                         SEQUENCE LISTING

<110>  Inserm
 
<120>  USE OF EGFR INHIBITORS FOR THE KERATODERMAS

<130>  BIO18398 BODEMER / MC

<160>  1     

<170>  PatentIn version 3.3

<210>  1
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Ala His Pro Lys Glu Met Val Pro Leu Met Gly Lys Arg Val 
1               5                   10                  15      


Ala Ala Pro Ser Gly Asn Pro Ala Ile Leu Pro Glu Lys Arg Pro Ala 
            20                  25                  30          


Glu Ile Thr Pro Thr Lys Lys Ser Ala His Phe Phe Leu Glu Ile Glu 
        35                  40                  45              


Gly Phe Glu Pro Asn Pro Thr Val Ala Lys Thr Ser Pro Pro Val Phe 
    50                  55                  60                  


Ser Lys Pro Met Asp Ser Asn Ile Arg Gln Cys Ile Ser Gly Asn Cys 
65                  70                  75                  80  


Asp Asp Met Asp Ser Pro Gln Ser Pro Gln Asp Asp Val Thr Glu Thr 
                85                  90                  95      


Pro Ser Asn Pro Asn Ser Pro Ser Ala Gln Leu Ala Lys Glu Glu Gln 
            100                 105                 110         


Arg Arg Lys Lys Arg Arg Leu Lys Lys Arg Ile Phe Ala Ala Val Ser 
        115                 120                 125             


Glu Gly Cys Val Glu Glu Leu Val Glu Leu Leu Val Glu Leu Gln Glu 
    130                 135                 140                 


Leu Cys Arg Arg Arg His Asp Glu Asp Val Pro Asp Phe Leu Met His 
145                 150                 155                 160 


Lys Leu Thr Ala Ser Asp Thr Gly Lys Thr Cys Leu Met Lys Ala Leu 
                165                 170                 175     


Leu Asn Ile Asn Pro Asn Thr Lys Glu Ile Val Arg Ile Leu Leu Ala 
            180                 185                 190         


Phe Ala Glu Glu Asn Asp Ile Leu Gly Arg Phe Ile Asn Ala Glu Tyr 
        195                 200                 205             


Thr Glu Glu Ala Tyr Glu Gly Gln Thr Ala Leu Asn Ile Ala Ile Glu 
    210                 215                 220                 


Arg Arg Gln Gly Asp Ile Ala Ala Leu Leu Ile Ala Ala Gly Ala Asp 
225                 230                 235                 240 


Val Asn Ala His Ala Lys Gly Ala Phe Phe Asn Pro Lys Tyr Gln His 
                245                 250                 255     


Glu Gly Phe Tyr Phe Gly Glu Thr Pro Leu Ala Leu Ala Ala Cys Thr 
            260                 265                 270         


Asn Gln Pro Glu Ile Val Gln Leu Leu Met Glu His Glu Gln Thr Asp 
        275                 280                 285             


Ile Thr Ser Arg Asp Ser Arg Gly Asn Asn Ile Leu His Ala Leu Val 
    290                 295                 300                 


Thr Val Ala Glu Asp Phe Lys Thr Gln Asn Asp Phe Val Lys Arg Met 
305                 310                 315                 320 


Tyr Asp Met Ile Leu Leu Arg Ser Gly Asn Trp Glu Leu Glu Thr Thr 
                325                 330                 335     


Arg Asn Asn Asp Gly Leu Thr Pro Leu Gln Leu Ala Ala Lys Met Gly 
            340                 345                 350         


Lys Ala Glu Ile Leu Lys Tyr Ile Leu Ser Arg Glu Ile Lys Glu Lys 
        355                 360                 365             


Arg Leu Arg Ser Leu Ser Arg Lys Phe Thr Asp Trp Ala Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Ser Leu Tyr Asp Leu Thr Asn Val Asp Thr Thr Thr Asp 
385                 390                 395                 400 


Asn Ser Val Leu Glu Ile Thr Val Tyr Asn Thr Asn Ile Asp Asn Arg 
                405                 410                 415     


His Glu Met Leu Thr Leu Glu Pro Leu His Thr Leu Leu His Met Lys 
            420                 425                 430         


Trp Lys Lys Phe Ala Lys His Met Phe Phe Leu Ser Phe Cys Phe Tyr 
        435                 440                 445             


Phe Phe Tyr Asn Ile Thr Leu Thr Leu Val Ser Tyr Tyr Arg Pro Arg 
    450                 455                 460                 


Glu Glu Glu Ala Ile Pro His Pro Leu Ala Leu Thr His Lys Met Gly 
465                 470                 475                 480 


Trp Leu Gln Leu Leu Gly Arg Met Phe Val Leu Ile Trp Ala Met Cys 
                485                 490                 495     


Ile Ser Val Lys Glu Gly Ile Ala Ile Phe Leu Leu Arg Pro Ser Asp 
            500                 505                 510         


Leu Gln Ser Ile Leu Ser Asp Ala Trp Phe His Phe Val Phe Phe Ile 
        515                 520                 525             


Gln Ala Val Leu Val Ile Leu Ser Val Phe Leu Tyr Leu Phe Ala Tyr 
    530                 535                 540                 


Lys Glu Tyr Leu Ala Cys Leu Val Leu Ala Met Ala Leu Gly Trp Ala 
545                 550                 555                 560 


Asn Met Leu Tyr Tyr Thr Arg Gly Phe Gln Ser Met Gly Met Tyr Ser 
                565                 570                 575     


Val Met Ile Gln Lys Val Ile Leu His Asp Val Leu Lys Phe Leu Phe 
            580                 585                 590         


Val Tyr Ile Val Phe Leu Leu Gly Phe Gly Val Ala Leu Ala Ser Leu 
        595                 600                 605             


Ile Glu Lys Cys Pro Lys Asp Asn Lys Asp Cys Ser Ser Tyr Gly Ser 
    610                 615                 620                 


Phe Ser Asp Ala Val Leu Glu Leu Phe Lys Leu Thr Ile Gly Leu Gly 
625                 630                 635                 640 


Asp Leu Asn Ile Gln Gln Asn Ser Lys Tyr Pro Ile Leu Phe Leu Phe 
                645                 650                 655     


Leu Leu Ile Thr Tyr Val Ile Leu Thr Phe Val Leu Leu Leu Asn Met 
            660                 665                 670         


Leu Ile Ala Leu Met Gly Glu Thr Val Glu Asn Val Ser Lys Glu Ser 
        675                 680                 685             


Glu Arg Ile Trp Arg Leu Gln Arg Ala Arg Thr Ile Leu Glu Phe Glu 
    690                 695                 700                 


Lys Met Leu Pro Glu Trp Leu Arg Ser Arg Phe Arg Met Gly Glu Leu 
705                 710                 715                 720 


Cys Lys Val Ala Glu Asp Asp Phe Arg Leu Cys Leu Arg Ile Asn Glu 
                725                 730                 735     


Val Lys Trp Thr Glu Trp Lys Thr His Val Ser Phe Leu Asn Glu Asp 
            740                 745                 750         


Pro Gly Pro Val Arg Arg Thr Asp Phe Asn Lys Ile Gln Asp Ser Ser 
        755                 760                 765             


Arg Asn Asn Ser Lys Thr Thr Leu Asn Ala Phe Glu Glu Val Glu Glu 
    770                 775                 780                 


Phe Pro Glu Thr Ser Val 
785                 790 


