                         SEQUENCE LISTING

<110>  Oregon Health & Science University
       United States Government as Represented by the Department 
       of Veterans Affairs
       Meza-Romero, Roberto
       Vandenbark, Arthur A.
       Offner, Halina
 
<120>  RECOMBINANT POLYPEPTIDES COMPRISING MODIFIED MHC CLASS II DRa1 
       DOMAINS AND METHODS OF USE

<130>  899-101380-02

<150>  US 62/741,941
<151>  2018-10-05

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified DRalpha1 polypeptide

<400>  1

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Gln Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn 
                


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRhQ polypeptide

<400>  2

Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
        35                  40                  45              


Tyr Gln Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly 
    50                  55                  60                  


Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg 
65                  70                  75                  80  


Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu 
                85                  90                  95      


Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg 
            100                 105                 110         


Ser Asn Tyr Thr Pro Ile Thr Asn 
        115                 120 


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRmQ polypeptide

<400>  3

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
        35                  40                  45              


Tyr Gln Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly 
    50                  55                  60                  


Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg 
65                  70                  75                  80  


Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu 
                85                  90                  95      


Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg 
            100                 105                 110         


Ser Asn Tyr Thr Pro Ile Thr Asn 
        115                 120 


<210>  4
<211>  242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleiic acid encoding modified DRalpha1 polypeptide

<400>  4
atcaaagaag aacatgtgat catccaggcc gagttctatc agaatcctga ccaatcaggc       60

gagtttatgt ttgactttga tggtgatgag attttccatg tggatatggc aaagaaggag      120

acggtctggc ggcttgaaga atttggacga tttgccagct ttgaggctca aggtgcattg      180

gccaacatag ctgtggacaa agccaacttg gaaatcatga caaagcgctc caactatact      240

cc                                                                     242


<210>  5
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding DRhQ

<400>  5
atggaagttg gttggtaccg tccgccgttc tcccgtgttg ttcacctgta ccgtaacggt       60

aaaggaggtg gaggctcact agtgccccga ggctctggag gtggaggcat caaagaagaa      120

catgtgatca tccaggccga gttctatcag aatcctgacc aatcaggcga gtttatgttt      180

gactttgatg gtgatgagat tttccatgtg gatatggcaa agaaggagac ggtctggcgg      240

cttgaagaat ttggacgatt tgccagcttt gaggctcaag gtgcattggc caacatagct      300

gtggacaaag ccaacttgga aatcatgaca aagcgctcca actatactcc gatcaccaat      360

taa                                                                    363


<210>  6
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding DRmQ

<400>  6
atggaagttg gttggtaccg ttccccgttc tcccgtgttg ttcacctgta ccgtaacggt       60

aaaggaggtg gaggctcact agtgccccga ggctctggag gtggaggcat caaagaagaa      120

catgtgatca tccaggccga gttctatcaa aatcctgacc aatcaggcga gtttatgttt      180

gactttgatg gtgatgagat tttccatgtg gatatggcaa agaaggagac ggtctggcgg      240

cttgaagaat ttggacgatt tgccagcttt gaggctcaag gtgcattggc caacatagct      300

gtggacaaag ccaacttgga aatcatgaca aagcgctcca actatactcc gatcaccaat      360

taa                                                                    363


<210>  7
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human DM1 alpha 1 domain

<400>  7

Trp Pro Asp Asp Leu Gln Asn His Thr Phe Leu His Thr Val Tyr Cys 
1               5                   10                  15      


Gln Asp Gly Ser Pro Ser Val Gly Leu Ser Glu Ala Tyr Asp Glu Asp 
            20                  25                  30          


Gln Leu Phe Phe Phe Asp Phe Ser Gln Asn Thr Arg Val Pro Arg Leu 
        35                  40                  45              


Pro Glu Phe Ala Asp Trp Ala Gln Glu Gln Gly 
    50                  55                  


<210>  8
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DO1 alpha1 domain

<400>  8

Ala Gly Ala Thr Lys Ala Asp His Met Gly Ser Tyr Gly Pro Ala Phe 
1               5                   10                  15      


Tyr Gln Ser Tyr Gly Ala Ser Gly Gln Phe Thr His Glu Phe Asp Glu 
            20                  25                  30          


Glu Gln Leu Phe Ser Val Asp Leu Lys Lys Ser Glu Ala Val Trp Arg 
        35                  40                  45              


Leu Pro Glu Phe Gly Asp Phe Ala Arg Phe Asp Pro 
    50                  55                  60  


<210>  9
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DQ1 alpha1 domain

<400>  9

Gly Glu Asp Ile Val Ala Asp His Val Ala Ser Cys Gly Val Asn Leu 
1               5                   10                  15      


Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly 
            20                  25                  30          


Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg Lys Glu Thr Ala Trp Arg 
        35                  40                  45              


Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe Asp Pro 
    50                  55                  60  


<210>  10
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DQ2 alpha1 domain

<400>  10

Gly Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Phe 
1               5                   10                  15      


Tyr Gln Ser His Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly 
            20                  25                  30          


Asp Glu Glu Phe Tyr Val Asp Leu Glu Thr Lys Glu Thr Val Trp Gln 
        35                  40                  45              


Leu Pro Met Phe Ser Lys Phe Ile Ser Phe Asp Pro 
    50                  55                  60  


<210>  11
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DP4 alpha1 domain

<400>  11

Arg Arg Val Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val 
1               5                   10                  15      


Gln Thr His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp 
            20                  25                  30          


Glu Met Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu 
        35                  40                  45              


Glu Glu Phe Gly Gln Ala Phe Ser Phe Glu Ala 
    50                  55                  


<210>  12
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DP2 alpha1 domain

<400>  12

Ala Gly Ala Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val 
1               5                   10                  15      


Gln Thr His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp 
            20                  25                  30          


Glu Met Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu 
        35                  40                  45              


Glu Glu Phe Gly Gln Ala Phe Ser Phe Glu Ala 
    50                  55                  


<210>  13
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DR1 alpha1 domain

<400>  13

Ala Gly Ala Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val 
1               5                   10                  15      


Gln Thr His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp 
            20                  25                  30          


Glu Met Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu 
        35                  40                  45              


Glu Glu Phe Gly Gln Ala Phe Ser Phe Glu Ala 
    50                  55                  


<210>  14
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse IAk alpha 1 domain

<400>  14

Glu Asp Asp Ile Glu Ala Asp His Val Gly Ser Tyr Gly Ile Thr Val 
1               5                   10                  15      


Tyr Gln Ser Pro Gly Asp Ile Gly Gln Tyr Thr Phe Glu Phe Asp Gly 
            20                  25                  30          


Asp Glu Leu Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp Met 
        35                  40                  45              


Leu Pro Glu Phe Ala Gln Leu Arg Arg Phe Glu Pro 
    50                  55                  60  


<210>  15
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse IAd alpha1 domain

<400>  15

Glu Asp Asp Ile Glu Ala Asp His Val Gly Phe Tyr Gly Thr Thr Val 
1               5                   10                  15      


Tyr Gln Ser Pro Gly Asp Ile Gly Gln Tyr Thr His Glu Phe Asp Gly 
            20                  25                  30          


Asp Glu Leu Phe Tyr Val Asp Leu Asp Lys Lys Lys Thr Val Trp Arg 
        35                  40                  45              


Leu Pro Glu Phe Gly Gln Leu Ile Leu Phe Glu Pro 
    50                  55                  60  


<210>  16
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse IAb alpha1 domain

<400>  16

Glu Asp Asp Ile Glu Ala Asp His Val Gly Thr Tyr Gly Thr Ser Val 
1               5                   10                  15      


Tyr Gln Ser Pro Gly Asp Ile Gly Gln Tyr Thr Phe Glu Phe Asp Gly 
            20                  25                  30          


Asp Glu Leu Phe Tyr Val Asp Leu Asp Lys Lys Lys Thr Val Trp Arg 
        35                  40                  45              


Leu Pro Glu Phe Gly Gln Leu Ala Ser Phe Asp Pro 
    50                  55                  60  


<210>  17
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse IAf alpha1 domain

<400>  17

Glu Asp Asp Ile Glu Ala Asp His Val Gly Phe Tyr Gly Ile Ser Val 
1               5                   10                  15      


Tyr Gln Ser Pro Gly Asp Ile Gly Gln Tyr Thr Phe Glu Phe Asp Gly 
            20                  25                  30          


Asp Glu Trp Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp Arg 
        35                  40                  45              


Leu Pro Glu Phe Gly Gln Leu Thr Ser Phe Asp Pro 
    50                  55                  60  


<210>  18
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse IAu alpha1 domain

<400>  18

Glu Asp Asp Ile Glu Ala Asp His Val Gly Phe Tyr Gly Ile Ser Val 
1               5                   10                  15      


Tyr Gln Ser Pro Gly Asp Ile Gly Gln Tyr Thr Phe Glu Phe Asp Gly 
            20                  25                  30          


Asp Glu Trp Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp Arg 
        35                  40                  45              


Leu Pro Glu Phe Gly Gln Leu Thr Ser Phe Asp Pro 
    50                  55                  60  


<210>  19
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse IA1 alpha1 domain

<400>  19

Glu Asp Asp Ile Glu Ala Asp His Val Gly Ser Tyr Gly Ile Val Val 
1               5                   10                  15      


Tyr Gln Ser Pro Gly Asp Ile Gly Gln Tyr Thr His Glu Phe Asp Gly 
            20                  25                  30          


Asp Glu Trp Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp Met 
        35                  40                  45              


Leu Pro Glu Phe Gly Gln Leu Thr Ser Phe Asp Pro 
    50                  55                  60  


<210>  20
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial DRalpha1-hMOG-35-55 sequence

<400>  20

Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
        35                  40                  45              


Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
    50                  55                  


<210>  21
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial DRhQ sequence

<400>  21

Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
        35                  40                  45              


Tyr Gln Asn Pro Asp Gln Ser Gly Glu Phe Met 
    50                  55                  


<210>  22
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial DRalpha1-mMOG-35-55 sequence

<400>  22

Met Glu Val Gly Trp Tyr Arg Pro Ser Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
        35                  40                  45              


Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
    50                  55                  


<210>  23
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial DRmQ sequence

<400>  23

Met Glu Val Gly Trp Tyr Arg Pro Ser Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
        35                  40                  45              


Tyr Gln Asn Pro Asp Gln Ser Gly Glu Phe Met 
    50                  55                  


<210>  24
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified DRalpha1

<400>  24

Met Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Gln 
1               5                   10                  15      


Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu 
            20                  25                  30          


Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu 
        35                  40                  45              


Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn 
    50                  55                  60                  


Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn 
65                  70                  75                  80  


Tyr Thr Pro Ile Thr Asn 
                85      


<210>  25
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide P1

<400>  25

Met Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Gln 
1               5                   10                  15      


Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly 
            20                  25                  30  


<210>  26
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide P2

<400>  26

Gln Ala Glu Phe Tyr Gln Asn Pro Asp Gln Ser Gly Glu Phe Met Phe 
1               5                   10                  15      


Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys 
            20                  25                  30  


<210>  27
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide P3

<400>  27

Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val 
1               5                   10                  15      


Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
            20                  25                  30  


<210>  28
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide P4

<400>  28

Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg 
1               5                   10                  15      


Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly 
            20                  25                  30  


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide P5

<400>  29

Lys Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe 
1               5                   10                  15      


Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala 
            20                  25                  30  


<210>  30
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide P6

<400>  30

Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
1               5                   10                  15      


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn 
            20                  25                  30  


<210>  31
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide P7

<400>  31

Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg 
1               5                   10                  15      


Ser Asn Tyr Thr Pro Ile Thr Asn 
            20                  


<210>  32
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human MOG-35-55

<400>  32

Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  33
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse MOG-35-55

<400>  33

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRBP 1177-1191

<400>  34

Ala Asp Gly Ser Ser Trp Glu Gly Val Gly Val Val Pro Asp Val 
1               5                   10                  15  


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Arrestin 291-310

<400>  35

Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys His Glu 
1               5                   10                  15      


Asp Thr Asn Leu 
            20  


<210>  36
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosducin 65-96

<400>  36

Lys Glu Arg Met Ser Arg Lys Met Ser Ile Gln Glu Tyr Glu Leu Ile 
1               5                   10                  15      


His Gln Asp Lys Glu Asp Glu Gly Cys Leu Arg Lys Tyr Arg Arg Gln 
            20                  25                  30          


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recoverin 48-52

<400>  37

Gln Phe Gln Ser Ile 
1               5   


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recoverin 64-70

<400>  38

Lys Ala Tyr Ala Gln His Val 
1               5           


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recoverin 62-81

<400>  39

Pro Lys Ala Tyr Ala Gln His Val Phe Arg Ser Phe Asp Ala Asn Ser 
1               5                   10                  15      


Asp Gly Thr Leu 
            20  


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recoverin 149-162

<400>  40

Glu Lys Arg Ala Glu Lys Ile Trp Ala Ser Phe Gly Lys Lys 
1               5                   10                  


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagen II 261-274

<400>  41

Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly 
1               5                   10                  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagen II 259-273

<400>  42

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro 
1               5                   10                  15  


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagen II 257-270

<400>  43

Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified collagen II257-270

<400>  44

Ala Pro Gly Ile Ala Gly Phe Lys Ala Glu Gln Ala Ala Lys 
1               5                   10                  


<210>  45
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fibrinogen-alpha  40-59

<400>  45

Val Glu Arg His Gln Ser Ala Cys Lys Asp Ser Asp Trp Pro Phe Cys 
1               5                   10                  15      


Ser Asp Glu Asp 
            20  


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fibrinogen-alpha 616-625

<400>  46

Thr His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly 
1               5                   10                  15      


Ile His Thr Ser 
            20  


<210>  47
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fibrinogen-alpha 79-91

<400>  47

Gln Asp Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser 
1               5                   10              


<210>  48
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fibrinogen-alpha 121-140

<400>  48

Asn Asn Arg Asp Asn Thr Tyr Asn Arg Val Ser Glu Asp Leu Arg Ser 
1               5                   10                  15      


Arg Ile Glu Val 
            20  


<210>  49
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vimentin 59-79

<400>  49

Gly Val Tyr Ala Thr Arg Ser Ser Ala Val Arg Leu Arg Ser Ser Val 
1               5                   10                  15      


Pro Gly Val Arg Leu 
            20      


<210>  50
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vinmentin 26-44

<400>  50

Ser Ser Arg Ser Tyr Val Thr Thr Ser Thr Arg Thr Tyr Ser Leu Gly 
1               5                   10                  15      


Ser Ala Leu 
            


<210>  51
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vimentin 256-275

<400>  51

Ile Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp 
1               5                   10                  15      


Val Arg Gln Gln 
            20  


<210>  52
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vimentin 415-433

<400>  52

Leu Pro Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser 
1               5                   10                  15      


Leu Pro Leu 
            


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-enolase 5-21

<400>  53

Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val 
1               5                   10                  15      


Glu 
    


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human cartilege glycoprotein 39 259-271

<400>  54

Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu 
1               5                   10              


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myelin basic protein 85-99

<400>  55

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15  


<210>  56
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myelin basic protein 145-164

<400>  56

Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg 
1               5                   10                  15      


Asp Ser Arg Ser 
            20  


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proteolipid protein 139-151

<400>  57

Cys His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe Val Gly 
1               5                   10                  15      


<210>  58
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proteolipid protein 95-116

<400>  58

Gly Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly 
1               5                   10                  15      


Lys Gly Leu Ser Ala Thr 
            20          


<210>  59
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG 1-25

<400>  59

Gly Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val 
1               5                   10                  15      


Gly Asp Glu Val 
            20  


<210>  60
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG 94-116

<400>  60

Gly Gly Phe Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala 
1               5                   10                  15      


Ala Met Glu Leu Lys Val Glu 
            20              


<210>  61
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG 145-160

<400>  61

Val Phe Leu Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu 
1               5                   10                  15      


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG 194-208

<400>  62

Leu Val Ala Leu Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu 
1               5                   10                  15  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha2-gliadin 61-71

<400>  63

Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro 
1               5                   10  


<210>  64
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-2 gliadin 58-77

<400>  64

Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu 
1               5                   10                  15      


Pro Tyr Pro Gln 
            20  


