                               SEQUENCE LISTING

<110> VOYAGER THERAPEUTICS, INC.
 
<120> ENGINEERED NUCLEIC ACID CONSTRUCTS ENCODING AAV PRODUCTION 
      PROTEINS

<130> 2057.1512PCT

<140> PCT/US2019/XXXXXX
<141> 2019-10-04

<150> 62/891,670
<151> 2019-08-26

<150> 62/741,855
<151> 2018-10-05

<150> 62/741,764
<151> 2018-10-05

<160> 18    

<170> PatentIn version 3.5

<210> 1
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1
taactataac ggtcctaagg tagcga                                            26


<210> 2
<211> 3530
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 2
tcgctacctt aggaccgtta tagttatgac taactaattg aaactaactt acaagttggc       60

tagtttgtta aaatacgcgc tgcgcttgac tcgggaatac aaagaaaaca ttattccaca      120

ctttgatcac ttgactcgat tgcgcgattt aatcgacggc ttgattaaaa gcgaggatgt      180

acaacgtttt aatcgcacta atcgcaatga tttaatttcg gcttgcttgc aaatcaacgt      240

tcggacgtac ttgcccaacg ccacgataga tttgcgcaaa caacccaact gtatatattt      300

tcgaatttgc caatattgcc acttggaggc cgacgtgcct tcgcccgacg atcattcggt      360

gtacagatac ttgtgcgtcg cgtgcggcac gccgctggtc atcgaccacc cgctcgacgt      420

gttcggccac acggaggaag gcgtcaacga actgctcgag gtgcagcgag tcaacgcggg      480

cggggagttg taggcgtcat aactatttat taaataagat aatttaaaaa atcgccgtta      540

atatggctgc cgatggttat cttccagatt ggctcgagga caaccttagt gaaggaattc      600

gcgagtggtg ggctttgaaa cctggagccc ctcaacccaa ggcaaatcaa caacatcaag      660

acaacgctcg aggtcttgtg cttccgggtt acaaatacct tggacccggc aacggactcg      720

acaaggggga gccggtcaac gcagcagacg cggcggccct cgagcacgac aaggcctacg      780

accagcagct caaggccgga gacaacccgt acctcaagta caaccacgcc gacgccgagt      840

tccaggagcg gctcaaagaa gatacgtctt ttgggggcaa cctcgggcga gcagtcttcc      900

aggccaaaaa gaggcttctt gaacctcttg gtctggttga ggaagcggct aagacggctc      960

ctggaaagaa gaggcctgta gagcagtctc ctcaggaacc ggactcctcc gcgggtattg     1020

gcaaatcggg tgcacagccc gctaaaaaga gactcaattt cggtcagact ggcgacacag     1080

agtcagtccc agaccctcaa ccaatcggag aacctcccgc agccccctca ggtgtgggat     1140

ctcttacaat ggcttcaggt ggtggcgcac cagtggcaga caataacgaa ggtgccgatg     1200

gagtgggtag ttcctcggga aattggcatt gcgattccca atggctgggg gacagagtca     1260

tcaccaccag cacccgaacc tgggccctgc ccacctacaa caatcacctc tacaagcaaa     1320

tctccaacag cacatctgga ggatcttcaa atgacaacgc ctacttcggc tacagcaccc     1380

cctgggggta ttttgacttc aacagattcc actgccactt ctcaccacgt gactggcagc     1440

gactcatcaa caacaactgg ggattccggc ctaagcgact caacttcaag ctcttcaaca     1500

ttcaggtcaa agaggttacg gacaacaatg gagtcaagac catcgccaat aaccttacca     1560

gcacggtcca ggtcttcacg gactcagact atcagctccc gtacgtgctc gggtcggctc     1620

acgagggctg cctcccgccg ttcccagcgg acgttttcat gattcctcag tacgggtatc     1680

tgacgcttaa tgatggaagc caggccgtgg gtcgttcgtc cttttactgc ctggaatatt     1740

tcccgtcgca aatgctaaga acgggtaaca acttccagtt cagctacgag tttgagaacg     1800

tacctttcca tagcagctac gctcacagcc aaagcctgga ccgactaatg aatccactca     1860

tcgaccaata cttgtactat ctctcaagga ctattaacgg ttctggacag aatcaacaaa     1920

cgctaaaatt cagtgtggcc ggacccagca acatggctgt ccagggaaga aactacatac     1980

ctggacccag ctaccgacaa caacgtgtct caaccactgt gactcaaaac aacaacagcg     2040

aatttgcttg gcctggagct tcttcttggg ctctcaatgg acgtaatagc ttgatgaatc     2100

ctggacctgc tatggccagc cacaaagaag gagaggaccg tttctttcct ttgtctggat     2160

ctttaatttt tggcaaacaa ggaactggaa gagacaacgt ggatgcggac aaagtcatga     2220

taaccaacga agaagaaatt aaaactacta acccggtagc aacggagtcc tatggacaag     2280

tggccacaaa ccaccagagt gatgggactt tggcggtgcc ttttaaggca caggcgcaga     2340

ccggctgggt tcaaaaccaa ggaatacttc cgggtatggt ttggcaggac agagatgtgt     2400

acctgcaagg acccatttgg gccaaaattc ctcacacgga cggcaacttt cacccttctc     2460

cgctgatggg agggtttgga atgaagcacc cgcctcctca gatcctcatc aaaaacacac     2520

ctgtacctgc ggatcctcca acggccttca acaaggacaa gctgaactct ttcatcaccc     2580

agtattctac tggccaagtc agcgtggaga tcgagtggga gctgcagaag gaaaacagca     2640

agcgctggaa cccggagatc cagtacactt ccaactatta caagtctaat aatgttgaat     2700

ttgctgttaa tactgaaggt gtatatagtg aaccccgccc cattggcacc agatacctga     2760

ctcgtaatct gtaagtttag tttgcgttaa aaaacaatag ttgttgcaaa atcgacacac     2820

gtgtatcaaa ttggctcgcg ttaaaattgg agaatttaaa tttggagaag atacgttcaa     2880

cctgcggtac gtgctagagc gcgaccaaca ggtccggttc gtggccaagg acgtcgctaa     2940

cagtttaaaa tatacagttt gtgataaagc tatacgtgtt catgtagaca ataaatacaa     3000

atcgttattt gagcagacca tccaaaatgg gggccctacc tctaacagcg tcgtgaaaag     3060

gggcgacccg ctgtatttgc agccgcatac agtgctcatt actaaatccg gcgtgattca     3120

gctgattttg aagtccaaat tgccttacgc catagaatta caagattggc ttttagaaga     3180

agtaattcct caagtgctct gcaccggcaa gtacgatccc gcgatcaaac aacgggagga     3240

ggagagcaaa cagttggtga ctaagctgat tgcgacattc accgagcaca caaacgcgct     3300

gcaagcggtg gtggcgcaaa aaaccgagga acttgttaaa aaacaagagt ttattgaacg     3360

catcgttgcc atcaaggaca agcagatcga ggccaaagat ttgcaggtca cgcgcgtctt     3420

gactgatcta aaccgcttgt acaccggctt ccaggaaacc atgcaaaaga aagacgaaat     3480

aatgcagaaa aaattagtta gtcatcgcta ccttaggacc gttatagtta                3530


<210> 3
<211> 1807
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 3
ctattaatat tccggagtat acggaccttt aattcaaccc aacacaatat attatagtta       60

aataagaatt attatcaaat catttgtata ttaattaaaa tactatactg taaattacat      120

tttatttaca atcactcgac gaagacttga tcaccctcag gtgtgggatc tcttacaatg      180

gcttcaggtg gtggcgcacc agtggcagac aataacgaag gtgccgatgg agtgggtagt      240

tcctcgggaa attggcattg cgattcccaa tggctggggg acagagtcat caccaccagc      300

acccgaacct gggccctgcc cacctacaac aatcacctct acaagcaaat ctccaacagc      360

acatctggag gatcttcaaa tgacaacgcc tacttcggct acagcacccc ctgggggtat      420

tttgacttca acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac      480

aacaactggg gattccggcc taagcgactc aacttcaagc tcttcaacat tcaggtcaaa      540

gaggttacgg acaacaatgg agtcaagacc atcgccaata accttaccag cacggtccag      600

gtcttcacgg actcagacta tcagctcccg tacgtgctcg ggtcggctca cgagggctgc      660

ctcccgccgt tcccagcgga cgttttcatg attcctcagt acgggtatct gacgcttaat      720

gatggaagcc aggccgtggg tcgttcgtcc ttttactgcc tggaatattt cccgtcgcaa      780

atgctaagaa cgggtaacaa cttccagttc agctacgagt ttgagaacgt acctttccat      840

agcagctacg ctcacagcca aagcctggac cgactaatga atccactcat cgaccaatac      900

ttgtactatc tctcaaggac tattaacggt tctggacaga atcaacaaac gctaaaattc      960

agtgtggccg gacccagcaa catggctgtc cagggaagaa actacatacc tggacccagc     1020

taccgacaac aacgtgtctc aaccactgtg actcaaaaca acaacagcga atttgcttgg     1080

cctggagctt cttcttgggc tctcaatgga cgtaatagct tgatgaatcc tggacctgct     1140

atggccagcc acaaagaagg agaggaccgt ttctttcctt tgtctggatc tttaattttt     1200

ggcaaacaag gaactggaag agacaacgtg gatgcggaca aagtcatgat aaccaacgaa     1260

gaagaaatta aaactactaa cccggtagca acggagtcct atggacaagt ggccacaaac     1320

caccagagtg atgggacttt ggcggtgcct tttaaggcac aggcgcagac cggctgggtt     1380

caaaaccaag gaatacttcc gggtatggtt tggcaggaca gagatgtgta cctgcaagga     1440

cccatttggg ccaaaattcc tcacacggac ggcaactttc acccttctcc gctgatggga     1500

gggtttggaa tgaagcaccc gcctcctcag atcctcatca aaaacacacc tgtacctgcg     1560

gatcctccaa cggccttcaa caaggacaag ctgaactctt tcatcaccca gtattctact     1620

ggccaagtca gcgtggagat cgagtgggag ctgcagaagg aaaacagcaa gcgctggaac     1680

ccggagatcc agtacacttc caactattac aagtctaata atgttgaatt tgctgttaat     1740

actgaaggtg tatatagtga accccgcccc attggcacca gatacctgac tcgtaatctg     1800

taagcta                                                               1807


<210> 4
<211> 1807
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
ctattaatat tccggagtat acggaccttt aattcaaccc aacacaatat attatagtta       60

aataagaatt attatcaaat catttgtata ttaattaaaa tactatactg taaattacat      120

tttatttaca atcactcgac gaagacttga tcaccctcag gtgtgggatc tcttacaatg      180

gcttcaggtg gtggcgcacc agtggcagac aataacgaag gtgccgatgg agtgggtagt      240

tcctcgggaa attggcattg cgattcccaa tggctggggg acagagtcat caccaccagc      300

acccgaacct gggccctgcc cacctacaac aatcacctct acaagcaaat ctccaacagc      360

acatctggag gatcttcaaa tgacaacgcc tacttcggct acagcacccc ctgggggtat      420

tttgacttca acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac      480

aacaactggg gattccggcc taagcgactc aacttcaagc tcttcaacat tcaggtcaaa      540

gaggttacgg acaacaatgg agtcaagacc atcgccaata accttaccag cacggtccag      600

gtcttcacgg actcagacta tcagctcccg tacgtgctcg ggtcggctca cgagggctgc      660

ctcccgccgt tcccagcgga cgttttcatg attcctcagt acgggtatct gacgcttaat      720

gatggaagcc aggccgtggg tcgttcgtcc ttttactgcc tggaatattt cccgtcgcaa      780

atgctaagaa cgggtaacaa cttccagttc agctacgagt ttgagaacgt acctttccat      840

agcagctacg ctcacagcca aagcctggac cgactaatga atccactcat cgaccaatac      900

ttgtactatc tctctaagac tattaacggt tctggacaga atcaacaaac gctaaaattc      960

agtgtggccg gacccagcaa catggctgtc cagggaagaa actacatacc tggacccagc     1020

taccgacaac aacgtgtctc aaccactgtg actcaaaaca acaacagcga atttgcttgg     1080

cctggagctt cttcttgggc tctcaatgga cgtaatagct tgatgaatcc tggacctgct     1140

atggccagcc acaaagaagg agaggaccgt ttctttcctt tgtctggatc tttaattttt     1200

ggcaaacaag gtaccggcag agacaacgtg gatgcggaca aagtcatgat aaccaacgaa     1260

gaagaaatta aaactactaa cccggtagca acggagtcct atggacaagt ggccacaaac     1320

caccagagtg acggcacttt ggcggtgcct tttaaggcac aggcgcagac cggttgggtt     1380

caaaaccaag gaatacttcc gggtatggtt tggcaggaca gagatgtgta cctgcaagga     1440

cccatttggg ccaaaattcc tcacacggac ggcaactttc acccttctcc gctgatggga     1500

gggtttggaa tgaagcaccc gcctcctcag atcctcatca aaaacacacc tgtacctgcg     1560

gatcctccaa cggccttcaa caaggacaag ctgaactctt tcatcaccca gtattctact     1620

ggccaagtca gcgtggagat cgagtgggag ctgcagaagg aaaacagcaa gcgctggaac     1680

ccggagatcc agtacacttc caactattac aagtctaata atgttgaatt tgctgttaat     1740

actgaaggtg tatatagtga accccgcccc attggcacca gatacctgac tcgtaatctg     1800

taagcta                                                               1807


<210> 5
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 5
agtctgcatt ttacacgcgt tgttaatc                                          28


<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 6
tatacgatcc agagcgctac gctc                                              24


<210> 7
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 7
ccaagtcagc gtggagatcg agt                                               23


<210> 8
<211> 3094
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
cctaggggcc ggcctgacta actaatgaaa ctaacttaca agttggctag tttgttaaaa       60

tacgcgctgc gcttgactcg ggaatacaaa gaaaacatta ttccacactt tgatcacttg      120

actcgattgc gcgatttaat cgacggcttg attaaaagcg aggatgtaca acgttttaat      180

cgcactaatc gcaatgattt aatttcggct tgcttgcaaa tcaacgttcg gacgtacttg      240

cccaacgcca cgatagattt gcgcaaacaa cccaactgta tatattttcg aatttgccaa      300

tattgccact tggaggccga cgtgccttcg cccgacgatc attcggtgta cagatacttg      360

tgcgtcgcgt gcggcacgcc gctggtcatc gaccacccgc tcgacgtgtt cggccacacg      420

gaggaaggcg tcaacgaact gctcgaggtg cagcgagtca acgcgggcgg ggagttgtag      480

gcgtcataac tatttattaa ataagataat ttaaaaaatc gccgttaata tggctcctgg      540

aaagaagagg cctgtagagc agtctcctca ggaaccggac tcctccgcgg gtattggcaa      600

atcgggtgca cagcccgcta aaaagagact caatttcggt cagactggcg acacagagtc      660

agtcccagac cctcaaccaa tcggagaacc tcccgcagcc ccctcaggtg tgggatctct      720

tacaatggct tcaggtggtg gcgcaccagt ggcagacaat aacgaaggtg ccgatggagt      780

gggtagttcc tcgggaaatt ggcattgcga ttcccaatgg ctgggggaca gagtcatcac      840

caccagcacc cgaacctggg ccctgcccac ctacaacaat cacctctaca agcaaatctc      900

caacagcaca tctggaggat cttcaaatga caacgcctac ttcggctaca gcaccccctg      960

ggggtatttt gacttcaaca gattccactg ccacttctca ccacgtgact ggcagcgact     1020

catcaacaac aactggggat tccggcctaa gcgactcaac ttcaagctct tcaacattca     1080

ggtcaaagag gttacggaca acaatggagt caagaccatc gccaataacc ttaccagcac     1140

ggtccaggtc ttcacggact cagactatca gctcccgtac gtgctcgggt cggctcacga     1200

gggctgcctc ccgccgttcc cagcggacgt tttcatgatt cctcagtacg ggtatctgac     1260

gcttaatgat ggaagccagg ccgtgggtcg ttcgtccttt tactgcctgg aatatttccc     1320

gtcgcaaatg ctaagaacgg gtaacaactt ccagttcagc tacgagtttg agaacgtacc     1380

tttccatagc agctacgctc acagccaaag cctggaccga ctaatgaatc cactcatcga     1440

ccaatacttg tactatctct caaggactat taacggttct ggacagaatc aacaaacgct     1500

aaaattcagt gtggccggac ccagcaacat ggctgtccag ggaagaaact acatacctgg     1560

acccagctac cgacaacaac gtgtctcaac cactgtgact caaaacaaca acagcgaatt     1620

tgcttggcct ggagcttctt cttgggctct caatggacgt aatagcttga tgaatcctgg     1680

acctgctatg gccagccaca aagaaggaga ggaccgtttc tttcctttgt ctggatcttt     1740

aatttttggc aaacaaggaa ctggaagaga caacgtggat gcggacaaag tcatgataac     1800

caacgaagaa gaaattaaaa ctactaaccc ggtagcaacg gagtcctatg gacaagtggc     1860

cacaaaccac cagagtgatg ggactttggc ggtgcctttt aaggcacagg cgcagaccgg     1920

ctgggttcaa aaccaaggaa tacttccggg tatggtttgg caggacagag atgtgtacct     1980

gcaaggaccc atttgggcca aaattcctca cacggacggc aactttcacc cttctccgct     2040

gatgggaggg tttggaatga agcacccgcc tcctcagatc ctcatcaaaa acacacctgt     2100

acctgcggat cctccaacgg ccttcaacaa ggacaagctg aactctttca tcacccagta     2160

ttctactggc caagtcagcg tggagatcga gtgggagctg cagaaggaaa acagcaagcg     2220

ctggaacccg gagatccagt acacttccaa ctattacaag tctaataatg ttgaatttgc     2280

tgttaatact gaaggtgtat atagtgaacc ccgccccatt ggcaccagat acctgactcg     2340

taatctgtaa gtttagtttg cgttaaaaaa caatagttgt tgcaaaatcg acacacgtgt     2400

atcaaattgg ctcgcgttaa aattggagaa tttaaatttg gagaagatac gttcaacctg     2460

cggtacgtgc tagagcgcga ccaacaggtc cggttcgtgg ccaaggacgt cgctaacagt     2520

ttaaaatata cagtttgtga taaagctata cgtgttcatg tagacaataa atacaaatcg     2580

ttatttgagc agaccatcca aaatgggggc cctacctcta acagcgtcgt gaaaaggggc     2640

gacccgctgt atttgcagcc gcatacagtg ctcattacta aatccggcgt gattcagctg     2700

attttgaagt ccaaattgcc ttacgccata gaattacaag attggctttt agaagaagta     2760

attcctcaag tgctctgcac cggcaagtac gatcccgcga tcaaacaacg ggaggaggag     2820

agcaaacagt tggtgactaa gctgattgcg acattcaccg agcacacaaa cgcgctgcaa     2880

gcggtggtgg cgcaaaaaac cgaggaactt gttaaaaaac aagagtttat tgaacgcatc     2940

gttgccatca aggacaagca gatcgaggcc aaagatttgc aggtcacgcg cgtcttgact     3000

gatctaaacc gcttgtacac cggcttccag gaaaccatgc aaaagaaaga cgaaataatg     3060

cagaaaaaat tagttagtca ggccggcccc tagg                                 3094


<210> 9
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 9
agagaatagc cgtcgccaca atg                                               23


<210> 10
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
gccattggga atcgcaatgc ca                                                22


<210> 11
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 11
attggcacca gatacctgac tcg                                               23


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
agtcccatgt cgtcggcaag                                                   20


<210> 13
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (1)..(50)
<223> /note="This sequence may encompass 1-10 'Gly Gly Gly Gly Ser'
      repeating units"

<400> 13
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210> 14
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 15
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Gly Gly Gly Gly Ser 
1               5   


<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Ile"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> SITE
<222> (1)..(8)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 17
Asp Val Glu Xaa Asn Pro Gly Pro 
1               5               


<210> 18
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cleavage site"

<400> 18
Asn Pro Gly Pro 
1               


