                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
 
<120>  Treatment and Prevention of Malaria

<130>  P59644WO

<150>  GB 1816542.3 
<151>  2018-10-10

<150>  GB 1907609.0
<151>  2019-05-29

<160>  146   

<170>  PatentIn version 3.5

<210>  1
<211>  526
<212>  PRT
<213>  Plasmodium falciparum

<400>  1

Met Ile Arg Ile Lys Lys Lys Leu Ile Leu Thr Ile Ile Tyr Ile His 
1               5                   10                  15      


Leu Phe Ile Leu Asn Arg Leu Ser Phe Glu Asn Ala Ile Lys Lys Thr 
            20                  25                  30          


Lys Asn Gln Glu Asn Asn Leu Thr Leu Leu Pro Ile Lys Ser Thr Glu 
        35                  40                  45              


Glu Glu Lys Asp Asp Ile Lys Asn Gly Lys Asp Ile Lys Lys Glu Ile 
    50                  55                  60                  


Asp Asn Asp Lys Glu Asn Ile Lys Thr Asn Asn Ala Lys Asp His Ser 
65                  70                  75                  80  


Thr Tyr Ile Lys Ser Tyr Leu Asn Thr Asn Val Asn Asp Gly Leu Lys 
                85                  90                  95      


Tyr Leu Phe Ile Pro Ser His Asn Ser Phe Ile Lys Lys Tyr Ser Val 
            100                 105                 110         


Phe Asn Gln Ile Asn Asp Gly Met Leu Leu Asn Glu Lys Asn Asp Val 
        115                 120                 125             


Lys Asn Asn Glu Asp Tyr Lys Asn Val Asp Tyr Lys Asn Val Asn Phe 
    130                 135                 140                 


Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr Asn Ile Ala Asn Ser 
145                 150                 155                 160 


Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile Ile 
                165                 170                 175     


Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn Ser 
            180                 185                 190         


Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp Ala 
        195                 200                 205             


Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys Cys 
    210                 215                 220                 


Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu His 
225                 230                 235                 240 


Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp Ile 
                245                 250                 255     


Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr Glu 
            260                 265                 270         


Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro Ser 
        275                 280                 285             


Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met Met 
    290                 295                 300                 


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
305                 310                 315                 320 


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
                325                 330                 335     


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
            340                 345                 350         


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
        355                 360                 365             


Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met Thr 
    370                 375                 380                 


Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys Lys 
385                 390                 395                 400 


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
                405                 410                 415     


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
            420                 425                 430         


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
        435                 440                 445             


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser Asn 
    450                 455                 460                 


Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
465                 470                 475                 480 


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
                485                 490                 495     


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys Met 
            500                 505                 510         


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        515                 520                 525     


<210>  2
<211>  526
<212>  PRT
<213>  Plasmodium falciparum

<400>  2

Met Ile Arg Ile Lys Lys Lys Leu Ile Leu Thr Ile Ile Tyr Ile His 
1               5                   10                  15      


Leu Phe Ile Leu Asn Arg Leu Ser Phe Glu Asn Ala Ile Lys Lys Thr 
            20                  25                  30          


Lys Asn Gln Glu Asn Asn Leu Thr Leu Leu Pro Ile Lys Ser Thr Glu 
        35                  40                  45              


Glu Glu Lys Asp Asp Ile Lys Asn Gly Lys Asp Ile Lys Lys Glu Ile 
    50                  55                  60                  


Asp Asn Asp Lys Glu Asn Ile Lys Thr Asn Asn Ala Lys Asp His Ser 
65                  70                  75                  80  


Thr Tyr Ile Lys Ser Tyr Leu Asn Thr Asn Val Asn Asp Gly Leu Lys 
                85                  90                  95      


Tyr Leu Phe Ile Pro Ser His Asn Ser Phe Ile Lys Lys Tyr Ser Val 
            100                 105                 110         


Phe Asn Gln Ile Asn Asp Gly Met Leu Leu Asn Glu Lys Asn Asp Val 
        115                 120                 125             


Lys Asn Asn Glu Asp Tyr Lys Asn Val Asp Tyr Lys Asn Val Asn Phe 
    130                 135                 140                 


Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr Asn Ile Ala Asn Ser 
145                 150                 155                 160 


Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile Ile 
                165                 170                 175     


Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn Ser 
            180                 185                 190         


Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp Ala 
        195                 200                 205             


Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys Cys 
    210                 215                 220                 


Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu His 
225                 230                 235                 240 


Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp Ile 
                245                 250                 255     


Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr Glu 
            260                 265                 270         


Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro Ser 
        275                 280                 285             


Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met Met 
    290                 295                 300                 


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
305                 310                 315                 320 


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
                325                 330                 335     


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
            340                 345                 350         


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
        355                 360                 365             


Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met Thr 
    370                 375                 380                 


Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys Lys 
385                 390                 395                 400 


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
                405                 410                 415     


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
            420                 425                 430         


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
        435                 440                 445             


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser Asn 
    450                 455                 460                 


Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
465                 470                 475                 480 


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
                485                 490                 495     


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys Met 
            500                 505                 510         


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        515                 520                 525     


<210>  3
<211>  387
<212>  PRT
<213>  Plasmodium falciparum

<400>  3

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser 
            100                 105                 110         


Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr 
        115                 120                 125             


Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser 
    130                 135                 140                 


Asn His Thr Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr 
145                 150                 155                 160 


Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile 
                165                 170                 175     


Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp 
            180                 185                 190         


Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn 
        195                 200                 205             


Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr 
    210                 215                 220                 


Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp 
225                 230                 235                 240 


Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr 
                245                 250                 255     


Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys 
            260                 265                 270         


Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His 
        275                 280                 285             


Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys 
    290                 295                 300                 


Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile 
305                 310                 315                 320 


Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu 
                325                 330                 335     


Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn 
            340                 345                 350         


Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp 
        355                 360                 365             


Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro 
    370                 375                 380                 


Leu Thr Gln 
385         


<210>  4
<211>  387
<212>  PRT
<213>  Plasmodium falciparum

<400>  4

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser 
            100                 105                 110         


Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr 
        115                 120                 125             


Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser 
    130                 135                 140                 


Asn His Thr Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr 
145                 150                 155                 160 


Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile 
                165                 170                 175     


Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp 
            180                 185                 190         


Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn 
        195                 200                 205             


Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr 
    210                 215                 220                 


Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp 
225                 230                 235                 240 


Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr 
                245                 250                 255     


Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys 
            260                 265                 270         


Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His 
        275                 280                 285             


Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys 
    290                 295                 300                 


Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile 
305                 310                 315                 320 


Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu 
                325                 330                 335     


Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn 
            340                 345                 350         


Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp 
        355                 360                 365             


Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro 
    370                 375                 380                 


Leu Thr Gln 
385         


<210>  5
<211>  367
<212>  PRT
<213>  Plasmodium falciparum

<400>  5

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp 
                85                  90                  95      


Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr 
            100                 105                 110         


Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro 
        115                 120                 125             


Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met 
    130                 135                 140                 


Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys 
145                 150                 155                 160 


Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr 
                165                 170                 175     


Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys 
            180                 185                 190         


Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu 
        195                 200                 205             


Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met 
    210                 215                 220                 


Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys 
225                 230                 235                 240 


Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys 
                245                 250                 255     


Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile 
            260                 265                 270         


Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp 
        275                 280                 285             


Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser 
    290                 295                 300                 


Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu 
305                 310                 315                 320 


Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His 
                325                 330                 335     


His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys 
            340                 345                 350         


Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        355                 360                 365         


<210>  6
<211>  367
<212>  PRT
<213>  Plasmodium falciparum

<400>  6

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp 
                85                  90                  95      


Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr 
            100                 105                 110         


Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro 
        115                 120                 125             


Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met 
    130                 135                 140                 


Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys 
145                 150                 155                 160 


Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr 
                165                 170                 175     


Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys 
            180                 185                 190         


Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu 
        195                 200                 205             


Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met 
    210                 215                 220                 


Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys 
225                 230                 235                 240 


Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys 
                245                 250                 255     


Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile 
            260                 265                 270         


Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp 
        275                 280                 285             


Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser 
    290                 295                 300                 


Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu 
305                 310                 315                 320 


Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His 
                325                 330                 335     


His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys 
            340                 345                 350         


Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        355                 360                 365         


<210>  7
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5 amino acid sequence (3D7) excluding signal sequence, 
       flexible N-terminal (amino acids 1 to 139) and flexible loop 
       (amino acids 248 to 296) regions

<400>  7

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Thr Phe 
            100                 105                 110         


Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn 
        195                 200                 205             


Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu 
                245                 250                 255     


Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu 
            260                 265                 270         


Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val 
305                 310                 315                 320 


Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln 
        


<210>  8
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5 amino acid sequence (7G8) excluding signal sequence, 
       flexible N-terminal (amino acids 1 to 139) and flexible loop 
       (amino acids 248 to 296) regions

<400>  8

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Thr Phe 
            100                 105                 110         


Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn 
        195                 200                 205             


Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu 
                245                 250                 255     


Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu 
            260                 265                 270         


Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val 
305                 310                 315                 320 


Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln 
        


<210>  9
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5 amino acid sequence (3D7) excluding signal sequence, 
       flexible N-terminal (amino acids 1 to 159) and flexible loop 
       (amino acids 248 to 296) regions

<400>  9

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Thr Phe Lys Lys Met Met 
                85                  90                  95      


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
            100                 105                 110         


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
        115                 120                 125             


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
    130                 135                 140                 


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
145                 150                 155                 160 


Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met Thr 
                165                 170                 175     


Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys Lys 
            180                 185                 190         


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
        195                 200                 205             


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
    210                 215                 220                 


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
225                 230                 235                 240 


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser Asn 
                245                 250                 255     


Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
            260                 265                 270         


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
        275                 280                 285             


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys Met 
    290                 295                 300                 


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
305                 310                 315             


<210>  10
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5 amino acid sequence (7G8) excluding signal sequence, 
       flexible N-terminal (amino acids 1 to 159) and flexible loop 
       (amino acids 248 to 296) regions

<400>  10

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Thr Phe Lys Lys Met Met 
                85                  90                  95      


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
            100                 105                 110         


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
        115                 120                 125             


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
    130                 135                 140                 


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
145                 150                 155                 160 


Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met Thr 
                165                 170                 175     


Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys Lys 
            180                 185                 190         


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
        195                 200                 205             


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
    210                 215                 220                 


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
225                 230                 235                 240 


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser Asn 
                245                 250                 255     


Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
            260                 265                 270         


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
        275                 280                 285             


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys Met 
    290                 295                 300                 


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
305                 310                 315             


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 heavy chain CDR1

<400>  11

Ser Tyr Ala Met Asn 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 heavy chain CDR2

<400>  12

Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 heavy chain CDR3

<400>  13

Glu Ser Pro Asn Tyr Tyr Asp Ser Ser Gly Tyr Tyr Ser Gly Tyr Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 heavy chain CDR1

<400>  14

Asp Tyr Ala Met His 
1               5   


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 heavy chain CDR2

<400>  15

Gly Ile Ser Trp Asn Ser Ala Ser Met Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 heavy chain CDR3

<400>  16

Asp Pro Ala Pro Pro Tyr Cys Gly Gly Asp Cys Tyr Pro Ser Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 heavy chain CDR1

<400>  17

Ser Tyr Trp Met Ser 
1               5   


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 heavy chain CDR2

<400>  18

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 heavy chain CDR3

<400>  19

Gly Ala Ser Gly Tyr Tyr Tyr Tyr Asn Tyr Gly Met Asp Val 
1               5                   10                  


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 light chain CDR1

<400>  20

Gly Gly Lys Asn Ile Gly Ser Lys Ser Val His 
1               5                   10      


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11/mAb10 light chain CDR2

<400>  21

Asp Asp Ser Asp Arg Pro Ser 
1               5           


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 light chain CDR3

<400>  22

Gln Val Trp Asp Ser Ser Ser Asp His Arg Val 
1               5                   10      


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 light chain CDR1

<400>  23

Gly Asn Asn Ile Gly Ser Lys Ser Val His 
1               5                   10  


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 light chain CDR2

<400>  24

Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 light chain CDR3

<400>  25

Gln Val Trp Asp Ser Ser Arg Asp His Val Val 
1               5                   10      


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 light chain CDR1

<400>  26

Gly Gly Asn Asn Ile Gly Ile Lys Ser Val His 
1               5                   10      


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 light chain CDR3

<400>  27

Gln Val Trp Asp Ser Ser Ser Asp His Pro Gly Val 
1               5                   10          


<210>  28
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 heavy chain FR1

<400>  28

Glu Val Gln Leu Val Gln Ser Gly Ser Asp Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 heavy chain FR2

<400>  29

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  30
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 heavy chain FR3

<400>  30

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11/mAb14 heavy chain FR4

<400>  31

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  32
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 heavy chain FR1

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30  


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 heavy chain FR2

<400>  33

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  34
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 heavy chain FR3

<400>  34

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  35
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 heavy chain FR1

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 heavy chain FR2

<400>  36

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  37
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 heavy chain FR3

<400>  37

Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 heavy chain FR4

<400>  38

Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser 
1               5                   10      


<210>  39
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 light chain FR1

<400>  39

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys 
            20          


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11/mAb10 light chain FR2

<400>  40

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
1               5                   10                  15  


<210>  41
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11/mAb14 light chain FR3

<400>  41

Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11/mAb14/mAb10 light chain FR4

<400>  42

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
1               5                   10              


<210>  43
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 light chain FR1

<400>  43

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Met Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly 
            20              


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 light chain FR2

<400>  44

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
1               5                   10                  15  


<210>  45
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 light chain FR1

<400>  45

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys 
            20          


<210>  46
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 light chain FR3

<400>  46

Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Ala Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Phe Cys 
            20                  25                  30          


<210>  47
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 VH sequence

<400>  47

Glu Val Gln Leu Val Gln Ser Gly Ser Asp Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Pro Asn Tyr Tyr Asp Ser Ser Gly Tyr Tyr Ser Gly 
            100                 105                 110         


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  48
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 VL sequence

<400>  48

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gly Gly Lys Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110     


<210>  49
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 VH sequence

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Ala Ser Met Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Ala Pro Pro Tyr Cys Gly Gly Asp Cys Tyr Pro Ser 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  50
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb14 VL sequence

<400>  50

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Met Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Arg Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110     


<210>  51
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 VH sequence

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ser Gly Tyr Tyr Tyr Tyr Asn Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser 
        115                 120             


<210>  52
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 VL sequence

<400>  52

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ile Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Ala Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Pro Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


<210>  53
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope for the non-neutralising antibodies of the invention

<400>  53

Ser Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Asp Glu Tyr Asn Thr 
1               5                   10                  15      


Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys 
            20                  25      


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain CDR1

<400>  54

Ser Tyr Gly Ile Ser 
1               5   


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain CDR2

<400>  55

Trp Ile Ser Gly Tyr Asp Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain CDR3

<400>  56

Asp Gly Pro Gln Val Gly Asp Phe Asp Trp Gln Val Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 heavy chain CDR1

<400>  57

Asn Tyr Ala Ile Asn 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 heavy chain CDR2

<400>  58

Gly Ile Ile Pro Ile Phe Ala Thr Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 heavy chain CDR3

<400>  59

Asp Lys His Ser Trp Ser Tyr Ala Phe Asp Ile 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain CDR1

<400>  60

Arg Ala Ser Gln Ser Ile Asn Thr Trp Leu Ala 
1               5                   10      


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain CDR2

<400>  61

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain CDR3

<400>  62

Gln Gln Tyr Asn Ser Tyr Leu Tyr Thr 
1               5                   


<210>  63
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 light chain CDR1

<400>  63

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 light chain CDR2

<400>  64

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 light chain CDR3

<400>  65

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  66
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain FR1

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  67
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16/mAb4 heavy chain FR2

<400>  67

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  68
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain FR3

<400>  68

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain FR4

<400>  69

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  70
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 heavy chain FR1

<400>  70

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30  


<210>  71
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 heavy chain FR3

<400>  71

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 heavy chain FR4

<400>  72

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  73
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain FR1

<400>  73

Ala Ile Arg Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  74
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain FR2

<400>  74

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Ser 
1               5                   10                  15  


<210>  75
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain FR3

<400>  75

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain FR4

<400>  76

Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Thr Val 
1               5                   10              


<210>  77
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 light chain FR1

<400>  77

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Leu 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys 
            20          


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 light chain FR2

<400>  78

Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile His 
1               5                   10                  15  


<210>  79
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 light chain FR3

<400>  79

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  80
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 light chain FR4

<400>  80

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
1               5                   10              


<210>  81
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 VH sequence

<400>  81

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Asp Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Pro Gln Val Gly Asp Phe Asp Trp Gln Val Tyr Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  82
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 VL sequence

<400>  82

Ala Ile Arg Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Ser Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Thr Val 
            100                 105                 110 


<210>  83
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 VH sequence

<400>  83

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Ala Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Lys His Ser Trp Ser Tyr Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  84
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb4 VL sequence

<400>  84

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Leu 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile His Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro 
    


<210>  85
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope for the neutralising antibody mAb4 of the invention

<400>  85

Lys Ser Asn Asn Asn Phe Cys Asn Arg Tyr His Tyr Asp Glu Tyr Ile 
1               5                   10                  15      


His Lys Leu Asn Ile Trp Arg 
            20              


<210>  86
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope for the neutralising antibody mAb16 of the invention

<400>  86

Gly Lys Cys Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr 
1               5                   10                  15      


Tyr Asp Lys Lys Ile Cys Met Asp Met Lys Asn Tyr 
            20                  25              


<210>  87
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The neutralising antibody red epitope bin sequence

<400>  87

Gly Lys Cys Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr 
1               5                   10                  15      


Tyr Asp Lys Lys Ile Cys Met Asp Met Lys Asn Tyr Gly Thr Asn Leu 
            20                  25                  30          


Phe Glu Gln 
        35  


<210>  88
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The neutralising antibody blue epitope bin sequence

<400>  88

Lys Ser Tyr Asn Asn Asn Phe Cys Asn Thr Asn Lys Leu Asn Ile Trp 
1               5                   10                  15      


Arg Thr Phe Gln Lys 
            20      


<210>  89
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RH5.1 amino acid sequence

<400>  89

Glu Asn Ala Ile Lys Lys Thr Lys Asn Gln Glu Asn Asn Leu Ala Leu 
1               5                   10                  15      


Leu Pro Ile Lys Ser Thr Glu Glu Glu Lys Asp Asp Ile Lys Asn Gly 
            20                  25                  30          


Lys Asp Ile Lys Lys Glu Ile Asp Asn Asp Lys Glu Asn Ile Lys Thr 
        35                  40                  45              


Asn Asn Ala Lys Asp His Ser Thr Tyr Ile Lys Ser Tyr Leu Asn Thr 
    50                  55                  60                  


Asn Val Asn Asp Gly Leu Lys Tyr Leu Phe Ile Pro Ser His Asn Ser 
65                  70                  75                  80  


Phe Ile Lys Lys Tyr Ser Val Phe Asn Gln Ile Asn Asp Gly Met Leu 
                85                  90                  95      


Leu Asn Glu Lys Asn Asp Val Lys Asn Asn Glu Asp Tyr Lys Asn Val 
            100                 105                 110         


Asp Tyr Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
        115                 120                 125             


Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
    130                 135                 140                 


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr 
145                 150                 155                 160 


Lys His Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly 
                165                 170                 175     


Lys Cys Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
            180                 185                 190         


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala 
        195                 200                 205             


Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp 
    210                 215                 220                 


Asp Ser Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu 
225                 230                 235                 240 


Glu Thr Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr 
                245                 250                 255     


Asp Ser Asn His Ala Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn 
            260                 265                 270         


Arg Ala Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys 
        275                 280                 285             


Leu Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys 
    290                 295                 300                 


Met Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys 
305                 310                 315                 320 


Tyr Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp 
                325                 330                 335     


Glu Tyr Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn 
            340                 345                 350         


Lys Asp Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu 
        355                 360                 365             


Leu Thr Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr 
    370                 375                 380                 


Ile Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu 
385                 390                 395                 400 


Tyr His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys 
                405                 410                 415     


Ile Lys Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys 
            420                 425                 430         


Arg Ile Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp 
        435                 440                 445             


His Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His 
    450                 455                 460                 


Leu Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe 
465                 470                 475                 480 


Asn Asp Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn 
                485                 490                 495     


Lys Pro Leu Thr Gln Glu Pro Glu Ala 
            500                 505 


<210>  90
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5 (PfRH5FL) sequence of amino acids E26-Q526 of the 3D7 clone
       P. falciparum reference sequence, with mutations to delete 
       N-linked glycosylation (N38Q and N214Q) and with an additional 
       C-terminal AviTag and Strep-II tag in tandem

<400>  90

Glu Asn Ala Ile Lys Lys Thr Lys Asn Gln Glu Asn Gln Leu Thr Leu 
1               5                   10                  15      


Leu Pro Ile Lys Ser Thr Glu Glu Glu Lys Asp Asp Ile Lys Asn Gly 
            20                  25                  30          


Lys Asp Ile Lys Lys Glu Ile Asp Asn Asp Lys Glu Asn Ile Lys Thr 
        35                  40                  45              


Asn Asn Ala Lys Asp His Ser Thr Tyr Ile Lys Ser Tyr Leu Asn Thr 
    50                  55                  60                  


Asn Val Asn Asp Gly Leu Lys Tyr Leu Phe Ile Pro Ser His Asn Ser 
65                  70                  75                  80  


Phe Ile Lys Lys Tyr Ser Val Phe Asn Gln Ile Asn Asp Gly Met Leu 
                85                  90                  95      


Leu Asn Glu Lys Asn Asp Val Lys Asn Asn Glu Asp Tyr Lys Asn Val 
            100                 105                 110         


Asp Tyr Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
        115                 120                 125             


Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
    130                 135                 140                 


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr 
145                 150                 155                 160 


Lys His Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly 
                165                 170                 175     


Lys Cys Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Gln Glu Thr Tyr 
            180                 185                 190         


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala 
        195                 200                 205             


Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp 
    210                 215                 220                 


Asp Ser Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu 
225                 230                 235                 240 


Glu Thr Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr 
                245                 250                 255     


Asp Ser Asn His Thr Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn 
            260                 265                 270         


Arg Thr Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys 
        275                 280                 285             


Leu Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys 
    290                 295                 300                 


Met Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys 
305                 310                 315                 320 


Tyr Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp 
                325                 330                 335     


Glu Tyr Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn 
            340                 345                 350         


Lys Asp Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu 
        355                 360                 365             


Leu Thr Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr 
    370                 375                 380                 


Ile Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu 
385                 390                 395                 400 


Tyr His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys 
                405                 410                 415     


Ile Lys Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys 
            420                 425                 430         


Arg Ile Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp 
        435                 440                 445             


His Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His 
    450                 455                 460                 


Leu Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe 
465                 470                 475                 480 


Asn Asp Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn 
                485                 490                 495     


Lys Pro Leu Thr Gln Gly Ser Ala Ser Gly Leu Asn Asp Ile Phe Glu 
            500                 505                 510         


Ala Gln Lys Ile Glu Trp His Glu Trp Ser His Pro Gln Phe Glu Lys 
        515                 520                 525             


<210>  91
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5deltaNL amino acid sequence based on the 3D7 clone P. 
       falciparum reference sequence - residues K140-K247 and N297-Q526 
       with mutations to delete N-linked glycosylation sequons (T216A 
       and T299A) and with the addition of a C-terminal C-tag

<400>  91

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe 
            100                 105                 110         


Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn 
        195                 200                 205             


Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu 
                245                 250                 255     


Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu 
            260                 265                 270         


Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val 
305                 310                 315                 320 


Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln Glu Pro Glu Ala 
            340         


<210>  92
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfCyRPA based on the 3D7 clone P. falciparum sequence and 
       comprised amino acids D29-E362 with mutations introduced to 
       ablate N-linked glycosylation (S147A, T324A and T340A) and also 
       included a C-terminal CD4 tag comprising rat domains 3 and 4

<400>  92

Asp Ser Arg His Val Phe Ile Arg Thr Glu Leu Ser Phe Ile Lys Asn 
1               5                   10                  15      


Asn Val Pro Cys Ile Arg Asp Met Phe Phe Ile Tyr Lys Arg Glu Leu 
            20                  25                  30          


Tyr Asn Ile Cys Leu Asp Asp Leu Lys Gly Glu Glu Asp Glu Thr His 
        35                  40                  45              


Ile Tyr Val Gln Lys Lys Val Lys Asp Ser Trp Ile Thr Leu Asn Asp 
    50                  55                  60                  


Leu Phe Lys Glu Thr Asp Leu Thr Gly Arg Pro His Ile Phe Ala Tyr 
65                  70                  75                  80  


Val Asp Val Glu Glu Ile Ile Ile Leu Leu Cys Glu Asp Glu Glu Phe 
                85                  90                  95      


Ser Asn Arg Lys Lys Asp Met Thr Cys His Arg Phe Tyr Ser Asn Asp 
            100                 105                 110         


Gly Lys Glu Tyr Asn Asn Ala Glu Ile Thr Ile Ser Asp Tyr Ile Leu 
        115                 120                 125             


Lys Asp Lys Leu Leu Ser Ser Tyr Val Ser Leu Pro Leu Lys Ile Glu 
    130                 135                 140                 


Asn Arg Glu Tyr Phe Leu Ile Cys Gly Val Ser Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Asp Asp Asn Lys Lys Asp Asp Ile Leu Cys Met Ala Ser His Asp Lys 
                165                 170                 175     


Gly Glu Thr Trp Gly Thr Lys Ile Val Ile Lys Tyr Asp Asn Tyr Lys 
            180                 185                 190         


Leu Gly Val Gln Tyr Phe Phe Leu Arg Pro Tyr Ile Ser Lys Asn Asp 
        195                 200                 205             


Leu Ser Phe His Phe Tyr Val Gly Asp Asn Ile Asn Asn Val Lys Asn 
    210                 215                 220                 


Val Asn Phe Ile Glu Cys Thr His Glu Lys Asp Leu Glu Phe Val Cys 
225                 230                 235                 240 


Ser Asn Arg Asp Phe Leu Lys Asp Asn Lys Val Leu Gln Asp Val Ser 
                245                 250                 255     


Thr Leu Asn Asp Glu Tyr Ile Val Ser Tyr Gly Asn Asp Asn Asn Phe 
            260                 265                 270         


Ala Glu Cys Tyr Ile Phe Phe Asn Asn Glu Asn Ser Ile Leu Ile Lys 
        275                 280                 285             


Pro Glu Lys Tyr Gly Asn Thr Ala Ala Gly Cys Tyr Gly Gly Thr Phe 
    290                 295                 300                 


Val Lys Ile Asp Glu Asn Arg Ala Leu Phe Ile Tyr Ser Ser Ser Gln 
305                 310                 315                 320 


Gly Ile Tyr Asn Ile His Thr Ile Tyr Tyr Ala Asn Tyr Glu Gly Ala 
                325                 330                 335     


Pro Ser Thr Ser Ile Thr Ala Tyr Lys Ser Glu Gly Glu Ser Ala Glu 
            340                 345                 350         


Phe Ser Phe Pro Leu Asn Leu Gly Glu Glu Ser Leu Gln Gly Glu Leu 
        355                 360                 365             


Arg Trp Lys Ala Glu Lys Ala Pro Ser Ser Gln Ser Trp Ile Thr Phe 
    370                 375                 380                 


Ser Leu Lys Asn Gln Lys Val Ser Val Gln Lys Ser Thr Ser Asn Pro 
385                 390                 395                 400 


Lys Phe Gln Leu Ser Glu Thr Leu Pro Leu Thr Leu Gln Ile Pro Gln 
                405                 410                 415     


Val Ser Leu Gln Phe Ala Gly Ser Gly Asn Leu Thr Leu Thr Leu Asp 
            420                 425                 430         


Arg Gly Ile Leu Tyr Gln Glu Val Asn Leu Val Val Met Lys Val Thr 
        435                 440                 445             


Gln Pro Asp Ser Asn Thr Leu Thr Cys Glu Val Met Gly Pro Thr Ser 
    450                 455                 460                 


Pro Lys Met Arg Leu Ile Leu Lys Gln Glu Asn Gln Glu Ala Arg Val 
465                 470                 475                 480 


Ser Arg Gln Glu Lys Val Ile Gln Val Gln Ala Pro Glu Ala Gly Val 
                485                 490                 495     


Trp Gln Cys Leu Leu Ser Glu Gly Glu Glu Val Lys Met Asp Ser Lys 
            500                 505                 510         


Ile Gln Val Leu Ser Lys Gly Leu Asn Ser Gly Ser Leu His His Ile 
        515                 520                 525             


Leu Asp Ala Gln Lys Met Leu Trp Asn His Arg Asp Arg Asn Leu Pro 
    530                 535                 540                 


Pro Leu Ala Pro Leu Gly Pro His His His His His His 
545                 550                 555         


<210>  93
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfCyRPA based on the 3D7 clone P. falciparum sequence and 
       comprised amino acids D29-E362 with mutations introduced to 
       ablate N-linked glycosylation (S147A, T324A and T340A) and also 
       included a C-terminal 4-amino acid C-tag

<400>  93

Asp Ser Arg His Val Phe Ile Arg Thr Glu Leu Ser Phe Ile Lys Asn 
1               5                   10                  15      


Asn Val Pro Cys Ile Arg Asp Met Phe Phe Ile Tyr Lys Arg Glu Leu 
            20                  25                  30          


Tyr Asn Ile Cys Leu Asp Asp Leu Lys Gly Glu Glu Asp Glu Thr His 
        35                  40                  45              


Ile Tyr Val Gln Lys Lys Val Lys Asp Ser Trp Ile Thr Leu Asn Asp 
    50                  55                  60                  


Leu Phe Lys Glu Thr Asp Leu Thr Gly Arg Pro His Ile Phe Ala Tyr 
65                  70                  75                  80  


Val Asp Val Glu Glu Ile Ile Ile Leu Leu Cys Glu Asp Glu Glu Phe 
                85                  90                  95      


Ser Asn Arg Lys Lys Asp Met Thr Cys His Arg Phe Tyr Ser Asn Asp 
            100                 105                 110         


Gly Lys Glu Tyr Asn Asn Ala Glu Ile Thr Ile Ser Asp Tyr Ile Leu 
        115                 120                 125             


Lys Asp Lys Leu Leu Ser Ser Tyr Val Ser Leu Pro Leu Lys Ile Glu 
    130                 135                 140                 


Asn Arg Glu Tyr Phe Leu Ile Cys Gly Val Ser Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Asp Asp Asn Lys Lys Asp Asp Ile Leu Cys Met Ala Ser His Asp Lys 
                165                 170                 175     


Gly Glu Thr Trp Gly Thr Lys Ile Val Ile Lys Tyr Asp Asn Tyr Lys 
            180                 185                 190         


Leu Gly Val Gln Tyr Phe Phe Leu Arg Pro Tyr Ile Ser Lys Asn Asp 
        195                 200                 205             


Leu Ser Phe His Phe Tyr Val Gly Asp Asn Ile Asn Asn Val Lys Asn 
    210                 215                 220                 


Val Asn Phe Ile Glu Cys Thr His Glu Lys Asp Leu Glu Phe Val Cys 
225                 230                 235                 240 


Ser Asn Arg Asp Phe Leu Lys Asp Asn Lys Val Leu Gln Asp Val Ser 
                245                 250                 255     


Thr Leu Asn Asp Glu Tyr Ile Val Ser Tyr Gly Asn Asp Asn Asn Phe 
            260                 265                 270         


Ala Glu Cys Tyr Ile Phe Phe Asn Asn Glu Asn Ser Ile Leu Ile Lys 
        275                 280                 285             


Pro Glu Lys Tyr Gly Asn Thr Ala Ala Gly Cys Tyr Gly Gly Thr Phe 
    290                 295                 300                 


Val Lys Ile Asp Glu Asn Arg Ala Leu Phe Ile Tyr Ser Ser Ser Gln 
305                 310                 315                 320 


Gly Ile Tyr Asn Ile His Thr Ile Tyr Tyr Ala Asn Tyr Glu Gly Gly 
                325                 330                 335     


Gly Gly Ser Glu Pro Glu Ala 
            340             


<210>  94
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfP113Nt, encoding amino acids Y23-K219 of PfP113 (3D7) was 
       expressed encoding C-terminal tags comprising CD4d3+4, a biotin 
       acceptor peptide and a His6 tag in tandem

<400>  94

Tyr Val His Asn Asp Val Ile Lys Phe Gly Glu Glu Asn Ser Leu Lys 
1               5                   10                  15      


Cys Ser Gln Gly Asn Leu Tyr Val Leu His Cys Glu Val Gln Cys Leu 
            20                  25                  30          


Asn Gly Asn Asn Glu Ile Ile His Lys Arg Cys Asn Asp Asp Ile Glu 
        35                  40                  45              


Lys Lys Cys Asn Gly Asn Asn Lys Cys Ile Tyr Phe Phe Glu Tyr Glu 
    50                  55                  60                  


Leu Arg Lys Lys Thr Gln Ser Phe Arg Asn Lys Asn Ser Ile Glu Ile 
65                  70                  75                  80  


Ser Glu Cys Val Glu Ser Glu Gln Asn Glu Val Lys Thr Ser Thr Thr 
                85                  90                  95      


Cys Leu Leu Ser Asn Ser Phe Ile Leu Asp Glu Ala Phe Ile Gln Tyr 
            100                 105                 110         


Phe Phe Phe Ile Lys Asn Lys Asn Glu Glu Pro Val Ile Cys Lys Asp 
        115                 120                 125             


Gly Asn Ile Asn Ile Lys Ser Ala Leu Leu His Ser Pro Phe Cys Glu 
    130                 135                 140                 


Ile Lys Leu Lys Asp Ile Ser Glu Tyr Ile Arg Lys Lys Cys Asp Asn 
145                 150                 155                 160 


Asn Lys Glu Cys Leu Ile Asp Pro Leu Asp Val Gln Lys Asn Leu Leu 
                165                 170                 175     


Asn Glu Glu Asp Pro Cys Tyr Ile Asn Asn Ala Tyr Val Ser Val Asn 
            180                 185                 190         


Val Val Cys Asn Lys Gly Ala Pro Ser Thr Ser Ile Thr Ala Tyr Lys 
        195                 200                 205             


Ser Glu Gly Glu Ser Ala Glu Phe Ser Phe Pro Leu Asn Leu Gly Glu 
    210                 215                 220                 


Glu Ser Leu Gln Gly Glu Leu Arg Trp Lys Ala Glu Lys Ala Pro Ser 
225                 230                 235                 240 


Ser Gln Ser Trp Ile Thr Phe Ser Leu Lys Asn Gln Lys Val Ser Val 
                245                 250                 255     


Gln Lys Ser Thr Ser Asn Pro Lys Phe Gln Leu Ser Glu Thr Leu Pro 
            260                 265                 270         


Leu Thr Leu Gln Ile Pro Gln Val Ser Leu Gln Phe Ala Gly Ser Gly 
        275                 280                 285             


Asn Leu Thr Leu Thr Leu Asp Arg Gly Ile Leu Tyr Gln Glu Val Asn 
    290                 295                 300                 


Leu Val Val Met Lys Val Thr Gln Pro Asp Ser Asn Thr Leu Thr Cys 
305                 310                 315                 320 


Glu Val Met Gly Pro Thr Ser Pro Lys Met Arg Leu Ile Leu Lys Gln 
                325                 330                 335     


Glu Asn Gln Glu Ala Arg Val Ser Arg Gln Glu Lys Val Ile Gln Val 
            340                 345                 350         


Gln Ala Pro Glu Ala Gly Val Trp Gln Cys Leu Leu Ser Glu Gly Glu 
        355                 360                 365             


Glu Val Lys Met Asp Ser Lys Ile Gln Val Leu Ser Lys Gly Leu Asn 
    370                 375                 380                 


Ser Gly Ser Leu His His Ile Leu Asp Ala Gln Lys Met Leu Trp Asn 
385                 390                 395                 400 


His Arg Asp Arg Asn Leu Pro Pro Leu Ala Pro Leu Gly Pro His His 
                405                 410                 415     


His His His His 
            420 


<210>  95
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5Nt encoding amino acids F25-K140 of PfRH5 (3D7) was 
       expressed encoding C-terminal tags comprising CD4d3+4, a biotin 
       acceptor peptide and a His6 tag in tandem

<400>  95

Phe Glu Asn Ala Ile Lys Lys Thr Lys Asn Gln Glu Asn Asn Leu Ala 
1               5                   10                  15      


Leu Leu Pro Ile Lys Ser Thr Glu Glu Glu Lys Asp Asp Ile Lys Asn 
            20                  25                  30          


Gly Lys Asp Ile Lys Lys Glu Ile Asp Asn Asp Lys Glu Asn Ile Lys 
        35                  40                  45              


Thr Asn Asn Ala Lys Asp His Ser Thr Tyr Ile Lys Ser Tyr Leu Asn 
    50                  55                  60                  


Thr Asn Val Asn Asp Gly Leu Lys Tyr Leu Phe Ile Pro Ser His Asn 
65                  70                  75                  80  


Ser Phe Ile Lys Lys Tyr Ser Val Phe Asn Gln Ile Asn Asp Gly Met 
                85                  90                  95      


Leu Leu Asn Glu Lys Asn Asp Val Lys Asn Asn Glu Asp Tyr Lys Asn 
            100                 105                 110         


Val Asp Tyr Lys Gly Ala Pro Ser Thr Ser Ile Thr Ala Tyr Lys Ser 
        115                 120                 125             


Glu Gly Glu Ser Ala Glu Phe Ser Phe Pro Leu Asn Leu Gly Glu Glu 
    130                 135                 140                 


Ser Leu Gln Gly Glu Leu Arg Trp Lys Ala Glu Lys Ala Pro Ser Ser 
145                 150                 155                 160 


Gln Ser Trp Ile Thr Phe Ser Leu Lys Asn Gln Lys Val Ser Val Gln 
                165                 170                 175     


Lys Ser Thr Ser Asn Pro Lys Phe Gln Leu Ser Glu Thr Leu Pro Leu 
            180                 185                 190         


Thr Leu Gln Ile Pro Gln Val Ser Leu Gln Phe Ala Gly Ser Gly Asn 
        195                 200                 205             


Leu Thr Leu Thr Leu Asp Arg Gly Ile Leu Tyr Gln Glu Val Asn Leu 
    210                 215                 220                 


Val Val Met Lys Val Thr Gln Pro Asp Ser Asn Thr Leu Thr Cys Glu 
225                 230                 235                 240 


Val Met Gly Pro Thr Ser Pro Lys Met Arg Leu Ile Leu Lys Gln Glu 
                245                 250                 255     


Asn Gln Glu Ala Arg Val Ser Arg Gln Glu Lys Val Ile Gln Val Gln 
            260                 265                 270         


Ala Pro Glu Ala Gly Val Trp Gln Cys Leu Leu Ser Glu Gly Glu Glu 
        275                 280                 285             


Val Lys Met Asp Ser Lys Ile Gln Val Leu Ser Lys Gly Leu Asn Ser 
    290                 295                 300                 


Gly Ser Leu His His Ile Leu Asp Ala Gln Lys Met Leu Trp Asn His 
305                 310                 315                 320 


Arg Asp Arg Asn Leu Pro Pro Leu Ala Pro Leu Gly Pro His His His 
                325                 330                 335     


His His His 
            


<210>  96
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 1

<400>  96
acaggtgccc actcccaggt gcag                                              24


<210>  97
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 2

<400>  97
aaggtgtcca gtgtgargtg cag                                               23


<210>  98
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 3

<400>  98
cccagatggg tcctgtccca ggtgcag                                           27


<210>  99
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 4

<400>  99
caaggagtct gttccgaggt gcag                                              24


<210>  100
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 5

<400>  100
ggaaggtgtg cacgccgctg gtc                                               23


<210>  101
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 6

<400>  101
atgaggstcc cygctcagct gctgg                                             25


<210>  102
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 7

<400>  102
ctcttcctcc tgctactctg gctcccag                                          28


<210>  103
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 8

<400>  103
atttctctgt tgctctggat ctctg                                             25


<210>  104
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 9

<400>  104
gtttctcgta gtctgctttg ctca                                              24


<210>  105
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 10

<400>  105
ggtcctgggc ccagtctgtg ctg                                               23


<210>  106
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 11

<400>  106
ggtcctgggc ccagtctgcc ctg                                               23


<210>  107
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 12

<400>  107
gctctgtgac ctcctatgag ctg                                               23


<210>  108
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 13

<400>  108
ggtctctctc scagcytgtg ctg                                               23


<210>  109
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 14

<400>  109
gttcttgggc caattttatg ctg                                               23


<210>  110
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 15

<400>  110
ggtccaattc ycaggctgtg gtg                                               23


<210>  111
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 16

<400>  111
gagtggattc tcagactgtg gtg                                               23


<210>  112
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 17

<400>  112
caccagtgtg gccttgttgg cttg                                              24


<210>  113
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 18

<400>  113
ctttttctag tagcaactgc aaccggtgta cattccgagg tgcagctggt gcag             54


<210>  114
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 19

<400>  114
ctttttctag tagcaactgc aaccggtgta cattctgagg tgcagctggt ggag             54


<210>  115
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 20

<400>  115
ctttttctag tagcaactgc aaccggtgta cattcccagg tgcagctgca ggag             54


<210>  116
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 21

<400>  116
ctttttctag tagcaactgc aaccggtgta cattctgagg tgcagctgtt ggag             54


<210>  117
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 22

<400>  117
ctttttctag tagcaactgc aaccggtgta cattcccagg tgcagctaca gcagtg           56


<210>  118
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 23

<400>  118
ctttttctag tagcaactgc aaccggtgta cattcccagg ttcagctggt gcag             54


<210>  119
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 24

<400>  119
ctttttctag tagcaactgc aaccggtgta cattcccagg tccagctggt acag             54


<210>  120
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 25

<400>  120
ctttttctag tagcaactgc aaccggtgta cattctgaag tgcagctggt ggag             54


<210>  121
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 26

<400>  121
ctttttctag tagcaactgc aaccggtgta cattcccagg tacagctgca gcag             54


<210>  122
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 27

<400>  122
ctttttctag tagcaactgc aaccggtgta cattcccagc tgcagctgca ggag             54


<210>  123
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 28

<400>  123
ctttttctag tagcaactgc aaccggtgta cattctcagg tgcagctggt ggag             54


<210>  124
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 29

<400>  124
gatgggccct tggtcgacgc tgaggagacg gtgaccag                               38


<210>  125
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 30

<400>  125
gatgggccct tggtcgacgc tgaagagacg gtgaccattg                             40


<210>  126
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 31

<400>  126
gatgggccct tggtcgacgc tgaggagacg gtgaccgtg                              39


<210>  127
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 32

<400>  127
ctttttctag tagcaactgc aaccggtgta cattctgaca tccagatgac ccagtc           56


<210>  128
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 33

<400>  128
ctttttctag tagcaactgc aaccggtgta cattcagaca tccagttgac ccagtct          57


<210>  129
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 34

<400>  129
ctttttctag tagcaactgc aaccggtgta cattgtgcca tccggatgac ccagtc           56


<210>  130
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 35

<400>  130
ctttttctag tagcaactgc aaccggtgta catggggata ttgtgatgac ccagac           56


<210>  131
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 36

<400>  131
ctttttctag tagcaactgc aaccggtgta catggggata ttgtgatgac tcagtc           56


<210>  132
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 37

<400>  132
ctttttctag tagcaactgc aaccggtgta cattcagaaa ttgtgttgac acagtc           56


<210>  133
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 38

<400>  133
ctttttctag tagcaactgc aaccggtgta cattcagaaa tagtgatgac gcagtc           56


<210>  134
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 39

<400>  134
ctttttctag tagcaactgc aaccggtgta cattcagaaa ttgtgttgac gcagtct          57


<210>  135
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 40

<400>  135
ctttttctag tagcaactgc aaccggtgta cattcggaca tcgtgatgac ccagtc           56


<210>  136
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 41

<400>  136
atggtgcagc caccgtacgt ttgatytcca ccttggtc                               38


<210>  137
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 42

<400>  137
atggtgcagc caccgtacgt ttgatatcca ctttggtc                               38


<210>  138
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 43

<400>  138
atggtgcagc caccgtacgt ttaatctcca gtcgtgtc                               38


<210>  139
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 44

<400>  139
atggtgcagc caccgtacgt ctgatttcca ccttggtc                               38


<210>  140
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 45

<400>  140
ctttttctag tagcaactgc aaccggttcc tgggcccagt ctgtgctgac kcag             54


<210>  141
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 46

<400>  141
ctttttctag tagcaactgc aaccggttcc tgggcccagt ctgccctgac tcag             54


<210>  142
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 47

<400>  142
ctttttctag tagcaactgc aaccggttct gtgacctcct atgagctgac wcag             54


<210>  143
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 48

<400>  143
ctttttctag tagcaactgc aaccggttct ctctcscagc ytgtgctgac tca              53


<210>  144
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 49

<400>  144
ctttttctag tagcaactgc aaccggttct tgggccaatt ttatgctgac tcag             54


<210>  145
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 50

<400>  145
ctttttctag tagcaactgc aaccggttcc aattcycagr ctgtggtgac ycag             54


<210>  146
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer number 51

<400>  146
ggcttgaagc tcctcactcg agggygggaa cagagtg                                37


