                         SEQUENCE LISTING

<110>  NOVARTIS INSTITUTE FOR BIOMEDICAL RESEARCH INC.
 
<120>  SUSTAINED DELIVERY OF ANGIOPOETIN-LIKE 3 PEPTIDES

<130>  PPR0672-US-PSP

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser 
1               5                   10                  15      


Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
    130                 135                 140                 


Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu 
145                 150                 155                 160 


Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 
                165                 170                 175     


Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln 
            180                 185                 190         


His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile 
        195                 200                 205             


Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg 
    210                 215                 220                 


Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
225                 230                 235                 240 


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
                245                 250                 255     


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            260                 265                 270         


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        275                 280                 285             


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    290                 295                 300                 


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
305                 310                 315                 320 


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                325                 330                 335     


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            340                 345                 350         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        355                 360                 365             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    370                 375                 380                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
385                 390                 395                 400 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                405                 410                 415     


Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            420                 425                 430         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        435                 440                 445             


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    450                 455                 460 


<210>  2
<211>  2126
<212>  DNA
<213>  Homo sapiens

<400>  2
ttccagaaga aaacagttcc acgttgcttg aaattgaaaa tcaagataaa aatgttcaca       60

attaagctcc ttctttttat tgttcctcta gttatttcct ccagaattga tcaagacaat      120

tcatcatttg attctctatc tccagagcca aaatcaagat ttgctatgtt agacgatgta      180

aaaattttag ccaatggcct ccttcagttg ggacatggtc ttaaagactt tgtccataag      240

acgaagggcc aaattaatga catatttcaa aaactcaaca tatttgatca gtctttttat      300

gatctatcgc tgcaaaccag tgaaatcaaa gaagaagaaa aggaactgag aagaactaca      360

tataaactac aagtcaaaaa tgaagaggta aagaatatgt cacttgaact caactcaaaa      420

cttgaaagcc tcctagaaga aaaaattcta cttcaacaaa aagtgaaata tttagaagag      480

caactaacta acttaattca aaatcaacct gaaactccag aacacccaga agtaacttca      540

cttaaaactt ttgtagaaaa acaagataat agcatcaaag accttctcca gaccgtggaa      600

gaccaatata aacaattaaa ccaacagcat agtcaaataa aagaaataga aaatcagctc      660

agaaggacta gtattcaaga acccacagaa atttctctat cttccaagcc aagagcacca      720

agaactactc cctttcttca gttgaatgaa ataagaaatg taaaacatga tggcattcct      780

gctgaatgta ccaccattta taacagaggt gaacatacaa gtggcatgta tgccatcaga      840

cccagcaact ctcaagtttt tcatgtctac tgtgatgtta tatcaggtag tccatggaca      900

ttaattcaac atcgaataga tggatcacaa aacttcaatg aaacgtggga gaactacaaa      960

tatggttttg ggaggcttga tggagaattt tggttgggcc tagagaagat atactccata     1020

gtgaagcaat ctaattatgt tttacgaatt gagttggaag actggaaaga caacaaacat     1080

tatattgaat attcttttta cttgggaaat cacgaaacca actatacgct acatctagtt     1140

gcgattactg gcaatgtccc caatgcaatc ccggaaaaca aagatttggt gttttctact     1200

tgggatcaca aagcaaaagg acacttcaac tgtccagagg gttattcagg aggctggtgg     1260

tggcatgatg agtgtggaga aaacaaccta aatggtaaat ataacaaacc aagagcaaaa     1320

tctaagccag agaggagaag aggattatct tggaagtctc aaaatggaag gttatactct     1380

ataaaatcaa ccaaaatgtt gatccatcca acagattcag aaagctttga atgaactgag     1440

gcaaatttaa aaggcaataa tttaaacatt aacctcattc caagttaatg tggtctaata     1500

atctggtatt aaatccttaa gagaaagctt gagaaataga ttttttttat cttaaagtca     1560

ctgtctattt aagattaaac atacaatcac ataaccttaa agaataccgt ttacatttct     1620

caatcaaaat tcttataata ctatttgttt taaattttgt gatgtgggaa tcaattttag     1680

atggtcacaa tctagattat aatcaatagg tgaacttatt aaataacttt tctaaataaa     1740

aaatttagag acttttattt taaaaggcat catatgagct aatatcacaa ctttcccagt     1800

ttaaaaaact agtactcttg ttaaaactct aaacttgact aaatacagag gactggtaat     1860

tgtacagttc ttaaatgttg tagtattaat ttcaaaacta aaaatcgtca gcacagagta     1920

tgtgtaaaaa tctgtaatac aaatttttaa actgatgctt cattttgcta caaaataatt     1980

tggagtaaat gtttgatatg atttatttat gaaacctaat gaagcagaat taaatactgt     2040

attaaaataa gttcgctgtc tttaaacaaa tggagatgac tactaagtca cattgacttt     2100

aacatgaggt atcactatac cttatt                                          2126


<210>  3
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 K423Q

<400>  3

Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser 
1               5                   10                  15      


Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
    130                 135                 140                 


Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu 
145                 150                 155                 160 


Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 
                165                 170                 175     


Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln 
            180                 185                 190         


His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile 
        195                 200                 205             


Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg 
    210                 215                 220                 


Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
225                 230                 235                 240 


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
                245                 250                 255     


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            260                 265                 270         


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        275                 280                 285             


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    290                 295                 300                 


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
305                 310                 315                 320 


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                325                 330                 335     


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            340                 345                 350         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        355                 360                 365             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    370                 375                 380                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
385                 390                 395                 400 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                405                 410                 415     


Tyr Asn Lys Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            420                 425                 430         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        435                 440                 445             


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    450                 455                 460 


<210>  4
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 K423S

<400>  4

Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser 
1               5                   10                  15      


Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
    130                 135                 140                 


Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu 
145                 150                 155                 160 


Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 
                165                 170                 175     


Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln 
            180                 185                 190         


His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile 
        195                 200                 205             


Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg 
    210                 215                 220                 


Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
225                 230                 235                 240 


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
                245                 250                 255     


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            260                 265                 270         


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        275                 280                 285             


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    290                 295                 300                 


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
305                 310                 315                 320 


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                325                 330                 335     


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            340                 345                 350         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        355                 360                 365             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    370                 375                 380                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
385                 390                 395                 400 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                405                 410                 415     


Tyr Asn Lys Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            420                 425                 430         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        435                 440                 445             


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    450                 455                 460 


<210>  5
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 207-460 K423Q

<400>  5

Ile Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro 
1               5                   10                  15      


Arg Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His 
            20                  25                  30          


Asp Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His 
        35                  40                  45              


Thr Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His 
    50                  55                  60                  


Val Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His 
65                  70                  75                  80  


Arg Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys 
                85                  90                  95      


Tyr Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys 
            100                 105                 110         


Ile Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu 
        115                 120                 125             


Glu Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu 
    130                 135                 140                 


Gly Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly 
145                 150                 155                 160 


Asn Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr 
                165                 170                 175     


Trp Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser 
            180                 185                 190         


Gly Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly 
        195                 200                 205             


Lys Tyr Asn Lys Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly 
    210                 215                 220                 


Leu Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr 
225                 230                 235                 240 


Lys Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
                245                 250             


<210>  6
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 207-460 K423S

<400>  6

Ile Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro 
1               5                   10                  15      


Arg Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His 
            20                  25                  30          


Asp Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His 
        35                  40                  45              


Thr Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His 
    50                  55                  60                  


Val Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His 
65                  70                  75                  80  


Arg Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys 
                85                  90                  95      


Tyr Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys 
            100                 105                 110         


Ile Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu 
        115                 120                 125             


Glu Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu 
    130                 135                 140                 


Gly Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly 
145                 150                 155                 160 


Asn Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr 
                165                 170                 175     


Trp Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser 
            180                 185                 190         


Gly Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly 
        195                 200                 205             


Lys Tyr Asn Lys Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly 
    210                 215                 220                 


Leu Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr 
225                 230                 235                 240 


Lys Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
                245                 250             


<210>  7
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 225-460 K423Q

<400>  7

Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
1               5                   10                  15      


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
            20                  25                  30          


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
        35                  40                  45              


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
    50                  55                  60                  


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
65                  70                  75                  80  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
                85                  90                  95      


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
            100                 105                 110         


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
        115                 120                 125             


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
    130                 135                 140                 


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
145                 150                 155                 160 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
                165                 170                 175     


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
            180                 185                 190         


Tyr Asn Lys Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu 
        195                 200                 205             


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
    210                 215                 220                 


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230                 235     


<210>  8
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 225-460 K423S

<400>  8

Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
1               5                   10                  15      


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
            20                  25                  30          


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
        35                  40                  45              


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
    50                  55                  60                  


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
65                  70                  75                  80  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
                85                  90                  95      


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
            100                 105                 110         


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
        115                 120                 125             


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
    130                 135                 140                 


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
145                 150                 155                 160 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
                165                 170                 175     


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
            180                 185                 190         


Tyr Asn Lys Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu 
        195                 200                 205             


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
    210                 215                 220                 


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230                 235     


<210>  9
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 225-460 S424T

<400>  9

Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
1               5                   10                  15      


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
            20                  25                  30          


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
        35                  40                  45              


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
    50                  55                  60                  


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
65                  70                  75                  80  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
                85                  90                  95      


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
            100                 105                 110         


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
        115                 120                 125             


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
    130                 135                 140                 


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
145                 150                 155                 160 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
                165                 170                 175     


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
            180                 185                 190         


Tyr Asn Lys Pro Arg Ala Lys Thr Lys Pro Glu Arg Arg Arg Gly Leu 
        195                 200                 205             


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
    210                 215                 220                 


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230                 235     


<210>  10
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 226-460 K423Q

<400>  10

Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly 
1               5                   10                  15      


Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
            20                  25                  30          


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
        35                  40                  45              


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
    50                  55                  60                  


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
65                  70                  75                  80  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
                85                  90                  95      


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
            100                 105                 110         


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
        115                 120                 125             


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
    130                 135                 140                 


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
145                 150                 155                 160 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
                165                 170                 175     


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
            180                 185                 190         


Asn Lys Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
        195                 200                 205             


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
    210                 215                 220                 


Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230                 235 


<210>  11
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 226-460 K423S

<400>  11

Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly 
1               5                   10                  15      


Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
            20                  25                  30          


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
        35                  40                  45              


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
    50                  55                  60                  


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
65                  70                  75                  80  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
                85                  90                  95      


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
            100                 105                 110         


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
        115                 120                 125             


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
    130                 135                 140                 


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
145                 150                 155                 160 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
                165                 170                 175     


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
            180                 185                 190         


Asn Lys Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
        195                 200                 205             


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
    210                 215                 220                 


Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230                 235 


<210>  12
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 228-460 K423Q

<400>  12

Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro 
1               5                   10                  15      


Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met 
            20                  25                  30          


Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp 
        35                  40                  45              


Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly 
    50                  55                  60                  


Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly 
65                  70                  75                  80  


Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile 
                85                  90                  95      


Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys 
            100                 105                 110         


Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu 
        115                 120                 125             


Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val Pro Asn 
    130                 135                 140                 


Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys 
145                 150                 155                 160 


Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp 
                165                 170                 175     


Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys 
            180                 185                 190         


Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys 
        195                 200                 205             


Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile 
    210                 215                 220                 


His Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230             


<210>  13
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 228-460 K423S

<400>  13

Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro 
1               5                   10                  15      


Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met 
            20                  25                  30          


Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp 
        35                  40                  45              


Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly 
    50                  55                  60                  


Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly 
65                  70                  75                  80  


Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile 
                85                  90                  95      


Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys 
            100                 105                 110         


Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu 
        115                 120                 125             


Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val Pro Asn 
    130                 135                 140                 


Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys 
145                 150                 155                 160 


Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp 
                165                 170                 175     


Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys 
            180                 185                 190         


Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys 
        195                 200                 205             


Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile 
    210                 215                 220                 


His Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230             


<210>  14
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 228-460 S424T

<400>  14

Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro 
1               5                   10                  15      


Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met 
            20                  25                  30          


Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp 
        35                  40                  45              


Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly 
    50                  55                  60                  


Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly 
65                  70                  75                  80  


Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile 
                85                  90                  95      


Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys 
            100                 105                 110         


Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu 
        115                 120                 125             


Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val Pro Asn 
    130                 135                 140                 


Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys 
145                 150                 155                 160 


Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp 
                165                 170                 175     


Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys 
            180                 185                 190         


Pro Arg Ala Lys Thr Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys 
        195                 200                 205             


Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile 
    210                 215                 220                 


His Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230             


<210>  15
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 233-460 K423Q

<400>  15

Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro Ala Glu Cys Thr Thr 
1               5                   10                  15      


Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met Tyr Ala Ile Arg Pro 
            20                  25                  30          


Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp Val Ile Ser Gly Ser 
        35                  40                  45              


Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly Ser Gln Asn Phe Asn 
    50                  55                  60                  


Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly Arg Leu Asp Gly Glu 
65                  70                  75                  80  


Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile Val Lys Gln Ser Asn 
                85                  90                  95      


Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys Asp Asn Lys His Tyr 
            100                 105                 110         


Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu Thr Asn Tyr Thr Leu 
        115                 120                 125             


His Leu Val Ala Ile Thr Gly Asn Val Pro Asn Ala Ile Pro Glu Asn 
    130                 135                 140                 


Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys Ala Lys Gly His Phe 
145                 150                 155                 160 


Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp Trp His Asp Glu Cys 
                165                 170                 175     


Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys Pro Arg Ala Gln Ser 
            180                 185                 190         


Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys Ser Gln Asn Gly Arg 
        195                 200                 205             


Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile His Pro Thr Asp Ser 
    210                 215                 220                 


Glu Ser Phe Glu 
225             


<210>  16
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 233-460 K423S

<400>  16

Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro Ala Glu Cys Thr Thr 
1               5                   10                  15      


Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met Tyr Ala Ile Arg Pro 
            20                  25                  30          


Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp Val Ile Ser Gly Ser 
        35                  40                  45              


Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly Ser Gln Asn Phe Asn 
    50                  55                  60                  


Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly Arg Leu Asp Gly Glu 
65                  70                  75                  80  


Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile Val Lys Gln Ser Asn 
                85                  90                  95      


Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys Asp Asn Lys His Tyr 
            100                 105                 110         


Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu Thr Asn Tyr Thr Leu 
        115                 120                 125             


His Leu Val Ala Ile Thr Gly Asn Val Pro Asn Ala Ile Pro Glu Asn 
    130                 135                 140                 


Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys Ala Lys Gly His Phe 
145                 150                 155                 160 


Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp Trp His Asp Glu Cys 
                165                 170                 175     


Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys Pro Arg Ala Ser Ser 
            180                 185                 190         


Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys Ser Gln Asn Gly Arg 
        195                 200                 205             


Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile His Pro Thr Asp Ser 
    210                 215                 220                 


Glu Ser Phe Glu 
225             


<210>  17
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 241-460 K423Q

<400>  17

Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
1               5                   10                  15      


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            20                  25                  30          


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        35                  40                  45              


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    50                  55                  60                  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
65                  70                  75                  80  


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                85                  90                  95      


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            100                 105                 110         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        115                 120                 125             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    130                 135                 140                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
145                 150                 155                 160 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                165                 170                 175     


Tyr Asn Lys Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            180                 185                 190         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        195                 200                 205             


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    210                 215                 220 


<210>  18
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 241-460 K423S

<400>  18

Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
1               5                   10                  15      


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            20                  25                  30          


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        35                  40                  45              


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    50                  55                  60                  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
65                  70                  75                  80  


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                85                  90                  95      


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            100                 105                 110         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        115                 120                 125             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    130                 135                 140                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
145                 150                 155                 160 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                165                 170                 175     


Tyr Asn Lys Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            180                 185                 190         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        195                 200                 205             


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    210                 215                 220 


<210>  19
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 242-460 K423Q

<400>  19

Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
1               5                   10                  15      


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
            20                  25                  30          


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
        35                  40                  45              


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
    50                  55                  60                  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
65                  70                  75                  80  


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
                85                  90                  95      


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
            100                 105                 110         


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
        115                 120                 125             


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
    130                 135                 140                 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
145                 150                 155                 160 


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
                165                 170                 175     


Asn Lys Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
            180                 185                 190         


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
        195                 200                 205             


Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    210                 215                 


<210>  20
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 242-460 K423S

<400>  20

Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
1               5                   10                  15      


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
            20                  25                  30          


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
        35                  40                  45              


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
    50                  55                  60                  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
65                  70                  75                  80  


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
                85                  90                  95      


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
            100                 105                 110         


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
        115                 120                 125             


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
    130                 135                 140                 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
145                 150                 155                 160 


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
                165                 170                 175     


Asn Lys Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
            180                 185                 190         


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
        195                 200                 205             


Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    210                 215                 


<210>  21
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 225-455 K423Q

<400>  21

Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
1               5                   10                  15      


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
            20                  25                  30          


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
        35                  40                  45              


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
    50                  55                  60                  


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
65                  70                  75                  80  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
                85                  90                  95      


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
            100                 105                 110         


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
        115                 120                 125             


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
    130                 135                 140                 


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
145                 150                 155                 160 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
                165                 170                 175     


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
            180                 185                 190         


Tyr Asn Lys Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu 
        195                 200                 205             


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
    210                 215                 220                 


Met Leu Ile His Pro Thr Asp 
225                 230     


<210>  22
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 225-455 K423S

<400>  22

Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
1               5                   10                  15      


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
            20                  25                  30          


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
        35                  40                  45              


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
    50                  55                  60                  


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
65                  70                  75                  80  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
                85                  90                  95      


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
            100                 105                 110         


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
        115                 120                 125             


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
    130                 135                 140                 


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
145                 150                 155                 160 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
                165                 170                 175     


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
            180                 185                 190         


Tyr Asn Lys Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu 
        195                 200                 205             


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
    210                 215                 220                 


Met Leu Ile His Pro Thr Asp 
225                 230     


<210>  23
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 226-455 K423Q

<400>  23

Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly 
1               5                   10                  15      


Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
            20                  25                  30          


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
        35                  40                  45              


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
    50                  55                  60                  


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
65                  70                  75                  80  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
                85                  90                  95      


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
            100                 105                 110         


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
        115                 120                 125             


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
    130                 135                 140                 


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
145                 150                 155                 160 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
                165                 170                 175     


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
            180                 185                 190         


Asn Lys Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
        195                 200                 205             


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
    210                 215                 220                 


Leu Ile His Pro Thr Asp 
225                 230 


<210>  24
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 226-455 K423S

<400>  24

Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly 
1               5                   10                  15      


Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
            20                  25                  30          


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
        35                  40                  45              


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
    50                  55                  60                  


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
65                  70                  75                  80  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
                85                  90                  95      


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
            100                 105                 110         


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
        115                 120                 125             


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
    130                 135                 140                 


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
145                 150                 155                 160 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
                165                 170                 175     


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
            180                 185                 190         


Asn Lys Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
        195                 200                 205             


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
    210                 215                 220                 


Leu Ile His Pro Thr Asp 
225                 230 


<210>  25
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 228-455 K423Q

<400>  25

Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro 
1               5                   10                  15      


Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met 
            20                  25                  30          


Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp 
        35                  40                  45              


Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly 
    50                  55                  60                  


Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly 
65                  70                  75                  80  


Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile 
                85                  90                  95      


Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys 
            100                 105                 110         


Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu 
        115                 120                 125             


Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val Pro Asn 
    130                 135                 140                 


Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys 
145                 150                 155                 160 


Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp 
                165                 170                 175     


Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys 
            180                 185                 190         


Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys 
        195                 200                 205             


Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile 
    210                 215                 220                 


His Pro Thr Asp 
225             


<210>  26
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 228-455 K423S

<400>  26

Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro 
1               5                   10                  15      


Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met 
            20                  25                  30          


Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp 
        35                  40                  45              


Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly 
    50                  55                  60                  


Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly 
65                  70                  75                  80  


Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile 
                85                  90                  95      


Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys 
            100                 105                 110         


Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu 
        115                 120                 125             


Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val Pro Asn 
    130                 135                 140                 


Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys 
145                 150                 155                 160 


Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp 
                165                 170                 175     


Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys 
            180                 185                 190         


Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys 
        195                 200                 205             


Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile 
    210                 215                 220                 


His Pro Thr Asp 
225             


<210>  27
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 233-455 K423Q

<400>  27

Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro Ala Glu Cys Thr Thr 
1               5                   10                  15      


Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met Tyr Ala Ile Arg Pro 
            20                  25                  30          


Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp Val Ile Ser Gly Ser 
        35                  40                  45              


Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly Ser Gln Asn Phe Asn 
    50                  55                  60                  


Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly Arg Leu Asp Gly Glu 
65                  70                  75                  80  


Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile Val Lys Gln Ser Asn 
                85                  90                  95      


Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys Asp Asn Lys His Tyr 
            100                 105                 110         


Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu Thr Asn Tyr Thr Leu 
        115                 120                 125             


His Leu Val Ala Ile Thr Gly Asn Val Pro Asn Ala Ile Pro Glu Asn 
    130                 135                 140                 


Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys Ala Lys Gly His Phe 
145                 150                 155                 160 


Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp Trp His Asp Glu Cys 
                165                 170                 175     


Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys Pro Arg Ala Gln Ser 
            180                 185                 190         


Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys Ser Gln Asn Gly Arg 
        195                 200                 205             


Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile His Pro Thr Asp 
    210                 215                 220             


<210>  28
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 233-455 K423S

<400>  28

Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro Ala Glu Cys Thr Thr 
1               5                   10                  15      


Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met Tyr Ala Ile Arg Pro 
            20                  25                  30          


Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp Val Ile Ser Gly Ser 
        35                  40                  45              


Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly Ser Gln Asn Phe Asn 
    50                  55                  60                  


Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly Arg Leu Asp Gly Glu 
65                  70                  75                  80  


Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile Val Lys Gln Ser Asn 
                85                  90                  95      


Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys Asp Asn Lys His Tyr 
            100                 105                 110         


Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu Thr Asn Tyr Thr Leu 
        115                 120                 125             


His Leu Val Ala Ile Thr Gly Asn Val Pro Asn Ala Ile Pro Glu Asn 
    130                 135                 140                 


Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys Ala Lys Gly His Phe 
145                 150                 155                 160 


Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp Trp His Asp Glu Cys 
                165                 170                 175     


Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys Pro Arg Ala Ser Ser 
            180                 185                 190         


Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys Ser Gln Asn Gly Arg 
        195                 200                 205             


Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile His Pro Thr Asp 
    210                 215                 220             


<210>  29
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 241-455 K423Q

<400>  29

Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
1               5                   10                  15      


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            20                  25                  30          


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        35                  40                  45              


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    50                  55                  60                  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
65                  70                  75                  80  


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                85                  90                  95      


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            100                 105                 110         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        115                 120                 125             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    130                 135                 140                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
145                 150                 155                 160 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                165                 170                 175     


Tyr Asn Lys Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            180                 185                 190         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        195                 200                 205             


Met Leu Ile His Pro Thr Asp 
    210                 215 


<210>  30
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 241-455 K423S

<400>  30

Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
1               5                   10                  15      


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            20                  25                  30          


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        35                  40                  45              


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    50                  55                  60                  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
65                  70                  75                  80  


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                85                  90                  95      


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            100                 105                 110         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        115                 120                 125             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    130                 135                 140                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
145                 150                 155                 160 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                165                 170                 175     


Tyr Asn Lys Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            180                 185                 190         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        195                 200                 205             


Met Leu Ile His Pro Thr Asp 
    210                 215 


<210>  31
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 242-455 K423Q

<400>  31

Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
1               5                   10                  15      


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
            20                  25                  30          


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
        35                  40                  45              


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
    50                  55                  60                  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
65                  70                  75                  80  


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
                85                  90                  95      


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
            100                 105                 110         


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
        115                 120                 125             


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
    130                 135                 140                 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
145                 150                 155                 160 


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
                165                 170                 175     


Asn Lys Pro Arg Ala Gln Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
            180                 185                 190         


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
        195                 200                 205             


Leu Ile His Pro Thr Asp 
    210                 


<210>  32
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 242-455 K423S

<400>  32

Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
1               5                   10                  15      


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
            20                  25                  30          


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
        35                  40                  45              


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
    50                  55                  60                  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
65                  70                  75                  80  


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
                85                  90                  95      


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
            100                 105                 110         


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
        115                 120                 125             


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
    130                 135                 140                 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
145                 150                 155                 160 


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
                165                 170                 175     


Asn Lys Pro Arg Ala Ser Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
            180                 185                 190         


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
        195                 200                 205             


Leu Ile His Pro Thr Asp 
    210                 


<210>  33
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 201-460 K423del

<400>  33

Ile Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro 
1               5                   10                  15      


Arg Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His 
            20                  25                  30          


Asp Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His 
        35                  40                  45              


Thr Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His 
    50                  55                  60                  


Val Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His 
65                  70                  75                  80  


Arg Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys 
                85                  90                  95      


Tyr Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys 
            100                 105                 110         


Ile Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu 
        115                 120                 125             


Glu Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu 
    130                 135                 140                 


Gly Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly 
145                 150                 155                 160 


Asn Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr 
                165                 170                 175     


Trp Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser 
            180                 185                 190         


Gly Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly 
        195                 200                 205             


Lys Tyr Asn Lys Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu 
    210                 215                 220                 


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
225                 230                 235                 240 


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
                245                 250         


<210>  34
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 225-460 K423del

<400>  34

Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
1               5                   10                  15      


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
            20                  25                  30          


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
        35                  40                  45              


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
    50                  55                  60                  


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
65                  70                  75                  80  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
                85                  90                  95      


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
            100                 105                 110         


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
        115                 120                 125             


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
    130                 135                 140                 


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
145                 150                 155                 160 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
                165                 170                 175     


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
            180                 185                 190         


Tyr Asn Lys Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
        195                 200                 205             


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
    210                 215                 220                 


Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230                 235 


<210>  35
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 226-460 K423del

<400>  35

Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly 
1               5                   10                  15      


Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
            20                  25                  30          


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
        35                  40                  45              


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
    50                  55                  60                  


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
65                  70                  75                  80  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
                85                  90                  95      


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
            100                 105                 110         


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
        115                 120                 125             


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
    130                 135                 140                 


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
145                 150                 155                 160 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
                165                 170                 175     


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
            180                 185                 190         


Asn Lys Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp 
        195                 200                 205             


Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu 
    210                 215                 220                 


Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230                 


<210>  36
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 228-460 K423del

<400>  36

Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro 
1               5                   10                  15      


Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met 
            20                  25                  30          


Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp 
        35                  40                  45              


Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly 
    50                  55                  60                  


Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly 
65                  70                  75                  80  


Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile 
                85                  90                  95      


Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys 
            100                 105                 110         


Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu 
        115                 120                 125             


Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val Pro Asn 
    130                 135                 140                 


Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys 
145                 150                 155                 160 


Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp 
                165                 170                 175     


Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys 
            180                 185                 190         


Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys Ser 
        195                 200                 205             


Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile His 
    210                 215                 220                 


Pro Thr Asp Ser Glu Ser Phe Glu 
225                 230         


<210>  37
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 233-460 K423del

<400>  37

Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro Ala Glu Cys Thr Thr 
1               5                   10                  15      


Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met Tyr Ala Ile Arg Pro 
            20                  25                  30          


Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp Val Ile Ser Gly Ser 
        35                  40                  45              


Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly Ser Gln Asn Phe Asn 
    50                  55                  60                  


Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly Arg Leu Asp Gly Glu 
65                  70                  75                  80  


Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile Val Lys Gln Ser Asn 
                85                  90                  95      


Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys Asp Asn Lys His Tyr 
            100                 105                 110         


Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu Thr Asn Tyr Thr Leu 
        115                 120                 125             


His Leu Val Ala Ile Thr Gly Asn Val Pro Asn Ala Ile Pro Glu Asn 
    130                 135                 140                 


Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys Ala Lys Gly His Phe 
145                 150                 155                 160 


Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp Trp His Asp Glu Cys 
                165                 170                 175     


Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys Pro Arg Ala Ser Lys 
            180                 185                 190         


Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys Ser Gln Asn Gly Arg Leu 
        195                 200                 205             


Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile His Pro Thr Asp Ser Glu 
    210                 215                 220                 


Ser Phe Glu 
225         


<210>  38
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 241-460 K423del

<400>  38

Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
1               5                   10                  15      


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            20                  25                  30          


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        35                  40                  45              


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    50                  55                  60                  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
65                  70                  75                  80  


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                85                  90                  95      


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            100                 105                 110         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        115                 120                 125             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    130                 135                 140                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
145                 150                 155                 160 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                165                 170                 175     


Tyr Asn Lys Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
            180                 185                 190         


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
        195                 200                 205             


Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    210                 215                 


<210>  39
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 242-460 K423del

<400>  39

Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
1               5                   10                  15      


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
            20                  25                  30          


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
        35                  40                  45              


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
    50                  55                  60                  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
65                  70                  75                  80  


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
                85                  90                  95      


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
            100                 105                 110         


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
        115                 120                 125             


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
    130                 135                 140                 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
145                 150                 155                 160 


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
                165                 170                 175     


Asn Lys Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp 
            180                 185                 190         


Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu 
        195                 200                 205             


Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    210                 215             


<210>  40
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 225-455 K423del

<400>  40

Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
1               5                   10                  15      


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
            20                  25                  30          


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
        35                  40                  45              


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
    50                  55                  60                  


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
65                  70                  75                  80  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
                85                  90                  95      


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
            100                 105                 110         


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
        115                 120                 125             


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
    130                 135                 140                 


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
145                 150                 155                 160 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
                165                 170                 175     


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
            180                 185                 190         


Tyr Asn Lys Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
        195                 200                 205             


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
    210                 215                 220                 


Leu Ile His Pro Thr Asp 
225                 230 


<210>  41
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 226-455 K423del

<400>  41

Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly 
1               5                   10                  15      


Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
            20                  25                  30          


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
        35                  40                  45              


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
    50                  55                  60                  


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
65                  70                  75                  80  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
                85                  90                  95      


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
            100                 105                 110         


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
        115                 120                 125             


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
    130                 135                 140                 


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
145                 150                 155                 160 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
                165                 170                 175     


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
            180                 185                 190         


Asn Lys Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp 
        195                 200                 205             


Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu 
    210                 215                 220                 


Ile His Pro Thr Asp 
225                 


<210>  42
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 228-455 K423del

<400>  42

Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro 
1               5                   10                  15      


Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met 
            20                  25                  30          


Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp 
        35                  40                  45              


Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly 
    50                  55                  60                  


Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly 
65                  70                  75                  80  


Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile 
                85                  90                  95      


Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys 
            100                 105                 110         


Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu 
        115                 120                 125             


Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val Pro Asn 
    130                 135                 140                 


Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys 
145                 150                 155                 160 


Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp 
                165                 170                 175     


Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys 
            180                 185                 190         


Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys Ser 
        195                 200                 205             


Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu Ile His 
    210                 215                 220                 


Pro Thr Asp 
225         


<210>  43
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 233-455 K423del

<400>  43

Glu Ile Arg Asn Val Lys His Asp Gly Ile Pro Ala Glu Cys Thr Thr 
1               5                   10                  15      


Ile Tyr Asn Arg Gly Glu His Thr Ser Gly Met Tyr Ala Ile Arg Pro 
            20                  25                  30          


Ser Asn Ser Gln Val Phe His Val Tyr Cys Asp Val Ile Ser Gly Ser 
        35                  40                  45              


Pro Trp Thr Leu Ile Gln His Arg Ile Asp Gly Ser Gln Asn Phe Asn 
    50                  55                  60                  


Glu Thr Trp Glu Asn Tyr Lys Tyr Gly Phe Gly Arg Leu Asp Gly Glu 
65                  70                  75                  80  


Phe Trp Leu Gly Leu Glu Lys Ile Tyr Ser Ile Val Lys Gln Ser Asn 
                85                  90                  95      


Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp Lys Asp Asn Lys His Tyr 
            100                 105                 110         


Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His Glu Thr Asn Tyr Thr Leu 
        115                 120                 125             


His Leu Val Ala Ile Thr Gly Asn Val Pro Asn Ala Ile Pro Glu Asn 
    130                 135                 140                 


Lys Asp Leu Val Phe Ser Thr Trp Asp His Lys Ala Lys Gly His Phe 
145                 150                 155                 160 


Asn Cys Pro Glu Gly Tyr Ser Gly Gly Trp Trp Trp His Asp Glu Cys 
                165                 170                 175     


Gly Glu Asn Asn Leu Asn Gly Lys Tyr Asn Lys Pro Arg Ala Ser Lys 
            180                 185                 190         


Pro Glu Arg Arg Arg Gly Leu Ser Trp Lys Ser Gln Asn Gly Arg Leu 
        195                 200                 205             


Tyr Ser Ile Lys Ser Thr Lys 
    210                 215 


<210>  44
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 241-455 K423del

<400>  44

Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
1               5                   10                  15      


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            20                  25                  30          


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        35                  40                  45              


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    50                  55                  60                  


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
65                  70                  75                  80  


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                85                  90                  95      


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            100                 105                 110         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        115                 120                 125             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    130                 135                 140                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
145                 150                 155                 160 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                165                 170                 175     


Tyr Asn Lys Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser 
            180                 185                 190         


Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met 
        195                 200                 205             


Leu Ile His Pro Thr Asp 
    210                 


<210>  45
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL3 242-455 K423del

<400>  45

Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr Ser 
1               5                   10                  15      


Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val Tyr 
            20                  25                  30          


Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg Ile 
        35                  40                  45              


Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr Gly 
    50                  55                  60                  


Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile Tyr 
65                  70                  75                  80  


Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp 
                85                  90                  95      


Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn 
            100                 105                 110         


His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val 
        115                 120                 125             


Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp 
    130                 135                 140                 


His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Gly 
145                 150                 155                 160 


Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys Tyr 
                165                 170                 175     


Asn Lys Pro Arg Ala Ser Lys Pro Glu Arg Arg Arg Gly Leu Ser Trp 
            180                 185                 190         


Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys Met Leu 
        195                 200                 205             


Ile His Pro Thr Asp 
    210             


