                         SEQUENCE LISTING

<110>  Yale University
       Bunick , Christopher
       Hinbest , Alexander
 
<120>  Selective Binding and Aggregation of Human Keratin in the Skin 
       Barrier Using Human Filaggrin Subdomains SD67 and SD150

<130>  47162-5263-00WO

<150>  62/742,512
<151>  2018-10-08

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  1

Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln Thr Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  2
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  2

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Lys Ser Gly Thr Arg His Thr Gln Asn Ser Ser Ser Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  3
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  3

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Ser Arg His Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Pro His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  4
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  4

Ser Asp Asp Ser Glu Arg Leu Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ser Arg Glu Gln Ser Arg Asp Gly Ser Arg His Pro Gly Phe 
            20                  25                  30          


His Gln Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr His His Thr Glu Ser Ser Ser His Gly Gln Ala Val 
    50                  55                  60                  


Ser Ser His 
65          


<210>  5
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  5

Ser Glu Asp Ser Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His Tyr 
1               5                   10                  15      


Gly Ser Ala Arg Glu Gln Ser Arg His Gly Ser Arg Asn Pro Arg Ser 
            20                  25                  30          


His Gln Glu Asp Arg Ala Ser His Gly His Ser Ala Glu Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser Gln 
65          


<210>  6
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  6

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His Leu 
1               5                   10                  15      


Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro Gly Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Thr Glu Ser Ser Ser Arg Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  7
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  7

Ser Glu Asp Ser Glu Arg Arg Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Glu Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr His His Ala Glu Asn Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  8
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  8

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Leu Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His Gln Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Thr Gln Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  9
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  9

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Leu Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His Gln Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Thr Gln Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  10
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  10

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg 
1               5                   10                  15      


Gly Ser Val Gln Glu Gln Ser Arg His Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Arg Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  11
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  11

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His Pro Thr Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Glu Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr His His Ala Glu Asn Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  12
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  12

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  13
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67-derived peptide

<400>  13

Pro Glu Asp Ser Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ser Arg Glu Gln Ser Arg Asp Gly Ser Arg His Pro Gly Ser 
            20                  25                  30          


Ser His Arg Asp Thr Ala Ser His 
        35                  40  


<210>  14
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  14

Ser Glu Asn Ser Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly 
1               5                   10                  15      


Leu Arg Gln Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Ser Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Pro Asp Ser Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asn Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser His Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser 
145                 


<210>  15
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  15

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala Gly 
1               5                   10                  15      


His His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly Glu 
            20                  25                  30          


Arg Ser Arg Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Lys 
        35                  40                  45              


Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Gly Val Arg 
    50                  55                  60                  


Gln Gly Ser His His Glu Gln Ala Arg Asp Asn Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Arg Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Arg 
145                 150 


<210>  16
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  16

Ser Glu Glu Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Asp Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Trp Ser Gly Gly 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Ile Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Thr Arg Thr Ser Thr Gly Arg Arg 
    50                  55                  60                  


Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Ala His Pro Gly Ser Arg Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser His Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Lys Asp Lys Gln Ser Gly 
145                 150 


<210>  17
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  17

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Lys Glu Ser Ala Arg Gly Gln Ser Gly Glu 
            20                  25                  30          


Ser Ser Gly Arg Ser Arg Ser Phe Leu Tyr Gln Val Ser Ser His Glu 
        35                  40                  45              


Gln Ser Glu Ser Thr His Gly Gln Thr Ala Pro Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser Arg His Glu Gln Ala Arg Asn Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Tyr His His Ser His Thr Thr Pro Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser His Gly Gln Ser Gly Pro Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Gly 
145                 150 


<210>  18
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  18

Ser Glu Glu Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Gln Ser Gly Glu 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Thr Gly Pro Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Arg Ser Arg His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His Tyr Glu Gln Ser Val Asp Ser Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Glu Arg Ser Asp 
        115                 120                 125             


Val Ser Arg Gly Gln Ser Gly Ser Arg Ser Val Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Glu Lys Gln Ser Gly 
145                 150 


<210>  19
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  19

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala Gln Gly Lys Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Lys Glu Ser Ala Arg Gly Gln Ser Gly Glu 
            20                  25                  30          


Ser Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Thr His Gly Gln Ser Ala Pro Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser His Tyr Asp Gln Ala Gln Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Pro Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His Gln Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Lys Thr Tyr 
    130                 135                 140                 


Asp Lys Glu Gln Ser Gly 
145                 150 


<210>  20
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  20

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser Ala Gly 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser His His Lys Gln Ala Arg Asp Ser Ser Arg His Ser Thr 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile His Gly His Pro Gly Ser Ser Ser 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His Tyr Glu Gln Leu Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser His Gly His Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Asp Glu Gln Ser Gly 
145                 150 


<210>  21
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  21

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Ser His Gln Gln Ser His Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu 
            20                  25                  30          


Thr Ser Gly His Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Arg Gly Arg 
    50                  55                  60                  


Gln Gly Ser Arg His Glu Gln Ala Gln Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Tyr His His Glu His Ser Val Asp Ser Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Gly 
145                 150 


<210>  22
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  22

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Ser His Gln Gln Ser His Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu 
            20                  25                  30          


Thr Ser Gly His Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Arg Gly Arg 
    50                  55                  60                  


Gln Gly Ser Arg His Glu Gln Ala Gln Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Tyr Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Tyr His His Glu His Ser Val Asp Ser Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Gly 
145                 150 


<210>  23
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  23

Ser Glu Glu Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly Gly 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Thr Arg Thr Ser Thr Gly Arg Arg 
    50                  55                  60                  


Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Arg Gly Arg Gln Gly Ser His Tyr Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Asp Glu Gln Ser Gly 
145                 150 


<210>  24
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  24

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser Ala Gly 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Ala Gly Pro Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser Arg His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Arg Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser His Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Glu Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Gly 
145                 150 


<210>  25
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150-derived peptide

<400>  25

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Thr Gly Pro Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Gly 
145                 150 


<210>  26
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  26

Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Gly His Gln 
1               5                   10                  15      


Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr Gly Arg Gly Gln Ala 
            20                  25                  30          


Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly Ser Ser Gly Ser Gln 
        35                  40                  45              


Ala Ser Asp Ser Glu Gly His 
    50                  55  


<210>  27
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  27

Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg His Gly Ser Arg His Gln 
1               5                   10                  15      


Leu Gln Ser Ala Asp Ser Ser Arg His Ser Gly Thr Gly His Gly Gln 
            20                  25                  30          


Ala Ser Ser Ala Val Arg Asp Ser Gly His Arg Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Ala Thr Asp Ser Glu Gly His 
    50                  55      


<210>  28
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  28

Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg His Gln 
1               5                   10                  15      


Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ile Pro Arg Arg Gln Ala 
            20                  25                  30          


Ser Ser Ala Val Arg Asp Ser Gly His Trp Gly Ser Ser Gly Ser Gln 
        35                  40                  45              


Ala Ser Asp Ser Glu Gly His 
    50                  55  


<210>  29
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  29

Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg His Gln 
1               5                   10                  15      


Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ile Gly His Arg Gln Ala 
            20                  25                  30          


Ser Ser Ala Val Arg Asp Ser Gly His Arg Gly Ser Ser Gly Ser Gln 
        35                  40                  45              


Val Thr Asn Ser Glu Gly His 
    50                  55  


<210>  30
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  30

Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg His Gln 
1               5                   10                  15      


Gln Ser Ala Asp Ser Ser Thr Asp Ser Gly Thr Gly Arg Arg Gln Asp 
            20                  25                  30          


Ser Ser Val Val Gly Asp Ser Gly Asn Arg Gly Ser Ser Gly Ser Gln 
        35                  40                  45              


Ala Ser Asp Ser Glu Gly His 
    50                  55  


<210>  31
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  31

Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg His Gly Ser His His Gln 
1               5                   10                  15      


Leu Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ile Gly His Gly Gln 
            20                  25                  30          


Ala Ser Ser Ala Val Arg Asp Ser Gly His Arg Gly Tyr Ser Gly Ser 
        35                  40                  45              


Gln Ala Ser Asp Ser Glu Gly His 
    50                  55      


<210>  32
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  32

Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg His Gly Ser His His Gln 
1               5                   10                  15      


Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ile Gly His Gly Gln Ala 
            20                  25                  30          


Ser Ser Ala Val Arg Asp Ser Gly His Arg Gly Ser Ser Gly Ser Gln 
        35                  40                  45              


Ala Ser Asp Ser Glu Gly His 
    50                  55  


<210>  33
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  33

Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg His Gly Ser His His Gln 
1               5                   10                  15      


Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ile Gly His Gly Gln Ala 
            20                  25                  30          


Ser Ser Ala Val Arg Asp Ser Gly His Arg Gly Tyr Ser Gly Ser Gln 
        35                  40                  45              


Ala Ser Asp Asn Glu Gly His 
    50                  55  


<210>  34
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  34

Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg His Gly Ser His His Gln 
1               5                   10                  15      


Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ile Gly His Gly Gln Ala 
            20                  25                  30          


Ser Ser Ala Val Arg Asp Ser Gly His Arg Gly Tyr Ser Gly Ser Gln 
        35                  40                  45              


Ala Ser Asp Asn Glu Gly His 
    50                  55  


<210>  35
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  35

Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg His Gln 
1               5                   10                  15      


Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ile Pro Arg Gly Gln Ala 
            20                  25                  30          


Ser Ser Ala Val Arg Asp Ser Arg His Trp Gly Ser Ser Gly Ser Gln 
        35                  40                  45              


Ala Ser Asp Ser Glu Gly His 
    50                  55  


<210>  36
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD55

<400>  36

Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg His Gly Ser His His Gln 
1               5                   10                  15      


Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ile Gly His Gly Gln Ala 
            20                  25                  30          


Ser Ser Ala Val Arg Asp Ser Gly His Arg Gly Ser Ser Gly Ser Gln 
        35                  40                  45              


Ala Ser Asp Ser Glu Gly His 
    50                  55  


<210>  37
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated SD52

<400>  37

Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn Arg 
1               5                   10                  15      


Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg Thr 
            20                  25                  30          


Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu Gly 
        35                  40                  45              


His 
    


<210>  38
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  38

Asp Gly Thr Arg His Ser Gly Ser Arg His His Glu Ala Ser Ser Gln 
1               5                   10                  15      


Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser Ser Gly 
            20                  25                  30          


Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp Ser Asp 
        35                  40                  45              


Ser Gln Gly His 
    50          


<210>  39
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  39

Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser Ser His 
1               5                   10                  15      


Ala Asp Ile Ser Arg His Ser Gln Ala Gly Gln Gly Gln Ser Glu Gly 
            20                  25                  30          


Ser Arg Thr Ser Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Ser Asp 
        35                  40                  45              


Ser Glu Gly His 
    50          


<210>  40
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  40

Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ala Ser Trp 
1               5                   10                  15      


Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Glu Gln Ser Ser Gly 
            20                  25                  30          


Ser Arg Thr Ser Arg His Gln Gly Ser Ser Val Ser Gln Asp Ser Asp 
        35                  40                  45              


Ser Glu Arg His 
    50          


<210>  41
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  41

Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Pro Ser Thr Arg 
1               5                   10                  15      


Ala Gly Ser Ser Arg His Ser Gln Val Gly Gln Gly Glu Ser Ala Gly 
            20                  25                  30          


Ser Lys Thr Ser Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Arg Asp 
        35                  40                  45              


Ser Glu Gly His 
    50          


<210>  42
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  42

Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser Ser Arg 
1               5                   10                  15      


Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser Ser Gly 
            20                  25                  30          


Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp Ser Asp 
        35                  40                  45              


Ser Gln Gly His 
    50          


<210>  43
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  43

Asp Gly Ser Arg His Ser Gly Ser His His His Glu Ala Ser Ser Trp 
1               5                   10                  15      


Ala Asp Ser Ser Arg His Ser Leu Val Gly Gln Gly Gln Ser Ser Gly 
            20                  25                  30          


Pro Arg Thr Ser Arg Pro Arg Gly Ser Ser Val Ser Gln Asp Ser Asp 
        35                  40                  45              


Ser Glu Gly His 
    50          


<210>  44
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  44

Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser Ser Arg 
1               5                   10                  15      


Ala Asp Ser Ser Gly His Ser Gln Val Gly Gln Gly Gln Ser Glu Gly 
            20                  25                  30          


Pro Arg Thr Ser Arg Asn Trp Gly Ser Ser Phe Ser Gln Asp Ser Asp 
        35                  40                  45              


Ser Gln Gly His 
    50          


<210>  45
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  45

Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser Thr His 
1               5                   10                  15      


Ala Asp Ile Ser Arg His Ser Gln Ala Val Gln Gly Gln Ser Glu Gly 
            20                  25                  30          


Ser Arg Arg Ser Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Ser Asp 
        35                  40                  45              


Ser Glu Gly His 
    50          


<210>  46
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  46

Asp Ser Ser Arg His Ser Val Ser Arg His His Glu Ala Ser Thr His 
1               5                   10                  15      


Ala Asp Ile Ser Arg His Ser Gln Ala Val Gln Gly Gln Ser Glu Gly 
            20                  25                  30          


Ser Arg Arg Ser Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Ser Asp 
        35                  40                  45              


Ser Glu Gly His 
    50          


<210>  47
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  47

Asp Gly Ser Arg His Ser Trp Ser His His His Glu Ala Ser Thr Gln 
1               5                   10                  15      


Ala Asp Ser Ser Arg His Ser Gln Ser Gly Gln Gly Gln Ser Ala Gly 
            20                  25                  30          


Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp Ser Asp 
        35                  40                  45              


Ser Gln Gly His 
    50          


<210>  48
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD52

<400>  48

Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser Thr Gln 
1               5                   10                  15      


Ala Asp Ser Ser Arg His Ser Gln Ser Gly Gln Gly Glu Ser Ala Gly 
            20                  25                  30          


Ser Arg Arg Ser Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Ser Asp 
        35                  40                  45              


Ser Glu Ala Tyr 
    50          


<210>  49
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  49

Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln Thr Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  50
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  50

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Lys Ser Gly Thr Arg His Thr Gln Asn Ser Ser Ser Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  51
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  51

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Ser Arg His Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Pro His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  52
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  52

Ser Asp Asp Ser Glu Arg Leu Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ser Arg Glu Gln Ser Arg Asp Gly Ser Arg His Pro Gly Phe 
            20                  25                  30          


His Gln Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr His His Thr Glu Ser Ser Ser His Gly Gln Ala Val 
    50                  55                  60                  


Ser Ser His 
65          


<210>  53
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  53

Ser Glu Asp Ser Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His Tyr 
1               5                   10                  15      


Gly Ser Ala Arg Glu Gln Ser Arg His Gly Ser Arg Asn Pro Arg Ser 
            20                  25                  30          


His Gln Glu Asp Arg Ala Ser His Gly His Ser Ala Glu Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser Gln 
65          


<210>  54
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  54

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His Leu 
1               5                   10                  15      


Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro Gly Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Thr Glu Ser Ser Ser Arg Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  55
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  55

Ser Glu Asp Ser Glu Arg Arg Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Glu Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr His His Ala Glu Asn Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  56
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  56

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Leu Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His Gln Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Thr Gln Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  57
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  57

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Leu Arg Asp Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His Gln Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Thr Gln Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  58
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  58

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg 
1               5                   10                  15      


Gly Ser Val Gln Glu Gln Ser Arg His Gly Ser Arg His Pro Arg Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Arg Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  59
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  59

Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg 
1               5                   10                  15      


Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His Pro Thr Ser 
            20                  25                  30          


His His Glu Asp Arg Ala Gly His Gly His Ser Ala Glu Ser Ser Arg 
        35                  40                  45              


Gln Ser Gly Thr His His Ala Glu Asn Ser Ser Gly Gly Gln Ala Ala 
    50                  55                  60                  


Ser Ser His 
65          


<210>  60
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD67

<400>  60

Pro Glu Asp Ser Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His His 
1               5                   10                  15      


Gly Ser Ser Arg Glu Gln Ser Arg Asp Gly Ser Arg His Pro Gly Ser 
            20                  25                  30          


Ser His Arg Asp Thr Ala Ser His Val Gln Ser Ser Pro Val Gln Ser 
        35                  40                  45              


Asp Ser Ser Thr Ala Lys Glu His Gly His Phe Ser Ser Leu Ser Gln 
    50                  55                  60                  


Asp Ser Ala 
65          


<210>  61
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  61

Ser Glu Asn Ser Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly 
1               5                   10                  15      


Leu Arg Gln Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Ser Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Pro Asp Ser Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asn Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser His Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser 
145                 


<210>  62
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  62

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala Gly 
1               5                   10                  15      


His His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly Glu 
            20                  25                  30          


Arg Ser Arg Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Lys 
        35                  40                  45              


Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Gly Val Arg 
    50                  55                  60                  


Gln Gly Ser His His Glu Gln Ala Arg Asp Asn Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Arg Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Arg 
145                 150 


<210>  63
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  63

Ser Glu Glu Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Asp Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Trp Ser Gly Gly 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Ile Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Thr Arg Thr Ser Thr Gly Arg Arg 
    50                  55                  60                  


Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Ala His Pro Gly Ser Arg Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser His Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Lys Asp Lys Gln Ser Gly 
145                 150 


<210>  64
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  64

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Lys Glu Ser Ala Arg Gly Gln Ser Gly Glu 
            20                  25                  30          


Ser Ser Gly Arg Ser Arg Ser Phe Leu Tyr Gln Val Ser Ser His Glu 
        35                  40                  45              


Gln Ser Glu Ser Thr His Gly Gln Thr Ala Pro Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser Arg His Glu Gln Ala Arg Asn Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Tyr His His Ser His Thr Thr Pro Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser His Gly Gln Ser Gly Pro Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Gly 
145                 150 


<210>  65
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  65

Ser Glu Glu Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Gln Ser Gly Glu 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Thr Gly Pro Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Arg Ser Arg His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His Tyr Glu Gln Ser Val Asp Ser Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Glu Arg Ser Asp 
        115                 120                 125             


Val Ser Arg Gly Gln Ser Gly Ser Arg Ser Val Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Glu Lys Gln Ser Gly 
145                 150 


<210>  66
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  66

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala Gln Gly Lys Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Lys Glu Ser Ala Arg Gly Gln Ser Gly Glu 
            20                  25                  30          


Ser Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Thr His Gly Gln Ser Ala Pro Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser His Tyr Asp Gln Ala Gln Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Pro Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His Gln Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Lys Thr Tyr 
    130                 135                 140                 


Asp Lys Glu Gln Ser Gly 
145                 150 


<210>  67
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  67

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser Ala Gly 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser His His Lys Gln Ala Arg Asp Ser Ser Arg His Ser Thr 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile His Gly His Pro Gly Ser Ser Ser 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser His Tyr Glu Gln Leu Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser His Gly His Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Asp Glu Gln Ser Gly 
145                 150 


<210>  68
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  68

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Ser His Gln Gln Ser His Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu 
            20                  25                  30          


Thr Ser Gly His Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Arg Gly Arg 
    50                  55                  60                  


Gln Gly Ser Arg His Glu Gln Ala Gln Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Tyr His His Glu His Ser Val Asp Ser Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Gly 
145                 150 


<210>  69
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  69

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Ser His Gln Gln Ser His Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu 
            20                  25                  30          


Thr Ser Gly His Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Arg Gly Arg 
    50                  55                  60                  


Gln Gly Ser Arg His Glu Gln Ala Gln Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Tyr Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Tyr His His Glu His Ser Val Asp Ser Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Gly 
145                 150 


<210>  70
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  70

Ser Glu Glu Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly Gly 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Thr Arg Thr Ser Thr Gly Arg Arg 
    50                  55                  60                  


Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
                85                  90                  95      


Arg Gly Arg Gln Gly Ser His Tyr Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
    130                 135                 140                 


Asn Asp Glu Gln Ser Gly 
145                 150 


<210>  71
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SD150

<400>  71

Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
1               5                   10                  15      


Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser Ala Gly 
            20                  25                  30          


Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
        35                  40                  45              


Gln Ser Glu Ser Ala His Gly Arg Ala Gly Pro Ser Thr Gly Gly Arg 
    50                  55                  60                  


Gln Gly Ser Arg His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
65                  70                  75                  80  


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Arg Arg 
                85                  90                  95      


Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser Val Asp Arg Ser Gly 
            100                 105                 110         


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
        115                 120                 125             


Ala Ser His Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Glu Thr Arg 
    130                 135                 140                 


Asn Glu Glu Gln Ser Gly 
145                 150 


<210>  72
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal motif of SD55 and SD52

<400>  72

Ser Asp Ser Glu Gly His 
1               5       


