                         SEQUENCE LISTING

<110>  CARIBOU BIOSCIENCES, INC.
       STENGEL, Katharina
 
<120>  SUICIDE MODULE COMPOSITIONS AND METHODS

<130>  CBI034.30

<150>  US 62/739,483
<151>  2018-10-01

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  184
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(184)
<223>  BCMA FL

<400>  1

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  2
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, BCMA TM

<400>  2

Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile Ile Ser Leu Ala Val 
1               5                   10                  15      


Phe Val Leu Met Phe Leu Leu 
            20              


<210>  3
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, BCMA ECD

<400>  3

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala 
    50                  


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, BCMA ICD

<400>  4

Arg Lys Ile Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly 
1               5                   10                  15      


Ser Gly Leu Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr 
            20                  25                  30          


Gly Asp Glu Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu 
        35                  40                  45              


Cys Thr Cys Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp 
    50                  55                  60                  


His Cys Phe Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val 
65                  70                  75                  80  


Thr Thr Lys Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser 
                85                  90                  95      


Ala Thr Glu Ile Glu Lys Ser Ile Ser Ala Arg 
            100                 105         


<210>  5
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, BCMA ICD truncated I

<400>  5

Arg Gly Ser Gly Leu Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser 
1               5                   10                  15      


Arg Thr Gly Asp Glu Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val 
            20                  25                  30          


Glu Glu Cys Thr Cys Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp 
        35                  40                  45              


Ser Asp His Cys Phe Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile 
    50                  55                  60                  


Leu Val Thr Thr Lys Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala 
65                  70                  75                  80  


Leu Ser Ala Thr Glu Ile Glu Lys Ser Ile Ser Ala Arg 
                85                  90              


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, BCMA ICD truncated II

<400>  6

Arg Lys Ile Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly 
1               5                   10                  15      


<210>  7
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, BCMA ECD N-terminal truncation

<400>  7

Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His Ala Cys 
1               5                   10                  15      


Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys 
            20                  25                  30          


Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys Gly Thr Asn 
        35                  40                  45              


Ala 
    


<210>  8
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, BCMA ECD C-terminal truncation

<400>  8

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys 
        35                  40      


<210>  9
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, BCMA ECD N- and C- terminal 
       truncation

<400>  9

Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His Ala Cys 
1               5                   10                  15      


Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys 
            20                  25                  30          


Gln Arg Tyr Cys 
        35      


<210>  10
<211>  235
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(235)
<223>  CD8 alpha

<400>  10

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  11
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, CD8 alpha signal sequence

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  12
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, CD8 alpha ECD

<400>  12

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        115                 120                 125             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    130                 135                 140                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
145                 150                 155                 160 


Asp 
    


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, CD8 alpha TM

<400>  13

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  14
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, CD8 alpha stalk

<400>  14

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: GSG linker

<400>  15

Gly Ser Gly 
1           


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: GGS linker

<400>  16

Gly Gly Ser 
1           


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (G3S) linker

<400>  17

Gly Gly Gly Ser 
1               


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (G4S) linker

<400>  18

Gly Gly Gly Gly Ser 
1               5   


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (G5S) linker

<400>  19

Gly Gly Gly Gly Gly Ser 
1               5       


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (G3S) linker

<400>  20

Gly Gly Gly Ser 
1               


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (GGS)7 linker

<400>  21

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser 
            20      


<210>  22
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: triple A linker

<400>  22

Ala Ala Ala 
1           


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (G3S)3

<400>  23

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (G4S)3

<400>  24

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (G4S)4

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (G4S)5

<400>  26

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: XTEN

<400>  27

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  28
<211>  119
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(119)
<223>  B2M

<400>  28

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, B2M signal sequence

<400>  29

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala 
            20  


<210>  30
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, B2M mature

<400>  30

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  31
<211>  358
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(358)
<223>  HLA-E

<400>  31

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Arg 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  32
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, HLA-E signal sequence

<400>  32

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala 
            20      


<210>  33
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, HLA-E mature

<400>  33

Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg 
        35                  40                  45              


Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met His Gly Cys Glu Leu Gly Pro Asp Arg Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu 
    130                 135                 140                 


Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys 
                165                 170                 175     


Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu 
            260                 265                 270         


Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile 
        275                 280                 285             


Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala 
    290                 295                 300                 


Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser 
                325                 330                 335     


Leu 
    


<210>  34
<211>  338
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(338)
<223>  HLA-G

<400>  34

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  35
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, HLA-G signal sequence


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  CD34

<400>  35

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala 
            20                  


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, HLA-G signal sequence short

<400>  36

Val Met Ala Pro Arg Thr Leu Phe Leu 
1               5                   


<210>  37
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Gly Glu Asp Pro Tyr Tyr Thr Glu Asn Gly Gly Gly 
                325                 330                 335     


Gln Gly Tyr Ser Ser Gly Pro Gly Thr Ser Pro Glu Ala Gln Gly Lys 
            340                 345                 350         


Ala Ser Val Asn Arg Gly Ala Gln Glu Asn Gly Thr Gly Gln Ala Thr 
        355                 360                 365             


Ser Arg Asn Gly His Ser Ala Arg Gln His Val Val Ala Asp Thr Glu 
    370                 375                 380                 


Leu 
385 


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, CD34 Q10 epitope

<400>  38

Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
1               5                   10                  15      


<210>  39
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD19 CAR

<400>  39

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
        275                 280                 285             


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
    290                 295                 300                 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  40
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, CAR signal sequence hGCMF

<400>  40

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  41
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD19 scFv

<400>  41

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser 
                


<210>  42
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CAR hinge

<400>  42

Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40          


<210>  43
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, CAR TM

<400>  43

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            20                  25              


<210>  44
<211>  19
<212>  PRT
<213>  Porcine teschovirus-1


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  P2A

<400>  44

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  45
<211>  18
<212>  PRT
<213>  Thosea asigna virus


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  T2A

<400>  45

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  46
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, BCMA ECD TM ICD truncated I

<400>  46

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Gly Ser 
65                  70                  75                  80  


Gly Leu Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly 
                85                  90                  95      


Asp Glu Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys 
            100                 105                 110         


Thr Cys Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His 
        115                 120                 125             


Cys Phe Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr 
    130                 135                 140                 


Thr Lys Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala 
145                 150                 155                 160 


Thr Glu Ile Glu Lys Ser Ile Ser Ala Arg 
                165                 170 


<210>  47
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H. sapiens partial, BCMA ECD TM ICD truncated II

<400>  47

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly 
                85                  90              


<210>  48
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA ECD CD8 TM

<400>  48

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    50                  55                  60                  


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
65                  70                  75                  80  


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                85                  90                  95      


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
            100                 105                 110         


Leu Leu Leu Ser Leu Val Ile Thr 
        115                 120 


<210>  49
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA ECD linker CD8TM

<400>  49

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg 
    50                  55                  60                  


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
65                  70                  75                  80  


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                85                  90                  95      


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            100                 105                 110         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        115                 120             


<210>  50
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA ECD CD34 CD8TM

<400>  50

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn 
    50                  55                  60                  


Val Ser Thr Asn Val Ser Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                85                  90      


<210>  51
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA ECD CD34 CD8 CD8TM

<400>  51

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn 
    50                  55                  60                  


Val Ser Thr Asn Val Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
65                  70                  75                  80  


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
                85                  90                  95      


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
            100                 105                 110         


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
        115                 120                 125             


Leu Leu Leu Ser Leu Val Ile Thr 
    130                 135     


<210>  52
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: scFv SM CAR signaling

<400>  52

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Met Leu Gln Met Ala 
            260                 265                 270         


Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His Ala Cys 
        275                 280                 285             


Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys 
    290                 295                 300                 


Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys Gly Thr Asn 
305                 310                 315                 320 


Ala Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn 
                325                 330                 335     


Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys 
            340                 345                 350         


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
        355                 360                 365             


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    370                 375                 380                 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
385                 390                 395                 400 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                405                 410                 415     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
            420                 425                 430         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        435                 440                 445             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    450                 455                 460                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
465                 470                 475                 480 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                485                 490                 495     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            500                 505                 510         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        515                 520                 525             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540             


<210>  53
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: SM scFv CAR signaling

<400>  53

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
    50                  55                  60                  


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
65                  70                  75                  80  


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
                85                  90                  95      


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
            100                 105                 110         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
        115                 120                 125             


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
    130                 135                 140                 


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
145                 150                 155                 160 


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
                165                 170                 175     


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
            180                 185                 190         


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
        195                 200                 205             


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
    210                 215                 220                 


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
225                 230                 235                 240 


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
                245                 250                 255     


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
            260                 265                 270         


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
        275                 280                 285             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Ile Glu 
    290                 295                 300                 


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
305                 310                 315                 320 


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
                325                 330                 335     


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
            340                 345                 350         


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
        355                 360                 365             


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    370                 375                 380                 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
385                 390                 395                 400 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    450                 455                 460                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
465                 470                 475                 480 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                485                 490                 495     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            500                 505                 510         


Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520     


<210>  54
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: scFvD1 SMS scFvD2 CAR signaling

<400>  54

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp 
    130                 135                 140                 


Ser Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn 
145                 150                 155                 160 


Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn 
                165                 170                 175     


Ser Val Lys Gly Thr Asn Ala Glu Val Lys Leu Gln Glu Ser Gly Pro 
            180                 185                 190         


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
        195                 200                 205             


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
    210                 215                 220                 


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
225                 230                 235                 240 


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
                245                 250                 255     


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            260                 265                 270         


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
        275                 280                 285             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala 
    290                 295                 300                 


Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
305                 310                 315                 320 


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
                325                 330                 335     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            340                 345                 350         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        355                 360                 365             


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
    370                 375                 380                 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
385                 390                 395                 400 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
                405                 410                 415     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            420                 425                 430         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        435                 440                 445             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    450                 455                 460                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
465                 470                 475                 480 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                485                 490                 495     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            500                 505                 510         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520                 525 


<210>  55
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: SS scFv SM CAR signaling

<400>  55

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
    50                  55                  60                  


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
65                  70                  75                  80  


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
                85                  90                  95      


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
            100                 105                 110         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
        115                 120                 125             


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
    130                 135                 140                 


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
145                 150                 155                 160 


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
                165                 170                 175     


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
            180                 185                 190         


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
        195                 200                 205             


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
    210                 215                 220                 


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
225                 230                 235                 240 


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
                245                 250                 255     


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
            260                 265                 270         


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
        275                 280                 285             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Met Leu Gln Met Ala 
    290                 295                 300                 


Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His Ala Cys 
305                 310                 315                 320 


Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys 
                325                 330                 335     


Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys Gly Thr Asn 
            340                 345                 350         


Ala Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn 
        355                 360                 365             


Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys 
    370                 375                 380                 


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
385                 390                 395                 400 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
                405                 410                 415     


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            420                 425                 430         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        435                 440                 445             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    450                 455                 460                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
465                 470                 475                 480 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                485                 490                 495     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            500                 505                 510         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        515                 520                 525             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    530                 535                 540                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
545                 550                 555                 560 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                565                 570                 575 


<210>  56
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CAR-T2A-BCMA suicide switch

<400>  56

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
        275                 280                 285             


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
    290                 295                 300                 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly 
                485                 490                 495     


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu 
            500                 505                 510         


Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu 
        515                 520                 525             


His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro 
    530                 535                 540                 


Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys 
545                 550                 555                 560 


Gly Thr Asn Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                565                 570                 575     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            580                 585                 590         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        595                 600                 605             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    610                 615                 620                 


Leu Ser Leu Val Ile Thr 
625                 630 


<210>  57
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HLA-G/B2M/HLA-E fusion

<400>  57

Val Met Ala Pro Arg Thr Leu Phe Leu Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg Ala 
            180                 185                 190         


Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr Arg 
        195                 200                 205             


Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr Leu 
    210                 215                 220                 


Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Trp 
225                 230                 235                 240 


Met His Gly Cys Glu Leu Gly Pro Asp Arg Arg Phe Leu Arg Gly Tyr 
                245                 250                 255     


Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu Gln 
        275                 280                 285             


Lys Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys Glu 
305                 310                 315                 320 


Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His Pro 
                325                 330                 335     


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His Thr 
        355                 360                 365             


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
385                 390                 395                 400 


Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu Arg 
                405                 410                 415     


Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala 
            420                 425                 430         


Gly Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala Ala 
        435                 440                 445             


Val Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr Ser 
    450                 455                 460                 


Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser Leu 
465                 470                 475                 480 


<210>  58
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: B2M/HLA-E fusion

<400>  58

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Leu Lys Tyr Phe His 
        115                 120                 125             


Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val 
    130                 135                 140                 


Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala 
145                 150                 155                 160 


Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser 
                165                 170                 175     


Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile 
            180                 185                 190         


Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
        195                 200                 205             


Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro 
    210                 215                 220                 


Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys 
225                 230                 235                 240 


Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp 
                245                 250                 255     


Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala 
            260                 265                 270         


Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His 
        275                 280                 285             


Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro 
    290                 295                 300                 


Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu 
305                 310                 315                 320 


Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp 
                325                 330                 335     


Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr 
            340                 345                 350         


Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val 
        355                 360                 365             


Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly 
    370                 375                 380                 


Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr 
385                 390                 395                 400 


Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val 
                405                 410                 415     


Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser 
            420                 425                 430         


Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala 
        435                 440                 445             


Gln Gly Ser Glu Ser His Ser Leu 
    450                 455     


<210>  59
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HLA-G/BCMA/B2M/HLA-E fusion

<400>  59

Val Met Ala Pro Arg Thr Leu Phe Leu Gly Ser Gly Met Leu Gln Met 
1               5                   10                  15      


Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His Ala 
            20                  25                  30          


Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr 
        35                  40                  45              


Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys Gly Thr 
    50                  55                  60                  


Asn Ala Gly Ser Gly Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser 
65                  70                  75                  80  


Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val 
                85                  90                  95      


Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly 
            100                 105                 110         


Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp 
        115                 120                 125             


Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys 
    130                 135                 140                 


Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys 
145                 150                 155                 160 


Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser 
            180                 185                 190         


Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro 
        195                 200                 205             


Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe 
    210                 215                 220                 


Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met 
225                 230                 235                 240 


Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg 
                245                 250                 255     


Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr 
            260                 265                 270         


Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly 
        275                 280                 285             


Cys Glu Leu Gly Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe 
    290                 295                 300                 


Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser 
305                 310                 315                 320 


Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn 
                325                 330                 335     


Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys 
            340                 345                 350         


Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu 
        355                 360                 365             


His Leu Glu Pro Pro Lys Thr His Val Thr His His Pro Ile Ser Asp 
    370                 375                 380                 


His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu 
385                 390                 395                 400 


Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr 
                405                 410                 415     


Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp 
            420                 425                 430         


Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His 
        435                 440                 445             


Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro 
    450                 455                 460                 


Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val 
465                 470                 475                 480 


Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp 
                485                 490                 495     


Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu 
            500                 505                 510         


Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser Leu 
        515                 520                 525 


<210>  60
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HLA-G/B2M/BCMA/HLA-E fusion

<400>  60

Val Met Ala Pro Arg Thr Leu Phe Leu Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Ser Gly Met Leu 
        115                 120                 125             


Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu 
    130                 135                 140                 


His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro 
145                 150                 155                 160 


Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys 
                165                 170                 175     


Gly Thr Asn Ala Gly Ser Gly Gly Ser His Ser Leu Lys Tyr Phe His 
            180                 185                 190         


Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val 
        195                 200                 205             


Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala 
    210                 215                 220                 


Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile 
                245                 250                 255     


Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
            260                 265                 270         


Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro 
        275                 280                 285             


Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys 
    290                 295                 300                 


Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp 
305                 310                 315                 320 


Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala 
                325                 330                 335     


Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His 
            340                 345                 350         


Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro 
        355                 360                 365             


Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu 
    370                 375                 380                 


Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp 
385                 390                 395                 400 


Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr 
                405                 410                 415     


Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val 
            420                 425                 430         


Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly 
        435                 440                 445             


Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr 
    450                 455                 460                 


Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val 
465                 470                 475                 480 


Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser 
                485                 490                 495     


Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala 
            500                 505                 510         


Gln Gly Ser Glu Ser His Ser Leu 
        515                 520 


<210>  61
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HLA-G/BCMA/B2M/BCMA/HLA-E fusion

<400>  61

Val Met Ala Pro Arg Thr Leu Phe Leu Met Leu Gln Met Ala Gly Gln 
1               5                   10                  15      


Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His Ala Cys Ile Pro 
            20                  25                  30          


Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg 
        35                  40                  45              


Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys Gly Thr Asn Ala Ile 
    50                  55                  60                  


Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn 
65                  70                  75                  80  


Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser 
                85                  90                  95      


Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val 
            100                 105                 110         


Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu 
        115                 120                 125             


Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg 
    130                 135                 140                 


Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg 
145                 150                 155                 160 


Asp Met Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe 
                165                 170                 175     


Asp Ser Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser 
            180                 185                 190         


Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr 
        195                 200                 205             


Asn Ser Val Lys Gly Thr Asn Ala Gly Ser His Ser Leu Lys Tyr Phe 
    210                 215                 220                 


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
225                 230                 235                 240 


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
                245                 250                 255     


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
            260                 265                 270         


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
        275                 280                 285             


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
    290                 295                 300                 


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
305                 310                 315                 320 


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
                325                 330                 335     


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
            340                 345                 350         


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
        355                 360                 365             


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
    370                 375                 380                 


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
385                 390                 395                 400 


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
                405                 410                 415     


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
            420                 425                 430         


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
        435                 440                 445             


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
    450                 455                 460                 


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
465                 470                 475                 480 


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
                485                 490                 495     


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
            500                 505                 510         


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
        515                 520                 525             


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
    530                 535                 540                 


Ala Gln Gly Ser Glu Ser His Ser Leu 
545                 550             


<210>  62
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BCMA/B2M/HLA-E fusion

<400>  62

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Gly Ser Gly Ile Gln Arg Thr Pro Lys Ile 
    50                  55                  60                  


Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu 
65                  70                  75                  80  


Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu 
                85                  90                  95      


Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser 
            100                 105                 110         


Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr 
        115                 120                 125             


Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu 
    130                 135                 140                 


Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
            180                 185                 190         


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
        195                 200                 205             


Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg 
    210                 215                 220                 


Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr 
225                 230                 235                 240 


Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr 
                245                 250                 255     


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
            260                 265                 270         


Trp Met His Gly Cys Glu Leu Gly Pro Asp Arg Arg Phe Leu Arg Gly 
        275                 280                 285             


Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu 
    290                 295                 300                 


Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu 
305                 310                 315                 320 


Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu 
                325                 330                 335     


Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys 
            340                 345                 350         


Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His 
        355                 360                 365             


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
    370                 375                 380                 


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His 
385                 390                 395                 400 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
                405                 410                 415     


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
            420                 425                 430         


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu 
        435                 440                 445             


Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile 
    450                 455                 460                 


Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala 
465                 470                 475                 480 


Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr 
                485                 490                 495     


Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser 
            500                 505                 510         


Leu 
    


<210>  63
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HLA-G/B2M/HLA-E 2A BCMA SM

<400>  63

Val Met Ala Pro Arg Thr Leu Phe Leu Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg Ala 
            180                 185                 190         


Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr Arg 
        195                 200                 205             


Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr Leu 
    210                 215                 220                 


Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Trp 
225                 230                 235                 240 


Met His Gly Cys Glu Leu Gly Pro Asp Arg Arg Phe Leu Arg Gly Tyr 
                245                 250                 255     


Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu Gln 
        275                 280                 285             


Lys Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys Glu 
305                 310                 315                 320 


Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His Pro 
                325                 330                 335     


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His Thr 
        355                 360                 365             


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
385                 390                 395                 400 


Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu Arg 
                405                 410                 415     


Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala 
            420                 425                 430         


Gly Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala Ala 
        435                 440                 445             


Val Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr Ser 
    450                 455                 460                 


Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser Leu 
465                 470                 475                 480 


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
                485                 490                 495     


Gly Pro Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe 
            500                 505                 510         


Asp Ser Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser 
        515                 520                 525             


Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr 
    530                 535                 540                 


Asn Ser Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu 
545                 550                 555                 560 


Ser Leu Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg 
                565                 570                 575     


Lys Ile Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser 
            580                 585                 590         


Gly Leu Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly 
        595                 600                 605             


Asp Glu Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys 
    610                 615                 620                 


Thr Cys Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His 
625                 630                 635                 640 


Cys Phe Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr 
                645                 650                 655     


Thr Lys Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala 
            660                 665                 670         


Thr Glu Ile Glu Lys Ser Ile Ser Ala Arg 
        675                 680         


<210>  64
<211>  220
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(220)
<223>  CD28

<400>  64

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  65
<211>  1502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: HLA-G/B2M/HLA-E fusion nucleotide sequence reverse

<400>  65
tacaagctgt gagactcaga cccctgggca ctgtcgctcc actcagcctt agagtagctc       60

cctccttttc cacctgagct cttcttcctc catatcacag cagcaaccac agctccagag      120

accacagatc caaggagaac caggccagca atgatgccca cgatggggat ggtgggctgg      180

gaagccggct tccatctcag ggtgacgggc tcgggtagcc cctcatgctg cacatggcac      240

gtgtatctct gctcctctcc agaaggcacc accacagctg cccacttctg gaaggttcca      300

tcccctgcag gcctggtctc cacgagctcc gtgtcctggg tatggccctc cccatcctgc      360

tgccaggtca gtgtgatctc cgcagggtag aagcccaggg cccagcacct cagggtggcc      420

tcatggtcag agatggggtg gtgagtcacg tgtgtctttg ggggctccag gtgaagcagc      480

gtctccttcc ccttctccag gtatttgtgg agccactcca cgcatgtgtc ttccaggtag      540

gctctctggt gctccgcctc agaagcatca tttgactttt gctcggagat ctgagccgcc      600

gtgtccaccg cggtccagga gcgcaggtcc tcattcaggg tgagataatc cttgccgtcg      660

taggcgaact gttcataccc gcggaggaag cgcccgtcgg gccccagctc gcagccatgc      720

atccactgca gggtgtgaga cccggcctcg ctctgattgt agtagccgcg cagcgtccgc      780

agattcactc ggaaaatctg tgcggtgtcc ctggcgctcc gtgtctcccg gtcccaatac      840

tctgacccct cctgctccat ccacggcgcc cgcggcacca tcctcggact cgcggcgtcg      900

ttgtcgaagc gcacgaactg ggtgtcgtcc acgtagccca cagagatgaa gcggggctcc      960

ccgcggccgg gccgggacac ggaagtgtgg aaatacttca aggagtggga tccagaccct     1020

ccgccaccag atccccctcc tccagaaccg cctccgccag accctccgcc acccatgtct     1080

cgatcccact taactatctt gggctgtgac aaagtcacat ggttcacacg gcaggcatac     1140

tcatcttttt cagtgggggt gaattcagtg tagtacaaga gatagaaaga ccagtccttg     1200

ctgaaagaca agtctgaatg ctccactttt tcaattctct ctccattctt cagtaagtca     1260

acttcaatgt cggatggatg aaacccagac acatagcaat tcaggaaatt tgactttcca     1320

ttctctgctg gatgacgtga gtaaacctga atctttggag tacgctggat ggagccgccg     1380

cctccgctac cgcctcctcc gctcccacct ccacccagaa agagggtccg tggtgccatt     1440

acagcctcca ggccagaaag agagagtagc gcgagcacag ctaaggccac ggagcgagac     1500

at                                                                    1502


<210>  66
<211>  500
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(500)
<223>  B2M left homology arm

<400>  66
ttcccaagct gtagttataa acagaagttc tccttctgct aggtagcatt caaagatctt       60

aatcttctgg gtttccgttt tctcgaatga aaaatgcagg tccgagcagt taactggctg      120

gggcaccatt agcaagtcac ttagcatctc tggggccagt ctgcaaagcg agggggcagc      180

cttaatgtgc ctccagcctg aagtcctaga atgagcgccc ggtgtcccaa gctggggcgc      240

gcaccccaga tcggagggcg ccgatgtaca gacagcaaac tcacccagtc tagtgcatgc      300

cttcttaaac atcacgagac tctaagaaaa ggaaactgaa aacgggaaag tccctctctc      360

taacctggca ctgcgtcgct ggcttggaga caggtgacgg tccctgcggg ccttgtcctg      420

attggctggg cacgcgttta atataagtgg aggcgtcgcg ctggcgggca ttcctgaagc      480

tgacagcatt cgggccgaga                                                  500


<210>  67
<211>  480
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(480)
<223>  B2M right homology arm

<400>  67
gctgtgctcg cgctactctc tctttctggc ctggaggcta tccagcgtga gtctctccta       60

ccctcccgct ctggtccttc ctctcccgct ctgcaccctc tgtggccctc gctgtgctct      120

ctcgctccgt gacttccctt ctccaagttc tccttggtgg cccgccgtgg ggctagtcca      180

gggctggatc tcggggaagc ggcggggtgg cctgggagtg gggaaggggg tgcgcacccg      240

ggacgcgcgc tacttgcccc tttcggcggg gagcagggga gacctttggc ctacggcgac      300

gggagggtcg ggacaaagtt tagggcgtcg ataagcgtca gagcgccgag gttgggggag      360

ggtttctctt ccgctctttc gcggggcctc tggctccccc agcgcagctg gagtggggga      420

cgggtaggct cgtcccaaag gcgcggcgct gaggtttgtg aacgcgtgga ggggcgcttg      480


