               SEQUENCE LISTING

<110> Thrombosis and Coagulation AB

<120> Protein Assay

<130> THRBG/P70583PC

<140> PCT/EP2019/076801
<141> 2019-10-03

<150> SE - 1851200-4 
<151> 2018-10-04

<160> 5

<170> BiSSAP 1.3.6

<210> 1
<211> 2196
<212> PRT
<213> Homo sapiens


<400> 1
Ala Gln Leu Arg Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser 
1               5                   10                  15      
Tyr Arg Pro Glu Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser 
            20                  25                  30          
Phe Lys Lys Ile Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu 
        35                  40                  45              
Lys Pro Gln Ser Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala 
    50                  55                  60                  
Glu Val Gly Asp Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys 
65                  70                  75                  80  
Pro Leu Ser Ile His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu 
                85                  90                  95      
Gly Ala Ser Tyr Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp 
            100                 105                 110         
Ala Val Ala Pro Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu 
        115                 120                 125             
Asp Ser Gly Pro Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr 
    130                 135                 140                 
Tyr Ser His Glu Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly 
145                 150                 155                 160 
Pro Leu Leu Ile Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln 
                165                 170                 175     
Lys Thr Phe Asp Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu 
            180                 185                 190         
Ser Lys Ser Trp Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly 
        195                 200                 205             
Tyr Val Asn Gly Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His 
    210                 215                 220                 
Ile Ser Trp His Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser 
225                 230                 235                 240 
Ile His Phe Asn Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser 
                245                 250                 255     
Ala Ile Thr Leu Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val 
            260                 265                 270         
Gly Pro Glu Gly Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu 
        275                 280                 285             
Gln Ala Gly Met Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys 
    290                 295                 300                 
Thr Arg Asn Leu Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys 
305                 310                 315                 320 
Arg Trp Glu Tyr Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala 
                325                 330                 335     
Pro Val Ile Pro Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu 
            340                 345                 350         
Asp Asn Phe Ser Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr 
        355                 360                 365             
Thr Gln Tyr Glu Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn 
    370                 375                 380                 
Met Lys Glu Asp Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg 
385                 390                 395                 400 
Asp Thr Leu Lys Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser 
                405                 410                 415     
Ile Tyr Pro His Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn 
            420                 425                 430         
Ser Ser Phe Thr Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln 
        435                 440                 445             
Pro Gly Glu Thr Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu 
    450                 455                 460                 
Pro Thr Glu Asn Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp 
465                 470                 475                 480 
Val Asp Ile Met Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu 
                485                 490                 495     
Ile Cys Lys Ser Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala 
            500                 505                 510         
Asp Ile Glu Gln Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser 
        515                 520                 525             
Trp Tyr Leu Glu Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu 
    530                 535                 540                 
Val Lys Arg Asp Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr 
545                 550                 555                 560 
Ile Asn Gly Tyr Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe 
                565                 570                 575     
Asp Asp Thr Val Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu 
            580                 585                 590         
Ile Leu Thr Ile His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg 
        595                 600                 605             
His Glu Asp Thr Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr 
    610                 615                 620                 
Val Thr Met Asp Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser 
625                 630                 635                 640 
Ser Pro Arg Ser Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys 
                645                 650                 655     
Ile Pro Asp Asp Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu 
            660                 665                 670         
Ser Thr Val Met Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu 
        675                 680                 685             
Asp Glu Glu Ser Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala 
    690                 695                 700                 
Ala Leu Gly Ile Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu Glu 
705                 710                 715                 720 
Glu Glu Phe Asn Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu Phe 
                725                 730                 735     
Val Ser Ser Asn Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser Pro 
            740                 745                 750         
Ser Asn Ile Ser Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln Lys 
        755                 760                 765             
Ala Pro Ser His Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg His 
    770                 775                 780                 
Leu Ile Gly Lys Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His Ser 
785                 790                 795                 800 
Ser Pro Tyr Ser Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp Val 
                805                 810                 815     
Thr Gly Ile Arg Leu Leu Ser Leu Gly Ala Gly Glu Phe Lys Ser Gln 
            820                 825                 830         
Glu His Ala Lys His Lys Gly Pro Lys Val Glu Arg Asp Gln Ala Ala 
        835                 840                 845             
Lys His Arg Phe Ser Trp Met Lys Leu Leu Ala His Lys Val Gly Arg 
    850                 855                 860                 
His Leu Ser Gln Asp Thr Gly Ser Pro Ser Gly Met Arg Pro Trp Glu 
865                 870                 875                 880 
Asp Leu Pro Ser Gln Asp Thr Gly Ser Pro Ser Arg Met Arg Pro Trp 
                885                 890                 895     
Lys Asp Pro Pro Ser Asp Leu Leu Leu Leu Lys Gln Ser Asn Ser Ser 
            900                 905                 910         
Lys Ile Leu Val Gly Arg Trp His Leu Ala Ser Glu Lys Gly Ser Tyr 
        915                 920                 925             
Glu Ile Ile Gln Asp Thr Asp Glu Asp Thr Ala Val Asn Asn Trp Leu 
    930                 935                 940                 
Ile Ser Pro Gln Asn Ala Ser Arg Ala Trp Gly Glu Ser Thr Pro Leu 
945                 950                 955                 960 
Ala Asn Lys Pro Gly Lys Gln Ser Gly His Pro Lys Phe Pro Arg Val 
                965                 970                 975     
Arg His Lys Ser Leu Gln Val Arg Gln Asp Gly Gly Lys Ser Arg Leu 
            980                 985                 990         
Lys Lys Ser Gln Phe Leu Ile Lys Thr Arg Lys Lys Lys Lys Glu Lys 
        995                 1000                1005            
His Thr His His Ala Pro Leu Ser Pro Arg Thr Phe His Pro Leu Arg 
    1010                1015                1020                
Ser Glu Ala Tyr Asn Thr Phe Ser Glu Arg Arg Leu Lys His Ser Leu 
1025                1030                1035                1040
Val Leu His Lys Ser Asn Glu Thr Ser Leu Pro Thr Asp Leu Asn Gln 
                1045                1050                1055    
Thr Leu Pro Ser Met Asp Phe Gly Trp Ile Ala Ser Leu Pro Asp His 
            1060                1065                1070        
Asn Gln Asn Ser Ser Asn Asp Thr Gly Gln Ala Ser Cys Pro Pro Gly 
        1075                1080                1085            
Leu Tyr Gln Thr Val Pro Pro Glu Glu His Tyr Gln Thr Phe Pro Ile 
    1090                1095                1100                
Gln Asp Pro Asp Gln Met His Ser Thr Ser Asp Pro Ser His Arg Ser 
1105                1110                1115                1120
Ser Ser Pro Glu Leu Ser Glu Met Leu Glu Tyr Asp Arg Ser His Lys 
                1125                1130                1135    
Ser Phe Pro Thr Asp Ile Ser Gln Met Ser Pro Ser Ser Glu His Glu 
            1140                1145                1150        
Val Trp Gln Thr Val Ile Ser Pro Asp Leu Ser Gln Val Thr Leu Ser 
        1155                1160                1165            
Pro Glu Leu Ser Gln Thr Asn Leu Ser Pro Asp Leu Ser His Thr Thr 
    1170                1175                1180                
Leu Ser Pro Glu Leu Ile Gln Arg Asn Leu Ser Pro Ala Leu Gly Gln 
1185                1190                1195                1200
Met Pro Ile Ser Pro Asp Leu Ser His Thr Thr Leu Ser Pro Asp Leu 
                1205                1210                1215    
Ser His Thr Thr Leu Ser Leu Asp Leu Ser Gln Thr Asn Leu Ser Pro 
            1220                1225                1230        
Glu Leu Ser Gln Thr Asn Leu Ser Pro Ala Leu Gly Gln Met Pro Leu 
        1235                1240                1245            
Ser Pro Asp Leu Ser His Thr Thr Leu Ser Leu Asp Phe Ser Gln Thr 
    1250                1255                1260                
Asn Leu Ser Pro Glu Leu Ser His Met Thr Leu Ser Pro Glu Leu Ser 
1265                1270                1275                1280
Gln Thr Asn Leu Ser Pro Ala Leu Gly Gln Met Pro Ile Ser Pro Asp 
                1285                1290                1295    
Leu Ser His Thr Thr Leu Ser Leu Asp Phe Ser Gln Thr Asn Leu Ser 
            1300                1305                1310        
Pro Glu Leu Ser Gln Thr Asn Leu Ser Pro Ala Leu Gly Gln Met Pro 
        1315                1320                1325            
Leu Ser Pro Asp Pro Ser His Thr Thr Leu Ser Leu Asp Leu Ser Gln 
    1330                1335                1340                
Thr Asn Leu Ser Pro Glu Leu Ser Gln Thr Asn Leu Ser Pro Asp Leu 
1345                1350                1355                1360
Ser Glu Met Pro Leu Phe Ala Asp Leu Ser Gln Ile Pro Leu Thr Pro 
                1365                1370                1375    
Asp Leu Asp Gln Met Thr Leu Ser Pro Asp Leu Gly Glu Thr Asp Leu 
            1380                1385                1390        
Ser Pro Asn Phe Gly Gln Met Ser Leu Ser Pro Asp Leu Ser Gln Val 
        1395                1400                1405            
Thr Leu Ser Pro Asp Ile Ser Asp Thr Thr Leu Leu Pro Asp Leu Ser 
    1410                1415                1420                
Gln Ile Ser Pro Pro Pro Asp Leu Asp Gln Ile Phe Tyr Pro Ser Glu 
1425                1430                1435                1440
Ser Ser Gln Ser Leu Leu Leu Gln Glu Phe Asn Glu Ser Phe Pro Tyr 
                1445                1450                1455    
Pro Asp Leu Gly Gln Met Pro Ser Pro Ser Ser Pro Thr Leu Asn Asp 
            1460                1465                1470        
Thr Phe Leu Ser Lys Glu Phe Asn Pro Leu Val Ile Val Gly Leu Ser 
        1475                1480                1485            
Lys Asp Gly Thr Asp Tyr Ile Glu Ile Ile Pro Lys Glu Glu Val Gln 
    1490                1495                1500                
Ser Ser Glu Asp Asp Tyr Ala Glu Ile Asp Tyr Val Pro Tyr Asp Asp 
1505                1510                1515                1520
Pro Tyr Lys Thr Asp Val Arg Thr Asn Ile Asn Ser Ser Arg Asp Pro 
                1525                1530                1535    
Asp Asn Ile Ala Ala Trp Tyr Leu Arg Ser Asn Asn Gly Asn Arg Arg 
            1540                1545                1550        
Asn Tyr Tyr Ile Ala Ala Glu Glu Ile Ser Trp Asp Tyr Ser Glu Phe 
        1555                1560                1565            
Val Gln Arg Glu Thr Asp Ile Glu Asp Ser Asp Asp Ile Pro Glu Asp 
    1570                1575                1580                
Thr Thr Tyr Lys Lys Val Val Phe Arg Lys Tyr Leu Asp Ser Thr Phe 
1585                1590                1595                1600
Thr Lys Arg Asp Pro Arg Gly Glu Tyr Glu Glu His Leu Gly Ile Leu 
                1605                1610                1615    
Gly Pro Ile Ile Arg Ala Glu Val Asp Asp Val Ile Gln Val Arg Phe 
            1620                1625                1630        
Lys Asn Leu Ala Ser Arg Pro Tyr Ser Leu His Ala His Gly Leu Ser 
        1635                1640                1645            
Tyr Glu Lys Ser Ser Glu Gly Lys Thr Tyr Glu Asp Asp Ser Pro Glu 
    1650                1655                1660                
Trp Phe Lys Glu Asp Asn Ala Val Gln Pro Asn Ser Ser Tyr Thr Tyr 
1665                1670                1675                1680
Val Trp His Ala Thr Glu Arg Ser Gly Pro Glu Ser Pro Gly Ser Ala 
                1685                1690                1695    
Cys Arg Ala Trp Ala Tyr Tyr Ser Ala Val Asn Pro Glu Lys Asp Ile 
            1700                1705                1710        
His Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Gln Lys Gly Ile Leu 
        1715                1720                1725            
His Lys Asp Ser Asn Met Pro Met Asp Met Arg Glu Phe Val Leu Leu 
    1730                1735                1740                
Phe Met Thr Phe Asp Glu Lys Lys Ser Trp Tyr Tyr Glu Lys Lys Ser 
1745                1750                1755                1760
Arg Ser Ser Trp Arg Leu Thr Ser Ser Glu Met Lys Lys Ser His Glu 
                1765                1770                1775    
Phe His Ala Ile Asn Gly Met Ile Tyr Ser Leu Pro Gly Leu Lys Met 
            1780                1785                1790        
Tyr Glu Gln Glu Trp Val Arg Leu His Leu Leu Asn Ile Gly Gly Ser 
        1795                1800                1805            
Gln Asp Ile His Val Val His Phe His Gly Gln Thr Leu Leu Glu Asn 
    1810                1815                1820                
Gly Asn Lys Gln His Gln Leu Gly Val Trp Pro Leu Leu Pro Gly Ser 
1825                1830                1835                1840
Phe Lys Thr Leu Glu Met Lys Ala Ser Lys Pro Gly Trp Trp Leu Leu 
                1845                1850                1855    
Asn Thr Glu Val Gly Glu Asn Gln Arg Ala Gly Met Gln Thr Pro Phe 
            1860                1865                1870        
Leu Ile Met Asp Arg Asp Cys Arg Met Pro Met Gly Leu Ser Thr Gly 
        1875                1880                1885            
Ile Ile Ser Asp Ser Gln Ile Lys Ala Ser Glu Phe Leu Gly Tyr Trp 
    1890                1895                1900                
Glu Pro Arg Leu Ala Arg Leu Asn Asn Gly Gly Ser Tyr Asn Ala Trp 
1905                1910                1915                1920
Ser Val Glu Lys Leu Ala Ala Glu Phe Ala Ser Lys Pro Trp Ile Gln 
                1925                1930                1935    
Val Asp Met Gln Lys Glu Val Ile Ile Thr Gly Ile Gln Thr Gln Gly 
            1940                1945                1950        
Ala Lys His Tyr Leu Lys Ser Cys Tyr Thr Thr Glu Phe Tyr Val Ala 
        1955                1960                1965            
Tyr Ser Ser Asn Gln Ile Asn Trp Gln Ile Phe Lys Gly Asn Ser Thr 
    1970                1975                1980                
Arg Asn Val Met Tyr Phe Asn Gly Asn Ser Asp Ala Ser Thr Ile Lys 
1985                1990                1995                2000
Glu Asn Gln Phe Asp Pro Pro Ile Val Ala Arg Tyr Ile Arg Ile Ser 
                2005                2010                2015    
Pro Thr Arg Ala Tyr Asn Arg Pro Thr Leu Arg Leu Glu Leu Gln Gly 
            2020                2025                2030        
Cys Glu Val Asn Gly Cys Ser Thr Pro Leu Gly Met Glu Asn Gly Lys 
        2035                2040                2045            
Ile Glu Asn Lys Gln Ile Thr Ala Ser Ser Phe Lys Lys Ser Trp Trp 
    2050                2055                2060                
Gly Asp Tyr Trp Glu Pro Phe Arg Ala Arg Leu Asn Ala Gln Gly Arg 
2065                2070                2075                2080
Val Asn Ala Trp Gln Ala Lys Ala Asn Asn Asn Lys Gln Trp Leu Glu 
                2085                2090                2095    
Ile Asp Leu Leu Lys Ile Lys Lys Ile Thr Ala Ile Ile Thr Gln Gly 
            2100                2105                2110        
Cys Lys Ser Leu Ser Ser Glu Met Tyr Val Lys Ser Tyr Thr Ile His 
        2115                2120                2125            
Tyr Ser Glu Gln Gly Val Glu Trp Lys Pro Tyr Arg Leu Lys Ser Ser 
    2130                2135                2140                
Met Val Asp Lys Ile Phe Glu Gly Asn Thr Asn Thr Lys Gly His Val 
2145                2150                2155                2160
Lys Asn Phe Phe Asn Pro Pro Ile Ile Ser Arg Phe Ile Arg Val Ile 
                2165                2170                2175    
Pro Lys Thr Trp Asn Gln Ser Ile Ala Leu Arg Leu Glu Leu Phe Gly 
            2180                2185                2190        
Cys Asp Ile Tyr 
        2195    

<210> 2
<211> 1494
<212> PRT
<213> Homo sapiens


<400> 2
Ala Gln Leu Arg Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser 
1               5                   10                  15      
Tyr Arg Pro Glu Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser 
            20                  25                  30          
Phe Lys Lys Ile Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu 
        35                  40                  45              
Lys Pro Gln Ser Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala 
    50                  55                  60                  
Glu Val Gly Asp Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys 
65                  70                  75                  80  
Pro Leu Ser Ile His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu 
                85                  90                  95      
Gly Ala Ser Tyr Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp 
            100                 105                 110         
Ala Val Ala Pro Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu 
        115                 120                 125             
Asp Ser Gly Pro Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr 
    130                 135                 140                 
Tyr Ser His Glu Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly 
145                 150                 155                 160 
Pro Leu Leu Ile Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln 
                165                 170                 175     
Lys Thr Phe Asp Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu 
            180                 185                 190         
Ser Lys Ser Trp Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly 
        195                 200                 205             
Tyr Val Asn Gly Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His 
    210                 215                 220                 
Ile Ser Trp His Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser 
225                 230                 235                 240 
Ile His Phe Asn Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser 
                245                 250                 255     
Ala Ile Thr Leu Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val 
            260                 265                 270         
Gly Pro Glu Gly Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu 
        275                 280                 285             
Gln Ala Gly Met Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys 
    290                 295                 300                 
Thr Arg Asn Leu Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys 
305                 310                 315                 320 
Arg Trp Glu Tyr Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala 
                325                 330                 335     
Pro Val Ile Pro Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu 
            340                 345                 350         
Asp Asn Phe Ser Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr 
        355                 360                 365             
Thr Gln Tyr Glu Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn 
    370                 375                 380                 
Met Lys Glu Asp Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg 
385                 390                 395                 400 
Asp Thr Leu Lys Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser 
                405                 410                 415     
Ile Tyr Pro His Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn 
            420                 425                 430         
Ser Ser Phe Thr Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln 
        435                 440                 445             
Pro Gly Glu Thr Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu 
    450                 455                 460                 
Pro Thr Glu Asn Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp 
465                 470                 475                 480 
Val Asp Ile Met Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu 
                485                 490                 495     
Ile Cys Lys Ser Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala 
            500                 505                 510         
Asp Ile Glu Gln Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser 
        515                 520                 525             
Trp Tyr Leu Glu Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu 
    530                 535                 540                 
Val Lys Arg Asp Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr 
545                 550                 555                 560 
Ile Asn Gly Tyr Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe 
                565                 570                 575     
Asp Asp Thr Val Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu 
            580                 585                 590         
Ile Leu Thr Ile His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg 
        595                 600                 605             
His Glu Asp Thr Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr 
    610                 615                 620                 
Val Thr Met Asp Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser 
625                 630                 635                 640 
Ser Pro Arg Ser Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys 
                645                 650                 655     
Ile Pro Asp Asp Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu 
            660                 665                 670         
Ser Thr Val Met Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu 
        675                 680                 685             
Asp Glu Glu Ser Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala 
    690                 695                 700                 
Ala Leu Gly Ile Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu Glu 
705                 710                 715                 720 
Glu Glu Phe Asn Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu Phe 
                725                 730                 735     
Val Ser Ser Asn Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser Pro 
            740                 745                 750         
Ser Asn Ile Asn Leu Gly Gln Met Pro Ser Pro Ser Ser Pro Thr Leu 
        755                 760                 765             
Asn Asp Thr Phe Leu Ser Lys Glu Phe Asn Pro Leu Val Ile Val Gly 
    770                 775                 780                 
Leu Ser Lys Asp Gly Thr Asp Tyr Ile Glu Ile Ile Pro Lys Glu Glu 
785                 790                 795                 800 
Val Gln Ser Ser Glu Asp Asp Tyr Ala Glu Ile Asp Tyr Val Pro Tyr 
                805                 810                 815     
Asp Asp Pro Tyr Lys Thr Asp Val Arg Thr Asn Ile Asn Ser Ser Arg 
            820                 825                 830         
Asp Pro Asp Asn Ile Ala Ala Trp Tyr Leu Arg Ser Asn Asn Gly Asn 
        835                 840                 845             
Arg Arg Asn Tyr Tyr Ile Ala Ala Glu Glu Ile Ser Trp Asp Tyr Ser 
    850                 855                 860                 
Glu Phe Val Gln Arg Glu Thr Asp Ile Glu Asp Ser Asp Asp Ile Pro 
865                 870                 875                 880 
Glu Asp Thr Thr Tyr Lys Lys Val Val Phe Arg Lys Tyr Leu Asp Ser 
                885                 890                 895     
Thr Phe Thr Lys Arg Asp Pro Arg Gly Glu Tyr Glu Glu His Leu Gly 
            900                 905                 910         
Ile Leu Gly Pro Ile Ile Arg Ala Glu Val Asp Asp Val Ile Gln Val 
        915                 920                 925             
Arg Phe Lys Asn Leu Ala Ser Arg Pro Tyr Ser Leu His Ala His Gly 
    930                 935                 940                 
Leu Ser Tyr Glu Lys Ser Ser Glu Gly Lys Thr Tyr Glu Asp Asp Ser 
945                 950                 955                 960 
Pro Glu Trp Phe Lys Glu Asp Asn Ala Val Gln Pro Asn Ser Ser Tyr 
                965                 970                 975     
Thr Tyr Val Trp His Ala Thr Glu Arg Ser Gly Pro Glu Ser Pro Gly 
            980                 985                 990         
Ser Ala Cys Arg Ala Trp Ala Tyr Tyr Ser Ala Val Asn Pro Glu Lys 
        995                 1000                1005            
Asp Ile His Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Gln Lys Gly 
    1010                1015                1020                
Ile Leu His Lys Asp Ser Asn Met Pro Met Asp Met Arg Glu Phe Val 
1025                1030                1035                1040
Leu Leu Phe Met Thr Phe Asp Glu Lys Lys Ser Trp Tyr Tyr Glu Lys 
                1045                1050                1055    
Lys Ser Arg Ser Ser Trp Arg Leu Thr Ser Ser Glu Met Lys Lys Ser 
            1060                1065                1070        
His Glu Phe His Ala Ile Asn Gly Met Ile Tyr Ser Leu Pro Gly Leu 
        1075                1080                1085            
Lys Met Tyr Glu Gln Glu Trp Val Arg Leu His Leu Leu Asn Ile Gly 
    1090                1095                1100                
Gly Ser Gln Asp Ile His Val Val His Phe His Gly Gln Thr Leu Leu 
1105                1110                1115                1120
Glu Asn Gly Asn Lys Gln His Gln Leu Gly Val Trp Pro Leu Leu Pro 
                1125                1130                1135    
Gly Ser Phe Lys Thr Leu Glu Met Lys Ala Ser Lys Pro Gly Trp Trp 
            1140                1145                1150        
Leu Leu Asn Thr Glu Val Gly Glu Asn Gln Arg Ala Gly Met Gln Thr 
        1155                1160                1165            
Pro Phe Leu Ile Met Asp Arg Asp Cys Arg Met Pro Met Gly Leu Ser 
    1170                1175                1180                
Thr Gly Ile Ile Ser Asp Ser Gln Ile Lys Ala Ser Glu Phe Leu Gly 
1185                1190                1195                1200
Tyr Trp Glu Pro Arg Leu Ala Arg Leu Asn Asn Gly Gly Ser Tyr Asn 
                1205                1210                1215    
Ala Trp Ser Val Glu Lys Leu Ala Ala Glu Phe Ala Ser Lys Pro Trp 
            1220                1225                1230        
Ile Gln Val Asp Met Gln Lys Glu Val Ile Ile Thr Gly Ile Gln Thr 
        1235                1240                1245            
Gln Gly Ala Lys His Tyr Leu Lys Ser Cys Tyr Thr Thr Glu Phe Tyr 
    1250                1255                1260                
Val Ala Tyr Ser Ser Asn Gln Ile Asn Trp Gln Ile Phe Lys Gly Asn 
1265                1270                1275                1280
Ser Thr Arg Asn Val Met Tyr Phe Asn Gly Asn Ser Asp Ala Ser Thr 
                1285                1290                1295    
Ile Lys Glu Asn Gln Phe Asp Pro Pro Ile Val Ala Arg Tyr Ile Arg 
            1300                1305                1310        
Ile Ser Pro Thr Arg Ala Tyr Asn Arg Pro Thr Leu Arg Leu Glu Leu 
        1315                1320                1325            
Gln Gly Cys Glu Val Asn Gly Cys Ser Thr Pro Leu Gly Met Glu Asn 
    1330                1335                1340                
Gly Lys Ile Glu Asn Lys Gln Ile Thr Ala Ser Ser Phe Lys Lys Ser 
1345                1350                1355                1360
Trp Trp Gly Asp Tyr Trp Glu Pro Phe Arg Ala Arg Leu Asn Ala Gln 
                1365                1370                1375    
Gly Arg Val Asn Ala Trp Gln Ala Lys Ala Asn Asn Asn Lys Gln Trp 
            1380                1385                1390        
Leu Glu Ile Asp Leu Leu Lys Ile Lys Lys Ile Thr Ala Ile Ile Thr 
        1395                1400                1405            
Gln Gly Cys Lys Ser Leu Ser Ser Glu Met Tyr Val Lys Ser Tyr Thr 
    1410                1415                1420                
Ile His Tyr Ser Glu Gln Gly Val Glu Trp Lys Pro Tyr Arg Leu Lys 
1425                1430                1435                1440
Ser Ser Met Val Asp Lys Ile Phe Glu Gly Asn Thr Asn Thr Lys Gly 
                1445                1450                1455    
His Val Lys Asn Phe Phe Asn Pro Pro Ile Ile Ser Arg Phe Ile Arg 
            1460                1465                1470        
Val Ile Pro Lys Thr Trp Asn Gln Ser Ile Ala Leu Arg Leu Glu Leu 
        1475                1480                1485            
Phe Gly Cys Asp Ile Tyr 
    1490                

<210> 3
<211> 1515
<212> PRT
<213> Homo sapiens


<400> 3
Ala Gln Leu Arg Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser 
1               5                   10                  15      
Tyr Arg Pro Glu Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser 
            20                  25                  30          
Phe Lys Lys Ile Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu 
        35                  40                  45              
Lys Pro Gln Ser Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala 
    50                  55                  60                  
Glu Val Gly Asp Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys 
65                  70                  75                  80  
Pro Leu Ser Ile His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu 
                85                  90                  95      
Gly Ala Ser Tyr Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp 
            100                 105                 110         
Ala Val Ala Pro Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu 
        115                 120                 125             
Asp Ser Gly Pro Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr 
    130                 135                 140                 
Tyr Ser His Glu Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly 
145                 150                 155                 160 
Pro Leu Leu Ile Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln 
                165                 170                 175     
Lys Thr Phe Asp Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu 
            180                 185                 190         
Ser Lys Ser Trp Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly 
        195                 200                 205             
Tyr Val Asn Gly Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His 
    210                 215                 220                 
Ile Ser Trp His Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser 
225                 230                 235                 240 
Ile His Phe Asn Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser 
                245                 250                 255     
Ala Ile Thr Leu Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val 
            260                 265                 270         
Gly Pro Glu Gly Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu 
        275                 280                 285             
Gln Ala Gly Met Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys 
    290                 295                 300                 
Thr Arg Asn Leu Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys 
305                 310                 315                 320 
Arg Trp Glu Tyr Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala 
                325                 330                 335     
Pro Val Ile Pro Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu 
            340                 345                 350         
Asp Asn Phe Ser Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr 
        355                 360                 365             
Thr Gln Tyr Glu Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn 
    370                 375                 380                 
Met Lys Glu Asp Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg 
385                 390                 395                 400 
Asp Thr Leu Lys Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser 
                405                 410                 415     
Ile Tyr Pro His Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn 
            420                 425                 430         
Ser Ser Phe Thr Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln 
        435                 440                 445             
Pro Gly Glu Thr Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu 
    450                 455                 460                 
Pro Thr Glu Asn Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp 
465                 470                 475                 480 
Val Asp Ile Met Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu 
                485                 490                 495     
Ile Cys Lys Ser Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala 
            500                 505                 510         
Asp Ile Glu Gln Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser 
        515                 520                 525             
Trp Tyr Leu Glu Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu 
    530                 535                 540                 
Val Lys Arg Asp Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr 
545                 550                 555                 560 
Ile Asn Gly Tyr Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe 
                565                 570                 575     
Asp Asp Thr Val Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu 
            580                 585                 590         
Ile Leu Thr Ile His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg 
        595                 600                 605             
His Glu Asp Thr Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr 
    610                 615                 620                 
Val Thr Met Asp Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser 
625                 630                 635                 640 
Ser Pro Arg Ser Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys 
                645                 650                 655     
Ile Pro Asp Asp Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu 
            660                 665                 670         
Ser Thr Val Met Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu 
        675                 680                 685             
Asp Glu Glu Ser Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala 
    690                 695                 700                 
Ala Leu Gly Ile Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu Glu 
705                 710                 715                 720 
Glu Glu Phe Asn Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu Phe 
                725                 730                 735     
Val Ser Ser Asn Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser Pro 
            740                 745                 750         
Ser Asn Ile Ser Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln Lys 
        755                 760                 765             
Ala Pro Ser His Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg His 
    770                 775                 780                 
Leu Ile Gly Lys Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His Ser 
785                 790                 795                 800 
Ser Pro Tyr Ser Glu Asp Pro Ile Glu Asp Thr Asp Tyr Ile Glu Ile 
                805                 810                 815     
Ile Pro Lys Glu Glu Val Gln Ser Ser Glu Asp Asp Tyr Ala Glu Ile 
            820                 825                 830         
Asp Tyr Val Pro Tyr Asp Asp Pro Tyr Lys Thr Asp Val Arg Thr Asn 
        835                 840                 845             
Ile Asn Ser Ser Arg Asp Pro Asp Asn Ile Ala Ala Trp Tyr Leu Arg 
    850                 855                 860                 
Ser Asn Asn Gly Asn Arg Arg Asn Tyr Tyr Ile Ala Ala Glu Glu Ile 
865                 870                 875                 880 
Ser Trp Asp Tyr Ser Glu Phe Val Gln Arg Glu Thr Asp Ile Glu Asp 
                885                 890                 895     
Ser Asp Asp Ile Pro Glu Asp Thr Thr Tyr Lys Lys Val Val Phe Arg 
            900                 905                 910         
Lys Tyr Leu Asp Ser Thr Phe Thr Lys Arg Asp Pro Arg Gly Glu Tyr 
        915                 920                 925             
Glu Glu His Leu Gly Ile Leu Gly Pro Ile Ile Arg Ala Glu Val Asp 
    930                 935                 940                 
Asp Val Ile Gln Val Arg Phe Lys Asn Leu Ala Ser Arg Pro Tyr Ser 
945                 950                 955                 960 
Leu His Ala His Gly Leu Ser Tyr Glu Lys Ser Ser Glu Gly Lys Thr 
                965                 970                 975     
Tyr Glu Asp Asp Ser Pro Glu Trp Phe Lys Glu Asp Asn Ala Val Gln 
            980                 985                 990         
Pro Asn Ser Ser Tyr Thr Tyr Val Trp His Ala Thr Glu Arg Ser Gly 
        995                 1000                1005            
Pro Glu Ser Pro Gly Ser Ala Cys Arg Ala Trp Ala Tyr Tyr Ser Ala 
    1010                1015                1020                
Val Asn Pro Glu Lys Asp Ile His Ser Gly Leu Ile Gly Pro Leu Leu 
1025                1030                1035                1040
Ile Cys Gln Lys Gly Ile Leu His Lys Asp Ser Asn Met Pro Val Asp 
                1045                1050                1055    
Met Arg Glu Phe Val Leu Leu Phe Met Thr Phe Asp Glu Lys Lys Ser 
            1060                1065                1070        
Trp Tyr Tyr Glu Lys Lys Ser Arg Ser Ser Trp Arg Leu Thr Ser Ser 
        1075                1080                1085            
Glu Met Lys Lys Ser His Glu Phe His Ala Ile Asn Gly Met Ile Tyr 
    1090                1095                1100                
Ser Leu Pro Gly Leu Lys Met Tyr Glu Gln Glu Trp Val Arg Leu His 
1105                1110                1115                1120
Leu Leu Asn Ile Gly Gly Ser Gln Asp Ile His Val Val His Phe His 
                1125                1130                1135    
Gly Gln Thr Leu Leu Glu Asn Gly Asn Lys Gln His Gln Leu Gly Val 
            1140                1145                1150        
Trp Pro Leu Leu Pro Gly Ser Phe Lys Thr Leu Glu Met Lys Ala Ser 
        1155                1160                1165            
Lys Pro Gly Trp Trp Leu Leu Asn Thr Glu Val Gly Glu Asn Gln Arg 
    1170                1175                1180                
Ala Gly Met Gln Thr Pro Phe Leu Ile Met Asp Arg Asp Cys Arg Met 
1185                1190                1195                1200
Pro Met Gly Leu Ser Thr Gly Ile Ile Ser Asp Ser Gln Ile Lys Ala 
                1205                1210                1215    
Ser Glu Phe Leu Gly Tyr Trp Glu Pro Arg Leu Ala Arg Leu Asn Asn 
            1220                1225                1230        
Gly Gly Ser Tyr Asn Ala Trp Ser Val Glu Lys Leu Ala Ala Glu Phe 
        1235                1240                1245            
Ala Ser Lys Pro Trp Ile Gln Val Asp Met Gln Lys Glu Val Ile Ile 
    1250                1255                1260                
Thr Gly Ile Gln Thr Gln Gly Ala Lys His Tyr Leu Lys Ser Cys Tyr 
1265                1270                1275                1280
Thr Thr Glu Phe Tyr Val Ala Tyr Ser Ser Asn Gln Ile Asn Trp Gln 
                1285                1290                1295    
Ile Phe Lys Gly Asn Ser Thr Arg Asn Val Met Tyr Phe Asn Gly Asn 
            1300                1305                1310        
Ser Asp Ala Ser Thr Ile Lys Glu Asn Gln Phe Asp Pro Pro Ile Val 
        1315                1320                1325            
Ala Arg Tyr Ile Arg Ile Ser Pro Thr Arg Ala Tyr Asn Arg Pro Thr 
    1330                1335                1340                
Leu Arg Leu Glu Leu Gln Gly Cys Glu Val Asn Gly Cys Ser Thr Pro 
1345                1350                1355                1360
Leu Gly Met Glu Asn Gly Lys Ile Glu Asn Lys Gln Ile Thr Ala Ser 
                1365                1370                1375    
Ser Phe Lys Lys Ser Trp Trp Gly Asp Tyr Trp Glu Pro Phe Arg Ala 
            1380                1385                1390        
Arg Leu Asn Ala Gln Gly Arg Val Asn Ala Trp Gln Ala Lys Ala Asn 
        1395                1400                1405            
Asn Asn Lys Gln Trp Leu Glu Ile Asp Leu Leu Lys Ile Lys Lys Ile 
    1410                1415                1420                
Thr Ala Ile Ile Thr Gln Gly Cys Lys Ser Leu Ser Ser Glu Met Tyr 
1425                1430                1435                1440
Val Lys Ser Tyr Thr Ile His Tyr Ser Glu Gln Gly Val Glu Trp Lys 
                1445                1450                1455    
Pro Tyr Arg Leu Lys Ser Ser Met Val Asp Lys Ile Phe Glu Gly Asn 
            1460                1465                1470        
Thr Asn Thr Lys Gly His Val Lys Asn Phe Phe Asn Pro Pro Ile Ile 
        1475                1480                1485            
Ser Arg Phe Ile Arg Val Ile Pro Lys Thr Trp Asn Gln Ser Ile Thr 
    1490                1495                1500                
Leu Arg Leu Glu Leu Phe Gly Cys Asp Ile Tyr 
1505                1510                1515

<210> 4
<211> 1428
<212> PRT
<213> Homo sapiens


<400> 4
Ala Gln Leu Arg Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser 
1               5                   10                  15      
Tyr Arg Pro Glu Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser 
            20                  25                  30          
Phe Lys Lys Ile Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu 
        35                  40                  45              
Lys Pro Gln Ser Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala 
    50                  55                  60                  
Glu Val Gly Asp Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys 
65                  70                  75                  80  
Pro Leu Ser Ile His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu 
                85                  90                  95      
Gly Ala Ser Tyr Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp 
            100                 105                 110         
Ala Val Ala Pro Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu 
        115                 120                 125             
Asp Ser Gly Pro Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr 
    130                 135                 140                 
Tyr Ser His Glu Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly 
145                 150                 155                 160 
Pro Leu Leu Ile Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln 
                165                 170                 175     
Lys Thr Phe Asp Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu 
            180                 185                 190         
Ser Lys Ser Trp Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly 
        195                 200                 205             
Tyr Val Asn Gly Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His 
    210                 215                 220                 
Ile Ser Trp His Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser 
225                 230                 235                 240 
Ile His Phe Asn Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser 
                245                 250                 255     
Ala Ile Thr Leu Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val 
            260                 265                 270         
Gly Pro Glu Gly Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu 
        275                 280                 285             
Gln Ala Gly Met Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys 
    290                 295                 300                 
Thr Arg Asn Leu Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys 
305                 310                 315                 320 
Arg Trp Glu Tyr Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala 
                325                 330                 335     
Pro Val Ile Pro Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu 
            340                 345                 350         
Asp Asn Phe Ser Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr 
        355                 360                 365             
Thr Gln Tyr Glu Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn 
    370                 375                 380                 
Met Lys Glu Asp Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg 
385                 390                 395                 400 
Asp Thr Leu Lys Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser 
                405                 410                 415     
Ile Tyr Pro His Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn 
            420                 425                 430         
Ser Ser Phe Thr Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln 
        435                 440                 445             
Pro Gly Glu Thr Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu 
    450                 455                 460                 
Pro Thr Glu Asn Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp 
465                 470                 475                 480 
Val Asp Ile Met Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu 
                485                 490                 495     
Ile Cys Lys Ser Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala 
            500                 505                 510         
Asp Ile Glu Gln Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser 
        515                 520                 525             
Trp Tyr Leu Glu Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu 
    530                 535                 540                 
Val Lys Arg Asp Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr 
545                 550                 555                 560 
Ile Asn Gly Tyr Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe 
                565                 570                 575     
Asp Asp Thr Val Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu 
            580                 585                 590         
Ile Leu Thr Ile His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg 
        595                 600                 605             
His Glu Asp Thr Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr 
    610                 615                 620                 
Val Thr Met Asp Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser 
625                 630                 635                 640 
Ser Pro Arg Ser Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys 
                645                 650                 655     
Ile Pro Asp Asp Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu 
            660                 665                 670         
Ser Thr Val Met Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu 
        675                 680                 685             
Asp Glu Glu Ser Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala 
    690                 695                 700                 
Ala Leu Gly Thr Arg Glu Phe Asn Pro Leu Val Ile Val Gly Leu Ser 
705                 710                 715                 720 
Lys Asp Gly Thr Asp Tyr Ile Glu Ile Ile Pro Lys Glu Glu Val Gln 
                725                 730                 735     
Ser Ser Glu Asp Asp Tyr Ala Glu Ile Asp Tyr Val Pro Tyr Asp Asp 
            740                 745                 750         
Pro Tyr Lys Thr Asp Val Arg Thr Asn Ile Asn Ser Ser Arg Asp Pro 
        755                 760                 765             
Asp Asn Ile Ala Ala Trp Tyr Thr Arg Ser Asn Asn Gly Asn Arg Arg 
    770                 775                 780                 
Asn Tyr Tyr Ile Ala Ala Glu Glu Ile Ser Trp Asp Tyr Ser Glu Phe 
785                 790                 795                 800 
Val Gln Arg Glu Thr Asp Ile Glu Asp Ser Asp Asp Ile Pro Glu Asp 
                805                 810                 815     
Thr Thr Tyr Lys Lys Val Val Phe Arg Lys Tyr Leu Asp Ser Thr Phe 
            820                 825                 830         
Thr Lys Arg Asp Pro Arg Gly Glu Tyr Glu Glu His Leu Gly Ile Leu 
        835                 840                 845             
Gly Pro Ile Ile Arg Ala Glu Val Asp Asp Val Ile Gln Val Arg Phe 
    850                 855                 860                 
Lys Asn Leu Ala Ser Arg Pro Tyr Ser Leu His Ala His Gly Leu Ser 
865                 870                 875                 880 
Tyr Glu Lys Ser Ser Glu Gly Lys Thr Tyr Glu Asp Asp Ser Pro Glu 
                885                 890                 895     
Trp Phe Lys Glu Asp Asn Ala Val Gln Pro Asn Ser Ser Tyr Thr Tyr 
            900                 905                 910         
Val Trp His Ala Thr Glu Arg Ser Gly Pro Glu Ser Pro Gly Ser Ala 
        915                 920                 925             
Cys Arg Ala Trp Ala Tyr Tyr Ser Ala Val Asn Pro Glu Lys Asp Ile 
    930                 935                 940                 
His Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Gln Lys Gly Ile Leu 
945                 950                 955                 960 
His Lys Asp Ser Asn Met Pro Met Asp Met Arg Glu Phe Val Leu Leu 
                965                 970                 975     
Phe Met Thr Phe Asp Glu Lys Lys Ser Trp Tyr Tyr Glu Lys Lys Ser 
            980                 985                 990         
Arg Ser Ser Trp Arg Leu Thr Ser Ser Glu Met Lys Lys Ser His Glu 
        995                 1000                1005            
Phe His Ala Ile Asn Gly Met Ile Tyr Ser Leu Pro Gly Leu Lys Met 
    1010                1015                1020                
Tyr Glu Gln Glu Trp Val Arg Leu His Leu Leu Asn Ile Gly Gly Ser 
1025                1030                1035                1040
Gln Asp Ile His Val Val His Phe His Gly Gln Thr Leu Leu Glu Asn 
                1045                1050                1055    
Gly Asn Lys Gln His Gln Leu Gly Val Trp Pro Leu Leu Pro Gly Ser 
            1060                1065                1070        
Phe Lys Thr Leu Glu Met Lys Ala Ser Lys Pro Gly Trp Trp Leu Leu 
        1075                1080                1085            
Asn Thr Glu Val Gly Glu Asn Gln Arg Ala Gly Met Gln Thr Pro Phe 
    1090                1095                1100                
Leu Ile Met Asp Arg Asp Cys Arg Met Pro Met Gly Leu Ser Thr Gly 
1105                1110                1115                1120
Ile Ile Ser Asp Ser Gln Ile Lys Ala Ser Glu Phe Leu Gly Tyr Trp 
                1125                1130                1135    
Glu Pro Arg Leu Ala Arg Leu Asn Asn Gly Gly Ser Tyr Asn Ala Trp 
            1140                1145                1150        
Ser Val Glu Lys Leu Ala Ala Glu Phe Ala Ser Lys Pro Trp Ile Gln 
        1155                1160                1165            
Val Asp Met Gln Lys Glu Val Ile Ile Thr Gly Ile Gln Thr Gln Gly 
    1170                1175                1180                
Ala Lys His Tyr Leu Lys Ser Cys Tyr Thr Thr Glu Phe Tyr Val Ala 
1185                1190                1195                1200
Tyr Ser Ser Asn Gln Ile Asn Trp Gln Ile Phe Lys Gly Asn Ser Thr 
                1205                1210                1215    
Arg Asn Val Met Tyr Phe Asn Gly Asn Ser Asp Ala Ser Thr Ile Lys 
            1220                1225                1230        
Glu Asn Gln Phe Asp Pro Pro Ile Val Ala Arg Tyr Ile Arg Ile Ser 
        1235                1240                1245            
Pro Thr Arg Ala Tyr Asn Arg Pro Thr Leu Arg Leu Glu Leu Gln Gly 
    1250                1255                1260                
Cys Glu Val Asn Gly Cys Ser Thr Pro Leu Gly Met Glu Asn Gly Lys 
1265                1270                1275                1280
Ile Glu Asn Lys Gln Ile Thr Ala Ser Ser Phe Lys Lys Ser Trp Trp 
                1285                1290                1295    
Gly Asp Tyr Trp Glu Pro Phe Arg Ala Arg Leu Asn Ala Gln Gly Arg 
            1300                1305                1310        
Val Asn Ala Trp Gln Ala Lys Ala Asn Asn Asn Lys Gln Trp Leu Glu 
        1315                1320                1325            
Ile Asp Leu Leu Lys Ile Lys Lys Ile Thr Ala Ile Ile Thr Gln Gly 
    1330                1335                1340                
Cys Lys Ser Leu Ser Ser Glu Met Tyr Val Lys Ser Tyr Thr Ile His 
1345                1350                1355                1360
Tyr Ser Glu Gln Gly Val Glu Trp Lys Pro Tyr Arg Leu Lys Ser Ser 
                1365                1370                1375    
Met Val Asp Lys Ile Phe Glu Gly Asn Thr Asn Thr Lys Gly His Val 
            1380                1385                1390        
Lys Asn Phe Phe Asn Pro Pro Ile Ile Ser Arg Phe Ile Arg Val Ile 
        1395                1400                1405            
Pro Lys Thr Trp Asn Gln Ser Ile Ala Leu Arg Leu Glu Leu Phe Gly 
    1410                1415                1420                
Cys Asp Ile Tyr 
1425            

<210> 5
<211> 251
<212> PRT
<213> Homo sapiens


<400> 5
Met Ile Tyr Thr Met Lys Lys Val His Ala Leu Trp Ala Ser Val Cys 
1               5                   10                  15      
Leu Leu Leu Asn Leu Ala Pro Ala Pro Leu Asn Ala Asp Ser Glu Glu 
            20                  25                  30          
Asp Glu Glu His Thr Ile Ile Thr Asp Thr Glu Leu Pro Pro Leu Lys 
        35                  40                  45              
Leu Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Lys 
    50                  55                  60                  
Ala Ile Met Lys Arg Phe Phe Phe Asn Ile Phe Thr Arg Gln Cys Glu 
65                  70                  75                  80  
Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln Asn Arg Phe Glu Ser 
                85                  90                  95      
Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp Asn Ala Asn Arg Ile 
            100                 105                 110         
Ile Lys Thr Thr Leu Gln Gln Glu Lys Pro Asp Phe Cys Phe Leu Glu 
        115                 120                 125             
Glu Asp Pro Gly Ile Cys Arg Gly Tyr Ile Thr Arg Tyr Phe Tyr Asn 
    130                 135                 140                 
Asn Gln Thr Lys Gln Cys Glu Arg Phe Lys Tyr Gly Gly Cys Leu Gly 
145                 150                 155                 160 
Asn Met Asn Asn Phe Glu Thr Leu Glu Glu Cys Lys Asn Ile Cys Glu 
                165                 170                 175     
Asp Gly Pro Asn Gly Phe Gln Val Asp Asn Tyr Gly Thr Gln Leu Asn 
            180                 185                 190         
Ala Val Asn Asn Ser Leu Thr Pro Gln Ser Thr Lys Val Pro Ser Leu 
        195                 200                 205             
Phe Val Thr Lys Glu Gly Thr Asn Asp Gly Trp Lys Asn Ala Ala His 
    210                 215                 220                 
Ile Tyr Gln Val Phe Leu Asn Ala Phe Cys Ile His Ala Ser Met Phe 
225                 230                 235                 240 
Phe Leu Gly Leu Asp Ser Ile Ser Cys Leu Cys 
                245                 250     

