                         SEQUENCE LISTING

<110>  UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF 
       HIGHER EDUCATION
 
<120>  COVALENT ADAPTOR SYNNOTCH AND CHIMERIC ANTIGEN RECEPTORS (CARS) 
       FOR PROGRAMMABLE ANTIGENTARGETING

<130>  10504-033WO1

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  2067
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
atggagacag acacactcct gctatgggtg ctgctgctct gggttccagg ttccacaggt       60

atggacaaag attgcgagat gaagagaacc accctggata gccctctcgg caagctcgaa      120

ctttctggtt gtgaacaggg tttgcacagg atcatcttcc tgggaaaggg aacctcagcc      180

gcagatgcgg ttgaagtgcc agctccggct gcagtgcttg gtggacccga gcctcttatg      240

caagcaacgg catggcttaa tgcttatttt caccagcctg aggccattga agagtttcca      300

gttcctgcat tgcatcaccc cgtttttcag caggaatcct tcactagaca agtgctttgg      360

aagctcttga aagtggttaa atttggggaa gtcatctcat acagccacct tgctgccctt      420

gcaggcaatc ctgcggccac ggctgcagtg aaaactgcac ttagcggaaa tccagtcccc      480

atcttgatac cgtgtcacag ggtagtacag ggcgacctgg acgtcggcgg ttacgagggc      540

ggtttggccg ttaaggaatg gttgctggcg catgagggtc accggctggg aaaaccaggt      600

cttggtggag gaagtggagg atctaccact actccggcac cgcgcccccc aactcctgca      660

ccgacgatag cttcacaacc gctttcattg cggcccgaag catgtcggcc agccgccgga      720

ggcgctgtgc atacaagagg gctggatttt gcatgtgata tatatatttg ggcgcccctt      780

gctggcactt gcggcgttct tcttcttagc ctcgttatta cgctctactg taagcgaggt      840

aggaaaaaat tgctgtatat ctttaaacag ccttttatga gacccgtgca aacgactcaa      900

gaggaagacg ggtgtagctg tagatttcct gaagaggaag agggggggtg cgaactgcgg      960

gtgaagttca gcagaagcgc cgacgcccct gcctaccagc agggccagaa tcagctgtac     1020

aacgagctga acctgggcag aagggaagag tacgacgtcc tggataagcg gagaggccgg     1080

gaccctgaga tgggcggcaa gcctcggcgg aagaaccccc aggaaggcct gtataacgaa     1140

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcggagg     1200

cggggcaagg gccacgacgg cctgtatcag ggcctgtcca ccgccaccaa ggatacctac     1260

gacgccctgc acatgcaggc cctgccccca aggctcgagg gcggcggaga gggcagagga     1320

agtcttctaa catgcggtga cgtggaggag aatcccggcc ctcgcatgag cgagctgatt     1380

aaggagaaca tgcacatgaa gctgtacatg gagggcaccg tggacaacca tcacttcaag     1440

tgcacatccg agggcgaagg caagccctac gagggcaccc agaccatgag aatcaaggtg     1500

gtcgagggcg gccctctccc cttcgccttc gacatcctgg ctactagctt cctctacggc     1560

agcaagacct tcatcaacca cacccagggc atccccgact tcttcaagca gtccttccct     1620

gagggcttca catgggagag agtcaccaca tacgaagacg ggggcgtgct gaccgctacc     1680

caggacacca gcctccagga cggctgcctc atctacaacg tcaagatcag aggggtgaac     1740

ttcacatcca acggccctgt gatgcagaag aaaacactcg gctgggaggc cttcaccgag     1800

acgctgtacc ccgctgacgg cggcctggaa ggcagaaacg acatggccct gaagctcgtg     1860

ggcgggagcc atctgatcgc aaacatcaag accacatata gatccaagaa acccgctaag     1920

aacctcaaga tgcctggcgt ctactatgtg gactacagac tggaaagaat caaggaggcc     1980

aacaacgaaa catacgtcga gcagcacgag gtggcagtgg ccagatactg cgacctccct     2040

agcaaactgg ggcacaagct taattaa                                         2067


<210>  2
<211>  2271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
atggcgctcc ctgtcaccgc actgcttctt ccgctggcac tgctgctgca cgctgcacgg       60

cctgagcaaa aacttatctc tgaagaggac ctcatggaca aagattgcga gatgaagaga      120

accaccctgg atagccctct cggcaagctc gaactttctg gttgtgaaca gggtttgcac      180

aggatcatct tcctgggaaa gggaacctca gccgcagatg cggttgaagt gccagctccg      240

gctgcagtgc ttggtggacc cgagcctctt atgcaagcaa cggcatggct taatgcttat      300

tttcaccagc ctgaggccat tgaagagttt ccagttcctg cattgcatca ccccgttttt      360

cagcaggaat ccttcactag acaagtgctt tggaagctct tgaaagtggt taaatttggg      420

gaagtcatct catacagcca ccttgctgcc cttgcaggca atcctgcggc cacggctgca      480

gtgaaaactg cacttagcgg aaatccagtc cccatcttga taccgtgtca cagggtagta      540

cagggcgacc tggacgtcgg cggttacgag ggcggtttgg ccgttaagga atggttgctg      600

gcgcatgagg gtcaccggct gggaaaacca ggtcttggtg gaggaagtgg aggatctatc      660

ctggactaca gcttcacagg tggcgctggg cgcgacattc ccccaccgca gattgaggag      720

gcctgtgagc tgcctgagtg ccaggtggat gcaggcaata aggtctgcaa cctgcagtgt      780

aataatcacg catgtggctg ggatggtggc gactgctccc tcaacttcaa tgacccctgg      840

aagaactgca cgcagtctct acagtgctgg aagtatttta gcgacggcca ctgtgacagc      900

cagtgcaact cggccggctg cctctttgat ggcttcgact gccagctcac cgagggacag      960

tgcaaccccc tgtatgacca gtactgcaag gaccacttca gtgatggcca ctgcgaccag     1020

ggctgtaaca gtgccgaatg tgagtgggat ggcctagact gtgctgagca tgtacccgag     1080

cggctggcag ccggcaccct ggtgctggtg gtgctgcttc cacccgacca gctacggaac     1140

aactccttcc actttctgcg ggagctcagc cacgtgctgc acaccaacgt ggtcttcaag     1200

cgtgatgcgc aaggccagca gatgatcttc ccgtactatg gccacgagga agagctgcgc     1260

aagcacccaa tcaagcgctc tacagtgggt tgggccacct cttcactgct tcctggtacc     1320

agtggtgggc gccagcgcag ggagctggac cccatggaca tccgtggctc cattgtctac     1380

ctggagatcg acaaccggca atgtgtgcag tcatcctcgc agtgcttcca gagtgccacc     1440

gatgtggctg ccttcctagg tgctcttgcg tcacttggca gcctcaatat tccttacaag     1500

attgaggccg tgaagagtga gccggtggag cctccgctgc cctcgcagct gcacctcatg     1560

tacgtggcag cggccgcctt cgtgctcctg ttctttgtgg gctgtggggt gctgctgtcc     1620

cgcaagcgcc ggcggatgaa gctgctgagc agcatcgagc aggcctgtga catctgccgg     1680

ctgaagaaac tgaagtgcag caaagaaaag cccaagtgcg ccaagtgcct gaagaacaac     1740

tgggagtgcc ggtacagccc caagaccaag agaagccccc tgaccagagc ccacctgacc     1800

gaggtggaaa gccggctgga aagactggaa cagctgtttc tgctgatctt cccacgcgag     1860

gacctggaca tgatcctgaa gatggacagc ctgcaggaca tcaaggccct gctgaccggc     1920

ctgttcgtgc aggacaacgt gaacaaggac gccgtgaccg acagactggc cagcgtggaa     1980

accgacatgc ccctgaccct gcggcagcac agaatcagcg ccaccagcag cagcgaggaa     2040

agcagcaaca agggccagcg gcagctgaca gtgtctgctg ctgcaggcgg aagcggaggc     2100

tctggcggat ctgatgccct ggacgacttc gacctggata tgctgggcag cgacgccctg     2160

gatgattttg atctggacat gctgggatct gacgctctgg acgatttcga tctcgacatg     2220

ttgggatcag atgcactgga tgactttgac ctggacatgc tcggatcatg a              2271


<210>  3
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
atggacaaag attgcgagat gaagagaacc accctggata gccctctcgg caagctcgaa       60

ctttctggtt gtgaacaggg tttgcacagg atcatcttcc tgggaaaggg aacctcagcc      120

gcagatgcgg ttgaagtgcc agctccggct gcagtgcttg gtggacccga gcctcttatg      180

caagcaacgg catggcttaa tgcttatttt caccagcctg aggccattga agagtttcca      240

gttcctgcat tgcatcaccc cgtttttcag caggaatcct tcactagaca agtgctttgg      300

aagctcttga aagtggttaa atttggggaa gtcatctcat acagccacct tgctgccctt      360

gcaggcaatc ctgcggccac ggctgcagtg aaaactgcac ttagcggaaa tccagtcccc      420

atcttgatac cgtgtcacag ggtagtacag ggcgacctgg acgtcggcgg ttacgagggc      480

ggtttggccg ttaaggaatg gttgctggcg catgagggtc accggctggg aaaaccaggt      540

cttggtggag gaagtggagg atct                                             564


<210>  4
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
cgggtgaagt tcagcagaag cgccgacgcc cctgcctacc agcagggcca gaatcagctg       60

tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc      120

cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg      240

aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc      300

tacgacgccc tgcacatgca ggccctgccc ccaagg                                336


<210>  5
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
atcctggact acagcttcac aggtggcgct gggcgcgaca ttcccccacc gcagattgag       60

gaggcctgtg agctgcctga gtgccaggtg gatgcaggca ataaggtctg caacctgcag      120

tgtaataatc acgcatgtgg ctgggatggt ggcgactgct ccctcaactt caatgacccc      180

tggaagaact gcacgcagtc tctacagtgc tggaagtatt ttagcgacgg ccactgtgac      240

agccagtgca actcggccgg ctgcctcttt gatggcttcg actgccagct caccgaggga      300

cagtgcaacc ccctgtatga ccagtactgc aaggaccact tcagtgatgg ccactgcgac      360

cagggctgta acagtgccga atgtgagtgg gatggcctag actgtgctga gcatgtaccc      420

gagcggctgg cagccggcac cctggtgctg gtggtgctgc ttccacccga ccagctacgg      480

aacaactcct tccactttct gcgggagctc agccacgtgc tgcacaccaa cgtggtcttc      540

aagcgtgatg cgcaaggcca gcagatgatc ttcccgtact atggccacga ggaagagctg      600

cgcaagcacc caatcaagcg ctctacagtg ggttgggcca cctcttcact gcttcctggt      660

accagtggtg ggcgccagcg cagggagctg gaccccatgg acatccgtgg ctccattgtc      720

tacctggaga tcgacaaccg gcaatgtgtg cagtcatcct cgcagtgctt ccagagtgcc      780

accgatgtgg ctgccttcct aggtgctctt gcgtcacttg gcagcctcaa tattccttac      840

aagattgagg ccgtgaagag tgagccggtg gagcctccgc tgccctcgca gctgcacctc      900

atgtacgtgg cagcggccgc cttcgtgctc ctgttctttg tgggctgtgg ggtgctgctg      960

tcccgcaagc gccggcgg                                                    978


<210>  6
<211>  2122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
ggagcaaggc aggtggacag tggatcatgg agacagacac actcctgcta tgggtgctgc       60

tgctctgggt tccaggttcc acaggtatgg acaaagattg cgagatgaag agaaccaccc      120

tggatagccc tctcggcaag ctcgaacttt ctggttgtga acagggtttg cacaggatca      180

tcttcctggg aaagggaacc tcagccgcag atgcggttga agtgccagct ccggctgcag      240

tgcttggtgg acccgagcct cttatgcaag caacggcatg gcttaatgct tattttcacc      300

agcctgaggc cattgaagag tttccagttc ctgcattgca tcaccccgtt tttcagcagg      360

aatccttcac tagacaagtg ctttggaagc tcttgaaagt ggttaaattt ggggaagtca      420

tctcatacag ccaccttgct gcccttgcag gcaatcctgc ggccacggct gcagtgaaaa      480

ctgcacttag cggaaatcca gtccccatct tgataccgtg tcacagggta gtacagggcg      540

acctggacgt cggcggttac gagggcggtt tggccgttaa ggaatggttg ctggcgcatg      600

agggtcaccg gctgggaaaa ccaggtcttg gtggaggaag tggaggatct accactactc      660

cggcaccgcg ccccccaact cctgcaccga cgatagcttc acaaccgctt tcattgcggc      720

ccgaagcatg tcggccagcc gccggaggcg ctgtgcatac aagagggctg gattttgcat      780

gtgatatata tatttgggcg ccccttgctg gcacttgcgg cgttcttctt cttagcctcg      840

ttattacgct ctactgtaag cgaggtagga aaaaattgct gtatatcttt aaacagcctt      900

ttatgagacc cgtgcaaacg actcaagagg aagacgggtg tagctgtaga tttcctgaag      960

aggaagaggg ggggtgcgaa ctgcgggtga agttcagcag aagcgccgac gcccctgcct     1020

accagcaggg ccagaatcag ctgtacaacg agctgaacct gggcagaagg gaagagtacg     1080

acgtcctgga taagcggaga ggccgggacc ctgagatggg cggcaagcct cggcggaaga     1140

acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag gcctacagcg     1200

agatcggcat gaagggcgag cggaggcggg gcaagggcca cgacggcctg tatcagggcc     1260

tgtccaccgc caccaaggat acctacgacg ccctgcacat gcaggccctg cccccaaggc     1320

tcgagggcgg cggagagggc agaggaagtc ttctaacatg cggtgacgtg gaggagaatc     1380

ccggccctcg catgagcgag ctgattaagg agaacatgca catgaagctg tacatggagg     1440

gcaccgtgga caaccatcac ttcaagtgca catccgaggg cgaaggcaag ccctacgagg     1500

gcacccagac catgagaatc aaggtggtcg agggcggccc tctccccttc gccttcgaca     1560

tcctggctac tagcttcctc tacggcagca agaccttcat caaccacacc cagggcatcc     1620

ccgacttctt caagcagtcc ttccctgagg gcttcacatg ggagagagtc accacatacg     1680

aagacggggg cgtgctgacc gctacccagg acaccagcct ccaggacggc tgcctcatct     1740

acaacgtcaa gatcagaggg gtgaacttca catccaacgg ccctgtgatg cagaagaaaa     1800

cactcggctg ggaggccttc accgagacgc tgtaccccgc tgacggcggc ctggaaggca     1860

gaaacgacat ggccctgaag ctcgtgggcg ggagccatct gatcgcaaac atcaagacca     1920

catatagatc caagaaaccc gctaagaacc tcaagatgcc tggcgtctac tatgtggact     1980

acagactgga aagaatcaag gaggccaaca acgaaacata cgtcgagcag cacgaggtgg     2040

cagtggccag atactgcgac ctccctagca aactggggca caagcttaat taagatcctt     2100

gacttgcggc cgcaactccc ac                                              2122


<210>  7
<211>  624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
gagcaaaaac ttatctctga agaggacctc atggacaaag attgcgagat gaagagaacc       60

accctggata gccctctcgg caagctcgaa ctttctggtt gtgaacaggg tttgcacagg      120

atcatcttcc tgggaaaggg aacctcagcc gcagatgcgg ttgaagtgcc agctccggct      180

gcagtgcttg gtggacccga gcctcttatg caagcaacgg catggcttaa tgcttatttt      240

caccagcctg aggccattga agagtttcca gttcctgcat tgcatcaccc cgtttttcag      300

caggaatcct tcactagaca agtgctttgg aagctcttga aagtggttaa atttggggaa      360

gtcatctcat acagccacct tgctgccctt gcaggcaatc ctgcggccac ggctgcagtg      420

aaaactgcac ttagcggaaa tccagtcccc atcttgatac cgtgtcacag ggtagtacag      480

ggcgacctgg acgtcggcgg ttacgagggc ggtttggccg ttaaggaatg gttgctggcg      540

catgagggtc accggctggg aaaaccaggt cttggtggag gaagtggagg atctatcctg      600

gactacagct tcacaggtgg cgct                                             624


<210>  8
<211>  624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
gagcaaaaac ttatctctga agaggacctc atggacaaag attgcgagat gaagagaacc       60

accctggata gccctctcgg caagctcgaa ctttctggtt gtgaacaggg tttgcacagg      120

atcatcttcc tgggaaaggg aacctcagcc gcagatgcgg ttgaagtgcc agctccggct      180

gcagtgcttg gtggacccga gcctcttatg caagcaacgg catggcttaa tgcttatttt      240

caccagcctg aggccattga agagtttcca gttcctgcat tgcatcaccc cgtttttcag      300

caggaatcct tcactagaca agtgctttgg aagctcttga aagtggttaa atttggggaa      360

gtcatctcat acagccacct tgctgccctt gcaggcaatc ctgcggccac ggctgcagtg      420

aaaactgcac ttagcggaaa tccagtcccc atcttgatac cgtgtcacag ggtagtacag      480

ggcgacctgg acgtcggcgg ttacgagggc ggtttggccg ttaaggaatg gttgctggcg      540

catgagggtc accggctggg aaaaccaggt cttggtggag gaagtggagg atctatcctg      600

gactacagct tcacaggtgg cgct                                             624


<210>  9
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
ccgatccagc ctctcgacat tcgttggatc atgttccacg taagtttcag atatatcttt       60

ggacttccgc cgctcatatt ggtattgttg ccagtggcat ctagtgactg tgacatagaa      120

ggaaaggatg gtaaacagta tgaaagcgta cttatggtat ccattgacca gcttctcgat      180

agtatgaaag agattggtag taattgcctc aataacgagt tcaatttctt taaacgacac      240

atttgtgatg cgaataaaga gggaatgttt ctgtttcgcg ccgcgaggaa gcttaggcag      300

ttccttaaaa tgaactcaac tggggatttc gacctccatc tgctgaaggt gagtgaaggt      360

actactattc tcctgaattg cacgggacag gtaaaggggc gaaaacctgc ggccttgggt      420

gaggcacaac caaccaaaag cctcgaagaa aacaagtccc tcaaagaaca gaagaagctc      480

aacgatctgt gctttctgaa aagactcttg caggagatca aaacttgttg gaataagatt      540

ttgatgggca ctaaggagca ttaagatcct tgacttgcgg ccgcaactcc c               591


