                         SEQUENCE LISTING

<110>  Allen Institute
       Seattle Children's Research Institute
 
<120>  ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE 
       EXPRESSION IN INTERNEURONS

<130>  A166-0006PCT/18-30PCT/SCRI.216

<150>  US 62/742,835
<151>  2018-10-08

<150>  US 62/749,012
<151>  2018-10-22

<150>  US 62/810,281
<151>  2019-02-25

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  528
<212>  DNA
<213>  Homo sapiens

<400>  1
tatgcactca cagtggtttg gcatgcatct ggtgaatttt ttttaacgaa aaattagtgt       60

tggtttcgat gtatggtagc attctcccta acgtaatttg aataattcag caaagcccca      120

ctaccagctg tacttctgca gcctcttcca ttcttttcag cattataatt ttggttaatt      180

ttcaatttta ggtcctacgt ctctgcaatt tgtgtatgaa taacagaata atttccctct      240

tttgtttcgc ctttcctgtt cctgaatcta aataaagatg gctttttagt attaaaagtg      300

gaagaaaatt acaggtaatt atctttgacg gtaaaaacgc tgtaatcagc gggctacatg      360

aaaaattact ctaattatgg ctgcatttaa gagaatggaa aaaaaccttc ttgtggataa      420

aaaccttaaa ttgtccccaa tgtctgcttc aaattggatg gcactgcagc tggaggcttt      480

gttcagaatt gatcctgggg agctacgaac ccaaagtttc acagtagg                   528


<210>  2
<211>  131
<212>  DNA
<213>  Homo sapiens

<400>  2
ctaaataaag atggcttttt agtattaaaa gtggaagaaa attacaggta attatctttg       60

acggtaaaaa cgctgtaatc agcgggctac atgaaaaatt actctaatta tggctgcatt      120

taagagaatg g                                                           131


<210>  3
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Triply concatamerized core of Homo spaiens I56i Core

<400>  3
ctaaataaag atggcttttt agtattaaaa gtggaagaaa attacaggta attatctttg       60

acggtaaaaa cgctgtaatc agcgggctac atgaaaaatt actctaatta tggctgcatt      120

taagagaatg gctaaataaa gatggctttt tagtattaaa agtggaagaa aattacaggt      180

aattatcttt gacggtaaaa acgctgtaat cagcgggcta catgaaaaat tactctaatt      240

atggctgcat ttaagagaat ggctaaataa agatggcttt ttagtattaa aagtggaaga      300

aaattacagg taattatctt tgacggtaaa aacgctgtaa tcagcgggct acatgaaaaa      360

ttactctaat tatggctgca tttaagagaa tgg                                   393


<210>  4
<211>  527
<212>  DNA
<213>  Mus musculus

<400>  4
tatacactca cagtggtttg gcatatattt ggtgaaattt tttaaggaaa aattagtgtt       60

ggtttcgata tatggtagct ttttctctaa cataatttga ataattcagc aaagccctac      120

taccagctgt acttctgcag cctcttccat tctttccagc attataattt tggttaattt      180

tcaattttag gtcctacgtc tctgcaattt gtgtatgaat aacagaataa tttccctctt      240

ttgtttcgcc tttcctgttc ctgaatctaa ataaagatgg ctttttagta ttaaaagtgg      300

aagaaaatta caggtaatta tctttgacgg taaaaacgct gtaatcagcg ggctacatga      360

aaaattactc taattatggc tgcatttaag agaatggaaa aaaaccttct tgtggataaa      420

aaccttaaat tgtccccaat gtctgcttca aattggatgg cactgcagct ggaggctttg      480

ttcagaattg atcctgggga gctacgaacc caaagtttca cagtagg                    527


<210>  5
<211>  281
<212>  DNA
<213>  Danio rerio

<400>  5
acattgtaat tttagataat atcccaagcg ttcactctcc tcggcaattt gtacatgaat       60

aaccgaataa tttcatcttt tgtttcgtct ttgccacttc aaatccaaat aaagatgcct      120

tttagtatta aaagtggtag aaaattacag gtaattatct ttgacggtaa aaacgctgta      180

atcagcgggc tacatcaaaa attaccctaa ttatgtctgc atttatgaga atggaaaaaa      240

accctctctt ggataaaacc cataaattgt cccaaatatc t                          281


<210>  6
<211>  130
<212>  DNA
<213>  Danio rerio

<400>  6
ccaaataaag atgcctttta gtattaaaag tggtagaaaa ttacaggtaa ttatctttga       60

cggtaaaaac gctgtaatca gcgggctaca tcaaaaatta ccctaattat gtctgcattt      120

atgagaatgg                                                             130


<210>  7
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Triply concatamerized core of I56i enhancer from Danio rerio

<400>  7
ccaaataaag atgcctttta gtattaaaag tggtagaaaa ttacaggtaa ttatctttga       60

cggtaaaaac gctgtaatca gcgggctaca tcaaaaatta ccctaattat gtctgcattt      120

atgagaatgg ccaaataaag atgcctttta gtattaaaag tggtagaaaa ttacaggtaa      180

ttatctttga cggtaaaaac gctgtaatca gcgggctaca tcaaaaatta ccctaattat      240

gtctgcattt atgagaatgg ccaaataaag atgcctttta gtattaaaag tggtagaaaa      300

ttacaggtaa ttatctttga cggtaaaaac gctgtaatca gcgggctaca tcaaaaatta      360

ccctaattat gtctgcattt atgagaatgg                                       390


<210>  8
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-Globin Minimal Promoter

<400>  8
gggctgggca taaaagtcag ggcagagcca tctattgctt acatttgctt ctg              53


<210>  9
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  minCMV Promoter

<400>  9
gaggtaggcg tgtacggtgg gaggcctata taagcagagc tcgtttagtg aaccgtcaga       60

tcgcctgg                                                                68


<210>  10
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated minCMV Promoter

<400>  10
gaggtaggcg tgtacggtgg gaggcctata taagcagagc tggtttagtg aaccgtcaga       60

tcgcctgg                                                                68


<210>  11
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  minRho Promoter

<400>  11
gattcagccg ggagcttagg gaggggaggt cacttcataa gggcctgggg ggggagttgg       60

agccacgagt cgtccagccg gagccccgtg tggctgagct ccggcctcag aagcatcccc      120


<210>  12
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsp68 minimal Promoter

<400>  12
caggaacatc caaactgagc agccggggtc ccccccaccc cccaccccgc cccacgcggc       60

aactttgagc ctgtgctggg acagagcctc tagttcctaa attagtccat gaggtcagag      120

gcagcactgc cattgtaacg cgattggaga ggatcacgtc accggacacg cccccaggca      180

tctccctggg tctcctaaac ttggcgggga gaagttttag cccttaagtt ttagccttta      240

acccccatat tcagaactgt gcgagttggc gaaaccccac aaatcacaac aaactgtaca      300

caacaccgag ctagaggtga tctttcttgt ccattccaca caggccttag taatgcgtcg      360

ccatagcaac agtgtcacta gtagcaccag cacttcccca caccctcccc ctcaggaatc      420

cgtactctcc agtgaacccc agaaacctct ggagagttct ggacaagggc ggaacccaca      480

actccgatta ctcaagggag gcggggaagc tccaccagac gcgaaactgc tggaagattc      540

ctggccccaa ggcctcctcc ggctcgctga ttggcccagc ggagagtggg cggggccggt      600

gaagactcct taaaggcgca gggcggcgag caggtcacca gacgctgaca gctactcaga      660

accaaatctg gttccatcca gagacaagcg aagacaagag aagcagagcg agcggcgcgt      720

tcccgatcct cggccaggac cagccttccc cagagcatcc ctgccgcgga gcgcaacctt      780

cccaggagca tccctgccgc ggagcgcaac tttccccgga gcatccacgc cgcggagcgc      840

agccttccag aagcagagcg cggcgcc                                          867


<210>  13
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYFP2

<400>  13
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagct gatctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgggcta cggcgtgcag tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac      480

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagct accagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210>  14
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enhanced green fluorescent protein (EGFP)

<400>  14
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210>  15
<211>  1299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized Flp recombinase

<400>  15
atggctccta agaagaagag gaaggtgatg agccagttcg acatcctgtg caagaccccc       60

cccaaggtgc tggtgcggca gttcgtggag agattcgaga ggcccagcgg cgagaagatc      120

gccagctgtg ccgccgagct gacctacctg tgctggatga tcacccacaa cggcaccgcc      180

atcaagaggg ccaccttcat gagctacaac accatcatca gcaacagcct gagcttcgac      240

atcgtgaaca agagcctgca gttcaagtac aagacccaga aggccaccat cctggaggcc      300

agcctgaaga agctgatccc cgcctgggag ttcaccatca tcccttacaa cggccagaag      360

caccagagcg acatcaccga catcgtgtcc agcctgcagc tgcagttcga gagcagcgag      420

gaggccgaca agggcaacag ccacagcaag aagatgctga aggccctgct gtccgagggc      480

gagagcatct gggagatcac cgagaagatc ctgaacagct tcgagtacac cagcaggttc      540

accaagacca agaccctgta ccagttcctg ttcctggcca cattcatcaa ctgcggcagg      600

ttcagcgaca tcaagaacgt ggaccccaag agcttcaagc tggtgcagaa caagtacctg      660

ggcgtgatca ttcagtgcct ggtgaccgag accaagacaa gcgtgtccag gcacatctac      720

tttttcagcg ccagaggcag gatcgacccc ctggtgtacc tggacgagtt cctgaggaac      780

agcgagcccg tgctgaagag agtgaacagg accggcaaca gcagcagcaa caagcaggag      840

taccagctgc tgaaggacaa cctggtgcgc agctacaaca aggccctgaa gaagaacgcc      900

ccctacccca tcttcgctat caagaacggc cctaagagcc acatcggcag gcacctgatg      960

accagctttc tgagcatgaa gggcctgacc gagctgacaa acgtggtggg caactggagc     1020

gacaagaggg cctccgccgt ggccaggacc acctacaccc accagatcac cgccatcccc     1080

gaccactact tcgccctggt gtccaggtac tacgcctacg accccatcag caaggagatg     1140

atcgccctga aggacgagac caaccccatc gaggagtggc agcacatcga gcagctgaag     1200

ggcagcgccg agggcagcat cagatacccc gcctggaacg gcatcatcag ccaggaggtg     1260

ctggactacc tgagcagcta catcaacagg cggatctga                            1299


<210>  16
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Improved Cre recombinase (iCre)

<400>  16
atggtgccca agaagaagag gaaagtctcc aacctgctga ctgtgcacca aaacctgcct       60

gccctccctg tggatgccac ctctgatgaa gtcaggaaga acctgatgga catgttcagg      120

gacaggcagg ccttctctga acacacctgg aagatgctcc tgtctgtgtg cagatcctgg      180

gctgcctggt gcaagctgaa caacaggaaa tggttccctg ctgaacctga ggatgtgagg      240

gactacctcc tgtacctgca agccagaggc ctggctgtga agaccatcca acagcacctg      300

ggccagctca acatgctgca caggagatct ggcctgcctc gcccttctga ctccaatgct      360

gtgtccctgg tgatgaggag aatcagaaag gagaatgtgg atgctgggga gagagccaag      420

caggccctgg cctttgaacg cactgacttt gaccaagtca gatccctgat ggagaactct      480

gacagatgcc aggacatcag gaacctggcc ttcctgggca ttgcctacaa caccctgctg      540

cgcattgccg aaattgccag aatcagagtg aaggacatct cccgcaccga tggtgggaga      600

atgctgatcc acattggcag gaccaagacc ctggtgtcca cagctggtgt ggagaaggcc      660

ctgtccctgg gggttaccaa gctggtggag agatggatct ctgtgtctgg tgtggctgat      720

gaccccaaca actacctgtt ctgccgggtc agaaagaatg gtgtggctgc cccttctgcc      780

acctcccaac tgtccacccg ggccctggaa gggatctttg aggccaccca ccgcctgatc      840

tatggtgcca aggatgactc tgggcagaga tacctggcct ggtctggcca ctctgccaga      900

gtgggtgctg ccagggacat ggccagggct ggtgtgtcca tccctgaaat catgcaggct      960

ggtggctgga ccaatgtgaa cattgtgatg aactacatca gaaacctgga ctctgagact     1020

ggggccatgg tgaggctgct cgaggatggg gactaa                               1056


<210>  17
<211>  825
<212>  DNA
<213>  Magnetococcus marinus

<400>  17
atgtcacgca aaataagaga tttaatcgaa tccaaacgct ttcaaaacgt catcaccgcc       60

attattgtgc tcaatggcgc tgtgctgggt ctgctgaccg atacaaccct atcggcctcc      120

agccaaaacc tgctggagcg tgtggatcaa ctttgtctga ctatctttat tgttgaaata      180

tccctgaaaa tatacgccta tggcgtgcga ggctttttcc gcagcggctg gaatctgttt      240

gattttgtga ttgtggccat cgcgcttatg cccgcccagg gtagcctatc ggtgctgcga      300

accttccgta tattccgcgt catgcggctc gtatcggtca taccaaccat gcgaagagtg      360

gtgcaaggca tgctcttggc actgcccggc gtgggatcgg tagcggcact gttgacggtg      420

gtcttctata ttgcggctgt catggccacc aatctctacg gggcaacctt ccctgaatgg      480

tttggtgatc ttagcaagag cctgtacaca ctatttcagg tgatgacctt agagtcatgg      540

tctatgggca ttgtgcgtcc agtgatgaac gttcatccca acgcatgggt ttttttcatc      600

cccttcatca tgctcaccac ctttaccgtg ctcaacctgt ttattggcat tattgtagat      660

gccatggcca tcaccaagga acaggaggaa gaggccaaaa ccggccacca ccaagagcct      720

attagccaaa cattgctcca tctgggagat cgcctagata ggatcgaaaa gcagcttgcg      780

caaaacaacg agctcttaca acgacaacag ccgcaaaaaa aatag                      825


<210>  18
<211>  954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Magnetococcus marinus, codon optimized, with N-terminal 3x HA tag
       and linker:

<400>  18
atggtttatc cgtatgatgt tcctgactat gcaggatcct atccttatga tgttcccgat       60

tacgctggtt cttaccctta cgatgttccc gattatgcca gttctggatt ggtgccacga      120

ggcagccaca tgagccggaa gatcagagat cttatcgaat ctaagagatt tcagaatgtt      180

attaccgcga taatcgtact caacggggcg gtgctcggtc tcctcaccga taccacattg      240

agcgcttcta gccagaacct gctcgaaagg gttgaccaac tgtgcctgac aatttttatc      300

gtggaaatta gcttgaaaat ttacgcctac ggcgttcgcg gttttttccg gagcggttgg      360

aatctttttg acttcgttat cgttgccatc gcgctcatgc ccgcacaggg ttctttgtct      420

gtgttgagga cattccgaat atttcgcgtg atgcgcttgg tatccgtgat ccctacgatg      480

cgccgcgtcg tacaaggaat gttgctggct ctccccggcg tcgggagcgt tgctgccctc      540

cttaccgtgg tattttacat agcggcggtt atggctacta atctttacgg agctaccttc      600

ccggagtggt tcggggattt gtccaagagc ctctatacat tgtttcaagt tatgaccctg      660

gagtcctggt ctatgggcat tgtccggccc gtaatgaacg tacacccaaa tgcgtgggtg      720

tttttcattc cattcatcat gctgactacc tttaccgtgc tgaacttgtt cattgggatt      780

atcgtggatg cgatggccat cactaaggag caagaagaag aggctaaaac tggccaccac      840

caagagccaa tttctcaaac cctcttgcat ctcggggacc gactggaccg cattgagaag      900

caactcgcgc agaacaatga gctgttgcag cgacagcaac ctcaaaaaaa ataa            954


<210>  19
<211>  885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Magnetococcus marinus

<400>  19
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60

atgtcacgca aaatccgcga tttaatcgaa tccaaacgct ttcaaaacgt catcaccgcc      120

attattgtgc tcaatggcgc tgtgctgggt ctgctgaccg atacaaccct gtcggcctcc      180

agccaaaacc tgctggagcg tgtggatcaa ctttgtctga ctatctttat tgttgaaatc      240

tccctgaaaa tctacgccta tggcgtgcgc ggctttttcc gcagcggctg gaatctgttt      300

gattttgtga ttgtggccat cgcgcttatg ccggcccagg gtagcctgtc ggtgctgcgt      360

accttccgta tcttccgcgt catgcgcctc gtatcggtca tcccaaccat gcgccgtgtg      420

gtgcaaggca tgctcttggc actgccgggc gtgggctcgg tagcggcact gttgacggtg      480

gtcttctata ttgcggctgt catggccacc aatctctacg gggcaacctt ccctgaatgg      540

tttggtgatc ttagcaagag cctgtacaca ctgtttcagg tgatgacctt agagtcatgg      600

tctatgggca ttgtgcgtcc agtgatgaac gttcatccga acgcatgggt ttttttcatc      660

ccgttcatca tgctcaccac ctttaccgtg ctcaacctgt ttattggcat tattgtagat      720

gcaatggcaa tcaccaagga acaggaggaa gaggccaaaa ccggtcacca tcaagaacct      780

atttctcaaa ctcttcttca tcttggtgat cgtcttgatc gtattgaaaa acaacttgct      840

caaaataatg aacttcttca acgtcaacaa cctcaaaaaa aataa                      885


<210>  20
<211>  855
<212>  DNA
<213>  Bacillus pseudofirmus

<400>  20
atggaaaaca atccagccga acaacaagtt ccaccattag tagccttagc tcagcgtatc       60

gtctttcata aggcctttac cccaactatt attaccttga ttatcattaa tgccattatt      120

gtaggccttg aaacatatcc tactgtttat caaggttata atgattggtt ctacgcagca      180

gatttagcct tactttggat ttttacaatt gagattacac tgcgttttat cgcagcgaga      240

ccgactaaat ctttttttaa aagcagctgg aactggtttg atttattaat cgttcttgcc      300

ggtcatgtct ttgccggtgc tcattttgta acggttcttc gtatcctgcg cgttcttcgc      360

gtattacgtg ccatttctgt cattccttct ctgcgtcgtt tagtcgatgc tttgctgatg      420

accatcccgg ctttaggaaa cattatgatc ctgatgggaa ttattttcta tattttcgct      480

gtgattggaa cgatgttatt tgcttctgta gcacctgagt actttggtaa cttacagctt      540

tctttattaa cattattcca agttgttaca cttgaatctt gggcaagcgg tgtcatgagg      600

ccgatttttg cagaggtttg gtggtcttgg atttattttg tcatctttat tttagtaggg      660

acatttattg tctttaactt atttatcggt gttatcgtta ataacgttga aaaagcaaac      720

gaagaagaac tcaaatcaga attagatgat aaagaggcag atacaaaaga agagcttgct      780

tctctgcgta atgaagtagc agagatgaaa gacctcatta aacaaatgca taaacagcaa      840

acaaaaaaag ggtaa                                                       855


<210>  21
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bacillus pseudofirmus, codon optimized, with N-terminal 3x HA tag

<400>  21
atggtttacc cgtatgatgt cccggattac gctggcagct acccatacga tgtacccgac       60

tatgccggca gttatcccta cgacgtccct gactacgcag aaaacaaccc agccgaacag      120

caagtcccac ccctcgtggc gctcgcccaa cgcatagtat ttcacaaggc gtttacgccg      180

acgataatca ccctcatcat tattaatgcg atcattgtgg gactcgagac atacccaacg      240

gtttaccagg gttacaatga ttggttctat gctgccgacc ttgctttgtt gtggatattc      300

actattgaaa tcacgctccg attcatcgcc gcccgaccga cgaagagttt cttcaagtct      360

agctggaact ggtttgatct gcttatcgta ttggcgggcc acgtcttcgc tggcgcccat      420

tttgttacgg tgcttaggat cctccgcgtc ctgagggtcc tcagagctat ctcagtcata      480

cccagtctcc ggcggctggt tgacgcactt ttgatgacaa tcccagcact cggtaacatc      540

atgatactga tggggattat tttttacata ttcgcggtta tcgggacgat gctctttgca      600

tcagtagcgc cagaatactt tggcaatttg cagctgtctc tgcttacact gttccaagtg      660

gttacgctgg aaagttgggc tagtggggtt atgcgaccta tttttgccga agtctggtgg      720

tcttggatct attttgtaat ctttattctc gtgggaactt tcatagtatt taaccttttc      780

attggcgtca tcgtgaacaa tgtggaaaaa gctaacgaag aggaactgaa aagcgaactg      840

gatgataaag aggctgatac aaaagaagaa ctggcatcat tgcgaaacga ggtggcagaa      900

atgaaggatc tcataaaaca gatgcataaa cagcaaacaa aaaagggtta a               951


<210>  22
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Shewanella putrifaciens-D60N, codon optimized, with N-terminal 3x
       HA tag

<400>  22
atggtttacc cgtatgatgt cccggattac gctggcagct acccatacga tgtacccgac       60

tatgccggca gttatcccta cgacgtccct gactacgcat ctacgtccct tttgaatgcg      120

cctaccggcc ttcaagctag agtcattaat ctcgtcgaac aaaactggtt tggacacttt      180

atactgactc tcatactcat taatgctgtg cagcttggaa tggaaactag cgccagcctc      240

atggcacaat atggcgcgct gcttatgtcc ttgaataagg tccttctctc tgtgttcgtg      300

gtcgaactgc tgctccggat ttatgcgtat cggggcaagt tttttaagga cccgtggaat      360

gtgtttgact tcactgttat tgttattgct ctgattcctg catctggccc attggctgtc      420

ctccgctccc tccgagttct ccgcgtcttg agggttctga cgattgtccc cagcatgaaa      480

agagtagtgt cagcactgct tgggagcttg cccgggttgg cctccattgc aaccgtgctt      540

ctgttgatct attacgtttt cgctgtgatc gccactaaaa ttttcgggga tgcttttccg      600

gaatggttcg ggacgatagc ggactccttc tatacccttt ttcaaattat gaccttggaa      660

agttggtcta tggggatctc taggccagtg atggaggtgt acccttacgc ttgggtattc      720

tttgtgccct ttattcttgt tgctactttt accatgctta accttttcat cgccatcata      780

gtgaatacta tgcagacatt ctctgacgag gaacatgctc tggagcgaga gcaagataaa      840

cagatcttgg aacaggagca gagacaaatg cacgaggaac tgaaggccat tcgactcgag      900

cttcagcaac tccaaaccct tttgcgaaat gcggctgggg actcctccaa tgtctccaca      960

aagggcaata tcggctcaga ctaa                                             984


<210>  23
<211>  888
<212>  DNA
<213>  Shewanella putrifaciens

<400>  23
atgagtacat ctttacttaa cgcgccaacg ggtttgcagg cacgagtgat taacttggtt       60

gagcaaaact ggtttggtca ttttattttg acattgattt taatcaacgc ggtgcagtta      120

ggtatggaga cctcagccag cctgatggcg caatacggtg ctttgttgat gagtcttgat      180

aaggtgctgc tgagtgtatt tgtggtggag ttattgctgc ggatttatgc ctacaggggg      240

aaatttttta aagacccttg gaacgtgttc gattttaccg tgatagtgat agcactgatc      300

cctgcatctg ggccattggc tgtcctgcgt tcgctcaggg tattgcgggt gctgagagtg      360

ttaacaattg tgccatcaat gaaacgggtg gtgtctgcgc tgttgggatc acttcctgga      420

ttggcatcga tcgccacagt attactgctg atttattatg tgtttgcggt gatcgctacc      480

aaaatttttg gcgatgcatt ccctgaatgg tttggcacta ttgctgactc attttatacc      540

ctatttcaaa taatgacgct tgaaagctgg tctatgggaa tttcgcggcc agtgatggaa      600

gtctaccctt atgcttgggt atttttcgta ccatttattc tggtagcgac tttcacaatg      660

ctaaatttgt ttattgcgat tatcgtcaat accatgcaaa ccttcagcga cgaagagcat      720

gcattagagc gtgagcaaga caaacaaatc ttagagcagg aacaaagaca aatgcacgag      780

gagttgaaag ccatcagact cgagctacaa caattacaaa ccttgctgcg caatgctgct      840

ggtgattctt ctaatgtgtc gacaaaggga aacattggtt ctgactaa                   888


<210>  24
<211>  246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE3

<400>  24
ataatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg       60

ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc      120

gtatggcttt cattttctcc tccttgtata aatcctggtt agttcttgcc acggcggaac      180

tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc actgacaatt      240

ccgtgg                                                                 246


<210>  25
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGHpA

<400>  25
cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga       60

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt      120

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg      180

attgggaaga caatagcagg catg                                             204


<210>  26
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  26
ggcagcggcg ccaccaactt cagcctgctg aagcaggccg gcgacgtgga ggagaacccc       60

ggccccggag ctagcgga                                                     78


<210>  27
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GSG) residues can be added to the 5' end of the peptide to 
       improve cleavage efficiency

<400>  27

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro Gly Ala Ser Gly 
            20                  25      


<210>  28
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GSG) residues can be added to the 5' end of the peptide to 
       improve cleavage efficiency

<400>  28

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  29
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GSG) residues can be added to the 5' end of the peptide to 
       improve cleavage efficiency

<400>  29

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro Pro 
            20                  


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GSG) residues can be added to the 5' end of the peptide to 
       improve cleavage efficiency

<400>  30

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  31
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N-terminal 3XHA tag

<400>  31
atggtttacc cgtatgatgt cccggattac gctggcagct acccatacga tgtacccgac       60

tatgccggca gttatcccta cgacgtccct gactacgca                              99


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal 3XHA tag

<400>  32

Met Val Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser Tyr Pro Tyr 
1               5                   10                  15      


Asp Val Pro Asp Tyr Ala Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr 
            20                  25                  30          


Ala 
    


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  change from AAV9 to PHP.eB capsid

<400>  33

Ser Asp Gly Thr Leu Ala Val Pro Phe Lys Ala 
1               5                   10      


<210>  34
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  34

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  35
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tet-Transactivator version 2 (tTA2)

<400>  35
atgtctagac tggacaagag caaagtcata aactctgctc tggaattact caatgaagtc       60

ggtatcgaag gcctgacgac aaggaaactc gctcaaaagc tgggagttga gcagcctacc      120

ctgtactggc acgtgaagaa caagcgggcc ctgctcgatg ccctggcaat cgagatgctg      180

gacaggcatc atacccactt ctgccccctg gaaggcgagt catggcaaga ctttctgcgg      240

aacaacgcca agtcattccg ctgtgctctc ctctcacatc gcgacggggc taaagtgcat      300

ctcggcaccc gcccaacaga gaaacagtac gaaaccctgg aaaatcagct cgcgttcctg      360

tgtcagcaag gcttctccct ggagaacgca ctgtacgctc tgtccgccgt gggccacttt      420

acactgggct gcgtattgga ggatcaggag catcaagtag caaaagagga aagagagaca      480

cctaccaccg attctatgcc cccacttctg agacaagcaa ttgagctgtt cgaccatcag      540

ggagccgaac ctgccttcct tttcggcctg gaactaatca tatgtggcct ggagaaacag      600

ctaaagtgcg aaagcggcgg gccggccgac gcccttgacg attttgactt agacatgctc      660

ccagccgatg cccttgacga ctttgacctt gatatgctgc ctgctgacgc tcttgacgat      720

tttgaccttg acatgctccc cgggtaa                                          747


<210>  36
<211>  2843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   rAAV: hI56i-minBglobin-His-NavMs-P2A-SYFP2-WPRE3-BGHpA

<400>  36
gcggccgcac gcgtataggt accgagctct atgcactcac agtggtttgg catgcatctg       60

gtgaattttt tttaacgaaa aattagtgtt ggtttcgatg tatggtagca ttctccctaa      120

cgtaatttga ataattcagc aaagccccac taccagctgt acttctgcag cctcttccat      180

tcttttcagc attataattt tggttaattt tcaattttag gtcctacgtc tctgcaattt      240

gtgtatgaat aacagaataa tttccctctt ttgtttcgcc tttcctgttc ctgaatctaa      300

ataaagatgg ctttttagta ttaaaagtgg aagaaaatta caggtaatta tctttgacgg      360

taaaaacgct gtaatcagcg ggctacatga aaaattactc taattatggc tgcatttaag      420

agaatggaaa aaaaccttct tgtggataaa aaccttaaat tgtccccaat gtctgcttca      480

aattggatgg cactgcagct ggaggctttg ttcagaattg atcctgggga gctacgaacc      540

caaagtttca cagtagggag ctcgggctgg gcataaaagt cagggcagag ccatctattg      600

cttacatttg cttctgggat ccagatcttt cgaagctagc gctaccggtc gccaccatgg      660

gcagcagcca tcatcatcat catcacagca gcggcctggt gccgcgcggc agccatatgt      720

cacgcaaaat ccgcgattta atcgaatcca aacgctttca aaacgtcatc accgccatta      780

ttgtgctcaa tggcgctgtg ctgggtctgc tgaccgatac aaccctgtcg gcctccagcc      840

aaaacctgct ggagcgtgtg gatcaacttt gtctgactat ctttattgtt gaaatctccc      900

tgaaaatcta cgcctatggc gtgcgcggct ttttccgcag cggctggaat ctgtttgatt      960

ttgtgattgt ggccatcgcg cttatgccgg cccagggtag cctgtcggtg ctgcgtacct     1020

tccgtatctt ccgcgtcatg cgcctcgtat cggtcatccc aaccatgcgc cgtgtggtgc     1080

aaggcatgct cttggcactg ccgggcgtgg gctcggtagc ggcactgttg acggtggtct     1140

tctatattgc ggctgtcatg gccaccaatc tctacggggc aaccttccct gaatggtttg     1200

gtgatcttag caagagcctg tacacactgt ttcaggtgat gaccttagag tcatggtcta     1260

tgggcattgt gcgtccagtg atgaacgttc atccgaacgc atgggttttt ttcatcccgt     1320

tcatcatgct caccaccttt accgtgctca acctgtttat tggcattatt gtagatgcaa     1380

tggcaatcac caaggaacag gaggaagagg ccaaaaccgg tcaccatcaa gaacctattt     1440

ctcaaactct tcttcatctt ggtgatcgtc ttgatcgtat tgaaaaacaa cttgctcaaa     1500

ataatgaact tcttcaacgt caacaacctc aaaaaaaagg cagcggcgcc accaacttca     1560

gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatggtg agcaagggcg     1620

aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc     1680

acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga     1740

agctgatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccctgg     1800

gctacggcgt gcagtgcttc gcccgctacc ccgaccacat gaagcagcac gacttcttca     1860

agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca     1920

actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc     1980

tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact     2040

acaacagcca caacgtctat atcaccgccg acaagcagaa gaacggcatc aaggccaact     2100

tcaagatccg ccacaacatc gaggacggcg gcgtgcagct cgccgaccac taccagcaga     2160

acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agctaccagt     2220

ccaagctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga     2280

ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtaagtcgac ggcgcgccgc     2340

ggccgcgaat tcgatatcat aatcaacctc tggattacaa aatttgtgaa agattgactg     2400

gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt     2460

atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttag     2520

ttcttgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc     2580

tgttgggcac tgacaattcc gtggctcgag agatcttcga ctgtgccttc tagttgccag     2640

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact     2700

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt     2760

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat     2820

gcacgtgcgg accgagcggc cgc                                             2843


<210>  37
<211>  2835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV:3xhI56iCore-minCMV-SYFP2-P2A-3xHA-NavSheP-D60N-WPRE3-BGHpA

<400>  37
gcggccgcac gcgtggtacc ctaaataaag atggcttttt agtattaaaa gtggaagaaa       60

attacaggta attatctttg acggtaaaaa cgctgtaatc agcgggctac atgaaaaatt      120

actctaatta tggctgcatt taagagaatg gctaaataaa gatggctttt tagtattaaa      180

agtggaagaa aattacaggt aattatcttt gacggtaaaa acgctgtaat cagcgggcta      240

catgaaaaat tactctaatt atggctgcat ttaagagaat ggctaaataa agatggcttt      300

ttagtattaa aagtggaaga aaattacagg taattatctt tgacggtaaa aacgctgtaa      360

tcagcgggct acatgaaaaa ttactctaat tatggctgca tttaagagaa tggagctcgg      420

gctggtcgac acaattggag gtaggcgtgt acggtgggag gcctatataa gcagagctcg      480

tttagtgaac cgtcagatcg cctggaggat ccttcgaaaa gcttgctacc ggtcgccacc      540

atggtcagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac      600

ggcgacgtca atggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      660

ggcaagctga ccctgaagct gatctgcacc accggcaagc tgcccgtgcc ctggcccacc      720

ctcgtgacca ccctgggcta cggcgtgcag tgcttcgccc gctaccccga ccacatgaag      780

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      840

ttcaaagacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      900

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      960

aagctggagt acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac     1020

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc     1080

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac     1140

tacctgagct accagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc     1200

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaaaggc     1260

agcggcgcca ccaacttcag cctgctgaag caggccggcg acgtggagga gaaccccggc     1320

cccggagcta gcggaatggt ttacccgtat gatgtcccgg attacgctgg cagctaccca     1380

tacgatgtac ccgactatgc cggcagttat ccctacgacg tccctgacta cgcatctacg     1440

tcccttttga atgcgcctac cggccttcaa gctagagtca ttaatctcgt cgaacaaaac     1500

tggtttggac actttatact gactctcata ctcattaatg ctgtgcagct tggaatggaa     1560

actagcgcca gcctcatggc acaatatggc gcgctgctta tgtccttgaa taaggtcctt     1620

ctctctgtgt tcgtggtcga actgctgctc cggatttatg cgtatcgggg caagtttttt     1680

aaggacccgt ggaatgtgtt tgacttcact gttattgtta ttgctctgat tcctgcatct     1740

ggcccattgg ctgtcctccg ctccctccga gttctccgcg tcttgagggt tctgacgatt     1800

gtccccagca tgaaaagagt agtgtcagca ctgcttggga gcttgcccgg gttggcctcc     1860

attgcaaccg tgcttctgtt gatctattac gttttcgctg tgatcgccac taaaattttc     1920

ggggatgctt ttccggaatg gttcgggacg atagcggact ccttctatac cctttttcaa     1980

attatgacct tggaaagttg gtctatgggg atctctaggc cagtgatgga ggtgtaccct     2040

tacgcttggg tattctttgt gccctttatt cttgttgcta cttttaccat gcttaacctt     2100

ttcatcgcca tcatagtgaa tactatgcag acattctctg acgaggaaca tgctctggag     2160

cgagagcaag ataaacagat cttggaacag gagcagagac aaatgcacga ggaactgaag     2220

gccattcgac tcgagcttca gcaactccaa acccttttgc gaaatgcggc tggggactcc     2280

tccaatgtct ccacaaaggg caatatcggc tcagactaat gaccgcggcc gcgaattcga     2340

tatcataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat     2400

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct     2460

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttagttct tgccacggcg     2520

gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac     2580

aattccgtgg ctcgagagat cttcgactgt gccttctagt tgccagccat ctgttgtttg     2640

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2700

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     2760

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgaga tctcacgtgc     2820

ggaccgagcg gccgc                                                      2835


<210>  38
<211>  2802
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV: 3xhI56iCore-minCMV-SYFP2-P2A-3xHA-NavBp-WPRE3-BGHpA

<400>  38
gcggccgcac gcgtggtacc ctaaataaag atggcttttt agtattaaaa gtggaagaaa       60

attacaggta attatctttg acggtaaaaa cgctgtaatc agcgggctac atgaaaaatt      120

actctaatta tggctgcatt taagagaatg gctaaataaa gatggctttt tagtattaaa      180

agtggaagaa aattacaggt aattatcttt gacggtaaaa acgctgtaat cagcgggcta      240

catgaaaaat tactctaatt atggctgcat ttaagagaat ggctaaataa agatggcttt      300

ttagtattaa aagtggaaga aaattacagg taattatctt tgacggtaaa aacgctgtaa      360

tcagcgggct acatgaaaaa ttactctaat tatggctgca tttaagagaa tggagctcgg      420

gctggtcgac acaattggag gtaggcgtgt acggtgggag gcctatataa gcagagctcg      480

tttagtgaac cgtcagatcg cctggaggat ccttcgaaaa gcttgctacc ggtcgccacc      540

atggtcagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac      600

ggcgacgtca atggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      660

ggcaagctga ccctgaagct gatctgcacc accggcaagc tgcccgtgcc ctggcccacc      720

ctcgtgacca ccctgggcta cggcgtgcag tgcttcgccc gctaccccga ccacatgaag      780

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      840

ttcaaagacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      900

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      960

aagctggagt acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac     1020

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc     1080

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac     1140

tacctgagct accagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc     1200

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaaaggc     1260

agcggcgcca ccaacttcag cctgctgaag caggccggcg acgtggagga gaaccccggc     1320

cccggagcta gcggaatggt ttacccgtat gatgtcccgg attacgctgg cagctaccca     1380

tacgatgtac ccgactatgc cggcagttat ccctacgacg tccctgacta cgcagaaaac     1440

aacccagccg aacagcaagt cccacccctc gtggcgctcg cccaacgcat agtatttcac     1500

aaggcgttta cgccgacgat aatcaccctc atcattatta atgcgatcat tgtgggactc     1560

gagacatacc caacggttta ccagggttac aatgattggt tctatgctgc cgaccttgct     1620

ttgttgtgga tattcactat tgaaatcacg ctccgattca tcgccgcccg accgacgaag     1680

agtttcttca agtctagctg gaactggttt gatctgctta tcgtattggc gggccacgtc     1740

ttcgctggcg cccattttgt tacggtgctt aggatcctcc gcgtcctgag ggtcctcaga     1800

gctatctcag tcatacccag tctccggcgg ctggttgacg cacttttgat gacaatccca     1860

gcactcggta acatcatgat actgatgggg attatttttt acatattcgc ggttatcggg     1920

acgatgctct ttgcatcagt agcgccagaa tactttggca atttgcagct gtctctgctt     1980

acactgttcc aagtggttac gctggaaagt tgggctagtg gggttatgcg acctattttt     2040

gccgaagtct ggtggtcttg gatctatttt gtaatcttta ttctcgtggg aactttcata     2100

gtatttaacc ttttcattgg cgtcatcgtg aacaatgtgg aaaaagctaa cgaagaggaa     2160

ctgaaaagcg aactggatga taaagaggct gatacaaaag aagaactggc atcattgcga     2220

aacgaggtgg cagaaatgaa ggatctcata aaacagatgc ataaacagca aacaaaaaag     2280

ggttaatgac cgcggccgcg aattcgatat cataatcaac ctctggatta caaaatttgt     2340

gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct     2400

ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat     2460

aaatcctggt tagttcttgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg     2520

acaggggctc ggctgttggg cactgacaat tccgtggctc gagagatctt cgactgtgcc     2580

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     2640

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     2700

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     2760

caatagcagg catgagatct cacgtgcgga ccgagcggcc gc                        2802


<210>  39
<211>  2805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV: 3xhI56iCore-minCMV-SYFP2-P2A-3xHA-NavMs-WPRE3-BGHpA

<400>  39
gcggccgcac gcgtggtacc ctaaataaag atggcttttt agtattaaaa gtggaagaaa       60

attacaggta attatctttg acggtaaaaa cgctgtaatc agcgggctac atgaaaaatt      120

actctaatta tggctgcatt taagagaatg gctaaataaa gatggctttt tagtattaaa      180

agtggaagaa aattacaggt aattatcttt gacggtaaaa acgctgtaat cagcgggcta      240

catgaaaaat tactctaatt atggctgcat ttaagagaat ggctaaataa agatggcttt      300

ttagtattaa aagtggaaga aaattacagg taattatctt tgacggtaaa aacgctgtaa      360

tcagcgggct acatgaaaaa ttactctaat tatggctgca tttaagagaa tggagctcgg      420

gctggtcgac acaattggag gtaggcgtgt acggtgggag gcctatataa gcagagctcg      480

tttagtgaac cgtcagatcg cctggaggat ccttcgaaaa gcttgctacc ggtcgccacc      540

atggtcagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac      600

ggcgacgtca atggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      660

ggcaagctga ccctgaagct gatctgcacc accggcaagc tgcccgtgcc ctggcccacc      720

ctcgtgacca ccctgggcta cggcgtgcag tgcttcgccc gctaccccga ccacatgaag      780

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      840

ttcaaagacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      900

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      960

aagctggagt acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac     1020

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc     1080

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac     1140

tacctgagct accagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc     1200

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaaaggc     1260

agcggcgcca ccaacttcag cctgctgaag caggccggcg acgtggagga gaaccccggc     1320

cccggagcta gcggaatggt ttatccgtat gatgttcctg actatgcagg atcctatcct     1380

tatgatgttc ccgattacgc tggttcttac ccttacgatg ttcccgatta tgccagttct     1440

ggattggtgc cacgaggcag ccacatgagc cggaagatca gagatcttat cgaatctaag     1500

agatttcaga atgttattac cgcgataatc gtactcaacg gggcggtgct cggtctcctc     1560

accgatacca cattgagcgc ttctagccag aacctgctcg aaagggttga ccaactgtgc     1620

ctgacaattt ttatcgtgga aattagcttg aaaatttacg cctacggcgt tcgcggtttt     1680

ttccggagcg gttggaatct ttttgacttc gttatcgttg ccatcgcgct catgcccgca     1740

cagggttctt tgtctgtgtt gaggacattc cgaatatttc gcgtgatgcg cttggtatcc     1800

gtgatcccta cgatgcgccg cgtcgtacaa ggaatgttgc tggctctccc cggcgtcggg     1860

agcgttgctg ccctccttac cgtggtattt tacatagcgg cggttatggc tactaatctt     1920

tacggagcta ccttcccgga gtggttcggg gatttgtcca agagcctcta tacattgttt     1980

caagttatga ccctggagtc ctggtctatg ggcattgtcc ggcccgtaat gaacgtacac     2040

ccaaatgcgt gggtgttttt cattccattc atcatgctga ctacctttac cgtgctgaac     2100

ttgttcattg ggattatcgt ggatgcgatg gccatcacta aggagcaaga agaagaggct     2160

aaaactggcc accaccaaga gccaatttct caaaccctct tgcatctcgg ggaccgactg     2220

gaccgcattg agaagcaact cgcgcagaac aatgagctgt tgcagcgaca gcaacctcaa     2280

aaaaaataat gaccgcggcc gcgaattcga tatcataatc aacctctgga ttacaaaatt     2340

tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct     2400

gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg     2460

tataaatcct ggttagttct tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc     2520

tggacagggg ctcggctgtt gggcactgac aattccgtgg ctcgagagat cttcgactgt     2580

gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga     2640

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag     2700

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     2760

agacaatagc aggcatgaga tctcacgtgc ggaccgagcg gccgc                     2805


<210>  40
<211>  1901
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV: hI56i-minBglobin-SYFP2-WPRE3-BGHpA

<400>  40
gcggccgcac gcgtataggt accgagctct atgcactcac agtggtttgg catgcatctg       60

gtgaattttt tttaacgaaa aattagtgtt ggtttcgatg tatggtagca ttctccctaa      120

cgtaatttga ataattcagc aaagccccac taccagctgt acttctgcag cctcttccat      180

tcttttcagc attataattt tggttaattt tcaattttag gtcctacgtc tctgcaattt      240

gtgtatgaat aacagaataa tttccctctt ttgtttcgcc tttcctgttc ctgaatctaa      300

ataaagatgg ctttttagta ttaaaagtgg aagaaaatta caggtaatta tctttgacgg      360

taaaaacgct gtaatcagcg ggctacatga aaaattactc taattatggc tgcatttaag      420

agaatggaaa aaaaccttct tgtggataaa aaccttaaat tgtccccaat gtctgcttca      480

aattggatgg cactgcagct ggaggctttg ttcagaattg atcctgggga gctacgaacc      540

caaagtttca cagtagggag ctcgggctgg gcataaaagt cagggcagag ccatctattg      600

cttacatttg cttctgggat ccagatcttt cgaagctagc gctaccggtc gccaccatgg      660

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg      720

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca      780

agctgaccct gaagctgatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg      840

tgaccaccct gggctacggc gtgcagtgct tcgcccgcta ccccgaccac atgaagcagc      900

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca      960

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     1020

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     1080

tggagtacaa ctacaacagc cacaacgtct atatcaccgc cgacaagcag aagaacggca     1140

tcaaggccaa cttcaagatc cgccacaaca tcgaggacgg cggcgtgcag ctcgccgacc     1200

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     1260

tgagctacca gtccaagctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     1320

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaagtcg     1380

acggcgcgcc gcggccgcga attcgatatc ataatcaacc tctggattac aaaatttgtg     1440

aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt     1500

taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata     1560

aatcctggtt agttcttgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga     1620

caggggctcg gctgttgggc actgacaatt ccgtggctcg agagatcttc gactgtgcct     1680

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     1740

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     1800

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     1860

aatagcaggc atgagatctc acgtgcggac cgagcggccg c                         1901


<210>  41
<211>  4398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV: hI56core-minBglobin-SYFP2-WPRE3-BGHpA

<400>  41
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgttcgcc tttcctgttc ctgaatctaa      180

ataaagatgg ctttttagta ttaaaagtgg aagaaaatta caggtaatta tctttgacgg      240

taaaaacgct gtaatcagcg ggctacatga aaaattactc taattatggc tgcatttaag      300

agaatggacc tgcagggagc tcgggctggg cataaaagtc agggcagagc catctattgc      360

ttacatttgc ttctgggatc cagatctttc gaagctagcg ctaccggtcg ccaccatggt      420

gagcaagggc gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga      480

cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa      540

gctgaccctg aagctgatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt      600

gaccaccctg ggctacggcg tgcagtgctt cgcccgctac cccgaccaca tgaagcagca      660

cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa      720

ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa      780

ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct      840

ggagtacaac tacaacagcc acaacgtcta tatcaccgcc gacaagcaga agaacggcat      900

caaggccaac ttcaagatcc gccacaacat cgaggacggc ggcgtgcagc tcgccgacca      960

ctaccagcag aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct     1020

gagctaccag tccaagctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct     1080

ggagttcgtg accgccgccg ggatcactct cggcatggac gagctgtaca agtaagtcga     1140

cggcgcgccg cggccgcgaa ttcgatatca taatcaacct ctggattaca aaatttgtga     1200

aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt     1260

aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa     1320

atcctggtta gttcttgcca cggcggaact catcgccgcc tgccttgccc gctgctggac     1380

aggggctcgg ctgttgggca ctgacaattc cgtggctcga gagatcttcg actgtgcctt     1440

ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg     1500

ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt     1560

gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca     1620

atagcaggca tgagatctca cgtgcggacc gagcggccgc aggaacccct agtgatggag     1680

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     1740

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag     1800

gggcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatacgt     1860

caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     1920

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     1980

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     2040

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat ttgggtgatg     2100

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     2160

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcgggct     2220

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     2280

tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt ttatggtgca     2340

ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac     2400

ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga     2460

ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac     2520

gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt     2580

agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct     2640

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat     2700

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg     2760

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     2820

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     2880

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat     2940

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact     3000

attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca     3060

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact     3120

tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg     3180

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg     3240

agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg     3300

aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg     3360

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag     3420

ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc     3480

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga     3540

tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat     3600

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc     3660

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag     3720

accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct     3780

gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac     3840

caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc     3900

tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg     3960

ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt     4020

tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt     4080

gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc     4140

tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca     4200

gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata     4260

gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg     4320

ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct     4380

ggccttttgc tcacatgt                                                   4398


<210>  42
<211>  4635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV: 3XhI56core-minBglobin-SYFP2-WPRE3-BGHpA

<400>  42
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtggtac cctaaataaa gatggctttt      180

tagtattaaa agtggaagaa aattacaggt aattatcttt gacggtaaaa acgctgtaat      240

cagcgggcta catgaaaaat tactctaatt atggctgcat ttaagagaat ggctaaataa      300

agatggcttt ttagtattaa aagtggaaga aaattacagg taattatctt tgacggtaaa      360

aacgctgtaa tcagcgggct acatgaaaaa ttactctaat tatggctgca tttaagagaa      420

tggctaaata aagatggctt tttagtatta aaagtggaag aaaattacag gtaattatct      480

ttgacggtaa aaacgctgta atcagcgggc tacatgaaaa attactctaa ttatggctgc      540

atttaagaga atggagctcg ggctgggcat aaaagtcagg gcagagccat ctattgctta      600

catttgcttc tgggatccag atctttcgaa gctagcgcta ccggtcgcca ccatggtgag      660

caagggcgag gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt      720

aaacggccac aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct      780

gaccctgaag ctgatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac      840

caccctgggc tacggcgtgc agtgcttcgc ccgctacccc gaccacatga agcagcacga      900

cttcttcaag tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga      960

cgacggcaac tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg     1020

catcgagctg aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga     1080

gtacaactac aacagccaca acgtctatat caccgccgac aagcagaaga acggcatcaa     1140

ggccaacttc aagatccgcc acaacatcga ggacggcggc gtgcagctcg ccgaccacta     1200

ccagcagaac acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag     1260

ctaccagtcc aagctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga     1320

gttcgtgacc gccgccggga tcactctcgg catggacgag ctgtacaagt aagtcgacgg     1380

cgcgccgcgg ccgcgaattc gatatcataa tcaacctctg gattacaaaa tttgtgaaag     1440

attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat     1500

gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc     1560

ctggttagtt cttgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg     1620

ggctcggctg ttgggcactg acaattccgt ggctcgagag atcttcgact gtgccttcta     1680

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca     1740

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc     1800

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata     1860

gcaggcatga gatctcacgt gcggaccgag cggccgcagg aacccctagt gatggagttg     1920

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga     1980

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg cctgcagggg     2040

cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catacgtcaa     2100

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc     2160

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt     2220

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag     2280

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgatttg ggtgatggtt     2340

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt     2400

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcgggctatt     2460

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt     2520

aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttta tggtgcactc     2580

tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg     2640

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg     2700

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa     2760

agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga     2820

cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa     2880

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt     2940

gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg     3000

cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag     3060

atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg     3120

agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg     3180

gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt     3240

ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga     3300

cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac     3360

ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc     3420

atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc     3480

gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac     3540

tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag     3600

gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg     3660

gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta     3720

tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg     3780

ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata     3840

tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt     3900

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc     3960

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct     4020

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa     4080

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag     4140

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc     4200

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg     4260

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca     4320

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat     4380

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     4440

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     4500

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     4560

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc     4620

cttttgctca catgt                                                      4635


<210>  43
<211>  4841
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV: hI56i-minBglobin-SYFP2-WPRE3-BGHpA

<400>  43
aaagcttccc ggggggatct gggccactcc ctctctgcgc gctcgctcgc tcactgaggc       60

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg      120

agcgcgcaga gagggagtgg ccaactccat cactaggggt tcctggaggg gtggagtcgt      180

gacctaggac gcgtataggt accgagctct atgcactcac agtggtttgg catgcatctg      240

gtgaattttt tttaacgaaa aattagtgtt ggtttcgatg tatggtagca ttctccctaa      300

cgtaatttga ataattcagc aaagccccac taccagctgt acttctgcag cctcttccat      360

tcttttcagc attataattt tggttaattt tcaattttag gtcctacgtc tctgcaattt      420

gtgtatgaat aacagaataa tttccctctt ttgtttcgcc tttcctgttc ctgaatctaa      480

ataaagatgg ctttttagta ttaaaagtgg aagaaaatta caggtaatta tctttgacgg      540

taaaaacgct gtaatcagcg ggctacatga aaaattactc taattatggc tgcatttaag      600

agaatggaaa aaaaccttct tgtggataaa aaccttaaat tgtccccaat gtctgcttca      660

aattggatgg cactgcagct ggaggctttg ttcagaattg atcctgggga gctacgaacc      720

caaagtttca cagtagggag ctcgggctgg gcataaaagt cagggcagag ccatctattg      780

cttacatttg cttctgggat ccagatcttt cgaagctagc gctaccggtc gccaccatgg      840

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg      900

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca      960

agctgaccct gaagctgatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg     1020

tgaccaccct gggctacggc gtgcagtgct tcgcccgcta ccccgaccac atgaagcagc     1080

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca     1140

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     1200

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     1260

tggagtacaa ctacaacagc cacaacgtct atatcaccgc cgacaagcag aagaacggca     1320

tcaaggccaa cttcaagatc cgccacaaca tcgaggacgg cggcgtgcag ctcgccgacc     1380

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     1440

tgagctacca gtccaagctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     1500

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaagtcg     1560

acggcgcgcc gcggccgcga attcgatatc ataatcaacc tctggattac aaaatttgtg     1620

aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt     1680

taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata     1740

aatcctggtt agttcttgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga     1800

caggggctcg gctgttgggc actgacaatt ccgtggctcg agcgactgtg ccttctagtt     1860

gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc     1920

ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt     1980

ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca     2040

ggcatgacta gtccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa     2100

aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag     2160

agggacagat ccgggcccgc atgcgtcgac aattcactgg ccgtcgtttt acaacgtcgt     2220

gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc     2280

agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg     2340

aatggcgaat ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac     2400

cgcatatggt gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga     2460

cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac     2520

agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg     2580

aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata     2640

ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt     2700

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa     2760

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt     2820

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa     2880

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac     2940

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt     3000

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt     3060

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat     3120

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac     3180

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg     3240

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc     3300

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa     3360

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag     3420

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct     3480

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat     3540

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa     3600

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     3660

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     3720

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     3780

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     3840

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     3900

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     3960

aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     4020

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     4080

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     4140

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     4200

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     4260

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     4320

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     4380

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     4440

ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg     4500

gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag     4560

cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc     4620

gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc     4680

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac     4740

tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga     4800

aacagctatg accatgatta cgccaagctc tcgagatcta g                         4841


<210>  44
<211>  1927
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Leu Ser Trp His Val Val Phe Ile Ala Leu Leu Ser Phe Ser 
1               5                   10                  15      


Cys Trp Gly Ser Asp Trp Glu Ser Asp Arg Asn Phe Ile Ser Thr Ala 
            20                  25                  30          


Gly Pro Leu Thr Asn Asp Leu Leu His Asn Leu Ser Gly Leu Leu Gly 
        35                  40                  45              


Asp Gln Ser Ser Asn Phe Val Ala Gly Asp Lys Asp Met Tyr Val Cys 
    50                  55                  60                  


His Gln Pro Leu Pro Thr Phe Leu Pro Glu Tyr Phe Ser Ser Leu His 
65                  70                  75                  80  


Ala Ser Gln Ile Thr His Tyr Lys Val Phe Leu Ser Trp Ala Gln Leu 
                85                  90                  95      


Leu Pro Ala Gly Ser Thr Gln Asn Pro Asp Glu Lys Thr Val Gln Cys 
            100                 105                 110         


Tyr Arg Arg Leu Leu Lys Ala Leu Lys Thr Ala Arg Leu Gln Pro Met 
        115                 120                 125             


Val Ile Leu His His Gln Thr Leu Pro Ala Ser Thr Leu Arg Arg Thr 
    130                 135                 140                 


Glu Ala Phe Ala Asp Leu Phe Ala Asp Tyr Ala Thr Phe Ala Phe His 
145                 150                 155                 160 


Ser Phe Gly Asp Leu Val Gly Ile Trp Phe Thr Phe Ser Asp Leu Glu 
                165                 170                 175     


Glu Val Ile Lys Glu Leu Pro His Gln Glu Ser Arg Ala Ser Gln Leu 
            180                 185                 190         


Gln Thr Leu Ser Asp Ala His Arg Lys Ala Tyr Glu Ile Tyr His Glu 
        195                 200                 205             


Ser Tyr Ala Phe Gln Gly Gly Lys Leu Ser Val Val Leu Arg Ala Glu 
    210                 215                 220                 


Asp Ile Pro Glu Leu Leu Leu Glu Pro Pro Ile Ser Ala Leu Ala Gln 
225                 230                 235                 240 


Asp Thr Val Asp Phe Leu Ser Leu Asp Leu Ser Tyr Glu Cys Gln Asn 
                245                 250                 255     


Glu Ala Ser Leu Arg Gln Lys Leu Ser Lys Leu Gln Thr Ile Glu Pro 
            260                 265                 270         


Lys Val Lys Val Phe Ile Phe Asn Leu Lys Leu Pro Asp Cys Pro Ser 
        275                 280                 285             


Thr Met Lys Asn Pro Ala Ser Leu Leu Phe Ser Leu Phe Glu Ala Ile 
    290                 295                 300                 


Asn Lys Asp Gln Val Leu Thr Ile Gly Phe Asp Ile Asn Glu Phe Leu 
305                 310                 315                 320 


Ser Cys Ser Ser Ser Ser Lys Lys Ser Met Ser Cys Ser Leu Thr Gly 
                325                 330                 335     


Ser Leu Ala Leu Gln Pro Asp Gln Gln Gln Asp His Glu Thr Thr Asp 
            340                 345                 350         


Ser Ser Pro Ala Ser Ala Tyr Gln Arg Val Trp Glu Ala Phe Ala Asn 
        355                 360                 365             


Gln Ser Arg Ala Glu Arg Asp Ala Phe Leu Gln Asp Thr Phe Pro Glu 
    370                 375                 380                 


Gly Phe Leu Trp Gly Ala Ser Thr Gly Ala Phe Asn Val Glu Gly Gly 
385                 390                 395                 400 


Trp Ala Glu Gly Gly Arg Gly Val Ser Ile Trp Asp Pro Arg Arg Pro 
                405                 410                 415     


Leu Asn Thr Thr Glu Gly Gln Ala Thr Leu Glu Val Ala Ser Asp Ser 
            420                 425                 430         


Tyr His Lys Val Ala Ser Asp Val Ala Leu Leu Cys Gly Leu Arg Ala 
        435                 440                 445             


Gln Val Tyr Lys Phe Ser Ile Ser Trp Ser Arg Ile Phe Pro Met Gly 
    450                 455                 460                 


His Gly Ser Ser Pro Ser Leu Pro Gly Val Ala Tyr Tyr Asn Lys Leu 
465                 470                 475                 480 


Ile Asp Arg Leu Gln Asp Ala Gly Ile Glu Pro Met Ala Thr Leu Phe 
                485                 490                 495     


His Trp Asp Leu Pro Gln Ala Leu Gln Asp His Gly Gly Trp Gln Asn 
            500                 505                 510         


Glu Ser Val Val Asp Ala Phe Leu Asp Tyr Ala Ala Phe Cys Phe Ser 
        515                 520                 525             


Thr Phe Gly Asp Arg Val Lys Leu Trp Val Thr Phe His Glu Pro Trp 
    530                 535                 540                 


Val Met Ser Tyr Ala Gly Tyr Gly Thr Gly Gln His Pro Pro Gly Ile 
545                 550                 555                 560 


Ser Asp Pro Gly Val Ala Ser Phe Lys Val Ala His Leu Val Leu Lys 
                565                 570                 575     


Ala His Ala Arg Thr Trp His His Tyr Asn Ser His His Arg Pro Gln 
            580                 585                 590         


Gln Gln Gly His Val Gly Ile Val Leu Asn Ser Asp Trp Ala Glu Pro 
        595                 600                 605             


Leu Ser Pro Glu Arg Pro Glu Asp Leu Arg Ala Ser Glu Arg Phe Leu 
    610                 615                 620                 


His Phe Met Leu Gly Trp Phe Ala His Pro Val Phe Val Asp Gly Asp 
625                 630                 635                 640 


Tyr Pro Ala Thr Leu Arg Thr Gln Ile Gln Gln Met Asn Arg Gln Cys 
                645                 650                 655     


Ser His Pro Val Ala Gln Leu Pro Glu Phe Thr Glu Ala Glu Lys Gln 
            660                 665                 670         


Leu Leu Lys Gly Ser Ala Asp Phe Leu Gly Leu Ser His Tyr Thr Ser 
        675                 680                 685             


Arg Leu Ile Ser Asn Ala Pro Gln Asn Thr Cys Ile Pro Ser Tyr Asp 
    690                 695                 700                 


Thr Ile Gly Gly Phe Ser Gln His Val Asn His Val Trp Pro Gln Thr 
705                 710                 715                 720 


Ser Ser Ser Trp Ile Arg Val Val Pro Trp Gly Ile Arg Arg Leu Leu 
                725                 730                 735     


Gln Phe Val Ser Leu Glu Tyr Thr Arg Gly Lys Val Pro Ile Tyr Leu 
            740                 745                 750         


Ala Gly Asn Gly Met Pro Ile Gly Glu Ser Glu Asn Leu Phe Asp Asp 
        755                 760                 765             


Ser Leu Arg Val Asp Tyr Phe Asn Gln Tyr Ile Asn Glu Val Leu Lys 
    770                 775                 780                 


Ala Ile Lys Glu Asp Ser Val Asp Val Arg Ser Tyr Ile Ala Arg Ser 
785                 790                 795                 800 


Leu Ile Asp Gly Phe Glu Gly Pro Ser Gly Tyr Ser Gln Arg Phe Gly 
                805                 810                 815     


Leu His His Val Asn Phe Ser Asp Ser Ser Lys Ser Arg Thr Pro Arg 
            820                 825                 830         


Lys Ser Ala Tyr Phe Phe Thr Ser Ile Ile Glu Lys Asn Gly Phe Leu 
        835                 840                 845             


Thr Lys Gly Ala Lys Arg Leu Leu Pro Pro Asn Thr Val Asn Leu Pro 
    850                 855                 860                 


Ser Lys Val Arg Ala Phe Thr Phe Pro Ser Glu Val Pro Ser Lys Ala 
865                 870                 875                 880 


Lys Val Val Trp Glu Lys Phe Ser Ser Gln Pro Lys Phe Glu Arg Asp 
                885                 890                 895     


Leu Phe Tyr His Gly Thr Phe Arg Asp Asp Phe Leu Trp Gly Val Ser 
            900                 905                 910         


Ser Ser Ala Tyr Gln Ile Glu Gly Ala Trp Asp Ala Asp Gly Lys Gly 
        915                 920                 925             


Pro Ser Ile Trp Asp Asn Phe Thr His Thr Pro Gly Ser Asn Val Lys 
    930                 935                 940                 


Asp Asn Ala Thr Gly Asp Ile Ala Cys Asp Ser Tyr His Gln Leu Asp 
945                 950                 955                 960 


Ala Asp Leu Asn Met Leu Arg Ala Leu Lys Val Lys Ala Tyr Arg Phe 
                965                 970                 975     


Ser Ile Ser Trp Ser Arg Ile Phe Pro Thr Gly Arg Asn Ser Ser Ile 
            980                 985                 990         


Asn Ser His Gly Val Asp Tyr Tyr  Asn Arg Leu Ile Asn  Gly Leu Val 
        995                 1000                 1005             


Ala Ser  Asn Ile Phe Pro Met  Val Thr Leu Phe His  Trp Asp Leu 
    1010                 1015                 1020             


Pro Gln  Ala Leu Gln Asp Ile  Gly Gly Trp Glu Asn  Pro Ala Leu 
    1025                 1030                 1035             


Ile Asp  Leu Phe Asp Ser Tyr  Ala Asp Phe Cys Phe  Gln Thr Phe 
    1040                 1045                 1050             


Gly Asp  Arg Val Lys Phe Trp  Met Thr Phe Asn Glu  Pro Met Tyr 
    1055                 1060                 1065             


Leu Ala  Trp Leu Gly Tyr Gly  Ser Gly Glu Phe Pro  Pro Gly Val 
    1070                 1075                 1080             


Lys Asp  Pro Gly Trp Ala Pro  Tyr Arg Ile Ala His  Ala Val Ile 
    1085                 1090                 1095             


Lys Ala  His Ala Arg Val Tyr  His Thr Tyr Asp Glu  Lys Tyr Arg 
    1100                 1105                 1110             


Gln Glu  Gln Lys Gly Val Ile  Ser Leu Ser Leu Ser  Thr His Trp 
    1115                 1120                 1125             


Ala Glu  Pro Lys Ser Pro Gly  Val Pro Arg Asp Val  Glu Ala Ala 
    1130                 1135                 1140             


Asp Arg  Met Leu Gln Phe Ser  Leu Gly Trp Phe Ala  His Pro Ile 
    1145                 1150                 1155             


Phe Arg  Asn Gly Asp Tyr Pro  Asp Thr Met Lys Trp  Lys Val Gly 
    1160                 1165                 1170             


Asn Arg  Ser Glu Leu Gln His  Leu Ala Thr Ser Arg  Leu Pro Ser 
    1175                 1180                 1185             


Phe Thr  Glu Glu Glu Lys Arg  Phe Ile Arg Ala Thr  Ala Asp Val 
    1190                 1195                 1200             


Phe Cys  Leu Asn Thr Tyr Tyr  Ser Arg Ile Val Gln  His Lys Thr 
    1205                 1210                 1215             


Pro Arg  Leu Asn Pro Pro Ser  Tyr Glu Asp Asp Gln  Glu Met Ala 
    1220                 1225                 1230             


Glu Glu  Glu Asp Pro Ser Trp  Pro Ser Thr Ala Met  Asn Arg Ala 
    1235                 1240                 1245             


Ala Pro  Trp Gly Thr Arg Arg  Leu Leu Asn Trp Ile  Lys Glu Glu 
    1250                 1255                 1260             


Tyr Gly  Asp Ile Pro Ile Tyr  Ile Thr Glu Asn Gly  Val Gly Leu 
    1265                 1270                 1275             


Thr Asn  Pro Asn Thr Glu Asp  Thr Asp Arg Ile Phe  Tyr His Lys 
    1280                 1285                 1290             


Thr Tyr  Ile Asn Glu Ala Leu  Lys Ala Tyr Arg Leu  Asp Gly Ile 
    1295                 1300                 1305             


Asp Leu  Arg Gly Tyr Val Ala  Trp Ser Leu Met Asp  Asn Phe Glu 
    1310                 1315                 1320             


Trp Leu  Asn Gly Tyr Thr Val  Lys Phe Gly Leu Tyr  His Val Asp 
    1325                 1330                 1335             


Phe Asn  Asn Thr Asn Arg Pro  Arg Thr Ala Arg Ala  Ser Ala Arg 
    1340                 1345                 1350             


Tyr Tyr  Thr Glu Val Ile Thr  Asn Asn Gly Met Pro  Leu Ala Arg 
    1355                 1360                 1365             


Glu Asp  Glu Phe Leu Tyr Gly  Arg Phe Pro Glu Gly  Phe Ile Trp 
    1370                 1375                 1380             


Ser Ala  Ala Ser Ala Ala Tyr  Gln Ile Glu Gly Ala  Trp Arg Ala 
    1385                 1390                 1395             


Asp Gly  Lys Gly Leu Ser Ile  Trp Asp Thr Phe Ser  His Thr Pro 
    1400                 1405                 1410             


Leu Arg  Val Glu Asn Asp Ala  Ile Gly Asp Val Ala  Cys Asp Ser 
    1415                 1420                 1425             


Tyr His  Lys Ile Ala Glu Asp  Leu Val Thr Leu Gln  Asn Leu Gly 
    1430                 1435                 1440             


Val Ser  His Tyr Arg Phe Ser  Ile Ser Trp Ser Arg  Ile Leu Pro 
    1445                 1450                 1455             


Asp Gly  Thr Thr Arg Tyr Ile  Asn Glu Ala Gly Leu  Asn Tyr Tyr 
    1460                 1465                 1470             


Val Arg  Leu Ile Asp Thr Leu  Leu Ala Ala Ser Ile  Gln Pro Gln 
    1475                 1480                 1485             


Val Thr  Ile Tyr His Trp Asp  Leu Pro Gln Thr Leu  Gln Asp Val 
    1490                 1495                 1500             


Gly Gly  Trp Glu Asn Glu Thr  Ile Val Gln Arg Phe  Lys Glu Tyr 
    1505                 1510                 1515             


Ala Asp  Val Leu Phe Gln Arg  Leu Gly Asp Lys Val  Lys Phe Trp 
    1520                 1525                 1530             


Ile Thr  Leu Asn Glu Pro Phe  Val Ile Ala Tyr Gln  Gly Tyr Gly 
    1535                 1540                 1545             


Tyr Gly  Thr Ala Ala Pro Gly  Val Ser Asn Arg Pro  Gly Thr Ala 
    1550                 1555                 1560             


Pro Tyr  Ile Val Gly His Asn  Leu Ile Lys Ala His  Ala Glu Ala 
    1565                 1570                 1575             


Trp His  Leu Tyr Asn Asp Val  Tyr Arg Ala Ser Gln  Gly Gly Val 
    1580                 1585                 1590             


Ile Ser  Ile Thr Ile Ser Ser  Asp Trp Ala Glu Pro  Arg Asp Pro 
    1595                 1600                 1605             


Ser Asn  Gln Glu Asp Val Glu  Ala Ala Arg Arg Tyr  Val Gln Phe 
    1610                 1615                 1620             


Met Gly  Gly Trp Phe Ala His  Pro Ile Phe Lys Asn  Gly Asp Tyr 
    1625                 1630                 1635             


Asn Glu  Val Met Lys Thr Arg  Ile Arg Asp Arg Ser  Leu Ala Ala 
    1640                 1645                 1650             


Gly Leu  Asn Lys Ser Arg Leu  Pro Glu Phe Thr Glu  Ser Glu Lys 
    1655                 1660                 1665             


Arg Arg  Ile Asn Gly Thr Tyr  Asp Phe Phe Gly Phe  Asn His Tyr 
    1670                 1675                 1680             


Thr Thr  Val Leu Ala Tyr Asn  Leu Asn Tyr Ala Thr  Ala Ile Ser 
    1685                 1690                 1695             


Ser Phe  Asp Ala Asp Arg Gly  Val Ala Ser Ile Ala  Asp Arg Ser 
    1700                 1705                 1710             


Trp Pro  Asp Ser Gly Ser Phe  Trp Leu Lys Met Thr  Pro Phe Gly 
    1715                 1720                 1725             


Phe Arg  Arg Ile Leu Asn Trp  Leu Lys Glu Glu Tyr  Asn Asp Pro 
    1730                 1735                 1740             


Pro Ile  Tyr Val Thr Glu Asn  Gly Val Ser Gln Arg  Glu Glu Thr 
    1745                 1750                 1755             


Asp Leu  Asn Asp Thr Ala Arg  Ile Tyr Tyr Leu Arg  Thr Tyr Ile 
    1760                 1765                 1770             


Asn Glu  Ala Leu Lys Ala Val  Gln Asp Lys Val Asp  Leu Arg Gly 
    1775                 1780                 1785             


Tyr Thr  Val Trp Ser Ala Met  Asp Asn Phe Glu Trp  Ala Thr Gly 
    1790                 1795                 1800             


Phe Ser  Glu Arg Phe Gly Leu  His Phe Val Asn Tyr  Ser Asp Pro 
    1805                 1810                 1815             


Ser Leu  Pro Arg Ile Pro Lys  Ala Ser Ala Lys Phe  Tyr Ala Ser 
    1820                 1825                 1830             


Val Val  Arg Cys Asn Gly Phe  Pro Asp Pro Ala Thr  Gly Pro His 
    1835                 1840                 1845             


Ala Cys  Leu His Gln Pro Asp  Ala Gly Pro Thr Ile  Ser Pro Val 
    1850                 1855                 1860             


Arg Gln  Glu Glu Val Gln Phe  Leu Gly Leu Met Leu  Gly Thr Thr 
    1865                 1870                 1875             


Glu Ala  Gln Thr Ala Leu Tyr  Val Leu Phe Ser Leu  Val Leu Leu 
    1880                 1885                 1890             


Gly Val  Cys Gly Leu Ala Phe  Leu Ser Tyr Lys Tyr  Cys Lys Arg 
    1895                 1900                 1905             


Ser Lys  Gln Gly Lys Thr Gln  Arg Ser Gln Gln Glu  Leu Ser Pro 
    1910                 1915                 1920             


Val Ser  Ser Phe 
    1925         


<210>  45
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Leu Pro Leu Trp Thr Leu Ser Leu Leu Leu Gly Ala Val Ala Gly 
1               5                   10                  15      


Lys Glu Val Cys Tyr Glu Arg Leu Gly Cys Phe Ser Asp Asp Ser Pro 
            20                  25                  30          


Trp Ser Gly Ile Thr Glu Arg Pro Leu His Ile Leu Pro Trp Ser Pro 
        35                  40                  45              


Lys Asp Val Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asn 
    50                  55                  60                  


Asn Phe Gln Glu Val Ala Ala Asp Ser Ser Ser Ile Ser Gly Ser Asn 
65                  70                  75                  80  


Phe Lys Thr Asn Arg Lys Thr Arg Phe Ile Ile His Gly Phe Ile Asp 
                85                  90                  95      


Lys Gly Glu Glu Asn Trp Leu Ala Asn Val Cys Lys Asn Leu Phe Lys 
            100                 105                 110         


Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Gly Gly Ser Arg 
        115                 120                 125             


Thr Gly Tyr Thr Gln Ala Ser Gln Asn Ile Arg Ile Val Gly Ala Glu 
    130                 135                 140                 


Val Ala Tyr Phe Val Glu Phe Leu Gln Ser Ala Phe Gly Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Val His Val Ile Gly His Ser Leu Gly Ala His Ala Ala Gly 
                165                 170                 175     


Glu Ala Gly Arg Arg Thr Asn Gly Thr Ile Gly Arg Ile Thr Gly Leu 
            180                 185                 190         


Asp Pro Ala Glu Pro Cys Phe Gln Gly Thr Pro Glu Leu Val Arg Leu 
        195                 200                 205             


Asp Pro Ser Asp Ala Lys Phe Val Asp Val Ile His Thr Asp Gly Ala 
    210                 215                 220                 


Pro Ile Val Pro Asn Leu Gly Phe Gly Met Ser Gln Val Val Gly His 
225                 230                 235                 240 


Leu Asp Phe Phe Pro Asn Gly Gly Val Glu Met Pro Gly Cys Lys Lys 
                245                 250                 255     


Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr 
            260                 265                 270         


Arg Asp Phe Ala Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Thr 
        275                 280                 285             


Asp Ser Ile Val Asn Pro Asp Gly Phe Ala Gly Phe Pro Cys Ala Ser 
    290                 295                 300                 


Tyr Asn Val Phe Thr Ala Asn Lys Cys Phe Pro Cys Pro Ser Gly Gly 
305                 310                 315                 320 


Cys Pro Gln Met Gly His Tyr Ala Asp Arg Tyr Pro Gly Lys Thr Asn 
                325                 330                 335     


Asp Val Gly Gln Lys Phe Tyr Leu Asp Thr Gly Asp Ala Ser Asn Phe 
            340                 345                 350         


Ala Arg Trp Arg Tyr Lys Val Ser Val Thr Leu Ser Gly Lys Lys Val 
        355                 360                 365             


Thr Gly His Ile Leu Val Ser Leu Phe Gly Asn Lys Gly Asn Ser Lys 
    370                 375                 380                 


Gln Tyr Glu Ile Phe Lys Gly Thr Leu Lys Pro Asp Ser Thr His Ser 
385                 390                 395                 400 


Asn Glu Phe Asp Ser Asp Val Asp Val Gly Asp Leu Gln Met Val Lys 
                405                 410                 415     


Phe Ile Trp Tyr Asn Asn Val Ile Asn Pro Thr Leu Pro Arg Val Gly 
            420                 425                 430         


Ala Ser Lys Ile Ile Val Glu Thr Asn Val Gly Lys Gln Phe Asn Phe 
        435                 440                 445             


Cys Ser Pro Glu Thr Val Arg Glu Glu Val Leu Leu Thr Leu Thr Pro 
    450                 455                 460                 


Cys 
465 


<210>  46
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Ile Ser Ser Leu Phe Gly Gly Arg Tyr Asp Asn Lys Phe Leu 
1               5                   10                  15      


Leu Asn Met Ser Ser Ala Pro Lys Ile Glu Leu Ile Val Asp Lys Val 
            20                  25                  30          


Ala Ser Leu Ser Glu Gly Arg Leu Glu Gly Arg Leu Pro Glu Asp Trp 
        35                  40                  45              


Phe Arg His Ile Met Asp Pro Glu Thr Glu Phe Asn Ser Glu Phe Ala 
    50                  55                  60                  


Asp Ala Leu Cys Ile Gly Ile Asp Glu Phe Ala Gln Pro Leu Pro Phe 
65                  70                  75                  80  


Leu Pro Phe Lys Ala Leu Leu Val Thr Gly Thr Ala Gly Ala Gly Lys 
                85                  90                  95      


Thr Asn Ser Ile Gln Thr Leu Ala Ala Asn Leu Asp Cys Ile Val Thr 
            100                 105                 110         


Ala Thr Thr Ser Ile Ala Ala Gln Asn Leu Ser Val Val Leu Asn Arg 
        115                 120                 125             


Ser Lys Ser Ala Gln Val Lys Thr Ile Phe Lys Thr Phe Gly Phe Asn 
    130                 135                 140                 


Ser Ser His Val Ser Met Ser Glu Arg Gln Ser Tyr Ile Ala Asn Asp 
145                 150                 155                 160 


Glu Arg Ser Ile Gln Ile Gln Gln Lys Gln Asp Leu Ser Ile Tyr Trp 
                165                 170                 175     


Asn Val Ile Ser Asp Ile Ala Asp Arg Ala Leu Gly Ala Val Ala Cys 
            180                 185                 190         


Lys Thr Lys Glu Leu Pro Asp Leu Cys Glu Ser Ser Val Ile Val Ile 
        195                 200                 205             


Asp Glu Ala Gly Val Ile Leu Arg His Ile Leu His Thr Val Val Phe 
    210                 215                 220                 


Phe Tyr Trp Phe Tyr Asn Ala Leu Tyr Lys Thr Pro Leu Tyr Glu Asp 
225                 230                 235                 240 


Gly Ile Val Pro Cys Ile Val Cys Val Gly Ser Pro Thr Gln Ser Asn 
                245                 250                 255     


Ala Leu Val Thr Ser Phe Asn Pro Leu Thr Gln Asn Lys Asp Val Lys 
            260                 265                 270         


Arg Gly Ile Asp Val Leu Ser Ala Leu Ile Cys Asp Asp Val Leu Ser 
        275                 280                 285             


Lys Tyr Cys Glu Val Asp Asn Asn Trp Ile Ile Phe Val Asn Asn Lys 
    290                 295                 300                 


Arg Cys Ala Asp His Ala Phe Gly Asp Phe Leu Lys His Ile Glu Phe 
305                 310                 315                 320 


Gly Leu Pro Leu Lys Pro Glu Leu Ile Glu Tyr Val Asp Gln Phe Val 
                325                 330                 335     


Lys Pro Ala Ser Tyr Ile Arg Asn Pro Met Asn Glu Ile Glu Thr Thr 
            340                 345                 350         


Arg Leu Phe Leu Ser His Asn Glu Val Lys Asn Tyr Phe Arg Ser Leu 
        355                 360                 365             


His Glu Gln Val Glu Val Thr Asn Arg Asn Asn Leu Phe Val Phe Pro 
    370                 375                 380                 


Val Tyr Phe Leu Ile Lys Asn Lys Thr Phe Glu Asp Tyr Lys Ser Glu 
385                 390                 395                 400 


Ile Gly Asn Phe Ser Leu Glu Ile Glu Pro Trp Phe Lys Ser Asn Ile 
                405                 410                 415     


His Arg Leu Asn Thr Tyr Ser Gln Phe Ala Asp Gln Asp Leu Ser Lys 
            420                 425                 430         


Thr Val Gln Leu Glu Glu Ile Val Leu Glu Asp Gly Ser Val Glu Glu 
        435                 440                 445             


Thr Leu Ile Thr Cys His Leu Lys His Ile Arg Asn Ser Ser Ile Gly 
    450                 455                 460                 


Val Thr Ser Lys Ile Lys Ala Ser Thr Val Gly Phe Ser Gly Thr Tyr 
465                 470                 475                 480 


Glu Lys Phe Val Glu Leu Leu Gln Ser Asp Leu Phe Ile Glu Lys Thr 
                485                 490                 495     


Ser Cys Asp Gln Thr Ile His Ala Tyr Ser Phe Leu Ser Gly Leu Met 
            500                 505                 510         


Phe Gly Gly Met Tyr Ser Phe Cys Cys Ser Lys Phe Thr Thr Pro Glu 
        515                 520                 525             


Val Leu Met Glu Ile Lys Asn Ile Lys Met Pro Ser Ile Glu Phe Leu 
    530                 535                 540                 


Glu Ser Glu Met Ser Arg Met Ser Pro Asp Val Gln Thr Val Glu Thr 
545                 550                 555                 560 


Asp Glu Arg Tyr Asp Phe Gly Leu Val Asp Asp Gly Leu Ser Asp Val 
                565                 570                 575     


Asp Leu Leu Glu Ile Asp Pro Cys Gly Asp Pro Phe Phe Thr Arg Tyr 
            580                 585                 590         


Ser Lys Leu Pro Leu Thr Asn Ser Leu Ser Phe Glu Glu Ile Ser Leu 
        595                 600                 605             


Leu Tyr Thr Thr Phe Lys Asp Ile Phe Ile Ser Arg Phe Ala Ile Leu 
    610                 615                 620                 


Gln Lys His Thr Lys Gly Lys Phe Gly Lys Thr Leu Leu Val Thr Tyr 
625                 630                 635                 640 


Asn Arg Asn Asn Val Ser Arg Lys Gln Cys Gly Glu Ile Tyr Ser His 
                645                 650                 655     


Leu Lys Ser Phe Tyr Gly Met Leu Thr Tyr Ala Ile Pro Ala Asn Asn 
            660                 665                 670         


Tyr Thr Leu Glu Gly Tyr Thr Asn Asp Asn Val Val His Leu Gly Thr 
        675                 680                 685             


Asp Lys Gln Leu Pro Gln Ile Leu Tyr Lys Lys Gly Leu Pro Arg Leu 
    690                 695                 700                 


Val Ile Lys Asp Glu Met Gly Phe Ile Ser Val Leu Asp Asn Asn Val 
705                 710                 715                 720 


Ser Lys Phe Ile Asp Val Val Asn Gly Gln Ser Phe His Leu Cys Thr 
                725                 730                 735     


Thr Val Asp Tyr Ala Thr Val Ser Lys Val Ser Met Thr Ile Thr Lys 
            740                 745                 750         


Ser Gln Gly Leu Ser Ile Gln Lys Val Ala Ile Asp Phe Gly Ser Asp 
        755                 760                 765             


Pro Lys Asn Leu Lys Leu Ser Ser Ile Tyr Val Gly Met Ser Arg Val 
    770                 775                 780                 


Thr Asp Pro Asn Asn Leu Ile Met Asn Val Asn Pro Leu Arg Leu Asn 
785                 790                 795                 800 


Tyr Glu Asn Asp Asn Phe Ile Ala Pro His Ile Val Lys Ala Leu Lys 
                805                 810                 815     


Asn Glu Asn Thr Met Leu Ile Phe 
            820                 


<210>  47
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile Tyr Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Thr Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Val Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Ile Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Ser Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  48
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro Arg Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val His Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Leu Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Ile Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  49
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ser Asp Gln Asp His Ser Met Asp Glu Met Thr Ala Val Val Lys 
1               5                   10                  15      


Ile Glu Lys Gly Val Gly Gly Asn Asn Gly Gly Asn Gly Asn Gly Gly 
            20                  25                  30          


Gly Ala Phe Ser Gln Ala Arg Ser Ser Ser Thr Gly Ser Ser Ser Ser 
        35                  40                  45              


Thr Gly Gly Gly Gly Gln Glu Ser Gln Pro Ser Pro Leu Ala Leu Leu 
    50                  55                  60                  


Ala Ala Thr Cys Ser Arg Ile Glu Ser Pro Asn Glu Asn Ser Asn Asn 
65                  70                  75                  80  


Ser Gln Gly Pro Ser Gln Ser Gly Gly Thr Gly Glu Leu Asp Leu Thr 
                85                  90                  95      


Ala Thr Gln Leu Ser Gln Gly Ala Asn Gly Trp Gln Ile Ile Ser Ser 
            100                 105                 110         


Ser Ser Gly Ala Thr Pro Thr Ser Lys Glu Gln Ser Gly Ser Ser Thr 
        115                 120                 125             


Asn Gly Ser Asn Gly Ser Glu Ser Ser Lys Asn Arg Thr Val Ser Gly 
    130                 135                 140                 


Gly Gln Tyr Val Val Ala Ala Ala Pro Asn Leu Gln Asn Gln Gln Val 
145                 150                 155                 160 


Leu Thr Gly Leu Pro Gly Val Met Pro Asn Ile Gln Tyr Gln Val Ile 
                165                 170                 175     


Pro Gln Phe Gln Thr Val Asp Gly Gln Gln Leu Gln Phe Ala Ala Thr 
            180                 185                 190         


Gly Ala Gln Val Gln Gln Asp Gly Ser Gly Gln Ile Gln Ile Ile Pro 
        195                 200                 205             


Gly Ala Asn Gln Gln Ile Ile Thr Asn Arg Gly Ser Gly Gly Asn Ile 
    210                 215                 220                 


Ile Ala Ala Met Pro Asn Leu Leu Gln Gln Ala Val Pro Leu Gln Gly 
225                 230                 235                 240 


Leu Ala Asn Asn Val Leu Ser Gly Gln Thr Gln Tyr Val Thr Asn Val 
                245                 250                 255     


Pro Val Ala Leu Asn Gly Asn Ile Thr Leu Leu Pro Val Asn Ser Val 
            260                 265                 270         


Ser Ala Ala Thr Leu Thr Pro Ser Ser Gln Ala Val Thr Ile Ser Ser 
        275                 280                 285             


Ser Gly Ser Gln Glu Ser Gly Ser Gln Pro Val Thr Ser Gly Thr Thr 
    290                 295                 300                 


Ile Ser Ser Ala Ser Leu Val Ser Ser Gln Ala Ser Ser Ser Ser Phe 
305                 310                 315                 320 


Phe Thr Asn Ala Asn Ser Tyr Ser Thr Thr Thr Thr Thr Ser Asn Met 
                325                 330                 335     


Gly Ile Met Asn Phe Thr Thr Ser Gly Ser Ser Gly Thr Asn Ser Gln 
            340                 345                 350         


Gly Gln Thr Pro Gln Arg Val Ser Gly Leu Gln Gly Ser Asp Ala Leu 
        355                 360                 365             


Asn Ile Gln Gln Asn Gln Thr Ser Gly Gly Ser Leu Gln Ala Gly Gln 
    370                 375                 380                 


Gln Lys Glu Gly Glu Gln Asn Gln Gln Thr Gln Gln Gln Gln Ile Leu 
385                 390                 395                 400 


Ile Gln Pro Gln Leu Val Gln Gly Gly Gln Ala Leu Gln Ala Leu Gln 
                405                 410                 415     


Ala Ala Pro Leu Ser Gly Gln Thr Phe Thr Thr Gln Ala Ile Ser Gln 
            420                 425                 430         


Glu Thr Leu Gln Asn Leu Gln Leu Gln Ala Val Pro Asn Ser Gly Pro 
        435                 440                 445             


Ile Ile Ile Arg Thr Pro Thr Val Gly Pro Asn Gly Gln Val Ser Trp 
    450                 455                 460                 


Gln Thr Leu Gln Leu Gln Asn Leu Gln Val Gln Asn Pro Gln Ala Gln 
465                 470                 475                 480 


Thr Ile Thr Leu Ala Pro Met Gln Gly Val Ser Leu Gly Gln Thr Ser 
                485                 490                 495     


Ser Ser Asn Thr Thr Leu Thr Pro Ile Ala Ser Ala Ala Ser Ile Pro 
            500                 505                 510         


Ala Gly Thr Val Thr Val Asn Ala Ala Gln Leu Ser Ser Met Pro Gly 
        515                 520                 525             


Leu Gln Thr Ile Asn Leu Ser Ala Leu Gly Thr Ser Gly Ile Gln Val 
    530                 535                 540                 


His Pro Ile Gln Gly Leu Pro Leu Ala Ile Ala Asn Ala Pro Gly Asp 
545                 550                 555                 560 


His Gly Ala Gln Leu Gly Leu His Gly Ala Gly Gly Asp Gly Ile His 
                565                 570                 575     


Asp Asp Thr Ala Gly Gly Glu Glu Gly Glu Asn Ser Pro Asp Ala Gln 
            580                 585                 590         


Pro Gln Ala Gly Arg Arg Thr Arg Arg Glu Ala Cys Thr Cys Pro Tyr 
        595                 600                 605             


Cys Lys Asp Ser Glu Gly Arg Gly Ser Gly Asp Pro Gly Lys Lys Lys 
    610                 615                 620                 


Gln His Ile Cys His Ile Gln Gly Cys Gly Lys Val Tyr Gly Lys Thr 
625                 630                 635                 640 


Ser His Leu Arg Ala His Leu Arg Trp His Thr Gly Glu Arg Pro Phe 
                645                 650                 655     


Met Cys Thr Trp Ser Tyr Cys Gly Lys Arg Phe Thr Arg Ser Asp Glu 
            660                 665                 670         


Leu Gln Arg His Lys Arg Thr His Thr Gly Glu Lys Lys Phe Ala Cys 
        675                 680                 685             


Pro Glu Cys Pro Lys Arg Phe Met Arg Ser Asp His Leu Ser Lys His 
    690                 695                 700                 


Ile Lys Thr His Gln Asn Lys Lys Gly Gly Pro Gly Val Ala Leu Ser 
705                 710                 715                 720 


Val Gly Thr Leu Pro Leu Asp Ser Gly Ala Gly Ser Glu Gly Ser Gly 
                725                 730                 735     


Thr Ala Thr Pro Ser Ala Leu Ile Thr Thr Asn Met Val Ala Met Glu 
            740                 745                 750         


Ala Ile Cys Pro Glu Gly Ile Ala Arg Leu Ala Asn Ser Gly Ile Asn 
        755                 760                 765             


Val Met Gln Val Ala Asp Leu Gln Ser Ile Asn Ile Ser Gly Asn Gly 
    770                 775                 780                 


Phe 
785 


<210>  50
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
    210                 215                 220                 


Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                245                 250                 255     


Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
            260                 265                 270         


Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
        275                 280                 285             


Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
    290                 295                 300                 


Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
305                 310                 315                 320 


Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                325                 330     


<210>  51
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Asp Leu Pro Val Gly Pro Gly Ala Ala Gly Pro Ser Asn Val Pro 
1               5                   10                  15      


Ala Phe Leu Thr Lys Leu Trp Thr Leu Val Ser Asp Pro Asp Thr Asp 
            20                  25                  30          


Ala Leu Ile Cys Trp Ser Pro Ser Gly Asn Ser Phe His Val Phe Asp 
        35                  40                  45              


Gln Gly Gln Phe Ala Lys Glu Val Leu Pro Lys Tyr Phe Lys His Asn 
    50                  55                  60                  


Asn Met Ala Ser Phe Val Arg Gln Leu Asn Met Tyr Gly Phe Arg Lys 
65                  70                  75                  80  


Val Val His Ile Glu Gln Gly Gly Leu Val Lys Pro Glu Arg Asp Asp 
                85                  90                  95      


Thr Glu Phe Gln His Pro Cys Phe Leu Arg Gly Gln Glu Gln Leu Leu 
            100                 105                 110         


Glu Asn Ile Lys Arg Lys Val Thr Ser Val Ser Thr Leu Lys Ser Glu 
        115                 120                 125             


Asp Ile Lys Ile Arg Gln Asp Ser Val Thr Lys Leu Leu Thr Asp Val 
    130                 135                 140                 


Gln Leu Met Lys Gly Lys Gln Glu Cys Met Asp Ser Lys Leu Leu Ala 
145                 150                 155                 160 


Met Lys His Glu Asn Glu Ala Leu Trp Arg Glu Val Ala Ser Leu Arg 
                165                 170                 175     


Gln Lys His Ala Gln Gln Gln Lys Val Val Asn Lys Leu Ile Gln Phe 
            180                 185                 190         


Leu Ile Ser Leu Val Gln Ser Asn Arg Ile Leu Gly Val Lys Arg Lys 
        195                 200                 205             


Ile Pro Leu Met Leu Asn Asp Ser Gly Ser Ala His Ser Met Pro Lys 
    210                 215                 220                 


Tyr Ser Arg Gln Phe Ser Leu Glu His Val His Gly Ser Gly Pro Tyr 
225                 230                 235                 240 


Ser Ala Pro Ser Pro Ala Tyr Ser Ser Ser Ser Leu Tyr Ala Pro Asp 
                245                 250                 255     


Ala Val Ala Ser Ser Gly Pro Ile Ile Ser Asp Ile Thr Glu Leu Ala 
            260                 265                 270         


Pro Ala Ser Pro Met Ala Ser Pro Gly Gly Ser Ile Asp Glu Arg Pro 
        275                 280                 285             


Leu Ser Ser Ser Pro Leu Val Arg Val Lys Glu Glu Pro Pro Ser Pro 
    290                 295                 300                 


Pro Gln Ser Pro Arg Val Glu Glu Ala Ser Pro Gly Arg Pro Ser Ser 
305                 310                 315                 320 


Val Asp Thr Leu Leu Ser Pro Thr Ala Leu Ile Asp Ser Ile Leu Arg 
                325                 330                 335     


Glu Ser Glu Pro Ala Pro Ala Ser Val Thr Ala Leu Thr Asp Ala Arg 
            340                 345                 350         


Gly His Thr Asp Thr Glu Gly Arg Pro Pro Ser Pro Pro Pro Thr Ser 
        355                 360                 365             


Thr Pro Glu Lys Cys Leu Ser Val Ala Cys Leu Asp Lys Asn Glu Leu 
    370                 375                 380                 


Ser Asp His Leu Asp Ala Met Asp Ser Asn Leu Asp Asn Leu Gln Thr 
385                 390                 395                 400 


Met Leu Ser Ser His Gly Phe Ser Val Asp Thr Ser Ala Leu Leu Asp 
                405                 410                 415     


Leu Phe Ser Pro Ser Val Thr Val Pro Asp Met Ser Leu Pro Asp Leu 
            420                 425                 430         


Asp Ser Ser Leu Ala Ser Ile Gln Glu Leu Leu Ser Pro Gln Glu Pro 
        435                 440                 445             


Pro Arg Pro Pro Glu Ala Glu Asn Ser Ser Pro Asp Ser Gly Lys Gln 
    450                 455                 460                 


Leu Val His Tyr Thr Ala Gln Pro Leu Phe Leu Leu Asp Pro Gly Ser 
465                 470                 475                 480 


Val Asp Thr Gly Ser Asn Asp Leu Pro Val Leu Phe Glu Leu Gly Glu 
                485                 490                 495     


Gly Ser Tyr Phe Ser Glu Gly Asp Gly Phe Ala Glu Asp Pro Thr Ile 
            500                 505                 510         


Ser Leu Leu Thr Gly Ser Glu Pro Pro Lys Ala Lys Asp Pro Thr Val 
        515                 520                 525             


Ser 
    


<210>  52
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gln Arg Leu Val Ala Trp Asp Pro Ala Cys Leu Pro Leu Pro Pro 
1               5                   10                  15      


Pro Pro Pro Ala Phe Lys Ser Met Glu Val Ala Asn Phe Tyr Tyr Glu 
            20                  25                  30          


Ala Asp Cys Leu Ala Ala Ala Tyr Gly Gly Lys Ala Ala Pro Ala Ala 
        35                  40                  45              


Pro Pro Ala Ala Arg Pro Gly Pro Arg Pro Pro Ala Gly Glu Leu Gly 
    50                  55                  60                  


Ser Ile Gly Asp His Glu Arg Ala Ile Asp Phe Ser Pro Tyr Leu Glu 
65                  70                  75                  80  


Pro Leu Gly Ala Pro Gln Ala Pro Ala Pro Ala Thr Ala Thr Asp Thr 
                85                  90                  95      


Phe Glu Ala Ala Pro Pro Ala Pro Ala Pro Ala Pro Ala Ser Ser Gly 
            100                 105                 110         


Gln His His Asp Phe Leu Ser Asp Leu Phe Ser Asp Asp Tyr Gly Gly 
        115                 120                 125             


Lys Asn Cys Lys Lys Pro Ala Glu Tyr Gly Tyr Val Ser Leu Gly Arg 
    130                 135                 140                 


Leu Gly Ala Ala Lys Gly Ala Leu His Pro Gly Cys Phe Ala Pro Leu 
145                 150                 155                 160 


His Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Leu Lys Ala Glu 
                165                 170                 175     


Pro Gly Phe Glu Pro Ala Asp Cys Lys Arg Lys Glu Glu Ala Gly Ala 
            180                 185                 190         


Pro Gly Gly Gly Ala Gly Met Ala Ala Gly Phe Pro Tyr Ala Leu Arg 
        195                 200                 205             


Ala Tyr Leu Gly Tyr Gln Ala Val Pro Ser Gly Ser Ser Gly Ser Leu 
    210                 215                 220                 


Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro Ala Asp 
225                 230                 235                 240 


Ala Lys Ala Pro Pro Thr Ala Cys Tyr Ala Gly Ala Ala Pro Ala Pro 
                245                 250                 255     


Ser Gln Val Lys Ser Lys Ala Lys Lys Thr Val Asp Lys His Ser Asp 
            260                 265                 270         


Glu Tyr Lys Ile Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
        275                 280                 285             


Arg Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu 
    290                 295                 300                 


Glu Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu 
305                 310                 315                 320 


Ser Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu 
                325                 330                 335     


Pro Leu Leu Ala Ser Ser Gly His Cys 
            340                 345 


<210>  53
<211>  743
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Asn Asn Pro Ser Glu Thr Ser Lys Pro Ser Met Glu Ser Gly Asp 
1               5                   10                  15      


Gly Asn Thr Gly Thr Gln Thr Asn Gly Leu Asp Phe Gln Lys Gln Pro 
            20                  25                  30          


Val Pro Val Gly Gly Ala Ile Ser Thr Ala Gln Ala Gln Ala Phe Leu 
        35                  40                  45              


Gly His Leu His Gln Val Gln Leu Ala Gly Thr Ser Leu Gln Ala Ala 
    50                  55                  60                  


Ala Gln Ser Leu Asn Val Gln Ser Lys Ser Asn Glu Glu Ser Gly Asp 
65                  70                  75                  80  


Ser Gln Gln Pro Ser Gln Pro Ser Gln Gln Pro Ser Val Gln Ala Ala 
                85                  90                  95      


Ile Pro Gln Thr Gln Leu Met Leu Ala Gly Gly Gln Ile Thr Gly Leu 
            100                 105                 110         


Thr Leu Thr Pro Ala Gln Gln Gln Leu Leu Leu Gln Gln Ala Gln Ala 
        115                 120                 125             


Gln Ala Gln Leu Leu Ala Ala Ala Val Gln Gln His Ser Ala Ser Gln 
    130                 135                 140                 


Gln His Ser Ala Ala Gly Ala Thr Ile Ser Ala Ser Ala Ala Thr Pro 
145                 150                 155                 160 


Met Thr Gln Ile Pro Leu Ser Gln Pro Ile Gln Ile Ala Gln Asp Leu 
                165                 170                 175     


Gln Gln Leu Gln Gln Leu Gln Gln Gln Asn Leu Asn Leu Gln Gln Phe 
            180                 185                 190         


Val Leu Val His Pro Thr Thr Asn Leu Gln Pro Ala Gln Phe Ile Ile 
        195                 200                 205             


Ser Gln Thr Pro Gln Gly Gln Gln Gly Leu Leu Gln Ala Gln Asn Leu 
    210                 215                 220                 


Leu Thr Gln Leu Pro Gln Gln Ser Gln Ala Asn Leu Leu Gln Ser Gln 
225                 230                 235                 240 


Pro Ser Ile Thr Leu Thr Ser Gln Pro Ala Thr Pro Thr Arg Thr Ile 
                245                 250                 255     


Ala Ala Thr Pro Ile Gln Thr Leu Pro Gln Ser Gln Ser Thr Pro Lys 
            260                 265                 270         


Arg Ile Asp Thr Pro Ser Leu Glu Glu Pro Ser Asp Leu Glu Glu Leu 
        275                 280                 285             


Glu Gln Phe Ala Lys Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe 
    290                 295                 300                 


Thr Gln Gly Asp Val Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp 
305                 310                 315                 320 


Phe Ser Gln Thr Thr Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe 
                325                 330                 335     


Lys Asn Met Cys Lys Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp 
            340                 345                 350         


Ala Glu Asn Leu Ser Ser Asp Ser Ser Leu Ser Ser Pro Ser Ala Leu 
        355                 360                 365             


Asn Ser Pro Gly Ile Glu Gly Leu Ser Arg Arg Arg Lys Lys Arg Thr 
    370                 375                 380                 


Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu 
385                 390                 395                 400 


Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu 
                405                 410                 415     


Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln 
            420                 425                 430         


Lys Glu Lys Arg Ile Asn Pro Pro Ser Ser Gly Gly Thr Ser Ser Ser 
        435                 440                 445             


Pro Ile Lys Ala Ile Phe Pro Ser Pro Thr Ser Leu Val Ala Thr Thr 
    450                 455                 460                 


Pro Ser Leu Val Thr Ser Ser Ala Ala Thr Thr Leu Thr Val Ser Pro 
465                 470                 475                 480 


Val Leu Pro Leu Thr Ser Ala Ala Val Thr Asn Leu Ser Val Thr Gly 
                485                 490                 495     


Thr Ser Asp Thr Thr Ser Asn Asn Thr Ala Thr Val Ile Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala Ser Ser Ala Val Thr Ser Pro Ser Leu Ser Pro Ser Pro 
        515                 520                 525             


Ser Ala Ser Ala Ser Thr Ser Glu Ala Ser Ser Ala Ser Glu Thr Ser 
    530                 535                 540                 


Thr Thr Gln Thr Thr Ser Thr Pro Leu Ser Ser Pro Leu Gly Thr Ser 
545                 550                 555                 560 


Gln Val Met Val Thr Ala Ser Gly Leu Gln Thr Ala Ala Ala Ala Ala 
                565                 570                 575     


Leu Gln Gly Ala Ala Gln Leu Pro Ala Asn Ala Ser Leu Ala Ala Met 
            580                 585                 590         


Ala Ala Ala Ala Gly Leu Asn Pro Ser Leu Met Ala Pro Ser Gln Phe 
        595                 600                 605             


Ala Ala Gly Gly Ala Leu Leu Ser Leu Asn Pro Gly Thr Leu Ser Gly 
    610                 615                 620                 


Ala Leu Ser Pro Ala Leu Met Ser Asn Ser Thr Leu Ala Thr Ile Gln 
625                 630                 635                 640 


Ala Leu Ala Ser Gly Gly Ser Leu Pro Ile Thr Ser Leu Asp Ala Thr 
                645                 650                 655     


Gly Asn Leu Val Phe Ala Asn Ala Gly Gly Ala Pro Asn Ile Val Thr 
            660                 665                 670         


Ala Pro Leu Phe Leu Asn Pro Gln Asn Leu Ser Leu Leu Thr Ser Asn 
        675                 680                 685             


Pro Val Ser Leu Val Ser Ala Ala Ala Ala Ser Ala Gly Asn Ser Ala 
    690                 695                 700                 


Pro Val Ala Ser Leu His Ala Thr Ser Thr Ser Ala Glu Ser Ile Gln 
705                 710                 715                 720 


Asn Ser Leu Phe Thr Val Ala Ser Ala Ser Gly Ala Ala Ser Thr Thr 
                725                 730                 735     


Thr Thr Ala Ser Lys Ala Gln 
            740             


<210>  54
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Gly Pro Phe Ser Val Lys Ser Ser Pro Gly Leu Gly Pro Val 
        115                 120                 125             


Glu Leu Ala Ala Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser 
    130                 135                 140                 


Leu Met Leu Met Val Tyr Ile Cys His Asn Arg Thr Val Ile His His 
145                 150                 155                 160 


Arg Val Pro Asn Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser 
                165                 170                 175     


Glu Gly Thr Thr Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly 
            180                 185                 190         


Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr 
        195                 200                 205             


Ile Val Leu Gln Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp 
    210                 215                 220                 


Arg Gly Lys Trp Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser 
225                 230                 235                 240 


Arg Glu Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val 
                245                 250                 255     


Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys 
            260                 265                 270         


Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu 
        275                 280                 285             


His Gly Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu 
    290                 295                 300                 


Gly Met Ile Lys Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu 
305                 310                 315                 320 


His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg 
                325                 330                 335     


Asp Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys 
            340                 345                 350         


Ile Ala Asp Leu Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr 
        355                 360                 365             


Ile Asp Ile Ala Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala 
    370                 375                 380                 


Pro Glu Val Leu Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe 
385                 390                 395                 400 


Lys Arg Ala Asp Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala 
                405                 410                 415     


Arg Arg Cys Ser Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr 
            420                 425                 430         


Tyr Asp Leu Val Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val 
        435                 440                 445             


Val Cys Glu Gln Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser 
    450                 455                 460                 


Cys Glu Ala Leu Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr 
465                 470                 475                 480 


Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu 
                485                 490                 495     


Ser Gln Leu Ser Gln Gln Glu Gly Ile Lys Met 
            500                 505         


<210>  55
<211>  1106
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210>  56
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Lys Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  57
<211>  1338
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Ser Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Phe Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile  Ser Tyr Ser Phe Gln  Val Ala Arg 
        995                 1000                 1005             


Gly Met  Glu Phe Leu Ser Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1010                 1015                 1020             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Asn Asn Val  Val Lys Ile 
    1025                 1030                 1035             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asn  Pro Asp Tyr 
    1040                 1045                 1050             


Val Arg  Lys Gly Asp Thr Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1055                 1060                 1065             


Glu Ser  Ile Phe Asp Lys Ile  Tyr Ser Thr Lys Ser  Asp Val Trp 
    1070                 1075                 1080             


Ser Tyr  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Gly Ser 
    1085                 1090                 1095             


Pro Tyr  Pro Gly Val Gln Met  Asp Glu Asp Phe Cys  Ser Arg Leu 
    1100                 1105                 1110             


Arg Glu  Gly Met Arg Met Arg  Ala Pro Glu Tyr Ser  Thr Pro Glu 
    1115                 1120                 1125             


Ile Tyr  Gln Ile Met Leu Asp  Cys Trp His Arg Asp  Pro Lys Glu 
    1130                 1135                 1140             


Arg Pro  Arg Phe Ala Glu Leu  Val Glu Lys Leu Gly  Asp Leu Leu 
    1145                 1150                 1155             


Gln Ala  Asn Val Gln Gln Asp  Gly Lys Asp Tyr Ile  Pro Ile Asn 
    1160                 1165                 1170             


Ala Ile  Leu Thr Gly Asn Ser  Gly Phe Thr Tyr Ser  Thr Pro Ala 
    1175                 1180                 1185             


Phe Ser  Glu Asp Phe Phe Lys  Glu Ser Ile Ser Ala  Pro Lys Phe 
    1190                 1195                 1200             


Asn Ser  Gly Ser Ser Asp Asp  Val Arg Tyr Val Asn  Ala Phe Lys 
    1205                 1210                 1215             


Phe Met  Ser Leu Glu Arg Ile  Lys Thr Phe Glu Glu  Leu Leu Pro 
    1220                 1225                 1230             


Asn Ala  Thr Ser Met Phe Asp  Asp Tyr Gln Gly Asp  Ser Ser Thr 
    1235                 1240                 1245             


Leu Leu  Ala Ser Pro Met Leu  Lys Arg Phe Thr Trp  Thr Asp Ser 
    1250                 1255                 1260             


Lys Pro  Lys Ala Ser Leu Lys  Ile Asp Leu Arg Val  Thr Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Ser Gly Leu Ser  Asp Val Ser Arg Pro  Ser Phe Cys 
    1280                 1285                 1290             


His Ser  Ser Cys Gly His Val  Ser Glu Gly Lys Arg  Arg Phe Thr 
    1295                 1300                 1305             


Tyr Asp  His Ala Glu Leu Glu  Arg Lys Ile Ala Cys  Cys Ser Pro 
    1310                 1315                 1320             


Pro Pro  Asp Tyr Asn Ser Val  Val Leu Tyr Ser Thr  Pro Pro Ile 
    1325                 1330                 1335             


<210>  58
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210>  59
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly His Leu Tyr Thr Val 
1               5                   10                  15      


Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met 
            20                  25                  30          


Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys Glu 
        35                  40                  45              


Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val Val 
    50                  55                  60                  


Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr His Ser 
65                  70                  75                  80  


Phe His Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe Thr Val Thr Lys 
                85                  90                  95      


Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met Ala 
            100                 105                 110         


Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile Trp 
        115                 120                 125             


Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys Thr 
    130                 135                 140                 


Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu Phe 
145                 150                 155                 160 


Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln Lys 
                165                 170                 175     


Glu Ile 
        


<210>  60
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Gly Asn Arg Gly Met Glu Glu Leu Ile Pro Leu Val Asn Lys Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ser Ile Gly Gln Ser Cys His Leu Asp Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Ile Leu Gln Leu Ile Phe Ser Lys Thr Glu His 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Ser Lys Lys Phe Thr Asp Phe Asp Glu 
                85                  90                  95      


Val Arg Gln Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn 
            100                 105                 110         


Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Arg Val Lys Asp Met Ile 
145                 150                 155                 160 


Leu Gln Phe Ile Ser Arg Glu Ser Ser Leu Ile Leu Ala Val Thr Pro 
                165                 170                 175     


Ala Asn Met Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Glu Gly Lys Lys Asp Ile Arg Ala Ala Leu Ala Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Met Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro His Leu Gln Lys Thr Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Glu Ser Leu Pro Ala Leu Arg Ser Lys Leu Gln Ser Gln Leu 
    290                 295                 300                 


Leu Ser Leu Glu Lys Glu Val Glu Glu Tyr Lys Ile Phe Arg Pro Asp 
305                 310                 315                 320 


Asp Pro Thr Pro Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Gly Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp 
            340                 345                 350         


Thr Leu Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Asp Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Val Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Leu Ala Phe Glu Ala Ile Val Lys Lys Gln 
                405                 410                 415     


Val Val Lys Leu Lys Glu Pro Cys Leu Lys Cys Val Asp Leu Val Ile 
            420                 425                 430         


Gln Glu Leu Ile Asn Thr Val Arg Gln Cys Thr Ser Lys Leu Ser Ser 
        435                 440                 445             


Tyr Pro Arg Leu Arg Glu Glu Thr Glu Arg Ile Val Thr Thr Tyr Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Arg Thr Lys Asp Gln Ile Leu Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Glu Gln Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Thr Gln Leu Asn Lys Lys Arg Ala Ile 
            500                 505                 510         


Pro Asn Gln Val Ile Arg Arg Gly Trp Leu Thr Ile Asn Asn Ile Ser 
        515                 520                 525             


Leu Met Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val Leu Thr Ala Glu 
    530                 535                 540                 


Ser Leu Ser Trp Tyr Lys Asp Glu Glu Glu Lys Glu Lys Lys Tyr Met 
545                 550                 555                 560 


Leu Pro Leu Asp Asn Leu Lys Ile Arg Asp Val Glu Lys Gly Phe Met 
                565                 570                 575     


Ser Asn Lys His Val Phe Ala Ile Phe Asn Thr Glu Gln Arg Asn Val 
            580                 585                 590         


Tyr Lys Asp Leu Arg Gln Ile Glu Leu Ala Cys Asp Ser Gln Glu Asp 
        595                 600                 605             


Val Asp Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly Val Tyr Pro Glu 
    610                 615                 620                 


Lys Asp Gln Ala Glu Asn Glu Asp Gly Ala Gln Glu Asn Thr Phe Ser 
625                 630                 635                 640 


Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile Arg Asn Leu Val 
                645                 650                 655     


Asp Ser Tyr Val Ala Ile Ile Asn Lys Ser Ile Arg Asp Leu Met Pro 
            660                 665                 670         


Lys Thr Ile Met His Leu Met Ile Asn Asn Thr Lys Ala Phe Ile His 
        675                 680                 685             


His Glu Leu Leu Ala Tyr Leu Tyr Ser Ser Ala Asp Gln Ser Ser Leu 
    690                 695                 700                 


Met Glu Glu Ser Ala Asp Gln Ala Gln Arg Arg Asp Asp Met Leu Arg 
705                 710                 715                 720 


Met Tyr His Ala Leu Lys Glu Ala Leu Asn Ile Ile Gly Asp Ile Ser 
                725                 730                 735     


Thr Ser Thr Val Ser Thr Pro Val Pro Pro Pro Val Asp Asp Thr Trp 
            740                 745                 750         


Leu Gln Ser Ala Ser Ser His Ser Pro Thr Pro Gln Arg Arg Pro Val 
        755                 760                 765             


Ser Ser Ile His Pro Pro Gly Arg Pro Pro Ala Val Arg Gly Pro Thr 
    770                 775                 780                 


Pro Gly Pro Pro Leu Ile Pro Val Pro Val Gly Ala Ala Ala Ser Phe 
785                 790                 795                 800 


Ser Ala Pro Pro Ile Pro Ser Arg Pro Gly Pro Gln Ser Val Phe Ala 
                805                 810                 815     


Asn Ser Asp Leu Phe Pro Ala Pro Pro Gln Ile Pro Ser Arg Pro Val 
            820                 825                 830         


Arg Ile Pro Pro Gly Ile Pro Pro Gly Val Pro Ser Arg Arg Pro Pro 
        835                 840                 845             


Ala Ala Pro Ser Arg Pro Thr Ile Ile Arg Pro Ala Glu Pro Ser Leu 
    850                 855                 860                 


Leu Asp 
865     


<210>  61
<211>  1675
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val Thr Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro Pro Thr Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Thr Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Thr Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Thr Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Thr Met Met Asn  His Pro Thr 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Thr 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Thr Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Thr Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Thr  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Thr 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu 
    1610                 1615                 1620             


Glu Gln  Ala Thr Glu Thr Gln  Pro Ile Val Tyr Gly  Gln Pro Gln 
    1625                 1630                 1635             


Leu Met  Leu Thr Ala Gly Pro  Ser Val Ala Val Pro  Pro Gln Ala 
    1640                 1645                 1650             


Pro Phe  Gly Tyr Gly Tyr Thr  Ala Pro Pro Tyr Gly  Gln Pro Gln 
    1655                 1660                 1665             


Pro Gly  Phe Gly Tyr Ser Met  
    1670                 1675 


<210>  62
<211>  1640
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Gln Ile Leu Pro Val Arg Phe Gln Glu His Phe Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Thr Ile Ile Asp Met Ser Asp Pro Met Ala Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Glu Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Ala Glu Glu Val Ile Phe Trp Lys 
            100                 105                 110         


Trp Val Ser Val Asn Thr Val Ala Leu Val Thr Glu Thr Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Asp Ser Gln Pro Met Lys Met Phe Asp Arg 
    130                 135                 140                 


His Thr Ser Leu Val Gly Cys Gln Val Ile His Tyr Arg Thr Asp Glu 
145                 150                 155                 160 


Tyr Gln Lys Trp Leu Leu Leu Val Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ala Phe Ala Glu Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Lys Pro Ala Thr Leu Phe Cys Phe Ala Val Arg Asn Pro Thr 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Gln Pro Ala Ala Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Val Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Gly Ala Lys His Gly Val 
            260                 265                 270         


Ile Tyr Leu Ile Thr Lys Tyr Gly Tyr Leu His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Ser Gly Val Cys Ile Cys Met Asn Arg Ile Ser Ala Asp Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Lys Pro Thr Ser Gly Ile Ile Gly Val Asn Lys 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Asp Asn Ile Val Asn 
                325                 330                 335     


Tyr Ala Thr Asn Val Leu Gln Asn Pro Asp Leu Gly Leu Arg Leu Ala 
            340                 345                 350         


Val Arg Ser Asn Leu Ala Gly Ala Glu Lys Leu Phe Val Arg Lys Phe 
        355                 360                 365             


Asn Thr Leu Phe Ala Gln Gly Ser Tyr Ala Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Ser Ala Pro Lys Gly Ile Leu Arg Thr Arg Glu Thr Val Gln Lys 
385                 390                 395                 400 


Phe Gln Ser Ile Pro Ala Gln Ser Gly Gln Ala Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Leu Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys His Leu Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Thr Thr Asp Pro Met Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Ser Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Phe Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Gly Val Met Lys Ile Ser Pro Glu Gln 
        515                 520                 525             


Gly Leu Gln Phe Ser Arg Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asn Ile Ser Gln Ile Val Asp Ile Phe Met Glu Asn Ser Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ser Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ala 
                565                 570                 575     


Glu Gly Leu Leu Gln Thr Trp Leu Leu Glu Met Asn Leu Val His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Lys Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Gln Ala Leu Glu His Tyr Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Phe Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Val Glu Cys Leu His Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Leu Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Gly Thr Gln Ala Leu Val Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Tyr Lys Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Leu Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Ser 
            740                 745                 750         


Cys Tyr Asn Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Gly Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Arg Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Thr Pro Ala Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Glu Val Ile Lys His Leu 
            820                 825                 830         


Ile Met Ala Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ser 
    850                 855                 860                 


Gln Ile Gln Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Ser Pro Glu Cys Phe Leu Arg Glu 
                885                 890                 895     


Asn Ala Tyr Tyr Asp Ser Ser Val Val Gly Arg Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Lys Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Glu Ala 
    930                 935                 940                 


Arg Tyr Leu Val Cys Arg Lys Asp Pro Glu Leu Trp Ala His Val Leu 
945                 950                 955                 960 


Glu Glu Thr Asn Pro Ser Arg Arg Gln Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Arg Asp Pro Glu Glu Ile Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Ser  Arg Leu Asp Asn Tyr  Asp Ala Leu 
    1040                 1045                 1050             


Asp Ile  Ala Ser Ile Ala Val  Ser Ser Ala Leu Tyr  Glu Glu Ala 
    1055                 1060                 1065             


Phe Thr  Val Phe His Lys Phe  Asp Met Asn Ala Ser  Ala Ile Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Gln 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Asp Leu  Val Lys Glu Ala Ile  Asn Ser Tyr 
    1115                 1120                 1125             


Ile Arg  Gly Asp Asp Pro Ser  Ser Tyr Leu Glu Val  Val Gln Ser 
    1130                 1135                 1140             


Ala Ser  Arg Ser Asn Asn Trp  Glu Asp Leu Val Lys  Phe Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Gly Arg  Glu Ser Tyr Ile Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Ser Arg Val Ser Glu  Leu Glu Asp 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Glu Glu Gly Met  Tyr Glu Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Ser Asn  Val Ser Asn Phe Ala  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Asn Ser Arg  Lys Ala Ser 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Met Asp Gly 
    1250                 1255                 1260             


Gln Glu  Phe Arg Phe Ala Gln  Leu Cys Gly Leu His  Ile Val Ile 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Met Cys Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Leu Leu Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Leu Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Val  Leu Thr Met Met Ser  His Pro Thr 
    1370                 1375                 1380             


Glu Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Cys Tyr  Arg Ala Leu Gln Phe  Tyr Leu Asp 
    1400                 1405                 1410             


Tyr Lys  Pro Leu Leu Ile Asn  Asp Leu Leu Leu Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Trp Thr  Val Ser Phe Phe Ser  Lys Ala Gly 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Ser His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ala Leu Asn His Leu  Leu Thr Glu 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Gly Leu  Arg Ala Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Gln Leu Glu  Lys His Gln 
    1490                 1495                 1500             


Leu Met  Glu Phe Arg Cys Ile  Ala Ala Tyr Leu Tyr  Lys Gly Asn 
    1505                 1510                 1515             


Asn Trp  Trp Ala Gln Ser Val  Glu Leu Cys Lys Lys  Asp His Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln His  Ala Ala Glu Ser Arg  Asp Ala Glu 
    1535                 1540                 1545             


Leu Ala  Gln Lys Leu Leu Gln  Trp Phe Leu Glu Glu  Gly Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Ala Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Met Val Leu Glu Leu  Ala Trp Arg His Asn  Leu Val Asp 
    1580                 1585                 1590             


Leu Ala  Met Pro Tyr Phe Ile  Gln Val Met Arg Glu  Tyr Leu Ser 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Leu Glu Ser Leu Arg  Lys Gln Glu 
    1610                 1615                 1620             


Glu His  Val Thr Glu Pro Ala  Pro Leu Val Phe Asp  Phe Asp Gly 
    1625                 1630                 1635             


His Glu  
    1640 


<210>  63
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
65                  70                  75                  80  


Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Thr Asp Ser Tyr Ala Ala 
                85                  90                  95      


Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
            100                 105                 110         


Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
        115                 120                 125             


Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
    130                 135                 140                 


Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Thr Lys Ala Asn 
145                 150                 155                 160 


Asn Arg Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser 
                165                 170                 175     


Pro Gly Thr Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro 
            180                 185                 190         


Lys Ser Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu 
        195                 200                 205             


Ile Ser Leu Lys Gln Ala Pro Leu Val His 
    210                 215             


<210>  64
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Asp Asp Phe Gly Phe Phe Ser Ser Ser Glu Ser Gly Ala Pro 
1               5                   10                  15      


Glu Ala Ala Glu Glu Asp Pro Ala Ala Ala Phe Leu Ala Gln Gln Glu 
            20                  25                  30          


Ser Glu Ile Ala Gly Ile Glu Asn Asp Glu Gly Phe Gly Ala Pro Ala 
        35                  40                  45              


Gly Ser His Ala Ala Pro Ala Gln Pro Gly Pro Thr Ser Gly Ala Gly 
    50                  55                  60                  


Ser Glu Asp Met Gly Thr Thr Val Asn Gly Asp Val Phe Gln Glu Ala 
65                  70                  75                  80  


Asn Gly Pro Ala Asp Gly Tyr Ala Ala Ile Ala Gln Ala Asp Arg Leu 
                85                  90                  95      


Thr Gln Glu Pro Glu Ser Ile Arg Lys Trp Arg Glu Glu Gln Arg Lys 
            100                 105                 110         


Arg Leu Gln Glu Leu Asp Ala Ala Ser Lys Val Thr Glu Gln Glu Trp 
        115                 120                 125             


Arg Glu Lys Ala Lys Lys Asp Leu Glu Glu Trp Asn Gln Arg Gln Ser 
    130                 135                 140                 


Glu Gln Val Glu Lys Asn Lys Ile Asn Asn Arg Ala Ser Glu Glu Ala 
145                 150                 155                 160 


Phe Val Lys Glu Ser Lys Glu Glu Thr Pro Gly Thr Glu Trp Glu Lys 
                165                 170                 175     


Val Ala Gln Leu Cys Asp Phe Asn Pro Lys Ser Ser Lys Gln Cys Lys 
            180                 185                 190         


Asp Val Ser Arg Leu Arg Ser Val Leu Met Ser Leu Lys Gln Thr Pro 
        195                 200                 205             


Leu Ser Arg 
    210     


<210>  65
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ser Gln Thr Ala Met Ser Glu Thr Tyr Asp Phe Leu Phe Lys Phe 
1               5                   10                  15      


Leu Val Ile Gly Asn Ala Gly Thr Gly Lys Ser Cys Leu Leu His Gln 
            20                  25                  30          


Phe Ile Glu Lys Lys Phe Lys Asp Asp Ser Asn His Thr Ile Gly Val 
        35                  40                  45              


Glu Phe Gly Ser Lys Ile Ile Asn Val Gly Gly Lys Tyr Val Lys Leu 
    50                  55                  60                  


Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Val Thr Arg 
65                  70                  75                  80  


Ser Tyr Tyr Arg Gly Ala Ala Gly Ala Leu Leu Val Tyr Asp Ile Thr 
                85                  90                  95      


Ser Arg Glu Thr Tyr Asn Ala Leu Thr Asn Trp Leu Thr Asp Ala Arg 
            100                 105                 110         


Met Leu Ala Ser Gln Asn Ile Val Ile Ile Leu Cys Gly Asn Lys Lys 
        115                 120                 125             


Asp Leu Asp Ala Asp Arg Glu Val Thr Phe Leu Glu Ala Ser Arg Phe 
    130                 135                 140                 


Ala Gln Glu Asn Glu Leu Met Phe Leu Glu Thr Ser Ala Leu Thr Gly 
145                 150                 155                 160 


Glu Asn Val Glu Glu Ala Phe Val Gln Cys Ala Arg Lys Ile Leu Asn 
                165                 170                 175     


Lys Ile Glu Ser Gly Glu Leu Asp Pro Glu Arg Met Gly Ser Gly Ile 
            180                 185                 190         


Gln Tyr Gly Asp Ala Ala Leu Arg Gln Leu Arg Ser Pro Arg Arg Ala 
        195                 200                 205             


Gln Ala Pro Asn Ala Gln Glu Cys Gly Cys 
    210                 215             


<210>  66
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15      


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30          


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95      


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110         


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125             


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140                 


Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160 


Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175     


Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
            180                 185                 190         


Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
        195                 200                 205             


Lys Val Gln Cys Cys Gln Asn Ile 
    210                 215     


<210>  67
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Asn Arg Cys Trp Ala Leu Phe Leu Ser Leu Cys Cys Tyr Leu Arg 
1               5                   10                  15      


Leu Val Ser Ala Glu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu Met 
            20                  25                  30          


Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn Met 
    50                  55                  60                  


Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly Arg 
65                  70                  75                  80  


Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu 
                85                  90                  95      


Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp 
            100                 105                 110         


Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln 
        115                 120                 125             


Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr 
    130                 135                 140                 


Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg 
145                 150                 155                 160 


Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu 
                165                 170                 175     


Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg Ser 
            180                 185                 190         


Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg Val 
        195                 200                 205             


Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His Arg 
    210                 215                 220                 


Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu Gly 
225                 230                 235                 240 


Ala 
    


<210>  68
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                 310                 315                 320 


Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                 330                 335     


Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                 345                 350         


Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                 360                 365             


Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                 375                 380                 


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
385                 390                 395                 400 


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410         


<210>  69
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ser Ile Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile 
1               5                   10                  15      


Gln Gly Asn Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn 
            20                  25                  30          


Ser Leu Ile Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu 
        35                  40                  45              


Ser Lys Gln Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro 
    50                  55                  60                  


Lys Ala Glu Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser 
65                  70                  75                  80  


Ala Phe Gln Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln 
                85                  90                  95      


Arg Arg Tyr Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu 
            100                 105                 110         


Glu Pro Pro Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val 
        115                 120                 125             


Val Ala Asn Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser 
    130                 135                 140                 


His Arg Gly Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr 
145                 150                 155                 160 


Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu 
                165                 170                 175     


Gly Glu Ile Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu 
            180                 185                 190         


Thr Arg Cys Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile 
        195                 200                 205             


Asp Asp Lys His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val 
    210                 215                 220                 


Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile 
225                 230                 235                 240 


Arg Ile Asp Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg 
                245                 250                 255     


Thr 
    


<210>  70
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Lys Gly 
            20                  25                  30          


Val Ser Arg Arg Leu Pro Arg Arg Pro Arg Ile Ala Pro Arg Thr Pro 
        35                  40                  45              


Gln Pro Ala Gln Pro Arg Thr Gly Ala Pro Ala Arg Ala Arg Ala Pro 
    50                  55                  60                  


Ala Arg Pro Phe Leu Phe Pro 
65                  70      


<210>  71
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  72
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  72

Tyr Gly Gln Val Pro Met Cys Asp Ala Gly Glu Gln Cys Ala Val Arg 
1               5                   10                  15      


Lys Gly Ala Arg Ile Gly Lys Leu Cys Asp Cys Pro Arg Gly Thr Ser 
            20                  25                  30          


Cys Asn Ser Phe Leu Leu Lys Cys Leu 
        35                  40      


<210>  73
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Lys Ile Leu Val Ala Leu Ala Val Phe Phe Leu Val Ser Thr Gln 
1               5                   10                  15      


Leu Phe Ala Glu Glu Ile Gly Ala Asn Asp Asp Leu Asn Tyr Trp Ser 
            20                  25                  30          


Asp Trp Tyr Asp Ser Asp Gln Ile Lys Glu Glu Leu Pro Glu Pro Phe 
        35                  40                  45              


Glu His Leu Leu Gln Arg Ile Ala Arg Arg Pro Lys Pro Gln Gln Phe 
    50                  55                  60                  


Phe Gly Leu Met Gly Lys Arg Asp Ala Asp Ser Ser Ile Glu Lys Gln 
65                  70                  75                  80  


Val Ala Leu Leu Lys Ala Leu Tyr Gly His Gly Gln Ile Ser His Lys 
                85                  90                  95      


Arg His Lys Thr Asp Ser Phe Val Gly Leu Met Gly Lys Arg Ala Leu 
            100                 105                 110         


Asn Ser Val Ala Tyr Glu Arg Ser Ala Met Gln Asn Tyr Glu Arg Arg 
        115                 120                 125             


Arg 
    


<210>  74
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  74

Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met 
1               5                   10      


<210>  75
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Gly Pro Ser Leu Ala Cys Cys Leu Leu Gly Leu Leu Ala Leu 
1               5                   10                  15      


Thr Ser Ala Cys Tyr Ile Gln Asn Cys Pro Leu Gly Gly Lys Arg Ala 
            20                  25                  30          


Ala Pro Asp Leu Asp Val Arg Lys Cys Leu Pro Cys Gly Pro Gly Gly 
        35                  40                  45              


Lys Gly Arg Cys Phe Gly Pro Asn Ile Cys Cys Ala Glu Glu Leu Gly 
    50                  55                  60                  


Cys Phe Val Gly Thr Ala Glu Ala Leu Arg Cys Gln Glu Glu Asn Tyr 
65                  70                  75                  80  


Leu Pro Ser Pro Cys Gln Ser Gly Gln Lys Ala Cys Gly Ser Gly Gly 
                85                  90                  95      


Arg Cys Ala Val Leu Gly Leu Cys Cys Ser Pro Asp Gly Cys His Ala 
            100                 105                 110         


Asp Pro Ala Cys Asp Ala Glu Ala Thr Phe Ser Gln Arg 
        115                 120                 125 


<210>  76
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  76

Cys Tyr Ile Gln Asn Cys Pro Leu Gly 
1               5                   


<210>  77
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Leu Ser Cys Arg Leu Gln Cys Ala Leu Ala Ala Leu Ser Ile Val 
1               5                   10                  15      


Leu Ala Leu Gly Cys Val Thr Gly Ala Pro Ser Asp Pro Arg Leu Arg 
            20                  25                  30          


Gln Phe Leu Gln Lys Ser Leu Ala Ala Ala Ala Gly Lys Gln Glu Leu 
        35                  40                  45              


Ala Lys Tyr Phe Leu Ala Glu Leu Leu Ser Glu Pro Asn Gln Thr Glu 
    50                  55                  60                  


Asn Asp Ala Leu Glu Pro Glu Asp Leu Ser Gln Ala Ala Glu Gln Asp 
65                  70                  75                  80  


Glu Met Arg Leu Glu Leu Gln Arg Ser Ala Asn Ser Asn Pro Ala Met 
                85                  90                  95      


Ala Pro Arg Glu Arg Lys Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr 
            100                 105                 110         


Phe Thr Ser Cys 
        115     


<210>  78
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct of Myosin light chain kinase, Green 
       fluorescent protein, Calmodulin chimera


<220>
<221>  misc_feature
<222>  (223)..(223)
<223>  Xaa can be any naturally occurring amino acid

<400>  78

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Leu Ala Thr Met Val Asp Ser Ser Arg Arg Lys Trp Asn Lys Thr Gly 
        35                  40                  45              


His Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Leu Glu Asn Val Tyr 
    50                  55                  60                  


Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile 
65                  70                  75                  80  


Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr His Tyr Gln 
                85                  90                  95      


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            100                 105                 110         


Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        115                 120                 125             


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
    130                 135                 140                 


Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser 
145                 150                 155                 160 


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
                165                 170                 175     


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
            180                 185                 190         


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
        195                 200                 205             


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Xaa Val 
    210                 215                 220                 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
225                 230                 235                 240 


Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Phe Phe 
                245                 250                 255     


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
            260                 265                 270         


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
        275                 280                 285             


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Thr Arg Asp Gln 
    290                 295                 300                 


Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe Ser Leu Phe 
305                 310                 315                 320 


Asp Lys Asp Gly Asp Gly Gly Ile Thr Thr Lys Gln Leu Gly Thr Val 
                325                 330                 335     


Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met 
            340                 345                 350         


Ile Asn Glu Val Gly Ala Asp Gly Asn Gly Thr Ile Asp Phe Pro Gln 
        355                 360                 365             


Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp Ser Glu Glu 
    370                 375                 380                 


Glu Ile Arg Glu Ala Phe Arg Val Phe Gly Lys Asp Gly Asn Gly Tyr 
385                 390                 395                 400 


Ile Ser Ala Ala Gln Leu Arg His Val Met Thr Asn Leu Gly Glu Lys 
                405                 410                 415     


Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Gly Ile Asp 
            420                 425                 430         


Gly Asp Gly Gln Val Asn Tyr Glu Gln Phe Val Gln Met Met Thr Ala 
        435                 440                 445             


Lys 
    


<210>  79
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct of Genetically-encoded green calcium 
       indicator NTnC


<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be any naturally occurring amino acid

<400>  79

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ser Leu Pro Ala Thr 
1               5                   10                  15      


His Glu Leu His Ile Phe Gly Ser Ile Asn Gly Val Asp Phe Asp Met 
            20                  25                  30          


Val Gly Gln Gly Ser Gly Asn Pro Asn Val Gly Tyr Glu Glu Leu Asn 
        35                  40                  45              


Leu Lys Ser Thr Lys Gly Asp Leu Gln Phe Ser Pro Trp Ile Leu Val 
    50                  55                  60                  


Pro His Ile Xaa Phe His Gln Tyr Leu Pro Tyr Pro Asp Gly Met Ser 
65                  70                  75                  80  


Pro Phe Gln Ala Ala Met Val Asp Gly Ser Gly Tyr Gln Val His Arg 
                85                  90                  95      


Thr Val Gln Phe Glu Asp Gly Ala Ser Leu Thr Val Asn Tyr Arg Tyr 
            100                 105                 110         


Thr Tyr Glu Gly Ser His Ile Lys Gly Glu Ala Gln Val Lys Gly Thr 
        115                 120                 125             


Gly Phe Pro Ala Asp Gly Pro Val Met Ala Asn Ser Leu Thr Ala Met 
    130                 135                 140                 


Val Pro Ser Glu Glu Glu Leu Ser Glu Cys Phe Arg Thr Phe Asp Lys 
145                 150                 155                 160 


Asp Gly Asp Gly Phe Ile Asp Arg Glu Glu Phe Gly Gly Ile Ile Arg 
                165                 170                 175     


Leu Thr Gly Glu Gln Leu Thr Asp Glu Asp Pro Asp Glu Ile Phe Gly 
            180                 185                 190         


Asp Ser Asp Thr Asp Lys Asn Gly Arg Ile Asp Phe Asp Glu Phe Leu 
        195                 200                 205             


Lys Met Val Glu Asn Val Gln Leu Ser Met Ala Asp Trp Cys Arg Ser 
    210                 215                 220                 


Lys Met Ala Cys Pro Asn Asp Lys Thr Leu Ile Ser Thr Leu Lys Trp 
225                 230                 235                 240 


Ser Tyr Thr Thr Gly Asn Gly Lys Arg Tyr Arg Ser Thr Ala Arg Thr 
                245                 250                 255     


Thr Tyr Thr Phe Ala Lys Pro Met Ala Ala Asn Tyr Leu Lys Asn Gln 
            260                 265                 270         


Pro Met Tyr Val Phe Arg Lys Thr Glu Leu Lys His Ser Lys Thr Glu 
        275                 280                 285             


Leu Asn Phe Lys Glu Trp Gln Lys Ala Phe Thr Asp Val Met Gly Met 
    290                 295                 300                 


Asp Glu Leu Tyr Lys 
305                 


<210>  80
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct of Calcium indicator TN-XXL

<400>  80

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala His Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Arg Met Leu Ser Glu Glu Glu Leu Ala Asn Cys Phe 
225                 230                 235                 240 


Arg Ile Phe Asp Lys Asp Ala Asn Gly Phe Ile Asp Ile Glu Glu Leu 
                245                 250                 255     


Gly Glu Ile Leu Arg Ala Thr Gly Glu His Val Thr Glu Glu Asp Ile 
            260                 265                 270         


Glu Asp Leu Met Lys Asp Ser Asp Lys Asn Asn Asp Gly Arg Ile Asp 
        275                 280                 285             


Phe Asp Glu Phe Leu Lys Met Met Glu Gly Val Gln Gly Thr Ser Glu 
    290                 295                 300                 


Glu Glu Leu Ala Asn Cys Phe Arg Ile Phe Asp Lys Asp Ala Asn Gly 
305                 310                 315                 320 


Phe Ile Asp Ile Glu Glu Leu Gly Glu Ile Leu Arg Ala Thr Gly Glu 
                325                 330                 335     


His Val Thr Glu Glu Asp Ile Glu Asp Leu Met Lys Asp Ser Asp Lys 
            340                 345                 350         


Asn Asn Asp Gly Arg Ile Asp Phe Asp Glu Phe Leu Lys Met Met Glu 
        355                 360                 365             


Gly Val Gln Glu Leu Met Gly Gly Val Gln Leu Ala Asp His Tyr Gln 
    370                 375                 380                 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
385                 390                 395                 400 


Tyr Leu Ser Tyr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg 
                405                 410                 415     


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
            420                 425                 430         


Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser 
        435                 440                 445             


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
    450                 455                 460                 


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu 
465                 470                 475                 480 


Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
                485                 490                 495     


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr 
            500                 505                 510         


Gly Leu Met Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
        515                 520                 525             


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
    530                 535                 540                 


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
545                 550                 555                 560 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
                565                 570                 575     


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
            580                 585                 590         


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
        595                 600                 605             


Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
    610                 615                 


<210>  81
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct of BRET-based auto-luminescent calcium 
       indicator

<400>  81

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Arg 
225                 230                 235                 240 


Met His Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
                245                 250                 255     


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            260                 265                 270         


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        275                 280                 285             


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 
    290                 295                 300                 


Tyr Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr 
305                 310                 315                 320 


Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                325                 330                 335     


Gly Asn Gly Tyr Ile Ser Ala Ala Gln Leu Arg His Val Met Thr Asn 
            340                 345                 350         


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        355                 360                 365             


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    370                 375                 380                 


Met Met Thr Ala Lys Gly Gly Lys Arg Arg Trp Lys Lys Asn Phe Ile 
385                 390                 395                 400 


Ala Val Ser Ala Ala Asn Arg Phe Lys Lys Ile Ser Ser Ser Gly Ala 
                405                 410                 415     


Leu Glu Leu Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg 
            420                 425                 430         


Met Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val 
        435                 440                 445             


Leu Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn 
    450                 455                 460                 


Ala Val Ile Phe Leu His Gly Asn Ala Thr Ser Ser Tyr Leu Trp Arg 
465                 470                 475                 480 


His Val Val Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp 
                485                 490                 495     


Leu Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg 
            500                 505                 510         


Leu Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn 
        515                 520                 525             


Leu Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu 
    530                 535                 540                 


Ala Phe His Tyr Ala Tyr Glu His Gln Asp Arg Ile Lys Ala Ile Val 
545                 550                 555                 560 


His Met Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro 
                565                 570                 575     


Asp Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys 
            580                 585                 590         


Met Val Leu Glu Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys 
        595                 600                 605             


Ile Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro 
    610                 615                 620                 


Phe Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg 
625                 630                 635                 640 


Glu Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val 
                645                 650                 655     


Arg Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Leu 
            660                 665                 670         


Phe Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly 
        675                 680                 685             


Ala Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His 
    690                 695                 700                 


Phe Leu Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser 
705                 710                 715                 720 


Phe Val Glu Arg Val Leu Lys Asn Glu Gln 
                725                 730 


<210>  82
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct of Calcium indicator protein OeNL(Ca2+)-18u

<400>  82

Met Val Ser Val Ile Lys Pro Glu Met Lys Met Arg Tyr Tyr Met Asp 
1               5                   10                  15      


Gly Ser Val Asn Gly His Glu Phe Thr Ile Glu Gly Glu Gly Thr Gly 
            20                  25                  30          


Arg Pro Tyr Glu Gly His Gln Glu Met Thr Leu Arg Val Thr Met Ala 
        35                  40                  45              


Glu Gly Gly Pro Met Pro Phe Ala Phe Asp Leu Val Ser His Val Phe 
    50                  55                  60                  


Cys Tyr Gly His Arg Val Phe Thr Lys Tyr Pro Glu Glu Ile Pro Asp 
65                  70                  75                  80  


Tyr Phe Lys Gln Ala Phe Pro Glu Gly Leu Ser Trp Glu Arg Ser Leu 
                85                  90                  95      


Glu Phe Glu Asp Gly Gly Ser Ala Ser Val Ser Ala His Ile Ser Leu 
            100                 105                 110         


Arg Gly Asn Thr Phe Tyr His Lys Ser Lys Phe Thr Gly Val Asn Phe 
        115                 120                 125             


Pro Ala Asp Gly Pro Ile Met Gln Asn Gln Ser Val Asp Trp Glu Pro 
    130                 135                 140                 


Ser Thr Glu Lys Ile Thr Ala Ser Asp Gly Val Leu Lys Gly Asp Val 
145                 150                 155                 160 


Thr Met Tyr Leu Lys Leu Glu Gly Gly Gly Asn His Lys Cys Gln Phe 
                165                 170                 175     


Lys Thr Thr Tyr Lys Ala Ala Lys Glu Ile Leu Glu Met Pro Gly Asp 
            180                 185                 190         


His Tyr Ile Gly His Arg Leu Val Arg Lys Thr Glu Gly Asn Ile Thr 
        195                 200                 205             


Glu Gln Val Glu Asp Ala Val Ala His Ser Gly Thr Leu Glu Asp Phe 
    210                 215                 220                 


Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu 
225                 230                 235                 240 


Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val 
                245                 250                 255     


Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile 
            260                 265                 270         


Asp Ile His Val Ile Ile Pro Tyr Glu Gly Pro Trp Met His Asp Gln 
        275                 280                 285             


Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe Ser Leu Phe 
    290                 295                 300                 


Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu Gly Thr Val 
305                 310                 315                 320 


Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met 
                325                 330                 335     


Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Tyr Phe Pro Asp 
            340                 345                 350         


Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp Ser Glu Glu 
        355                 360                 365             


Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr 
    370                 375                 380                 


Ile Ser Ala Ala Asp Leu Arg His Val Met Thr Asn Leu Gly Glu Lys 
385                 390                 395                 400 


Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile Asp 
                405                 410                 415     


Gly Glu Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr Ala 
            420                 425                 430         


Lys Gly Gly Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala 
        435                 440                 445             


Ala Asn Arg Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu Glu Leu Leu 
    450                 455                 460                 


Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val Val Tyr 
465                 470                 475                 480 


Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly Thr Leu 
                485                 490                 495     


Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro 
            500                 505                 510         


Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly 
        515                 520                 525             


Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Asn Pro 
    530                 535                 540                 


Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr Gly Trp 
545                 550                 555                 560 


Arg Leu Cys Glu Arg Ile Leu Ala 
                565             


<210>  83
<211>  593
<212>  PRT
<213>  Mesostigma viride

<400>  83

Met Ser Pro Pro Thr Ser Pro Thr Pro Asp Thr Gly His Asp Thr Pro 
1               5                   10                  15      


Asp Thr Gly His Asp Thr Gly Gly His Gly Ala Val Glu Ile Cys Phe 
            20                  25                  30          


Ala Pro Cys Glu Glu Asp Cys Val Thr Ile Arg Tyr Phe Val Glu Asn 
        35                  40                  45              


Asp Phe Glu Gly Cys Ile Pro Gly His Phe Asp Gln Tyr Ser Ser His 
    50                  55                  60                  


Gly Ser Leu His Asp Ile Val Lys Ala Ala Leu Tyr Ile Cys Met Val 
65                  70                  75                  80  


Ile Ser Ile Leu Gln Ile Leu Phe Tyr Gly Phe Gln Trp Trp Arg Lys 
                85                  90                  95      


Thr Cys Gly Trp Glu Val Trp Phe Val Ala Cys Ile Glu Thr Ser Ile 
            100                 105                 110         


Tyr Ile Ile Ala Ile Thr Ser Glu Ala Asp Ser Pro Phe Thr Leu Tyr 
        115                 120                 125             


Leu Thr Asn Gly Gln Ile Ser Pro Gln Leu Arg Tyr Met Glu Trp Leu 
    130                 135                 140                 


Met Thr Cys Pro Val Ile Leu Ile Ala Leu Ser Asn Ile Thr Gly Met 
145                 150                 155                 160 


Ala Glu Glu Tyr Asn Lys Arg Thr Met Thr Leu Leu Thr Ser Asp Val 
                165                 170                 175     


Cys Cys Ile Val Leu Gly Met Met Ser Ala Ala Ser Lys Pro Arg Leu 
            180                 185                 190         


Lys Gly Ile Leu Tyr Ala Val Gly Trp Ala Phe Gly Ala Trp Thr Tyr 
        195                 200                 205             


Trp Thr Ala Leu Gln Val Tyr Arg Asp Ala His Lys Ala Val Pro Lys 
    210                 215                 220                 


Pro Leu Ala Trp Tyr Val Arg Ala Met Gly Tyr Val Phe Phe Thr Ser 
225                 230                 235                 240 


Trp Leu Thr Phe Pro Gly Trp Phe Leu Leu Gly Pro Glu Gly Leu Glu 
                245                 250                 255     


Val Val Thr Gly Thr Val Ser Thr Leu Met His Ala Cys Ser Asp Leu 
            260                 265                 270         


Ile Ser Lys Asn Leu Trp Gly Phe Met Asp Trp His Leu Arg Val Leu 
        275                 280                 285             


Val Ala Arg His His Arg Lys Leu Phe Lys Ala Glu Glu Glu His Ala 
    290                 295                 300                 


Leu Lys Lys Gly Gln Thr Leu Glu Pro Gly Met Pro Arg Ser Thr Ser 
305                 310                 315                 320 


Phe Val Arg Gly Leu Gly Asp Asp Val Glu Ile Asp Pro Ser Tyr Glu 
                325                 330                 335     


Leu Tyr Arg Leu Lys Arg Gln Asn His Pro Glu Tyr Phe Leu Ser Pro 
            340                 345                 350         


Ala Gln Thr Pro Arg Arg Gly Pro Ser Phe Asp Lys Arg Thr Ser Phe 
        355                 360                 365             


Glu Met Asp Gly Gly Lys Asn Gly Met Leu Gln Met Met Pro Val Thr 
    370                 375                 380                 


Gly Met Gly Met Gly Met Gly Met Gly Met Gly Gly Gly Lys Thr Val 
385                 390                 395                 400 


Leu Phe Leu Asp Tyr Thr Gly Gly Gly Tyr Val Ser Phe Phe Glu Gln 
                405                 410                 415     


Gln Leu Ser Asn Met Gly Val Asn Val Thr Lys Cys Trp Ser Asp Asp 
            420                 425                 430         


Asp Met Tyr Asn Thr Ala Gly Val Ala Asn Val Lys Gln Leu Phe His 
        435                 440                 445             


Phe Ala Met Ile Pro Asn Asn Ala Leu Gly Gly Gln Met Val Met Asp 
    450                 455                 460                 


Leu Arg Gly Thr Gly Leu Leu Val Val Ala Tyr Gly Pro Glu Pro Pro 
465                 470                 475                 480 


Met Pro Gly Met Gly Gln Asp Glu Phe Val Pro Leu Gln Met Pro Gly 
                485                 490                 495     


Val Pro Tyr Asp Glu Ser Ile Leu His Asn Leu Val Met Arg His Ala 
            500                 505                 510         


Ile Thr Gln Gly Leu Gly Met Asn Gly Met Gln Gly Asn Met Gly Gln 
        515                 520                 525             


Gln Gln Gln Met Met Gly Met Gln Gly Asn Met Asn Gly Met Gln Gly 
    530                 535                 540                 


Asn Met Asn Gly Met Gln Gly Asn Met Asn Gly Met Gln Gly Asn Met 
545                 550                 555                 560 


Ser Gly Met Gln Gly Asn Met Asn Gly Met Gln Gly Asn Ser Gly Met 
                565                 570                 575     


Asn Gln Gly Trp Asn Asn Gln Gly Phe Thr Asn Thr Gly Ala Phe Gly 
            580                 585                 590         


Tyr 
    


<210>  84
<211>  747
<212>  PRT
<213>  Volvox carteri

<400>  84

Met Asp His Pro Val Ala Arg Ser Leu Ile Gly Ser Ser Tyr Thr Asn 
1               5                   10                  15      


Leu Asn Asn Gly Ser Ile Val Ile Pro Ser Asp Ala Cys Phe Cys Met 
            20                  25                  30          


Lys Trp Leu Lys Ser Lys Gly Ser Pro Val Ala Leu Lys Met Ala Asn 
        35                  40                  45              


Ala Leu Gln Trp Ala Ala Phe Ala Leu Ser Val Ile Ile Leu Ile Tyr 
    50                  55                  60                  


Tyr Ala Tyr Ala Thr Trp Arg Thr Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Cys Cys Val Glu Leu Thr Lys Val Val Ile Glu Phe Phe His Glu 
                85                  90                  95      


Phe Asp Glu Pro Gly Met Leu Tyr Leu Ala Asn Gly Asn Arg Val Leu 
            100                 105                 110         


Trp Leu Arg Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Asn Lys Arg Thr 
    130                 135                 140                 


Met Arg Leu Leu Val Ser Asp Val Gly Thr Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ala Ala Met Ser Thr Gly Tyr Ile Lys Val Ile Phe Phe Leu Leu Gly 
                165                 170                 175     


Cys Met Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ser Tyr His Thr Val Pro Lys Gly Leu Cys Arg Gln Leu Val Arg 
        195                 200                 205             


Ala Met Ala Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Pro Glu Gly Phe Gly His Leu Ser Val Tyr Gly Ser 
225                 230                 235                 240 


Thr Ile Gly His Thr Ile Ile Asp Leu Leu Ser Lys Asn Cys Trp Gly 
                245                 250                 255     


Leu Leu Gly His Phe Leu Arg Leu Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Val Gln Lys Ile Arg Val Ala Gly Glu Glu 
        275                 280                 285             


Leu Glu Val Glu Thr Leu Met Thr Glu Glu Ala Pro Asp Thr Val Lys 
    290                 295                 300                 


Lys Ser Thr Ala Gln Tyr Ala Asn Arg Glu Ser Phe Leu Thr Met Arg 
305                 310                 315                 320 


Asp Lys Leu Lys Glu Lys Gly Phe Glu Val Arg Ala Ser Leu Asp Asn 
                325                 330                 335     


Ser Gly Ile Asp Ala Val Ile Asn His Asn Asn Asn Tyr Asn Asn Ala 
            340                 345                 350         


Leu Ala Asn Ala Ala Ala Ala Val Gly Lys Pro Gly Met Glu Leu Ser 
        355                 360                 365             


Lys Leu Asp His Val Ala Ala Asn Ala Ala Gly Met Gly Gly Ile Ala 
    370                 375                 380                 


Asp His Val Ala Thr Thr Ser Gly Ala Ile Ser Pro Gly Arg Val Ile 
385                 390                 395                 400 


Leu Ala Val Pro Asp Ile Ser Met Val Asp Tyr Phe Arg Glu Gln Phe 
                405                 410                 415     


Ala Gln Leu Pro Val Gln Tyr Glu Val Val Pro Ala Leu Gly Ala Asp 
            420                 425                 430         


Asn Ala Val Gln Leu Val Val Gln Ala Ala Gly Leu Gly Gly Cys Asp 
        435                 440                 445             


Phe Val Leu Leu His Pro Glu Phe Leu Arg Asp Lys Ser Ser Thr Ser 
    450                 455                 460                 


Leu Pro Ala Arg Leu Arg Ser Ile Gly Gln Arg Val Ala Ala Phe Gly 
465                 470                 475                 480 


Trp Ser Pro Val Gly Pro Val Arg Asp Leu Ile Glu Ser Ala Gly Leu 
                485                 490                 495     


Asp Gly Trp Leu Glu Gly Pro Ser Phe Gly Leu Gly Ile Ser Leu Pro 
            500                 505                 510         


Asn Leu Ala Ser Leu Val Leu Arg Met Gln His Ala Arg Lys Met Ala 
        515                 520                 525             


Ala Met Leu Gly Gly Met Gly Gly Met Leu Gly Ser Asn Leu Met Ser 
    530                 535                 540                 


Gly Ser Gly Gly Val Gly Leu Met Gly Ala Gly Ser Pro Gly Gly Gly 
545                 550                 555                 560 


Gly Gly Ala Met Gly Val Gly Met Thr Gly Met Gly Met Val Gly Thr 
                565                 570                 575     


Asn Ala Met Gly Arg Gly Ala Val Gly Asn Ser Val Ala Asn Ala Ser 
            580                 585                 590         


Met Gly Gly Gly Ser Ala Gly Met Gly Met Gly Met Met Gly Met Val 
        595                 600                 605             


Gly Ala Gly Val Gly Gly Gln Gln Gln Met Gly Ala Asn Gly Met Gly 
    610                 615                 620                 


Pro Thr Ser Phe Gln Leu Gly Ser Asn Pro Leu Tyr Asn Thr Ala Pro 
625                 630                 635                 640 


Ser Pro Leu Ser Ser Gln Pro Gly Gly Asp Ala Ser Ala Ala Ala Ala 
                645                 650                 655     


Ala Ala Ala Ala Ala Ala Ala Thr Gly Ala Ala Ser Asn Ser Met Asn 
            660                 665                 670         


Ala Met Gln Ala Gly Gly Ser Val Arg Asn Ser Gly Ile Leu Ala Gly 
        675                 680                 685             


Gly Leu Gly Ser Met Met Gly Pro Pro Gly Ala Pro Ala Ala Pro Thr 
    690                 695                 700                 


Ala Ala Ala Thr Ala Ala Pro Ala Val Thr Met Gly Ala Pro Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Ala Ala Ser Glu Ala Glu Met Leu Gln Gln Leu Met Ala 
                725                 730                 735     


Glu Ile Asn Arg Leu Lys Ser Glu Leu Gly Glu 
            740                 745         


<210>  85
<211>  282
<212>  PRT
<213>  Streptococcus pyogenes

<400>  85

Met Leu Glu His Lys Ile Asp Phe Met Val Thr Leu Glu Val Lys Glu 
1               5                   10                  15      


Ala Asn Ala Asn Gly Asp Pro Leu Asn Gly Asn Met Pro Arg Thr Asp 
            20                  25                  30          


Ala Lys Gly Tyr Gly Val Met Ser Asp Val Ser Ile Lys Arg Lys Ile 
        35                  40                  45              


Arg Asn Arg Leu Gln Asp Met Gly Lys Ser Ile Phe Val Gln Ala Asn 
    50                  55                  60                  


Glu Arg Ile Glu Asp Asp Phe Arg Ser Leu Glu Lys Arg Phe Ser Gln 
65                  70                  75                  80  


His Phe Thr Ala Lys Thr Pro Asp Lys Glu Ile Glu Glu Lys Ala Asn 
                85                  90                  95      


Ala Leu Trp Phe Asp Val Arg Ala Phe Gly Gln Val Phe Thr Tyr Leu 
            100                 105                 110         


Lys Lys Ser Ile Gly Val Arg Gly Pro Val Ser Ile Ser Met Ala Lys 
        115                 120                 125             


Ser Leu Glu Pro Ile Val Ile Ser Ser Leu Gln Ile Thr Arg Ser Thr 
    130                 135                 140                 


Asn Gly Met Glu Ala Lys Asn Asn Ser Gly Arg Ser Ser Asp Thr Met 
145                 150                 155                 160 


Gly Thr Lys His Phe Val Asp Tyr Gly Val Tyr Val Leu Lys Gly Ser 
                165                 170                 175     


Ile Asn Ala Tyr Phe Ala Glu Lys Thr Gly Phe Ser Gln Glu Asp Ala 
            180                 185                 190         


Glu Ala Ile Lys Glu Val Leu Val Ser Leu Phe Glu Asn Asp Ala Ser 
        195                 200                 205             


Ser Ala Arg Pro Glu Gly Ser Met Arg Val Cys Glu Val Phe Trp Phe 
    210                 215                 220                 


Thr His Ser Ser Lys Leu Gly Asn Val Ser Ser Ala Arg Val Phe Asp 
225                 230                 235                 240 


Leu Leu Glu Tyr His Gln Ser Ile Glu Glu Lys Ser Thr Tyr Asp Ala 
                245                 250                 255     


Tyr Gln Ile His Leu Asn Gln Glu Lys Leu Ala Lys Tyr Glu Ala Lys 
            260                 265                 270         


Gly Leu Thr Leu Glu Ile Leu Glu Gly Leu 
        275                 280         


<210>  86
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cas9

<400>  86

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  87
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp. BV3L6

<400>  87

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  88
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Glu Ser Arg Asp His Asn Asn Pro Gln Glu Gly Pro Thr Ser Ser 
1               5                   10                  15      


Ser Gly Arg Arg Ala Ala Val Glu Asp Asn His Leu Leu Ile Lys Ala 
            20                  25                  30          


Val Gln Asn Glu Asp Val Asp Leu Val Gln Gln Leu Leu Glu Gly Gly 
        35                  40                  45              


Ala Asn Val Asn Phe Gln Glu Glu Glu Gly Gly Trp Thr Pro Leu His 
    50                  55                  60                  


Asn Ala Val Gln Met Ser Arg Glu Asp Ile Val Glu Leu Leu Leu Arg 
65                  70                  75                  80  


His Gly Ala Asp Pro Val Leu Arg Lys Lys Asn Gly Ala Thr Pro Phe 
                85                  90                  95      


Ile Leu Ala Ala Ile Ala Gly Ser Val Lys Leu Leu Lys Leu Phe Leu 
            100                 105                 110         


Ser Lys Gly Ala Asp Val Asn Glu Cys Asp Phe Tyr Gly Phe Thr Ala 
        115                 120                 125             


Phe Met Glu Ala Ala Val Tyr Gly Lys Val Lys Ala Leu Lys Phe Leu 
    130                 135                 140                 


Tyr Lys Arg Gly Ala Asn Val Asn Leu Arg Arg Lys Thr Lys Glu Asp 
145                 150                 155                 160 


Gln Glu Arg Leu Arg Lys Gly Gly Ala Thr Ala Leu Met Asp Ala Ala 
                165                 170                 175     


Glu Lys Gly His Val Glu Val Leu Lys Ile Leu Leu Asp Glu Met Gly 
            180                 185                 190         


Ala Asp Val Asn Ala Cys Asp Asn Met Gly Arg Asn Ala Leu Ile His 
        195                 200                 205             


Ala Leu Leu Ser Ser Asp Asp Ser Asp Val Glu Ala Ile Thr His Leu 
    210                 215                 220                 


Leu Leu Asp His Gly Ala Asp Val Asn Val Arg Gly Glu Arg Gly Lys 
225                 230                 235                 240 


Thr Pro Leu Ile Leu Ala Val Glu Lys Lys His Leu Gly Leu Val Gln 
                245                 250                 255     


Arg Leu Leu Glu Gln Glu His Ile Glu Ile Asn Asp Thr Asp Ser Asp 
            260                 265                 270         


Gly Lys Thr Ala Leu Leu Leu Ala Val Glu Leu Lys Leu Lys Lys Ile 
        275                 280                 285             


Ala Glu Leu Leu Cys Lys Arg Gly Ala Ser Thr Asp Cys Gly Asp Leu 
    290                 295                 300                 


Val Met Thr Ala Arg Arg Asn Tyr Asp His Ser Leu Val Lys Val Leu 
305                 310                 315                 320 


Leu Ser His Gly Ala Lys Glu Asp Phe His Pro Pro Ala Glu Asp Trp 
                325                 330                 335     


Lys Pro Gln Ser Ser His Trp Gly Ala Ala Leu Lys Asp Leu His Arg 
            340                 345                 350         


Ile Tyr Arg Pro Met Ile Gly Lys Leu Lys Phe Phe Ile Asp Glu Lys 
        355                 360                 365             


Tyr Lys Ile Ala Asp Thr Ser Glu Gly Gly Ile Tyr Leu Gly Phe Tyr 
    370                 375                 380                 


Glu Lys Gln Glu Val Ala Val Lys Thr Phe Cys Glu Gly Ser Pro Arg 
385                 390                 395                 400 


Ala Gln Arg Glu Val Ser Cys Leu Gln Ser Ser Arg Glu Asn Ser His 
                405                 410                 415     


Leu Val Thr Phe Tyr Gly Ser Glu Ser His Arg Gly His Leu Phe Val 
            420                 425                 430         


Cys Val Thr Leu Cys Glu Gln Thr Leu Glu Ala Cys Leu Asp Val His 
        435                 440                 445             


Arg Gly Glu Asp Val Glu Asn Glu Glu Asp Glu Phe Ala Arg Asn Val 
    450                 455                 460                 


Leu Ser Ser Ile Phe Lys Ala Val Gln Glu Leu His Leu Ser Cys Gly 
465                 470                 475                 480 


Tyr Thr His Gln Asp Leu Gln Pro Gln Asn Ile Leu Ile Asp Ser Lys 
                485                 490                 495     


Lys Ala Ala His Leu Ala Asp Phe Asp Lys Ser Ile Lys Trp Ala Gly 
            500                 505                 510         


Asp Pro Gln Glu Val Lys Arg Asp Leu Glu Asp Leu Gly Arg Leu Val 
        515                 520                 525             


Leu Tyr Val Val Lys Lys Gly Ser Ile Ser Phe Glu Asp Leu Lys Ala 
    530                 535                 540                 


Gln Ser Asn Glu Glu Val Val Gln Leu Ser Pro Asp Glu Glu Thr Lys 
545                 550                 555                 560 


Asp Leu Ile His Arg Leu Phe His Pro Gly Glu His Val Arg Asp Cys 
                565                 570                 575     


Leu Ser Asp Leu Leu Gly His Pro Phe Phe Trp Thr Trp Glu Ser Arg 
            580                 585                 590         


Tyr Arg Thr Leu Arg Asn Val Gly Asn Glu Ser Asp Ile Lys Thr Arg 
        595                 600                 605             


Lys Ser Glu Ser Glu Ile Leu Arg Leu Leu Gln Pro Gly Pro Ser Glu 
    610                 615                 620                 


His Ser Lys Ser Phe Asp Lys Trp Thr Thr Lys Ile Asn Glu Cys Val 
625                 630                 635                 640 


Met Lys Lys Met Asn Lys Phe Tyr Glu Lys Arg Gly Asn Phe Tyr Gln 
                645                 650                 655     


Asn Thr Val Gly Asp Leu Leu Lys Phe Ile Arg Asn Leu Gly Glu His 
            660                 665                 670         


Ile Asp Glu Glu Lys His Lys Lys Met Lys Leu Lys Ile Gly Asp Pro 
        675                 680                 685             


Ser Leu Tyr Phe Gln Lys Thr Phe Pro Asp Leu Val Ile Tyr Val Tyr 
    690                 695                 700                 


Thr Lys Leu Gln Asn Thr Glu Tyr Arg Lys His Phe Pro Gln Thr His 
705                 710                 715                 720 


Ser Pro Asn Lys Pro Gln Cys Asp Gly Ala Gly Gly Ala Ser Gly Leu 
                725                 730                 735     


Ala Ser Pro Gly Cys 
            740     


<210>  89
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Met Ala Arg Leu Leu Arg Thr Ser Phe Ala Leu Leu Phe Leu Gly 
1               5                   10                  15      


Leu Phe Gly Val Leu Gly Ala Ala Thr Ile Ser Cys Arg Asn Glu Glu 
            20                  25                  30          


Gly Lys Ala Val Asp Trp Phe Thr Phe Tyr Lys Leu Pro Lys Arg Gln 
        35                  40                  45              


Asn Lys Glu Ser Gly Glu Thr Gly Leu Glu Tyr Leu Tyr Leu Asp Ser 
    50                  55                  60                  


Thr Thr Arg Ser Trp Arg Lys Ser Glu Gln Leu Met Asn Asp Thr Lys 
65                  70                  75                  80  


Ser Val Leu Gly Arg Thr Leu Gln Gln Leu Tyr Glu Ala Tyr Ala Ser 
                85                  90                  95      


Lys Ser Asn Asn Thr Ala Tyr Leu Ile Tyr Asn Asp Gly Val Pro Lys 
            100                 105                 110         


Pro Val Asn Tyr Ser Arg Lys Tyr Gly His Thr Lys Gly Leu Leu Leu 
        115                 120                 125             


Trp Asn Arg Val Gln Gly Phe Trp Leu Ile His Ser Ile Pro Gln Phe 
    130                 135                 140                 


Pro Pro Ile Pro Glu Glu Gly Tyr Asp Tyr Pro Pro Thr Gly Arg Arg 
145                 150                 155                 160 


Asn Gly Gln Ser Gly Ile Cys Ile Thr Phe Lys Tyr Asn Gln Tyr Glu 
                165                 170                 175     


Ala Ile Asp Ser Gln Leu Leu Val Cys Asn Pro Asn Val Tyr Ser Cys 
            180                 185                 190         


Ser Ile Pro Ala Thr Phe His Gln Glu Leu Ile His Met Pro Gln Leu 
        195                 200                 205             


Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg Leu Leu Thr Thr 
    210                 215                 220                 


Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe Ala Lys Ser Asp 
225                 230                 235                 240 


Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala Gln Arg Leu Lys 
                245                 250                 255     


Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg Gln Glu Leu Pro 
            260                 265                 270         


Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile Lys Ala Ile Lys 
        275                 280                 285             


Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp His Ala Lys Trp 
    290                 295                 300                 


Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr Cys Ile Gly Asp 
305                 310                 315                 320 


Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly Gly Phe Ile Cys 
                325                 330                 335     


Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly Leu Val Leu Tyr 
            340                 345                 350         


Tyr Glu Ser Cys Lys 
        355         


<210>  90
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PHP.eB capsid

<400>  90

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV-BR1

<400>  91

Asn Arg Gly Thr Glu Trp Asp 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV-PHP.S

<400>  92

Gln Ala Val Arg Thr Ser Leu 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV-PHP.B

<400>  93

Thr Leu Ala Val Pro Phe Lys 
1               5           


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV-PPS

<400>  94

Asp Ser Pro Ala His Pro Ser 
1               5           


<210>  95
<211>  4398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV: hI56core-minBglobin-SYFP2-WPRE3-BGHpA bottom strand

<400>  95
acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt       60

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt      120

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc      180

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa      240

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct      300

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta      360

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg      420

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc      480

ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta      540

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg      600

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt      660

tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg      720

tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta      780

aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg      840

aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg      900

tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc      960

gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg     1020

agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg     1080

aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag     1140

gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat     1200

caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc     1260

cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc     1320

ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa     1380

ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac     1440

gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt     1500

cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc     1560

gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa     1620

caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca     1680

tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat     1740

acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa     1800

aagtgccacc tgacgtctaa gaaaccatta ttatcatgac attaacctat aaaaataggc     1860

gtatcacgag gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     1920

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     1980

gtcagggcgc gtcagcgggt gttggcgggt gtcggggctg gcttaactat gcggcatcag     2040

agcagattgt actgagagtg caccataaaa ttgtaaacgt taatattttg ttaaaattcg     2100

cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc ggcaaaatcc     2160

cttataaatc aaaagaatag cccgagatag ggttgagtgt tgttccagtt tggaacaaga     2220

gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc tatcagggcg     2280

atggcccact acgtgaacca tcacccaaat caagtttttt ggggtcgagg tgccgtaaag     2340

cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga aagccggcga     2400

acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg ctggcaagtg     2460

tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg ctacagggcg     2520

cgtactatgg ttgctttgac gtatgcggtg tgaaataccg cacagatgcg taaggagaaa     2580

ataccgcatc aggcgcccct gcaggcagct gcgcgctcgc tcgctcactg aggccgcccg     2640

ggcaaagccc gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg     2700

cagagaggga gtggccaact ccatcactag gggttcctgc ggccgctcgg tccgcacgtg     2760

agatctcatg cctgctattg tcttcccaat cctccccctt gctgtcctgc cccaccccac     2820

cccccagaat agaatgacac ctactcagac aatgcgatgc aatttcctca ttttattagg     2880

aaaggacagt gggagtggca ccttccaggg tcaaggaagg cacgggggag gggcaaacaa     2940

cagatggctg gcaactagaa ggcacagtcg aagatctctc gagccacgga attgtcagtg     3000

cccaacagcc gagcccctgt ccagcagcgg gcaaggcagg cggcgatgag ttccgccgtg     3060

gcaagaacta accaggattt atacaaggag gagaaaatga aagccatacg ggaagcaata     3120

gcatgataca aaggcattaa agcagcgtat ccacatagcg taaaaggagc aacatagtta     3180

agaataccag tcaatctttc acaaattttg taatccagag gttgattatg atatcgaatt     3240

cgcggccgcg gcgcgccgtc gacttacttg tacagctcgt ccatgccgag agtgatcccg     3300

gcggcggtca cgaactccag caggaccatg tgatcgcgct tctcgttggg gtctttgctc     3360

agcttggact ggtagctcag gtagtggttg tcgggcagca gcacggggcc gtcgccgatg     3420

ggggtgttct gctggtagtg gtcggcgagc tgcacgccgc cgtcctcgat gttgtggcgg     3480

atcttgaagt tggccttgat gccgttcttc tgcttgtcgg cggtgatata gacgttgtgg     3540

ctgttgtagt tgtactccag cttgtgcccc aggatgttgc cgtcctcctt gaagtcgatg     3600

cccttcagct cgatgcggtt caccagggtg tcgccctcga acttcacctc ggcgcgggtc     3660

ttgtagttgc cgtcgtcctt gaagaagatg gtgcgctcct ggacgtagcc ttcgggcatg     3720

gcggacttga agaagtcgtg ctgcttcatg tggtcggggt agcgggcgaa gcactgcacg     3780

ccgtagccca gggtggtcac gagggtgggc cagggcacgg gcagcttgcc ggtggtgcag     3840

atcagcttca gggtcagctt gccgtaggtg gcatcgccct cgccctcgcc ggacacgctg     3900

aacttgtggc cgtttacgtc gccgtccagc tcgaccagga tgggcaccac cccggtgaac     3960

agctcctcgc ccttgctcac catggtggcg accggtagcg ctagcttcga aagatctgga     4020

tcccagaagc aaatgtaagc aatagatggc tctgccctga cttttatgcc cagcccgagc     4080

tccctgcagg tccattctct taaatgcagc cataattaga gtaatttttc atgtagcccg     4140

ctgattacag cgtttttacc gtcaaagata attacctgta attttcttcc acttttaata     4200

ctaaaaagcc atctttattt agattcagga acaggaaagg cgaacgcgtg cggccgcagg     4260

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     4320

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     4380

cgcgcagctg cctgcagg                                                   4398


<210>  96
<211>  4635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV: 3XhI56core-minBglobin-SYFP2-WPRE3-BGHpA bottom strand

<400>  96
acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt       60

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt      120

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc      180

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa      240

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct      300

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta      360

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg      420

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc      480

ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta      540

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg      600

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt      660

tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg      720

tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta      780

aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg      840

aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg      900

tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc      960

gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg     1020

agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg     1080

aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag     1140

gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat     1200

caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc     1260

cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc     1320

ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa     1380

ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac     1440

gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt     1500

cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc     1560

gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa     1620

caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca     1680

tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat     1740

acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa     1800

aagtgccacc tgacgtctaa gaaaccatta ttatcatgac attaacctat aaaaataggc     1860

gtatcacgag gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     1920

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     1980

gtcagggcgc gtcagcgggt gttggcgggt gtcggggctg gcttaactat gcggcatcag     2040

agcagattgt actgagagtg caccataaaa ttgtaaacgt taatattttg ttaaaattcg     2100

cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc ggcaaaatcc     2160

cttataaatc aaaagaatag cccgagatag ggttgagtgt tgttccagtt tggaacaaga     2220

gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc tatcagggcg     2280

atggcccact acgtgaacca tcacccaaat caagtttttt ggggtcgagg tgccgtaaag     2340

cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga aagccggcga     2400

acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg ctggcaagtg     2460

tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg ctacagggcg     2520

cgtactatgg ttgctttgac gtatgcggtg tgaaataccg cacagatgcg taaggagaaa     2580

ataccgcatc aggcgcccct gcaggcagct gcgcgctcgc tcgctcactg aggccgcccg     2640

ggcaaagccc gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg     2700

cagagaggga gtggccaact ccatcactag gggttcctgc ggccgctcgg tccgcacgtg     2760

agatctcatg cctgctattg tcttcccaat cctccccctt gctgtcctgc cccaccccac     2820

cccccagaat agaatgacac ctactcagac aatgcgatgc aatttcctca ttttattagg     2880

aaaggacagt gggagtggca ccttccaggg tcaaggaagg cacgggggag gggcaaacaa     2940

cagatggctg gcaactagaa ggcacagtcg aagatctctc gagccacgga attgtcagtg     3000

cccaacagcc gagcccctgt ccagcagcgg gcaaggcagg cggcgatgag ttccgccgtg     3060

gcaagaacta accaggattt atacaaggag gagaaaatga aagccatacg ggaagcaata     3120

gcatgataca aaggcattaa agcagcgtat ccacatagcg taaaaggagc aacatagtta     3180

agaataccag tcaatctttc acaaattttg taatccagag gttgattatg atatcgaatt     3240

cgcggccgcg gcgcgccgtc gacttacttg tacagctcgt ccatgccgag agtgatcccg     3300

gcggcggtca cgaactccag caggaccatg tgatcgcgct tctcgttggg gtctttgctc     3360

agcttggact ggtagctcag gtagtggttg tcgggcagca gcacggggcc gtcgccgatg     3420

ggggtgttct gctggtagtg gtcggcgagc tgcacgccgc cgtcctcgat gttgtggcgg     3480

atcttgaagt tggccttgat gccgttcttc tgcttgtcgg cggtgatata gacgttgtgg     3540

ctgttgtagt tgtactccag cttgtgcccc aggatgttgc cgtcctcctt gaagtcgatg     3600

cccttcagct cgatgcggtt caccagggtg tcgccctcga acttcacctc ggcgcgggtc     3660

ttgtagttgc cgtcgtcctt gaagaagatg gtgcgctcct ggacgtagcc ttcgggcatg     3720

gcggacttga agaagtcgtg ctgcttcatg tggtcggggt agcgggcgaa gcactgcacg     3780

ccgtagccca gggtggtcac gagggtgggc cagggcacgg gcagcttgcc ggtggtgcag     3840

atcagcttca gggtcagctt gccgtaggtg gcatcgccct cgccctcgcc ggacacgctg     3900

aacttgtggc cgtttacgtc gccgtccagc tcgaccagga tgggcaccac cccggtgaac     3960

agctcctcgc ccttgctcac catggtggcg accggtagcg ctagcttcga aagatctgga     4020

tcccagaagc aaatgtaagc aatagatggc tctgccctga cttttatgcc cagcccgagc     4080

tccattctct taaatgcagc cataattaga gtaatttttc atgtagcccg ctgattacag     4140

cgtttttacc gtcaaagata attacctgta attttcttcc acttttaata ctaaaaagcc     4200

atctttattt agccattctc ttaaatgcag ccataattag agtaattttt catgtagccc     4260

gctgattaca gcgtttttac cgtcaaagat aattacctgt aattttcttc cacttttaat     4320

actaaaaagc catctttatt tagccattct cttaaatgca gccataatta gagtaatttt     4380

tcatgtagcc cgctgattac agcgttttta ccgtcaaaga taattacctg taattttctt     4440

ccacttttaa tactaaaaag ccatctttat ttagggtacc acgcgtgcgg ccgcaggaac     4500

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     4560

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     4620

gcagctgcct gcagg                                                      4635


<210>  97
<211>  4841
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV: hI56i-minBglobin-SYFP2-WPRE3-BGHpA bottom strand

<400>  97
ctagatctcg agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat       60

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc      120

taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga      180

aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt      240

attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg      300

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac      360

gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg      420

ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca      480

agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc      540

tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc      600

ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag      660

gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc      720

ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca      780

gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg      840

aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg      900

aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct      960

ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa     1020

gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa     1080

gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa     1140

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc     1200

ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga     1260

ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca     1320

atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc     1380

ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat     1440

tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc     1500

attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt     1560

tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc     1620

ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg     1680

gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt     1740

gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg     1800

gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga     1860

aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg     1920

taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg     1980

tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt     2040

tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc     2100

atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca     2160

tttccccgaa aagtgccacc tgacgtctaa gaaaccatta ttatcatgac attaacctat     2220

aaaaataggc gtatcacgag gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac     2280

ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc     2340

agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggctg gcttaactat     2400

gcggcatcag agcagattgt actgagagtg caccatatgc ggtgtgaaat accgcacaga     2460

tgcgtaagga gaaaataccg catcaggcgc cattcgccat tcaggctgcg caactgttgg     2520

gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg gggatgtgct     2580

gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg taaaacgacg     2640

gccagtgaat tgtcgacgca tgcgggcccg gatctgtccc tctctgcgcg ctcgctcgct     2700

cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt     2760

gagcgagcga gcgcgcagag agggagtgga ctagtcatgc ctgctattgt cttcccaatc     2820

ctcccccttg ctgtcctgcc ccaccccacc ccccagaata gaatgacacc tactcagaca     2880

atgcgatgca atttcctcat tttattagga aaggacagtg ggagtggcac cttccagggt     2940

caaggaaggc acgggggagg ggcaaacaac agatggctgg caactagaag gcacagtcgc     3000

tcgagccacg gaattgtcag tgcccaacag ccgagcccct gtccagcagc gggcaaggca     3060

ggcggcgatg agttccgccg tggcaagaac taaccaggat ttatacaagg aggagaaaat     3120

gaaagccata cgggaagcaa tagcatgata caaaggcatt aaagcagcgt atccacatag     3180

cgtaaaagga gcaacatagt taagaatacc agtcaatctt tcacaaattt tgtaatccag     3240

aggttgatta tgatatcgaa ttcgcggccg cggcgcgccg tcgacttact tgtacagctc     3300

gtccatgccg agagtgatcc cggcggcggt cacgaactcc agcaggacca tgtgatcgcg     3360

cttctcgttg gggtctttgc tcagcttgga ctggtagctc aggtagtggt tgtcgggcag     3420

cagcacgggg ccgtcgccga tgggggtgtt ctgctggtag tggtcggcga gctgcacgcc     3480

gccgtcctcg atgttgtggc ggatcttgaa gttggccttg atgccgttct tctgcttgtc     3540

ggcggtgata tagacgttgt ggctgttgta gttgtactcc agcttgtgcc ccaggatgtt     3600

gccgtcctcc ttgaagtcga tgcccttcag ctcgatgcgg ttcaccaggg tgtcgccctc     3660

gaacttcacc tcggcgcggg tcttgtagtt gccgtcgtcc ttgaagaaga tggtgcgctc     3720

ctggacgtag ccttcgggca tggcggactt gaagaagtcg tgctgcttca tgtggtcggg     3780

gtagcgggcg aagcactgca cgccgtagcc cagggtggtc acgagggtgg gccagggcac     3840

gggcagcttg ccggtggtgc agatcagctt cagggtcagc ttgccgtagg tggcatcgcc     3900

ctcgccctcg ccggacacgc tgaacttgtg gccgtttacg tcgccgtcca gctcgaccag     3960

gatgggcacc accccggtga acagctcctc gcccttgctc accatggtgg cgaccggtag     4020

cgctagcttc gaaagatctg gatcccagaa gcaaatgtaa gcaatagatg gctctgccct     4080

gacttttatg cccagcccga gctccctact gtgaaacttt gggttcgtag ctccccagga     4140

tcaattctga acaaagcctc cagctgcagt gccatccaat ttgaagcaga cattggggac     4200

aatttaaggt ttttatccac aagaaggttt ttttccattc tcttaaatgc agccataatt     4260

agagtaattt ttcatgtagc ccgctgatta cagcgttttt accgtcaaag ataattacct     4320

gtaattttct tccactttta atactaaaaa gccatcttta tttagattca ggaacaggaa     4380

aggcgaaaca aaagagggaa attattctgt tattcataca caaattgcag agacgtagga     4440

cctaaaattg aaaattaacc aaaattataa tgctgaaaag aatggaagag gctgcagaag     4500

tacagctggt agtggggctt tgctgaatta ttcaaattac gttagggaga atgctaccat     4560

acatcgaaac caacactaat ttttcgttaa aaaaaattca ccagatgcat gccaaaccac     4620

tgtgagtgca tagagctcgg tacctatacg cgtcctaggt cacgactcca cccctccagg     4680

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     4740

cccgggcaaa gcccgggcgt cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag     4800

cgcgcagaga gggagtggcc cagatccccc cgggaagctt t                         4841


<210>  98
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence changed in AAV9

<400>  98

Ser Ala Gln Ala 
1               


<210>  99
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GCaMP6m

<400>  99
atgggttctc atcatcatca tcatcatggt atggctagca tgactggtgg acagcaaatg       60

ggtcgggatc tgtacgacga tgacgataag gatctcgcca ccatggtcga ctcatcacgt      120

cgtaagtgga ataagacagg tcacgcagtc agagctatag gtcggctgag ctcactcgag      180

aacgtctata tcaaggccga caagcagaag aacggcatca aggcgaactt caagatccgc      240

cacaacatcg aggacggcgg cgtgcagctc gcctaccact accagcagaa cacccccatc      300

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcgtgcagtc caaactttcg      360

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg      420

atcactctcg gcatggacga gctgtacaag ggcggtaccg gagggagcat ggtgagcaag      480

ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac      540

ggccacaagt tcagcgtgtc cggcgagggt gagggcgatg ccacctacgg caagctgacc      600

ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc      660

ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc      720

ttcaagtccg ccatgcccga aggctacatc caggagcgca ccatcttctt caaggacgac      780

ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc      840

gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac      900

aacctgccgg accaactgac tgaagagcag atcgcagaat ttaaagaggc tttctcccta      960

tttgacaagg acggggatgg gacaataaca accaaggagc tggggacggt gatgcggtct     1020

ctggggcaga accccacaga agcagagctg caggacatga tcaatgaagt agatgccgac     1080

ggtgacggca caatcgactt ccctgagttc ctgacaatga tggcaagaaa agggagctac     1140

agggacacgg aagaagaaat tagagaagcg ttcggtgtgt ttgataagga tggcaatggc     1200

tacatcagtg cagcagagct tcgccacgtg atgacaaacc ttggagagaa gttaacagat     1260

gaagaggttg atgaaatgat cagggaagca gacatcgatg gggatggtca ggtaaactac     1320

gaagagtttg tacaaatgat gacagcgaag tga                                  1353


<210>  100
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GCaMP6s

<400>  100
atgggttctc atcatcatca tcatcatggt atggctagca tgactggtgg acagcaaatg       60

ggtcgggatc tgtacgacga tgacgataag gatctcgcca ccatggtcga ctcatcacgt      120

cgtaagtgga ataagacagg tcacgcagtc agagctatag gtcggctgag ctcactcgag      180

aacgtctata tcaaggccga caagcagaag aacggcatca aggcgaactt ccacatccgc      240

cacaacatcg aggacggcgg cgtgcagctc gcctaccact accagcagaa cacccccatc      300

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcgtgcagtc caaactttcg      360

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg      420

atcactctcg gcatggacga gctgtacaag ggcggtaccg gagggagcat ggtgagcaag      480

ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac      540

ggccacaagt tcagcgtgtc cggcgagggt gagggcgatg ccacctacgg caagctgacc      600

ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc      660

ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc      720

ttcaagtccg ccatgcccga aggctacatc caggagcgca ccatcttctt caaggacgac      780

ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc      840

gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac      900

aacctgccgg accaactgac tgaagagcag atcgcagaat ttaaagaggc tttctcccta      960

tttgacaagg acggggatgg gacaataaca accaaggagc tggggacggt gatgcggtct     1020

ctggggcaga accccacaga agcagagctg caggacatga tcaatgaagt agatgccgac     1080

ggtgacggca caatcgactt ccctgagttc ctgacaatga tggcaagaaa aatgaaatac     1140

agggacacgg aagaagaaat tagagaagcg ttcggtgtgt ttgataagga tggcaatggc     1200

tacatcagtg cagcagagct tcgccacgtg atgacaaacc ttggagagaa gttaacagat     1260

gaagaggttg atgaaatgat cagggaagca gacatcgatg gggatggtca ggtaaactac     1320

gaagagtttg tacaaatgat gacagcgaag tga                                  1353


<210>  101
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GCaMP6f

<400>  101
atgggttctc atcatcatca tcatcatggt atggctagca tgactggtgg acagcaaatg       60

ggtcgggatc tgtacgacga tgacgataag gatctcgcca ccatggtcga ctcatcacgt      120

cgtaagtgga ataagacagg tcacgcagtc agagctatag gtcggctgag ctcactcgag      180

aacgtctata tcaaggccga caagcagaag aacggcatca aggcgaactt caagatccgc      240

cacaacatcg aggacggcgg cgtgcagctc gcctaccact accagcagaa cacccccatc      300

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcgtgcagtc caaactttcg      360

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg      420

atcactctcg gcatggacga gctgtacaag ggcggtaccg gagggagcat ggtgagcaag      480

ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac      540

ggccacaagt tcagcgtgtc cggcgagggt gagggcgatg ccacctacgg caagctgacc      600

ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc      660

ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc      720

ttcaagtccg ccatgcccga aggctacatc caggagcgca ccatcttctt caaggacgac      780

ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc      840

gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac      900

aacctgccgg accaactgac tgaagagcag atcgcagaat ttaaagagga attctcccta      960

tttgacaagg acggggatgg gacaataaca accaaggagc tggggacggt gatgcggtct     1020

ctggggcaga accccacaga agcagagctg caggacatga tcaatgaagt agatgccgac     1080

ggtgacggca caatcgactt ccctgagttc ctgacaatga tggcaagaaa aatgaaatac     1140

agggacacgg aagaagaaat tagagaagcg ttcggtgtgt ttgataagga tggcaatggc     1200

tacatcagtg cagcagagct tcgccacgtg atgacaaacc ttggagagaa gttaacagat     1260

gaagaggttg atgaaatgat cagggaagca gacatcgatg gggatggtca ggtaaactac     1320

gaagagtttg tacaaatgat gacagcgaag tga                                  1353


<210>  102
<211>  717
<212>  PRT
<213>  Chlamydomonas yellowstonensis

<400>  102

Met Asp Thr Leu Ala Trp Val Ala Arg Glu Leu Leu Ser Ser Gly His 
1               5                   10                  15      


Gly Thr Asp Thr Ala Thr Asp Ser Gly His Gly Thr Asp Thr Ser Gly 
            20                  25                  30          


Gly His Asp Ser Ser His Asp Ala Val Ala His Asn Val Thr Leu Leu 
        35                  40                  45              


Ile Ala Pro Pro His Ala Gly Gly His Ala Gly Pro Thr Asp Thr Ser 
    50                  55                  60                  


Gln Gln Ile Thr Gly Ile Asp Gly Trp Ile Ala Ile Pro Ala Gly Asp 
65                  70                  75                  80  


Cys Tyr Cys Ala Gly Trp Tyr Val Ser His Gly Ser Ser Phe Glu Ala 
                85                  90                  95      


Thr Phe Ala His Val Cys Gln Trp Ser Ile Phe Ala Val Cys Val Leu 
            100                 105                 110         


Ser Leu Leu Trp Tyr Ala Tyr Gln Tyr Trp Lys Ala Thr Cys Gly Trp 
        115                 120                 125             


Glu Glu Val Tyr Val Cys Cys Ile Glu Leu Val Phe Ile Cys Phe Glu 
    130                 135                 140                 


Leu Tyr His Glu Phe Asp Ser Pro Cys Ser Leu Tyr Leu Ser Thr Ser 
145                 150                 155                 160 


Asn Val Val Asn Trp Leu Arg Tyr Ser Glu Trp Leu Leu Cys Cys Pro 
                165                 170                 175     


Val Ile Leu Ile His Leu Ser Asn Val Thr Gly Leu Ser Asp Asp Tyr 
            180                 185                 190         


Gly Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Ala Thr Ile Val 
        195                 200                 205             


Phe Gly Val Thr Ala Ala Met Leu Val Asn Trp Pro Lys Ile Ile Phe 
    210                 215                 220                 


Tyr Leu Ile Gly Phe Thr Met Cys Cys Tyr Thr Phe Phe Leu Ala Ala 
225                 230                 235                 240 


Lys Val Leu Ile Glu Ser Phe His Gln Val Pro Lys Gly Ile Cys Arg 
                245                 250                 255     


His Leu Val Lys Ala Met Ala Ile Thr Tyr Phe Val Gly Trp Ser Phe 
            260                 265                 270         


Phe Pro Leu Ile Phe Leu Phe Gly Gln Ser Gly Phe Lys Lys Ile Ser 
        275                 280                 285             


Pro Tyr Ala Asp Val Ile Ala Ser Ser Phe Gly Asp Leu Ile Ser Lys 
    290                 295                 300                 


Asn Ala Phe Gly Met Leu Gly His Phe Leu Arg Val Lys Ile His Glu 
305                 310                 315                 320 


His Ile Leu Lys His Gly Asp Ile Arg Lys Thr Thr His Leu Arg Ile 
                325                 330                 335     


Ala Gly Glu Glu Lys Glu Val Glu Thr Phe Val Glu Glu Glu Asp Glu 
            340                 345                 350         


Asp Thr Ala Lys His Ser Thr Lys Glu Leu Ala Asn Arg Gly Ser Phe 
        355                 360                 365             


Ile Val Met Arg Asp Lys Met Lys Glu Gln Gly Ile Asp Val Arg Ala 
    370                 375                 380                 


Ser Leu Asp Met Asp Glu Asp Glu Glu Ala Arg Thr Gly Lys Gly Lys 
385                 390                 395                 400 


Gly Ala Gly Ala Thr Ser Leu Val Pro Gly Arg Val Ile Leu Ala Val 
                405                 410                 415     


Pro Asp Ile Ser Met Val Asp Phe Phe His Asp His Phe Ala His Leu 
            420                 425                 430         


Gly Ala Ser Ile Glu Leu Val Pro Ala Leu Gly Val Glu Asn Thr Leu 
        435                 440                 445             


Leu Leu Val Gln Gln Ala Met Gln Leu Gly Gly Leu Asp Phe Val Leu 
    450                 455                 460                 


Val His Pro Glu Phe Leu Arg Asp Arg Ser Gln Asn Gly Leu Val Ser 
465                 470                 475                 480 


Arg Leu Lys Met Thr Gly His Gly Val Cys Ala Phe Gly Trp Val Pro 
                485                 490                 495     


Ser Gly Pro Met Arg Glu Ile Ile Glu Ser Ala Gly Val Asp Gly Trp 
            500                 505                 510         


Leu Asp Gly Pro Ser Phe Gly Thr Gly Ile Asp Gln Glu Gln Leu Ile 
        515                 520                 525             


Glu Leu Ile Gly Tyr Met Gln Ala Lys Arg Lys Phe Gly Met Arg Phe 
    530                 535                 540                 


Gly Gly Gly Gly Ala Ser Lys Ala Gly Tyr Ser Ser Asp Gly Gly Phe 
545                 550                 555                 560 


Gly Gly Lys Gly Met Leu Glu Met Gln Pro Ser Met Ser Gln Gly Ser 
                565                 570                 575     


Gly Val Pro Leu Leu Gln Gln Asn Asn Ser Met Met Arg Ala Pro Pro 
            580                 585                 590         


Ser Pro Met Gly Asn Met Ala Asn Asn Gly Met Met Asn Pro Met Met 
        595                 600                 605             


Ser Met Asn Asn Pro Met Met Gly Gly Gly Ala Val Met Met Thr Ser 
    610                 615                 620                 


Met Gly Ser Met Gln Gln Ala Ala Asn Pro Leu Tyr Gly Ala Pro Pro 
625                 630                 635                 640 


Ser Pro Leu Ser Ser Gln Pro Gly Ala Gly Met Tyr Gly Ala Pro Ala 
                645                 650                 655     


Gln Pro Gln Met Gly Ser Gln Gly Ser Met His Gly Ser Met Tyr Gly 
            660                 665                 670         


Gly Ser Gln Gln Gln His Gln Gln Pro Gln Gln Ala Ala Ala Ala Pro 
        675                 680                 685             


Ala Ala Ala Asp Gly Gly Ser Glu Ala Glu Met Leu Lys Gln Leu Met 
    690                 695                 700                 


Ser Glu Ile Asn Arg Leu Lys Ala Glu Leu Gly Glu Ser 
705                 710                 715         


<210>  103
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct of Channel rhodopsin 2

<400>  103

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  104
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Ala Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Glu  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  105
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Val Gln Lys Ser Arg Asn Gly Gly Val Tyr Pro Gly Pro Ser Gly 
1               5                   10                  15      


Glu Lys Lys Leu Lys Val Gly Phe Val Gly Leu Asp Pro Gly Ala Pro 
            20                  25                  30          


Asp Ser Thr Arg Asp Gly Ala Leu Leu Ile Ala Gly Ser Glu Ala Pro 
        35                  40                  45              


Lys Arg Gly Ser Ile Leu Ser Lys Pro Arg Ala Gly Gly Ala Gly Ala 
    50                  55                  60                  


Gly Lys Pro Pro Lys Arg Asn Ala Phe Tyr Arg Lys Leu Gln Asn Phe 
65                  70                  75                  80  


Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile Tyr His 
                85                  90                  95      


Ala Tyr Val Phe Leu Leu Val Phe Ser Cys Leu Val Leu Ser Val Phe 
            100                 105                 110         


Ser Thr Ile Lys Glu Tyr Glu Lys Ser Ser Glu Gly Ala Leu Tyr Ile 
        115                 120                 125             


Leu Glu Ile Val Thr Ile Val Val Phe Gly Val Glu Tyr Phe Val Arg 
    130                 135                 140                 


Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Arg Gly Arg 
145                 150                 155                 160 


Leu Lys Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Ile Met Val Leu 
                165                 170                 175     


Ile Ala Ser Ile Ala Val Leu Ala Ala Gly Ser Gln Gly Asn Val Phe 
            180                 185                 190         


Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met 
        195                 200                 205             


Ile Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Val 
    210                 215                 220                 


Val Tyr Ala His Ser Lys Glu Leu Val Thr Ala Trp Tyr Ile Gly Phe 
225                 230                 235                 240 


Leu Cys Leu Ile Leu Ala Ser Phe Leu Val Tyr Leu Ala Glu Lys Gly 
                245                 250                 255     


Glu Asn Asp His Phe Asp Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu 
            260                 265                 270         


Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Tyr Pro Gln Thr Trp 
        275                 280                 285             


Asn Gly Arg Leu Leu Ala Ala Thr Phe Thr Leu Ile Gly Val Ser Phe 
    290                 295                 300                 


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
305                 310                 315                 320 


Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn Pro Ala 
                325                 330                 335     


Ala Gly Leu Ile Gln Ser Ala Trp Arg Phe Tyr Ala Thr Asn Leu Ser 
            340                 345                 350         


Arg Thr Asp Leu His Ser Thr Trp Gln Tyr Tyr Glu Arg Thr Val Thr 
        355                 360                 365             


Val Pro Met Tyr Ser Ser Gln Thr Gln Thr Tyr Gly Ala Ser Arg Leu 
    370                 375                 380                 


Ile Pro Pro Leu Asn Gln Leu Glu Leu Leu Arg Asn Leu Lys Ser Lys 
385                 390                 395                 400 


Ser Gly Leu Ala Phe Arg Lys Asp Pro Pro Pro Glu Pro Ser Pro Ser 
                405                 410                 415     


Lys Gly Ser Pro Cys Arg Gly Pro Leu Cys Gly Cys Cys Pro Gly Arg 
            420                 425                 430         


Ser Ser Gln Lys Val Ser Leu Lys Asp Arg Val Phe Ser Ser Pro Arg 
        435                 440                 445             


Gly Val Ala Ala Lys Gly Lys Gly Ser Pro Gln Ala Gln Thr Val Arg 
    450                 455                 460                 


Arg Ser Pro Ser Ala Asp Gln Ser Leu Glu Asp Ser Pro Ser Lys Val 
465                 470                 475                 480 


Pro Lys Ser Trp Ser Phe Gly Asp Arg Ser Arg Ala Arg Gln Ala Phe 
                485                 490                 495     


Arg Ile Lys Gly Ala Ala Ser Arg Gln Asn Ser Glu Glu Ala Ser Leu 
            500                 505                 510         


Pro Gly Glu Asp Ile Val Asp Asp Lys Ser Cys Pro Cys Glu Phe Val 
        515                 520                 525             


Thr Glu Asp Leu Thr Pro Gly Leu Lys Val Ser Ile Arg Ala Val Cys 
    530                 535                 540                 


Val Met Arg Phe Leu Val Ser Lys Arg Lys Phe Lys Glu Ser Leu Arg 
545                 550                 555                 560 


Pro Tyr Asp Val Met Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu 
                565                 570                 575     


Asp Met Leu Ser Arg Ile Lys Ser Leu Gln Ser Arg Val Asp Gln Ile 
            580                 585                 590         


Val Gly Arg Gly Pro Ala Ile Thr Asp Lys Asp Arg Thr Lys Gly Pro 
        595                 600                 605             


Ala Glu Ala Glu Leu Pro Glu Asp Pro Ser Met Met Gly Arg Leu Gly 
    610                 615                 620                 


Lys Val Glu Lys Gln Val Leu Ser Met Glu Lys Lys Leu Asp Phe Leu 
625                 630                 635                 640 


Val Asn Ile Tyr Met Gln Arg Met Gly Ile Pro Pro Thr Glu Thr Glu 
                645                 650                 655     


Ala Tyr Phe Gly Ala Lys Glu Pro Glu Pro Ala Pro Pro Tyr His Ser 
            660                 665                 670         


Pro Glu Asp Ser Arg Glu His Val Asp Arg His Gly Cys Ile Val Lys 
        675                 680                 685             


Ile Val Arg Ser Ser Ser Ser Thr Gly Gln Lys Asn Phe Ser Ala Pro 
    690                 695                 700                 


Pro Ala Ala Pro Pro Val Gln Cys Pro Pro Ser Thr Ser Trp Gln Pro 
705                 710                 715                 720 


Gln Ser His Pro Arg Gln Gly His Gly Thr Ser Pro Val Gly Asp His 
                725                 730                 735     


Gly Ser Leu Val Arg Ile Pro Pro Pro Pro Ala His Glu Arg Ser Leu 
            740                 745                 750         


Ser Ala Tyr Gly Gly Gly Asn Arg Ala Ser Met Glu Phe Leu Arg Gln 
        755                 760                 765             


Glu Asp Thr Pro Gly Cys Arg Pro Pro Glu Gly Asn Leu Arg Asp Ser 
    770                 775                 780                 


Asp Thr Ser Ile Ser Ile Pro Ser Val Asp His Glu Glu Leu Glu Arg 
785                 790                 795                 800 


Ser Phe Ser Gly Phe Ser Ile Ser Gln Ser Lys Glu Asn Leu Asp Ala 
                805                 810                 815     


Leu Asn Ser Cys Tyr Ala Ala Val Ala Pro Cys Ala Lys Val Arg Pro 
            820                 825                 830         


Tyr Ile Ala Glu Gly Glu Ser Asp Thr Asp Ser Asp Leu Cys Thr Pro 
        835                 840                 845             


Cys Gly Pro Pro Pro Arg Ser Ala Thr Gly Glu Gly Pro Phe Gly Asp 
    850                 855                 860                 


Val Gly Trp Ala Gly Pro Arg Lys 
865                 870         


<210>  106
<211>  2221
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Ile Leu Gly Asn Ala Asp Tyr Val Phe 
945                 950                 955                 960 


Thr Ser Ile Phe Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly 
                965                 970                 975     


Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu 
            980                 985                 990         


Asp Leu Leu Val Val Ser Val Ser  Leu Ile Ser Phe Gly  Ile Gln Ser 
        995                 1000                 1005             


Ser Ala  Ile Asn Val Val Lys  Ile Leu Arg Val Leu  Arg Val Leu 
    1010                 1015                 1020             


Arg Pro  Leu Arg Ala Ile Asn  Arg Ala Lys Gly Leu  Lys His Val 
    1025                 1030                 1035             


Val Gln  Cys Val Phe Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val 
    1040                 1045                 1050             


Ile Val  Thr Thr Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
    1055                 1060                 1065             


Gln Leu  Phe Lys Gly Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys 
    1070                 1075                 1080             


Gln Thr  Glu Ala Glu Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp 
    1085                 1090                 1095             


Gly Glu  Val Asp His Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn 
    1100                 1105                 1110             


Ser Lys  Phe Asp Phe Asp Asn  Val Leu Ala Ala Met  Met Ala Leu 
    1115                 1120                 1125             


Phe Thr  Val Ser Thr Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg 
    1130                 1135                 1140             


Ser Ile  Asp Ser His Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr 
    1145                 1150                 1155             


Arg Val  Glu Ile Ser Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile 
    1160                 1165                 1170             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Val Thr 
    1175                 1180                 1185             


Phe Gln  Glu Gln Gly Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp 
    1190                 1195                 1200             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro 
    1205                 1210                 1215             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp 
    1220                 1225                 1230             


Tyr Val  Val Asn Ser Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu 
    1235                 1240                 1245             


Ile Leu  Leu Asn Thr Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln 
    1250                 1255                 1260             


Ser Cys  Leu Phe Lys Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe 
    1265                 1270                 1275             


Thr Gly  Leu Phe Thr Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe 
    1280                 1285                 1290             


Lys Pro  Lys Gly Tyr Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe 
    1295                 1300                 1305             


Leu Ile  Val Ile Gly Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr 
    1310                 1315                 1320             


Asn His  Tyr Phe Cys Asp Ala  Trp Asn Thr Phe Asp  Ala Leu Ile 
    1325                 1330                 1335             


Val Val  Gly Ser Ile Val Asp  Ile Ala Ile Thr Glu  Val Asn Pro 
    1340                 1345                 1350             


Ala Glu  His Thr Gln Cys Ser  Pro Ser Met Asn Ala  Glu Glu Asn 
    1355                 1360                 1365             


Ser Arg  Ile Ser Ile Thr Phe  Phe Arg Leu Phe Arg  Val Met Arg 
    1370                 1375                 1380             


Leu Val  Lys Leu Leu Ser Arg  Gly Glu Gly Ile Arg  Thr Leu Leu 
    1385                 1390                 1395             


Trp Thr  Phe Ile Lys Ser Phe  Gln Ala Leu Pro Tyr  Val Ala Leu 
    1400                 1405                 1410             


Leu Ile  Val Met Leu Phe Phe  Ile Tyr Ala Val Ile  Gly Met Gln 
    1415                 1420                 1425             


Val Phe  Gly Lys Ile Ala Leu  Asn Asp Thr Thr Glu  Ile Asn Arg 
    1430                 1435                 1440             


Asn Asn  Asn Phe Gln Thr Phe  Pro Gln Ala Val Leu  Leu Leu Phe 
    1445                 1450                 1455             


Arg Cys  Ala Thr Gly Glu Ala  Trp Gln Asp Ile Met  Leu Ala Cys 
    1460                 1465                 1470             


Met Pro  Gly Lys Lys Cys Ala  Pro Glu Ser Glu Pro  Ser Asn Ser 
    1475                 1480                 1485             


Thr Glu  Gly Glu Thr Pro Cys  Gly Ser Ser Phe Ala  Val Phe Tyr 
    1490                 1495                 1500             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1505                 1510                 1515             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1520                 1525                 1530             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1535                 1540                 1545             


Trp Ala  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1550                 1555                 1560             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1565                 1570                 1575             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ser 
    1580                 1585                 1590             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1595                 1600                 1605             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Arg Ile  Lys Thr Glu 
    1610                 1615                 1620             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Ile Ile Lys 
    1625                 1630                 1635             


Lys Ile  Trp Lys Arg Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1640                 1645                 1650             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1655                 1660                 1665             


Thr Phe  Leu Ile Gln Glu Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1670                 1675                 1680             


Glu Gln  Gly Leu Val Gly Lys  Pro Ser Gln Arg Asn  Ala Leu Ser 
    1685                 1690                 1695             


Leu Gln  Ala Gly Leu Arg Thr  Leu His Asp Ile Gly  Pro Glu Ile 
    1700                 1705                 1710             


Arg Arg  Ala Ile Ser Gly Asp  Leu Thr Ala Glu Glu  Glu Leu Asp 
    1715                 1720                 1725             


Lys Ala  Met Lys Glu Ala Val  Ser Ala Ala Ser Glu  Asp Asp Ile 
    1730                 1735                 1740             


Phe Arg  Arg Ala Gly Gly Leu  Phe Gly Asn His Val  Ser Tyr Tyr 
    1745                 1750                 1755             


Gln Ser  Asp Gly Arg Ser Ala  Phe Pro Gln Thr Phe  Thr Thr Gln 
    1760                 1765                 1770             


Arg Pro  Leu His Ile Asn Lys  Ala Gly Ser Ser Gln  Gly Asp Thr 
    1775                 1780                 1785             


Glu Ser  Pro Ser His Glu Lys  Leu Val Asp Ser Thr  Phe Thr Pro 
    1790                 1795                 1800             


Ser Ser  Tyr Ser Ser Thr Gly  Ser Asn Ala Asn Ile  Asn Asn Ala 
    1805                 1810                 1815             


Asn Asn  Thr Ala Leu Gly Arg  Leu Pro Arg Pro Ala  Gly Tyr Pro 
    1820                 1825                 1830             


Ser Thr  Val Ser Thr Val Glu  Gly His Gly Pro Pro  Leu Ser Pro 
    1835                 1840                 1845             


Ala Ile  Arg Val Gln Glu Val  Ala Trp Lys Leu Ser  Ser Asn Arg 
    1850                 1855                 1860             


Glu Arg  His Val Pro Met Cys  Glu Asp Leu Glu Leu  Arg Arg Asp 
    1865                 1870                 1875             


Ser Gly  Ser Ala Gly Thr Gln  Ala His Cys Leu Leu  Leu Arg Lys 
    1880                 1885                 1890             


Ala Asn  Pro Ser Arg Cys His  Ser Arg Glu Ser Gln  Ala Ala Met 
    1895                 1900                 1905             


Ala Gly  Gln Glu Glu Thr Ser  Gln Asp Glu Thr Tyr  Glu Val Lys 
    1910                 1915                 1920             


Met Asn  His Asp Thr Glu Ala  Cys Ser Glu Pro Ser  Leu Leu Ser 
    1925                 1930                 1935             


Thr Glu  Met Leu Ser Tyr Gln  Asp Asp Glu Asn Arg  Gln Leu Thr 
    1940                 1945                 1950             


Leu Pro  Glu Glu Asp Lys Arg  Asp Ile Arg Gln Ser  Pro Lys Arg 
    1955                 1960                 1965             


Gly Phe  Leu Arg Ser Ala Ser  Leu Gly Arg Arg Ala  Ser Phe His 
    1970                 1975                 1980             


Leu Glu  Cys Leu Lys Arg Gln  Lys Asp Arg Gly Gly  Asp Ile Ser 
    1985                 1990                 1995             


Gln Lys  Thr Val Leu Pro Leu  His Leu Val His His  Gln Ala Leu 
    2000                 2005                 2010             


Ala Val  Ala Gly Leu Ser Pro  Leu Leu Gln Arg Ser  His Ser Pro 
    2015                 2020                 2025             


Ala Ser  Phe Pro Arg Pro Phe  Ala Thr Pro Pro Ala  Thr Pro Gly 
    2030                 2035                 2040             


Ser Arg  Gly Trp Pro Pro Gln  Pro Val Pro Thr Leu  Arg Leu Glu 
    2045                 2050                 2055             


Gly Val  Glu Ser Ser Glu Lys  Leu Asn Ser Ser Phe  Pro Ser Ile 
    2060                 2065                 2070             


His Cys  Gly Ser Trp Ala Glu  Thr Thr Pro Gly Gly  Gly Gly Ser 
    2075                 2080                 2085             


Ser Ala  Ala Arg Arg Val Arg  Pro Val Ser Leu Met  Val Pro Ser 
    2090                 2095                 2100             


Gln Ala  Gly Ala Pro Gly Arg  Gln Phe His Gly Ser  Ala Ser Ser 
    2105                 2110                 2115             


Leu Val  Glu Ala Val Leu Ile  Ser Glu Gly Leu Gly  Gln Phe Ala 
    2120                 2125                 2130             


Gln Asp  Pro Lys Phe Ile Glu  Val Thr Thr Gln Glu  Leu Ala Asp 
    2135                 2140                 2145             


Ala Cys  Asp Met Thr Ile Glu  Glu Met Glu Ser Ala  Ala Asp Asn 
    2150                 2155                 2160             


Ile Leu  Ser Gly Gly Ala Pro  Gln Ser Pro Asn Gly  Ala Leu Leu 
    2165                 2170                 2175             


Pro Phe  Val Asn Cys Arg Asp  Ala Gly Gln Asp Arg  Ala Gly Gly 
    2180                 2185                 2190             


Glu Glu  Asp Ala Gly Cys Val  Arg Ala Arg Gly Arg  Pro Ser Glu 
    2195                 2200                 2205             


Glu Glu  Leu Gln Asp Ser Arg  Val Tyr Val Ser Ser  Leu 
    2210                 2215                 2220     


