                         SEQUENCE LISTING

<110>  THE CLEVELAND CLINIC FOUNDATION
 
<120>  AGGF1 AND AGGF1-PRIMED CELLS FOR TREATING DISEASES AND CONDITIONS

<130>  CCF-36962.601

<150>  US 62/744,488
<151>  2018-10-11

<150>  US 62/842,283
<151>  2019-05-02

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Glu Ala Pro Ser Pro Pro Arg Ser Pro Pro Pro Pro Thr 
1               5                   10                  15      


Ser Pro Glu Pro Glu Leu Ala Gln Leu Arg Arg Lys Val Glu Lys Leu 
            20                  25                  30          


Glu Arg Glu Leu Arg Ser Cys Lys Arg Gln Val Arg Glu Ile Glu Lys 
        35                  40                  45              


Leu Leu His His Thr Glu Arg Leu Tyr Gln Asn Ala Glu Ser Asn Asn 
    50                  55                  60                  


Gln Glu Leu Arg Thr Gln Val Glu Glu Leu Ser Lys Ile Leu Gln Arg 
65                  70                  75                  80  


Gly Arg Asn Glu Asp Asn Lys Lys Ser Asp Val Glu Val Gln Thr Glu 
                85                  90                  95      


Asn His Ala Pro Trp Ser Ile Ser Asp Tyr Phe Tyr Gln Thr Tyr Tyr 
            100                 105                 110         


Asn Asp Val Ser Leu Pro Asn Lys Val Thr Glu Leu Ser Asp Gln Gln 
        115                 120                 125             


Asp Gln Ala Ile Glu Thr Ser Ile Leu Asn Ser Lys Asp His Leu Gln 
    130                 135                 140                 


Val Glu Asn Asp Ala Tyr Pro Gly Thr Asp Arg Thr Glu Asn Val Lys 
145                 150                 155                 160 


Tyr Arg Gln Val Asp His Phe Ala Ser Asn Ser Gln Glu Pro Ala Ser 
                165                 170                 175     


Ala Leu Ala Thr Glu Asp Thr Ser Leu Glu Gly Ser Ser Leu Ala Glu 
            180                 185                 190         


Ser Leu Arg Ala Ala Ala Glu Ala Ala Val Ser Gln Thr Gly Phe Ser 
        195                 200                 205             


Tyr Asp Glu Asn Thr Gly Leu Tyr Phe Asp His Ser Thr Gly Phe Tyr 
    210                 215                 220                 


Tyr Asp Ser Glu Asn Gln Leu Tyr Tyr Asp Pro Ser Thr Gly Ile Tyr 
225                 230                 235                 240 


Tyr Tyr Cys Asp Val Glu Ser Gly Arg Tyr Gln Phe His Ser Arg Val 
                245                 250                 255     


Asp Leu Gln Pro Tyr Pro Thr Ser Ser Thr Lys Gln Ser Lys Asp Lys 
            260                 265                 270         


Lys Leu Lys Lys Lys Arg Lys Asp Pro Asp Ser Ser Ala Thr Asn Glu 
        275                 280                 285             


Glu Lys Asp Leu Asn Ser Glu Asp Gln Lys Ala Phe Ser Val Glu His 
    290                 295                 300                 


Thr Ser Cys Asn Glu Glu Glu Asn Phe Ala Asn Met Lys Lys Lys Ala 
305                 310                 315                 320 


Lys Ile Gly Ile His His Lys Asn Ser Pro Pro Lys Val Thr Val Pro 
                325                 330                 335     


Thr Ser Gly Asn Thr Ile Glu Ser Pro Leu His Glu Asn Ile Ser Asn 
            340                 345                 350         


Ser Thr Ser Phe Lys Asp Glu Lys Ile Met Glu Thr Asp Ser Glu Pro 
        355                 360                 365             


Glu Glu Gly Glu Ile Thr Asp Ser Gln Thr Glu Asp Ser Tyr Asp Glu 
    370                 375                 380                 


Ala Ile Thr Ser Glu Gly Asn Val Thr Ala Glu Asp Ser Glu Asp Glu 
385                 390                 395                 400 


Asp Glu Asp Lys Ile Trp Pro Pro Cys Ile Arg Val Ile Val Ile Arg 
                405                 410                 415     


Ser Pro Val Leu Gln Ile Gly Ser Leu Phe Ile Ile Thr Ala Val Asn 
            420                 425                 430         


Pro Ala Thr Ile Gly Arg Glu Lys Asp Met Glu His Thr Leu Arg Ile 
        435                 440                 445             


Pro Glu Val Gly Val Ser Lys Phe His Ala Glu Ile Tyr Phe Asp His 
    450                 455                 460                 


Asp Leu Gln Ser Tyr Val Leu Val Asp Gln Gly Ser Gln Asn Gly Thr 
465                 470                 475                 480 


Ile Val Asn Gly Lys Gln Ile Leu Gln Pro Lys Thr Lys Cys Asp Pro 
                485                 490                 495     


Tyr Val Leu Glu His Gly Asp Glu Val Lys Ile Gly Glu Thr Val Leu 
            500                 505                 510         


Ser Phe His Ile His Pro Gly Ser Asp Thr Cys Asp Gly Cys Glu Pro 
        515                 520                 525             


Gly Gln Val Arg Ala His Leu Arg Leu Asp Lys Lys Asp Glu Ser Phe 
    530                 535                 540                 


Val Gly Pro Thr Leu Ser Lys Glu Glu Lys Glu Leu Glu Arg Arg Lys 
545                 550                 555                 560 


Glu Leu Lys Lys Ile Arg Val Lys Tyr Gly Leu Gln Asn Thr Glu Tyr 
                565                 570                 575     


Glu Asp Glu Lys Thr Leu Lys Asn Pro Lys Tyr Lys Asp Arg Ala Gly 
            580                 585                 590         


Lys Arg Arg Glu Gln Val Gly Ser Glu Gly Thr Phe Gln Arg Asp Asp 
        595                 600                 605             


Ala Pro Ala Ser Val His Ser Glu Ile Thr Asp Ser Asn Lys Gly Arg 
    610                 615                 620                 


Lys Met Leu Glu Lys Met Gly Trp Lys Lys Gly Glu Gly Leu Gly Lys 
625                 630                 635                 640 


Asp Gly Gly Gly Met Lys Thr Pro Ile Gln Leu Gln Leu Arg Arg Thr 
                645                 650                 655     


His Ala Gly Leu Gly Thr Gly Lys Pro Ser Ser Phe Glu Asp Val His 
            660                 665                 670         


Leu Leu Gln Asn Lys Asn Lys Lys Asn Trp Asp Lys Ala Arg Glu Arg 
        675                 680                 685             


Phe Thr Glu Asn Phe Pro Glu Thr Lys Pro Gln Lys Asp Asp Pro Gly 
    690                 695                 700                 


Thr Met Pro Trp Val Lys Gly Thr Leu Glu 
705                 710                 


<210>  2
<211>  696
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Glu Leu Ala Gln Leu Arg Arg Lys Val Glu Lys Leu Glu Arg 
1               5                   10                  15      


Glu Leu Arg Ser Cys Lys Arg Gln Val Arg Glu Ile Glu Lys Leu Leu 
            20                  25                  30          


His His Thr Glu Arg Leu Tyr Gln Asn Ala Glu Ser Asn Asn Gln Glu 
        35                  40                  45              


Leu Arg Thr Gln Val Glu Glu Leu Ser Lys Ile Leu Gln Arg Gly Arg 
    50                  55                  60                  


Asn Glu Asp Asn Lys Lys Ser Asp Val Glu Val Gln Thr Glu Asn His 
65                  70                  75                  80  


Ala Pro Trp Ser Ile Ser Asp Tyr Phe Tyr Gln Thr Tyr Tyr Asn Asp 
                85                  90                  95      


Val Ser Leu Pro Asn Lys Val Thr Glu Leu Ser Asp Gln Gln Asp Gln 
            100                 105                 110         


Ala Ile Glu Thr Ser Ile Leu Asn Ser Lys Asp His Leu Gln Val Glu 
        115                 120                 125             


Asn Asp Ala Tyr Pro Gly Thr Asp Arg Thr Glu Asn Val Lys Tyr Arg 
    130                 135                 140                 


Gln Val Asp His Phe Ala Ser Asn Ser Gln Glu Pro Ala Ser Ala Leu 
145                 150                 155                 160 


Ala Thr Glu Asp Thr Ser Leu Glu Gly Ser Ser Leu Ala Glu Ser Leu 
                165                 170                 175     


Arg Ala Ala Ala Glu Ala Ala Val Ser Gln Thr Gly Phe Ser Tyr Asp 
            180                 185                 190         


Glu Asn Thr Gly Leu Tyr Phe Asp His Ser Thr Gly Phe Tyr Tyr Asp 
        195                 200                 205             


Ser Glu Asn Gln Leu Tyr Tyr Asp Pro Ser Thr Gly Ile Tyr Tyr Tyr 
    210                 215                 220                 


Cys Asp Val Glu Ser Gly Arg Tyr Gln Phe His Ser Arg Val Asp Leu 
225                 230                 235                 240 


Gln Pro Tyr Pro Thr Ser Ser Thr Lys Gln Ser Lys Asp Lys Lys Leu 
                245                 250                 255     


Lys Lys Lys Arg Lys Asp Pro Asp Ser Ser Ala Thr Asn Glu Glu Lys 
            260                 265                 270         


Asp Leu Asn Ser Glu Asp Gln Lys Ala Phe Ser Val Glu His Thr Ser 
        275                 280                 285             


Cys Asn Glu Glu Glu Asn Phe Ala Asn Met Lys Lys Lys Ala Lys Ile 
    290                 295                 300                 


Gly Ile His His Lys Asn Ser Pro Pro Lys Val Thr Val Pro Thr Ser 
305                 310                 315                 320 


Gly Asn Thr Ile Glu Ser Pro Leu His Glu Asn Ile Ser Asn Ser Thr 
                325                 330                 335     


Ser Phe Lys Asp Glu Lys Ile Met Glu Thr Asp Ser Glu Pro Glu Glu 
            340                 345                 350         


Gly Glu Ile Thr Asp Ser Gln Thr Glu Asp Ser Tyr Asp Glu Ala Ile 
        355                 360                 365             


Thr Ser Glu Gly Asn Val Thr Ala Glu Asp Ser Glu Asp Glu Asp Glu 
    370                 375                 380                 


Asp Lys Ile Trp Pro Pro Cys Ile Arg Val Ile Val Ile Arg Ser Pro 
385                 390                 395                 400 


Val Leu Gln Ile Gly Ser Leu Phe Ile Ile Thr Ala Val Asn Pro Ala 
                405                 410                 415     


Thr Ile Gly Arg Glu Lys Asp Met Glu His Thr Leu Arg Ile Pro Glu 
            420                 425                 430         


Val Gly Val Ser Lys Phe His Ala Glu Ile Tyr Phe Asp His Asp Leu 
        435                 440                 445             


Gln Ser Tyr Val Leu Val Asp Gln Gly Ser Gln Asn Gly Thr Ile Val 
    450                 455                 460                 


Asn Gly Lys Gln Ile Leu Gln Pro Lys Thr Lys Cys Asp Pro Tyr Val 
465                 470                 475                 480 


Leu Glu His Gly Asp Glu Val Lys Ile Gly Glu Thr Val Leu Ser Phe 
                485                 490                 495     


His Ile His Pro Gly Ser Asp Thr Cys Asp Gly Cys Glu Pro Gly Gln 
            500                 505                 510         


Val Arg Ala His Leu Arg Leu Asp Lys Lys Asp Glu Ser Phe Val Gly 
        515                 520                 525             


Pro Thr Leu Ser Lys Glu Glu Lys Glu Leu Glu Arg Arg Lys Glu Leu 
    530                 535                 540                 


Lys Lys Ile Arg Val Lys Tyr Gly Leu Gln Asn Thr Glu Tyr Glu Asp 
545                 550                 555                 560 


Glu Lys Thr Leu Lys Asn Pro Lys Tyr Lys Asp Arg Ala Gly Lys Arg 
                565                 570                 575     


Arg Glu Gln Val Gly Ser Glu Gly Thr Phe Gln Arg Asp Asp Ala Pro 
            580                 585                 590         


Ala Ser Val His Ser Glu Ile Thr Asp Ser Asn Lys Gly Arg Lys Met 
        595                 600                 605             


Leu Glu Lys Met Gly Trp Lys Lys Gly Glu Gly Leu Gly Lys Asp Gly 
    610                 615                 620                 


Gly Gly Met Lys Thr Pro Ile Gln Leu Gln Leu Arg Arg Thr His Ala 
625                 630                 635                 640 


Gly Leu Gly Thr Gly Lys Pro Ser Ser Phe Glu Asp Val His Leu Leu 
                645                 650                 655     


Gln Asn Lys Asn Lys Lys Asn Trp Asp Lys Ala Arg Glu Arg Phe Thr 
            660                 665                 670         


Glu Asn Phe Pro Glu Thr Lys Pro Gln Lys Asp Asp Pro Gly Thr Met 
        675                 680                 685             


Pro Trp Val Lys Gly Thr Leu Glu 
    690                 695     


<210>  3
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Lys Ser Asp Val Glu Val Gln Thr Glu Asn His Ala Pro Trp 
1               5                   10                  15      


Ser Ile Ser Asp Tyr Phe Tyr Gln Thr Tyr Tyr Asn Asp Val Ser Leu 
            20                  25                  30          


Pro Asn Lys Val Thr Glu Leu Ser Asp Gln Gln Asp Gln Ala Ile Glu 
        35                  40                  45              


Thr Ser Ile Leu Asn Ser Lys Asp His Leu Gln Val Glu Asn Asp Ala 
    50                  55                  60                  


Tyr Pro Gly Thr Asp Arg Thr Glu Asn Val Lys Tyr Arg Gln Val Asp 
65                  70                  75                  80  


His Phe Ala Ser Asn Ser Gln Glu Pro Ala Ser Ala Leu Ala Thr Glu 
                85                  90                  95      


Asp Thr Ser Leu Glu Gly Ser Ser Leu Ala Glu Ser Leu Arg Ala Ala 
            100                 105                 110         


Ala Glu Ala Ala Val Ser Gln Thr Gly Phe Ser Tyr Asp Glu Asn Thr 
        115                 120                 125             


Gly Leu Tyr Phe Asp His Ser Thr Gly Phe Tyr Tyr Asp Ser Glu Asn 
    130                 135                 140                 


Gln Leu Tyr Tyr Asp Pro Ser Thr Gly Ile Tyr Tyr Tyr Cys Asp Val 
145                 150                 155                 160 


Glu Ser Gly Arg Tyr Gln Phe His Ser Arg Val Asp Leu Gln Pro Tyr 
                165                 170                 175     


Pro Thr Ser Ser Thr Lys Gln Ser Lys Asp Lys Lys Leu Lys Lys Lys 
            180                 185                 190         


Arg Lys Asp Pro Asp Ser Ser Ala Thr Asn Glu Glu Lys Asp Leu Asn 
        195                 200                 205             


Ser Glu Asp Gln Lys Ala Phe Ser Val Glu His Thr Ser Cys Asn Glu 
    210                 215                 220                 


Glu Glu Asn Phe Ala Asn Met Lys Lys Lys Ala Lys Ile Gly Ile His 
225                 230                 235                 240 


His Lys Asn Ser Pro Pro Lys Val Thr Val Pro Thr Ser Gly Asn Thr 
                245                 250                 255     


Ile Glu Ser Pro Leu His Glu Asn Ile Ser Asn Ser Thr Ser Phe Lys 
            260                 265                 270         


Asp Glu Lys Ile Met Glu Thr Asp Ser Glu Pro Glu Glu Gly Glu Ile 
        275                 280                 285             


Thr Asp Ser Gln Thr Glu Asp Ser Tyr Asp Glu Ala Ile Thr Ser Glu 
    290                 295                 300                 


Gly Asn Val Thr Ala Glu Asp Ser Glu Asp Glu Asp Glu Asp Lys Ile 
305                 310                 315                 320 


Trp Pro Pro Cys Ile Arg Val Ile Val Ile Arg Ser Pro Val Leu Gln 
                325                 330                 335     


Ile Gly Ser Leu Phe Ile Ile Thr Ala Val Asn Pro Ala Thr Ile Gly 
            340                 345                 350         


Arg Glu Lys Asp Met Glu His Thr Leu Arg Ile Pro Glu Val Gly Val 
        355                 360                 365             


Ser Lys Phe His Ala Glu Ile Tyr Phe Asp His Asp Leu Gln Ser Tyr 
    370                 375                 380                 


Val Leu Val Asp Gln Gly Ser Gln Asn Gly Thr Ile Val Asn Gly Lys 
385                 390                 395                 400 


Gln Ile Leu Gln Pro Lys Thr Lys Cys Asp Pro Tyr Val Leu Glu His 
                405                 410                 415     


Gly Asp Glu Val Lys Ile Gly Glu Thr Val Leu Ser Phe His Ile His 
            420                 425                 430         


Pro Gly Ser Asp Thr Cys Asp Gly Cys Glu Pro Gly Gln Val Arg Ala 
        435                 440                 445             


His Leu Arg Leu Asp Lys Lys Asp Glu Ser Phe Val Gly Pro Thr Leu 
    450                 455                 460                 


Ser Lys Glu Glu Lys Glu Leu Glu Arg Arg Lys Glu Leu Lys Lys Ile 
465                 470                 475                 480 


Arg Val Lys Tyr Gly Leu Gln Asn Thr Glu Tyr Glu Asp Glu Lys Thr 
                485                 490                 495     


Leu Lys Asn Pro Lys Tyr Lys Asp Arg Ala Gly Lys Arg Arg Glu Gln 
            500                 505                 510         


Val Gly Ser Glu Gly Thr Phe Gln Arg Asp Asp Ala Pro Ala Ser Val 
        515                 520                 525             


His Ser Glu Ile Thr Asp Ser Asn Lys Gly Arg Lys Met Leu Glu Lys 
    530                 535                 540                 


Met Gly Trp Lys Lys Gly Glu Gly Leu Gly Lys Asp Gly Gly Gly Met 
545                 550                 555                 560 


Lys Thr Pro Ile Gln Leu Gln Leu Arg Arg Thr His Ala Gly Leu Gly 
                565                 570                 575     


Thr Gly Lys Pro Ser Ser Phe Glu Asp Val His Leu Leu Gln Asn Lys 
            580                 585                 590         


Asn Lys Lys Asn Trp Asp Lys Ala Arg Glu Arg Phe Thr Glu Asn Phe 
        595                 600                 605             


Pro Glu Thr Lys Pro Gln Lys Asp Asp Pro Gly Thr Met Pro Trp Val 
    610                 615                 620                 


Lys Gly Thr Leu Glu 
625                 


<210>  4
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  4

Met His Phe Ala Ser Asn Ser Gln Glu Pro Ala Ser Ala Leu Ala Thr 
1               5                   10                  15      


Glu Asp Thr Ser Leu Glu Gly Ser Ser Leu Ala Glu Ser Leu Arg Ala 
            20                  25                  30          


Ala Ala Glu Ala Ala Val Ser Gln Thr Gly Phe Ser Tyr Asp Glu Asn 
        35                  40                  45              


Thr Gly Leu Tyr Phe Asp His Ser Thr Gly Phe Tyr Tyr Asp Ser Glu 
    50                  55                  60                  


Asn Gln Leu Tyr Tyr Asp Pro Ser Thr Gly Ile Tyr Tyr Tyr Cys Asp 
65                  70                  75                  80  


Val Glu Ser Gly Arg Tyr Gln Phe His Ser Arg Val Asp Leu Gln Pro 
                85                  90                  95      


Tyr Pro Thr Ser Ser Thr Lys Gln Ser Lys Asp Lys Lys Leu Lys Lys 
            100                 105                 110         


Lys Arg Lys Asp Pro Asp Ser Ser Ala Thr Asn Glu Glu Lys Asp Leu 
        115                 120                 125             


Asn Ser Glu Asp Gln Lys Ala Phe Ser Val Glu His Thr Ser Cys Asn 
    130                 135                 140                 


Glu Glu Glu Asn Phe Ala Asn Met Lys Lys Lys Ala Lys Ile Gly Ile 
145                 150                 155                 160 


His His Lys Asn Ser Pro Pro Lys Val Thr Val Pro Thr Ser Gly Asn 
                165                 170                 175     


Thr Ile Glu Ser Pro Leu His Glu Asn Ile Ser Asn Ser Thr Ser Phe 
            180                 185                 190         


Lys Asp Glu Lys Ile Met Glu Thr Asp Ser Glu Pro Glu Glu Gly Glu 
        195                 200                 205             


Ile Thr Asp Ser Gln Thr Glu Asp Ser Tyr Asp Glu Ala Ile Thr Ser 
    210                 215                 220                 


Glu Gly Asn Val Thr Ala Glu Asp Ser Glu Asp Glu Asp Glu Asp Lys 
225                 230                 235                 240 


Ile Trp Pro Pro Cys Ile Arg Val Ile Val Ile Arg Ser Pro Val Leu 
                245                 250                 255     


Gln Ile Gly Ser Leu Phe Ile Ile Thr Ala Val Asn Pro Ala Thr Ile 
            260                 265                 270         


Gly Arg Glu Lys Asp Met Glu His Thr Leu Arg Ile Pro Glu Val Gly 
        275                 280                 285             


Val Ser Lys Phe His Ala Glu Ile Tyr Phe Asp His Asp Leu Gln Ser 
    290                 295                 300                 


Tyr Val Leu Val Asp Gln Gly Ser Gln Asn Gly Thr Ile Val Asn Gly 
305                 310                 315                 320 


Lys Gln Ile Leu Gln Pro Lys Thr Lys Cys Asp Pro Tyr Val Leu Glu 
                325                 330                 335     


His Gly Asp Glu Val Lys Ile Gly Glu Thr Val Leu Ser Phe His Ile 
            340                 345                 350         


His Pro Gly Ser Asp Thr Cys Asp Gly Cys Glu Pro Gly Gln Val Arg 
        355                 360                 365             


Ala His Leu Arg Leu Asp Lys Lys Asp Glu Ser Phe Val Gly Pro Thr 
    370                 375                 380                 


Leu Ser Lys Glu Glu Lys Glu Leu Glu Arg Arg Lys Glu Leu Lys Lys 
385                 390                 395                 400 


Ile Arg Val Lys Tyr Gly Leu Gln Asn Thr Glu Tyr Glu Asp Glu Lys 
                405                 410                 415     


Thr Leu Lys Asn Pro Lys Tyr Lys Asp Arg Ala Gly Lys Arg Arg Glu 
            420                 425                 430         


Gln Val Gly Ser Glu Gly Thr Phe Gln Arg Asp Asp Ala Pro Ala Ser 
        435                 440                 445             


Val His Ser Glu Ile Thr Asp Ser Asn Lys Gly Arg Lys Met Leu Glu 
    450                 455                 460                 


Lys Met Gly Trp Lys Lys Gly Glu Gly Leu Gly Lys Asp Gly Gly Gly 
465                 470                 475                 480 


Met Lys Thr Pro Ile Gln Leu Gln Leu Arg Arg Thr His Ala Gly Leu 
                485                 490                 495     


Gly Thr Gly Lys Pro Ser Ser Phe Glu Asp Val His Leu Leu Gln Asn 
            500                 505                 510         


Lys Asn Lys Lys Asn Trp Asp Lys Ala Arg Glu Arg Phe Thr Glu Asn 
        515                 520                 525             


Phe Pro Glu Thr Lys Pro Gln Lys Asp Asp Pro Gly Thr Met Pro Trp 
    530                 535                 540                 


Val Lys Gly Thr Leu Glu 
545                 550 


<210>  5
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Thr Gly Phe Tyr Tyr Asp Ser Glu Asn Gln Leu Tyr Tyr Asp 
1               5                   10                  15      


Pro Ser Thr Gly Ile Tyr Tyr Tyr Cys Asp Val Glu Ser Gly Arg Tyr 
            20                  25                  30          


Gln Phe His Ser Arg Val Asp Leu Gln Pro Tyr Pro Thr Ser Ser Thr 
        35                  40                  45              


Lys Gln Ser Lys Asp Lys Lys Leu Lys Lys Lys Arg Lys Asp Pro Asp 
    50                  55                  60                  


Ser Ser Ala Thr Asn Glu Glu Lys Asp Leu Asn Ser Glu Asp Gln Lys 
65                  70                  75                  80  


Ala Phe Ser Val Glu His Thr Ser Cys Asn Glu Glu Glu Asn Phe Ala 
                85                  90                  95      


Asn Met Lys Lys Lys Ala Lys Ile Gly Ile His His Lys Asn Ser Pro 
            100                 105                 110         


Pro Lys Val Thr Val Pro Thr Ser Gly Asn Thr Ile Glu Ser Pro Leu 
        115                 120                 125             


His Glu Asn Ile Ser Asn Ser Thr Ser Phe Lys Asp Glu Lys Ile Met 
    130                 135                 140                 


Glu Thr Asp Ser Glu Pro Glu Glu Gly Glu Ile Thr Asp Ser Gln Thr 
145                 150                 155                 160 


Glu Asp Ser Tyr Asp Glu Ala Ile Thr Ser Glu Gly Asn Val Thr Ala 
                165                 170                 175     


Glu Asp Ser Glu Asp Glu Asp Glu Asp Lys Ile Trp Pro Pro Cys Ile 
            180                 185                 190         


Arg Val Ile Val Ile Arg Ser Pro Val Leu Gln Ile Gly Ser Leu Phe 
        195                 200                 205             


Ile Ile Thr Ala Val Asn Pro Ala Thr Ile Gly Arg Glu Lys Asp Met 
    210                 215                 220                 


Glu His Thr Leu Arg Ile Pro Glu Val Gly Val Ser Lys Phe His Ala 
225                 230                 235                 240 


Glu Ile Tyr Phe Asp His Asp Leu Gln Ser Tyr Val Leu Val Asp Gln 
                245                 250                 255     


Gly Ser Gln Asn Gly Thr Ile Val Asn Gly Lys Gln Ile Leu Gln Pro 
            260                 265                 270         


Lys Thr Lys Cys Asp Pro Tyr Val Leu Glu His Gly Asp Glu Val Lys 
        275                 280                 285             


Ile Gly Glu Thr Val Leu Ser Phe His Ile His Pro Gly Ser Asp Thr 
    290                 295                 300                 


Cys Asp Gly Cys Glu Pro Gly Gln Val Arg Ala His Leu Arg Leu Asp 
305                 310                 315                 320 


Lys Lys Asp Glu Ser Phe Val Gly Pro Thr Leu Ser Lys Glu Glu Lys 
                325                 330                 335     


Glu Leu Glu Arg Arg Lys Glu Leu Lys Lys Ile Arg Val Lys Tyr Gly 
            340                 345                 350         


Leu Gln Asn Thr Glu Tyr Glu Asp Glu Lys Thr Leu Lys Asn Pro Lys 
        355                 360                 365             


Tyr Lys Asp Arg Ala Gly Lys Arg Arg Glu Gln Val Gly Ser Glu Gly 
    370                 375                 380                 


Thr Phe Gln Arg Asp Asp Ala Pro Ala Ser Val His Ser Glu Ile Thr 
385                 390                 395                 400 


Asp Ser Asn Lys Gly Arg Lys Met Leu Glu Lys Met Gly Trp Lys Lys 
                405                 410                 415     


Gly Glu Gly Leu Gly Lys Asp Gly Gly Gly Met Lys Thr Pro Ile Gln 
            420                 425                 430         


Leu Gln Leu Arg Arg Thr His Ala Gly Leu Gly Thr Gly Lys Pro Ser 
        435                 440                 445             


Ser Phe Glu Asp Val His Leu Leu Gln Asn Lys Asn Lys Lys Asn Trp 
    450                 455                 460                 


Asp Lys Ala Arg Glu Arg Phe Thr Glu Asn Phe Pro Glu Thr Lys Pro 
465                 470                 475                 480 


Gln Lys Asp Asp Pro Gly Thr Met Pro Trp Val Lys Gly Thr Leu Glu 
                485                 490                 495     


<210>  6
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Thr Asn Glu Glu Lys Asp Leu Asn Ser Glu Asp Gln Lys Ala 
1               5                   10                  15      


Phe Ser Val Glu His Thr Ser Cys Asn Glu Glu Glu Asn Phe Ala Asn 
            20                  25                  30          


Met Lys Lys Lys Ala Lys Ile Gly Ile His His Lys Asn Ser Pro Pro 
        35                  40                  45              


Lys Val Thr Val Pro Thr Ser Gly Asn Thr Ile Glu Ser Pro Leu His 
    50                  55                  60                  


Glu Ile Ser Asn Ser Thr Ser Phe Lys Asp Glu Lys Ile Met Glu Thr 
65                  70                  75                  80  


Asp Ser Glu Pro Glu Glu Gly Glu Ile Thr Asp Ser Gln Thr Glu Asp 
                85                  90                  95      


Ser Tyr Asp Glu Ala Ile Thr Ser Glu Gly Asn Val Thr Ala Glu Asp 
            100                 105                 110         


Ser Glu Asp Glu Asp Glu Asp Lys Ile Trp Pro Pro Cys Ile Arg Val 
        115                 120                 125             


Ile Val Ile Arg Ser Pro Val Leu Gln Ile Gly Ser Leu Phe Ile Ile 
    130                 135                 140                 


Thr Ala Val Asn Pro Ala Thr Ile Gly Arg Glu Lys Asp Met Glu His 
145                 150                 155                 160 


Thr Leu Arg Ile Pro Glu Val Gly Val Ser Lys Phe His Ala Glu Ile 
                165                 170                 175     


Tyr Phe Asp His Asp Leu Gln Ser Tyr Val Leu Val Asp Gln Gly Ser 
            180                 185                 190         


Gln Asn Gly Thr Ile Val Asn Gly Lys Gln Ile Leu Gln Pro Lys Thr 
        195                 200                 205             


Lys Cys Asp Pro Tyr Val Leu Glu His Gly Asp Glu Val Lys Ile Gly 
    210                 215                 220                 


Glu Thr Val Leu Ser Phe His Ile His Pro Gly Ser Asp Thr Cys Asp 
225                 230                 235                 240 


Gly Cys Glu Pro Gly Gln Val Arg Ala His Leu Arg Leu Asp Lys Lys 
                245                 250                 255     


Asp Glu Ser Phe Val Gly Pro Thr Leu Ser Lys Glu Glu Lys Glu Leu 
            260                 265                 270         


Glu Arg Arg Lys Glu Leu Lys Lys Ile Arg Val Lys Tyr Gly Leu Gln 
        275                 280                 285             


Asn Thr Glu Tyr Glu Asp Glu Lys Thr Leu Lys Asn Pro Lys Tyr Lys 
    290                 295                 300                 


Asp Arg Ala Gly Lys Arg Arg Glu Gln Val Gly Ser Glu Gly Thr Phe 
305                 310                 315                 320 


Gln Arg Asp Asp Ala Pro Ala Ser Val His Ser Glu Ile Thr Asp Ser 
                325                 330                 335     


Asn Lys Gly Arg Lys Met Leu Glu Lys Met Gly Trp Lys Lys Gly Glu 
            340                 345                 350         


Gly Leu Gly Lys Asp Gly Gly Gly Met Lys Thr Pro Ile Gln Leu Gln 
        355                 360                 365             


Leu Arg Arg Thr His Ala Gly Leu Gly Thr Gly Lys Pro Ser Ser Phe 
    370                 375                 380                 


Glu Asp Val His Leu Leu Gln Asn Lys Asn Lys Lys Asn Trp Asp Lys 
385                 390                 395                 400 


Ala Arg Glu Arg Phe Thr Glu Asn Phe Pro Glu Thr Lys Pro Gln Lys 
                405                 410                 415     


Asp Asp Pro Gly Thr Met Pro Trp Val Lys Gly Thr Leu Glu 
            420                 425                 430 


<210>  7
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ile Ser Asn Ser Thr Ser Phe Lys Asp Glu Lys Ile Met Glu Thr 
1               5                   10                  15      


Asp Ser Glu Pro Glu Glu Gly Glu Ile Thr Asp Ser Gln Thr Glu Asp 
            20                  25                  30          


Ser Tyr Asp Glu Ala Ile Thr Ser Glu Gly Asn Val Thr Ala Glu Asp 
        35                  40                  45              


Ser Glu Asp Glu Asp Glu Asp Lys Ile Trp Pro Pro Cys Ile Arg Val 
    50                  55                  60                  


Ile Val Ile Arg Ser Pro Val Leu Gln Ile Gly Ser Leu Phe Ile Ile 
65                  70                  75                  80  


Thr Ala Val Asn Pro Ala Thr Ile Gly Arg Glu Lys Asp Met Glu His 
                85                  90                  95      


Thr Leu Arg Ile Pro Glu Val Gly Val Ser Lys Phe His Ala Glu Ile 
            100                 105                 110         


Tyr Phe Asp His Asp Leu Gln Ser Tyr Val Leu Val Asp Gln Gly Ser 
        115                 120                 125             


Gln Asn Gly Thr Ile Val Asn Gly Lys Gln Ile Leu Gln Pro Lys Thr 
    130                 135                 140                 


Lys Cys Asp Pro Tyr Val Leu Glu His Gly Asp Glu Val Lys Ile Gly 
145                 150                 155                 160 


Glu Thr Val Leu Ser Phe His Ile His Pro Gly Ser Asp Thr Cys Asp 
                165                 170                 175     


Gly Cys Glu Pro Gly Gln Val Arg Ala His Leu Arg Leu Asp Lys Lys 
            180                 185                 190         


Asp Glu Ser Phe Val Gly Pro Thr Leu Ser Lys Glu Glu Lys Glu Leu 
        195                 200                 205             


Glu Arg Arg Lys Glu Leu Lys Lys Ile Arg Val Lys Tyr Gly Leu Gln 
    210                 215                 220                 


Asn Thr Glu Tyr Glu Asp Glu Lys Thr Leu Lys Asn Pro Lys Tyr Lys 
225                 230                 235                 240 


Asp Arg Ala Gly Lys Arg Arg Glu Gln Val Gly Ser Glu Gly Thr Phe 
                245                 250                 255     


Gln Arg Asp Asp Ala Pro Ala Ser Val His Ser Glu Ile Thr Asp Ser 
            260                 265                 270         


Asn Lys Gly Arg Lys Met Leu Glu Lys Met Gly Trp Lys Lys Gly Glu 
        275                 280                 285             


Gly Leu Gly Lys Asp Gly Gly Gly Met Lys Thr Pro Ile Gln Leu Gln 
    290                 295                 300                 


Leu Arg Arg Thr His Ala Gly Leu Gly Thr Gly Lys Pro Ser Ser Phe 
305                 310                 315                 320 


Glu Asp Val His Leu Leu Gln Asn Lys Asn Lys Lys Asn Trp Asp Lys 
                325                 330                 335     


Ala Arg Glu Arg Phe Thr Glu Asn Phe Pro Glu Thr Lys Pro Gln Lys 
            340                 345                 350         


Asp Asp Pro Gly Thr Met Pro Trp Val Lys Gly Thr Leu Glu 
        355                 360                 365     


<210>  8
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Ile Arg Ser Pro Val Leu Gln Ile Gly Ser Leu Phe Ile Ile 
1               5                   10                  15      


Thr Ala Val Asn Pro Ala Thr Ile Gly Arg Glu Lys Asp Met Glu His 
            20                  25                  30          


Thr Leu Arg Ile Pro Glu Val Gly Val Ser Lys Phe His Ala Glu Ile 
        35                  40                  45              


Tyr Phe Asp His Asp Leu Gln Ser Tyr Val Leu Val Asp Gln Gly Ser 
    50                  55                  60                  


Gln Asn Gly Thr Ile Val Asn Gly Lys Gln Ile Leu Gln Pro Lys Thr 
65                  70                  75                  80  


Lys Cys Asp Pro Tyr Val Leu Glu His Gly Asp Glu Val Lys Ile Gly 
                85                  90                  95      


Glu Thr Val Leu Ser Phe His Ile His Pro Gly Ser Asp Thr Cys Asp 
            100                 105                 110         


Gly Cys Glu Pro Gly Gln Val Arg Ala His Leu Arg Leu Asp Lys Lys 
        115                 120                 125             


Asp Glu Ser Phe Val Gly Pro Thr Leu Ser Lys Glu Glu Lys Glu Leu 
    130                 135                 140                 


Glu Arg Arg Lys Glu Leu Lys Lys Ile Arg Val Lys Tyr Gly Leu Gln 
145                 150                 155                 160 


Asn Thr Glu Tyr Glu Asp Glu Lys Thr Leu Lys Asn Pro Lys Tyr Lys 
                165                 170                 175     


Asp Arg Ala Gly Lys Arg Arg Glu Gln Val Gly Ser Glu Gly Thr Phe 
            180                 185                 190         


Gln Arg Asp Asp Ala Pro Ala Ser Val His Ser Glu Ile Thr Asp Ser 
        195                 200                 205             


Asn Lys Gly Arg Lys Met Leu Glu Lys Met Gly Trp Lys Lys Gly Glu 
    210                 215                 220                 


Gly Leu Gly Lys Asp Gly Gly Gly Met Lys Thr Pro Ile Gln Leu Gln 
225                 230                 235                 240 


Leu Arg Arg Thr His Ala Gly Leu Gly Thr Gly Lys Pro Ser Ser Phe 
                245                 250                 255     


Glu Asp Val His Leu Leu Gln Asn Lys Asn Lys Lys Asn Trp Asp Lys 
            260                 265                 270         


Ala Arg Glu Arg Phe Thr Glu Asn Phe Pro Glu Thr Lys Pro Gln Lys 
        275                 280                 285             


Asp Asp Pro Gly Thr Met Pro Trp Val Lys Gly Thr Leu Glu 
    290                 295                 300         


<210>  9
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Val Asp Gln Gly Ser Gln Asn Gly Thr Ile Val Asn Gly Lys Gln 
1               5                   10                  15      


Ile Leu Gln Pro Lys Thr Lys Cys Asp Pro Tyr Val Leu Glu His Gly 
            20                  25                  30          


Asp Glu Val Lys Ile Gly Glu Thr Val Leu Ser Phe His Ile His Pro 
        35                  40                  45              


Gly Ser Asp Thr Cys Asp Gly Cys Glu Pro Gly Gln Val Arg Ala His 
    50                  55                  60                  


Leu Arg Leu Asp Lys Lys Asp Glu Ser Phe Val Gly Pro Thr Leu Ser 
65                  70                  75                  80  


Lys Glu Glu Lys Glu Leu Glu Arg Arg Lys Glu Leu Lys Lys Ile Arg 
                85                  90                  95      


Val Lys Tyr Gly Leu Gln Asn Thr Glu Tyr Glu Asp Glu Lys Thr Leu 
            100                 105                 110         


Lys Asn Pro Lys Tyr Lys Asp Arg Ala Gly Lys Arg Arg Glu Gln Val 
        115                 120                 125             


Gly Ser Glu Gly Thr Phe Gln Arg Asp Asp Ala Pro Ala Ser Val His 
    130                 135                 140                 


Ser Glu Ile Thr Asp Ser Asn Lys Gly Arg Lys Met Leu Glu Lys Met 
145                 150                 155                 160 


Gly Trp Lys Lys Gly Glu Gly Leu Gly Lys Asp Gly Gly Gly Met Lys 
                165                 170                 175     


Thr Pro Ile Gln Leu Gln Leu Arg Arg Thr His Ala Gly Leu Gly Thr 
            180                 185                 190         


Gly Lys Pro Ser Ser Phe Glu Asp Val His Leu Leu Gln Asn Lys Asn 
        195                 200                 205             


Lys Lys Asn Trp Asp Lys Ala Arg Glu Arg Phe Thr Glu Asn Phe Pro 
    210                 215                 220                 


Glu Thr Lys Pro Gln Lys Asp Asp Pro Gly Thr Met Pro Trp Val Lys 
225                 230                 235                 240 


Gly Thr Leu Glu 
                


<210>  10
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Cys Asp Gly Cys Glu Pro Gly Gln Val Arg Ala His Leu Arg Leu 
1               5                   10                  15      


Asp Lys Lys Asp Glu Ser Phe Val Gly Pro Thr Leu Ser Lys Glu Glu 
            20                  25                  30          


Lys Glu Leu Glu Arg Arg Lys Glu Leu Lys Lys Ile Arg Val Lys Tyr 
        35                  40                  45              


Gly Leu Gln Asn Thr Glu Tyr Glu Asp Glu Lys Thr Leu Lys Asn Pro 
    50                  55                  60                  


Lys Tyr Lys Asp Arg Ala Gly Lys Arg Arg Glu Gln Val Gly Ser Glu 
65                  70                  75                  80  


Gly Thr Phe Gln Arg Asp Asp Ala Pro Ala Ser Val His Ser Glu Ile 
                85                  90                  95      


Thr Asp Ser Asn Lys Gly Arg Lys Met Leu Glu Lys Met Gly Trp Lys 
            100                 105                 110         


Lys Gly Glu Gly Leu Gly Lys Asp Gly Gly Gly Met Lys Thr Pro Ile 
        115                 120                 125             


Gln Leu Gln Leu Arg Arg Thr His Ala Gly Leu Gly Thr Gly Lys Pro 
    130                 135                 140                 


Ser Ser Phe Glu Asp Val His Leu Leu Gln Asn Lys Asn Lys Lys Asn 
145                 150                 155                 160 


Trp Asp Lys Ala Arg Glu Arg Phe Thr Glu Asn Phe Pro Glu Thr Lys 
                165                 170                 175     


Pro Gln Lys Asp Asp Pro Gly Thr Met Pro Trp Val Lys Gly Thr Leu 
            180                 185                 190         


Glu 
    


<210>  11
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Tyr Glu Asp Glu Lys Thr Leu Lys Asn Pro Lys Tyr Lys Asp 
1               5                   10                  15      


Arg Ala Gly Lys Arg Arg Glu Gln Val Gly Ser Glu Gly Thr Phe Gln 
            20                  25                  30          


Arg Asp Asp Ala Pro Ala Ser Val His Ser Glu Ile Thr Asp Ser Asn 
        35                  40                  45              


Lys Gly Arg Lys Met Leu Glu Lys Met Gly Trp Lys Lys Gly Glu Gly 
    50                  55                  60                  


Leu Gly Lys Asp Gly Gly Gly Met Lys Thr Pro Ile Gln Leu Gln Leu 
65                  70                  75                  80  


Arg Arg Thr His Ala Gly Leu Gly Thr Gly Lys Pro Ser Ser Phe Glu 
                85                  90                  95      


Asp Val His Leu Leu Gln Asn Lys Asn Lys Lys Asn Trp Asp Lys Ala 
            100                 105                 110         


Arg Glu Arg Phe Thr Glu Asn Phe Pro Glu Thr Lys Pro Gln Lys Asp 
        115                 120                 125             


Asp Pro Gly Thr Met Pro Trp Val Lys Gly Thr Leu Glu 
    130                 135                 140     


<210>  12
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Lys Tyr Lys Asp Arg Ala Gly Lys Arg Arg Glu Gln Val Gly 
1               5                   10                  15      


Ser Glu Gly Thr Phe Gln Arg Asp Asp Ala Pro Ala Ser Val His Ser 
            20                  25                  30          


Glu Ile Thr Asp Ser Asn Lys Gly Arg Lys Met Leu Glu Lys Met Gly 
        35                  40                  45              


Trp Lys Lys Gly Glu Gly Leu Gly Lys Asp Gly Gly Gly Met Lys Thr 
    50                  55                  60                  


Pro Ile Gln Leu Gln Leu Arg Arg Thr His Ala Gly Leu Gly Thr Gly 
65                  70                  75                  80  


Lys Pro Ser Ser Phe Glu Asp Val His Leu Leu Gln Asn Lys Asn Lys 
                85                  90                  95      


Lys Asn Trp Asp Lys Ala Arg Glu Arg Phe Thr Glu Asn Phe Pro Glu 
            100                 105                 110         


Thr Lys Pro Gln Lys Asp Asp Pro Gly Thr Met Pro Trp Val Lys Gly 
        115                 120                 125             


Thr Leu Glu 
    130     


<210>  13
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Glu Gln Val Gly Ser Glu Gly Thr Phe Gln Arg Asp Asp Ala 
1               5                   10                  15      


Pro Ala Ser Val His Ser Glu Ile Thr Asp Ser Asn Lys Gly Arg Lys 
            20                  25                  30          


Met Leu Glu Lys Met Gly Trp Lys Lys Gly Glu Gly Leu Gly Lys Asp 
        35                  40                  45              


Gly Gly Gly Met Lys Thr Pro Ile Gln Leu Gln Leu Arg Arg Thr His 
    50                  55                  60                  


Ala Gly Leu Gly Thr Gly Lys Pro Ser Ser Phe Glu Asp Val His Leu 
65                  70                  75                  80  


Leu Gln Asn Lys Asn Lys Lys Asn Trp Asp Lys Ala Arg Glu Arg Phe 
                85                  90                  95      


Thr Glu Asn Phe Pro Glu Thr Lys Pro Gln Lys Asp Asp Pro Gly Thr 
            100                 105                 110         


Met Pro Trp Val Lys Gly Thr Leu Glu 
        115                 120     


<210>  14
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gln Arg Asp Asp Ala Pro Ala Ser Val His Ser Glu Ile Thr Asp 
1               5                   10                  15      


Ser Asn Lys Gly Arg Lys Met Leu Glu Lys Met Gly Trp Lys Lys Gly 
            20                  25                  30          


Glu Gly Leu Gly Lys Asp Gly Gly Gly Met Lys Thr Pro Ile Gln Leu 
        35                  40                  45              


Gln Leu Arg Arg Thr His Ala Gly Leu Gly Thr Gly Lys Pro Ser Ser 
    50                  55                  60                  


Phe Glu Asp Val His Leu Leu Gln Asn Lys Asn Lys Lys Asn Trp Asp 
65                  70                  75                  80  


Lys Ala Arg Glu Arg Phe Thr Glu Asn Phe Pro Glu Thr Lys Pro Gln 
                85                  90                  95      


Lys Asp Asp Pro Gly Thr Met Pro Trp Val Lys Gly Thr Leu Glu 
            100                 105                 110     


<210>  15
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Ser Glu Ala Pro Ser Pro Pro Arg Ser Pro Pro Pro Pro Thr 
1               5                   10                  15      


Ser Pro Glu Pro Glu Leu Ala Gln Leu Arg Arg Lys Val Glu Lys Leu 
            20                  25                  30          


Glu Arg Glu Leu Arg Ser Cys Lys Arg Gln Val Arg Glu Ile Glu Lys 
        35                  40                  45              


Leu Leu His His Thr Glu Arg Leu Tyr Gln Asn Ala Glu Ser Asn Asn 
    50                  55                  60                  


Gln Glu Leu Arg Thr Gln Val Glu Glu Leu Ser Lys Ile Leu Gln Arg 
65                  70                  75                  80  


Gly Arg Asn Glu Asp Asn Lys Lys Ser Asp Val Glu Val Gln Thr Glu 
                85                  90                  95      


Asn His Ala Pro Trp Ser Ile Ser Asp Tyr Phe Tyr Gln Thr Tyr Tyr 
            100                 105                 110         


Asn Asp Val Ser Leu Pro Asn Lys Val Thr Glu Leu Ser Asp Gln Gln 
        115                 120                 125             


Asp Gln Ala Ile Glu Thr Ser Ile Leu Asn Ser Lys Asp His Leu Gln 
    130                 135                 140                 


Val Glu Asn Asp Ala Tyr Pro Gly Thr Asp Arg Thr Glu Asn Val Lys 
145                 150                 155                 160 


Tyr Arg Gln Val Asp His Phe Ala Ser Asn Ser Gln Glu Pro Ala Ser 
                165                 170                 175     


Ala Leu Ala Thr Glu Asp Thr Ser Leu Glu Gly Ser Ser Leu Ala Glu 
            180                 185                 190         


Ser Leu Arg Ala Ala Ala Glu Ala Ala Val Ser Gln Thr Gly Phe Ser 
        195                 200                 205             


Tyr Asp Glu Asn Thr Gly Leu Tyr Phe Asp His Ser Thr Gly Phe Tyr 
    210                 215                 220                 


Tyr Asp Ser Glu Asn Gln Leu Tyr Tyr Asp Pro Ser Thr Gly Ile Tyr 
225                 230                 235                 240 


Tyr Tyr Cys Asp Val Glu Ser Gly Arg Tyr Gln Phe His Ser Arg Val 
                245                 250                 255     


Asp Leu Gln Pro Tyr Pro Thr Ser Ser Thr Lys Gln Ser Lys Asp Lys 
            260                 265                 270         


Lys Leu Lys Lys Lys Arg Lys Asp Pro Asp Ser Ser Ala Thr Asn Glu 
        275                 280                 285             


Glu Lys Asp Leu Asn Ser Glu Asp Gln Lys Ala Phe Ser Val Glu His 
    290                 295                 300                 


Thr Ser Cys Asn Glu Glu Glu Asn Phe Ala Asn Met Lys Lys Lys Ala 
305                 310                 315                 320 


Lys Ile Gly Ile His His Lys Asn Ser Pro Pro Lys Val Thr Val Pro 
                325                 330                 335     


Thr Ser Gly Asn Thr Ile Glu Ser Pro Leu His Glu Asn Ile Ser Asn 
            340                 345                 350         


Ser Thr Ser Phe Lys Asp Glu Lys Ile Met Glu Thr Asp Ser Glu Pro 
        355                 360                 365             


Glu Glu Gly Glu Ile Thr Asp Ser Gln Thr Glu Asp Ser Tyr Asp Glu 
    370                 375                 380                 


Ala Ile Thr Ser Glu Gly Asn Val Thr Ala Glu Asp Ser Glu Asp Glu 
385                 390                 395                 400 


Asp Glu Asp Lys Ile Trp Pro Pro Cys Ile Arg Val Ile Val Ile Arg 
                405                 410                 415     


Ser Pro Val Leu Gln Ile Gly Ser Leu Phe Ile Ile Thr Ala Val Asn 
            420                 425                 430         


Pro Ala Thr Ile Gly Arg Glu Lys Asp Met Glu His Thr Leu Arg Ile 
        435                 440                 445             


Pro Glu Val Gly Val Ser Lys Phe His Ala Glu Ile Tyr Phe Asp His 
    450                 455                 460                 


Asp Leu Gln Ser Tyr Val Leu Val Asp Gln Gly Ser Gln Asn Gly Thr 
465                 470                 475                 480 


Ile Val Asn Gly Lys Gln Ile Leu Gln Pro Lys Thr Lys Cys Asp Pro 
                485                 490                 495     


Tyr Val Leu Glu His Gly Asp Glu Val Lys Ile Gly Glu Thr Val Leu 
            500                 505                 510         


Ser Phe His Ile His Pro Gly Ser Asp Thr Cys Asp Gly Cys Glu Pro 
        515                 520                 525             


Gly Gln Val Arg Ala His Leu Arg Leu Asp Lys Lys Asp Glu Ser Phe 
    530                 535                 540                 


Val Gly Pro Thr Leu Ser Lys Glu Glu Lys Glu Leu Glu Arg Arg Lys 
545                 550                 555                 560 


Glu Leu Lys Lys Ile Arg Val Lys Tyr Gly Leu Gln Asn Thr Glu Tyr 
                565                 570                 575     


Glu Asp Glu Lys Thr Leu Lys Asn Pro Lys Tyr Lys Asp Arg Ala Gly 
            580                 585                 590         


Lys Arg Arg Glu Gln Val Gly Ser Glu Gly Thr Phe Gln Arg Asp Asp 
        595                 600                 605             


Ala Pro Ala Ser Val His Ser Glu Ile Thr Asp Ser Asn Lys Gly Arg 
    610                 615                 620                 


Lys Met Leu Glu Lys Met Gly Trp Lys Lys Gly Glu Gly Leu Gly Lys 
625                 630                 635                 640 


Asp Gly Gly Gly Met Lys Thr Pro Ile Gln Leu Gln Leu Arg Arg Thr 
                645                 650                 655     


His Ala Gly Leu Gly Thr Gly Lys 
            660                 


<210>  16
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ser Glu Ala Pro Ser Pro Pro Arg Ser Pro Pro Pro Pro Thr 
1               5                   10                  15      


Ser Pro Glu Pro Glu Leu Ala Gln Leu Arg Arg Lys Val Glu Lys Leu 
            20                  25                  30          


Glu Arg Glu Leu Arg Ser Cys Lys Arg Gln Val Arg Glu Ile Glu Lys 
        35                  40                  45              


Leu Leu His His Thr Glu Arg Leu Tyr Gln Asn Ala Glu Ser Asn Asn 
    50                  55                  60                  


Gln Glu Leu Arg Thr Gln Val Glu Glu Leu Ser Lys Ile Leu Gln Arg 
65                  70                  75                  80  


Gly Arg Asn Glu Asp Asn Lys Lys Ser Asp Val Glu Val Gln Thr Glu 
                85                  90                  95      


Asn His Ala Pro Trp Ser Ile Ser Asp Tyr Phe Tyr Gln Thr Tyr Tyr 
            100                 105                 110         


Asn Asp Val Ser Leu Pro Asn Lys Val Thr Glu Leu Ser Asp Gln Gln 
        115                 120                 125             


Asp Gln Ala Ile Glu Thr Ser Ile Leu Asn Ser Lys Asp His Leu Gln 
    130                 135                 140                 


Val Glu Asn Asp Ala Tyr Pro Gly Thr Asp Arg Thr Glu Asn Val Lys 
145                 150                 155                 160 


Tyr Arg Gln Val Asp His Phe Ala Ser Asn Ser Gln Glu Pro Ala Ser 
                165                 170                 175     


Ala Leu Ala Thr Glu Asp Thr Ser Leu Glu Gly Ser Ser Leu Ala Glu 
            180                 185                 190         


Ser Leu Arg Ala Ala Ala Glu Ala Ala Val Ser Gln Thr Gly Phe Ser 
        195                 200                 205             


Tyr Asp Glu Asn Thr Gly Leu Tyr Phe Asp His Ser Thr Gly Phe Tyr 
    210                 215                 220                 


Tyr Asp Ser Glu Asn Gln Leu Tyr Tyr Asp Pro Ser Thr Gly Ile Tyr 
225                 230                 235                 240 


Tyr Tyr Cys Asp Val Glu Ser Gly Arg Tyr Gln Phe His Ser Arg Val 
                245                 250                 255     


Asp Leu Gln Pro Tyr Pro Thr Ser Ser Thr Lys Gln Ser Lys Asp Lys 
            260                 265                 270         


Lys Leu Lys Lys Lys Arg Lys Asp Pro Asp Ser Ser Ala Thr Asn Glu 
        275                 280                 285             


Glu Lys Asp Leu Asn Ser Glu Asp Gln Lys Ala Phe Ser Val Glu His 
    290                 295                 300                 


Thr Ser Cys Asn Glu Glu Glu Asn Phe Ala Asn Met Lys Lys Lys Ala 
305                 310                 315                 320 


Lys Ile Gly Ile His His Lys Asn Ser Pro Pro Lys Val Thr Val Pro 
                325                 330                 335     


Thr Ser Gly Asn Thr Ile Glu Ser Pro Leu His Glu Asn Ile Ser Asn 
            340                 345                 350         


Ser Thr Ser Phe Lys Asp Glu Lys Ile Met Glu Thr Asp Ser Glu Pro 
        355                 360                 365             


Glu Glu Gly Glu Ile Thr Asp Ser Gln Thr Glu Asp Ser Tyr Asp Glu 
    370                 375                 380                 


Ala Ile Thr Ser Glu Gly Asn Val Thr Ala Glu Asp Ser Glu Asp Glu 
385                 390                 395                 400 


Asp Glu Asp Lys Ile Trp Pro Pro Cys Ile Arg Val Ile Val Ile Arg 
                405                 410                 415     


Ser Pro Val Leu Gln Ile Gly Ser Leu Phe Ile Ile Thr Ala Val Asn 
            420                 425                 430         


Pro Ala Thr Ile Gly Arg Glu Lys Asp Met Glu His Thr Leu Arg Ile 
        435                 440                 445             


Pro Glu Val Gly Val Ser Lys Phe His Ala Glu Ile Tyr Phe Asp His 
    450                 455                 460                 


Asp Leu Gln Ser Tyr Val Leu Val Asp Gln Gly Ser Gln Asn Gly Thr 
465                 470                 475                 480 


Ile Val Asn Gly Lys Gln Ile Leu Gln Pro Lys Thr Lys Cys Asp Pro 
                485                 490                 495     


Tyr Val Leu Glu His Gly Asp Glu Val Lys Ile Gly Glu Thr Val Leu 
            500                 505                 510         


Ser Phe His Ile His Pro Gly Ser Asp Thr Cys Asp Gly Cys Glu Pro 
        515                 520                 525             


Gly Gln Val Arg Ala His Leu Arg Leu Asp Lys Lys Asp Glu Ser Phe 
    530                 535                 540                 


Val Gly Pro Thr Leu Ser Lys Glu Glu Lys Glu Leu Glu Arg Arg Lys 
545                 550                 555                 560 


Glu Leu Lys Lys Ile Arg Val Lys Tyr Gly Leu Gln Asn Thr Glu Tyr 
                565                 570                 575     


Glu Asp Glu Lys Thr Leu Lys Asn Pro Lys Tyr Lys Asp Arg Ala Gly 
            580                 585                 590         


Lys Arg Arg Glu Gln Val Gly Ser Glu Gly Thr Phe Gln Arg Asp Asp 
        595                 600                 605             


Ala Pro Ala Ser Val His 
    610                 


<210>  17
<211>  2145
<212>  RNA
<213>  Homo sapiens

<400>  17
auggccucgg aggcgccguc cccgccgcgg ucgccgccgc cgcccaccuc ccccgagccu       60

gagcuggccc agcuaaggcg gaagguggag aaguuggaac gugaacugcg gagcugcaag      120

cggcaggugc gggagaucga gaagcugcug caucacacag aacggcugua ccagaacgca      180

gaaagcaaca accaggagcu ccgcacgcag guggaagaac ucaguaaaau acuccaacgu      240

gggagaaaug aagauaauaa aaagucugau guagaaguac aaacagagaa ccaugcuccu      300

uggucaaucu cagauuauuu uuaucagacg uacuacaaug acguuagucu uccaaauaaa      360

gugacugaac ugucagauca acaagaucaa gcuaucgaaa cuucuauuuu gaauucuaaa      420

gaccauuuac aaguagaaaa ugaugcuuac ccugguaccg auagaacaga aaauguuaaa      480

uauagacaag uggaccauuu ugccucaaau ucacaggagc cagcaucugc auuagcaaca      540

gaagauaccu ccuuagaagg cucaucauua gcugaaaguu ugagagcugc agcagaagcg      600

gcuguaucac agacuggauu uaguuaugau gaaaauacug gacuguauuu ugaccacagc      660

acugguuucu auuaugauuc ugaaaaucaa cucuauuaug auccuuccac uggaauuuau      720

uacuauugug auguggaaag uggucguuau caguuucauu cucgaguaga uuugcaaccu      780

uauccgacuu cuagcacaaa acaaaguaaa gauaaaaaau ugaagaagaa aagaaaagau      840

ccagauucuu cugcaacaaa ugaggaaaag gauuugaacu cagaggauca aaaagccuuc      900

aguguugaac auacaagcug caaugaggaa gaaaauuucg caaauaugaa aaagaaggcc      960

aaaauaggca uucaucacaa aaauaguccc cccaaaguca cuguuccaac uaguggaaau     1020

acuauagagu cuccucuuca ugaaaacauc ucuaauucaa caucauuuaa agaugagaaa     1080

aucauggaga cugauaguga accagaggaa ggugaaauua cagacucuca gacugaggau     1140

aguuaugacg aagccauuac cagugaaggc aauguaacug cagaagauag ugaggaugaa     1200

gaugaagaca aaauuuggcc cccauguauu agaguaauug ucauuagauc accuguguug     1260

cagauaggau cacucuuuau cauuacugcu guaaacccug cuacaauugg aagagaaaag     1320

gauauggaac auacucuccg aaucccugaa guugguguca guaaguuuca ugcagaaauu     1380

uauuuugacc augacuuaca aaguuauguc cuuguggauc aaggcaguca aaauggcaca     1440

auuguuaaug gaaaacagau ucuucagccg aaaacuaaau gugacccuua cguacuugag     1500

cauggagaug aagucaaaau uggagaaacu gucuuauccu uucacauuca uccuggcagu     1560

gauaccugug auggcuguga accagggcag guuagagccc accuucgccu ugauaagaaa     1620

gaugaaucuu uuguuggucc aacacuaagu aaggaggaaa aagaguugga aagaagaaaa     1680

gaauuaaaga aaauacgagu aaaauauggu uuacagaaua cagaauacga agaugaaaag     1740

acauugaaga auccaaaaua uaaagauaga gcuggaaaac guagggagca gguuggaagu     1800

gaaggaacuu uccaaagaga ugaugcuccu gcaucuguuc auucugaaau uacugauagc     1860

aacaaagguc ggaagauguu ggagaagaug gguuggaaga aaggagaggg ccuggggaag     1920

gaugguggag gaaugaaaac gccgauccag cuucagcuuc ggcgaacaca ugcaggcuug     1980

gggacaggca aaccauccuc auuugaagau guucaccuuc uccaaaacaa gaacaaaaaa     2040

aacugggaca aagcacgaga gcgguuuacu gaaaacuucc cagaaacuaa gccucaaaaa     2100

gaugacccag ggaccaugcc uuggguaaaa gggacuuuag aguga                     2145


<210>  18
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18

Gln Arg Asp Asp Ala Pro Ala Ser Val His 
1               5                   10  


<210>  19
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19
cgagaagugu uugacuuuat t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20
uaaagucaaa cacuucucgt t                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  21
ugcccuucua caaccaggat t                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  22
uccugguugu agaagggcat t                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  23
uucuccgaac gugucacgut t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  24
acgugacacg uucggagaat t                                                 21


<210>  25
<211>  30
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  25
caaagagaug augcuccugc aucuguucau                                        30


