                         SEQUENCE LISTING

<110>  Rutgers, The State University of New Jersey
       Siracusa, Mark
 
<120>  METHODS OF REDUCDING TYPE 2 CYTOKINE-MEDIATED INFLAMMATION USING 
       NEUROMEDIN PEPTIDES

<130>   7213-101257-02

<150>  US 62/741,188
<151>  2018-10-04

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuromedin B with C-terminal amidation


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  1

Gly Asn Leu Trp Ala Thr Gly His Phe Met 
1               5                   10  


<210>  2
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  2
ggcaacctct gggccaccgg tcacttcatg                                        30


<210>  3
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  3

Ala Asn Leu Trp Ala Thr Gly His Phe Met 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Amidation

<400>  4

Gly Ala Leu Trp Ala Thr Gly His Phe Met 
1               5                   10  


<210>  5
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  5

Gly Asn Ala Trp Ala Thr Gly His Phe Met 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  6

Gly Asn Leu Ala Ala Thr Gly His Phe Met 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  7

Gly Asn Leu Trp Ala Ala Gly His Phe Met 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  8

Gly Asn Leu Trp Ala Thr Ala His Phe Met 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  9

Gly Asn Leu Trp Ala Thr Gly Ala Phe Met 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  10

Gly Asn Leu Trp Ala Thr Gly His Ala Met 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  11

Gly Asn Leu Trp Ala Thr Gly His Phe Ala 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  Acetylation
<222>  (1)..(1)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  12

Gly Leu Leu Trp Ala Thr Gly His Phe Met 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Methanesulfonyl

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  13

Gly Asn Leu Trp Ala Thr Gly His Phe Met 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  N-methylation

<400>  14

Gly Asn Leu Trp Ala Thr Gly His Phe Met 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Free acid

<220>
<221>  MOD_RES
<222>  (10)..(10)

<400>  15

Gly Asn Leu Trp Ala Thr Gly His Phe Met 
1               5                   10  


<210>  16
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  16

Asn Leu Trp Ala Thr Gly His Phe Met 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  17

Gly Leu Trp Ala Thr Gly His Phe Met 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  18

Gly Asn Trp Ala Thr Gly His Phe Met 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  19

Gly Asn Leu Ala Thr Gly His Phe Met 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  20

Gly Asn Leu Trp Thr Gly His Phe Met 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  21

Gly Asn Leu Trp Ala Gly His Phe Met 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  22

Gly Asn Leu Trp Ala Thr His Phe Met 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  23

Gly Asn Leu Trp Ala Thr Gly Phe Met 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  24

Gly Asn Leu Trp Ala Thr Gly His Met 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  25

Gly Asn Leu Trp Ala Thr Gly His Phe 
1               5                   


<210>  26
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  26

Gly Asn Leu Trp Ala Thr Gly His 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  27

Asn Leu Trp Ala Thr Gly His Phe 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  28

Leu Trp Ala Thr Gly His Phe Met 
1               5               


<210>  29
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  29

Gly Asn Leu Trp Ala Thr Gly 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  30

Asn Leu Trp Ala Thr Gly His 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  31

Leu Trp Ala Thr Gly His Phe 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  32

Trp Ala Thr Gly His Phe Met 
1               5           


<210>  33
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  AMIDATION

<400>  33

Gly Asn Leu Trp Ala Thr 
1               5       


<210>  34
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  AMIDATION

<400>  34

Asn Leu Trp Ala Thr Gly 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  AMIDATION

<400>  35

Leu Trp Ala Thr Gly His 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  AMIDATION

<400>  36

Trp Ala Thr Gly His Phe 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant neuromedin B peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  AMIDATION

<400>  37

Ala Thr Gly His Phe Met 
1               5       


<210>  38
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Asn His Trp Ala Val Gly His Leu Met 
1               5                   10  


<210>  39
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  39

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  40
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  40

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  41
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  41

Pro Ile Arg Arg Arg Lys Lys Leu Arg Arg Leu Lys 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  42

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  43
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  43

Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  


<210>  44
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  44

Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      


Thr Ala Arg 
            


<210>  45
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  45

Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  46

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  47
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  47

Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  48
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  48

Arg Gln Ile Lys Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15  


<210>  49
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  49

Lys Leu Ala Leu Lys Leu Ala Leu Lys Leu Ala Leu Ala Leu Lys Leu 
1               5                   10                  15      


Ala 
    


<210>  50
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  50

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  51
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  51

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  52
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Acetylation

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Cysteamide

<400>  52

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  53
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  acetylation

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Cysteamide

<400>  53

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val 
            20                  25          


<210>  54
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Acetylation

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Cysteamide

<400>  54

Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  55
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  55

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  56
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Acetylation

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Cysteamide

<400>  56

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  57
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  57

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  58
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cell penetrating peptide

<400>  58

Pro Phe Val Tyr Leu Ile 
1               5       


