                         SEQUENCE LISTING

<110>  VIVET THERAPEUTICS
 
<120>  CODON-OPTIMIZED TRANSGENE FOR THE TREATMENT OF PROGRESSIVE 
       FAMILIAR INTRAHEPATIC CHOLESTASIS TYPE 3 (PFIC3)

<130>  BCT190349QT

<150>  EP18306349
<151>  2018-10-12

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  3840
<212>  DNA
<213>  artificial sequence

<220>
<223>  Codon-optimized sequence encoding MDR3 isoform A

<400>  1
atggatctgg aggccgccaa gaacggcacc gcctggagac ccacaagcgc cgagggcgac       60

ttcgagctgg gcatcagctc caagcagaag agaaagaaga ccaagacagt gaagatgatc      120

ggcgtgctga cactgttcag gtactccgac tggcaggata agctgtttat gtctctgggc      180

accatcatgg caatcgccca cggcagcggc ctgcctctga tgatgatcgt gttcggcgag      240

atgaccgaca agtttgtgga tacagccggc aatttctcct ttcccgtgaa cttctctctg      300

agcctgctga accctggcaa gatcctggag gaggagatga caagatatgc ctactattac      360

tctggcctgg gagcaggcgt gctggtggca gcatacatcc aggtgagctt ctggaccctg      420

gcagcaggcc ggcagatcag aaagatcagg cagaagttct ttcacgccat cctgcgccag      480

gagatcggct ggtttgacat caatgatacc acagagctga acacccggct gacagacgac      540

atctctaaga tcagcgaggg catcggcgat aaagtgggca tgttctttca ggccgtggcc      600

acattctttg ccggcttcat cgtgggcttt atcaggggct ggaagctgac cctggtcatc      660

atggccatct ctccaatcct gggcctgagc gccgccgtgt gggcaaagat cctgtccgcc      720

ttctctgaca aggagctggc cgcctacgcc aaggcaggag cagtggcaga ggaggccctg      780

ggcgccatcc gcaccgtgat cgcctttggc ggccagaata aggagctgga gcggtatcag      840

aagcacctgg agaacgccaa ggagatcggc atcaagaagg ccatctccgc caatatctct      900

atgggcatcg ccttcctgct gatctatgcc agctacgccc tggccttttg gtatggcagc      960

accctggtca tcagcaagga gtacaccatc ggcaatgcca tgacagtgtt ctttagcatc     1020

ctgatcggag ccttctccgt gggacaggca gcaccatgca tcgacgcctt cgccaacgcc     1080

agaggcgcag cctacgtgat ctttgacatc atcgataaca atccaaagat cgactccttt     1140

tctgagcggg gccacaagcc cgattccatc aagggcaatc tggagttcaa cgacgtgcac     1200

tttagctatc cctcccgcgc caatgtgaag atcctgaagg gcctgaacct gaaggtgcag     1260

tccggacaga cagtggccct ggtgggctct agcggatgcg gcaagtctac cacagtgcag     1320

ctgatccagc ggctgtatga cccagatgag ggcaccatca acatcgacgg ccaggacatc     1380

cgcaacttca atgtgaacta cctgcgggag atcatcggcg tggtgtctca ggagcccgtg     1440

ctgtttagca ccacaatcgc cgagaatatc tgttatggcc gcggcaacgt gacaatggat     1500

gagatcaaga aggccgtgaa ggaggccaat gcctacgagt tcatcatgaa gctgccccag     1560

aagtttgaca ccctggtggg agagagaggc gcccagctga gcggaggcca gaagcagagg     1620

atcgccatcg ccagagccct ggtgaggaac cctaagatcc tgctgctgga cgaggccacc     1680

tccgccctgg atacagagtc tgaggcagag gtgcaggccg ccctggataa ggcccgcgag     1740

ggacggacca caatcgtgat cgcccacaga ctgagcacag tgaggaatgc cgacgtgatc     1800

gccggcttcg aggatggcgt gatcgtggag cagggcagcc actccgagct gatgaagaag     1860

gagggcgtgt acttcaagct ggtgaacatg cagacctctg gcagccagat ccagtccgag     1920

gagtttgagc tgaatgacga gaaggcagca acaaggatgg cacctaacgg atggaagagc     1980

agactgttca ggcactccac ccagaagaat ctgaagaact ctcagatgtg ccagaagagc     2040

ctggacgtgg aaaccgatgg actggaggca aatgtgccac ccgtgagctt cctgaaggtg     2100

ctgaagctga acaagacaga gtggccatat tttgtggtgg gcaccgtgtg cgcaatcgca     2160

aatggcggcc tgcagccagc cttcagcgtg atcttttccg agatcatcgc catcttcggc     2220

cctggcgacg atgccgtgaa gcagcagaag tgtaacatct tttccctgat cttcctgttt     2280

ctgggcatca tctctttctt taccttcttt ctgcagggct tcacatttgg caaggccggc     2340

gagatcctga cacggagact gagaagcatg gccttcaagg ccatgctgag gcaggatatg     2400

tcctggtttg acgatcacaa gaacagcacc ggcgccctgt ccaccagact ggcaacagac     2460

gcagcacagg tgcagggagc aaccggcaca aggctggccc tgatcgccca gaatatcgcc     2520

aacctgggca caggcatcat catctctttc atctacggct ggcagctgac cctgctgctg     2580

ctggcagtgg tgccaatcat cgccgtgagc ggcatcgtgg agatgaagct gctggccggc     2640

aatgccaaga gagacaagaa ggagctggag gcagcaggca agatcgcaac cgaggccatc     2700

gagaacatcc gcaccgtggt gagcctgaca caggagcgga agttcgagtc catgtatgtg     2760

gagaagctgt atggccctta ccgcaattcc gtgcagaagg cccacatcta cggcatcacc     2820

ttttccatct ctcaggcttt catgtatttt tcttacgccg gctgcttccg gtttggcgcc     2880

tatctgatcg tgaacggcca catgaggttc cgcgatgtga tcctggtgtt ctctgccatc     2940

gtgtttggag cagtggccct gggacacgcc tcctcttttg cccctgacta tgcaaaggca     3000

aagctgtccg ccgcacacct gttcatgctg tttgagagac agcctctgat cgatagctac     3060

tccgaggagg gcctgaagcc agacaagttc gagggcaata tcacattcaa cgaggtggtg     3120

tttaattatc caaccagggc caacgtgccc gtgctgcagg gcctgagcct ggaggtgaag     3180

aagggacaga cactggccct ggtgggcagc tccggatgcg gcaagtccac cgtggtgcag     3240

ctgctggaga gattctacga ccctctggca ggcaccgtgc tgctggatgg acaggaggcc     3300

aagaagctga atgtgcagtg gctgagagcc cagctgggca tcgtgtctca ggagccaatc     3360

ctgttcgatt gtagcatcgc cgagaatatc gcctacggcg acaactctag ggtggtgagc     3420

caggatgaga tcgtgagcgc cgcaaaggca gcaaacatcc acccttttat cgagaccctg     3480

ccacacaagt atgagacacg cgtgggcgac aagggcaccc agctgtccgg aggacagaag     3540

cagaggatcg caatcgcccg cgccctgatc aggcagcccc agatcctgct gctggatgaa     3600

gccacctccg ccctggacac agagtctgag aaggtggtgc aggaggccct ggacaaagcc     3660

cgcgagggac ggacatgtat tgtcattgct cacagactga gcaccatcca gaatgccgac     3720

ctgatcgtgg tgttccagaa cggcagggtg aaggagcacg gcacacacca gcagctgctg     3780

gcccagaagg gcatctactt ttctatggtg agcgtgcagg ccggcaccca gaacctgtag     3840


<210>  2
<211>  3840
<212>  DNA
<213>  artificial sequence

<220>
<223>  Codon-optimized sequence encoding MDR3 isoform A #2

<400>  2
atggatctgg aagctgccaa aaatggcaca gcttggaggc ccacctctgc tgaaggggat       60

tttgagctgg gcatcagcag caagcagaag agaaaaaaga ccaagacagt gaagatgatt      120

ggggtgctga ccctgttcag atactctgac tggcaggaca agctgttcat gagcctgggc      180

accatcatgg ccattgctca tggttctggc ctgcctctga tgatgattgt gtttggggag      240

atgacagaca agtttgtgga cacagctggc aacttcagct tccctgtgaa cttcagcctg      300

agcctgctga accctggcaa gatcctggaa gaggaaatga ccagatacgc ctactactac      360

tctggccttg gagctggtgt cctggtggct gcctatatcc aggtgtcctt ttggaccctg      420

gctgctggca gacagatcag aaagatcagg cagaaattct tccatgccat cctgaggcaa      480

gagattggat ggtttgacat caatgacacc acagagctga acaccaggct gacagatgac      540

atcagcaaga tctctgaagg cattggggac aaagtgggga tgttcttcca ggctgtggcc      600

accttctttg ctggcttcat tgtgggcttt atcagaggct ggaaactgac cctggtcatc      660

atggctatca gccccatcct gggactgtct gctgctgtgt gggccaaaat cctgtctgcc      720

ttctctgaca aagaactggc agcctatgcc aaggctggtg ctgtggctga agaagccctg      780

ggagccatca gaacagtgat tgcctttgga gggcagaaca aagagctgga aagataccag      840

aaacacctgg aaaatgccaa agagataggc atcaagaagg ccatctctgc caacatcagc      900

atgggcattg cctttctgct catctatgcc agctatgccc tggccttttg gtatggcagc      960

accctggtta tcagcaaaga gtacaccatt ggcaacgcca tgacagtgtt cttcagcatc     1020

ctgattggag ccttttctgt tggccaggct gccccttgca ttgatgcctt tgctaatgcc     1080

agaggggctg cttatgtgat ctttgacatt attgacaaca accccaagat tgacagcttc     1140

tctgagagag gccacaagcc tgacagcatc aagggcaacc ttgagttcaa tgatgtgcac     1200

ttcagctacc ccagcagggc caatgtgaaa atcctgaagg gcctgaacct gaaggtgcag     1260

tctggacaga cagtggccct tgtgggatct tctggctgtg gcaagagcac cacagtgcag     1320

ctgatccaga gactgtatga ccctgatgag ggcacaatca acattgatgg ccaggacatc     1380

agaaacttca atgtgaacta cctgagggaa atcatagggg ttgtgtccca agagcctgtg     1440

ctgttcagca ccaccattgc tgagaacatc tgctatggca ggggcaatgt cacaatggat     1500

gagatcaaga aagctgtgaa agaggccaat gcctatgagt tcatcatgaa gctgccccag     1560

aagtttgaca cccttgttgg agaaagaggg gcccagctgt ctggtggcca gaagcagaga     1620

attgccattg ccagggctct tgtcagaaac cctaagatcc tgctgctgga tgaggccaca     1680

tctgccctgg atacagagtc tgaggcagag gtgcaggctg cactggataa ggctagagag     1740

ggaagaacaa ccattgtgat tgcccacaga ctgagcacag tcagaaatgc agatgtgatt     1800

gcaggctttg aggatggggt catagtggaa cagggcagcc actctgagct gatgaagaaa     1860

gaaggggtgt acttcaagct ggtcaacatg cagaccagtg gcagccagat ccagtctgag     1920

gaatttgagc tgaatgatga gaaggctgcc accagaatgg cccctaatgg ctggaagtct     1980

aggctgttta gacacagcac ccagaagaac ctcaagaaca gccagatgtg ccagaaaagc     2040

ctggatgttg agacagatgg cctggaagcc aatgtgcctc ctgtgtcctt cctgaaagtg     2100

ctgaagctga acaagacaga gtggccctac tttgttgtgg gcacagtgtg tgccattgca     2160

aatggtggcc tgcagccagc tttctctgtg atcttctctg aaatcattgc catctttggc     2220

cctggggatg atgctgtgaa gcagcagaag tgcaatatct tttccctgat cttcctgttc     2280

ctggggatca tcagtttctt cacattcttt ctgcaaggct tcacctttgg caaggctggg     2340

gagatcctga ctagaaggct gagatctatg gccttcaaag ccatgctgag acaggacatg     2400

tcttggtttg atgaccacaa gaactccaca ggggccctga gcacaagact ggctacagat     2460

gctgctcagg tgcagggtgc tacaggcact agactggccc tgattgcaca gaacattgcc     2520

aaccttggca caggcatcat cattagcttc atctatggct ggcagctgac actgctcctg     2580

ctggctgttg tgcccatcat tgcagtgtct ggcattgtgg aaatgaagtt gctggctggc     2640

aatgccaaga gggacaagaa agagcttgag gcagcaggca agattgccac agaggccatt     2700

gagaatatca ggacagtggt gtctctgacc caagaaagaa agtttgagtc tatgtatgtg     2760

gaaaagctgt atgggcccta taggaactct gtgcaaaagg cccacatcta tgggatcacc     2820

ttctccatca gccaggcttt catgtacttt agctatgctg gctgcttcag atttggggcc     2880

tacctgattg tgaatggcca catgagattc agggatgtga tcctggtgtt ttctgccatt     2940

gtctttggag ctgtggctct gggccatgcc tctagctttg cccctgacta tgccaaagcc     3000

aaactgtctg cagcccacct gttcatgctg tttgagagac agcccctgat tgactcctac     3060

tctgaggaag gactgaagcc tgataagttt gagggcaaca tcaccttcaa tgaggtggtg     3120

ttcaactacc ctaccagagc taatgtgcca gtgctgcagg gactctccct ggaagtgaag     3180

aaagggcaga ctctggctct tgtgggcagc tcaggatgtg gcaagtctac agtggtgcag     3240

ctgctggaaa ggttctatga tcccctggca ggcacagtgc tgttggatgg ccaagaggct     3300

aaaaagctga atgtgcagtg gctgagagca cagctgggaa ttgtgtctca agaacccatc     3360

ctgtttgact gcagcatagc agagaacata gcctatgggg acaactccag agtggtttct     3420

caggatgaga ttgtctctgc tgccaaggca gccaacattc accccttcat tgagacactg     3480

ccccacaaat atgagacaag agtgggagac aagggaaccc agctcagtgg tggacagaaa     3540

caaaggattg ctatagctag ggccctgatc agacagcctc agattctgct ccttgatgaa     3600

gcaacctctg ctctggacac tgaatctgag aaggtggtgc aagaggccct ggacaaagcc     3660

agagagggta gaacctgcat tgtcattgct cacaggctgt ctaccatcca gaatgctgat     3720

ctgattgtgg tgttccagaa tgggagagtg aaagagcatg gcacccacca gcaactgctg     3780

gcccagaagg gcatctactt cagcatggtg tctgtgcagg cagggaccca gaacctgtaa     3840


<210>  3
<211>  56
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic poly A sequence

<400>  3
aataaagacc tcttattttc attcatcagg tgtggttggt ttttttgtgt gggggc           56


<210>  4
<211>  4598
<212>  DNA
<213>  artificial sequence

<220>
<223>  recombinant AAV vector comprising codon-optimized sequence 
       encoding MDR3 isoform A

<400>  4
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgcg aattccatgg taccaggcat caagacacgt      180

gcgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      240

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      300

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      360

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      420

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      480

agtgaaggcc tgtcgacgga tccgccgcca ccatggatct ggaggccgcc aagaacggca      540

ccgcctggag acccacaagc gccgagggcg acttcgagct gggcatcagc tccaagcaga      600

agagaaagaa gaccaagaca gtgaagatga tcggcgtgct gacactgttc aggtactccg      660

actggcagga taagctgttt atgtctctgg gcaccatcat ggcaatcgcc cacggcagcg      720

gcctgcctct gatgatgatc gtgttcggcg agatgaccga caagtttgtg gatacagccg      780

gcaatttctc ctttcccgtg aacttctctc tgagcctgct gaaccctggc aagatcctgg      840

aggaggagat gacaagatat gcctactatt actctggcct gggagcaggc gtgctggtgg      900

cagcatacat ccaggtgagc ttctggaccc tggcagcagg ccggcagatc agaaagatca      960

ggcagaagtt ctttcacgcc atcctgcgcc aggagatcgg ctggtttgac atcaatgata     1020

ccacagagct gaacacccgg ctgacagacg acatctctaa gatcagcgag ggcatcggcg     1080

ataaagtggg catgttcttt caggccgtgg ccacattctt tgccggcttc atcgtgggct     1140

ttatcagggg ctggaagctg accctggtca tcatggccat ctctccaatc ctgggcctga     1200

gcgccgccgt gtgggcaaag atcctgtccg ccttctctga caaggagctg gccgcctacg     1260

ccaaggcagg agcagtggca gaggaggccc tgggcgccat ccgcaccgtg atcgcctttg     1320

gcggccagaa taaggagctg gagcggtatc agaagcacct ggagaacgcc aaggagatcg     1380

gcatcaagaa ggccatctcc gccaatatct ctatgggcat cgccttcctg ctgatctatg     1440

ccagctacgc cctggccttt tggtatggca gcaccctggt catcagcaag gagtacacca     1500

tcggcaatgc catgacagtg ttctttagca tcctgatcgg agccttctcc gtgggacagg     1560

cagcaccatg catcgacgcc ttcgccaacg ccagaggcgc agcctacgtg atctttgaca     1620

tcatcgataa caatccaaag atcgactcct tttctgagcg gggccacaag cccgattcca     1680

tcaagggcaa tctggagttc aacgacgtgc actttagcta tccctcccgc gccaatgtga     1740

agatcctgaa gggcctgaac ctgaaggtgc agtccggaca gacagtggcc ctggtgggct     1800

ctagcggatg cggcaagtct accacagtgc agctgatcca gcggctgtat gacccagatg     1860

agggcaccat caacatcgac ggccaggaca tccgcaactt caatgtgaac tacctgcggg     1920

agatcatcgg cgtggtgtct caggagcccg tgctgtttag caccacaatc gccgagaata     1980

tctgttatgg ccgcggcaac gtgacaatgg atgagatcaa gaaggccgtg aaggaggcca     2040

atgcctacga gttcatcatg aagctgcccc agaagtttga caccctggtg ggagagagag     2100

gcgcccagct gagcggaggc cagaagcaga ggatcgccat cgccagagcc ctggtgagga     2160

accctaagat cctgctgctg gacgaggcca cctccgccct ggatacagag tctgaggcag     2220

aggtgcaggc cgccctggat aaggcccgcg agggacggac cacaatcgtg atcgcccaca     2280

gactgagcac agtgaggaat gccgacgtga tcgccggctt cgaggatggc gtgatcgtgg     2340

agcagggcag ccactccgag ctgatgaaga aggagggcgt gtacttcaag ctggtgaaca     2400

tgcagacctc tggcagccag atccagtccg aggagtttga gctgaatgac gagaaggcag     2460

caacaaggat ggcacctaac ggatggaaga gcagactgtt caggcactcc acccagaaga     2520

atctgaagaa ctctcagatg tgccagaaga gcctggacgt ggaaaccgat ggactggagg     2580

caaatgtgcc acccgtgagc ttcctgaagg tgctgaagct gaacaagaca gagtggccat     2640

attttgtggt gggcaccgtg tgcgcaatcg caaatggcgg cctgcagcca gccttcagcg     2700

tgatcttttc cgagatcatc gccatcttcg gccctggcga cgatgccgtg aagcagcaga     2760

agtgtaacat cttttccctg atcttcctgt ttctgggcat catctctttc tttaccttct     2820

ttctgcaggg cttcacattt ggcaaggccg gcgagatcct gacacggaga ctgagaagca     2880

tggccttcaa ggccatgctg aggcaggata tgtcctggtt tgacgatcac aagaacagca     2940

ccggcgccct gtccaccaga ctggcaacag acgcagcaca ggtgcaggga gcaaccggca     3000

caaggctggc cctgatcgcc cagaatatcg ccaacctggg cacaggcatc atcatctctt     3060

tcatctacgg ctggcagctg accctgctgc tgctggcagt ggtgccaatc atcgccgtga     3120

gcggcatcgt ggagatgaag ctgctggccg gcaatgccaa gagagacaag aaggagctgg     3180

aggcagcagg caagatcgca accgaggcca tcgagaacat ccgcaccgtg gtgagcctga     3240

cacaggagcg gaagttcgag tccatgtatg tggagaagct gtatggccct taccgcaatt     3300

ccgtgcagaa ggcccacatc tacggcatca ccttttccat ctctcaggct ttcatgtatt     3360

tttcttacgc cggctgcttc cggtttggcg cctatctgat cgtgaacggc cacatgaggt     3420

tccgcgatgt gatcctggtg ttctctgcca tcgtgtttgg agcagtggcc ctgggacacg     3480

cctcctcttt tgcccctgac tatgcaaagg caaagctgtc cgccgcacac ctgttcatgc     3540

tgtttgagag acagcctctg atcgatagct actccgagga gggcctgaag ccagacaagt     3600

tcgagggcaa tatcacattc aacgaggtgg tgtttaatta tccaaccagg gccaacgtgc     3660

ccgtgctgca gggcctgagc ctggaggtga agaagggaca gacactggcc ctggtgggca     3720

gctccggatg cggcaagtcc accgtggtgc agctgctgga gagattctac gaccctctgg     3780

caggcaccgt gctgctggat ggacaggagg ccaagaagct gaatgtgcag tggctgagag     3840

cccagctggg catcgtgtct caggagccaa tcctgttcga ttgtagcatc gccgagaata     3900

tcgcctacgg cgacaactct agggtggtga gccaggatga gatcgtgagc gccgcaaagg     3960

cagcaaacat ccaccctttt atcgagaccc tgccacacaa gtatgagaca cgcgtgggcg     4020

acaagggcac ccagctgtcc ggaggacaga agcagaggat cgcaatcgcc cgcgccctga     4080

tcaggcagcc ccagatcctg ctgctggatg aagccacctc cgccctggac acagagtctg     4140

agaaggtggt gcaggaggcc ctggacaaag cccgcgaggg acggacatgt attgtcattg     4200

ctcacagact gagcaccatc cagaatgccg acctgatcgt ggtgttccag aacggcaggg     4260

tgaaggagca cggcacacac cagcagctgc tggcccagaa gggcatctac ttttctatgg     4320

tgagcgtgca ggccggcacc cagaacctgt agcatatgat atcaataaag acctcttatt     4380

ttcattcatc aggtgtggtt ggtttttttg tgtgggggct cgagatctga ggaaccccta     4440

gtgatggagg cggccgcagg aacccctagt gatggagttg gccactccct ctctgcgcgc     4500

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     4560

ggcctcagtg agcgagcgag cgcgcagctg cctgcagg                             4598


<210>  5
<211>  4598
<212>  DNA
<213>  artificial sequence

<220>
<223>  recombinant AAv vector comprising codon-optimized sequence 
       encoding MDR3 isoform A #2

<400>  5
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgcg aattccatgg taccaggcat caagacacgt      180

gcgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      240

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      300

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      360

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      420

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      480

agtgaaggcc tgtcgacgga tccgccgcca ccatggatct ggaagctgcc aaaaatggca      540

cagcttggag gcccacctct gctgaagggg attttgagct gggcatcagc agcaagcaga      600

agagaaaaaa gaccaagaca gtgaagatga ttggggtgct gaccctgttc agatactctg      660

actggcagga caagctgttc atgagcctgg gcaccatcat ggccattgct catggttctg      720

gcctgcctct gatgatgatt gtgtttgggg agatgacaga caagtttgtg gacacagctg      780

gcaacttcag cttccctgtg aacttcagcc tgagcctgct gaaccctggc aagatcctgg      840

aagaggaaat gaccagatac gcctactact actctggcct tggagctggt gtcctggtgg      900

ctgcctatat ccaggtgtcc ttttggaccc tggctgctgg cagacagatc agaaagatca      960

ggcagaaatt cttccatgcc atcctgaggc aagagattgg atggtttgac atcaatgaca     1020

ccacagagct gaacaccagg ctgacagatg acatcagcaa gatctctgaa ggcattgggg     1080

acaaagtggg gatgttcttc caggctgtgg ccaccttctt tgctggcttc attgtgggct     1140

ttatcagagg ctggaaactg accctggtca tcatggctat cagccccatc ctgggactgt     1200

ctgctgctgt gtgggccaaa atcctgtctg ccttctctga caaagaactg gcagcctatg     1260

ccaaggctgg tgctgtggct gaagaagccc tgggagccat cagaacagtg attgcctttg     1320

gagggcagaa caaagagctg gaaagatacc agaaacacct ggaaaatgcc aaagagatag     1380

gcatcaagaa ggccatctct gccaacatca gcatgggcat tgcctttctg ctcatctatg     1440

ccagctatgc cctggccttt tggtatggca gcaccctggt tatcagcaaa gagtacacca     1500

ttggcaacgc catgacagtg ttcttcagca tcctgattgg agccttttct gttggccagg     1560

ctgccccttg cattgatgcc tttgctaatg ccagaggggc tgcttatgtg atctttgaca     1620

ttattgacaa caaccccaag attgacagct tctctgagag aggccacaag cctgacagca     1680

tcaagggcaa ccttgagttc aatgatgtgc acttcagcta ccccagcagg gccaatgtga     1740

aaatcctgaa gggcctgaac ctgaaggtgc agtctggaca gacagtggcc cttgtgggat     1800

cttctggctg tggcaagagc accacagtgc agctgatcca gagactgtat gaccctgatg     1860

agggcacaat caacattgat ggccaggaca tcagaaactt caatgtgaac tacctgaggg     1920

aaatcatagg ggttgtgtcc caagagcctg tgctgttcag caccaccatt gctgagaaca     1980

tctgctatgg caggggcaat gtcacaatgg atgagatcaa gaaagctgtg aaagaggcca     2040

atgcctatga gttcatcatg aagctgcccc agaagtttga cacccttgtt ggagaaagag     2100

gggcccagct gtctggtggc cagaagcaga gaattgccat tgccagggct cttgtcagaa     2160

accctaagat cctgctgctg gatgaggcca catctgccct ggatacagag tctgaggcag     2220

aggtgcaggc tgcactggat aaggctagag agggaagaac aaccattgtg attgcccaca     2280

gactgagcac agtcagaaat gcagatgtga ttgcaggctt tgaggatggg gtcatagtgg     2340

aacagggcag ccactctgag ctgatgaaga aagaaggggt gtacttcaag ctggtcaaca     2400

tgcagaccag tggcagccag atccagtctg aggaatttga gctgaatgat gagaaggctg     2460

ccaccagaat ggcccctaat ggctggaagt ctaggctgtt tagacacagc acccagaaga     2520

acctcaagaa cagccagatg tgccagaaaa gcctggatgt tgagacagat ggcctggaag     2580

ccaatgtgcc tcctgtgtcc ttcctgaaag tgctgaagct gaacaagaca gagtggccct     2640

actttgttgt gggcacagtg tgtgccattg caaatggtgg cctgcagcca gctttctctg     2700

tgatcttctc tgaaatcatt gccatctttg gccctgggga tgatgctgtg aagcagcaga     2760

agtgcaatat cttttccctg atcttcctgt tcctggggat catcagtttc ttcacattct     2820

ttctgcaagg cttcaccttt ggcaaggctg gggagatcct gactagaagg ctgagatcta     2880

tggccttcaa agccatgctg agacaggaca tgtcttggtt tgatgaccac aagaactcca     2940

caggggccct gagcacaaga ctggctacag atgctgctca ggtgcagggt gctacaggca     3000

ctagactggc cctgattgca cagaacattg ccaaccttgg cacaggcatc atcattagct     3060

tcatctatgg ctggcagctg acactgctcc tgctggctgt tgtgcccatc attgcagtgt     3120

ctggcattgt ggaaatgaag ttgctggctg gcaatgccaa gagggacaag aaagagcttg     3180

aggcagcagg caagattgcc acagaggcca ttgagaatat caggacagtg gtgtctctga     3240

cccaagaaag aaagtttgag tctatgtatg tggaaaagct gtatgggccc tataggaact     3300

ctgtgcaaaa ggcccacatc tatgggatca ccttctccat cagccaggct ttcatgtact     3360

ttagctatgc tggctgcttc agatttgggg cctacctgat tgtgaatggc cacatgagat     3420

tcagggatgt gatcctggtg ttttctgcca ttgtctttgg agctgtggct ctgggccatg     3480

cctctagctt tgcccctgac tatgccaaag ccaaactgtc tgcagcccac ctgttcatgc     3540

tgtttgagag acagcccctg attgactcct actctgagga aggactgaag cctgataagt     3600

ttgagggcaa catcaccttc aatgaggtgg tgttcaacta ccctaccaga gctaatgtgc     3660

cagtgctgca gggactctcc ctggaagtga agaaagggca gactctggct cttgtgggca     3720

gctcaggatg tggcaagtct acagtggtgc agctgctgga aaggttctat gatcccctgg     3780

caggcacagt gctgttggat ggccaagagg ctaaaaagct gaatgtgcag tggctgagag     3840

cacagctggg aattgtgtct caagaaccca tcctgtttga ctgcagcata gcagagaaca     3900

tagcctatgg ggacaactcc agagtggttt ctcaggatga gattgtctct gctgccaagg     3960

cagccaacat tcaccccttc attgagacac tgccccacaa atatgagaca agagtgggag     4020

acaagggaac ccagctcagt ggtggacaga aacaaaggat tgctatagct agggccctga     4080

tcagacagcc tcagattctg ctccttgatg aagcaacctc tgctctggac actgaatctg     4140

agaaggtggt gcaagaggcc ctggacaaag ccagagaggg tagaacctgc attgtcattg     4200

ctcacaggct gtctaccatc cagaatgctg atctgattgt ggtgttccag aatgggagag     4260

tgaaagagca tggcacccac cagcaactgc tggcccagaa gggcatctac ttcagcatgg     4320

tgtctgtgca ggcagggacc cagaacctgt aacatatgat atcaataaag acctcttatt     4380

ttcattcatc aggtgtggtt ggtttttttg tgtgggggct cgagatctga ggaaccccta     4440

gtgatggagg cggccgcagg aacccctagt gatggagttg gccactccct ctctgcgcgc     4500

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     4560

ggcctcagtg agcgagcgag cgcgcagctg cctgcagg                             4598


<210>  6
<211>  255
<212>  DNA
<213>  artificial sequence

<220>
<223>  Alpha 1 antitrypsin promoter

<400>  6
cgccaccccc tccaccttgg acacaggacg ctgtggtttc tgagccaggt acaatgactc       60

ctttcggtaa gtgcagtgga agctgtacac tgcccaggca aagcgtccgg gcagcgtagg      120

cgggcgactc agatcccagc cagtggactt agcccctgtt tgctcctccg ataactgggg      180

tgaccttggt taatattcac cagcagcctc ccccgttgcc cctctggatc cactgcttaa      240

atacggacga ggaca                                                       255


<210>  7
<211>  145
<212>  DNA
<213>  artificial sequence

<220>
<223>  Human minimal bile salt export pump (ABCB11) gene promoter

<400>  7
ttcccaagca cactctgtgt ttggggttat tgctctgagt atgtttctcg tatgtcactg       60

aactgtgctt gggctgccct tagggacatt gatccttagg caaatagata atgttcttga      120

aaaagtttga attctgttca gtgct                                            145


<210>  8
<211>  145
<212>  DNA
<213>  artificial sequence

<220>
<223>  Mouse minimal Bile Salt export pump (ABCB11) gene promoter

<400>  8
ggttcctgct ttgagtatgt tcgacctttc ctctcatgtc actgaactgt gctagatctg       60

gactttaggc cattgaccta taagcaaata gatagtgttc ttaaaaaagc ctgatttctg      120

ttcaatgctt tattaccatg aaaac                                            145


<210>  9
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Forward alpha-1-anti-trypsin promoter primer

<400>  9
ttgctcctcc gataactggg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Reverse alpha-1-anti-trypsin promoter primer

<400>  10
ccctgtcctc gtccgtattt                                                   20


