                         SEQUENCE LISTING

<110>  Numab Therapeutics AG
 
<120>  ANTIBODIES TARGETING CD137 AND METHODS OF USE THEREOF

<130>  115159P877PC

<150>  EP18199334.6
<151>  2018-10-09

<150>  EP19166283.2
<151>  2019-03-29

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  1

Gly Phe Ser Phe Ser Ala Asn Tyr Tyr Pro Cys 
1               5                   10      


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  2

Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn Trp Thr 
1               5                   10                  15      


Lys 
    


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  3

Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu 
1               5                   10          


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  4

Ala Ser Gly Phe Ser Phe Ser Ala Asn Tyr Tyr 
1               5                   10      


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  5

Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn Trp Thr Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  6

Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp 
1               5                   10  


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  7

Ala Asn Tyr Tyr Pro Cys 
1               5       


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  8

Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn Trp Thr 
1               5                   10                  15      


Lys 
    


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  9

Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu 
1               5                   10      


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  10

Gly Phe Ser Phe Ser Ala Asn Tyr 
1               5               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  11

Gly Gly Ser Ser 
1               


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  12

Ala Trp Tyr Ser Gly Trp Gly Gly Asp 
1               5                   


<210>  13
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn 
    50                  55                  60                  


Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  14

Glu Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn 
    50                  55                  60                  


Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn 
    50                  55                  60                  


Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  16

Gln Ala Ser Gln Ser Ile Ser Asn Arg Leu Ala 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  17

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  18

Gln Ser Thr Tyr Tyr Gly Asn Asp Gly Asn Ala 
1               5                   10      


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  19

Ala Ser Gln Ser Ile Ser Asn Arg 
1               5               


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  20

Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
1               5                   10          


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  21

Thr Tyr Tyr Gly Asn Asp Gly Asn 
1               5               


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  22

Ser Gln Ser Ile Ser Asn Arg 
1               5           


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  23

Ser Ala Ser 
1           


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  24

Thr Tyr Tyr Gly Asn Asp Gly Asn 
1               5               


<210>  25
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110 


<210>  26
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  26

Asp Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110 


<210>  27
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110 


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  28

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  29
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
145                 150                 155                 160 


Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp 
            180                 185                 190         


Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  30
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  30

Asp Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
145                 150                 155                 160 


Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp 
            180                 185                 190         


Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Phe Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp 
225                 230                 235                 240 


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  31
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
145                 150                 155                 160 


Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp 
            180                 185                 190         


Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  32
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  33
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  33

Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  34

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  35
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  35

Phe Gly Gly Gly Thr Gln Leu Ile Ile Leu Gly 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  36

Phe Gly Glu Gly Thr Glu Leu Thr Val Leu Gly 
1               5                   10      


<210>  37
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  37

Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  38

Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  39

Phe Gly Gly Gly Thr Gln Leu Thr Ala Leu Gly 
1               5                   10      


<210>  40
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser 
                165                 170                 175     


Asp Ile Thr Tyr Asp Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Trp Tyr Ser 
    210                 215                 220                 


Gly Trp Gly Gly Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            260                 265                 270         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 
        275                 280                 285             


Ile Ser Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    290                 295                 300                 


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 
305                 310                 315                 320 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                325                 330                 335     


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr 
            340                 345                 350         


Tyr Gly Asn Asp Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Ala Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    450                 455                 460                 


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met 
            660                 665                 670         


Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile 
        675                 680                 685             


Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
                725                 730                 735     


Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  41
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Ser Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser 
                165                 170                 175     


Asp Ile Thr Tyr Asp Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Ser Ala Trp Tyr Ser 
    210                 215                 220                 


Gly Trp Gly Gly Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            260                 265                 270         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 
        275                 280                 285             


Ile Ser Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro 
    290                 295                 300                 


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 
305                 310                 315                 320 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                325                 330                 335     


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr 
            340                 345                 350         


Tyr Gly Asn Asp Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Ala Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    450                 455                 460                 


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met 
            660                 665                 670         


Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile 
        675                 680                 685             


Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
                725                 730                 735     


Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  42
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Cys Leu Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser 
                165                 170                 175     


Asp Ile Thr Tyr Asp Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Trp Tyr Ser 
    210                 215                 220                 


Gly Trp Gly Gly Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            260                 265                 270         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 
        275                 280                 285             


Ile Ser Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    290                 295                 300                 


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 
305                 310                 315                 320 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                325                 330                 335     


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr 
            340                 345                 350         


Tyr Gly Asn Asp Gly Asn Ala Phe Gly Cys Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Ala Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    450                 455                 460                 


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met 
            660                 665                 670         


Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile 
        675                 680                 685             


Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
                725                 730                 735     


Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  43
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
        115                 120                 125             


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Asn Ser Tyr Trp Ile Cys Trp Ile Arg Gln Pro 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser 
                165                 170                 175     


Asp Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser 
            180                 185                 190         


Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala 
    210                 215                 220                 


Val Tyr Gly Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            260                 265                 270         


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 
        275                 280                 285             


Ser Gln Ser Ile Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    290                 295                 300                 


Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly 
305                 310                 315                 320 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                325                 330                 335     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            340                 345                 350         


Ser Ser Tyr Gly Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr 
        355                 360                 365             


Val Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly 
    370                 375                 380                 


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val 
385                 390                 395                 400 


Ser Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Ile Arg Gln 
                405                 410                 415     


Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Gly Gly Ser 
            420                 425                 430         


Ser Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Val Thr Ile 
        435                 440                 445             


Ser Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Val Asp 
465                 470                 475                 480 


Tyr Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Val Met Thr 
            500                 505                 510         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        515                 520                 525             


Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg Ser Ala Trp Tyr Gln 
    530                 535                 540                 


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser Lys 
545                 550                 555                 560 


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                565                 570                 575     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            580                 585                 590         


Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn Phe Gly Ala Phe Gly 
        595                 600                 605             


Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
625                 630                 635                 640 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                645                 650                 655     


Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr Trp Ile 
            660                 665                 670         


Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Cys 
        675                 680                 685             


Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    690                 695                 700                 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
705                 710                 715                 720 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                725                 730                 735     


Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu Trp Gly Gln Gly Thr 
            740                 745                 750         


Leu Val Thr Val Ser Ser 
        755             


<210>  44
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
            180                 185                 190         


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Gly Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490             


<210>  45
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial construct comprising CD137 extracellular domain(s)

<400>  45

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe 
            20                  25                  30          


Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser 
        35                  40                  45              


Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys 
    50                  55                  60                  


Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala 
65                  70                  75                  80  


Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser 
                85                  90                  95      


Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly 
            100                 105                 110         


Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile 
        115                 120                 125             


Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val 
    130                 135                 140                 


Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp 
145                 150                 155                 160 


Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu 
                165                 170                 175     


Pro Gly His Ser Pro Gln Leu Glu Val Leu Phe Gln Gly Pro Leu Glu 
            180                 185                 190         


Val Leu Phe Gln Gly Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        195                 200                 205             


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    210                 215                 220                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
225                 230                 235                 240 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                245                 250                 255     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            260                 265                 270         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        275                 280                 285             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    290                 295                 300                 


Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425 


<210>  46
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial construct comprising CD137 extracellular domain(s)

<400>  46

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe 
            20                  25                  30          


Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Leu Glu Val Leu Phe Gln 
        35                  40                  45              


Gly Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
    50                  55                  60                  


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
65                  70                  75                  80  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                85                  90                  95      


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            100                 105                 110         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        115                 120                 125             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    130                 135                 140                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala 
145                 150                 155                 160 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                165                 170                 175     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            180                 185                 190         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        195                 200                 205             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    210                 215                 220                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
225                 230                 235                 240 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                245                 250                 255     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            260                 265                 270         


Leu Ser Pro Gly Lys 
        275         


<210>  47
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial construct comprising CD137 extracellular domain(s)

<400>  47

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe 
            20                  25                  30          


Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser 
        35                  40                  45              


Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys 
    50                  55                  60                  


Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala 
65                  70                  75                  80  


Glu Cys Leu Glu Val Leu Phe Gln Gly Pro Asp Lys Thr His Thr Cys 
                85                  90                  95      


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            100                 105                 110         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        115                 120                 125             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    130                 135                 140                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
145                 150                 155                 160 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                165                 170                 175     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            180                 185                 190         


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        195                 200                 205             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    210                 215                 220                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
225                 230                 235                 240 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                245                 250                 255     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            260                 265                 270         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        275                 280                 285             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    290                 295                 300                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
305                 310                 315         


<210>  48
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial construct comprising CD137 extracellular domain(s)

<400>  48

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe 
            20                  25                  30          


Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser 
        35                  40                  45              


Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys 
    50                  55                  60                  


Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala 
65                  70                  75                  80  


Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser 
                85                  90                  95      


Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly 
            100                 105                 110         


Cys Lys Leu Glu Val Leu Phe Gln Gly Pro Asp Lys Thr His Thr Cys 
        115                 120                 125             


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
    130                 135                 140                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
145                 150                 155                 160 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                165                 170                 175     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            180                 185                 190         


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        195                 200                 205             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    210                 215                 220                 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
225                 230                 235                 240 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                245                 250                 255     


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            260                 265                 270         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        275                 280                 285             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    290                 295                 300                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
305                 310                 315                 320 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                325                 330                 335     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 


<210>  49
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial construct comprising CD137 extracellular domain(s)

<400>  49

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln 
            20                  25                  30          


Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg 
        35                  40                  45              


Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly 
    50                  55                  60                  


Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys 
65                  70                  75                  80  


Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly 
                85                  90                  95      


Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys 
            100                 105                 110         


Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp 
        115                 120                 125             


Val Val Cys Gly Pro Leu Glu Val Leu Phe Gln Gly Pro Asp Lys Thr 
    130                 135                 140                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
145                 150                 155                 160 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                165                 170                 175     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            180                 185                 190         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        195                 200                 205             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    210                 215                 220                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
225                 230                 235                 240 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                245                 250                 255     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            260                 265                 270         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        275                 280                 285             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    290                 295                 300                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
305                 310                 315                 320 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                325                 330                 335     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            340                 345                 350         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 365             


<210>  50
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial construct comprising CD137 extracellular domain(s)

<400>  50

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys 
            20                  25                  30          


Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys 
        35                  40                  45              


Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly 
    50                  55                  60                  


Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu 
65                  70                  75                  80  


Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro Leu Glu Val 
                85                  90                  95      


Leu Phe Gln Gly Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            100                 105                 110         


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    130                 135                 140                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
145                 150                 155                 160 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                165                 170                 175     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            180                 185                 190         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        195                 200                 205             


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    210                 215                 220                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
225                 230                 235                 240 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                245                 250                 255     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            260                 265                 270         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        275                 280                 285             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    290                 295                 300                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
305                 310                 315                 320 


Ser Leu Ser Leu Ser Pro Gly Lys 
                325             


<210>  51
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial construct comprising CD137 extracellular domain(s)

<400>  51

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly 
            20                  25                  30          


Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu 
        35                  40                  45              


Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro Leu Glu Val 
    50                  55                  60                  


Leu Phe Gln Gly Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
65                  70                  75                  80  


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                85                  90                  95      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            100                 105                 110         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        115                 120                 125             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    130                 135                 140                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
145                 150                 155                 160 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                165                 170                 175     


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            180                 185                 190         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        195                 200                 205             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    210                 215                 220                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
225                 230                 235                 240 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                245                 250                 255     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            260                 265                 270         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        275                 280                 285             


Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295     


<210>  52
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial construct comprising CD137 extracellular domain(s)

<400>  52

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln 
            20                  25                  30          


Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg 
        35                  40                  45              


Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly 
    50                  55                  60                  


Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys 
65                  70                  75                  80  


Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Leu Glu Val Leu Phe 
                85                  90                  95      


Gln Gly Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            100                 105                 110         


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                165                 170                 175     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


