgag aaaaggattg     2100

tttgctcaaa aagcttggaa aatactacac actccctttc tccttctgga gatcaaccca     2160

cattagagtg tctaaggact cctgagaatt cctgttacag taaacaaaac taacgtaatc     2220

taccatttcc tacactattt gagcatggaa atcatagtcc ccactctgtg aaaacttaac     2280

gctttttgga agacatttct gtagcatgtc agtttggaga aatgatgagc tacgccttga     2340

tgaaagaacc gtgttggtgc tgctaagttt agccattatg gtttttcctt tctctctctt     2400

aagccttatt cttcaactaa aagatgagga ttaagagcaa gaagttgggg gggatgtgaa     2460

aataatttta tgaggttgtc taaaataaag agtagtttct tatc                      2504


<210> 16
<211> 921
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 16
atggcatcac cgggttgcct ctggttgttg gccgttgcgt tgcttccgtg gacatgtgca       60

tcaagagctc ttcaacatct ggatccccca gctcccctgc cgctcgtaat ctggcacggg      120

atgggggatt catgttgtaa cccgttgtca atgggcgcga taaaaaagat ggttgaaaag      180

aagattccag gcatctacgt tctgtccctg gaaatcggta agacactgat ggaagacgtg      240

gagaactcct tctttctcaa cgtcaatagt caggtcacta ccgtctgtca agcattggca      300

aaggacccta aacttcagca ggggtacaat gcgatggggt ttagccaggg cggacagttt      360

cttagagccg tcgcacagcg ctgtccatct cccccgatga ttaaccttat atctgtcggg      420

ggacaacacc agggtgtttt tggtcttcct cgctgtcctg gtgaaagctc ccacatctgt      480

gatttcatac gcaaaacgtt gaacgcagga tgctatagta aagtcgtcca agaacggctt      540

gttcaatgcg agtattggca tgacccaata aaagaagacg tttataggaa tcactctatc      600

ttcttggccg atatcaacca agaacgcgga atcaacgaaa gctacaaaaa gaatcttatg      660

gctctcaaga aatttgttat ggtgaaattc cttaatgact ctatagtaga tcctgtcgat      720

tcagaatggt tcgggttcta caggtctggc caggcgaagg agactattcc cctccaagaa      780

acgtctctct atacacaaga cagactcgga ctgaaagaga tggataatgc gggccagttg      840

gtcttcttgg ctacggaagg cgatcatctc caactctccg aagagtggtt ctatgcccat      900

ataatcccgt tcctgggcta a                                                921


<210> 17
<211> 67
<212> PRT
<213> Homo sapiens

<400> 17
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 18
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Ser Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 19
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 20
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 21
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Thr 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 22
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Ser Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 23
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ile Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 24
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Arg Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 25
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Arg Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 26
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Ser Leu Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Leu Glu Glu Cys Cys Thr 
        35                  40                  45              


Ser Ile Cys Asp Leu Arg Arg Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210> 27
<211> 61
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly 
1               5                   10                  15      


Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg 
            20                  25                  30          


Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala 
        35                  40                  45              


Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60      


<210> 28
<211> 274
<212> RNA
<213> Cricket paralysis virus

<400> 28
cggugucgaa guagaauuuc uaucucgaca cgcggccuuc caagcaguua gggaaaccga       60

cuucuuugaa gaagaaagcu gacuauguga ucuuauuaaa auuagguuaa auuucgaggu      120

uaaaaauagu uuuaauauug cuauagucuu agaggucuug uauauuuaua cuuaccacac      180

aagauggacc ggagcagccc uccaauaucu aguguacccu cgugcucgcu caaacauuaa      240

gugguguugu gcgaaaagaa ucucacuuca agaa                                  274


<210> 29
<211> 18
<212> PRT
<213> Homo sapiens

<400> 29
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala 
        


<210> 30
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Ala Ala Met Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25              


<210> 31
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Trp Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25  


<210> 32
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Ala Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25      


<210> 33
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Ala Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25      


<210> 34
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 34
gccrccaugg                                                              10


