                         SEQUENCE LISTING

<110>  ST. ANNA KINDERKREBSFORSCHUNG
       UNIVERSITT FR BODENKULTUR WIEN
 
<120>  A group of chimeric antigen receptors (CARs)

<130>  R 75556

<150>  EP 18198850.2
<151>  2018 10 05

<150>  EP 19175974.5
<151>  2019 05 22

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  1

Gly Gly Ser Gly 
1               


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  2

Gly Gly Ser Gly Gly 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  3

Gly Ser Gly Ser Gly 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  4

Gly Ser Gly Gly Gly 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  5

Gly Gly Gly Ser Gly 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  6

Gly Ser Ser Ser Gly 
1               5   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  7

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  8

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  9

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  10
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  10

Met Ala Ser Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
1               5                   10                  15      


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
            20                  25                  30          


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
        35                  40                  45              


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
    50                  55                  60                  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
65                  70                  75                  80  


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
                85                  90                  95      


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105                 110     


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  11

Asp Ala Phe Gln Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp 
1               5                   10                  15      


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  12

Ser Pro Gly Ser Arg Glu Trp Phe Lys Asp Met Leu Ser 
1               5                   10              


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  13

Pro Arg Gln Gly Ser Ile Leu Tyr Ser Met Leu Thr Ser Ala Lys Gln 
1               5                   10                  15      


Thr 
    


<210>  14
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  14

Pro Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp 
1               5                   10                  15      


Asp Pro Ser Asp Val 
            20      


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  15

Ser Ser Lys Gly Val Leu Trp Arg Met Leu Ala Glu Pro Val Ser Arg 
1               5                   10                  15      


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  16

Ser Arg Thr Leu Gln Leu Asp Trp Gly Thr Leu Tyr Trp Ser Arg 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  17

Ser Ser Asn His Gln Ser Ser Arg Leu Ile Glu Leu Leu Ser Arg 
1               5                   10                  15  


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  18

Arg Leu Thr Lys Thr Asn Pro Ile Leu Tyr Tyr Met Leu Gln Lys Gly 
1               5                   10                  15      


Gly Asn Ser Val Ala 
            20      


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  19

Asn Leu Leu Glu Arg Arg Thr Val Leu Gln Leu Leu Leu Gly Asn Pro 
1               5                   10                  15      


Thr Lys Gly Arg Val 
            20      


<210>  20
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  20

Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp Ile 
1               5                   10                  15      


Ser Lys Ile Lys Trp Val Ile Arg Trp Gly Gln His Ile Ala Phe Lys 
            20                  25                  30          


Tyr Asp Glu Gly Gly Gly Ala Ala Gly Tyr Gly Trp Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln 
    50                  55                  60      


<210>  21
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  21

Ala Ala Val Lys Leu Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp Ile 
1               5                   10                  15      


Ser Lys Ile Lys Tyr Val Asp Arg Ala Gly Gln Phe Ile Trp Phe Glu 
            20                  25                  30          


Tyr Asp Glu Gly Gly Gly Ala Leu Gly Thr Gly Trp Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln 
    50                  55                  60      


<210>  22
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  22

Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp Ile 
1               5                   10                  15      


Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe Gly 
            20                  25                  30          


Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln 
    50                  55                  60      


<210>  23
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  23

Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp Ile 
1               5                   10                  15      


Ser Lys Ile Met Tyr Val Ile Arg Ala Gly Gln Arg Ile Ala Phe Gly 
            20                  25                  30          


Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln 
    50                  55                  60      


<210>  24
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  24

Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp Ile 
1               5                   10                  15      


Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Ala Ile Ala Phe Gly 
            20                  25                  30          


Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln 
    50                  55                  60      


<210>  25
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  25

Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp Ile 
1               5                   10                  15      


Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe Ala 
            20                  25                  30          


Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln 
    50                  55                  60      


<210>  26
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  26

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  27
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  27

Val Asp Asn Lys Phe Asn Lys Glu Ala Arg Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  28
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  28

Val Asp Asn Lys Phe Asn Lys Glu Leu Ala Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  29
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  29

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Ala Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  30
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  30

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Ala Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  31
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  31

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Ala Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  32
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  32

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Ala Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  33
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  33

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Ala Thr Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  34
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  34

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Ala Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  35
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  35

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ala Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  36
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  36

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Ala Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  37
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  37

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Arg Ala Phe Ile Ala 
            20                  25                  30          


Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  38
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  38

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Lys Leu Ala Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  39
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  39

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Gly Gly Ser 
            20                  25                  30          


Ala Ala Val Lys Leu Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp Ile 
        35                  40                  45              


Ser Lys Ile Lys Tyr Val Asp Arg Ala Gly Gln Phe Ile Trp Phe Glu 
    50                  55                  60                  


Tyr Asp Glu Gly Gly Gly Ala Leu Gly Thr Gly Trp Val Ser Glu Lys 
65                  70                  75                  80  


Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Thr Thr Thr 
                85                  90                  95      


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            100                 105                 110         


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        115                 120                 125             


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    130                 135                 140                 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
145                 150                 155                 160 


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
                165                 170                 175     


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
            180                 185                 190         


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
        195                 200                 205             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
    210                 215                 220                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
225                 230                 235                 240 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                245                 250                 255     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            260                 265                 270         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        275                 280                 285             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    290                 295                 300                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315     


<210>  40
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  40

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Ala Val Lys Leu Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Lys Tyr Val Asp Arg Ala Gly Gln Phe Ile Trp Phe 
        35                  40                  45              


Glu Tyr Asp Glu Gly Gly Gly Ala Leu Gly Thr Gly Trp Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Thr Thr 
65                  70                  75                  80  


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
                85                  90                  95      


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
            100                 105                 110         


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
        115                 120                 125             


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
    130                 135                 140                 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    290                 295                 300     


<210>  41
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  41

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Ala Val Lys Leu Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Lys Tyr Val Asp Arg Ala Gly Gln Phe Ile Trp Phe 
        35                  40                  45              


Glu Tyr Asp Glu Gly Gly Gly Ala Leu Gly Thr Gly Trp Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Thr Thr Thr Pro Ala Pro Arg Pro 
                85                  90                  95      


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            100                 105                 110         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        115                 120                 125             


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    130                 135                 140                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
145                 150                 155                 160 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                165                 170                 175     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            180                 185                 190         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        195                 200                 205             


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    210                 215                 220                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
225                 230                 235                 240 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                245                 250                 255     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            260                 265                 270         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        275                 280                 285             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    290                 295                 300                 


Met Gln Ala Leu Pro Pro Arg 
305                 310     


<210>  42
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  42

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu 
                85                  90                  95      


Asp Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            100                 105                 110         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        115                 120                 125             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    130                 135                 140                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
145                 150                 155                 160 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                165                 170                 175     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            180                 185                 190         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        195                 200                 205             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    210                 215                 220                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
225                 230                 235                 240 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                245                 250                 255     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            260                 265                 270         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        275                 280                 285             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    290                 295                 300                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
305                 310                 315                 320 


Arg 
    


<210>  43
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  43

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
    210                 215                 220                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
225                 230                 235                 240 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                245                 250                 255     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            260                 265                 270         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        275                 280                 285             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    290                 295                 300                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315                 320 


<210>  44
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  44

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
    210                 215                 220                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
225                 230                 235                 240 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                245                 250                 255     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            260                 265                 270         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        275                 280                 285             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    290                 295                 300                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315                 320 


<210>  45
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  45

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser His His His His His His Thr Thr 
                85                  90                  95      


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            100                 105                 110         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        115                 120                 125             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    130                 135                 140                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
145                 150                 155                 160 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                165                 170                 175     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            180                 185                 190         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        195                 200                 205             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
    210                 215                 220                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
225                 230                 235                 240 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                245                 250                 255     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            260                 265                 270         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        275                 280                 285             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315         


<210>  46
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  46

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Ser Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Gly Val Gln Val Glu 
    210                 215                 220                 


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
225                 230                 235                 240 


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
                245                 250                 255     


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
            260                 265                 270         


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
        275                 280                 285             


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
    290                 295                 300                 


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
305                 310                 315                 320 


Glu Leu Leu Lys Leu Glu Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


<210>  47
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  47

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    210                 215                 220                 


Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
225                 230                 235                 240 


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
                245                 250                 255     


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
            260                 265                 270         


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
        275                 280                 285             


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
                325                 330                 335     


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            340                 345                 350         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        355                 360                 365             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
385                 390                 395                 400 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                405                 410                 415     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            420                 425                 430         


Met Gln Ala Leu Pro Pro Arg 
        435                 


<210>  48
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  48

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
                85                  90                  95      


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
            100                 105                 110         


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly 
        115                 120                 125             


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile 
    130                 135                 140                 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
145                 150                 155                 160 


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
                165                 170                 175     


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            180                 185                 190         


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ser 
        195                 200                 205             


Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Gly Val Gln Val Glu Thr 
    210                 215                 220                 


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
225                 230                 235                 240 


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
                245                 250                 255     


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
            260                 265                 270         


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
        275                 280                 285             


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
    290                 295                 300                 


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
305                 310                 315                 320 


Leu Leu Lys Leu Glu Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg 
                325                 330                 335     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            340                 345                 350         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        355                 360                 365             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    370                 375                 380                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
385                 390                 395                 400 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                405                 410                 415     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            420                 425                 430         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445         


<210>  49
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  49

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Gly Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Ser Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Gly Val Gln Val Glu 
    210                 215                 220                 


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
225                 230                 235                 240 


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
                245                 250                 255     


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
            260                 265                 270         


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
        275                 280                 285             


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
    290                 295                 300                 


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
305                 310                 315                 320 


Glu Leu Leu Lys Leu Glu Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


<210>  50
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  50

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Gly Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
                85                  90                  95      


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
            100                 105                 110         


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly 
        115                 120                 125             


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile 
    130                 135                 140                 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
145                 150                 155                 160 


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
                165                 170                 175     


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            180                 185                 190         


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ser 
        195                 200                 205             


Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Gly Val Gln Val Glu Thr 
    210                 215                 220                 


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
225                 230                 235                 240 


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
                245                 250                 255     


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
            260                 265                 270         


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
        275                 280                 285             


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
    290                 295                 300                 


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
305                 310                 315                 320 


Leu Leu Lys Leu Glu Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg 
                325                 330                 335     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            340                 345                 350         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        355                 360                 365             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    370                 375                 380                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
385                 390                 395                 400 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                405                 410                 415     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            420                 425                 430         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445         


<210>  51
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  51

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Gly Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    210                 215                 220                 


Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
225                 230                 235                 240 


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
                245                 250                 255     


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
            260                 265                 270         


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
        275                 280                 285             


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
                325                 330                 335     


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            340                 345                 350         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        355                 360                 365             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
385                 390                 395                 400 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                405                 410                 415     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            420                 425                 430         


Met Gln Ala Leu Pro Pro Arg 
        435                 


<210>  52
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  52

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Trp Glu 
            20                  25                  30          


Ile Gln Ala Leu Pro Asn Leu Ala Trp Thr Gln Ser Arg Ala Phe Ile 
        35                  40                  45              


Arg Lys Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
    50                  55                  60                  


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser His His His His His His Thr Thr Thr Pro Ala 
                85                  90                  95      


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
            100                 105                 110         


Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr 
        115                 120                 125             


Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
    130                 135                 140                 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
145                 150                 155                 160 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                165                 170                 175     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            180                 185                 190         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ser Arg Gly Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Ser Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
    210                 215                 220                 


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
225                 230                 235                 240 


Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn 
                245                 250                 255     


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
            260                 265                 270         


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
        275                 280                 285             


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
    290                 295                 300                 


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
305                 310                 315                 320 


Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440         


<210>  53
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  53

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Lys Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met Arg Arg Arg His Ile Val Arg Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Met Gly Val Gln Val Glu Thr Ile Ser Pro 
    370                 375                 380                 


Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His 
385                 390                 395                 400 


Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp 
                405                 410                 415     


Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg 
            420                 425                 430         


Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys 
        435                 440                 445             


Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly 
    450                 455                 460                 


Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys 
465                 470                 475                 480 


Leu Glu 
        


<210>  54
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  54

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Lys Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met Arg Arg Arg His Ile Val Arg Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Arg Gly Val Gln Val Glu Thr Ile Ser Pro 
    370                 375                 380                 


Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His 
385                 390                 395                 400 


Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp 
                405                 410                 415     


Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg 
            420                 425                 430         


Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys 
        435                 440                 445             


Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly 
    450                 455                 460                 


Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys 
465                 470                 475                 480 


Leu Glu 
        


<210>  55
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  55

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Ala Arg Val Cys Tyr Gly Leu Gly Met Glu 
            20                  25                  30          


His Leu Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe 
        35                  40                  45              


Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser 
    50                  55                  60                  


Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln 
65                  70                  75                  80  


Leu Gln Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile 
                85                  90                  95      


Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu 
            100                 105                 110         


Gln Val Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr 
        115                 120                 125             


Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu 
    130                 135                 140                 


Leu Gly Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe 
145                 150                 155                 160 


Val His Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala 
                165                 170                 175     


Leu Leu His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly 
            180                 185                 190         


Leu Ala Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly 
        195                 200                 205             


Pro Thr Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys 
    210                 215                 220                 


Val Glu Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn 
225                 230                 235                 240 


Ala Arg His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly 
                245                 250                 255     


Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala 
            260                 265                 270         


His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val 
        275                 280                 285             


Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu 
    290                 295                 300                 


Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp 
305                 310                 315                 320 


Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr 
                325                 330                 335     


Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly 
            340                 345                 350         


Val Val Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Gly 
        355                 360                 365             


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ile 
    370                 375                 380                 


Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu 
385                 390                 395                 400 


Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro 
                405                 410                 415     


Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser 
            420                 425                 430         


Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys 
        435                 440                 445             


Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp 
    450                 455                 460                 


Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
465                 470                 475     


<210>  56
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  56

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys Thr Thr Thr Pro Ala Pro 
145                 150                 155                 160 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                165                 170                 175     


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            180                 185                 190         


Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        195                 200                 205             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
    210                 215                 220             


<210>  57
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  57

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
        35                  40                  45              


Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ser Arg Trp Gly Gly Asp Gly Phe Val Ala Met Asp Val Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Asn Trp Ser His Pro 
    130                 135                 140                 


Gln Phe Glu Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
145                 150                 155                 160 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg 
                165                 170                 175     


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser 
            180                 185                 190         


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
        195                 200                 205             


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
    210                 215                 220                 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
225                 230                 235                 240 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                245                 250                 255     


Cys Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Gly Val 
            260                 265                 270         


Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg 
        275                 280                 285             


Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys 
    290                 295                 300                 


Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu 
305                 310                 315                 320 


Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met 
                325                 330                 335     


Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr 
            340                 345                 350         


Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val 
        355                 360                 365             


Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly Ser Gly Ser Gly 
    370                 375                 380                 


Ser Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  58
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  58

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  59
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  59

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
                165                 170                 175     


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Val Ala Met Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  60
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  60

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
                165                 170                 175     


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Val Ala Met Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  61
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  61

Met Ser His His His His His His Gly Ser Ala Thr Val Lys Phe Thr 
1               5                   10                  15      


Tyr Gln Gly Glu Glu Lys Gln Val Asp Ile Ser Lys Ile Met Tyr Val 
            20                  25                  30          


Ile Arg Gly Gly Gln Arg Ile Ala Phe Gly Tyr Asp Glu Gly Asp Gly 
        35                  40                  45              


Ala Trp Gly Asp Gly Ile Val Ser Glu Lys Asp Ala Pro Lys Glu Leu 
    50                  55                  60                  


Leu Gln Met Leu Glu Lys Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly 
65                  70                  75                  80  


Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
                85                  90                  95      


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg 
            100                 105                 110         


Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe 
        115                 120                 125             


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    130                 135                 140                 


Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
145                 150                 155                 160 


Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                165                 170                 175     


Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala 
            180                 185                 190         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        195                 200                 205             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
    210                 215                 220                 


Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys 
225                 230                 235                 240 


Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly 
                245                 250                 255     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            260                 265                 270         


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val 
        275                 280                 285             


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
    290                 295                 300                 


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
305                 310                 315                 320 


<210>  62
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  62

Met Gly His His His His His His Gly Ser Val Asp Asn Lys Phe Asn 
1               5                   10                  15      


Lys Glu Leu Arg Gln Ala Tyr Trp Glu Ile Gln Ala Leu Pro Asn Leu 
            20                  25                  30          


Ala Trp Thr Gln Ser Arg Ala Phe Ile Arg Lys Leu Tyr Asp Asp Pro 
        35                  40                  45              


Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala 
    50                  55                  60                  


Gln Ala Pro Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Val 
65                  70                  75                  80  


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
                85                  90                  95      


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
            100                 105                 110         


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        115                 120                 125             


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
    130                 135                 140                 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg His 
145                 150                 155                 160 


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
                165                 170                 175     


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
            180                 185                 190         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        195                 200                 205             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
    210                 215                 220                 


Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile 
225                 230                 235                 240 


Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln 
                245                 250                 255     


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
            260                 265                 270         


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys 
        275                 280                 285             


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
    290                 295                 300                 


Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
305                 310                 315         


<210>  63
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  63

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            100                 105                 110         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        115                 120                 125             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
145                 150                 155                 160 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                165                 170                 175     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            180                 185                 190         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        195                 200                 205             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    210                 215                 220                 


Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu 
225                 230                 235                 240 


Arg Phe Tyr Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Asp Ile Phe 
            260                 265                 270         


Pro Asn Gly Leu Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        275                 280                 285             


Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Pro Tyr Pro Ser Trp 
    290                 295                 300                 


Leu Met Gly Thr Arg Phe Ser Cys Ser Val Met His Glu Ala Leu His 
305                 310                 315                 320 


Asn His Tyr Thr Gln Lys His Leu Glu Tyr Gln Trp Pro Thr 
                325                 330                 


<210>  64
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  64

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Asn Trp 
65                  70                  75                  80  


Ser His Pro Gln Phe Glu Lys Glu Pro Lys Ser Pro Asp Lys Thr His 
                85                  90                  95      


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            100                 105                 110         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        115                 120                 125             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    130                 135                 140                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
145                 150                 155                 160 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                165                 170                 175     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            180                 185                 190         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        195                 200                 205             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro 
    210                 215                 220                 


Pro Ser Arg Asp Glu Leu Arg Phe Tyr Gln Val Ser Leu Thr Cys Leu 
225                 230                 235                 240 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                245                 250                 255     


Gly Gln Pro Asp Ile Phe Pro Asn Gly Leu Asn Tyr Lys Thr Thr Pro 
            260                 265                 270         


Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr 
        275                 280                 285             


Val Pro Tyr Pro Ser Trp Leu Met Gly Thr Arg Phe Ser Cys Ser Val 
    290                 295                 300                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys His Leu Glu Tyr 
305                 310                 315                 320 


Gln Trp Pro Thr 
                


<210>  65
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  65

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Lys Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val 
                245                 250                 255     


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro 
            260                 265                 270         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        275                 280                 285             


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    290                 295                 300                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
305                 310                 315                 320 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                325                 330                 335     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
            340                 345                 350         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        355                 360                 365             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    370                 375                 380                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
385                 390                 395                 400 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                405                 410                 415     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            420                 425                 430         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 


<210>  66
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  66

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Lys Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
                245                 250                 255     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            260                 265                 270         


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        275                 280                 285             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    290                 295                 300                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
305                 310                 315                 320 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                325                 330                 335     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            340                 345                 350         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        355                 360                 365             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    370                 375                 380                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
385                 390                 395                 400 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                405                 410                 415     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430         


<210>  67
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  67

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    210                 215                 220                 


Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
225                 230                 235                 240 


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
                245                 250                 255     


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
            260                 265                 270         


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
        275                 280                 285             


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ile Leu Trp 
                325                 330                 335     


His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
            340                 345                 350         


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
        355                 360                 365             


Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
    370                 375                 380                 


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
385                 390                 395                 400 


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu 
                405                 410                 415     


Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Gly Ser Gly Ser Gly Ser 
            420                 425                 430         


Gly Ser Ser Leu 
        435     


<210>  68
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  68

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    210                 215                 220                 


Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
225                 230                 235                 240 


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
                245                 250                 255     


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
            260                 265                 270         


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
        275                 280                 285             


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Ser Leu Met Gly Val Gln Val Glu Thr Ile Ser 
                325                 330                 335     


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
            340                 345                 350         


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg 
        355                 360                 365             


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
    370                 375                 380                 


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
385                 390                 395                 400 


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
                405                 410                 415     


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
            420                 425                 430         


Lys Leu Glu 
        435 


<210>  69
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  69

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Phe Trp 
    130                 135                 140                 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
145                 150                 155                 160 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
                165                 170                 175     


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
            180                 185                 190         


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
        195                 200                 205             


Arg Ser Ser Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Gly Val Gln 
    210                 215                 220                 


Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly 
225                 230                 235                 240 


Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys 
                245                 250                 255     


Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly 
            260                 265                 270         


Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser 
        275                 280                 285             


Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly 
    290                 295                 300                 


Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe 
305                 310                 315                 320 


Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
            340                 345                 350         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        355                 360                 365             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    370                 375                 380                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                405                 410                 415     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            420                 425                 430         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        435                 440                 445             


Pro Arg 
    450 


<210>  70
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  70

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Phe Glu 
    130                 135                 140                 


Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
145                 150                 155                 160 


Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser 
                165                 170                 175     


Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr 
            180                 185                 190         


Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Thr Ser Ser Arg Gly 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Ser Met Gly Val Gln Val Glu Thr Ile Ser 
    210                 215                 220                 


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
225                 230                 235                 240 


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg 
                245                 250                 255     


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
            260                 265                 270         


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
        275                 280                 285             


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
    290                 295                 300                 


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
305                 310                 315                 320 


Lys Leu Glu Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys 
                325                 330                 335     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
            340                 345                 350         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        355                 360                 365             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    370                 375                 380                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
385                 390                 395                 400 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                405                 410                 415     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            420                 425                 430         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445 


<210>  71
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  71

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Ala Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
                165                 170                 175     


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
            180                 185                 190         


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Ser Arg Gly Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Ser Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
    210                 215                 220                 


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
225                 230                 235                 240 


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
                245                 250                 255     


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
            260                 265                 270         


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
        275                 280                 285             


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
    290                 295                 300                 


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
305                 310                 315                 320 


Glu Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys Phe Ser 
                325                 330                 335     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            340                 345                 350         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        355                 360                 365             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    370                 375                 380                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
385                 390                 395                 400 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                405                 410                 415     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            420                 425                 430         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440             


<210>  72
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  72

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Ala Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Gly Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
    210                 215                 220                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
225                 230                 235                 240 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                245                 250                 255     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            260                 265                 270         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        275                 280                 285             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    290                 295                 300                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315                 320 


<210>  73
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  73

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Ala Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Gly Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
    210                 215                 220                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
225                 230                 235                 240 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                245                 250                 255     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            260                 265                 270         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        275                 280                 285             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    290                 295                 300                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315                 320 


<210>  74
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  74

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Gly Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
    210                 215                 220                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
225                 230                 235                 240 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                245                 250                 255     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            260                 265                 270         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        275                 280                 285             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    290                 295                 300                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315                 320 


<210>  75
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  75

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Ala Thr Val Lys Phe Thr Tyr Gln Gly Glu Glu Lys Gln Val Asp 
            20                  25                  30          


Ile Ser Lys Ile Met Tyr Val Ile Arg Gly Gly Gln Arg Ile Ala Phe 
        35                  40                  45              


Gly Tyr Asp Glu Gly Asp Gly Ala Trp Gly Asp Gly Ile Val Ser Glu 
    50                  55                  60                  


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
                85                  90                  95      


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            100                 105                 110         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
        115                 120                 125             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr 
    130                 135                 140                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
145                 150                 155                 160 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                165                 170                 175     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            180                 185                 190         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 205             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
    210                 215                 220                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
225                 230                 235                 240 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                245                 250                 255     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            260                 265                 270         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        275                 280                 285             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    290                 295                 300                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315                 320 


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  76

Asn Trp Ser His Pro Gln Phe Glu Lys 
1               5                   


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  77

His His His His His His 
1               5       


