                         SEQUENCE LISTING

<110>  EMORY UNIVERSITY
       CHILDREN'S HEALTHCARE OF ATLANTA, INC.
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF HEMOPHAGOCYTIC 
       LYMPHOHISTIOCYTOSIS

<130>  043150-1155054 (057WO1)

<150>  US 62/739,593
<151>  2018-10-01

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  3273
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  1
atggcaacac tcctcagtca tccacagcag agacctcctt tcctcagaca ggcaatcaaa       60

atcagacggc ggcgggtgcg ggacctccag gatcccccac cccagatggc cccagaaatc      120

cagccaccca gccaccactt ctcccccgaa cagagggctc tgctgtacga ggacgccctg      180

tacaccgtgc tgcacagact gggccaccca gagcccaacc acgtgaccga agccagcgag      240

ctgctgaggt acctgcagga agctttccac gtggagccag aggaacacca gcagaccctg      300

cagagagtga gagaactgga gaagcccatc ttctgcctga aggctaccgt gaagcaggcc      360

aagggcatcc tgggcaagga cgtgagcggc ttctccgatc cctactgcct gctgggcatc      420

gagcaggggg tgggggtgcc aggcggcagc cccggctcca ggcacagaca gaaggctgtc      480

gtgaggcaca ccatcccaga agaagaaaca cacagaaccc aggtgatcac ccagaccctg      540

aaccccgtgt gggacgaaac cttcatcctg gaattcgagg acatcaccaa tgccagcttc      600

cacctggaca tgtgggacct ggataccgtg gaatccgtga ggcagaagct gggcgagctg      660

accgatctgc acggcctgag gagaatcttc aaggaagcta ggaaggacaa gggccaggac      720

gatttcctgg gcaacgtggt gctgagactg caggacctga ggtgcagaga ggatcagtgg      780

tacccactgg aacccaggac cgaaacctac ccagatagag gccagtgcca cctgcagttc      840

cagctgatcc acaagaggag agctaccagc gcctccagaa gccagcccag ctacaccgtg      900

cacctgcacc tgctgcagca gctggtgtcc cacgaagtga cccagcacga ggctggatcc      960

accagctggg atggctccct gagcccacag gctgctaccg tgctgttcct gcacgctacc     1020

cagaaggacc tgagcgattt ccaccagtcc atggcccagt ggctggctta cagcaggctg     1080

taccagtccc tggagttccc aagctcctgc ctgctgcacc ccatcaccag catcgaatac     1140

cagtggatcc agggcagact gaaggccgag cagcaggaag agctggccgc ttccttcagc     1200

tccctgctga cctacggcct gagcctgatc aggagattca ggtccgtgtt cccactgtcc     1260

gtgagcgatt cccccgctag gctgcagagc ctgctgagag tgctggtgca gatgtgcaag     1320

atgaaggctt tcggcgaact gtgcccaaat accgccccac tgccacagct ggtgaccgaa     1380

gctctgcaga ccggcaccac cgagtggttc cacctgaagc agcagcacca ccagccaatg     1440

gtgcagggca tcccagaggc tgggaaggct ctgctgggcc tggtgcagga cgtgatcggc     1500

gatctgcacc agtgccagag gacctgggac aagatcttcc acaataccct gaagatccac     1560

ctgttcagca tggccttcag ggagctgcag tggctggtgg ctaagagagt gcaggaccac     1620

accaccgtgg tgggcgatgt ggtgagccca gaaatgggcg agtccctgtt ccagctgtac     1680

atcagcctga aggaactgtg ccagctgagg atgagcagct ccgagagaga tggggtgctg     1740

gctctggata acttccacag gtggttccag ccagctatcc ccagctggct gcagaagacc     1800

tacaatgagg ctctggccag ggtgcagaga gccgtgcaga tggatgaact ggtgcccctg     1860

ggcgagctga ccaagcacag cacctccgct gtggacctga gcacctgctt cgctcagatc     1920

tcccacaccg ctaggcagct ggactggcca gatccagaag aggccttcat gatcaccgtg     1980

aagttcgtgg aagacacctg cagactggct ctggtgtact gcagcctgat caaggctagg     2040

gccagagagc tgtcctccgg acagaaggat cagggacagg ctgctaacat gctgtgcgtg     2100

gtggtgaatg acatggagca gctgaggctg gtgatcggaa agctgccagc tcagctggct     2160

tgggaagctc tggagcagag ggtgggggct gtgctggaac agggacagct gcagaacacc     2220

ctgcacgctc agctgcagag cgctctggct ggcctgggac acgagatcag gaccggcgtg     2280

agaaccctgg ctgaacagct ggaagtgggc atcgccaagc acatccagaa gctggtgggc     2340

gtgagggaaa gcgtgctgcc agaggatgcc atcctgcccc tgatgaagtt cctggaagtg     2400

gagctgtgct acatgaacac caatctggtg caggaaaatt tctccagcct gctgaccctg     2460

ctgtggaccc acaccctgac cgtgctggtg gaggctgctg ctagccagag gtccagctcc     2520

ctggcttcca acagactgaa gatcgccctg cagaatctgg aaatctgctt ccacgctgag     2580

ggatgcggcc tgccacccaa ggccctgcac accgctacct tccaggccct gcagagggac     2640

ctggaactgc aggctgccag ctccagggag ctgatcagaa agtacttctg cagcagaatc     2700

cagcagcagg ccgaaaccac ctccgaagag ctgggcgctg tgaccgtgaa ggctagctac     2760

agggcctccg aacagaagct gagagtggag ctgctgagcg ctagctccct gctgccactg     2820

gactccaacg gcagctccga tcccttcgtg cagctgaccc tggaaccaag gcacgaattc     2880

cccgagctgg ctgccagaga aacccagaag cacaagaagg acctgcaccc cctgttcgat     2940

gaaaccttcg agttcctggt gcccgcagaa ccctgcagaa aggctggggc ttgcctgctg     3000

ctgaccgtgc tggactacga taccctgggc gctgacgatc tggaaggcga ggccttcctg     3060

cccctgagag aagtgccagg cctgagcgga tccgaagaac ccggggaggt gccacagacc     3120

agactgccac tgacctaccc agcccccaat ggcgatccca tcctgcagct gctggaaggc     3180

aggaagggcg acagagaggc tcaggtgttc gtcagactca ggagacatag agcaaaacag     3240

gcatcacagc acgccctcag accagccccc tag                                  3273


<210>  2
<211>  1815
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  2
atggcaccaa gcgggctcaa ggcagtcgtg ggagaaaaaa tcctcagcgg agtcatcaga       60

agtgtgaaga aagacgggga gtggaaagtg ctgatcatgg accaccccag catgagaatc      120

ctgagctcct gctgcaagat gtccgacatc ctggctgaag gcatcaccat cgtggaggac      180

atcaataaga ggagagaacc catcccaagc ctggaggcca tctacctgct gtccccaacc      240

gagaaggctc aggctcagag agtgatccac ctgccacaga gcgtgcaggc tctgatcaag      300

gatttccagg gcacccccac cttcacctac aaggccgctc acatcttctt caccgacacc      360

tgccccgaac cactgttcag cgagctgggc aggtccagac tggccaaggt ggtgaagacc      420

ctgaaggaaa tccacctggc tttcctgcca tacgaggccc aggtgttcag cctggatgct      480

ccccactcca cctacaatct gtactgccca ttcagggccg aggaaaggac cagacagctg      540

gaagtgctgg cccagcagat cgctaccctg tgcgccaccc tgcaggaata ccccgccatc      600

aggtacagaa agggcccaga ggataccgct cagctggctc acgctgtgct ggctaagctg      660

aacgccttca aggctgacac cccaagcctg ggggagggac cagaaaagac caggtcccag      720

ctgctgatca tggatagggc tgctgacccc gtgagcccac tgctgcacga gctgaccttc      780

caggctatgg cctacgatct gctggacatc gaacaggaca cctacagata cgaaaccacc      840

ggcctgtccg aggctagaga aaaggccgtg ctgctggatg aagacgatga cctgtgggtg      900

gagctgaggc acatgcacat cgctgacgtg agcaagaagg tgaccgaact gctgaggacc      960

ttctgcgagt ccaagagact gaccaccgat aaggccaata tcaaggacct gagccagatc     1020

ctgaagaaga tgccccagta ccagaaggag ctgaacaagt actccaccca cctgcacctg     1080

gctgatgact gcatgaagca cttcaagggc agcgtggaaa agctgtgctc cgtggagcag     1140

gatctggcta tgggcagcga cgccgagggc gaaaagatca aggattccat gaagctgatc     1200

gtgccagtgc tgctggatgc tgctgtgcca gcttacgaca agatcagggt gctgctgctg     1260

tacatcctgc tgagaaacgg cgtgagcgag gaaaatctgg ccaagctgat ccagcacgct     1320

aacgtgcagg cccacagctc cctgatcagg aatctggagc agctgggcgg caccgtgacc     1380

aatccaggcg gcagcggaac cagctccagg ctggagccca gggaaagaat ggagccaacc     1440

taccagctgt ccagatggac ccccgtgatc aaggatgtga tggaagacgc cgtggaggat     1500

aggctggaca gaaatctgtg gcccttcgtg agcgaccccg ctccaaccgc tagctcccag     1560

gctgctgtgt ccgctagatt cggccactgg cacaagaaca aggctggaat cgaggctagg     1620

gctggaccaa gactgatcgt gtacgtgatg ggcggcgtgg ctatgagcga aatgagggcc     1680

gcttacgagg tgaccagagc caccgagggc aagtgggagg tgctgatcgg cagctcccac     1740

atcctgaccc caaccagatt tctggacgac ctcaaagccc tggacaaaaa actggaagac     1800

atcgctctgc cctaa                                                      1815


<210>  3
<211>  1090
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  3

Met Ala Thr Leu Leu Ser His Pro Gln Gln Arg Pro Pro Phe Leu Arg 
1               5                   10                  15      


Gln Ala Ile Lys Ile Arg Arg Arg Arg Val Arg Asp Leu Gln Asp Pro 
            20                  25                  30          


Pro Pro Gln Met Ala Pro Glu Ile Gln Pro Pro Ser His His Phe Ser 
        35                  40                  45              


Pro Glu Gln Arg Ala Leu Leu Tyr Glu Asp Ala Leu Tyr Thr Val Leu 
    50                  55                  60                  


His Arg Leu Gly His Pro Glu Pro Asn His Val Thr Glu Ala Ser Glu 
65                  70                  75                  80  


Leu Leu Arg Tyr Leu Gln Glu Ala Phe His Val Glu Pro Glu Glu His 
                85                  90                  95      


Gln Gln Thr Leu Gln Arg Val Arg Glu Leu Glu Lys Pro Ile Phe Cys 
            100                 105                 110         


Leu Lys Ala Thr Val Lys Gln Ala Lys Gly Ile Leu Gly Lys Asp Val 
        115                 120                 125             


Ser Gly Phe Ser Asp Pro Tyr Cys Leu Leu Gly Ile Glu Gln Gly Val 
    130                 135                 140                 


Gly Val Pro Gly Gly Ser Pro Gly Ser Arg His Arg Gln Lys Ala Val 
145                 150                 155                 160 


Val Arg His Thr Ile Pro Glu Glu Glu Thr His Arg Thr Gln Val Ile 
                165                 170                 175     


Thr Gln Thr Leu Asn Pro Val Trp Asp Glu Thr Phe Ile Leu Glu Phe 
            180                 185                 190         


Glu Asp Ile Thr Asn Ala Ser Phe His Leu Asp Met Trp Asp Leu Asp 
        195                 200                 205             


Thr Val Glu Ser Val Arg Gln Lys Leu Gly Glu Leu Thr Asp Leu His 
    210                 215                 220                 


Gly Leu Arg Arg Ile Phe Lys Glu Ala Arg Lys Asp Lys Gly Gln Asp 
225                 230                 235                 240 


Asp Phe Leu Gly Asn Val Val Leu Arg Leu Gln Asp Leu Arg Cys Arg 
                245                 250                 255     


Glu Asp Gln Trp Tyr Pro Leu Glu Pro Arg Thr Glu Thr Tyr Pro Asp 
            260                 265                 270         


Arg Gly Gln Cys His Leu Gln Phe Gln Leu Ile His Lys Arg Arg Ala 
        275                 280                 285             


Thr Ser Ala Ser Arg Ser Gln Pro Ser Tyr Thr Val His Leu His Leu 
    290                 295                 300                 


Leu Gln Gln Leu Val Ser His Glu Val Thr Gln His Glu Ala Gly Ser 
305                 310                 315                 320 


Thr Ser Trp Asp Gly Ser Leu Ser Pro Gln Ala Ala Thr Val Leu Phe 
                325                 330                 335     


Leu His Ala Thr Gln Lys Asp Leu Ser Asp Phe His Gln Ser Met Ala 
            340                 345                 350         


Gln Trp Leu Ala Tyr Ser Arg Leu Tyr Gln Ser Leu Glu Phe Pro Ser 
        355                 360                 365             


Ser Cys Leu Leu His Pro Ile Thr Ser Ile Glu Tyr Gln Trp Ile Gln 
    370                 375                 380                 


Gly Arg Leu Lys Ala Glu Gln Gln Glu Glu Leu Ala Ala Ser Phe Ser 
385                 390                 395                 400 


Ser Leu Leu Thr Tyr Gly Leu Ser Leu Ile Arg Arg Phe Arg Ser Val 
                405                 410                 415     


Phe Pro Leu Ser Val Ser Asp Ser Pro Ala Arg Leu Gln Ser Leu Leu 
            420                 425                 430         


Arg Val Leu Val Gln Met Cys Lys Met Lys Ala Phe Gly Glu Leu Cys 
        435                 440                 445             


Pro Asn Thr Ala Pro Leu Pro Gln Leu Val Thr Glu Ala Leu Gln Thr 
    450                 455                 460                 


Gly Thr Thr Glu Trp Phe His Leu Lys Gln Gln His His Gln Pro Met 
465                 470                 475                 480 


Val Gln Gly Ile Pro Glu Ala Gly Lys Ala Leu Leu Gly Leu Val Gln 
                485                 490                 495     


Asp Val Ile Gly Asp Leu His Gln Cys Gln Arg Thr Trp Asp Lys Ile 
            500                 505                 510         


Phe His Asn Thr Leu Lys Ile His Leu Phe Ser Met Ala Phe Arg Glu 
        515                 520                 525             


Leu Gln Trp Leu Val Ala Lys Arg Val Gln Asp His Thr Thr Val Val 
    530                 535                 540                 


Gly Asp Val Val Ser Pro Glu Met Gly Glu Ser Leu Phe Gln Leu Tyr 
545                 550                 555                 560 


Ile Ser Leu Lys Glu Leu Cys Gln Leu Arg Met Ser Ser Ser Glu Arg 
                565                 570                 575     


Asp Gly Val Leu Ala Leu Asp Asn Phe His Arg Trp Phe Gln Pro Ala 
            580                 585                 590         


Ile Pro Ser Trp Leu Gln Lys Thr Tyr Asn Glu Ala Leu Ala Arg Val 
        595                 600                 605             


Gln Arg Ala Val Gln Met Asp Glu Leu Val Pro Leu Gly Glu Leu Thr 
    610                 615                 620                 


Lys His Ser Thr Ser Ala Val Asp Leu Ser Thr Cys Phe Ala Gln Ile 
625                 630                 635                 640 


Ser His Thr Ala Arg Gln Leu Asp Trp Pro Asp Pro Glu Glu Ala Phe 
                645                 650                 655     


Met Ile Thr Val Lys Phe Val Glu Asp Thr Cys Arg Leu Ala Leu Val 
            660                 665                 670         


Tyr Cys Ser Leu Ile Lys Ala Arg Ala Arg Glu Leu Ser Ser Gly Gln 
        675                 680                 685             


Lys Asp Gln Gly Gln Ala Ala Asn Met Leu Cys Val Val Val Asn Asp 
    690                 695                 700                 


Met Glu Gln Leu Arg Leu Val Ile Gly Lys Leu Pro Ala Gln Leu Ala 
705                 710                 715                 720 


Trp Glu Ala Leu Glu Gln Arg Val Gly Ala Val Leu Glu Gln Gly Gln 
                725                 730                 735     


Leu Gln Asn Thr Leu His Ala Gln Leu Gln Ser Ala Leu Ala Gly Leu 
            740                 745                 750         


Gly His Glu Ile Arg Thr Gly Val Arg Thr Leu Ala Glu Gln Leu Glu 
        755                 760                 765             


Val Gly Ile Ala Lys His Ile Gln Lys Leu Val Gly Val Arg Glu Ser 
    770                 775                 780                 


Val Leu Pro Glu Asp Ala Ile Leu Pro Leu Met Lys Phe Leu Glu Val 
785                 790                 795                 800 


Glu Leu Cys Tyr Met Asn Thr Asn Leu Val Gln Glu Asn Phe Ser Ser 
                805                 810                 815     


Leu Leu Thr Leu Leu Trp Thr His Thr Leu Thr Val Leu Val Glu Ala 
            820                 825                 830         


Ala Ala Ser Gln Arg Ser Ser Ser Leu Ala Ser Asn Arg Leu Lys Ile 
        835                 840                 845             


Ala Leu Gln Asn Leu Glu Ile Cys Phe His Ala Glu Gly Cys Gly Leu 
    850                 855                 860                 


Pro Pro Lys Ala Leu His Thr Ala Thr Phe Gln Ala Leu Gln Arg Asp 
865                 870                 875                 880 


Leu Glu Leu Gln Ala Ala Ser Ser Arg Glu Leu Ile Arg Lys Tyr Phe 
                885                 890                 895     


Cys Ser Arg Ile Gln Gln Gln Ala Glu Thr Thr Ser Glu Glu Leu Gly 
            900                 905                 910         


Ala Val Thr Val Lys Ala Ser Tyr Arg Ala Ser Glu Gln Lys Leu Arg 
        915                 920                 925             


Val Glu Leu Leu Ser Ala Ser Ser Leu Leu Pro Leu Asp Ser Asn Gly 
    930                 935                 940                 


Ser Ser Asp Pro Phe Val Gln Leu Thr Leu Glu Pro Arg His Glu Phe 
945                 950                 955                 960 


Pro Glu Leu Ala Ala Arg Glu Thr Gln Lys His Lys Lys Asp Leu His 
                965                 970                 975     


Pro Leu Phe Asp Glu Thr Phe Glu Phe Leu Val Pro Ala Glu Pro Cys 
            980                 985                 990         


Arg Lys Ala Gly Ala Cys Leu Leu  Leu Thr Val Leu Asp  Tyr Asp Thr 
        995                 1000                 1005             


Leu Gly  Ala Asp Asp Leu Glu  Gly Glu Ala Phe Leu  Pro Leu Arg 
    1010                 1015                 1020             


Glu Val  Pro Gly Leu Ser Gly  Ser Glu Glu Pro Gly  Glu Val Pro 
    1025                 1030                 1035             


Gln Thr  Arg Leu Pro Leu Thr  Tyr Pro Ala Pro Asn  Gly Asp Pro 
    1040                 1045                 1050             


Ile Leu  Gln Leu Leu Glu Gly  Arg Lys Gly Asp Arg  Glu Ala Gln 
    1055                 1060                 1065             


Val Phe  Val Arg Leu Arg Arg  His Arg Ala Lys Gln  Ala Ser Gln 
    1070                 1075                 1080             


His Ala  Leu Arg Pro Ala Pro  
    1085                 1090 


<210>  4
<211>  604
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  4

Met Ala Pro Ser Gly Leu Lys Ala Val Val Gly Glu Lys Ile Leu Ser 
1               5                   10                  15      


Gly Val Ile Arg Ser Val Lys Lys Asp Gly Glu Trp Lys Val Leu Ile 
            20                  25                  30          


Met Asp His Pro Ser Met Arg Ile Leu Ser Ser Cys Cys Lys Met Ser 
        35                  40                  45              


Asp Ile Leu Ala Glu Gly Ile Thr Ile Val Glu Asp Ile Asn Lys Arg 
    50                  55                  60                  


Arg Glu Pro Ile Pro Ser Leu Glu Ala Ile Tyr Leu Leu Ser Pro Thr 
65                  70                  75                  80  


Glu Lys Ala Gln Ala Gln Arg Val Ile His Leu Pro Gln Ser Val Gln 
                85                  90                  95      


Ala Leu Ile Lys Asp Phe Gln Gly Thr Pro Thr Phe Thr Tyr Lys Ala 
            100                 105                 110         


Ala His Ile Phe Phe Thr Asp Thr Cys Pro Glu Pro Leu Phe Ser Glu 
        115                 120                 125             


Leu Gly Arg Ser Arg Leu Ala Lys Val Val Lys Thr Leu Lys Glu Ile 
    130                 135                 140                 


His Leu Ala Phe Leu Pro Tyr Glu Ala Gln Val Phe Ser Leu Asp Ala 
145                 150                 155                 160 


Pro His Ser Thr Tyr Asn Leu Tyr Cys Pro Phe Arg Ala Glu Glu Arg 
                165                 170                 175     


Thr Arg Gln Leu Glu Val Leu Ala Gln Gln Ile Ala Thr Leu Cys Ala 
            180                 185                 190         


Thr Leu Gln Glu Tyr Pro Ala Ile Arg Tyr Arg Lys Gly Pro Glu Asp 
        195                 200                 205             


Thr Ala Gln Leu Ala His Ala Val Leu Ala Lys Leu Asn Ala Phe Lys 
    210                 215                 220                 


Ala Asp Thr Pro Ser Leu Gly Glu Gly Pro Glu Lys Thr Arg Ser Gln 
225                 230                 235                 240 


Leu Leu Ile Met Asp Arg Ala Ala Asp Pro Val Ser Pro Leu Leu His 
                245                 250                 255     


Glu Leu Thr Phe Gln Ala Met Ala Tyr Asp Leu Leu Asp Ile Glu Gln 
            260                 265                 270         


Asp Thr Tyr Arg Tyr Glu Thr Thr Gly Leu Ser Glu Ala Arg Glu Lys 
        275                 280                 285             


Ala Val Leu Leu Asp Glu Asp Asp Asp Leu Trp Val Glu Leu Arg His 
    290                 295                 300                 


Met His Ile Ala Asp Val Ser Lys Lys Val Thr Glu Leu Leu Arg Thr 
305                 310                 315                 320 


Phe Cys Glu Ser Lys Arg Leu Thr Thr Asp Lys Ala Asn Ile Lys Asp 
                325                 330                 335     


Leu Ser Gln Ile Leu Lys Lys Met Pro Gln Tyr Gln Lys Glu Leu Asn 
            340                 345                 350         


Lys Tyr Ser Thr His Leu His Leu Ala Asp Asp Cys Met Lys His Phe 
        355                 360                 365             


Lys Gly Ser Val Glu Lys Leu Cys Ser Val Glu Gln Asp Leu Ala Met 
    370                 375                 380                 


Gly Ser Asp Ala Glu Gly Glu Lys Ile Lys Asp Ser Met Lys Leu Ile 
385                 390                 395                 400 


Val Pro Val Leu Leu Asp Ala Ala Val Pro Ala Tyr Asp Lys Ile Arg 
                405                 410                 415     


Val Leu Leu Leu Tyr Ile Leu Leu Arg Asn Gly Val Ser Glu Glu Asn 
            420                 425                 430         


Leu Ala Lys Leu Ile Gln His Ala Asn Val Gln Ala His Ser Ser Leu 
        435                 440                 445             


Ile Arg Asn Leu Glu Gln Leu Gly Gly Thr Val Thr Asn Pro Gly Gly 
    450                 455                 460                 


Ser Gly Thr Ser Ser Arg Leu Glu Pro Arg Glu Arg Met Glu Pro Thr 
465                 470                 475                 480 


Tyr Gln Leu Ser Arg Trp Thr Pro Val Ile Lys Asp Val Met Glu Asp 
                485                 490                 495     


Ala Val Glu Asp Arg Leu Asp Arg Asn Leu Trp Pro Phe Val Ser Asp 
            500                 505                 510         


Pro Ala Pro Thr Ala Ser Ser Gln Ala Ala Val Ser Ala Arg Phe Gly 
        515                 520                 525             


His Trp His Lys Asn Lys Ala Gly Ile Glu Ala Arg Ala Gly Pro Arg 
    530                 535                 540                 


Leu Ile Val Tyr Val Met Gly Gly Val Ala Met Ser Glu Met Arg Ala 
545                 550                 555                 560 


Ala Tyr Glu Val Thr Arg Ala Thr Glu Gly Lys Trp Glu Val Leu Ile 
                565                 570                 575     


Gly Ser Ser His Ile Leu Thr Pro Thr Arg Phe Leu Asp Asp Leu Lys 
            580                 585                 590         


Ala Leu Asp Lys Lys Leu Glu Asp Ile Ala Leu Pro 
        595                 600                 


<210>  5
<211>  3273
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  5
atggcgacac tcctctccca tccgcagcag cgccctccct tcttgcgcca ggccatcaag       60

ataaggcgcc gcagagtcag agatctacag gatcccccgc cccaaatggc cccggagatc      120

cagcctccat cccaccactt ctcccccgag cagcgggccc tgctctacga ggacgcactc      180

tacactgtct tgcaccgcct gggtcatcct gagcccaacc atgtgacgga ggcctctgag      240

ctgctgcgat acctgcagga ggccttccac gtggagcccg aggagcacca gcagacactg      300

cagcgggtca gggagcttga gaagccaata ttttgtctga aggcaacagt gaaacaggcc      360

aagggcattc tgggcaaaga tgtcagtggg ttcagcgacc cctactgcct gctgggcatt      420

gagcaggggg taggtgtgcc agggggcagc cccgggtccc ggcatcggca gaaggctgtg      480

gtgaggcaca ccatccccga ggaggagacc caccgcacgc aggtcatcac ccagacactc      540

aaccccgtct gggacgagac cttcatcctg gagtttgagg acatcaccaa tgcgagcttt      600

catctggaca tgtgggacct ggacactgtg gagtctgtcc gacagaagct tggggagctc      660

acggatctgc atgggcttcg caggatcttt aaagaggccc ggaaggacaa aggccaggac      720

gactttctgg ggaacgtggt tctgaggctg caggacctgc gctgccgaga ggaccagtgg      780

taccccctgg aaccccgcac tgagacctac ccagaccgag gccagtgcca cctccagttc      840

caactcatcc ataagcggag agccacttcg gccagccgct cgcagccgag ctacaccgtg      900

cacctccacc tcctgcagca gcttgtgtcc cacgaggtca cccagcacga ggcgggaagc      960

acctcctggg acgggtcgct gagtccccag gctgccaccg tcctctttct gcacgccaca     1020

cagaaggacc tatccgactt ccaccagtcc atggcgcagt ggctggccta cagccgcctc     1080

taccagagcc tggagttccc cagcagctgc ctcctgcacc ccatcaccag catcgagtac     1140

cagtggatcc agggtcggct caaggcagaa cagcaggagg agctggccgc ctcattcagc     1200

tccctgctga cctacggcct ctccctcatc cggaggttcc gctctgtctt ccccctctct     1260

gtctcggact ccccagcccg gctgcagtct cttctcaggg tcctggtaca gatgtgcaag     1320

atgaaggcct ttggagaact gtgccccaac accgccccat tgccccagct ggtgactgag     1380

gccctgcaga ctggcaccac tgaatggttc cacctgaagc agcagcacca tcaacccatg     1440

gtgcagggca tcccggaggc aggcaaggcc ttgctgggcc tggtacagga tgtcattggc     1500

gacctgcacc agtgccagcg cacatgggac aagatcttcc acaataccct caagatccac     1560

ctcttctcca tggctttccg ggagctgcag tggctggtgg ccaagcgggt gcaggaccac     1620

acgacggttg tgggtgatgt agtgtcccca gagatgggcg agagtctgtt ccagctctac     1680

atcagcctca aggagctctg ccagctgcgc atgagctcct cagagaggga tggagtcctg     1740

gccctggata atttccaccg ctggttccag ccggccatcc cctcctggct gcagaagacg     1800

tacaacgagg ccctggcgcg ggtgcagcgc gctgtgcaga tggatgagct ggtgcccctg     1860

ggtgaactga ccaagcacag cacatcagcg gtggatctat ccacctgctt tgcccagatc     1920

agccacactg cccggcagct ggactggcca gacccagagg aggccttcat gattaccgtc     1980

aagtttgtgg aggacacctg tcgcctggcc ctggtgtact gcagccttat aaaggcccgg     2040

gcccgcgagc tctcttcagg ccagaaggac caaggccagg cagccaacat gctgtgtgtg     2100

gtggtgaatg acatggagca gctgcggctg gtgatcggca agttgcccgc ccagctggca     2160

tgggaggccc tggagcagcg ggtaggggcc gtgctggagc aggggcagct gcagaacacg     2220

ctgcatgccc agctgcagag cgcgctggcc gggctgggcc atgagatccg cactggcgtc     2280

cgcaccctgg ccgagcagtt ggaggtgggc atcgccaagc acatccagaa actggtgggc     2340

gtcagggagt ctgtcctgcc tgaggatgcc attctgcccc tgatgaagtt cctggaggtg     2400

gagctttgct acatgaacac caacttggtg caggagaact tcagcagcct cctgaccctg     2460

ctctggaccc acacactcac agtgctggtg gaggcggccg cctcccagcg cagctcatcc     2520

ctggcttcca acaggctgaa gattgccctg cagaacctgg agatctgctt ccacgctgag     2580

ggctgtggcc tgccacccaa ggccctgcac actgccacct tccaggctct gcagagggac     2640

ctggagctgc aggcggcctc cagccgggaa ctcatccgga agtacttctg cagccgaatc     2700

cagcagcagg cagaaaccac ctctgaggag ctgggggctg tgacagtcaa ggcctcctac     2760

cgcgcctctg agcagaagct gcgtgtggag ctgctcagcg cctccagcct gctgcccctg     2820

gactccaatg gctccagcga cccctttgtc cagctgacct tggagcccag gcatgagttc     2880

cctgagctgg ccgcccggga gacccagaag cacaagaagg accttcaccc attgtttgat     2940

gagacctttg aattcctggt gcctgctgag ccgtgccgca aggctggggc atgcctcctg     3000

ctcaccgtgc tggactacga cacgctgggg gccgacgacc tggaaggcga ggccttcctg     3060

ccgctgcgtg aggtgcccgg gctgagtggc tctgaggagc ctggtgaggt gcctcagacc     3120

cgcctgcccc tcacgtaccc cgcacccaac ggggacccaa tcctgcagct gctggagggc     3180

cggaagggtg accgagaagc ccaggtcttt gtgaggctgc ggcggcaccg ggccaagcag     3240

gcctcccagc atgccttgcg gccggcaccg tag                                  3273


<210>  6
<211>  1090
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  6

Met Ala Thr Leu Leu Ser His Pro Gln Gln Arg Pro Pro Phe Leu Arg 
1               5                   10                  15      


Gln Ala Ile Lys Ile Arg Arg Arg Arg Val Arg Asp Leu Gln Asp Pro 
            20                  25                  30          


Pro Pro Gln Met Ala Pro Glu Ile Gln Pro Pro Ser His His Phe Ser 
        35                  40                  45              


Pro Glu Gln Arg Ala Leu Leu Tyr Glu Asp Ala Leu Tyr Thr Val Leu 
    50                  55                  60                  


His Arg Leu Gly His Pro Glu Pro Asn His Val Thr Glu Ala Ser Glu 
65                  70                  75                  80  


Leu Leu Arg Tyr Leu Gln Glu Ala Phe His Val Glu Pro Glu Glu His 
                85                  90                  95      


Gln Gln Thr Leu Gln Arg Val Arg Glu Leu Glu Lys Pro Ile Phe Cys 
            100                 105                 110         


Leu Lys Ala Thr Val Lys Gln Ala Lys Gly Ile Leu Gly Lys Asp Val 
        115                 120                 125             


Ser Gly Phe Ser Asp Pro Tyr Cys Leu Leu Gly Ile Glu Gln Gly Val 
    130                 135                 140                 


Gly Val Pro Gly Gly Ser Pro Gly Ser Arg His Arg Gln Lys Ala Val 
145                 150                 155                 160 


Val Arg His Thr Ile Pro Glu Glu Glu Thr His Arg Thr Gln Val Ile 
                165                 170                 175     


Thr Gln Thr Leu Asn Pro Val Trp Asp Glu Thr Phe Ile Leu Glu Phe 
            180                 185                 190         


Glu Asp Ile Thr Asn Ala Ser Phe His Leu Asp Met Trp Asp Leu Asp 
        195                 200                 205             


Thr Val Glu Ser Val Arg Gln Lys Leu Gly Glu Leu Thr Asp Leu His 
    210                 215                 220                 


Gly Leu Arg Arg Ile Phe Lys Glu Ala Arg Lys Asp Lys Gly Gln Asp 
225                 230                 235                 240 


Asp Phe Leu Gly Asn Val Val Leu Arg Leu Gln Asp Leu Arg Cys Arg 
                245                 250                 255     


Glu Asp Gln Trp Tyr Pro Leu Glu Pro Arg Thr Glu Thr Tyr Pro Asp 
            260                 265                 270         


Arg Gly Gln Cys His Leu Gln Phe Gln Leu Ile His Lys Arg Arg Ala 
        275                 280                 285             


Thr Ser Ala Ser Arg Ser Gln Pro Ser Tyr Thr Val His Leu His Leu 
    290                 295                 300                 


Leu Gln Gln Leu Val Ser His Glu Val Thr Gln His Glu Ala Gly Ser 
305                 310                 315                 320 


Thr Ser Trp Asp Gly Ser Leu Ser Pro Gln Ala Ala Thr Val Leu Phe 
                325                 330                 335     


Leu His Ala Thr Gln Lys Asp Leu Ser Asp Phe His Gln Ser Met Ala 
            340                 345                 350         


Gln Trp Leu Ala Tyr Ser Arg Leu Tyr Gln Ser Leu Glu Phe Pro Ser 
        355                 360                 365             


Ser Cys Leu Leu His Pro Ile Thr Ser Ile Glu Tyr Gln Trp Ile Gln 
    370                 375                 380                 


Gly Arg Leu Lys Ala Glu Gln Gln Glu Glu Leu Ala Ala Ser Phe Ser 
385                 390                 395                 400 


Ser Leu Leu Thr Tyr Gly Leu Ser Leu Ile Arg Arg Phe Arg Ser Val 
                405                 410                 415     


Phe Pro Leu Ser Val Ser Asp Ser Pro Ala Arg Leu Gln Ser Leu Leu 
            420                 425                 430         


Arg Val Leu Val Gln Met Cys Lys Met Lys Ala Phe Gly Glu Leu Cys 
        435                 440                 445             


Pro Asn Thr Ala Pro Leu Pro Gln Leu Val Thr Glu Ala Leu Gln Thr 
    450                 455                 460                 


Gly Thr Thr Glu Trp Phe His Leu Lys Gln Gln His His Gln Pro Met 
465                 470                 475                 480 


Val Gln Gly Ile Pro Glu Ala Gly Lys Ala Leu Leu Gly Leu Val Gln 
                485                 490                 495     


Asp Val Ile Gly Asp Leu His Gln Cys Gln Arg Thr Trp Asp Lys Ile 
            500                 505                 510         


Phe His Asn Thr Leu Lys Ile His Leu Phe Ser Met Ala Phe Arg Glu 
        515                 520                 525             


Leu Gln Trp Leu Val Ala Lys Arg Val Gln Asp His Thr Thr Val Val 
    530                 535                 540                 


Gly Asp Val Val Ser Pro Glu Met Gly Glu Ser Leu Phe Gln Leu Tyr 
545                 550                 555                 560 


Ile Ser Leu Lys Glu Leu Cys Gln Leu Arg Met Ser Ser Ser Glu Arg 
                565                 570                 575     


Asp Gly Val Leu Ala Leu Asp Asn Phe His Arg Trp Phe Gln Pro Ala 
            580                 585                 590         


Ile Pro Ser Trp Leu Gln Lys Thr Tyr Asn Glu Ala Leu Ala Arg Val 
        595                 600                 605             


Gln Arg Ala Val Gln Met Asp Glu Leu Val Pro Leu Gly Glu Leu Thr 
    610                 615                 620                 


Lys His Ser Thr Ser Ala Val Asp Leu Ser Thr Cys Phe Ala Gln Ile 
625                 630                 635                 640 


Ser His Thr Ala Arg Gln Leu Asp Trp Pro Asp Pro Glu Glu Ala Phe 
                645                 650                 655     


Met Ile Thr Val Lys Phe Val Glu Asp Thr Cys Arg Leu Ala Leu Val 
            660                 665                 670         


Tyr Cys Ser Leu Ile Lys Ala Arg Ala Arg Glu Leu Ser Ser Gly Gln 
        675                 680                 685             


Lys Asp Gln Gly Gln Ala Ala Asn Met Leu Cys Val Val Val Asn Asp 
    690                 695                 700                 


Met Glu Gln Leu Arg Leu Val Ile Gly Lys Leu Pro Ala Gln Leu Ala 
705                 710                 715                 720 


Trp Glu Ala Leu Glu Gln Arg Val Gly Ala Val Leu Glu Gln Gly Gln 
                725                 730                 735     


Leu Gln Asn Thr Leu His Ala Gln Leu Gln Ser Ala Leu Ala Gly Leu 
            740                 745                 750         


Gly His Glu Ile Arg Thr Gly Val Arg Thr Leu Ala Glu Gln Leu Glu 
        755                 760                 765             


Val Gly Ile Ala Lys His Ile Gln Lys Leu Val Gly Val Arg Glu Ser 
    770                 775                 780                 


Val Leu Pro Glu Asp Ala Ile Leu Pro Leu Met Lys Phe Leu Glu Val 
785                 790                 795                 800 


Glu Leu Cys Tyr Met Asn Thr Asn Leu Val Gln Glu Asn Phe Ser Ser 
                805                 810                 815     


Leu Leu Thr Leu Leu Trp Thr His Thr Leu Thr Val Leu Val Glu Ala 
            820                 825                 830         


Ala Ala Ser Gln Arg Ser Ser Ser Leu Ala Ser Asn Arg Leu Lys Ile 
        835                 840                 845             


Ala Leu Gln Asn Leu Glu Ile Cys Phe His Ala Glu Gly Cys Gly Leu 
    850                 855                 860                 


Pro Pro Lys Ala Leu His Thr Ala Thr Phe Gln Ala Leu Gln Arg Asp 
865                 870                 875                 880 


Leu Glu Leu Gln Ala Ala Ser Ser Arg Glu Leu Ile Arg Lys Tyr Phe 
                885                 890                 895     


Cys Ser Arg Ile Gln Gln Gln Ala Glu Thr Thr Ser Glu Glu Leu Gly 
            900                 905                 910         


Ala Val Thr Val Lys Ala Ser Tyr Arg Ala Ser Glu Gln Lys Leu Arg 
        915                 920                 925             


Val Glu Leu Leu Ser Ala Ser Ser Leu Leu Pro Leu Asp Ser Asn Gly 
    930                 935                 940                 


Ser Ser Asp Pro Phe Val Gln Leu Thr Leu Glu Pro Arg His Glu Phe 
945                 950                 955                 960 


Pro Glu Leu Ala Ala Arg Glu Thr Gln Lys His Lys Lys Asp Leu His 
                965                 970                 975     


Pro Leu Phe Asp Glu Thr Phe Glu Phe Leu Val Pro Ala Glu Pro Cys 
            980                 985                 990         


Arg Lys Ala Gly Ala Cys Leu Leu  Leu Thr Val Leu Asp  Tyr Asp Thr 
        995                 1000                 1005             


Leu Gly  Ala Asp Asp Leu Glu  Gly Glu Ala Phe Leu  Pro Leu Arg 
    1010                 1015                 1020             


Glu Val  Pro Gly Leu Ser Gly  Ser Glu Glu Pro Gly  Glu Val Pro 
    1025                 1030                 1035             


Gln Thr  Arg Leu Pro Leu Thr  Tyr Pro Ala Pro Asn  Gly Asp Pro 
    1040                 1045                 1050             


Ile Leu  Gln Leu Leu Glu Gly  Arg Lys Gly Asp Arg  Glu Ala Gln 
    1055                 1060                 1065             


Val Phe  Val Arg Leu Arg Arg  His Arg Ala Lys Gln  Ala Ser Gln 
    1070                 1075                 1080             


His Ala  Leu Arg Pro Ala Pro  
    1085                 1090 


<210>  7
<211>  1815
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  7
atggcgccct cggggctgaa ggcggtggtg ggggaaaaaa ttctgagcgg agttattcgg       60

agtgtcaaga aggatgggga gtggaaggtg cttatcatgg atcacccaag catgcgcatc      120

ttgtcttcct gctgcaaaat gtcagatatc ctggctgagg gcatcaccat tgttgaagac      180

atcaacaaac ggcgggaacc cattcccagt ctggaggcca tttatttgct gagccccacg      240

gagaaggctc aggcccagag agtgatccac cttccccagt cggttcaggc cctgatcaaa      300

gacttccagg ggaccccgac tttcacctac aaagcggccc atatcttctt caccgacacc      360

tgccccgagc ccctgttcag tgagctaggc cgctctcgtc tggcaaaggt ggtgaagacg      420

ttgaaggaga ttcaccttgc cttcctcccc tacgaggccc aggtgttctc cctcgatgct      480

ccccacagca cctacaacct ctactgcccc ttccgggcag aggagcgcac gcggcagctc      540

gaggtgctgg cccagcagat tgccacgctg tgcgccaccc tgcaggagta cccggccatc      600

cgctaccgca agggcccaga ggacacagcc cagttggccc acgccgtcct ggccaagctg      660

aacgccttca aggcagacac tcccagtctg ggcgagggcc cagagaaaac ccgctcccag      720

ctgctgataa tggaccgggc agctgacccc gtgtccccac tactgcatga gctcacgttc      780

caggccatgg cgtatgatct gctggacata gagcaggaca catacaggta tgagaccacc      840

gggctgagcg aggcgcggga gaaggccgtc ttgctggacg aggacgatga cttgtgggtg      900

gagcttcgcc acatgcatat cgcagatgtg tccaagaagg tcacggagct cctgaggacc      960

ttctgtgaga gcaagaggct gaccacggac aaggcgaaca tcaaagacct atcccagatc     1020

ctgaaaaaga tgccgcagta ccagaaggag ctgaataagt attctacgca cctgcatcta     1080

gcagatgatt gtatgaagca cttcaagggc tcggtggaga agctgtgtag tgtggagcag     1140

gacctggcca tgggctccga cgcagagggg gagaagatca aggactccat gaagctgatc     1200

gttccggtgc tgctggacgc ggcggtgccc gcctacgaca agatccgggt cctgctgctc     1260

tacatcctcc ttcggaatgg tgtgagtgag gagaacctgg ccaagctgat ccagcatgcc     1320

aatgtacagg cgcacagcag cctcatccgt aacctggagc agctgggagg cactgtcacc     1380

aaccccgggg gctcggggac ctccagccgg ctggagccga gagaacgcat ggagcccacc     1440

tatcagctgt cccgctggac cccggtcatc aaggatgtaa tggaggacgc cgtggaggac     1500

cggctggaca ggaacctgtg gcccttcgta tccgaccccg cccccacggc cagctcccag     1560

gccgctgtca gtgcccgctt cggtcactgg cacaagaaca aggctggcat agaagcccgg     1620

gcgggccccc ggctcatcgt gtatgtcatg ggcggtgtgg ccatgtcaga gatgagggcc     1680

gcctacgagg tgaccagggc caccgagggc aagtgggagg tgctcattgg ctcctcacac     1740

atcctcaccc cgacccgctt cctggatgac ctgaaggcac tggacaagaa gctggaggac     1800

attgccctgc cctga                                                      1815


<210>  8
<211>  604
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  8

Met Ala Pro Ser Gly Leu Lys Ala Val Val Gly Glu Lys Ile Leu Ser 
1               5                   10                  15      


Gly Val Ile Arg Ser Val Lys Lys Asp Gly Glu Trp Lys Val Leu Ile 
            20                  25                  30          


Met Asp His Pro Ser Met Arg Ile Leu Ser Ser Cys Cys Lys Met Ser 
        35                  40                  45              


Asp Ile Leu Ala Glu Gly Ile Thr Ile Val Glu Asp Ile Asn Lys Arg 
    50                  55                  60                  


Arg Glu Pro Ile Pro Ser Leu Glu Ala Ile Tyr Leu Leu Ser Pro Thr 
65                  70                  75                  80  


Glu Lys Ala Gln Ala Gln Arg Val Ile His Leu Pro Gln Ser Val Gln 
                85                  90                  95      


Ala Leu Ile Lys Asp Phe Gln Gly Thr Pro Thr Phe Thr Tyr Lys Ala 
            100                 105                 110         


Ala His Ile Phe Phe Thr Asp Thr Cys Pro Glu Pro Leu Phe Ser Glu 
        115                 120                 125             


Leu Gly Arg Ser Arg Leu Ala Lys Val Val Lys Thr Leu Lys Glu Ile 
    130                 135                 140                 


His Leu Ala Phe Leu Pro Tyr Glu Ala Gln Val Phe Ser Leu Asp Ala 
145                 150                 155                 160 


Pro His Ser Thr Tyr Asn Leu Tyr Cys Pro Phe Arg Ala Glu Glu Arg 
                165                 170                 175     


Thr Arg Gln Leu Glu Val Leu Ala Gln Gln Ile Ala Thr Leu Cys Ala 
            180                 185                 190         


Thr Leu Gln Glu Tyr Pro Ala Ile Arg Tyr Arg Lys Gly Pro Glu Asp 
        195                 200                 205             


Thr Ala Gln Leu Ala His Ala Val Leu Ala Lys Leu Asn Ala Phe Lys 
    210                 215                 220                 


Ala Asp Thr Pro Ser Leu Gly Glu Gly Pro Glu Lys Thr Arg Ser Gln 
225                 230                 235                 240 


Leu Leu Ile Met Asp Arg Ala Ala Asp Pro Val Ser Pro Leu Leu His 
                245                 250                 255     


Glu Leu Thr Phe Gln Ala Met Ala Tyr Asp Leu Leu Asp Ile Glu Gln 
            260                 265                 270         


Asp Thr Tyr Arg Tyr Glu Thr Thr Gly Leu Ser Glu Ala Arg Glu Lys 
        275                 280                 285             


Ala Val Leu Leu Asp Glu Asp Asp Asp Leu Trp Val Glu Leu Arg His 
    290                 295                 300                 


Met His Ile Ala Asp Val Ser Lys Lys Val Thr Glu Leu Leu Arg Thr 
305                 310                 315                 320 


Phe Cys Glu Ser Lys Arg Leu Thr Thr Asp Lys Ala Asn Ile Lys Asp 
                325                 330                 335     


Leu Ser Gln Ile Leu Lys Lys Met Pro Gln Tyr Gln Lys Glu Leu Asn 
            340                 345                 350         


Lys Tyr Ser Thr His Leu His Leu Ala Asp Asp Cys Met Lys His Phe 
        355                 360                 365             


Lys Gly Ser Val Glu Lys Leu Cys Ser Val Glu Gln Asp Leu Ala Met 
    370                 375                 380                 


Gly Ser Asp Ala Glu Gly Glu Lys Ile Lys Asp Ser Met Lys Leu Ile 
385                 390                 395                 400 


Val Pro Val Leu Leu Asp Ala Ala Val Pro Ala Tyr Asp Lys Ile Arg 
                405                 410                 415     


Val Leu Leu Leu Tyr Ile Leu Leu Arg Asn Gly Val Ser Glu Glu Asn 
            420                 425                 430         


Leu Ala Lys Leu Ile Gln His Ala Asn Val Gln Ala His Ser Ser Leu 
        435                 440                 445             


Ile Arg Asn Leu Glu Gln Leu Gly Gly Thr Val Thr Asn Pro Gly Gly 
    450                 455                 460                 


Ser Gly Thr Ser Ser Arg Leu Glu Pro Arg Glu Arg Met Glu Pro Thr 
465                 470                 475                 480 


Tyr Gln Leu Ser Arg Trp Thr Pro Val Ile Lys Asp Val Met Glu Asp 
                485                 490                 495     


Ala Val Glu Asp Arg Leu Asp Arg Asn Leu Trp Pro Phe Val Ser Asp 
            500                 505                 510         


Pro Ala Pro Thr Ala Ser Ser Gln Ala Ala Val Ser Ala Arg Phe Gly 
        515                 520                 525             


His Trp His Lys Asn Lys Ala Gly Ile Glu Ala Arg Ala Gly Pro Arg 
    530                 535                 540                 


Leu Ile Val Tyr Val Met Gly Gly Val Ala Met Ser Glu Met Arg Ala 
545                 550                 555                 560 


Ala Tyr Glu Val Thr Arg Ala Thr Glu Gly Lys Trp Glu Val Leu Ile 
                565                 570                 575     


Gly Ser Ser His Ile Leu Thr Pro Thr Arg Phe Leu Asp Asp Leu Lys 
            580                 585                 590         


Ala Leu Asp Lys Lys Leu Glu Asp Ile Ala Leu Pro 
        595                 600                 


<210>  9
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  9
tggagtggga cagagaaatt aaca                                              24


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  10
gctggttttg cgattcttca a                                                 21


<210>  11
<211>  13
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  11
gccgccrcca ugg                                                          13


<210>  12
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  12
caccatggcg g                                                            11


<210>  13
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  13
cgccatggcg g                                                            11


<210>  14
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  14
cacgatggcg g                                                            11


<210>  15
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  15
caccatgacg g                                                            11


<210>  16
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  16
cgcgatggcg g                                                            11


<210>  17
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  17
cgccatgacg g                                                            11


<210>  18
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  18
cacgatgacg g                                                            11


<210>  19
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  19
cgcgatgacg g                                                            11


<210>  20
<211>  10
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  20
gccaccatgg                                                              10


<210>  21
<211>  1187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  21
atcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa       60

gttgggggga ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg      120

ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat      180

aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacaggt      240

aagtgccgtg tgtggttccc gcgggcctgg cctctttacg ggttatggcc cttgcgtgcc      300

ttgaattact tccacctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag      360

tgggtgggag agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga      420

ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct      480

cgctgctttc gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt      540

tttctggcaa gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt      600

tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg      660

cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct      720

ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc      780

ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa      840

atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc      900

ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca      960

cctcgattag ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta     1020

tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt     1080

gatgtaattc tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc     1140

tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgag                   1187


