                         SEQUENCE LISTING

<110>  Universit degli Studi di Palermo
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
       Universit Telematica eCampus
       SORBONNE UNIVERSITE
       Universit degli Studi di Roma "La Sapienza"
       INSERM INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE 
       MEDICALE
       Di Felice , Valentina
 
<120>  Process for the synthesis of exosomes containing heat shock 
       proteins and their use for the treatment of muscular atrophy and 
       cachexia

<130>  RBW15508-PCT

<150>  102018000009235
<151>  2018-10-08

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Arg Leu Pro Thr Val Leu Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Ala Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
            20                  25                  30          


Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
        35                  40                  45              


Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
    50                  55                  60                  


Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                85                  90                  95      


Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
            100                 105                 110         


Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
        115                 120                 125             


Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
    130                 135                 140                 


Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
145                 150                 155                 160 


Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                165                 170                 175     


Asn Gly Asp Lys Asp Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
            180                 185                 190         


Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
        195                 200                 205             


Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
    210                 215                 220                 


Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
225                 230                 235                 240 


Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Val Gln Ser 
                245                 250                 255     


Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
            260                 265                 270         


Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
        275                 280                 285             


Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
    290                 295                 300                 


Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
305                 310                 315                 320 


Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Asn Leu Asn Leu Glu Asp 
                325                 330                 335     


Val Gln Ala His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
            340                 345                 350         


Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala His Ile Glu 
        355                 360                 365             


Lys Arg Ile Gln Glu Ile Thr Glu Gln Leu Asp Ile Thr Thr Ser Glu 
    370                 375                 380                 


Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
385                 390                 395                 400 


Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                405                 410                 415     


Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
            420                 425                 430         


Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
        435                 440                 445             


Pro Ala Leu Asp Ser Leu Lys Pro Ala Asn Glu Asp Gln Lys Ile Gly 
    450                 455                 460                 


Ile Glu Ile Ile Lys Arg Ala Leu Lys Ile Pro Ala Met Thr Ile Ala 
465                 470                 475                 480 


Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Leu Gln 
                485                 490                 495     


Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Leu Gly Asp Phe Val Asn 
            500                 505                 510         


Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
        515                 520                 525             


Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Ala 
    530                 535                 540                 


Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
545                 550                 555                 560 


Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                565                 570             


<210>  2
<211>  84
<212>  DNA
<213>  Synthetic

<400>  2
acgcggccgc tcgagcagaa actcatctca gaagaggatc tggcagcaaa tgatatcctg       60

gattacaagg atgacgacga taag                                              84


<210>  3
<211>  6600
<212>  DNA
<213>  Synthetic

<400>  3
aacaaaatat taacgcttac aatttccatt cgccattcag gctgcgcaac tgttgggaag       60

ggcgatcggt gcgggcctct tcgctattac gccagctggc gaaaggggga tgtgctgcaa      120

ggcgattaag ttgggtaacg ccagggtttt cccagtcacg acgttgtaaa acgacggcca      180

gtgccaagct gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt      240

atatagcata aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata      300

tgtacattta tattggctca tgtccaatat gaccgccatg ttgacattga ttattgacta      360

gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg      420

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga      480

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat      540

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa      600

gtccgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca      660

tgaccttacg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca      720

tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat      780

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg      840

actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac      900

ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagaatttt gtaatacgac      960

tcactatagg gcggccggga attcgtcgac tggatccggt accgaggaga tctgccgccg     1020

cgatcgccat gcttcgacta cccacagtcc ttcgccagat gagaccagtg tcccgggcac     1080

tggctcctca tctcactcgg gcctatgcca aagatgtaaa atttggtgcg gacgctcgag     1140

ccttaatgct tcaaggtgta gaccttttag cagatgctgt agctgttaca atggggccaa     1200

agggaagaac tgtgattatt gaacagagtt ggggaagtcc caaagtaaca aaagatgggg     1260

tcactgttgc aaagtcaatt gatttaaagg ataaatacaa aaatattgga gctaaacttg     1320

ttcaggacgt tgccaataac acaaacgaag aggctgggga tggcaccacc actgccactg     1380

ttctggcacg atctattgcc aaggagggct ttgagaagat cagcaaaggg gctaatccag     1440

tggaaatccg gagaggtgtg atgttggctg tggatgctgt aattgctgaa cttaagaaac     1500

agtctaaacc tgtgacaacc cctgaagaaa ttgctcaggt tgctacaatt tctgcaaatg     1560

gagacaaaga cattgggaac atcatttctg atgcaatgaa aaaggttgga agaaagggtg     1620

tcatcacagt gaaggatgga aaaaccctga atgatgagct agaaattatt gaaggcatga     1680

agtttgatag aggatatatt tccccgtatt ttattaacac atcaaaaggt caaaagtgtg     1740

aattccaaga tgcctatgtc ttgttgagtg aaaagaaaat ttccagtgtt cagtccattg     1800

tccctgctct tgaaattgct aatgctcatc ggaagccatt ggtcataatc gccgaagacg     1860

ttgacggaga agctctaagc acgctggttt tgaacaggct aaaagttggt cttcaggttg     1920

tggcagtcaa agctccagga tttggggaca ataggaagaa ccagcttaaa gatatggcta     1980

ttgctactgg tggtgcagtg tttggagaag aggggttgaa tctaaatctt gaagatgttc     2040

aagctcatga cttaggaaaa gttggggagg tcattgtcac caaagatgat gccatgcttt     2100

tgaaaggaaa aggtgacaaa gctcacattg aaaaacgtat tcaagaaatc actgagcagc     2160

tagacatcac aactagtgaa tatgaaaaag aaaagctgaa cgagcgactt gctaaacttt     2220

cagatggagt agctgtgttg aaggttggag gaacaagtga tgttgaagtg aatgagaaaa     2280

aagacagagt tactgatgct ctcaatgcta caagagcagc tgttgaagaa ggcattgttc     2340

taggaggggg ctgcgctctg cttcggtgca tcccagcctt ggattcatta aagcctgcta     2400

atgaagacca gaaaataggt atagaaatta ttaaaagagc acttaaaatt cctgcaatga     2460

cgattgctaa gaatgcaggt gttgaaggat ctttgatagt tgagaaaatt ctgcagagtt     2520

cctcagaagt tggttatgac gccatgcttg gagattttgt gaacatggtg gaaaaaggga     2580

tcattgatcc aacaaaggtt gtgagaactg ccttactgga tgctgctggg gtggcctcct     2640

tgctaactac agccgaagct gtagtgacag aaattcctaa agaagagaag gaccctggaa     2700

tgggtgcaat gggtggcatg ggagggggta tgggaggcgg catgttcacg cgtacgcggc     2760

cgctcgagca gaaactcatc tcagaagagg atctggcagc aaatgatatc ctggattaca     2820

aggatgacga cgataaggtt taaacggccg gccgcggtca tagctgtttc ctgaacagat     2880

cccgggtggc atccctgtga cccctcccca gtgcctctcc tggccctgga agttgccact     2940

ccagtgccca ccagccttgt cctaataaaa ttaagttgca tcattttgtc tgactaggtg     3000

tccttctata atattatggg gtggaggggg gtggtatgga gcaaggggca agttgggaag     3060

acaacctgta gggcctgcgg ggtctattgg gaaccaagct ggagtgcagt ggcacaatct     3120

tggctcactg caatctccgc ctcctgggtt caagcgattc tcctgcctca gcctcccgag     3180

ttgttgggat tccaggcatg catgaccagg ctcagctaat ttttgttttt ttggtagaga     3240

cggggtttca ccatattggc caggctggtc tccaactcct aatctcaggt gatctaccca     3300

ccttggcctc ccaaattgct gggattacag gcgtgaacca ctgctccctt ccctgtcctt     3360

ctgattttaa aataactata ccagcaggag gacgtccaga cacagcatag gctacctggc     3420

catgcccaac cggtgggaca tttgagttgc ttgcttggca ctgtcctctc atgcgttggg     3480

tccactcagt agatgcctgt tgaattgggt acgcggccag cggcgagcgg tatcagctca     3540

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg     3600

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     3660

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     3720

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     3780

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     3840

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     3900

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     3960

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     4020

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     4080

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     4140

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     4200

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     4260

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     4320

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     4380

ctaaagtata tatgagtaac ctgaggctat ggcagggcct gccgccccga cgttggctgc     4440

gagccctggg ccttcacccg aacttggggg gtggggtggg gaaaaggaag aaacgcgggc     4500

gtattggccc caatggggtc tcggtggggt atcgacagag tgccagccct gggaccgaac     4560

cccgcgttta tgaacaaacg acccaacacc gtgcgtttta ttctgtcttt ttattgccgt     4620

catagcgcgg gttccttccg gtattgtctc cttccgtgtt tcagttagcc tccccctagg     4680

gtgggcgaag aactccagca tgagatcccc gcgctggagg atcatccagc cggcgtcccg     4740

gaaaacgatt ccgaagccca acctttcata gaaggcggcg gtggaatcga aatctcgtga     4800

tggcaggttg ggcgtcgctt ggtcggtcat ttcgaacccc agagtcccgc tcagaagaac     4860

tcgtcaagaa ggcgatagaa ggcgatgcgc tgcgaatcgg gagcggcgat accgtaaagc     4920

acgaggaagc ggtcagccca ttcgccgcca agctcttcag caatatcacg ggtagccaac     4980

gctatgtcct gatagcgatc cgccacaccc agccggccac agtcgatgaa tccagaaaag     5040

cggccatttt ccaccatgat attcggcaag caggcatcgc catgggtcac gacgagatcc     5100

tcgccgtcgg gcatgctcgc cttgagcctg gcgaacagtt cggctggcgc gagcccctga     5160

tgctcttcgt ccagatcatc ctgatcgaca agaccggctt ccatccgagt acgtgctcgc     5220

tcgatgcgat gtttcgcttg gtggtcgaat gggcaggtag ccggatcaag cgtatgcagc     5280

cgccgcattg catcagccat gatggatact ttctcggcag gagcaaggtg agatgacagg     5340

agatcctgcc ccggcacttc gcccaatagc agccagtccc ttcccgcttc agtgacaacg     5400

tcgagcacag ctgcgcaagg aacgcccgtc gtggccagcc acgatagccg cgctgcctcg     5460

tcttgcagtt cattcagggc accggacagg tcggtcttga caaaaagaac cgggcgcccc     5520

tgcgctgaca gccggaacac ggcggcatca gagcagccga ttgtctgttg tgcccagtca     5580

tagccgaata gcctctccac ccaagcggcc ggagaacctg cgtgcaatcc atcttgttca     5640

atcatgcgaa acgatcctca tcctgtctct tgatcgatct ttgcaaaagc ctaggcctcc     5700

aaaaaagcct cctcactact tctggaatag ctcagaggcc gaggcggcct cggcctctgc     5760

ataaataaaa aaaattagtc agccatgggg cggagaatgg gcggaactgg gcggagttag     5820

gggcgggatg ggcggagtta ggggcgggac tatggttgct gactaattga gatgcatgct     5880

ttgcatactt ctgcctgctg gggagcctgg ggactttcca cacctggttg ctgactaatt     5940

gagatgcatg ctttgcatac ttctgcctgc tggggagcct ggggactttc cacaccctaa     6000

ctgacacaca ttccacagct ggttctttcc gcctcaggac tcttcctttt tcaatattat     6060

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa     6120

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgcgccctgt     6180

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     6240

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     6300

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     6360

cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga     6420

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     6480

caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg     6540

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt     6600


<210>  4
<211>  26
<212>  DNA
<213>  Synthetic

<400>  4
tgatgtgaat gacttggata cagaca                                            26


<210>  5
<211>  26
<212>  DNA
<213>  Synthetic

<400>  5
gctcattgtt gtactggttg gatatg                                            26


<210>  6
<211>  22
<212>  DNA
<213>  Synthetic

<400>  6
ggacatgtgc agccaagact ct                                                22


<210>  7
<211>  23
<212>  DNA
<213>  Synthetic

<400>  7
cacttcaatc cacccagaaa gct                                               23


<210>  8
<211>  20
<212>  DNA
<213>  Synthetic

<400>  8
caaggacact gagcaagaga                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Synthetic

<400>  9
gcccctcctg ttattatggg                                                   20


<210>  10
<211>  7151
<212>  DNA
<213>  Synthetic

<400>  10
ttctcatgtt tgacagctta tcatcgataa gctttaatgc ggtagtttat cacagttaaa       60

ttgctaacgc agtcaggcac cgtgtatgaa atctaacaat gcgctcatcg tcatcctcgg      120

caccgtcacc ctggatgctg taggcatagg cttggttatg ccggtactgc cgggcctctt      180

gcgggatatc cggatatagt tcctcctttc agcaaaaaac ccctcaagac ccgtttagag      240

gccccaaggg gttatgctag ttattgctca gcggtggcag cagccaactc agcttccttt      300

cgggctttgt tagcagccgg atccatgctt cggttaccca cagtctttcg ccagatgaga      360

ccggtgtcca gggtactggc tcctcatctc actcagccga tgctgtggcc gttacaatgg      420

ggccaaaggg aagaacagtg attattgagc agagttgggg aagtcccaaa gtaacaaaag      480

atggtgtgac tgttgcaaag tcaattgact taaaagataa atacaaaaac attggagcta      540

aacttgttca agatgttgcc aataacacaa atgaagaagc tggggatggc actaccactg      600

ctactgtact ggcacgctct atagccaagg aaggcttcga gaagattagc aaaggtgcta      660

atccagtgga aatcaggaga ggtgtgatgt tagctgttga tgctgtaatt gctgaactta      720

aaaagcagtc taaacctgtg accacccctg aagaaattgc acaggttgct acgatttctg      780

caaacggaga caaagaaatt ggcaatatca tctctgatgc aatgaaaaaa gttggaagaa      840

agggtgtcat cacagtaaag gatggaaaaa cactgaatga tgaattagaa attattgaag      900

gcatgaagtt tgatcgaggc tatatttctc catactttat taatacatca aaaggtcaga      960

aatgtgaatt ccaggatgcc tatgttctgt tgagtgaaaa gaaaatttct agtatccagt     1020

ccattgtacc tgctcttgaa attgccaatg ctcaccgtaa gcctttggtc ataatcgctg     1080

aagatgttga tggagaagct ctaagtacac tcgtcttgaa taggctaaag gttggtcttc     1140

aggttgtggc agtcaaggct ccagggtttg gtgacaatag aaagaaccag cttaaagata     1200

tggctattgc tactggtggt gcagtgtttg gagaagaggg attgaccctg aatcttgaag     1260

acgttcagcc tcatgactta ggaaaagttg gagaggtcat tgtgaccaaa gacgatgcca     1320

tgctcttaaa aggaaaaggt gacaaggctc aaattgaaaa acgtattcaa gaaatcattg     1380

agcagttaga tgtcacaact agtgaatatg aaaaggaaaa actgaatgaa cggcttgcaa     1440

aactttcaga tggagtggct gtgctgaagg ttggtgggac aagtgatgtt gaagtgaatg     1500

aaaagaaaga cagagttaca gatgccctta atgctacaag agctgctgtt gaagaaggca     1560

ttgttttggg agggggttgt gccctccttc gatgcattcc agccttggac tcattgactc     1620

cagctaatga agatcaaaaa attggtatag aaattattaa aagaacactc aaaattccag     1680

caatgaccat tgctaagaat gcaggtgttg aaggatcttt gatagttgag aaaattatgc     1740

aaagttcctc agaagttggt tatgatgcta tgcatatggc tgccgcgcgg caccaggccg     1800

ctgctgtgat gatgatgatg atggctgctg cccatggtat atctccttct taaagttaaa     1860

caaaattatt tctagagggg aattgttatc cgctcacaat tcccctatag tgagtcgtat     1920

taatttcgcg ggatcgagat ctcgatcctc tacgccggac gcatcgtggc cggcatcacc     1980

ggcgccacag gtgcggttgc tggcgcctat atcgccgaca tcaccgatgg ggaagatcgg     2040

gctcgccact tcgggctcat gagcgcttgt ttcggcgtgg gtatggtggc aggccccgtg     2100

gccgggggac tgttgggcgc catctccttg catgcaccat tccttgcggc ggcggtgctc     2160

aacggcctca acctactact gggctgcttc ctaatgcagg agtcgcataa gggagagcgt     2220

cgagatcccg gacaccatcg aatggcgcaa aacctttcgc ggtatggcat gatagcgccc     2280

ggaagagagt caattcaggg tggtgaatgt gaaaccagta acgttatacg atgtcgcaga     2340

gtatgccggt gtctcttatc agaccgtttc ccgcgtggtg aaccaggcca gccacgtttc     2400

tgcgaaaacg cgggaaaaag tggaagcggc gatggcggag ctgaattaca ttcccaaccg     2460

cgtggcacaa caactggcgg gcaaacagtc gttgctgatt ggcgttgcca cctccagtct     2520

ggccctgcac gcgccgtcgc aaattgtcgc ggcgattaaa tctcgcgccg atcaactggg     2580

tgccagcgtg gtggtgtcga tggtagaacg aagcggcgtc gaagcctgta aagcggcggt     2640

gcacaatctt ctcgcgcaac gcgtcagtgg gctgatcatt aactatccgc tggatgacca     2700

ggatgccatt gctgtggaag ctgcctgcac taatgttccg gcgttatttc ttgatgtctc     2760

tgaccagaca cccatcaaca gtattatttt ctcccatgaa gacggtacgc gactgggcgt     2820

ggagcatctg gtcgcattgg gtcaccagca aatcgcgctg ttagcgggcc cattaagttc     2880

tgtctcggcg cgtctgcgtc tggctggctg gcataaatat ctcactcgca atcaaattca     2940

gccgatagcg gaacgggaag gcgactggag tgccatgtcc ggttttcaac aaaccatgca     3000

aatgctgaat gagggcatcg ttcccactgc gatgctggtt gccaacgatc agatggcgct     3060

gggcgcaatg cgcgccatta ccgagtccgg gctgcgcgtt ggtgcggata tctcggtagt     3120

gggatacgac gataccgaag acagctcatg ttatatcccg ccgttaacca ccatcaaaca     3180

ggattttcgc ctgctggggc aaaccagcgt ggaccgcttg ctgcaactct ctcagggcca     3240

ggcggtgaag ggcaatcagc tgttgcccgt ctcactggtg aaaagaaaaa ccaccctggc     3300

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     3360

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgta agttagctca     3420

ctcattaggc accgggatct cgaccgatgc ccttgagagc cttcaaccca gtcagctcct     3480

tccggtgggc gcggggcatg actatcgtcg ccgcacttat gactgtcttc tttatcatgc     3540

aactcgtagg acaggtgccg gcagcgctct gggtcatttt cggcgaggac cgctttcgct     3600

ggagcgcgac gatgatcggc ctgtcgcttg cggtattcgg aatcttgcac gccctcgctc     3660

aagccttcgt cactggtccc gccaccaaac gtttcggcga gaagcaggcc attatcgccg     3720

gcatggcggc cgacgcgctg ggctacgtct tgctggcgtt cgcgacgcga ggctggatgg     3780

ccttccccat tatgattctt ctcgcttccg gcggcatcgg gatgcccgcg ttgcaggcca     3840

tgctgtccag gcaggtagat gacgaccatc agggacagct tcaaggatcg ctcgcggctc     3900

ttaccagcct aacttcgatc actggaccgc tgatcgtcac ggcgatttat gccgcctcgg     3960

cgagcacatg gaacgggttg gcatggattg taggcgccgc cctatacctt gtctgcctcc     4020

ccgcgttgcg tcgcggtgca tggagccggg ccacctcgac ctgaatggaa gccggcggca     4080

cctcgctaac ggattcacca ctccaagaat tggagccaat caattcttgc ggagaactgt     4140

gaatgcgcaa accaaccctt ggcagaacat atccatcgcg tccgccatct ccagcagccg     4200

cacgcggcgc atctcgggca gcgttgggtc ctggccacgg gtgcgcatga tcgtgctcct     4260

gtcgttgagg acccggctag gctggcgggg ttgccttact ggttagcaga atgaatcacc     4320

gatacgcgag cgaacgtgaa gcgactgctg ctgcaaaacg tctgcgacct gagcaacaac     4380

atgaatggtc ttcggtttcc gtgtttcgta aagtctggaa acgcggaagt cagcgccctg     4440

caccattatg ttccggatct gcatcgcagg atgctgctgg ctaccctgtg gaacacctac     4500

atctgtatta acgaagcgct ggcattgacc ctgagtgatt tttctctggt cccgccgcat     4560

ccataccgcc agttgtttac cctcacaacg ttccagtaac cgggcatgtt catcatcagt     4620

aacccgtatc gtgagcatcc tctctcgttt catcggtatc attaccccca tgaacagaaa     4680

tcccccttac acggaggcat cagtgaccaa acaggaaaaa accgccctta acatggcccg     4740

ctttatcaga agccagacat taacgcttct ggagaaactc aacgagctgg acgcggatga     4800

acaggcagac atctgtgaat cgcttcacga ccacgctgat gagctttacc gcagctgcct     4860

cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac     4920

agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt     4980

tggcgggtgt cggggcgcag ccatgaccca gtcacgtagc gatagcggag tgtatactgg     5040

cttaactatg cggcatcaga gcagattgta ctgagagtgc accatatatg cggtgtgaaa     5100

taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca     5160

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     5220

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     5280

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     5340

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     5400

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     5460

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     5520

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     5580

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     5640

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     5700

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     5760

gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     5820

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     5880

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     5940

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     6000

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     6060

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     6120

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     6180

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     6240

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     6300

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     6360

cgccagttaa tagtttgcgc aacgttgttg ccattgctgc aggcatcgtg gtgtcacgct     6420

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     6480

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     6540

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     6600

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     6660

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaac acgggataat accgcgccac     6720

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     6780

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     6840

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     6900

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat     6960

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     7020

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct     7080

aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttc     7140

gtcttcaaga a                                                          7151


<210>  11
<211>  1647
<212>  DNA
<213>  Homo sapiens

<400>  11
atggccaaag atgtaaaatt tggtgcagat gcccgagcct taatgcttca aggtgtagac       60

cttttagccg atgctgtggc cgttacaatg gggccaaagg gaagaacagt gattattgag      120

cagggttggg gaagtcccaa agtaacaaaa gatggtgtga ctgttgcaaa gtcaattgac      180

ttaaaagata aatacaagaa cattggagct aaacttgttc aagatgttgc caataacaca      240

aatgaagaag ctggggatgg cactaccact gctactgtac tggcacgctc tatagccaag      300

gaaggcttcg agaagattag caaaggtgct aatccagtgg aaatcaggag aggtgtgatg      360

ttagctgttg atgctgtaat tgctgaactt aaaaagcagt ctaaacctgt gaccacccct      420

gaagaaattg cacaggttgc tacgatttct gcaaacggag acaaagaaat tggcaatatc      480

atctctgatg caatgaaaaa agttggaaga aagggtgtca tcacagtaaa ggatggaaaa      540

acactgaatg atgaattaga aattattgaa ggcatgaagt ttgatcgagg ctatatttct      600

ccatacttta ttaatacatc aaaaggtcag aaatgtgaat tccaggatgc ctatgttctg      660

ttgagtgaaa agaaaatttc tagtatccag tccattgtac ctgctcttga aattgccaat      720

gctcaccgta agcctttggt cataatcgct gaagatgttg atggagaagc tctaagtaca      780

ctcgtcttga ataggctaaa ggttggtctt caggttgtgg cagtcaaggc tccagggttt      840

ggtgacaata gaaagaacca gcttaaagat atggctattg ctactggtgg tgcagtgttt      900

ggagaagagg gattgaccct gaatcttgaa gacgttcagc ctcatgactt aggaaaagtt      960

ggagaggtca ttgtgaccaa agacgatgcc atgctcttaa aaggaaaagg tgacaaggct     1020

caaattgaaa aacgtattca agaaatcatt gagcagttag atgtcacaac tagtgaatat     1080

gaaaaggaaa aactgaatga acggcttgca aaactttcag atggagtggc tgtgctgaag     1140

gttggtggga caagtgatgt tgaagtgaat gaaaagaaag acagagttac agatgccctt     1200

aatgctacaa gagctgctgt tgaagaaggc attgttttgg gagggggttg tgccctcctt     1260

cgatgcattc cagccttgga ctcattgact ccagctaatg aagatcaaaa aattggtata     1320

gaaattatta aaagaacact caaaattcca gcaatgacca ttgctaagaa tgcaggtgtt     1380

gaaggatctt tgatagttga gaaaattatg caaagttcct cagaagttgg ttatgatgct     1440

atggctggag attttgtgaa tatggtggaa aaaggaatca ttgacccaac aaaggttgtg     1500

agaactgctt tattggatgc tgctggtgtg gcctctctgt taactacagc agaagttgta     1560

gtcacagaaa ttcctaaaga agagaaggac cctggaatgg gtgcaatggg tggaatggga     1620

ggtggtatgg gaggtggcat gttctaa                                         1647


<210>  12
<211>  548
<212>  PRT
<213>  Synthetic

<400>  12

Met Ala Lys Asp Val Lys Phe Gly Ala Asp Ala Arg Ala Leu Met Leu 
1               5                   10                  15      


Gln Gly Val Asp Leu Leu Ala Asp Ala Val Ala Val Thr Met Gly Pro 
            20                  25                  30          


Lys Gly Arg Thr Val Ile Ile Glu Gln Gly Trp Gly Ser Pro Lys Val 
        35                  40                  45              


Thr Lys Asp Gly Val Thr Val Ala Lys Ser Ile Asp Leu Lys Asp Lys 
    50                  55                  60                  


Tyr Lys Asn Ile Gly Ala Lys Leu Val Gln Asp Val Ala Asn Asn Thr 
65                  70                  75                  80  


Asn Glu Glu Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala Arg 
                85                  90                  95      


Ser Ile Ala Lys Glu Gly Phe Glu Lys Ile Ser Lys Gly Ala Asn Pro 
            100                 105                 110         


Val Glu Ile Arg Arg Gly Val Met Leu Ala Val Asp Ala Val Ile Ala 
        115                 120                 125             


Glu Leu Lys Lys Gln Ser Lys Pro Val Thr Thr Pro Glu Glu Ile Ala 
    130                 135                 140                 


Gln Val Ala Thr Ile Ser Ala Asn Gly Asp Lys Glu Ile Gly Asn Ile 
145                 150                 155                 160 


Ile Ser Asp Ala Met Lys Lys Val Gly Arg Lys Gly Val Ile Thr Val 
                165                 170                 175     


Lys Asp Gly Lys Thr Leu Asn Asp Glu Leu Glu Ile Ile Glu Gly Met 
            180                 185                 190         


Lys Phe Asp Arg Gly Tyr Ile Ser Pro Tyr Phe Ile Asn Thr Ser Lys 
        195                 200                 205             


Gly Gln Lys Cys Glu Phe Gln Asp Ala Tyr Val Leu Leu Ser Glu Lys 
    210                 215                 220                 


Lys Ile Ser Ser Ile Gln Ser Ile Val Pro Ala Leu Glu Ile Ala Asn 
225                 230                 235                 240 


Ala His Arg Lys Pro Leu Val Ile Ile Ala Glu Asp Val Asp Gly Glu 
                245                 250                 255     


Ala Leu Ser Thr Leu Val Leu Asn Arg Leu Lys Val Gly Leu Gln Val 
            260                 265                 270         


Val Ala Val Lys Ala Pro Gly Phe Gly Asp Asn Arg Lys Asn Gln Leu 
        275                 280                 285             


Lys Asp Met Ala Ile Ala Thr Gly Gly Ala Val Phe Gly Glu Glu Gly 
    290                 295                 300                 


Leu Thr Leu Asn Leu Glu Asp Val Gln Pro His Asp Leu Gly Lys Val 
305                 310                 315                 320 


Gly Glu Val Ile Val Thr Lys Asp Asp Ala Met Leu Leu Lys Gly Lys 
                325                 330                 335     


Gly Asp Lys Ala Gln Ile Glu Lys Arg Ile Gln Glu Ile Ile Glu Gln 
            340                 345                 350         


Leu Asp Val Thr Thr Ser Glu Tyr Glu Lys Glu Lys Leu Asn Glu Arg 
        355                 360                 365             


Leu Ala Lys Leu Ser Asp Gly Val Ala Val Leu Lys Val Gly Gly Thr 
    370                 375                 380                 


Ser Asp Val Glu Val Asn Glu Lys Lys Asp Arg Val Thr Asp Ala Leu 
385                 390                 395                 400 


Asn Ala Thr Arg Ala Ala Val Glu Glu Gly Ile Val Leu Gly Gly Gly 
                405                 410                 415     


Cys Ala Leu Leu Arg Cys Ile Pro Ala Leu Asp Ser Leu Thr Pro Ala 
            420                 425                 430         


Asn Glu Asp Gln Lys Ile Gly Ile Glu Ile Ile Lys Arg Thr Leu Lys 
        435                 440                 445             


Ile Pro Ala Met Thr Ile Ala Lys Asn Ala Gly Val Glu Gly Ser Leu 
    450                 455                 460                 


Ile Val Glu Lys Ile Met Gln Ser Ser Ser Glu Val Gly Tyr Asp Ala 
465                 470                 475                 480 


Met Ala Gly Asp Phe Val Asn Met Val Glu Lys Gly Ile Ile Asp Pro 
                485                 490                 495     


Thr Lys Val Val Arg Thr Ala Leu Leu Asp Ala Ala Gly Val Ala Ser 
            500                 505                 510         


Leu Leu Thr Thr Ala Glu Val Val Val Thr Glu Ile Pro Lys Glu Glu 
        515                 520                 525             


Lys Asp Pro Gly Met Gly Ala Met Gly Gly Met Gly Gly Gly Met Gly 
    530                 535                 540                 


Gly Gly Met Phe 
545             


<210>  13
<211>  20
<212>  DNA
<213>  Synthetic

<400>  13
aattaaccct cactaaaggg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Synthetic

<400>  14
gtccttatca tcgtcgtctt                                                   20


<210>  15
<211>  22
<212>  DNA
<213>  Synthetic

<400>  15
gtaatacgac tcactatagg gc                                                22


<210>  16
<211>  1756
<212>  DNA
<213>  Synthetic

<400>  16
ggtaccgagg agatctgccg ccgcgatcgc catgcttcga ctacccacag tccttcgcca       60

gatgagacca gtgtcccggg cactggctcc tcatctcact cgggcctatg ccaaagatgt      120

aaaatttggt gcggacgctc gagccttaat gcttcaaggt gtagaccttt tagcagatgc      180

tgtagctgtt acaatggggc caaagggaag aactgtgatt attgaacaga gttggggaag      240

tcccaaagta acaaaagatg gggtcactgt tgcaaagtca attgatttaa aggataaata      300

caaaaatatt ggagctaaac ttgttcagga cgttgccaat aacacaaacg aagaggctgg      360

ggatggcacc accactgcca ctgttctggc acgatctatt gccaaggagg gctttgagaa      420

gatcagcaaa ggggctaatc cagtggaaat ccggagaggt gtgatgttgg ctgtggatgc      480

tgtaattgct gaacttaaga aacagtctaa acctgtgaca acccctgaag aaattgctca      540

ggttgctaca atttctgcaa atggagacaa agacattggg aacatcattt ctgatgcaat      600

gaaaaaggtt ggaagaaagg gtgtcatcac agtgaaggat ggaaaaaccc tgaatgatga      660

gctagaaatt attgaaggca tgaagtttga tagaggatat atttccccgt attttattaa      720

cacatcaaaa ggtcaaaagt gtgaattcca agatgcctat gtcttgttga gtgaaaagaa      780

aatttccagt gttcagtcca ttgtccctgc tcttgaaatt gctaatgctc atcggaagcc      840

attggtcata atcgccgaag acgttgacgg agaagctcta agcacgctgg ttttgaacag      900

gctaaaagtt ggtcttcagg ttgtggcagt caaagctcca ggatttgggg acaataggaa      960

gaaccagctt aaagatatgg ctattgctac tggtggtgca gtgtttggag aagaggggtt     1020

gaatctaaat cttgaagatg ttcaagctca tgacttagga aaagttgggg aggtcattgt     1080

caccaaagat gatgccatgc ttttgaaagg aaaaggtgac aaagctcaca ttgaaaaacg     1140

tattcaagaa atcactgagc agctagacat cacaactagt gaatatgaaa aagaaaagct     1200

gaacgagcga cttgctaaac tttcagatgg agtagctgtg ttgaaggttg gaggaacaag     1260

tgatgttgaa gtgaatgaga aaaaagacag agttactgat gctctcaatg ctacaagagc     1320

agctgttgaa gaaggcattg ttctaggagg gggctgcgct ctgcttcggt gcatcccagc     1380

cttggattca ttaaagcctg ctaatgaaga ccagaaaata ggtatagaaa ttattaaaag     1440

agcacttaaa attcctgcaa tgacgattgc taagaatgca ggtgttgaag gatctttgat     1500

agttgagaaa attctgcaga gttcctcaga agttggttat gacgccatgc ttggagattt     1560

tgtgaacatg gtggaaaaag ggatcattga tccaacaaag gttgtgagaa ctgccttact     1620

ggatgctgct ggggtggcct ccttgctaac tacagccgaa gctgtagtga cagaaattcc     1680

taaagaagag aaggaccctg gaatgggtgc aatgggtggc atgggagggg gtatgggagg     1740

cggcatgttc acgcgt                                                     1756


