                         SEQUENCE LISTING

<110>  North Carolina State University
       Barrangou, Rodolphe
       Hidalgo-Cantabrana, Claudio
 
<120>  RECOMBINANT TYPE I CRISPR-CAS SYSTEM AND USES THEREOF FOR KILLING
        BACTERIAL AND ARCHAEON CELLS

<130>  5051-943WO

<150>  US 62/739,694
<151>  2018-10-01

<160>  195   

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  1
gtattctcca cgtgtgtgga ggtgatcc                                          28


<210>  2
<211>  27
<212>  DNA
<213>  Lactobacillus crispatus

<400>  2
gtattctcca cgtgtgtgga ggtgatc                                           27


<210>  3
<211>  26
<212>  DNA
<213>  Lactobacillus crispatus

<400>  3
gtattctcca cgtgtgtgga ggtgat                                            26


<210>  4
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  4
gtattctcca cgtgtgtgga ggtga                                             25


<210>  5
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  5
gtattctcca cgtgtgtgga ggtg                                              24


<210>  6
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  6
gtattctcca cgtgtgtgga ggt                                               23


<210>  7
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  7
gtattctcca cgtgtgtgga gg                                                22


<210>  8
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  8
gtattctcca cgtgtgtgga g                                                 21


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  9
gtattctcca cgtgtgtgga                                                   20


<210>  10
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  10
gtattctcca cacatgtgga ggtgatcc                                          28


<210>  11
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  11
gtattctcca cacatgtgga ggtgatc                                           27


<210>  12
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  12
gtattctcca cacatgtgga ggtgat                                            26


<210>  13
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  13
gtattctcca cacatgtgga ggtga                                             25


<210>  14
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  14
gtattctcca cacatgtgga ggtg                                              24


<210>  15
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  15
gtattctcca cacatgtgga ggt                                               23


<210>  16
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  16
gtattctcca cacatgtgga gg                                                22


<210>  17
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  17
gtattctcca cacatgtgga g                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  18
gtattctcca cacatgtgga                                                   20


<210>  19
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  19
gtattctcca cgcatgtgga ggtgatcc                                          28


<210>  20
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  20
gtattctcca cgcatgtgga ggtgatc                                           27


<210>  21
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  21
gtattctcca cgcatgtgga ggtgat                                            26


<210>  22
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  22
gtattctcca cgcatgtgga ggtga                                             25


<210>  23
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  23
gtattctcca cgcatgtgga ggtg                                              24


<210>  24
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  24
gtattctcca cgcatgtgga ggt                                               23


<210>  25
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  25
gtattctcca cgcatgtgga gg                                                22


<210>  26
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  26
gtattctcca cgcatgtgga g                                                 21


<210>  27
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  27
gtattctcca cgcatgtgga                                                   20


<210>  28
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  28
gtattctcca cgtatgtgga ggtgatcc                                          28


<210>  29
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  29
gtattctcca cgtatgtgga ggtgatc                                           27


<210>  30
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  30
gtattctcca cgtatgtgga ggtgat                                            26


<210>  31
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  31
gtattctcca cgtatgtgga ggtga                                             25


<210>  32
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  32
gtattctcca cgtatgtgga ggtg                                              24


<210>  33
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  33
gtattctcca cgtatgtgga ggt                                               23


<210>  34
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  34
gtattctcca cgtatgtgga gg                                                22


<210>  35
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  35
gtattctcca cgtatgtgga g                                                 21


<210>  36
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  36
gtattctcca cgtatgtgga                                                   20


<210>  37
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  37
gtattctcca cgtatgtgga ggtcatcc                                          28


<210>  38
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  38
gtattctcca cgtatgtgga ggtcatc                                           27


<210>  39
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  39
gtattctcca cgtatgtgga ggtcat                                            26


<210>  40
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  40
gtattctcca cgtatgtgga ggtca                                             25


<210>  41
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  41
gtattctcca cgtatgtgga ggtc                                              24


<210>  42
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  42
gtattctcca cgagtgtggg gatcctat                                          28


<210>  43
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  43
gtattctcca cgagtgtggg gatccta                                           27


<210>  44
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  44
gtattctcca cgagtgtggg gatcct                                            26


<210>  45
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  45
gtattctcca cgagtgtggg gatcc                                             25


<210>  46
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  46
gtattctcca cgagtgtggg gatc                                              24


<210>  47
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  47
gtattctcca cgagtgtggg gat                                               23


<210>  48
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  48
gtattctcca cgagtgtggg ga                                                22


<210>  49
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  49
gtattctcca cgagtgtggg g                                                 21


<210>  50
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  50
gtattctcca cgagtgtggg                                                   20


<210>  51
<211>  29
<212>  DNA
<213>  Lactobacillus crispatus

<400>  51
gtattctcca cgtatgtgga ggtgatccc                                         29


<210>  52
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  52
gtattctcca cgtatgtgga ggtgatcc                                          28


<210>  53
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  53
gtattctcca cgtatgtgga ggtgatc                                           27


<210>  54
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  54
gtattctcca cgtatgtgga ggtgat                                            26


<210>  55
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  55
gtattctcca cgtatgtgga ggtga                                             25


<210>  56
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  56
gtattctcca cgtatgtgga ggtg                                              24


<210>  57
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  57
gtattctcca cgtatgtgga ggt                                               23


<210>  58
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  58
gtattctcca cgtatgtgga gg                                                22


<210>  59
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  59
gtattctcca cgtatgtgga g                                                 21


<210>  60
<211>  29
<212>  DNA
<213>  Lactobacillus crispatus

<400>  60
gtattctcca cgtgtgtgga ggtgatcct                                         29


<210>  61
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  61
gtattctcca cgtgtgtgga ggtgatcc                                          28


<210>  62
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  62
gtattctcca cgtgtgtgga ggtgatc                                           27


<210>  63
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  63
gtattctcca cgtgtgtgga ggtgat                                            26


<210>  64
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  64
gtattctcca cgtgtgtgga ggtga                                             25


<210>  65
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  65
gtattctcca cgtgtgtgga ggtg                                              24


<210>  66
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  66
gtattctcca cgtgtgtgga ggt                                               23


<210>  67
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  67
gtattctcca cgtgtgtgga gg                                                22


<210>  68
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  repeat sequence

<400>  68
gtattctcca cgtgtgtgga g                                                 21


<210>  69
<211>  200
<212>  DNA
<213>  Lactobacillus crispatus

<400>  69
acaaaaaaga actttagttg aattactgtt gtataagcgt tgtcgaaaga tgacgtcttt       60

tttgtatgtt tagggagaca agaaaattct attcgttgga tgactaatga gacagaaata      120

gatacaatag taattgacaa agtgatgaaa ttttgggatc tattgttttg tgattgttgt      180

tatattggga tttgtttact                                                  200


<210>  70
<211>  200
<212>  DNA
<213>  Lactobacillus crispatus

<400>  70
cttgatatat aaggatttat aaatgaaatt tgaatcctag gggcactttg ggagcaaaac       60

tattcaaaaa gaagcagaaa tgcttctttt ttatttggag tggctttttg taattatggc      120

tttattattg gtctttgtta aaagtgatta aaaatgatat tatttcgatt gagcgatgct      180

gatatattgt ggatcattta                                                  200


<210>  71
<211>  200
<212>  DNA
<213>  Lactobacillus crispatus

<400>  71
gcagacaaat aatatttttc tttatttgtt taggaggaat catagcagaa tgatattatg       60

attcctcttt ttatttgaat attatgtcta gcagatattg tctatttaat aaaaatcgat      120

atacttggta gtaggatcaa agtgatgaaa aaatggtgtt tgcgtatttt catttggcgc      180

tataaaggga tttgtttact                                                  200


<210>  72
<211>  201
<212>  DNA
<213>  Lactobacillus crispatus

<400>  72
atattcccaa accaatccag caccacttga tggttcatct aagggcggaa aatgggaaga       60

ttttagcatt tgggattatg ataaatatga tcaagtaata aaagacatcg attatcctat      120

gtatataaat aaaaatagat tgtaaaataa aaagtaatta taaatattag attaagcaga      180

tagtataaat ttaggagaaa c                                                201


<210>  73
<211>  212
<212>  DNA
<213>  Lactobacillus crispatus

<400>  73
taaactgtat taagtgtatt cctcacttag gtgagggtga tcctgttaat tatttattta       60

ttgaagtaat ccccatcaaa gtggggttta gcggtttcag tatatgaaac cgctttttat      120

tttattgaaa aagtattgta aataaaataa ataagcttta atataaatat gaatgttaaa      180

tatttattta atgaggaaag aaacggtgat at                                    212


<210>  74
<211>  189
<212>  DNA
<213>  Lactobacillus crispatus

<400>  74
aaaataagta aaaaaggttt acattttcaa actatttagt ataattagca aaggatattt       60

tcgttaggca atttcgctta agctttttta ctaggcattt gccgaagaaa gtagtacaat      120

attcaacaga gaattatccg ttaacttatc tcaacggact tcttgcaaat ttacaggagg      180

gtcatttta                                                              189


<210>  75
<211>  214
<212>  DNA
<213>  Lactobacillus crispatus

<400>  75
tttagattcc ttattttttg tatttatttt aatacatata ttatagtcct ttgatataga       60

gttttttagg ctgctttact aatttttaaa atgtaaaccg ctttcatatg tttacaccgt      120

cacaaagtta ggctaaaatt tgagatgtaa agcggagcaa aaattgttcc gtatggtatg      180

aaaaacatac cataattttt gaggaggttt atta                                  214


<210>  76
<211>  451
<212>  DNA
<213>  Lactobacillus acidophilus

<400>  76
atcttaagga attagctaat gaagcttgtt ttgtttcaga aactgctgaa gaaaacgaaa       60

aattagttaa cgacttaatg aagaaaatta acaagtaatt ttcaaaaaga gaccatctgg      120

tctctttttt tatattttta agtaaaacaa ataatttctt cacaaataat tcacgcttta      180

tttttagaat ataagtagtt gtaagtataa aagataaaat gagtacttac aaaaaagaag      240

ttagtatgtt atactgatta taagttaaag aacgtataca aatatttgtt ctgaggagcg      300

tgatttttat ggtagattta tatgtctctc ctagttgtac ctcatgtcgt aaggcaagag      360

catggcttga aaaacataat attccattta aggaaagaaa cattttttct gagccattaa      420

ctaaagaaga attattaaag atcctctaga g                                     451


<210>  77
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  rho independent terminator

<400>  77
aaaaaaaaac cccgcccctg acagggcggg gtttttttt                              39


<210>  78
<211>  39
<212>  DNA
<213>  Lactobacillus crispatus

<400>  78
caaaaaaagc atgagaatta attttctcat gcttttttg                              39


<210>  79
<211>  38
<212>  DNA
<213>  Lactobacillus crispatus

<400>  79
aaaaaagatg cacttcttca caggagcgca tctttttt                               38


<210>  80
<211>  32
<212>  DNA
<213>  Lactobacillus crispatus

<400>  80
caaaaagagc ggctataggc cgcttttttt gc                                     32


<210>  81
<211>  37
<212>  DNA
<213>  Lactobacillus crispatus

<400>  81
gtaaaaatgg cttgcgtgtt gcaagccatt tttttac                                37


<210>  82
<211>  1730
<212>  DNA
<213>  Lactobacillus crispatus

<400>  82
atgaataatg atttaagctt caatctggtt actgatcctt ggattaaagt cctgaaaaag       60

gattataccg aaagtgaggt ctctttgaat gaacttttta gtaattctga agagtatctt      120

cagcttgctg gtgatatgaa atcacaagac ttagcgattc tcagattatt gttggctatt      180

ttactgtcag tttatactag attcgatgca gatgatacgc catactcatg gctggattta      240

gatgacaaat ggcgagtgac tcggacagat aatgatggct tcaactctca aaaactaaaa      300

ctgggagaca cttggagaag tctatatgat caaaaaactt tttcaaaaaa agtatttgat      360

tatctaaatc tttatcaggc taagtttaat ttatttggtg aagatccttt ttatcaagtt      420

aatcgtcaag tctatgacca aaatgtgccg gaaaataaaa aggtagctaa aggtgcgggt      480

acagtatcag ttaaacaaat taatcgactt atttctgaaa gcaataacag cccggcactg      540

ttttcaccta aatcaggtat tgaaaaagat agtgttaata atgcggaatt agttcgctgg      600

ttaattactt accaaaactt cacaggtgtt actgataaga ccaaagttaa gtcaaaggat      660

aagttctctg tttctcctgg ttggttgtat tcaattaatc ctgtttatat taaaggtaaa      720

actttatttg acacgttgat gttaaatcta agcttagtta ccaatgattc tgcagatgga      780

acaaactggc taaactcaca aagaccagtg tgggaatacg atgatattaa tgattatctt      840

caacaaagat tgaatggagt gtatcctgac aatttgtctg aattatatac tgtctggtct      900

agaatgattc atattgattg gcaaaatggt cagccagtta tatttagcgc aggactgcct      960

aagttagata gtgaaaaaca attcctagag ccaatgacga cttggcgtaa aaataaagat     1020

ggtgttgtat atccagctgc caagaataaa aataatataa atgtcgctat gtggcgtaat     1080

tttggtcagt atataaggac taaagaagat aataacaacg aaaaaaagat aaaaataatc     1140

acagaattcc aggagttatt ggttggattc aggaattgaa aatgcataat caaatttcca     1200

agcatactaa catcaatata gttacagtag ctatgataag tgatggaaat gctacatctc     1260

aatcacctta tgcggaaatc actgataata tgcaagctaa ggcagggatc ctttttgatg     1320

atgagcctat gtttgaaaat cggtggcaag ataagattga agaagaagta ttattagcac     1380

aaaaggttgt ggcttatttc tattggtttg caaaagatat atcgaacatt caaacccata     1440

gcgagaagaa aaaaagtaat gatgattggg caagtcgaaa ggtagcgcaa ctttatgacg     1500

aactgaatca gccattttac acttggcttt ctggattaga tataaatcaa gaccgtaatg     1560

tcaaaattaa agaatggcgt gaaactttaa atcgtcttgt tgcaacgcaa gctaaaaata     1620

tttttatcaa tgcaactgct gatgaaatca ttggcgggaa ggaagacaat atttttacaa     1680

tttataataa actacgcaga aacgtctatg tttgtctcgg attaaaataa                1730


<210>  83
<211>  606
<212>  DNA
<213>  Lactobacillus crispatus

<400>  83
atgagtgatg cttatactgc tacggcacga ataattaatc agctgtatgg tgatggaact       60

cctgataaag gtgctttggc tgaacttaga aggacaacag ctatcaccga taaaggcgct      120

gaaaaaatct ggcctttaat tttttcagtc gtgcctaaat taagtacaaa tggaaagcct      180

acaaagcttg aaacagcagt ttatactgct cttcactgtt atgctgcatt tcaacaaggg      240

aatgattcat ttgtctttgg tcaaattcct agatcaaaag ataaggaaga atctggagaa      300

aatggtgtat ctctttttac tgcactgagg aaaatgaaaa taaacgactc taacgaaaag      360

aaggctttag ataggcgagt aacagcttta ttagcaacta caaatatcag cagtgccacc      420

aattcaatta atcatctagt aagtattctt aaaggaaaga aaatgggtga aaagattgac      480

tttgctcaat tggcggaaga cttgtataac tttcagtgga gtacgaaaaa tgcaagattc      540

gttgccttga agtggggaaa agattactac tggaacgttt ataagctggc atcagacaac      600

gattag                                                                 606


<210>  84
<211>  1110
<212>  DNA
<213>  Lactobacillus crispatus

<400>  84
atgaataaga atctttatat ggacattaat gtattgcaaa ctgtaccatc atcaaatatc       60

aatagagatg acactggttc acctaaaaca gctatttatg gtggcgtgac tcggtcaaga      120

gtttcttcac aaagctggaa gagagcaatg cgtttagcct ttaaacaaga ctcagaaaat      180

gaagagtggc ttaagagcta tagaactttg aaaacagcta gtcttttggc gaataagtta      240

caagaactag attcaaattt aagtgaagaa gatgctttaa agaaagttga agaagtcttt      300

aaagtagctg gaatcaaatt aaaaaaggac aagaaaacgg gcgaaatgtt aactggagca      360

ctactactag taagtgaagg gcaactcgaa aagatcgcta aacttgcttt gtctgttgat      420

caaatagata aagatacagc taaagaaatt aagaaaaatt tgatggaaga tcaatctcta      480

gatttagctt tatttggaag aatggtggca gataatccag aattgaatgt ggatgcttct      540

agtcaagtgg ctcatgcaat ttccactcat gaagttactc cagaatttga ttattacact      600

gcagttgatg atgcaaatac gaaaagccaa acaggttctg caatgcttgg tacgattgaa      660

tataattcat ctactttata cagatatgcc aatgttaaca ttcttgattt attgcacaat      720

cttggtaata aagatttgac tattgaggga attaagcttt ttatcaaaga atttgttttg      780

acaatgccga ctggtaagga aaatactttt gctaataaaa cactccctca atacgttatg      840

attaatgttc gtactgatac acctgttaac ctagtatctg catttgaaac accagttaga      900

tctgaaggcg gatacgttga taaatctatc aatcgattag aggatgaata taaaaattct      960

ttgaaatttg tagataagcc tgtgtttaat gtcgaattga cgaatagtga gaatatagtc     1020

gacaatcagg ctgaaaatat tgatgattta attaatcaaa ctgctgaatt cgtaaaacag     1080

gagttagaaa atgaagacag caacgattag                                      1110


<210>  85
<211>  726
<212>  DNA
<213>  Lactobacillus crispatus

<400>  85
atgaagacag caacgattag attgactgcg ccacttcagt cttatggcaa tcccgcatct       60

tttaaccaaa gaactagtga tagttatcca actaaaagcg ctattgtagg tatgattgca      120

gctgcattgg gctacgcaag agaagataat gaaaaaactt tggagctaaa taatttatta      180

tttgctgttc gaattgagca atcaggcaaa atgttgacag agtttcaaac agtggaatac      240

agaaagagtg caagcaagac tgctcgaaag ttaacgtatc gtgattttat tcaagatgga      300

gttttcatgg tagcaattgg cagcgatgat gatcaattga tcgaaaacat caaagaagca      360

cttgaacatc caaaatttca gctttattta ggaagacggt ctaatccgcc agctggtcca      420

cttaaaattg atatttttaa tggaagaaat cccttacaag tactagaaga tttgccttgg      480

caagcttcag attggtataa gaggagcttt aagacgtcac aatttctaac tagaataatt      540

gctgatgcta gtttagattc tgaaagtacc cccttaatga aaaaagataa agtgggctct      600

tttgatcaaa aagatagata ttatcaatat cgtcctgtcg taatcaaaaa agcagttaaa      660

cttaaaaatt cagaaaataa tcagacagca gataatactg attgggattt ttggtcattt      720

gtgtag                                                                 726


<210>  86
<211>  657
<212>  DNA
<213>  Lactobacillus crispatus

<400>  86
atgtatattt cgagagttga aattgatact aacaaccgac aaaaaattag ggatttgtat       60

catttaggtg cttatcataa ttgggttgaa aattgctttc cagatgaatt aaagaaaaaa      120

gtaagattac gccatttatg gagaattgat gaattaaatg gtaaaaagta tttacttgtt      180

ttaagtgaag aaaagccaaa attagataag cttgaaagat atggtcttgc caatacggca      240

gagacgaaag actatgatca ttttttaagt agtttaaatc aaggaaaaaa atatcgcttt      300

aaactaacgg ctaatccttc atatagaatt acagatgcaa aaaccggtaa atcaaaagta      360

gtaccgcata ttactgtttt gcagcaaact aagtggttat tagatcgatc agaaaaatat      420

ggttttgatt tagttaaatc agaagatgac gaagaaacat atgaaatgaa tattacgtca      480

agagattggc cacgattacg ccgcaagggc aataaaatag taaaattaag tcgtgttact      540

tttgaaggct tattagagat taaggatttg caacaattta agcaggcaat ggtaactggt      600

atagggcgtg aaaaagcttt tgggatggga ctactcactg taattccaat ggaataa         657


<210>  87
<211>  2751
<212>  DNA
<213>  Lactobacillus crispatus

<400>  87
atgacaaatt tatcaaatac caccctgtct ttatggggta aaaagaatat taatgaagat       60

agcgaagaag tatggttacc cttaatcgct cacttaattg acacaaaaaa tgttattgga      120

tggttatata atcattggct taatgacggc caaagatgca ttttgagtca gggttttgaa      180

aactcaaatg aagttcagaa tcttgttgaa tttattggat acattcatga tattggtaag      240

gctacgcctg cttttcaaat taagcaatcg tttatccata atgaagattt agaccaggat      300

ctgttagaga gattattaca aaatggattt gataatttag aagaattaaa ggcaaatatg      360

gatactagac actggctcca cgctctggct ggtgaagtga tcttagaaaa tagtgggcta      420

aatgaaagta ttggcgctat agttggcggg caccatggta aaccacaaaa taagtatttt      480

gactatgaag atcaactgat ggatgatact tctaaatatt atcaatcaga ttcttgggcc      540

gaaaatccaa ctagagaaaa atgggaaaat gtacaaaaag agatcatcaa ttatggttta      600

gatttgtgta attttaaaaa tttagaagat atacctacag ttactgactc acaagcagta      660

attttagaag gcctagtcat tatggccgac tggttggcat ctagtgaata tacaattaaa      720

gatggtaagc gtgttagcat gtttccatta atctcgatgg atcaaggttt tagcgatatt      780

gatatgacat caagatatca acaaggaatt ttaaattggc ttaaaacaga ttcctggacg      840

cctcaattga tagtcgatac taaagagcaa tatcaaaaac gctggaattt tgatccaaga      900

caagttcagg aacaaatgtc tcaagcaatc ggagatagtg tggatcctag catgattatc      960

gttgaagccc cgatgggtat tggtaaaact gaaatagctt taaccgctgt tgagcaatta     1020

gctgctaaga ccggtatcaa tggcctgttt tttggcttgc caactcaggc tactgcaaat     1080

gcaatgtttg atagagtaga taactggctg gggaatattg ccaaagaaca gagcgaaaat     1140

ctttctatta aattgatgca tggaaaggca cagtttaatc aaaaatatca caatattcct     1200

gatgctgatg atattgaaac cgatgaaggt gcagttgttg ttaatcagtg gtttaatggt     1260

aaaaagtcaa tattaactga ctttgtaatt ggaactattg atcaattgct tttgatgggc     1320

ttgaagcaaa agcatctggc cttaagacat ttagggctaa gcggaaaaat agttgtaatt     1380

gacgaggttc atgcttatga cgtatatatg agttcctatc ttgaaaaggc aatagagtgg     1440

ttgggggcat atcatgtacc agttgttgct ttgtcggcta cgcttccagt tgataaaaga     1500

aatgaacttc ttacagcata ttgtagagga aaatatggca gtgaaaaatt taaagctcaa     1560

aatactaatt ggcaaacttg tcaagcatat cccttattaa gtattttgga tggcaaagtt     1620

ttaaaacaaa agtcagactt ttctactaaa gctgatgata ctacagttaa agttactcgc     1680

ttaagcattg aaaattacga tttaattgaa aagattaatg atcaaattga agatggcggt     1740

gtcgcaggtg tcatagttaa tacggtaaag cgagcacaag aattggcaaa aattgctgaa     1800

aaagagtgct ctgaagatac gcaaattttg gtgcttcatt ccgcattttt ggctaatgat     1860

cgtagtaatt tagagtccaa attggaaaag tcaattggaa atcaccaaaa acgtccaaag     1920

aaaatgatag taattggcac gcaagtgctc gaacaatctt tggatatcga ttttgatgtt     1980

atgtatacgg atattgcacc aatagacttg attttacaaa gagcgggtcg tttgcatcgt     2040

catcaagtta agcgcccaga caaattaatt gagcctcaac tattcattat gggtattaat     2100

tctaatgggg actatgggga tgcaaatcaa gcaatatatg agaaatatct tttaattaag     2160

acggatcatt tcttaaaaga caatatcaaa ttacctagtg atatttctaa tttggttcaa     2220

aaggtatatt cagcggatac tgataatgaa gtacaagatc ttcaggaagc ggaagttaag     2280

aaattcaaca ttgatcagga aaaggcagaa caaaaatcga aagggtatca aattagagcc     2340

ccaagagttg aaaaaacttt acacggttgg cttgataatg atagtgacac tgatctaaat     2400

gatgttaaag cagaggctgc tgtcagagat acgaatgaaa caatcgaggt tcttttgcta     2460

aaaaaagatg ccgatggatt ttatttaatg gatgggcgaa aagtggatga agaagttcct     2520

gatagcgttg ttgctcagca gttgattagg ctgccccatg cattaacgat ggatataaac     2580

caatctatac gaaatttgga acgagatact attagtaatt ttcctgaatg gcagaacagt     2640

tcctggttaa agggctcggt agctttaatt cttgatgcca ataatgagac agaatttaat     2700

ggatataaaa ttaagtattc atctgacttg gggttatcgt acgaaaaata g              2751


<210>  88
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  88
atgctaatgg agaaactaca agttaatccg gcaaagctaa atggccggcc cgt              53


<210>  89
<211>  89
<212>  DNA
<213>  Artificial

<220>
<223>  Pre-crRNA

<400>  89
gtattctcca cgtgtgtgga ggtgatccta acaatatgac cgctactgaa ttgttgaagc       60

agtattctcc acgtgtgtgg aggtgatcc                                         89


<210>  90
<211>  61
<212>  DNA
<213>  Artificial

<220>
<223>  Mature crRNA

<400>  90
gtgatcctaa caatatgacc gctactgaat tgttgaagca gtattctcca cgtgtgtgga       60

g                                                                       61


<210>  91
<211>  61
<212>  RNA
<213>  Artificial

<220>
<223>  crRNA boundary

<400>  91
gugauccuaa caauaugacc gcuacugaau uguugaagca guauucucca cgugugugga       60

g                                                                       61


<210>  92
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  92
cagtttaggt accatttttt gacgatcaaa atc                                    33


<210>  93
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  93
aaacagttta ggtaccattt tttgacgatc aaaatc                                 36


<210>  94
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  94
cagttcaaat gttacttggc cacgcaaata taa                                    33


<210>  95
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  95
aaacagttca aatgttactt ggccacgcaa atataa                                 36


<210>  96
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  96
cgtgttgttt ccatattcat tagataaaac atc                                    33


<210>  97
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  97
aaacgtgttg tttccatatt cattagataa aacatc                                 36


<210>  98
<211>  116
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  98
ttactgtatt ctccacgtgt gtggaggtga tcctgagacc aaaggtctcg tattctccac       60

gtgtgtggag gtgatccaaa aaaaaacccc gcccctgaca gggcggggtt tttttt          116


<210>  99
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  sequence

<400>  99
ttactgtatt ctccacgtgt gtggaggtg                                         29


<210>  100
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  sequence

<400>  100
tattctccac gtgtgtggag gtgatccaaa aaaaaacccc gcccctgaca gggcggggtt       60

tttttt                                                                  66


<210>  101
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  sequence

<400>  101
atgacataag aggtgcacac acctccacta gg                                     32


<210>  102
<211>  62
<212>  DNA
<213>  Artificial

<220>
<223>  sequence

<400>  102
gaggtgcaca cacctccact aggttttttt ttggggcggg gactgtcccg ccccaaaaaa       60

aa                                                                      62


<210>  103
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Annealing oligonucleotide

<400>  103
atccctacaa gttaatccgg caaagctaaa tggccggg                               38


<210>  104
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Annealing oligonucleotide

<400>  104
gatgttcaat taggccgttt cgatttaccg gcccataa                               38


<210>  105
<211>  36
<212>  DNA
<213>  Lactobacillus crispatus

<400>  105
aaactacaag ttaatccggc aaagctaaat ggccgg                                 36


<210>  106
<211>  133
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  106
ttactgtatt ctccacgtgt gtggaggtga tccctacaag ttaatccggc aaagctaaat       60

ggccgggtat tctccacgtg tgtggaggtg atccaaaaaa aaaccccgcc cctgacaggg      120

cggggttttt ttt                                                         133


<210>  107
<211>  61
<212>  RNA
<213>  Artificial

<220>
<223>  crRNA

<400>  107
gugaucccua caaguuaauc cggcaaagcu aaauggccgg guauucucca cgugugugga       60

g                                                                       61


<210>  108
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  108
tacgattacc tctttgatgt tcaattaggc cgtttcgatt taccggccgg gcat             54


<210>  109
<211>  102
<212>  DNA
<213>  Lactobacillus crispatus

<400>  109
agtaattagg agagtaagag gcaatgatgc taatggagaa actacaagtt aatccggcaa       60

agctaaatgg ccggcccgta tatcatacag ttaagcgagt at                         102


<210>  110
<211>  78
<212>  DNA
<213>  Lactobacillus crispatus

<400>  110
agtaattagg agagtaagag gcaatgatgc taatggagaa ataatagtga cccgtatatc       60

atacagttaa gcgagtat                                                     78


<210>  111
<211>  102
<212>  DNA
<213>  Lactobacillus crispatus

<400>  111
agtaattagg agagtaagag gcaatgatgc taatggagag actacaagtt aatccggcaa       60

agctaaatgg ccggcccgta tatcatacag ttaagcgagt at                         102


<210>  112
<211>  392
<212>  PRT
<213>  Lactobacillus crispatus

<400>  112

Met Asn Asn Asp Leu Ser Phe Asn Leu Val Thr Asp Pro Trp Ile Lys 
1               5                   10                  15      


Val Leu Lys Lys Asp Tyr Thr Glu Ser Glu Val Ser Leu Asn Glu Leu 
            20                  25                  30          


Phe Ser Asn Ser Glu Glu Tyr Leu Gln Leu Ala Gly Asp Met Lys Ser 
        35                  40                  45              


Gln Asp Leu Ala Ile Leu Arg Leu Leu Leu Ala Ile Leu Leu Ser Val 
    50                  55                  60                  


Tyr Thr Arg Phe Asp Ala Asp Asp Thr Pro Tyr Ser Trp Leu Asp Leu 
65                  70                  75                  80  


Asp Asp Lys Trp Arg Val Thr Arg Thr Asp Asn Asp Gly Phe Asn Ser 
                85                  90                  95      


Gln Lys Leu Lys Leu Gly Asp Thr Trp Arg Ser Leu Tyr Asp Gln Lys 
            100                 105                 110         


Thr Phe Ser Lys Lys Val Phe Asp Tyr Leu Asn Leu Tyr Gln Ala Lys 
        115                 120                 125             


Phe Asn Leu Phe Gly Glu Asp Pro Phe Tyr Gln Val Asn Arg Gln Val 
    130                 135                 140                 


Tyr Asp Gln Asn Val Pro Glu Asn Lys Lys Val Ala Lys Gly Ala Gly 
145                 150                 155                 160 


Thr Val Ser Val Lys Gln Ile Asn Arg Leu Ile Ser Glu Ser Asn Asn 
                165                 170                 175     


Ser Pro Ala Leu Phe Ser Pro Lys Ser Gly Ile Glu Lys Asp Ser Val 
            180                 185                 190         


Asn Asn Ala Glu Leu Val Arg Trp Leu Ile Thr Tyr Gln Asn Phe Thr 
        195                 200                 205             


Gly Val Thr Asp Lys Thr Lys Val Lys Ser Lys Asp Lys Phe Ser Val 
    210                 215                 220                 


Ser Pro Gly Trp Leu Tyr Ser Ile Asn Pro Val Tyr Ile Lys Gly Lys 
225                 230                 235                 240 


Thr Leu Phe Asp Thr Leu Met Leu Asn Leu Ser Leu Val Thr Asn Asp 
                245                 250                 255     


Ser Ala Asp Gly Thr Asn Trp Leu Asn Ser Gln Arg Pro Val Trp Glu 
            260                 265                 270         


Tyr Asp Asp Ile Asn Asp Tyr Leu Gln Gln Arg Leu Asn Gly Val Tyr 
        275                 280                 285             


Pro Asp Asn Leu Ser Glu Leu Tyr Thr Val Trp Ser Arg Met Ile His 
    290                 295                 300                 


Ile Asp Trp Gln Asn Gly Gln Pro Val Ile Phe Ser Ala Gly Leu Pro 
305                 310                 315                 320 


Lys Leu Asp Ser Glu Lys Gln Phe Leu Glu Pro Met Thr Thr Trp Arg 
                325                 330                 335     


Lys Asn Lys Asp Gly Val Val Tyr Pro Ala Ala Lys Asn Lys Asn Asn 
            340                 345                 350         


Ile Asn Val Ala Met Trp Arg Asn Phe Gly Gln Tyr Ile Arg Thr Lys 
        355                 360                 365             


Glu Asp Asn Asn Asn Glu Lys Lys Ile Lys Ile Ile Thr Glu Phe Gln 
    370                 375                 380                 


Glu Leu Leu Val Gly Phe Arg Asn 
385                 390         


<210>  113
<211>  201
<212>  PRT
<213>  Lactobacillus crispatus

<400>  113

Met Ser Asp Ala Tyr Thr Ala Thr Ala Arg Ile Ile Asn Gln Leu Tyr 
1               5                   10                  15      


Gly Asp Gly Thr Pro Asp Lys Gly Ala Leu Ala Glu Leu Arg Arg Thr 
            20                  25                  30          


Thr Ala Ile Thr Asp Lys Gly Ala Glu Lys Ile Trp Pro Leu Ile Phe 
        35                  40                  45              


Ser Val Val Pro Lys Leu Ser Thr Asn Gly Lys Pro Thr Lys Leu Glu 
    50                  55                  60                  


Thr Ala Val Tyr Thr Ala Leu His Cys Tyr Ala Ala Phe Gln Gln Gly 
65                  70                  75                  80  


Asn Asp Ser Phe Val Phe Gly Gln Ile Pro Arg Ser Lys Asp Lys Glu 
                85                  90                  95      


Glu Ser Gly Glu Asn Gly Val Ser Leu Phe Thr Ala Leu Arg Lys Met 
            100                 105                 110         


Lys Ile Asn Asp Ser Asn Glu Lys Lys Ala Leu Asp Arg Arg Val Thr 
        115                 120                 125             


Ala Leu Leu Ala Thr Thr Asn Ile Ser Ser Ala Thr Asn Ser Ile Asn 
    130                 135                 140                 


His Leu Val Ser Ile Leu Lys Gly Lys Lys Met Gly Glu Lys Ile Asp 
145                 150                 155                 160 


Phe Ala Gln Leu Ala Glu Asp Leu Tyr Asn Phe Gln Trp Ser Thr Lys 
                165                 170                 175     


Asn Ala Arg Phe Val Ala Leu Lys Trp Gly Lys Asp Tyr Tyr Trp Asn 
            180                 185                 190         


Val Tyr Lys Leu Ala Ser Asp Asn Asp 
        195                 200     


<210>  114
<211>  369
<212>  PRT
<213>  Lactobacillus crispatus

<400>  114

Met Asn Lys Asn Leu Tyr Met Asp Ile Asn Val Leu Gln Thr Val Pro 
1               5                   10                  15      


Ser Ser Asn Ile Asn Arg Asp Asp Thr Gly Ser Pro Lys Thr Ala Ile 
            20                  25                  30          


Tyr Gly Gly Val Thr Arg Ser Arg Val Ser Ser Gln Ser Trp Lys Arg 
        35                  40                  45              


Ala Met Arg Leu Ala Phe Lys Gln Asp Ser Glu Asn Glu Glu Trp Leu 
    50                  55                  60                  


Lys Ser Tyr Arg Thr Leu Lys Thr Ala Ser Leu Leu Ala Asn Lys Leu 
65                  70                  75                  80  


Gln Glu Leu Asp Ser Asn Leu Ser Glu Glu Asp Ala Leu Lys Lys Val 
                85                  90                  95      


Glu Glu Val Phe Lys Val Ala Gly Ile Lys Leu Lys Lys Asp Lys Lys 
            100                 105                 110         


Thr Gly Glu Met Leu Thr Gly Ala Leu Leu Leu Val Ser Glu Gly Gln 
        115                 120                 125             


Leu Glu Lys Ile Ala Lys Leu Ala Leu Ser Val Asp Gln Ile Asp Lys 
    130                 135                 140                 


Asp Thr Ala Lys Glu Ile Lys Lys Asn Leu Met Glu Asp Gln Ser Leu 
145                 150                 155                 160 


Asp Leu Ala Leu Phe Gly Arg Met Val Ala Asp Asn Pro Glu Leu Asn 
                165                 170                 175     


Val Asp Ala Ser Ser Gln Val Ala His Ala Ile Ser Thr His Glu Val 
            180                 185                 190         


Thr Pro Glu Phe Asp Tyr Tyr Thr Ala Val Asp Asp Ala Asn Thr Lys 
        195                 200                 205             


Ser Gln Thr Gly Ser Ala Met Leu Gly Thr Ile Glu Tyr Asn Ser Ser 
    210                 215                 220                 


Thr Leu Tyr Arg Tyr Ala Asn Val Asn Ile Leu Asp Leu Leu His Asn 
225                 230                 235                 240 


Leu Gly Asn Lys Asp Leu Thr Ile Glu Gly Ile Lys Leu Phe Ile Lys 
                245                 250                 255     


Glu Phe Val Leu Thr Met Pro Thr Gly Lys Glu Asn Thr Phe Ala Asn 
            260                 265                 270         


Lys Thr Leu Pro Gln Tyr Val Met Ile Asn Val Arg Thr Asp Thr Pro 
        275                 280                 285             


Val Asn Leu Val Ser Ala Phe Glu Thr Pro Val Arg Ser Glu Gly Gly 
    290                 295                 300                 


Tyr Val Asp Lys Ser Ile Asn Arg Leu Glu Asp Glu Tyr Lys Asn Ser 
305                 310                 315                 320 


Leu Lys Phe Val Asp Lys Pro Val Phe Asn Val Glu Leu Thr Asn Ser 
                325                 330                 335     


Glu Asn Ile Val Asp Asn Gln Ala Glu Asn Ile Asp Asp Leu Ile Asn 
            340                 345                 350         


Gln Thr Ala Glu Phe Val Lys Gln Glu Leu Glu Asn Glu Asp Ser Asn 
        355                 360                 365             


Asp 
    


<210>  115
<211>  241
<212>  PRT
<213>  Lactobacillus crispatus

<400>  115

Met Lys Thr Ala Thr Ile Arg Leu Thr Ala Pro Leu Gln Ser Tyr Gly 
1               5                   10                  15      


Asn Pro Ala Ser Phe Asn Gln Arg Thr Ser Asp Ser Tyr Pro Thr Lys 
            20                  25                  30          


Ser Ala Ile Val Gly Met Ile Ala Ala Ala Leu Gly Tyr Ala Arg Glu 
        35                  40                  45              


Asp Asn Glu Lys Thr Leu Glu Leu Asn Asn Leu Leu Phe Ala Val Arg 
    50                  55                  60                  


Ile Glu Gln Ser Gly Lys Met Leu Thr Glu Phe Gln Thr Val Glu Tyr 
65                  70                  75                  80  


Arg Lys Ser Ala Ser Lys Thr Ala Arg Lys Leu Thr Tyr Arg Asp Phe 
                85                  90                  95      


Ile Gln Asp Gly Val Phe Met Val Ala Ile Gly Ser Asp Asp Asp Gln 
            100                 105                 110         


Leu Ile Glu Asn Ile Lys Glu Ala Leu Glu His Pro Lys Phe Gln Leu 
        115                 120                 125             


Tyr Leu Gly Arg Arg Ser Asn Pro Pro Ala Gly Pro Leu Lys Ile Asp 
    130                 135                 140                 


Ile Phe Asn Gly Arg Asn Pro Leu Gln Val Leu Glu Asp Leu Pro Trp 
145                 150                 155                 160 


Gln Ala Ser Asp Trp Tyr Lys Arg Ser Phe Lys Thr Ser Gln Phe Leu 
                165                 170                 175     


Thr Arg Ile Ile Ala Asp Ala Ser Leu Asp Ser Glu Ser Thr Pro Leu 
            180                 185                 190         


Met Lys Lys Asp Lys Val Gly Ser Phe Asp Gln Lys Asp Arg Tyr Tyr 
        195                 200                 205             


Gln Tyr Arg Pro Val Val Ile Lys Lys Ala Val Lys Leu Lys Asn Ser 
    210                 215                 220                 


Glu Asn Asn Gln Thr Ala Asp Asn Thr Asp Trp Asp Phe Trp Ser Phe 
225                 230                 235                 240 


Val 
    


<210>  116
<211>  218
<212>  PRT
<213>  Lactobacillus crispatus

<400>  116

Met Tyr Ile Ser Arg Val Glu Ile Asp Thr Asn Asn Arg Gln Lys Ile 
1               5                   10                  15      


Arg Asp Leu Tyr His Leu Gly Ala Tyr His Asn Trp Val Glu Asn Cys 
            20                  25                  30          


Phe Pro Asp Glu Leu Lys Lys Lys Val Arg Leu Arg His Leu Trp Arg 
        35                  40                  45              


Ile Asp Glu Leu Asn Gly Lys Lys Tyr Leu Leu Val Leu Ser Glu Glu 
    50                  55                  60                  


Lys Pro Lys Leu Asp Lys Leu Glu Arg Tyr Gly Leu Ala Asn Thr Ala 
65                  70                  75                  80  


Glu Thr Lys Asp Tyr Asp His Phe Leu Ser Ser Leu Asn Gln Gly Lys 
                85                  90                  95      


Lys Tyr Arg Phe Lys Leu Thr Ala Asn Pro Ser Tyr Arg Ile Thr Asp 
            100                 105                 110         


Ala Lys Thr Gly Lys Ser Lys Val Val Pro His Ile Thr Val Leu Gln 
        115                 120                 125             


Gln Thr Lys Trp Leu Leu Asp Arg Ser Glu Lys Tyr Gly Phe Asp Leu 
    130                 135                 140                 


Val Lys Ser Glu Asp Asp Glu Glu Thr Tyr Glu Met Asn Ile Thr Ser 
145                 150                 155                 160 


Arg Asp Trp Pro Arg Leu Arg Arg Lys Gly Asn Lys Ile Val Lys Leu 
                165                 170                 175     


Ser Arg Val Thr Phe Glu Gly Leu Leu Glu Ile Lys Asp Leu Gln Gln 
            180                 185                 190         


Phe Lys Gln Ala Met Val Thr Gly Ile Gly Arg Glu Lys Ala Phe Gly 
        195                 200                 205             


Met Gly Leu Leu Thr Val Ile Pro Met Glu 
    210                 215             


<210>  117
<211>  315
<212>  PRT
<213>  Lactobacillus crispatus

<400>  117

Met Lys Asn Asn Tyr Gly Ala Lys Lys Pro Glu Arg Gln Glu Leu Gly 
1               5                   10                  15      


Arg Val Ser Asp Arg Ile Ser Phe Ile Tyr Val Glu His Ala Arg Ile 
            20                  25                  30          


Asn Arg Gln Asp Ser Ala Ile Gln Val Val Asp Tyr Arg Gly Ile Ile 
        35                  40                  45              


Asn Ile Pro Val Ala Leu Val Ser Val Leu Leu Leu Gly Pro Gly Val 
    50                  55                  60                  


Asp Val Thr His Arg Ala Met Glu Leu Met Gly Asp Ser Ser Leu Ala 
65                  70                  75                  80  


Val Val Trp Val Gly Glu Cys Gly Val Arg Gln Tyr Ala His Gly Arg 
                85                  90                  95      


Ser Leu Asn His Ser Ser Arg Leu Leu Glu Ala Gln Ala Lys Leu Val 
            100                 105                 110         


Ser Asn Arg Arg Ser Arg Leu Ala Thr Ala Arg Gln Met Tyr Glu Met 
        115                 120                 125             


Arg Phe Pro Asn Glu Asp Phe Ser Asn Leu Thr Met Glu Glu Leu Arg 
    130                 135                 140                 


Gly Lys Glu Gly Ser Arg Val Arg Arg Ile Tyr Arg Glu Gln Ser Lys 
145                 150                 155                 160 


Leu Thr Gly Val Ser Trp Asn Lys Arg Glu Tyr Lys Val Asp Asn Phe 
                165                 170                 175     


Glu Asp Gly Thr Pro Ile Asn Lys Ala Leu Thr Ala Ala His Gln Ala 
            180                 185                 190         


Leu Tyr Gly Leu Ser Tyr Ser Val Ile Val Ala Leu Gly Ala Ser Pro 
        195                 200                 205             


Gly Leu Gly Phe Ile His Thr Gly His Asp Leu Ala Phe Val Tyr Asp 
    210                 215                 220                 


Phe Ala Asp Leu Tyr Lys Ala Lys Tyr Ser Ile Pro Ile Ala Phe Lys 
225                 230                 235                 240 


Met Thr Ala Lys Tyr Gly Asn Gln Asp Ile Ala Thr His Thr Arg Ile 
                245                 250                 255     


Ala Met Arg Asp Glu Phe Lys Lys Gly Lys Leu Leu Ala Lys Met Val 
            260                 265                 270         


Lys Asp Leu Lys Thr Leu Leu Leu Lys Asp Ser Thr Ala Asp Ile Glu 
        275                 280                 285             


Ser Pro Gln Val Ile Met Ser Leu Trp Asp Asp Arg Glu Gly Leu Gln 
    290                 295                 300                 


Lys Phe Gly Val Gln Tyr His Glu Ala Gln Ser 
305                 310                 315 


<210>  118
<211>  298
<212>  PRT
<213>  Lactobacillus crispatus

<400>  118

Met Ile Val Ile Thr Leu Ser Lys Thr Pro Gln Ser Leu Arg Gly Asp 
1               5                   10                  15      


Leu Thr Lys Trp Cys Gln Glu Val Gln Thr Gly Val Tyr Val Gly Asn 
            20                  25                  30          


Phe Ser Ala Arg Ile Arg Asp Leu Ile Trp Gln Arg Ile Ile Ser Asn 
        35                  40                  45              


Ile Gly Gln Gly Glu Ala Thr Leu Ile Tyr Ser Thr Asn Asn Glu Leu 
    50                  55                  60                  


Gly Phe Asp Phe Lys Thr Thr Arg Gln Asp Lys Met Val Ala Asp Phe 
65                  70                  75                  80  


Asp Gly Ile Pro Leu Met Val His Leu Asn Ser Gln Asn Lys Leu Ser 
                85                  90                  95      


Ser Lys Lys Lys Leu Gly Phe Ser Lys Ala Ala Gln His His Lys Val 
            100                 105                 110         


Asn Thr Phe Arg Ser Gln Val Gln Asp Lys Ala Asp Ser Leu Thr Ser 
        115                 120                 125             


Leu Ala Val Leu Asp Ile Glu Thr Thr Gly Leu Asn Leu Glu Lys Asp 
    130                 135                 140                 


Lys Ile Ile Ser Ile Gly Ala Ile Lys Tyr Leu Glu Asn Asn Asp Cys 
145                 150                 155                 160 


Glu Lys Phe Tyr Arg Leu Ile Lys Val Asp Thr Glu Val Pro Asp Asn 
                165                 170                 175     


Ile Glu Lys Ile Thr Gln Leu Asn Lys Gly Val Leu Ala Asn Lys Gly 
            180                 185                 190         


Ile Asp Ile Lys Thr Ala Leu Leu Asp Leu Arg Lys Phe Leu Ala Asp 
        195                 200                 205             


Arg Ile Val Val Gly Tyr Asn Leu Pro Phe Asp Ile Asn Phe Leu Asn 
    210                 215                 220                 


Arg Asp Phe Lys Lys Tyr Cys His Tyr Ser Leu Leu Asn Glu Cys Val 
225                 230                 235                 240 


Asp Leu Leu Ser Ala Val Lys Lys Lys Asn Val Phe Leu Asp Asn Tyr 
                245                 250                 255     


His Leu Ser Thr Val Leu Glu Asn Tyr Asn Ile Lys Asn Ser Asn Pro 
            260                 265                 270         


His Asn Ser Leu Ala Asp Ala Val Ala Thr Met Glu Leu Leu Lys Lys 
        275                 280                 285             


Leu Ile Lys Asn Asp Asn Tyr Lys Ile Lys 
    290                 295             


<210>  119
<211>  916
<212>  PRT
<213>  Lactobacillus crispatus

<400>  119

Met Thr Asn Leu Ser Asn Thr Thr Leu Ser Leu Trp Gly Lys Lys Asn 
1               5                   10                  15      


Ile Asn Glu Asp Ser Glu Glu Val Trp Leu Pro Leu Ile Ala His Leu 
            20                  25                  30          


Ile Asp Thr Lys Asn Val Ile Gly Trp Leu Tyr Asn His Trp Leu Asn 
        35                  40                  45              


Asp Gly Gln Arg Cys Ile Leu Ser Gln Gly Phe Glu Asn Ser Asn Glu 
    50                  55                  60                  


Val Gln Asn Leu Val Glu Phe Ile Gly Tyr Ile His Asp Ile Gly Lys 
65                  70                  75                  80  


Ala Thr Pro Ala Phe Gln Ile Lys Gln Ser Phe Ile His Asn Glu Asp 
                85                  90                  95      


Leu Asp Gln Asp Leu Leu Glu Arg Leu Leu Gln Asn Gly Phe Asp Asn 
            100                 105                 110         


Leu Glu Glu Leu Lys Ala Asn Met Asp Thr Arg His Trp Leu His Ala 
        115                 120                 125             


Leu Ala Gly Glu Val Ile Leu Glu Asn Ser Gly Leu Asn Glu Ser Ile 
    130                 135                 140                 


Gly Ala Ile Val Gly Gly His His Gly Lys Pro Gln Asn Lys Tyr Phe 
145                 150                 155                 160 


Asp Tyr Glu Asp Gln Leu Met Asp Asp Thr Ser Lys Tyr Tyr Gln Ser 
                165                 170                 175     


Asp Ser Trp Ala Glu Asn Pro Thr Arg Glu Lys Trp Glu Asn Val Gln 
            180                 185                 190         


Lys Glu Ile Ile Asn Tyr Gly Leu Asp Leu Cys Asn Phe Lys Asn Leu 
        195                 200                 205             


Glu Asp Ile Pro Thr Val Thr Asp Ser Gln Ala Val Ile Leu Glu Gly 
    210                 215                 220                 


Leu Val Ile Met Ala Asp Trp Leu Ala Ser Ser Glu Tyr Thr Ile Lys 
225                 230                 235                 240 


Asp Gly Lys Arg Val Ser Met Phe Pro Leu Ile Ser Met Asp Gln Gly 
                245                 250                 255     


Phe Ser Asp Ile Asp Met Thr Ser Arg Tyr Gln Gln Gly Ile Leu Asn 
            260                 265                 270         


Trp Leu Lys Thr Asp Ser Trp Thr Pro Gln Leu Ile Val Asp Thr Lys 
        275                 280                 285             


Glu Gln Tyr Gln Lys Arg Trp Asn Phe Asp Pro Arg Gln Val Gln Glu 
    290                 295                 300                 


Gln Met Ser Gln Ala Ile Gly Asp Ser Val Asp Pro Ser Met Ile Ile 
305                 310                 315                 320 


Val Glu Ala Pro Met Gly Ile Gly Lys Thr Glu Ile Ala Leu Thr Ala 
                325                 330                 335     


Val Glu Gln Leu Ala Ala Lys Thr Gly Ile Asn Gly Leu Phe Phe Gly 
            340                 345                 350         


Leu Pro Thr Gln Ala Thr Ala Asn Ala Met Phe Asp Arg Val Asp Asn 
        355                 360                 365             


Trp Leu Gly Asn Ile Ala Lys Glu Gln Ser Glu Asn Leu Ser Ile Lys 
    370                 375                 380                 


Leu Met His Gly Lys Ala Gln Phe Asn Gln Lys Tyr His Asn Ile Pro 
385                 390                 395                 400 


Asp Ala Asp Asp Ile Glu Thr Asp Glu Gly Ala Val Val Val Asn Gln 
                405                 410                 415     


Trp Phe Asn Gly Lys Lys Ser Ile Leu Thr Asp Phe Val Ile Gly Thr 
            420                 425                 430         


Ile Asp Gln Leu Leu Leu Met Gly Leu Lys Gln Lys His Leu Ala Leu 
        435                 440                 445             


Arg His Leu Gly Leu Ser Gly Lys Ile Val Val Ile Asp Glu Val His 
    450                 455                 460                 


Ala Tyr Asp Val Tyr Met Ser Ser Tyr Leu Glu Lys Ala Ile Glu Trp 
465                 470                 475                 480 


Leu Gly Ala Tyr His Val Pro Val Val Ala Leu Ser Ala Thr Leu Pro 
                485                 490                 495     


Val Asp Lys Arg Asn Glu Leu Leu Thr Ala Tyr Cys Arg Gly Lys Tyr 
            500                 505                 510         


Gly Ser Glu Lys Phe Lys Ala Gln Asn Thr Asn Trp Gln Thr Cys Gln 
        515                 520                 525             


Ala Tyr Pro Leu Leu Ser Ile Leu Asp Gly Lys Val Leu Lys Gln Lys 
    530                 535                 540                 


Ser Asp Phe Ser Thr Lys Ala Asp Asp Thr Thr Val Lys Val Thr Arg 
545                 550                 555                 560 


Leu Ser Ile Glu Asn Tyr Asp Leu Ile Glu Lys Ile Asn Asp Gln Ile 
                565                 570                 575     


Glu Asp Gly Gly Val Ala Gly Val Ile Val Asn Thr Val Lys Arg Ala 
            580                 585                 590         


Gln Glu Leu Ala Lys Ile Ala Glu Lys Glu Cys Ser Glu Asp Thr Gln 
        595                 600                 605             


Ile Leu Val Leu His Ser Ala Phe Leu Ala Asn Asp Arg Ser Asn Leu 
    610                 615                 620                 


Glu Ser Lys Leu Glu Lys Ser Ile Gly Asn His Gln Lys Arg Pro Lys 
625                 630                 635                 640 


Lys Met Ile Val Ile Gly Thr Gln Val Leu Glu Gln Ser Leu Asp Ile 
                645                 650                 655     


Asp Phe Asp Val Met Tyr Thr Asp Ile Ala Pro Ile Asp Leu Ile Leu 
            660                 665                 670         


Gln Arg Ala Gly Arg Leu His Arg His Gln Val Lys Arg Pro Asp Lys 
        675                 680                 685             


Leu Ile Glu Pro Gln Leu Phe Ile Met Gly Ile Asn Ser Asn Gly Asp 
    690                 695                 700                 


Tyr Gly Asp Ala Asn Gln Ala Ile Tyr Glu Lys Tyr Leu Leu Ile Lys 
705                 710                 715                 720 


Thr Asp His Phe Leu Lys Asp Asn Ile Lys Leu Pro Ser Asp Ile Ser 
                725                 730                 735     


Asn Leu Val Gln Lys Val Tyr Ser Ala Asp Thr Asp Asn Glu Val Gln 
            740                 745                 750         


Asp Leu Gln Glu Ala Glu Val Lys Lys Phe Asn Ile Asp Gln Glu Lys 
        755                 760                 765             


Ala Glu Gln Lys Ser Lys Gly Tyr Gln Ile Arg Ala Pro Arg Val Glu 
    770                 775                 780                 


Lys Thr Leu His Gly Trp Leu Asp Asn Asp Ser Asp Thr Asp Leu Asn 
785                 790                 795                 800 


Asp Val Lys Ala Glu Ala Ala Val Arg Asp Thr Asn Glu Thr Ile Glu 
                805                 810                 815     


Val Leu Leu Leu Lys Lys Asp Ala Asp Gly Phe Tyr Leu Met Asp Gly 
            820                 825                 830         


Arg Lys Val Asp Glu Glu Val Pro Asp Ser Val Val Ala Gln Gln Leu 
        835                 840                 845             


Ile Arg Leu Pro His Ala Leu Thr Met Asp Ile Asn Gln Ser Ile Arg 
    850                 855                 860                 


Asn Leu Glu Arg Asp Thr Ile Ser Asn Phe Pro Glu Trp Gln Asn Ser 
865                 870                 875                 880 


Ser Trp Leu Lys Gly Ser Val Ala Leu Ile Leu Asp Ala Asn Asn Glu 
                885                 890                 895     


Thr Glu Phe Asn Gly Tyr Lys Ile Lys Tyr Ser Ser Asp Leu Gly Leu 
            900                 905                 910         


Ser Tyr Glu Lys 
        915     


<210>  120
<211>  103
<212>  DNA
<213>  Lactobacillus crispatus

<400>  120
actcttaacc ttattgatct aacaatcata atttaaaatc aagcaatgcg ttttagtacg       60

cagagtttca acacttgtcc cgagctatcg agggactttt ttt                        103


<210>  121
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  crRNA/crDNA

<400>  121
tagaaaatgg tttatttgta ccatcttcta gttttagatg attgttagat caatgaggtt       60

tagatc                                                                  66


<210>  122
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  crRNA/crDNA

<400>  122
taccttgaat tactccagta actctgccgg aatacagtat ttatttatct taagagaaat       60

gtaaat                                                                  66


<210>  123
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  crRNA/crDNA

<400>  123
taccttgaat tactccagta actctgccgg aatacagtat ttatttatct taagagaaat       60

gtaaat                                                                  66


<210>  124
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  124
atctcagttt aggtaccatt ttttgacgat caaaatc                                37


<210>  125
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  125
atctaaacag tttaggtacc attttttgac gatcaaaatc                             40


<210>  126
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  126
atctcagttc aaatgttact tggccacgca aatataa                                37


<210>  127
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  127
atctaaacag ttcaaatgtt acttggccac gcaaatataa                             40


<210>  128
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  128
atctcgtgtt gtttccatat tcattagata aaacatc                                37


<210>  129
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid sequence

<400>  129
atctaaacgt gttgtttcca tattcattag ataaaacatc                             40


<210>  130
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  NCK1350 wt for p-gtf gene

<400>  130
atgatgctaa tggagaaact acaagttaat ccggcaaagc taaatggccg gcccgtatat       60


<210>  131
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  NCK2635 (deletion of the p-gtf)

<400>  131
atgatgctaa tggagaaagc gaataaatga ataaaagaat ctgcgttctt cacgttgca        59


<210>  132
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  NCK2656 (insertion of stop codons)

<400>  132
atgatgctaa tggagaaata atagtgaccc gtatatcata cagttaagcg agtatttgat       60


<210>  133
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  NCK2659 (single base substitution)

<400>  133
atgatgctaa tggagagact acaagttaat ccggcaaagc taaatggccg gcccgtatat       60


<210>  134
<211>  246
<212>  DNA
<213>  Artificial

<220>
<223>  NCK1350 wt for prophage DNA packaging NU1 gene

<400>  134
aatggaattt aaattagatg aatcacaaga aaccgagatt aaaacttttg ttatgggcgt       60

ggttaaagac gctattaaac aagccactac caccagcaaa ccatatttga accgcaaaga      120

aattgctaag tattttggcg tggctgaatc aactattaca tattgggctt ctttagggat      180

gcctgtcgct gtcatagacg ggcgcaaact ctatggcaag caatctataa ctaactggct      240

aaaatt                                                                 246


<210>  135
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  NCK2667

<400>  135
aacaagaaat attattacag cgtgcaagtg ggctaatctt aggtatttaa tacttaacc        59


<210>  136
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  NCK1350 wt for enolase gene

<400>  136
gaaattgtac tcggttaact cgaaattaat cgtgatcaac atcgtctggg aagaaggcaa       60


<210>  137
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  NCK2665 (chromosomal insertion of GFP downstream enolase)

<400>  137
tttacgcatt aataaacctc ctcacttaat cgtgatcaac atcgtctggg aagaaggcaa       60


<210>  138
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  p-gtf sequence

<400>  138
atgatgctaa tggagaaact acaagttaat ccggcaaagc taaatggccg gcccgta          57


<210>  139
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  p-gtf sequence

<400>  139
gccaataaat gaataa                                                       16


<210>  140
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  repair template

<400>  140
atgatgctaa tggagaaa                                                     18


<210>  141
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  repair template

<400>  141
gcgaataaat gaataa                                                       16


<210>  142
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  repair template

<400>  142
atgatgctaa tggagaaa                                                     18


<210>  143
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  repair template

<400>  143
taatagtgac ccgtata                                                      17


<210>  144
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  repair template

<400>  144
atgatgctaa tggagagact acaagttaat ccggcaaagc taaatggccg gccctata         58


<210>  145
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Nu1 sequence

<400>  145
aatggaggac atcaaaaatg                                                   20


<210>  146
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Nu1 sequence

<400>  146
gacggcgcaa actctatggc aagcaatcta taactaactg gctaaa                      46


<210>  147
<211>  10
<212>  DNA
<213>  Artificial

<220>
<223>  Nu1 sequence

<400>  147
acaagaaata                                                              10


<210>  148
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  repair template

<400>  148
aatggaggac atcaaaa                                                      17


<210>  149
<211>  10
<212>  DNA
<213>  Artificial

<220>
<223>  repair template

<400>  149
acaagaaata                                                              10


<210>  150
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  enolase

<400>  150
tttttttgaa attgtactcg gttaactcga aattaatcgt gatcaacatc gtctgggaag       60

aaggcaagac gttcaccatc gccaagt                                           87


<210>  151
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  repair template

<400>  151
ctcggttaac tcg                                                          13


<210>  152
<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  repair template

<400>  152
tacgcattaa taaacctcct cacttaatcg tgatcaacat cgtctgggaa gaaggcaaga       60

cgttcaccat cgccaagt                                                     78


<210>  153
<211>  36
<212>  DNA
<213>  Lactobacillus crispatus

<400>  153
gttttagatg attgttagat caatgaggtt tagatc                                 36


<210>  154
<211>  38
<212>  DNA
<213>  Lactobacillus crispatus

<400>  154
gtattctcca cgcatgtgga ggtgtgtgga ggtgatcc                               38


<210>  155
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  155
gtattctcca cacatgtgga ggtgatcc                                          28


<210>  156
<211>  30
<212>  DNA
<213>  Lactobacillus crispatus

<400>  156
gtatttattt atcttaagag aaatgtaaat                                        30


<210>  157
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  157
gtattctcca cgcatgtgga ggtgatcc                                          28


<210>  158
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  158
gtattctcca cgagtgtggg gatcctat                                          28


<210>  159
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  159
gtattctcca cgtatgtgga ggtgatcc                                          28


<210>  160
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  160
gtattctcca cgtatgtgga ggtcatcc                                          28


<210>  161
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  161
gtattctcca cgcgtgtgga ggtgatcc                                          28


<210>  162
<211>  29
<212>  DNA
<213>  Lactobacillus crispatus

<400>  162
gtattctcca cgtatgtgga ggtgatccc                                         29


<210>  163
<211>  28
<212>  DNA
<213>  Lactobacillus crispatus

<400>  163
gtattctcca cgtgtgtgga ggtgatcc                                          28


<210>  164
<211>  29
<212>  DNA
<213>  Lactobacillus crispatus

<400>  164
gtattctcca cgtgtgtgga ggtgatcct                                         29


<210>  165
<211>  38
<212>  DNA
<213>  Lactobacillus crispatus

<400>  165
ttcgtgatta gtttgatctc gttgttgtaa gcgacgaa                               38


<210>  166
<211>  38
<212>  DNA
<213>  Lactobacillus crispatus

<400>  166
aaattaacac ctctattatt tttttctgta agatactt                               38


<210>  167
<211>  38
<212>  DNA
<213>  Lactobacillus crispatus

<400>  167
cccacgttgg taccttcgca aaagctattg ggcgccac                               38


<210>  168
<211>  37
<212>  DNA
<213>  Lactobacillus crispatus

<400>  168
aaaaaaagga ttatctgtac catcatctaa cggcgta                                37


<210>  169
<211>  38
<212>  DNA
<213>  Lactobacillus crispatus

<400>  169
cagaaaatgg tttatttgtc atttcttcat ggcgggct                               38


<210>  170
<211>  38
<212>  DNA
<213>  Lactobacillus crispatus

<400>  170
cagaaaatgg tttatttgtc atttcttcat ggcgggct                               38


<210>  171
<211>  38
<212>  DNA
<213>  Lactobacillus crispatus

<400>  171
taaaaaaagg attatctgta ccatcatcta acggcgta                               38


<210>  172
<211>  38
<212>  DNA
<213>  Lactobacillus crispatus

<400>  172
cagaaaatgg tttatttgtc atttcttcat ggcgggct                               38


<210>  173
<211>  38
<212>  DNA
<213>  Lactobacillus crispatus

<400>  173
cccacgttgg taccttcgca aaagctattg ggcgccac                               38


<210>  174
<211>  42
<212>  DNA
<213>  Lactobacillus crispatus

<400>  174
gtccaccgta actaagaacg acaggatctt tttctaggtc aa                          42


<210>  175
<211>  42
<212>  DNA
<213>  Lactobacillus crispatus

<400>  175
tttatggtgt atcaagaaca acagattcag tttttagttc aa                          42


<210>  176
<211>  44
<212>  DNA
<213>  Lactobacillus crispatus

<400>  176
gttgatgggt tatgggaaaa tgcccgttca aaaaatcttt ataa                        44


<210>  177
<211>  37
<212>  DNA
<213>  Lactobacillus crispatus

<400>  177
gttgatggga aaatgcccgt tcaaaaaatc tctataa                                37


<210>  178
<211>  43
<212>  DNA
<213>  Lactobacillus crispatus

<400>  178
acctggtgca acagcaacta ctcctgtaac tctgcctgca aac                         43


<210>  179
<211>  45
<212>  DNA
<213>  Lactobacillus crispatus

<400>  179
cctgccgggg atggtgaatc cctcggcagg gcgcatttac agtcg                       45


<210>  180
<211>  46
<212>  DNA
<213>  Lactobacillus crispatus

<400>  180
gatttaccgt taatagaatc tggcgataaa gtcaacattg ttctgc                      46


<210>  181
<211>  42
<212>  DNA
<213>  Lactobacillus crispatus

<400>  181
gcttcaaaca tgggtgagat tatccggaaa ggataagata tg                          42


<210>  182
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  182
agccttaaca gatggattaa acaattttta acggctggtt t                           41


<210>  183
<211>  39
<212>  DNA
<213>  Lactobacillus crispatus

<400>  183
aatcgaaagt ccgcatgact tcgttgacaa tagctctca                              39


<210>  184
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  184
tcaattaact aacaatgctc aaacgttaaa tatggttgat a                           41


<210>  185
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  185
aaaattaact aacaacgcac aaacgttaaa tttggttgat a                           41


<210>  186
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  186
aagcacaaac cttgcataaa tcgagcgatc cgaccagcat a                           41


<210>  187
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  187
tgccgtaaca attgacatgg caaaagagct ttgcatgatg t                           41


<210>  188
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  188
ttaactaaca atgctcaaac gttaaatatg gttgataaag a                           41


<210>  189
<211>  40
<212>  DNA
<213>  Lactobacillus crispatus

<400>  189
ataaaaaata ggcgattccg caatacttgc gaacctatcg                             40


<210>  190
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  190
ttaactaaca atgctcaaac gttaaatatg gttgataaag a                           41


<210>  191
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  191
gggcttaatt gtatcaatgc taataagaat gttctgcccg g                           41


<210>  192
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  192
catgaaaata atctgctact tttgctaaat cttcagcttt t                           41


<210>  193
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  193
gaaattaatg ttggtgcatt aatggaagat gcatatttag a                           41


<210>  194
<211>  41
<212>  DNA
<213>  Lactobacillus crispatus

<400>  194
ctgctcaatt agttaaaggt tttggtggtt tggcttctgc g                           41


<210>  195
<211>  246
<212>  DNA
<213>  Escherichia coli

<400>  195
aatggaattt aaattagatg aatcacaaga aaccgagatt aaaacttttg ttatgggcgt       60

ggttaaagac gctattaaac aagccactac caccagcaaa ccatatttga accgcaaaga      120

aattgctaag tattttggcg tggctgaatc aactattaca tattgggctt ctttagggat      180

gcctgtcgct gtcatagacg ggcgcaaact ctatggcaag caatctataa ctaactggct      240

aaaatt                                                                 246


