                         SEQUENCE LISTING

<110>  Universitt fr Bodenkultur
 
<120>  PLANT SERINE PROTEASES

<130>  25466-WO

<150>  EP 18198240.6
<151>  2018-10-02

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Serine protease motif


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a peptide consisting of 7 amino acid residues

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is I or L

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is T or M

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is a peptide consisting of 27 or 28 amino acid residues

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is a peptide consisting of 12 amino acid residues

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X is T or E

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is S or A

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X is I or M

<400>  1

Ser Ser Arg Gly Pro Xaa Leu Lys Pro Asp Xaa Xaa Ala Pro Gly Xaa 
1               5                   10                  15      


Ser Gly Thr Ser Met Ser Cys Pro His Xaa Pro Xaa Trp Ser Pro Xaa 
            20                  25                  30          


Ala Xaa Xaa Ser Ala Xaa Met Thr Thr 
        35                  40      


<210>  2
<211>  770
<212>  PRT
<213>  Nicotiana benthamiana

<400>  2

Met Lys Gly Ile Ile Ser Leu Phe Phe Cys Phe Ser Leu Phe Ile Val 
1               5                   10                  15      


Ser Phe Ile Leu Arg Glu Ala Asp Ser Ala Ser Gln Ala Gln Asn Asn 
            20                  25                  30          


Gly Ile Tyr Ile Val Tyr Met Gly Ala Ala Ala Ser Ser Asn Gly Gly 
        35                  40                  45              


Thr Arg His Asp Gln Ala Arg Leu Ile Ser Ser Leu Ile Arg Arg Asn 
    50                  55                  60                  


Lys His Ala Val Val His Ser Tyr Asn Asn Gly Phe Ser Gly Phe Ala 
65                  70                  75                  80  


Ala Arg Leu Ser Glu Ser Glu Ala Lys Ser Met Ala Gln Arg Pro Gly 
                85                  90                  95      


Val Ile Ser Val Phe Pro Asp Pro Val Leu Gln Leu His Thr Thr His 
            100                 105                 110         


Ser Trp Asp Phe Leu Lys Tyr Gln Thr Asp Glu Lys Ile Asn Ser Ser 
        115                 120                 125             


Pro Ser Ser Gly Ser Asp Ser Ser Leu Ile Gly Ala Asp Thr Ile Ile 
    130                 135                 140                 


Gly Ile Leu Asp Thr Gly Ile Trp Pro Glu Ser Glu Ser Phe Asn Asp 
145                 150                 155                 160 


Lys Asp Met Gly Pro Ile Pro Ser Arg Trp Asn Gly Thr Cys Met Asp 
                165                 170                 175     


Gly Gln Asp Phe Gly Ser Ser Lys Cys Asn Lys Lys Ile Val Gly Ala 
            180                 185                 190         


Arg Phe Tyr Glu Glu Ser Asp Asp Ser Gly Thr Lys Ile Ala Gly Ser 
        195                 200                 205             


Ala Arg Asp Glu Asn Gly His Gly Thr His Val Ala Ser Thr Ala Ala 
    210                 215                 220                 


Gly Ser Pro Val Ala Gly Ala Ser Tyr Tyr Gly Leu Ala Ala Gly Thr 
225                 230                 235                 240 


Ala Thr Gly Gly Ser Pro Gly Ser Arg Ile Ser Met Tyr Arg Val Cys 
                245                 250                 255     


Thr Thr Phe Gly Cys Arg Gly Ser Ala Ile Met Lys Ala Phe Asp Asp 
            260                 265                 270         


Ala Ile Ala Asp Gly Val Asp Val Leu Ser Leu Ser Leu Gly Ser Ser 
        275                 280                 285             


Pro Gly Leu Glu Pro Asp Phe Pro Ser Asn Pro Ile Ala Ile Gly Ala 
    290                 295                 300                 


Phe His Ala Val Glu Lys Gly Ile Thr Val Val Cys Ser Ala Gly Asn 
305                 310                 315                 320 


Ser Gly Pro Gly Pro Lys Thr Val Val Asn Thr Ala Pro Trp Ile Leu 
                325                 330                 335     


Thr Val Ala Ala Thr Thr Ile Asp Arg Asp Phe Glu Thr Asp Ile Val 
            340                 345                 350         


Leu Gly Gly Asn Lys Leu Ile Lys Gly Gly Gly Ile Asn Phe Gly Asn 
        355                 360                 365             


Met Thr Lys Ser Ser Val Tyr Pro Leu Ile His Gly Asn Ser Thr Lys 
    370                 375                 380                 


Ser Asn Asp Asn Val Ser Glu Ala Asp Ala Arg Ser Cys Val Pro Gly 
385                 390                 395                 400 


Ser Leu Asp Glu Asn Lys Val Lys Gly Lys Ile Val Leu Cys Glu Asn 
                405                 410                 415     


Leu Asp Asp Gly Glu Tyr Phe Pro Ser Asp Lys Leu Asp Glu Val Lys 
            420                 425                 430         


Ser Arg Gly Gly Val Gly Phe Ile Leu Ile Asp Asp Asp Glu Arg Thr 
        435                 440                 445             


Val Ala Pro Lys Phe Asn Ser Phe Ser Ala Gly Val Val Ser Lys Lys 
    450                 455                 460                 


Asp Gly Asn Glu Ile Leu Ala Tyr Ile Asn Ser Thr Arg Asn Pro Val 
465                 470                 475                 480 


Ala Ser Ile Leu Pro Thr Val Ser Ile Thr Lys Tyr Lys Pro Ala Pro 
                485                 490                 495     


Val Val Ala Tyr Phe Ser Ser Arg Gly Pro Ala Tyr Asn Thr Pro Asn 
            500                 505                 510         


Leu Leu Lys Pro Asp Ile Thr Ala Pro Gly Val Ala Ile Leu Ala Ala 
        515                 520                 525             


Trp Pro Gly Asn Asp Thr Ser Glu Ala Leu Pro Gly Gln Lys Pro Pro 
    530                 535                 540                 


Ile Phe Asn Leu Leu Ser Gly Thr Ser Met Ser Cys Pro His Val Ser 
545                 550                 555                 560 


Gly Ile Ala Ala Thr Val Lys Ala Val Asn Pro Thr Trp Ser Pro Ser 
                565                 570                 575     


Ala Val Lys Ser Ala Ile Met Thr Thr Ala Ile Gln Thr Asn Asn Leu 
            580                 585                 590         


Lys Ala Pro Ile Thr Thr Val Ser Gly Ser Lys Ala Thr Pro Tyr Asp 
        595                 600                 605             


Ile Gly Ala Gly Glu Ala Ser Thr Ser Gly Pro Leu Lys Pro Gly Leu 
    610                 615                 620                 


Val Tyr Glu Thr Asp Val Ala Asp Tyr Leu Gln Phe Leu Cys Ser Val 
625                 630                 635                 640 


Gly Phe Asn Ile Ser Gln Ile Lys Leu Ile Ser Ile Thr Val Pro Glu 
                645                 650                 655     


Asp Phe Ser Cys Pro Lys Asn Ser Thr Ser Glu Leu Val Ser Asn Met 
            660                 665                 670         


Asn Tyr Pro Ser Ile Ala Ile Ser Ser Leu Lys Glu Asn Glu Pro Lys 
        675                 680                 685             


Lys Val Thr Arg Thr Val Thr Asn Thr Gly Glu Glu Ala Ser Val Tyr 
    690                 695                 700                 


Thr Thr Val Ile Glu Ala Pro Lys Gly Leu Glu Val Gln Val Ile Pro 
705                 710                 715                 720 


Thr Lys Leu Glu Phe Thr Asn Lys Ser Lys Lys Leu Ser Tyr Asp Val 
                725                 730                 735     


Ser Phe Lys Ala Ser Ser Thr Ser Lys Glu Asp Leu Phe Gly Ser Ile 
            740                 745                 750         


Thr Trp Thr Asn Gly Lys Tyr Lys Val Arg Ser Pro Phe Val Val Ser 
        755                 760                 765             


Ser Asn 
    770 


<210>  3
<211>  2313
<212>  DNA
<213>  Nicotiana benthamiana

<400>  3
atgaaaggaa ttatatcttt gtttttctgc ttttctcttt tcattgtctc tttcatatta       60

agagaagccg actcagcttc tcaagcacaa aacaatggaa tttatattgt ttatatgggt      120

gctgcagctt catctaatgg tggtaccaga catgatcaag cgcggcttat cagctccttg      180

atcagaagga acaagcatgc agtggtacac agctacaaca atggtttctc aggattcgcg      240

gcacgtttat cagaatctga agctaaatcc atggctcaaa gacctggagt tatctccgta      300

tttcctgatc cagtactgca actccacact acacattcat gggatttctt gaagtatcaa      360

actgatgaaa aaatcaattc aagtccaagc tctggttctg attcatcatt aattggagct      420

gataccataa ttggcatatt ggatacgggt atatggccag aatctgagag tttcaatgac      480

aaggatatgg gtccaattcc atcccggtgg aatggaactt gcatggatgg tcaagatttt      540

ggctcttcaa aatgcaacaa gaagatagtt ggtgcaagat tttatgagga gtctgatgac      600

agtggaacaa aaatcgctgg atcagccagg gacgagaacg gacatggtac tcatgttgcg      660

tctactgcag ctgggagtcc tgttgcaggt gcatcctact atggcctagc tgcaggaact      720

gccacgggtg gatctcctgg ttcgaggatt tccatgtatc gtgtctgtac tacttttgga      780

tgccgcggat cagctatcat gaaagcattc gatgatgcaa ttgcagatgg ggttgatgtt      840

ttatcactat cacttggttc atcacctgga cttgaacctg attttccaag caatcctatt      900

gccataggag catttcatgc tgtagaaaag ggcattactg ttgtttgctc tgctggaaat      960

agtggccctg gaccaaaaac tgttgtcaat acagctcctt ggattcttac tgttgcagcc     1020

accaccattg atcgtgactt cgagacagat attgtcttgg gtggaaacaa gcttattaag     1080

ggtggaggta taaactttgg taacatgaca aaatcgtcag tctacccttt gattcatggc     1140

aattcaacca aatcaaacga taatgtttct gaggcggatg caaggagttg tgttcctggt     1200

tcattagatg aaaacaaagt caaggggaag attgtccttt gtgaaaatct tgatgatggt     1260

gaatattttc ccagtgacaa gctagatgaa gtgaaaagcc gaggtggagt tggatttata     1320

cttatagatg atgatgaaag aactgtggca cccaaattca attccttctc agctggtgta     1380

gtctctaaaa aggatggaaa tgagatcctc gcctacatta actcgacgag gaatccagtt     1440

gcatcaattt taccaactgt atccataaca aagtacaaac cagctccagt tgtggcttac     1500

ttctcatcaa gaggccctgc gtacaacacc cctaacctcc tcaaaccgga tattacagca     1560

ccaggggttg ccattcttgc tgcttggcct ggaaatgaca cgagtgaggc tctccccggc     1620

caaaaaccac caattttcaa cctactctca ggcacttcca tgtcctgccc tcatgtatcc     1680

ggtattgctg ctactgtcaa agcagtaaac cctacctgga gtccttcagc tgtcaaatca     1740

gctattatga ccacagctat tcagacaaac aatttgaagg ctccaatcac tacagtctca     1800

ggatccaaag caacaccata tgacataggt gcaggagaag caagcacttc aggtccatta     1860

aaaccaggtc tagtctacga gacagatgtc gccgactact tgcagttcct atgttctgtt     1920

ggttttaaca tatcacagat aaagctgatc tcaattacag ttcctgaaga cttttcatgc     1980

ccaaaaaact caacctctga attggtttct aatatgaatt atccatcaat agctatttct     2040

agtctcaaag aaaacgagcc gaagaaagtt actagaactg taacaaatac tggtgaagaa     2100

gcatcagtat atactacagt tattgaggca ccaaaaggat tggaagtcca agtgatccca     2160

actaaattgg aatttacaaa taaaagcaag aaattaagct atgatgtgtc tttcaaagct     2220

tcatctacct caaaggaaga tctgtttgga tcaattactt ggactaatgg taagtacaaa     2280

gtccggagtc cattcgtcgt aagtagcaac taa                                  2313


<210>  4
<211>  768
<212>  PRT
<213>  Nicotiana tabacum

<400>  4

Met Lys Gly Leu Ser Leu Phe Phe Cys Phe Ser Leu Phe Ile Val Ala 
1               5                   10                  15      


Phe Ile Arg Glu Ala Asp Ser Ala Ser Gln Ala Gln Asn Asn Gly Ile 
            20                  25                  30          


Tyr Ile Val Tyr Met Gly Ala Ala Ala Ser Ser Asn Gly Gly Thr Arg 
        35                  40                  45              


His Asp Gln Ala Gln Leu Ile Ser Ser Leu Ile Arg Arg Asn Lys Asn 
    50                  55                  60                  


Ala Val Val His Ser Tyr Asn Asn Gly Phe Ser Gly Phe Ala Ala Arg 
65                  70                  75                  80  


Leu Ser Glu Ala Glu Ala Lys Ser Met Ala Gln Arg Pro Gly Val Ile 
                85                  90                  95      


Ser Val Phe Pro Asp Pro Val Leu Gln Leu His Thr Thr His Ser Trp 
            100                 105                 110         


Asp Phe Leu Lys Tyr Gln Thr Asp Glu Lys Ile Asn Ser Ser Pro Ser 
        115                 120                 125             


Ser Gly Ser Asp Ser Ser Leu Ile Gly Ala Asp Thr Ile Ile Gly Ile 
    130                 135                 140                 


Leu Asp Thr Gly Ile Trp Pro Glu Ser Glu Ser Phe Asn Asp Lys Asp 
145                 150                 155                 160 


Met Gly Pro Ile Pro Ala Arg Trp Asn Gly Thr Cys Met Asp Gly Gln 
                165                 170                 175     


Asp Phe Gly Ser Ser Lys Cys Asn Lys Lys Ile Val Gly Ala Arg Phe 
            180                 185                 190         


Tyr Glu Glu Ser Asp Asp Ser Gly Ile Lys Ile Ala Gly Ser Ala Arg 
        195                 200                 205             


Asp Glu Asn Gly His Gly Thr His Val Ala Ser Thr Ala Ala Gly Ser 
    210                 215                 220                 


Pro Val Ala Gly Ala Ser Tyr Tyr Gly Leu Ala Ala Gly Thr Ala Thr 
225                 230                 235                 240 


Gly Gly Ser Pro Gly Ser Arg Ile Ala Met Tyr Arg Val Cys Thr Thr 
                245                 250                 255     


Phe Gly Cys Arg Gly Ser Ala Ile Met Lys Ala Phe Asp Asp Ala Ile 
            260                 265                 270         


Ala Asp Gly Val Asp Val Leu Ser Leu Ser Leu Gly Ser Ser Pro Gly 
        275                 280                 285             


Leu Glu Pro Asp Phe Pro Ser Asn Pro Ile Ala Ile Gly Ala Phe His 
    290                 295                 300                 


Ala Val Glu Lys Gly Ile Val Val Val Cys Ser Ala Gly Asn Ser Gly 
305                 310                 315                 320 


Pro Gly Pro Lys Thr Val Val Asn Thr Ala Pro Trp Ile Leu Thr Val 
                325                 330                 335     


Ala Ala Thr Thr Ile Asp Arg Asp Phe Glu Thr Asp Ile Val Leu Gly 
            340                 345                 350         


Gly Asn Lys Leu Ile Lys Gly Gly Gly Ile Asn Phe Gly Asn Met Thr 
        355                 360                 365             


Lys Ser Ser Val Tyr Pro Leu Ile His Gly Asn Ser Thr Lys Ser Asn 
    370                 375                 380                 


Asn Asn Val Ser Glu Ala Asp Ala Arg Ser Cys Val Pro Gly Ser Leu 
385                 390                 395                 400 


Asp Glu Asn Lys Val Lys Gly Lys Ile Val Leu Cys Glu Asn Leu Asp 
                405                 410                 415     


Asp Gly Glu Tyr Phe Pro Ser Asp Lys Leu Asp Glu Val Lys Ser Arg 
            420                 425                 430         


Gly Gly Val Gly Phe Ile Leu Ile Asp Asp Asp Glu Arg Thr Val Ala 
        435                 440                 445             


Pro Lys Phe Asn Ser Phe Pro Ala Gly Val Val Ser Lys Lys Asp Gly 
    450                 455                 460                 


Thr Glu Ile Leu Ala Tyr Ile Asn Ser Thr Arg Asn Pro Ile Ala Ser 
465                 470                 475                 480 


Ile Leu Pro Thr Val Ser Ile Thr Lys Tyr Lys Pro Ala Pro Val Val 
                485                 490                 495     


Ala Tyr Phe Ser Ser Arg Gly Pro Ala Tyr Asn Thr Pro Asn Leu Leu 
            500                 505                 510         


Lys Pro Asp Ile Thr Ala Pro Gly Val Ala Ile Leu Ala Ala Trp Pro 
        515                 520                 525             


Gly Asn Asp Thr Ser Glu Ala Leu Pro Gly Gln Lys Pro Pro Ile Phe 
    530                 535                 540                 


Asn Leu Leu Ser Gly Thr Ser Met Ser Cys Pro His Val Ser Gly Ile 
545                 550                 555                 560 


Ala Ala Thr Val Lys Ala Val Asn Pro Ala Trp Ser Pro Ser Ala Val 
                565                 570                 575     


Lys Ser Ala Ile Met Thr Thr Ala Ile Gln Ile Asn Asn Leu Lys Ala 
            580                 585                 590         


Pro Ile Thr Thr Val Ser Gly Ser Lys Ala Thr Pro Tyr Asp Ile Gly 
        595                 600                 605             


Ala Gly Glu Ala Ser Thr Ser Gly Pro Leu Lys Pro Gly Leu Val Tyr 
    610                 615                 620                 


Glu Thr Asp Val Ala Asp Tyr Leu Gln Phe Leu Cys Ser Ala Gly Phe 
625                 630                 635                 640 


Asn Ile Ser Gln Ile Lys Leu Ile Ser Ser Thr Val Pro Lys Asp Phe 
                645                 650                 655     


Ser Cys Pro Lys Asn Pro Thr Ser Glu Leu Val Ser Asn Met Asn Tyr 
            660                 665                 670         


Pro Ser Ile Ala Ile Ser Ser Leu Lys Glu Asn Glu Pro Lys Lys Val 
        675                 680                 685             


Thr Arg Thr Val Thr Asn Thr Gly Glu Glu Ala Ser Val Tyr Thr Ala 
    690                 695                 700                 


Ile Ile Glu Ala Pro Lys Gly Leu Glu Val Gln Val Ile Pro Ser Lys 
705                 710                 715                 720 


Leu Glu Phe Asn Tyr Lys Ser Lys Lys Leu Ser Tyr Glu Val Ser Phe 
                725                 730                 735     


Lys Ala Ser Ser Pro Ser Lys Glu Asp Leu Phe Gly Ser Ile Thr Trp 
            740                 745                 750         


Thr Asn Gly Lys Tyr Lys Val Arg Ser Pro Phe Val Val Ser Ser Asn 
        755                 760                 765             


<210>  5
<211>  2307
<212>  DNA
<213>  Nicotiana tabacum

<400>  5
atgaaaggcc tttctttgtt cttctgcttt tctcttttca ttgtcgcttt cataagagaa       60

gccgactcag cttctcaagc acaaaacaat ggcatttata ttgtttatat gggtgctgcg      120

gcttcttcta acggtggtac cagacatgat caagcgcagc ttatcagctc cttgatcaga      180

aggaacaaga atgcagtggt acacagctac aacaatggtt tctcaggatt cgcggcacgt      240

ttatcagaag ctgaagctaa atccatggct caaagacctg gagttatctc tgtatttcct      300

gatccagtac tgcaactcca cactacacat tcatgggatt tcttgaagta tcaaactgat      360

gaaaaaatca attcaagtcc aagctctggt tctgattcat cattaattgg agctgatacc      420

ataattggca tattggatac gggtatatgg ccagaatctg agagtttcaa tgacaaggat      480

atgggtccaa ttccagcccg gtggaatgga acttgcatgg atggtcaaga ttttggctct      540

tcaaaatgca acaagaagat agttggtgca agattttatg aggagtctga tgacagtgga      600

ataaaaatcg ctggatcagc cagggacgag aacggacatg gtactcatgt tgcgtctact      660

gcagctggga gtcctgttgc aggtgcatcc tactatggcc tagctgcagg aactgccacg      720

ggtggatctc ctggttcaag gattgccatg tatcgtgtct gtactacttt tggatgccgt      780

ggatcagcta tcatgaaagc attcgatgac gcaattgcag atggggttga tgttttatca      840

ctatcacttg gttcatcacc cggacttgaa cctgattttc cgagcaatcc tattgccata      900

ggagcatttc atgccgtaga aaagggcatt gttgttgttt gctctgctgg aaatagtggc      960

cctggcccaa aaactgttgt caatacagct ccttggattc taacggttgc agccaccacc     1020

attgatcgtg acttcgagac agatattgtc ttgggtggaa acaagcttat taagggtgga     1080

ggtataaact ttggtaacat gacaaaatcg tcagtctacc ctttgattca tggcaattca     1140

accaaatcaa acaataatgt ttctgaggcg gatgcaagga gttgtgttcc tggttcatta     1200

gatgaaaaca aagtcaaggg gaagattgtt ctttgtgaaa atcttgatga tggcgaatat     1260

tttcccagtg acaagctaga cgaagtgaag agtcgaggtg gagttggatt tatactaata     1320

gatgatgatg aaagaactgt ggcacccaaa ttcaattcct tcccagcagg tgtagtctct     1380

aaaaaggatg gtactgagat ccttgcctac attaactcga ctaggaatcc cattgcatca     1440

attttaccaa ctgtttccat aacaaagtac aaaccagctc cagttgtcgc ttacttctca     1500

tcaagaggcc ctgcgtacaa cacccctaac ctcctcaaac cggatattac agcaccaggg     1560

gttgccattc ttgctgcttg gcctggaaat gacacgagtg aggctctccc cggccaaaaa     1620

ccaccaattt tcaacctact ctcaggcact tccatgtcct gccctcacgt atccggtatt     1680

gctgcaactg tcaaagcagt taaccctgcc tggagtcctt cagctgtcaa atcagctatt     1740

atgaccacag ctattcagat aaacaatttg aaggctccaa tcactacagt ctcaggatcc     1800

aaagcaacac catatgacat aggtgcagga gaagcaagca cttcaggtcc attaaaacca     1860

ggtctagtct acgagacaga tgtcgccgac tacttgcagt tcctatgttc tgctggcttt     1920

aacatatcac agataaagct gatctcaagt acagttccta aggacttttc atgcccaaaa     1980

aacccaacct ctgaattggt ttctaatatg aattatccat caatagctat ttctagtctc     2040

aaagaaaacg agccgaagaa agttactaga acagttacaa atactggtga agaagcatca     2100

gtatatactg caatcattga ggcaccaaaa ggattggaag tccaagtgat tccaagtaaa     2160

ttggaattta attataaaag caagaaatta agctatgaag tgtctttcaa agcttcatct     2220

ccctcaaagg aggatctgtt tggctcaatt acttggacaa atggtaagta caaagtccgg     2280

agtccatttg ttgtaagtag caactaa                                         2307


<210>  6
<211>  768
<212>  PRT
<213>  Nicotiana tabacum

<400>  6

Met Lys Gly Leu Phe Leu Phe Ile Cys Phe Ser Leu Phe Ile Val Ser 
1               5                   10                  15      


Phe Ile Ile Glu Ala Asp Ser Ala Ser Gln Ser Gln Asn Asn Gly Ile 
            20                  25                  30          


Tyr Ile Val Tyr Met Gly Ala Ala Ala Ser Ser Asn Gly Gly Thr Arg 
        35                  40                  45              


His Asp Gln Ala Gln Leu Ile Ser Ser Leu Ile Arg Arg Asn Lys Asn 
    50                  55                  60                  


Ala Val Val His Ser Tyr Lys Asn Gly Phe Ser Gly Phe Ala Ala Arg 
65                  70                  75                  80  


Leu Ser Glu Ala Glu Ala Lys Ser Met Ala Gln Arg Pro Gly Val Val 
                85                  90                  95      


Ser Val Phe Pro Asp Pro Val Leu Gln Leu His Thr Thr His Ser Trp 
            100                 105                 110         


Asp Phe Leu Lys Tyr Gln Thr Asp Glu Lys Ile Asn Ser Ser Pro Ser 
        115                 120                 125             


Ser Gly Ser Asp Ser Ser Leu Ile Gly Ala Asp Thr Ile Ile Gly Ile 
    130                 135                 140                 


Leu Asp Thr Gly Ile Trp Pro Glu Ser Glu Ser Phe Asn Asp Lys Asp 
145                 150                 155                 160 


Met Gly Pro Ile Pro Ala Arg Trp Asn Gly Thr Cys Met Asp Gly Gln 
                165                 170                 175     


Asp Phe Gly Ser Ser Asn Cys Asn Lys Lys Ile Val Gly Ala Arg Phe 
            180                 185                 190         


Tyr Glu Glu Ser Asp Asp Ser Gly Ile Lys Ile Thr Gly Ser Ala Arg 
        195                 200                 205             


Asp Glu Asn Gly His Gly Thr His Val Ala Ser Thr Ala Ala Gly Ser 
    210                 215                 220                 


Pro Val Ala Gly Ala Ser Tyr Tyr Gly Leu Ala Ala Gly Thr Ala Thr 
225                 230                 235                 240 


Gly Gly Ser Pro Gly Ser Arg Ile Ala Met Tyr Arg Val Cys Thr Thr 
                245                 250                 255     


Phe Gly Cys Arg Gly Ser Ala Ile Met Lys Ala Phe Asp Asp Ala Ile 
            260                 265                 270         


Ala Asp Gly Val Asp Val Leu Ser Leu Ser Leu Gly Ser Ser Pro Gly 
        275                 280                 285             


Leu Glu Pro Asp Phe Pro Thr Asn Pro Ile Ala Ile Gly Ala Phe His 
    290                 295                 300                 


Ala Val Glu Lys Gly Ile Val Val Val Cys Ser Ala Gly Asn Ser Gly 
305                 310                 315                 320 


Pro Gly Pro Lys Thr Val Val Asn Thr Ala Pro Trp Ile Leu Thr Val 
                325                 330                 335     


Ala Ala Thr Thr Ile Asp Arg Asp Phe Glu Thr Asp Val Leu Leu Gly 
            340                 345                 350         


Gly Asn Lys Leu Ile Lys Gly Gly Gly Ile Asn Phe Gly Asn Met Thr 
        355                 360                 365             


Lys Ser Thr Val Tyr Pro Leu Ile His Gly Asn Ser Thr Lys Ser Asn 
    370                 375                 380                 


Asp Asn Val Ser Glu Ala Asp Ala Arg Ser Cys Val Pro Gly Ser Leu 
385                 390                 395                 400 


Asp Glu Asn Lys Val Lys Gly Lys Ile Val Leu Cys Glu Asn Leu Asp 
                405                 410                 415     


Asp Gly Glu Tyr Phe Pro Ser Asp Lys Leu Asp Glu Val Lys Ser Arg 
            420                 425                 430         


Gly Gly Val Gly Phe Ile Leu Ile Asp Asp Asp Glu Arg Thr Val Ala 
        435                 440                 445             


Pro Lys Phe Lys Ala Phe Pro Ala Gly Val Val Ser Lys Lys Asp Gly 
    450                 455                 460                 


Thr Glu Ile Leu Ala Tyr Ile Asn Ser Thr Arg Asn Pro Val Ala Ser 
465                 470                 475                 480 


Ile Leu Pro Thr Ile Ser Ile Thr Lys Tyr Lys Pro Ala Pro Val Val 
                485                 490                 495     


Ala Tyr Phe Ser Ser Arg Gly Pro Ala Tyr Asn Thr Pro Asn Leu Leu 
            500                 505                 510         


Lys Pro Asp Ile Thr Ala Pro Gly Val Ala Ile Leu Ala Ala Trp Pro 
        515                 520                 525             


Gly Asn Asp Thr Ser Glu Ala Leu Pro Gly Gln Lys Pro Pro Ile Phe 
    530                 535                 540                 


Asn Leu Leu Ser Gly Thr Ser Met Ser Cys Pro His Val Ser Gly Ile 
545                 550                 555                 560 


Ala Ala Thr Val Lys Ala Val Asn Pro Thr Trp Ser Pro Ser Ala Val 
                565                 570                 575     


Lys Ser Ala Ile Met Thr Thr Ala Ile Gln Thr Asn Asn Leu Lys Ala 
            580                 585                 590         


Pro Ile Thr Thr Val Ser Gly Ser Lys Ala Thr Pro Tyr Asp Ile Gly 
        595                 600                 605             


Ala Gly Glu Ala Ser Thr Ser Gly Pro Leu Lys Pro Gly Leu Val Tyr 
    610                 615                 620                 


Glu Thr Asp Val Ala Asp Tyr Leu Gln Phe Leu Cys Ser Val Gly Phe 
625                 630                 635                 640 


Asn Ile Ser Gln Ile Lys Leu Ile Ser Ser Thr Val Pro Lys Asp Phe 
                645                 650                 655     


Ser Cys Pro Lys Asn Ser Ser Ser Glu Leu Val Ser Asn Met Asn Tyr 
            660                 665                 670         


Pro Ser Ile Ala Thr Ser Ser Leu Lys Glu Asn Glu Pro Lys Lys Val 
        675                 680                 685             


Thr Arg Thr Val Thr Asn Thr Gly Glu Glu Ala Ser Val Tyr Thr Ala 
    690                 695                 700                 


Ile Ile Glu Ala Pro Lys Gly Leu Glu Val Gln Val Ile Pro Thr Lys 
705                 710                 715                 720 


Leu Glu Phe Thr Asn Lys Arg Lys Lys Val Ser Tyr Asp Val Ser Phe 
                725                 730                 735     


Lys Ala Ser Ser Thr Ser Lys Glu Asp Leu Phe Gly Ser Ile Thr Trp 
            740                 745                 750         


Thr Asn Gly Lys Tyr Lys Val Arg Ser Pro Phe Val Val Ser Ser Asn 
        755                 760                 765             


<210>  7
<211>  2307
<212>  DNA
<213>  Nicotiana tabacum

<400>  7
atgaaaggcc tttttttgtt catatgcttc tctcttttca ttgtctcttt cataatagaa       60

gccgactcag cttctcaatc acaaaacaat ggcatttata ttgtttatat gggtgctgcg      120

gcttcatcta acggtggtac cagacatgat caagcgcagc ttatcagctc cttgatcaga      180

aggaacaaga atgcagtggt acacagctac aagaatggtt tctcaggatt tgcggcacgt      240

ttatcagaag ctgaagctaa atcgatggct caaagacctg gagttgtctc tgtatttcct      300

gatccagtac tgcaactcca cactacacat tcatgggatt tcttgaagta tcaaactgat      360

gaaaaaatca attcaagtcc aagctctggt tctgattcat cattaattgg agctgatacc      420

ataattggaa tcttggatac gggtatatgg ccagaatcag agagtttcaa tgacaaggat      480

atgggtccaa ttccagcccg gtggaatgga acttgcatgg atggtcaaga ttttggctct      540

tccaattgca acaagaagat agttggtgca agattttatg aggagtctga tgacagtgga      600

ataaaaatca ctggatcagc cagggacgag aacggacatg gtactcacgt tgcatccact      660

gcagctggga gccctgttgc aggtgcatcc tactatggcc tagctgcagg gactgcaaca      720

ggtggatctc cgggttccag gatcgccatg tatcgtgtct gtactacttt tggatgccgt      780

ggatcagcta tcatgaaagc attcgatgat gcaattgcag atggggttga tgttttatct      840

ctatcactcg gttcatcacc tggacttgaa cctgattttc caaccaatcc tattgccata      900

ggagcatttc atgccgtaga aaagggcatt gttgttgttt gctctgctgg aaatagtggc      960

cctggcccaa aaactgttgt caatacagct ccttggattc ttactgttgc agccaccacc     1020

attgatcgtg acttcgagac agatgttctc ttgggtggaa acaagttgat taagggtgga     1080

ggtataaact ttggtaacat gacaaaatca acagtctacc ccttgattca tggcaattca     1140

accaaatcaa acgataatgt ttctgaggca gatgcaagga gttgtgttcc tggttcatta     1200

gatgaaaaca aagtcaaggg gaagattgtt ctttgtgaaa atcttgatga tggcgaatat     1260

tttcccagtg acaagctaga cgaagtgaag agtcgaggtg gagttggatt tatactaata     1320

gatgatgatg aaagaactgt ggcacctaaa ttcaaagcct tcccagcggg tgtagtctct     1380

aaaaaggatg gtactgagat cctcgcctac attaactcga caaggaatcc agttgcatca     1440

attttgccaa ctatttccat aacaaagtac aaaccagctc cagttgttgc ttacttctca     1500

tcaagaggtc ctgcatacaa tacacctaac ctcctcaaac cagatattac agcaccaggg     1560

gttgccattc ttgctgcttg gcctggaaat gacacgagtg aggctctccc cggccaaaaa     1620

ccaccaattt tcaacctact ctcaggcact tccatgtcct gccctcacgt ttctggcatt     1680

gctgcaacgg tcaaagcagt gaacccaacc tggagtcctt cagctgtcaa atcagctatt     1740

atgaccacag ctattcagac aaacaatttg aaggctccaa tcactacagt ctcaggatcc     1800

aaagcaacac catatgacat aggagcagga gaagcaagca cttcaggtcc attaaaacca     1860

ggtctagtct acgagacaga tgtcgccgac tacttgcagt tcctctgttc tgttggcttt     1920

aacatatcac agataaagct gatctcaagt acagttccta aggacttttc atgcccaaaa     1980

aactcaagct ctgaattggt ttctaacatg aattatcctt caatagctac ttctagtctc     2040

aaagaaaacg agcccaagaa agttactaga actgttacaa atactggtga agaagcatca     2100

gtatatactg caattattga ggcaccaaaa ggattggaag tccaagtgat tccaactaaa     2160

ttggaattta caaataaaag gaagaaagta agctatgatg tatctttcaa agcctcatct     2220

acctcaaagg aagatctgtt tggatcaatt acttggacaa atggtaagta caaagtccgg     2280

agtccatttg tcgtaagtag caactaa                                         2307


<210>  8
<211>  783
<212>  PRT
<213>  Solanum lycopersicum

<400>  8

Met Arg Asp Ile Val Leu Phe Phe Cys Phe Leu Leu Phe Leu Leu Ser 
1               5                   10                  15      


Leu Leu Arg Glu Thr Asn Ala Val Ser Gln Glu Lys Asn Asn Gly Val 
            20                  25                  30          


Tyr Ile Val Tyr Met Gly Ala Ala Asp Ser Ser Asn Asp Gly Thr Lys 
        35                  40                  45              


Asn Gln Gln Ala Glu Leu Met Ser Ser Leu Ile Lys Arg Lys Lys Asp 
    50                  55                  60                  


Ala Val Val His Ser Tyr Asn Asn Gly Phe Ser Gly Phe Ala Ala Arg 
65                  70                  75                  80  


Leu Ser Glu Ala Glu Ala Lys Ser Ile Ala Gln Lys Pro Gly Val Ile 
                85                  90                  95      


Ser Val Phe Pro Asp Pro Ile Leu Gln Leu His Thr Thr Arg Ser Trp 
            100                 105                 110         


Asp Phe Leu Gln Tyr Gln Thr Glu Val Glu Ser Ser Ser Gly Pro Ile 
        115                 120                 125             


Ser Gly Ser Asp Asn Ala Ser Pro Lys Gly Val Asp Thr Ile Ile Gly 
    130                 135                 140                 


Ile Leu Asp Thr Gly Ile Trp Pro Glu Ser Glu Ser Phe Ser Asp Asn 
145                 150                 155                 160 


Asp Met Ser Glu Val Pro Ser Lys Trp Lys Gly Thr Cys Met Gly Ser 
                165                 170                 175     


His Asp Ser Ile Ser Phe Lys Cys Asn Lys Lys Leu Val Gly Ala Arg 
            180                 185                 190         


Phe Tyr Asp Asp Ser Asp Glu Asp Gly Val Arg Pro Phe Gly Ser Ala 
        195                 200                 205             


Arg Asp Asp Asn Gly His Gly Thr His Val Ala Ser Thr Ala Ala Gly 
    210                 215                 220                 


Ser Leu Ile Ser Gly Ala Ser Tyr Tyr Gly Leu Ala Ser Gly Thr Ala 
225                 230                 235                 240 


Lys Gly Gly Ser Pro Gly Ser Arg Ile Ala Met Tyr Arg Val Cys Thr 
                245                 250                 255     


Ala Asp Gly Cys His Gly Ser Ala Ile Met Lys Ala Phe Asp Asp Ala 
            260                 265                 270         


Ile Ala Asp Gly Val Asp Val Leu Ser Leu Ser Leu Gly Ser Ser Ser 
        275                 280                 285             


Gly Leu Glu Val Glu Phe Ser Arg Asp Pro Ile Ala Ile Gly Ala Phe 
    290                 295                 300                 


His Ala Val Glu Lys Gly Ile Leu Val Ser Cys Ser Ala Gly Asn Asp 
305                 310                 315                 320 


Gly Pro Gly Pro Ala Thr Val Val Asn Val Ala Pro Trp Ile Leu Thr 
                325                 330                 335     


Val Ala Ala Thr Thr Ile Asp Arg Asp Phe Glu Thr Asp Ile Val Leu 
            340                 345                 350         


Gly Gly Asn Lys Leu Ile Lys Gly Gly Gly Ile Ser Leu Gly Asn Leu 
        355                 360                 365             


Thr Arg Ser Pro Val Tyr Pro Leu Ile Ser Gly Asp Leu Ala Lys Ser 
    370                 375                 380                 


Ser Asn Asn Val Val Met Glu Lys Gly Ala Arg Tyr Cys Tyr Pro Asn 
385                 390                 395                 400 


Ser Leu Asp Glu Thr Lys Val Lys Gly Lys Ile Val Leu Cys Asp Asn 
                405                 410                 415     


Arg Asp Gly Tyr Phe Ser Leu Thr Glu Lys Leu Thr Glu Val Lys Lys 
            420                 425                 430         


Lys Gly Gly Ile Gly Phe Ile Leu Ile Asp Asp Asn Ala Arg Thr Val 
        435                 440                 445             


Ala Pro Lys Phe Asn Ser Phe Pro Ala Ala Val Val Thr Glu Lys Asp 
    450                 455                 460                 


Ser Asn Glu Ile Leu Ser Tyr Ile Asn Ser Thr Lys Lys Pro Val Ala 
465                 470                 475                 480 


Ser Val Leu Pro Thr Val Thr Ile Ala Asn Tyr Lys Pro Ala Pro Leu 
                485                 490                 495     


Val Ala Tyr Phe Ser Ser Arg Gly Pro Thr Tyr Asn Thr His Asn Leu 
            500                 505                 510         


Leu Lys Pro Asp Ile Thr Ala Pro Gly Val Ala Ile Leu Ala Ala Trp 
        515                 520                 525             


Pro Gly Asn Asp Thr Thr Glu Ala Val Ala Gly Gln Ala Leu Pro Leu 
    530                 535                 540                 


Tyr Asn Ile Ile Ser Gly Thr Ser Met Ser Cys Pro His Val Ser Gly 
545                 550                 555                 560 


Ile Ala Ala Leu Val Lys Ala Gln Asn Pro Ser Trp Ser Pro Ser Ala 
                565                 570                 575     


Ile Arg Ser Ala Ile Met Thr Ser Ala Leu Gln Thr Asn Asn Leu Lys 
            580                 585                 590         


Ala Pro Ile Thr Thr Val Ser Gly Ser Val Ala Thr Pro Tyr Asp Ile 
        595                 600                 605             


Gly Ala Gly Glu Ala Ser Pro Ser Leu Ala Leu Asn Pro Gly Leu Val 
    610                 615                 620                 


Tyr Glu Thr Asn Thr Ala Asp Tyr Leu Gln Tyr Leu Cys Ser Val Gly 
625                 630                 635                 640 


Tyr Asp Lys Ser Lys Ile Lys Leu Ile Ser Asn Thr Val Pro Asp Asp 
                645                 650                 655     


Phe Ser Cys Pro Thr Asn Ser Ser Ser Glu Ser Val Ser Gln Met Asn 
            660                 665                 670         


Tyr Pro Ser Ile Ala Val Ser Asn Ile Lys Glu Asn Glu Ile Lys Lys 
        675                 680                 685             


Val Thr Arg Thr Val Thr Asn Val Gly Gln Asp Asp Ala Thr Tyr Thr 
    690                 695                 700                 


Ala Ser Ile Lys Ala Pro Val Gly Leu Glu Val Gln Val Thr Pro Asn 
705                 710                 715                 720 


Lys Leu Val Phe Thr Asn Asn Ser Lys Lys Leu Ser Tyr Glu Met Ser 
                725                 730                 735     


Phe Lys Ala Ser Ser Lys Pro Lys Glu Asp Leu Phe Gly Ser Ile Thr 
            740                 745                 750         


Trp Thr Asn Gly Lys Tyr Lys Val Arg Ser Pro Phe Val Ile Ser Thr 
        755                 760                 765             


Asn Ser Gln Gly Glu His Ser Lys Thr Ala Asp Arg Arg Ser Asn 
    770                 775                 780             


<210>  9
<211>  2352
<212>  DNA
<213>  Solanum lycopersicum

<400>  9
atgagagaca ttgttctgtt tttttgcttc cttttatttt tactctcttt gcttagagaa       60

actaatgcag tttctcaaga aaaaaacaat ggtgtttata ttgtttacat gggtgctgct      120

gattcgtcga acgatggcac gaaaaatcag caagcagaac taatgagctc attgataaaa      180

aggaaaaagg atgcagttgt acacagttac aacaatggtt tctcaggatt cgcagcgcgt      240

ttatcagaag ctgaggctaa atctattgct caaaaacctg gagttatatc agtattccct      300

gatccaatat tgcaactaca cacaacgcgt tcgtgggact ttttgcaata tcaaactgaa      360

gtagaaagca gttctggtcc aatatctggt tctgataacg cgtcaccaaa aggcgttgat      420

actataattg gaatcctgga tacaggaata tggcctgaat cagagagttt tagtgataat      480

gatatgagtg aagttccatc taagtggaaa ggaacttgta tgggaagtca tgattccatc      540

tctttcaaat gcaacaagaa gttagttggt gcaaggttct atgatgactc tgatgaggat      600

ggtgtaagac cttttggttc agctagggat gataatggac atggaactca tgttgcatct      660

acagcagctg ggagtttgat ttcaggagca tcttattatg gtttggcttc tgggacagca      720

aagggtggat ccccgggttc aagaatagcc atgtatcgtg tctgcacggc tgatggatgt      780

cacggatcag ctataatgaa agcatttgat gatgcaattg cagatggggt tgatgtttta      840

tcgctatcac ttggttcatc atctggtctt gaagtcgagt tttctagaga tcctatagct      900

attggagcat tccatgctgt tgaaaaggga attcttgttt cctgttctgc tggaaatgat      960

ggccctggtc cggcaactgt tgtcaatgtt gcaccttgga ttctcactgt tgcagctact     1020

acaattgacc gtgacttcga gacagatatt gtcttaggtg gaaacaagtt gataaaggga     1080

ggaggtataa gtttaggtaa cttgacaaga tctccagtat acccgttgat tagtggcgat     1140

ttagccaaat ccagcaataa tgttgttatg gagaaaggtg caaggtattg ttatccgaat     1200

tcattagatg aaaccaaagt taaggggaaa attgttctct gtgataatcg cgacggatac     1260

ttttcactta ctgagaaact aacagaagtg aagaagaaag gtggcattgg atttatacta     1320

atagatgata atgcaagaac tgtggcccca aaattcaatt cctttccagc agctgttgta     1380

actgaaaagg atagcaatga gatcctttct tacatcaact caacaaagaa accagttgca     1440

tcagttctgc caactgttac catagctaac tacaaaccag ctcctcttgt ggcttacttc     1500

tcatcaaggg gtcctacata caacacacat aatctcctca aaccagatat tacagcacca     1560

ggtgttgcaa ttctcgcggc ttggcctgga aacgacacaa cagaggctgt cgctggccag     1620

gcgttaccac tttacaacat aatatcaggg acttccatgt cctgccctca tgtttctggt     1680

attgccgcgt tagtcaaggc gcaaaatcct tcttggagtc cttcagcaat cagatcagct     1740

attatgacct cagctttaca gactaacaat ttgaaggctc caatcacaac agtctctgga     1800

tccgttgcaa caccatacga cataggagct ggagaagcaa gcccttcatt ggcacttaat     1860

ccaggattgg tctacgagac taacaccgca gactacttgc agtacctatg ctcagttggc     1920

tacgataaat caaagataaa actcatttca aatacagttc ctgatgattt ttcatgtccc     1980

accaactcaa gttctgaatc cgtctcacaa atgaactacc cttccattgc tgtttcaaat     2040

atcaaagaaa atgaaatcaa gaaagtaaca agaactgtaa ctaacgtagg acaagacgac     2100

gcaacataca cagcaagtat aaaggcacca gttggtttgg aagtccaagt gaccccgaat     2160

aaattggtat ttacaaataa tagcaagaag ttgagctatg aaatgtcttt caaagcttca     2220

tctaaaccaa aggaagactt gtttggatca attacatgga caaatggtaa atacaaagtc     2280

cgaagtccat tcgttatatc tactaattca caaggtgaac actccaaaac agcagatcgc     2340

agatcaaact ag                                                         2352


<210>  10
<211>  773
<212>  PRT
<213>  Solanum tuberosum

<400>  10

Met Lys Val Ile Val Leu Phe Phe Cys Phe Phe Leu Leu Leu Leu Ser 
1               5                   10                  15      


Phe Leu Arg Glu Thr Asn Ala Val Ser Gln Glu Lys Asn Asn Gly Val 
            20                  25                  30          


Tyr Ile Val Tyr Met Gly Ala Ala Asp Ser Ser Asn Asp Gly Thr Lys 
        35                  40                  45              


Asn Gln Arg Ala Glu Leu Met Ser Ser Leu Ile Arg Arg Lys Lys Asp 
    50                  55                  60                  


Ala Val Val His Ser Tyr Ser Asn Gly Phe Ser Gly Phe Ala Ala Arg 
65                  70                  75                  80  


Leu Ser Glu Ala Glu Ala Lys Ser Ile Ala Gln Lys Pro Gly Val Ile 
                85                  90                  95      


Ser Val Phe Pro Asp Pro Ile Leu Gln Leu His Thr Thr Arg Ser Trp 
            100                 105                 110         


Asp Phe Leu Gln Tyr Gln Thr Glu Val Glu Ser Ser Ser Gly Pro Ile 
        115                 120                 125             


Ser Gly Ser Asp Asn Ala Ser Pro Lys Gly Val Asp Thr Ile Ile Gly 
    130                 135                 140                 


Ile Leu Asp Thr Gly Ile Trp Pro Glu Ser Glu Ser Phe Ser Asp Asn 
145                 150                 155                 160 


Asp Met Ser Glu Val Pro Ser Lys Trp Lys Gly Thr Cys Met Ala Ser 
                165                 170                 175     


His Asp Ser Ile Ser Phe Lys Cys Asn Lys Lys Leu Val Gly Ala Arg 
            180                 185                 190         


Phe Tyr Asp Asp Ser Asp Glu Asp Gly Val Arg Pro Ser Gly Ser Ala 
        195                 200                 205             


Arg Asp Glu Asn Gly His Gly Thr His Val Ala Ser Thr Ala Ala Gly 
    210                 215                 220                 


Ser Pro Ile Ser Gly Ala Ser Tyr Tyr Gly Leu Ala Ser Gly Thr Ala 
225                 230                 235                 240 


Lys Gly Gly Ser Pro Gly Ser Arg Ile Ala Met Tyr Arg Val Cys Met 
                245                 250                 255     


Thr Asp Gly Cys His Gly Ser Ala Ile Met Lys Ala Phe Asp Asp Ala 
            260                 265                 270         


Ile Ala Asp Gly Val Asp Val Leu Ser Leu Ser Leu Gly Ser Ser Ser 
        275                 280                 285             


Gly Leu Glu Val Glu Phe Ser Ser Asp Pro Ile Ala Ile Gly Ala Phe 
    290                 295                 300                 


His Ala Val Glu Lys Gly Ile Leu Val Ser Cys Ser Ala Gly Asn Asp 
305                 310                 315                 320 


Gly Pro Gly Pro Ala Thr Val Val Asn Val Ala Pro Trp Ile Leu Thr 
                325                 330                 335     


Val Ala Ala Thr Thr Ile Asp Arg Asp Phe Glu Thr Asp Ile Val Leu 
            340                 345                 350         


Gly Gly Asn Lys Leu Ile Lys Gly Gly Gly Ile Ser Leu Gly Asn Leu 
        355                 360                 365             


Thr Arg Ser Pro Val Tyr Pro Leu Ile Ser Gly Asp Leu Ala Lys Ser 
    370                 375                 380                 


Gly Asn Thr Val Val Ser Glu Lys Asn Ala Arg Phe Cys Asn Pro Asn 
385                 390                 395                 400 


Ser Leu Asp Gly Thr Lys Val Lys Gly Lys Val Val Leu Cys Asp Asn 
                405                 410                 415     


Arg Asp Gly Tyr Tyr Ser Leu Thr Glu Lys Leu Thr Glu Val Lys Ser 
            420                 425                 430         


Lys Gly Gly Ile Gly Phe Ile Val Val Asp Asp Asn Ala Arg Thr Val 
        435                 440                 445             


Ala Pro Lys Phe Lys Ser Phe Pro Ala Ala Val Val Thr Glu Lys Asp 
    450                 455                 460                 


Ser Asn Glu Ile Leu Ser Tyr Ile Asn Ser Thr Lys Lys Pro Val Ala 
465                 470                 475                 480 


Ser Val Leu Pro Thr Val Thr Ile Ala Asn Tyr Lys Pro Ala Pro Leu 
                485                 490                 495     


Val Ala Tyr Phe Ser Ser Arg Gly Pro Thr Tyr Asn Thr His Asn Leu 
            500                 505                 510         


Leu Lys Pro Asp Ile Thr Ala Pro Gly Val Ala Ile Leu Ala Ala Trp 
        515                 520                 525             


Pro Gly Asn Asp Thr Asn Glu Ala Val Ala Gly Gln Ala Pro Pro Leu 
    530                 535                 540                 


Tyr Asn Ile Ile Ser Gly Thr Ser Met Ser Cys Pro His Val Ser Gly 
545                 550                 555                 560 


Ile Ala Ala Leu Val Lys Ala Gln Asn Pro Ser Trp Ser Pro Ser Ala 
                565                 570                 575     


Ile Lys Ser Ala Ile Met Thr Ser Ala Leu Gln Thr Asn Asn Leu Lys 
            580                 585                 590         


Ala Pro Ile Thr Thr Val Ser Gly Ser Val Ala Thr Pro Tyr Asp Ile 
        595                 600                 605             


Gly Ala Gly Glu Ala Ser Pro Ser Leu Ala Leu Asn Pro Gly Leu Val 
    610                 615                 620                 


Tyr Glu Thr Asn Thr Ala Asp Tyr Leu Gln Tyr Leu Cys Ser Val Gly 
625                 630                 635                 640 


Tyr Asp Lys Ser Lys Ile Lys Leu Ile Ser Asn Thr Val Pro Asn Asp 
                645                 650                 655     


Phe Ser Cys Pro Thr Asn Ser Ser Ser Glu Ser Val Ser Gln Met Asn 
            660                 665                 670         


Tyr Pro Ser Ile Ala Val Ser Asn Ile Lys Glu Asn Glu Ile Lys Lys 
        675                 680                 685             


Val Thr Arg Thr Val Thr Asn Val Gly Gln Glu Asp Ala Thr Tyr Thr 
    690                 695                 700                 


Ala Ser Ile Lys Ala Pro Val Gly Leu Glu Val Gln Val Thr Pro Asn 
705                 710                 715                 720 


Lys Leu Val Phe Thr Asn Asn Ser Lys Lys Leu Ser Tyr Glu Val Ser 
                725                 730                 735     


Phe Lys Ala Ser Ser Lys Pro Lys Glu Asp Leu Phe Gly Ser Ile Thr 
            740                 745                 750         


Trp Thr Asn Gly Lys Tyr Lys Val Arg Ser Pro Phe Val Val Ser Thr 
        755                 760                 765             


Asn Ser Gln Gly Val 
    770             


<210>  11
<211>  2322
<212>  DNA
<213>  Solanum tuberosum

<400>  11
atgaaagtca ttgttctgtt tttttgcttc tttttattat tactctcttt tcttagagaa       60

actaatgcag tttctcaaga aaaaaacaat ggtgtataca ttgtttacat gggcgctgct      120

gattcgtcga acgatggcac gaaaaatcag cgagcagaac ttatgagctc tttgataaga      180

agaaaaaagg atgcagttgt acacagttac agcaatggtt tctcaggatt cgcagcgcgt      240

ttatcagaag ctgaggctaa atccattgct caaaaacctg gagttatatc agtattccct      300

gatccaatat tgcaactcca cacaacgcgt tcgtgggact ttttgcaata tcaaactgaa      360

gtagaaagca gttctggtcc aatatcaggt tctgataacg cgtcaccaaa aggcgttgat      420

actataattg gaatcttgga tacaggaata tggcctgaat cagagagttt tagtgataat      480

gatatgagtg aagttccatc taagtggaaa ggaacttgta tggcaagtca tgattccatc      540

tctttcaaat gcaacaagaa gttagttggt gcaaggttct atgatgactc tgatgaggat      600

ggtgtaagac cttctggttc agctagggat gagaatggac atggaactca tgttgcatct      660

acagcagctg ggagtccgat ttcaggagca tcttattatg gtttggcttc tgggaccgcg      720

aagggtggat ccccgggttc aagaatagcc atgtatcgtg tctgcatgac tgatggatgt      780

cacggatcag ctataatgaa agcatttgat gatgcaattg cagatggggt tgatgtttta      840

tcgctatcac ttggttcatc atctggtctt gaagttgagt tttcgagtga tcctatagct      900

attggagcat tccatgctgt tgaaaaggga attcttgttt cctgttctgc tggaaatgat      960

ggccctggtc cggcaactgt tgtcaacgtc gcgccttgga ttctcacagt tgcagctact     1020

acaattgacc gtgacttcga gacagatatt gtcttaggtg gaaacaagtt gattaagggt     1080

ggaggtataa gtcttggtaa tttgacaaga tctccagtat acccgttgat tagtggcgat     1140

ttagccaagt ccggcaatac tgttgtttcg gagaaaaatg caaggttttg taatccgaat     1200

tcattagatg gaaccaaagt taaggggaaa gttgttcttt gtgataatcg cgacggatac     1260

tattcactta ctgagaaact aacagaagtg aagagcaaag gtggcattgg atttatagta     1320

gtagatgata atgcaagaac tgtggcacct aaattcaaat cctttccagc agctgttgta     1380

actgaaaagg atagcaatga gatcctttct tacatcaact caacaaagaa accagttgca     1440

tcagttctgc caactgttac catagctaac tacaaaccag ctcctcttgt ggcttacttc     1500

tcatcaaggg gtcctacata caacacacat aatctcctca aaccagatat tacagcacca     1560

ggtgttgcaa ttctcgcggc ttggcctgga aacgacacaa acgaggctgt cgctggccag     1620

gcgccaccac tttacaacat aatatcaggg acttccatgt cctgccctca tgtttctggt     1680

attgccgcat tagtcaaggc gcaaaatcct tcttggagtc cttcagcaat caaatcagct     1740

atcatgacct cagctttaca gactaacaat ttgaaggctc caatcacaac agtctccggc     1800

tccgttgcaa caccatacga cataggagct ggagaagcaa gcccttcatt ggcacttaat     1860

ccaggattgg tctacgagac taacactgca gactacttgc agtacctatg ctcagttggc     1920

tacgataaat caaagataaa actcatctca aatactgttc ctaatgattt ttcatgtccc     1980

accaactcaa gttctgaatc cgtctcacaa atgaactacc cttccattgc tgtttcaaat     2040

atcaaagaaa atgaaatcaa gaaagtaaca agaactgtaa ctaacgtagg acaagaagac     2100

gcaacataca cagcaagtat aaaagcacca gttggtttgg aagtccaagt gaccccgaat     2160

aaattggtat ttacaaataa tagcaagaag ttgagctatg aagtgtcttt caaagcttca     2220

tctaaaccaa aggaagactt gtttggatca attacatgga caaatggtaa atacaaagtc     2280

cgaagtccat tcgttgtatc tactaattca caaggtgtct ga                        2322


<210>  12
<211>  769
<212>  PRT
<213>  Arabidopsis thaliana

<400>  12

Met Lys Gly Ile Thr Phe Phe Thr Pro Phe Leu Ser Phe Leu Tyr Leu 
1               5                   10                  15      


Leu Cys Ile Leu Phe Met Thr Glu Thr Glu Ala Gly Ser Arg Asn Gly 
            20                  25                  30          


Asp Gly Val Tyr Ile Val Tyr Met Gly Ser Ala Ser Ser Ala Ala Asn 
        35                  40                  45              


Ala Asn Arg Ala Gln Ile Leu Ile Asn Thr Met Phe Lys Arg Arg Ala 
    50                  55                  60                  


Asn Asp Leu Leu His Thr Tyr Lys His Gly Phe Ser Gly Phe Ala Ala 
65                  70                  75                  80  


Arg Leu Thr Ala Glu Glu Ala Lys Val Ile Ala Lys Lys Pro Gly Val 
                85                  90                  95      


Val Ser Val Phe Pro Asp Pro His Phe Gln Leu His Thr Thr His Ser 
            100                 105                 110         


Trp Asp Phe Leu Lys Tyr Gln Thr Ser Val Lys Val Asp Ser Gly Pro 
        115                 120                 125             


Pro Ser Ser Ala Ser Asp Gly Ser Tyr Asp Ser Ile Val Gly Ile Leu 
    130                 135                 140                 


Asp Thr Gly Ile Trp Pro Glu Ser Glu Ser Phe Asn Asp Lys Asp Met 
145                 150                 155                 160 


Gly Pro Ile Pro Ser Arg Trp Lys Gly Thr Cys Met Glu Ala Lys Asp 
                165                 170                 175     


Phe Lys Ser Ser Asn Cys Asn Arg Lys Ile Ile Gly Ala Arg Tyr Tyr 
            180                 185                 190         


Lys Asn Pro Asp Asp Asp Ser Glu Tyr Tyr Thr Thr Arg Asp Val Ile 
        195                 200                 205             


Gly His Gly Ser His Val Ser Ser Thr Ile Ala Gly Ser Ala Val Glu 
    210                 215                 220                 


Asn Ala Ser Tyr Tyr Gly Val Ala Ser Gly Thr Ala Lys Gly Gly Ser 
225                 230                 235                 240 


Gln Asn Ala Arg Ile Ala Met Tyr Lys Val Cys Asn Pro Gly Gly Cys 
                245                 250                 255     


Thr Gly Ser Ser Ile Leu Ala Ala Phe Asp Asp Ala Ile Ala Asp Gly 
            260                 265                 270         


Val Asp Val Leu Ser Leu Ser Leu Gly Ala Pro Ala Tyr Ala Arg Ile 
        275                 280                 285             


Asp Leu Asn Thr Asp Pro Ile Ala Ile Gly Ala Phe His Ala Val Glu 
    290                 295                 300                 


Gln Gly Ile Leu Val Ile Cys Ser Ala Gly Asn Asp Gly Pro Asp Gly 
305                 310                 315                 320 


Gly Thr Val Thr Asn Thr Ala Pro Trp Ile Met Thr Val Ala Ala Asn 
                325                 330                 335     


Thr Ile Asp Arg Asp Phe Glu Ser Asp Val Val Leu Gly Gly Asn Lys 
            340                 345                 350         


Val Ile Lys Gly Glu Gly Ile His Phe Ser Asn Val Ser Lys Ser Pro 
        355                 360                 365             


Val Tyr Pro Leu Ile His Gly Lys Ser Ala Lys Ser Ala Asp Ala Ser 
    370                 375                 380                 


Glu Gly Ser Ala Arg Ala Cys Asp Ser Asp Ser Leu Asp Gln Glu Lys 
385                 390                 395                 400 


Val Lys Gly Lys Ile Val Leu Cys Glu Asn Val Gly Gly Ser Tyr Tyr 
                405                 410                 415     


Ala Ser Ser Ala Arg Asp Glu Val Lys Ser Lys Gly Gly Thr Gly Cys 
            420                 425                 430         


Val Phe Val Asp Asp Arg Thr Arg Ala Val Ala Ser Ala Tyr Gly Ser 
        435                 440                 445             


Phe Pro Thr Thr Val Ile Asp Ser Lys Glu Ala Ala Glu Ile Phe Ser 
    450                 455                 460                 


Tyr Leu Asn Ser Thr Lys Asp Pro Val Ala Thr Ile Leu Pro Thr Ala 
465                 470                 475                 480 


Thr Val Glu Lys Phe Thr Pro Ala Pro Ala Val Ala Tyr Phe Ser Ser 
                485                 490                 495     


Arg Gly Pro Ser Ser Leu Thr Arg Ser Ile Leu Lys Pro Asp Ile Thr 
            500                 505                 510         


Ala Pro Gly Val Ser Ile Leu Ala Ala Trp Thr Gly Asn Asp Ser Ser 
        515                 520                 525             


Ile Ser Leu Glu Gly Lys Pro Ala Ser Gln Tyr Asn Val Ile Ser Gly 
    530                 535                 540                 


Thr Ser Met Ala Ala Pro His Val Ser Ala Val Ala Ser Leu Ile Lys 
545                 550                 555                 560 


Ser Gln His Pro Thr Trp Gly Pro Ser Ala Ile Arg Ser Ala Ile Met 
                565                 570                 575     


Thr Thr Ala Thr Gln Thr Asn Asn Asp Lys Gly Leu Ile Thr Thr Glu 
            580                 585                 590         


Thr Gly Ala Thr Ala Thr Pro Tyr Asp Ser Gly Ala Gly Glu Leu Ser 
        595                 600                 605             


Ser Thr Ala Ser Met Gln Pro Gly Leu Val Tyr Glu Thr Thr Glu Thr 
    610                 615                 620                 


Asp Tyr Leu Asn Phe Leu Cys Tyr Tyr Gly Tyr Asn Val Thr Thr Ile 
625                 630                 635                 640 


Lys Ala Met Ser Lys Ala Phe Pro Glu Asn Phe Thr Cys Pro Ala Asp 
                645                 650                 655     


Ser Asn Leu Asp Leu Ile Ser Thr Ile Asn Tyr Pro Ser Ile Gly Ile 
            660                 665                 670         


Ser Gly Phe Lys Gly Asn Gly Ser Lys Thr Val Thr Arg Thr Val Thr 
        675                 680                 685             


Asn Val Gly Glu Asp Gly Glu Ala Val Tyr Thr Val Ser Val Glu Thr 
    690                 695                 700                 


Pro Pro Gly Phe Asn Ile Gln Val Thr Pro Glu Lys Leu Gln Phe Thr 
705                 710                 715                 720 


Lys Asp Gly Glu Lys Leu Thr Tyr Gln Val Ile Val Ser Ala Thr Ala 
                725                 730                 735     


Ser Leu Lys Gln Asp Val Phe Gly Ala Leu Thr Trp Ser Asn Ala Lys 
            740                 745                 750         


Tyr Lys Val Arg Ser Pro Ile Val Ile Ser Ser Glu Ser Ser Arg Thr 
        755                 760                 765             


Asn 
    


<210>  13
<211>  2310
<212>  DNA
<213>  Arabidopsis thaliana

<400>  13
atgaaaggca ttacattctt cacacccttt ttatcatttc tatatctctt atgcatcttg       60

tttatgacag aaactgaagc tgggtcgaga aatggtgatg gggtctacat tgtctacatg      120

ggatcagctt cctctgctgc aaacgctaat agagctcaaa tactcataaa caccatgttt      180

aaaaggagag caaacgatct tctccacaca tataagcatg gcttctcagg ttttgcagct      240

cgtttgacag cagaagaggc caaggtcata gccaagaaac cgggagtggt ttcagttttt      300

cctgacccac acttccagct tcatacaact cattcatggg actttctcaa gtaccaaaca      360

tcagtaaagg tcgattccgg tccaccttca tcagcctcag atggatcata tgatagcatt      420

gtcggaattc ttgacacagg gatatggcca gagtcagaga gtttcaatga caaagacatg      480

ggtccaattc cgtctcggtg gaaaggtaca tgcatggaag caaaggactt caagtcttcc      540

aactgtaaca gaaagatcat tggagcaaga tactacaaaa atcctgatga tgattcagaa      600

tactatacca caagggatgt catcggtcac ggttctcatg tgtcctccac catagctgga      660

tctgccgtgg agaatgcttc ctactatggt gtagcttccg ggactgcaaa gggaggttca      720

caaaacgcta gaatcgctat gtacaaagta tgcaatccag ggggatgcac tggctcctct      780

atcttagctg ctttcgatga tgcaatcgca gatggagttg atgttctatc tctgtctctt      840

ggagctccag catacgctcg catcgacttg aacactgatc ctattgccat tggagcgttt      900

cacgcggtgg agcaaggaat cttggtgatc tgctctgcgg gtaatgatgg acctgatggc      960

ggtacagtta ctaatactgc accttggata atgaccgttg ctgccaacac tattgataga     1020

gactttgagt ctgatgttgt actaggcggc aataaagtca tcaagggtga aggtatacac     1080

ttttcaaacg ttagtaaatc tcctgtgtat cctctgattc atggcaagtc tgctaagagc     1140

gctgatgcat cagaaggatc agccagggcc tgtgactctg attctctaga tcaagagaag     1200

gtaaaaggga agattgtgtt atgcgagaac gttggtggat catattatgc atcatccgct     1260

agggacgagg tgaagagcaa aggaggtact ggttgcgtct ttgtagatga cagaactaga     1320

gcagttgcta gtgcttatgg tagctttcct actaccgtaa ttgactcaaa ggaagcagct     1380

gagatcttct cctacctcaa ctcaaccaaa gatcctgttg caacaattct tcccactgca     1440

acagttgaaa agttcacacc tgcccctgct gttgcatatt tttcttccag aggaccttca     1500

agcctcacaa gaagcattct caaacctgac attaccgcac caggagtctc gatactcgct     1560

gcatggactg gaaacgactc aagcatttca ctggaaggca agccggcttc tcagtataac     1620

gtcatatcag gaacttccat ggcagctcct catgtttcag ctgttgcatc tctgatcaaa     1680

tcacagcatc ccacatgggg tccatccgcg atcagatcag caattatgac aacagcgact     1740

caaacaaaca acgacaaagg tcttataaca acagaaactg gtgcaacagc cacaccttat     1800

gactctggag caggagaact aagctcaaca gcatcaatgc aaccaggact agtttacgag     1860

actactgaaa ctgactacct gaactttctc tgttactatg gatataacgt aaccacaata     1920

aaggctatgt caaaagcttt tccagagaat tttacttgcc ctgcagattc caacttagac     1980

ttgatctcca ccatcaatta cccgtcaatt ggaatctctg gattcaaagg aaatggtagc     2040

aagacagtta caagaacagt gaccaatgtt ggtgaggacg gtgaggcggt ttacacagtc     2100

agcgtggaaa caccaccagg gtttaacatt caagtgacgc cagaaaaact ccaatttaca     2160

aaagatggtg agaagttgac ataccaggtg atagtgtctg ctactgcttc acttaagcaa     2220

gatgtatttg gggctcttac ttggtctaat gccaagtaca aggtcagaag cccaattgta     2280

attagtagcg agagtagccg cacaaactga                                      2310


<210>  14
<211>  759
<212>  PRT
<213>  Nicotiana benthamiana

<400>  14

Met Ala Asn His Ile Thr Leu Cys Ile Trp Leu Leu Phe Phe Phe Ile 
1               5                   10                  15      


Ser Ile Phe Ser Leu Ala Lys Ser Glu Thr Tyr Ile Ile His Met Asp 
            20                  25                  30          


Leu Ser Ala Met Pro Lys Ala Phe Ser Ser His His Asn Trp Tyr Leu 
        35                  40                  45              


Thr Thr Leu Ser Ser Val Ser Asp Ser Ser Thr Asn His Lys Asp Phe 
    50                  55                  60                  


Leu Ser Ser Lys Leu Val Tyr Ala Tyr Thr Asn Ala Ile His Gly Phe 
65                  70                  75                  80  


Ser Ala Ser Leu Ser Pro Ser Glu Leu Glu Ala Ile Lys Tyr Ser Pro 
                85                  90                  95      


Gly Tyr Val Ser Ser Ile Lys Asp Ile Ser Val Lys Ile Asp Thr Thr 
            100                 105                 110         


His Thr Ser Gln Phe Leu Gly Leu Asn Ser Lys Ser Gly Val Trp Pro 
        115                 120                 125             


Thr Ser Asp Tyr Gly Lys Asp Ile Ile Ile Gly Leu Val Asp Thr Gly 
    130                 135                 140                 


Ile Trp Pro Glu Ser Lys Ser Tyr Ser Asp Asp Gly Ile Ser Glu Val 
145                 150                 155                 160 


Pro Ser Arg Trp Lys Gly Glu Cys Glu Ser Gly Thr Glu Phe Asn Ser 
                165                 170                 175     


Ser Leu Cys Asn Lys Lys Leu Ile Gly Ala Arg Tyr Phe Asn Lys Gly 
            180                 185                 190         


Leu Leu Ala Asn Asn Pro Asn Leu Asn Ile Ser Met Asn Ser Ser Arg 
        195                 200                 205             


Asp Thr Asp Gly His Gly Thr His Thr Ser Ser Thr Ala Ala Gly Ser 
    210                 215                 220                 


Tyr Val Glu Gly Ala Ser Tyr Phe Gly Tyr Ala Thr Gly Thr Ala Ile 
225                 230                 235                 240 


Gly Ile Ala Pro Lys Ala His Val Ala Met Tyr Lys Ala Leu Trp Glu 
                245                 250                 255     


Glu Gly Val Tyr Leu Ser Asp Val Leu Ala Ala Ile Asp Gln Ala Ile 
            260                 265                 270         


Thr Asp Gly Val Asp Val Leu Ser Leu Ser Leu Gly Ile Asp Ala Ile 
        275                 280                 285             


Pro Leu His Glu Asp Pro Val Ala Ile Ala Ala Phe Ala Ala Leu Glu 
    290                 295                 300                 


Lys Gly Ile Phe Val Ser Thr Ser Ala Gly Asn Glu Gly Pro Tyr Tyr 
305                 310                 315                 320 


Glu Thr Leu His Asn Gly Thr Pro Trp Val Leu Thr Val Ala Ala Gly 
                325                 330                 335     


Thr Val Asp Arg Glu Phe Ile Gly Thr Leu Thr Leu Gly Asn Gly Val 
            340                 345                 350         


Ser Val Pro Gly Leu Ser Leu Tyr Pro Gly Asn Ser Ser Ser Ser Glu 
        355                 360                 365             


Ser Ser Leu Val Tyr Val Glu Cys Gln Asp Asp Lys Glu Leu Gln Lys 
    370                 375                 380                 


Asn Ala His Lys Phe Val Val Cys Leu Asp Lys Asn Asp Ser Val Gly 
385                 390                 395                 400 


Glu His Val Tyr Asn Val Arg Asn Ser Lys Val Ala Gly Ala Val Phe 
                405                 410                 415     


Ile Thr Asn Thr Thr Asp Leu Glu Phe Tyr Leu Gln Ser Glu Phe Pro 
            420                 425                 430         


Ala Val Phe Leu Asn Leu Gln Glu Gly Asp Lys Val Leu Glu Tyr Ile 
        435                 440                 445             


Lys Ser Asn Ser Ala Pro Lys Gly Lys Leu Glu Phe Gln Val Thr His 
    450                 455                 460                 


Ile Gly Ala Lys Pro Ala Pro Lys Val Ala Thr Tyr Ser Ser Arg Gly 
465                 470                 475                 480 


Pro Ser Pro Ser Cys Pro Ser Ile Leu Lys Pro Asp Leu Met Ala Pro 
                485                 490                 495     


Gly Ala Leu Ile Leu Ala Ser Trp Pro Gln Gln Ser Pro Val Thr Asp 
            500                 505                 510         


Val Thr Ser Gly Lys Leu Phe Ser Asn Phe Asn Ile Ile Ser Gly Thr 
        515                 520                 525             


Ser Met Ser Cys Pro His Ala Ser Gly Val Ala Ala Leu Leu Lys Ala 
    530                 535                 540                 


Ala His Pro Glu Trp Ser Pro Ala Ala Ile Arg Ser Ala Met Met Thr 
545                 550                 555                 560 


Thr Ser Thr Ala Leu Asp Asn Thr Gln Ser Pro Ile Arg Asp Ile Gly 
                565                 570                 575     


Asn Lys Asn Ala Ala Ala Thr Pro Leu Ala Met Gly Ala Gly His Ile 
            580                 585                 590         


Asp Pro Asn Lys Ala Leu Asp Pro Gly Leu Ile Tyr Asp Ala Thr Pro 
        595                 600                 605             


Gln Asp Tyr Val Asn Leu Leu Cys Ala Leu Asn Phe Thr Ser Lys Gln 
    610                 615                 620                 


Ile Lys Thr Ile Thr Arg Ser Ser Ser Tyr Thr Cys Ser Asn Pro Ser 
625                 630                 635                 640 


Leu Asp Leu Asn Tyr Pro Ser Phe Ile Gly Phe Phe Asn Gly Asn Ser 
                645                 650                 655     


Ser Glu Ser Asp Pro Lys Arg Ile Gln Glu Phe Lys Arg Thr Val Thr 
            660                 665                 670         


Asn Leu Gln Asp Gly Thr Ser Ile Tyr Thr Ala Asn Phe Thr Pro Met 
        675                 680                 685             


Gly Lys Phe Lys Val Ser Val Val Pro Glu Lys Leu Val Phe Lys Glu 
    690                 695                 700                 


Lys Tyr Glu Lys Leu Ser Tyr Lys Leu Arg Ile Glu Gly Pro Ile Val 
705                 710                 715                 720 


Met Asp Asp Asn Val Val Tyr Gly Ser Leu Ser Trp Val Glu Thr Gly 
                725                 730                 735     


Gly Asn Tyr Val Val Arg Ser Pro Ile Val Ala Thr Ser Ile Lys Val 
            740                 745                 750         


Asp Pro Leu Thr Gly His Asn 
        755                 


<210>  15
<211>  2280
<212>  DNA
<213>  Nicotiana benthamiana

<400>  15
atggcaaatc atattacctt gtgtatttgg ttgcttttct tctttatttc tatattttca       60

ctagcaaagt cagaaacata tatcattcat atggatttgt cagccatgcc aaaagctttt      120

tctagccatc ataattggta cttgacaaca ctttcttctg tatcagacag cagtacaaat      180

cacaaagact tcttgtcctc aaaactagtc tatgcttata ctaatgctat acatggtttt      240

agtgcaagtc tctctccttc tgaacttgaa gccataaaat attctccagg ttatgtttct      300

tcaattaagg atatttcagt taaaattgac acaactcaca catcccagtt tcttggccta      360

aactctaagt ctggtgtatg gccaacgtcc gactatggga aagatatcat aattggctta      420

gttgatactg gaatatggcc tgagagtaaa agctatagtg atgatgggat tagtgaagta      480

ccatcaagat ggaaaggaga atgtgaaagt ggtactgagt tcaattcctc tttgtgtaac      540

aagaagctca ttggcgctcg ttacttcaat aaaggcctac ttgccaacaa tccaaatctt      600

aatatttcaa tgaattcttc tagagatacc gatggacatg gaactcacac ttcttctaca      660

gctgcgggaa gttatgttga gggtgcatct tattttggct atgccaccgg tactgctatt      720

ggcatagcgc caaaggctca tgtggctatg tacaaggctc tatgggaaga aggtgtatac      780

ttgtctgatg ttcttgctgc aattgatcaa gcaattacag atggtgtgga tgtcttatcc      840

ttgtcgttag gcatagacgc gattccacta cacgaagatc ctgtggcaat tgccgcattt      900

gctgcattgg agaaaggtat atttgtttcc acctctgcag gaaatgaagg gccttattat      960

gagactttgc acaatggaac accttgggtg ttaactgttg cagctggcac agttgaccgc     1020

gaatttattg gaacattaac tcttggaaat ggagtttcag tccctggttt atcgctatac     1080

cctgggaatt ctagttcaag cgaaagctcc cttgtctatg tcgaatgcca agatgacaag     1140

gaactgcaga aaaatgcaca caaatttgtt gtctgtctcg acaagaatga ttcggttggt     1200

gagcatgtgt acaatgtaag aaattcaaaa gttgctgggg ctgtctttat aactaataca     1260

actgacttgg aattctacct ccaaagcgaa ttcccggctg tgttcttgaa cttacaagag     1320

ggtgataaag ttctagagta cattaagagc aactctgcac ctaaaggaaa acttgaattc     1380

caagttacac atattggtgc taaaccagcg ccaaaagttg ctacctatag ctcaagagga     1440

ccgtcaccga gttgtccaag tatcctcaaa cctgatctca tggctcctgg tgccttaata     1500

cttgcttcat ggccacaaca atcaccagtt actgatgtta cctcaggaaa actttttagt     1560

aacttcaata ttatatctgg tacatcaatg tcatgtccac atgcttctgg tgtagcagca     1620

cttctaaaag ctgcacaccc tgaatggagc cctgcagcca tccgatctgc catgatgacc     1680

acttccactg cgttggacaa cacacagagc cccatccgag acataggtaa caagaatgcg     1740

gctgctactc ctctagccat gggagctggc catatcgatc caaacaaggc gttagatcct     1800

ggacttatct atgatgcaac accacaagat tatgtcaatc tcctctgtgc tctgaacttc     1860

acatccaaac aaataaaaac catcacaaga tcctcatctt atacttgctc caacccatca     1920

ttggacttaa actatccatc cttcattggc tttttcaatg gtaacagcag cgagtcggat     1980

cctaaaagga ttcaagaatt taaaagaaca gtgacaaact tacaagatgg tacatcaata     2040

tatacagcaa acttcactcc aatgggtaaa tttaaagtta gtgttgtacc tgaaaagttg     2100

gttttcaaag agaagtatga aaagctgagc tacaagctta gaatagaagg tccaatagtt     2160

atggatgata atgtggttta tggttctttg agctgggtag aaactggagg taactatgtg     2220

gttagaagtc caattgttgc cacaagcata aaagtggatc ctttgacagg acacaactga     2280


<210>  16
<211>  762
<212>  PRT
<213>  Nicotiana tabacum

<400>  16

Met Ala Asn His Ile Thr Leu Cys Ile Trp Leu Leu Phe Phe Phe Ile 
1               5                   10                  15      


Ser Ile Ile Ser Leu Ala Lys Ser Glu Thr Tyr Ile Ile His Met Asp 
            20                  25                  30          


Phe Ser Ala Met Pro Lys Ala Phe Ser Ser His His Asn Trp Tyr Leu 
        35                  40                  45              


Thr Thr Leu Ser Ser Val Ser Asp Ser Ser Thr Asn Tyr Lys Asp Phe 
    50                  55                  60                  


Leu Ser Ser Lys Leu Val Tyr Ser Tyr Thr Asn Ala Ile His Gly Phe 
65                  70                  75                  80  


Ser Ala Ser Leu Ser Pro Ser Glu Leu Glu Ala Ile Lys Asn Ser Pro 
                85                  90                  95      


Gly Tyr Val Ser Ser Ile Lys Asp Ile Ser Val Lys Ile Asp Thr Thr 
            100                 105                 110         


His Thr Ser Gln Phe Leu Gly Leu Asn Ser Glu Ser Gly Val Trp Pro 
        115                 120                 125             


Thr Ser Glu Tyr Gly Lys Asp Ile Ile Ile Gly Leu Val Asp Thr Gly 
    130                 135                 140                 


Ile Trp Ser Glu Ser Lys Ser Tyr Ser Asp Asp Gly Ile Ser Glu Val 
145                 150                 155                 160 


Pro Ser Arg Trp Lys Gly Glu Cys Glu Ser Gly Thr Glu Phe Asn Ser 
                165                 170                 175     


Ser Leu Cys Asn Lys Lys Leu Ile Gly Ala Arg Tyr Phe Asn Lys Gly 
            180                 185                 190         


Leu Leu Ala Asn Asn Pro Asn Leu Asn Ile Ser Met Asn Ser Ala Arg 
        195                 200                 205             


Asp Thr Asp Gly His Gly Thr His Thr Ser Ser Thr Ala Ala Gly Ser 
    210                 215                 220                 


Tyr Val Glu Gly Ala Ser Tyr Phe Gly Tyr Ala Thr Gly Thr Ala Ile 
225                 230                 235                 240 


Gly Ile Ala Pro Lys Ala His Val Ala Met Tyr Lys Ala Leu Trp Glu 
                245                 250                 255     


Glu Gly Val Tyr Leu Ser Asp Val Leu Ala Ala Ile Asp Gln Ala Ile 
            260                 265                 270         


Thr Asp Gly Val Asp Val Leu Ser Leu Ser Leu Gly Ile Asp Ala Ile 
        275                 280                 285             


Pro Leu His Glu Asp Pro Val Ala Ile Ala Ala Phe Ala Ala Leu Glu 
    290                 295                 300                 


Lys Gly Ile Phe Val Ser Thr Ser Ala Gly Asn Glu Gly Pro Tyr Tyr 
305                 310                 315                 320 


Glu Thr Leu His Asn Gly Thr Pro Trp Val Leu Thr Val Ala Ala Gly 
                325                 330                 335     


Thr Val Asp Arg Glu Phe Ile Gly Thr Leu Thr Leu Gly Asn Gly Val 
            340                 345                 350         


Ser Val Thr Gly Leu Ser Leu Tyr Pro Gly Asn Ser Ser Ser Ser Glu 
        355                 360                 365             


Ser Ser Ile Val Tyr Val Glu Cys Gln Asp Asp Lys Glu Leu Gln Lys 
    370                 375                 380                 


Asn Ala His Lys Phe Val Val Cys Leu Asp Lys Asn Asp Ser Val Gly 
385                 390                 395                 400 


Glu His Val Tyr Asn Val Arg Asn Ser Lys Val Ala Gly Ala Val Phe 
                405                 410                 415     


Ile Thr Asn Thr Thr Asp Leu Glu Phe Tyr Leu Gln Ser Glu Phe Pro 
            420                 425                 430         


Ala Val Phe Leu Asn Leu Gln Glu Gly Asp Lys Val Leu Glu Tyr Ile 
        435                 440                 445             


Lys Ser Asn Ser Ala Pro Lys Gly Lys Leu Glu Phe Gln Val Thr His 
    450                 455                 460                 


Ile Gly Ala Lys Arg Ala Pro Glu Val Ala Thr Tyr Ser Ser Arg Gly 
465                 470                 475                 480 


Pro Ser Pro Ser Cys Pro Ser Ile Leu Lys Pro Asp Leu Met Ala Pro 
                485                 490                 495     


Gly Ala Leu Ile Leu Ala Ser Trp Pro Gln Gln Ser Pro Val Thr Asp 
            500                 505                 510         


Val Thr Ser Gly Lys Leu Phe Ser Asn Phe Asn Ile Ile Ser Gly Thr 
        515                 520                 525             


Ser Met Ser Cys Pro His Ala Ser Gly Val Ala Ala Leu Leu Lys Gly 
    530                 535                 540                 


Ala His Pro Glu Trp Ser Pro Ala Ala Ile Arg Ser Ala Met Met Thr 
545                 550                 555                 560 


Thr Ser Ser Ala Leu Asp Asn Thr Gln Ser Pro Ile Arg Asp Ile Gly 
                565                 570                 575     


Asn Val Glu Leu Arg Asn Ala Ala Ala Thr Pro Leu Ala Met Gly Ala 
            580                 585                 590         


Gly His Ile Asp Pro Asn Lys Ala Leu Asp Pro Gly Leu Ile Tyr Asp 
        595                 600                 605             


Ala Thr Pro Gln Asp Tyr Val Asn Leu Leu Cys Ala Leu Asn Phe Thr 
    610                 615                 620                 


Ser Lys Gln Ile Lys Ile Ile Thr Arg Ser Ser Ser Tyr Thr Cys Ser 
625                 630                 635                 640 


Asn Pro Ser Leu Asp Leu Asn Tyr Pro Ser Phe Ile Gly Phe Phe Asn 
                645                 650                 655     


Gly Asn Ser Arg Glu Ser Asp Pro Lys Arg Ile Gln Glu Phe Lys Arg 
            660                 665                 670         


Thr Val Thr Asn Leu Gln Asp Gly Thr Ser Val Tyr Thr Ala Asn Leu 
        675                 680                 685             


Thr Pro Met Gly Lys Phe Lys Val Ser Val Val Pro Glu Lys Leu Val 
    690                 695                 700                 


Phe Lys Glu Lys Tyr Glu Lys Leu Ser Tyr Lys Leu Arg Ile Glu Gly 
705                 710                 715                 720 


Pro Ile Val Met Asp Asp Asn Val Val Tyr Gly Ser Leu Ser Trp Val 
                725                 730                 735     


Glu Thr Gly Gly Lys Tyr Val Val Arg Ser Pro Ile Val Ala Thr Ser 
            740                 745                 750         


Ile Lys Val Asp Pro Leu Thr Gly His Asn 
        755                 760         


<210>  17
<211>  2289
<212>  DNA
<213>  Nicotiana tabacum

<400>  17
atggcaaatc atattacctt gtgtatttgg ttgcttttct tctttatttc tataatttca       60

ctagcaaagt cagaaacata tatcattcat atggattttt cagccatgcc aaaagctttt      120

tctagccatc ataattggta cttgacaaca ctttcttctg tatcagacag cagtacaaat      180

tacaaagact tcttgtcctc aaaactagtc tattcttata ctaatgccat acatggtttt      240

agtgcaagtc tttctccttc tgaacttgaa gccataaaaa attctccagg ctatgtttct      300

tcaattaagg atatttcagt taaaattgac acaactcaca catcccaatt tcttggccta      360

aactctgagt ctggtgtatg gccaacgtcc gagtatggta aagatatcat aattggctta      420

gttgatactg gaatatggtc ggagagtaaa agctatagtg atgatgggat tagtgaagta      480

ccatcaagat ggaaaggaga atgtgaaagt ggtactgagt tcaattcctc tttgtgtaac      540

aagaaactca ttggcgctcg ttacttcaat aaaggcctac ttgccaacaa tccaaatctt      600

aacatttcaa tgaattctgc tagagatacc gatggacatg gaactcacac ttcttctaca      660

gctgcgggaa gttatgtcga gggtgcatct tattttggct atgccactgg cactgctata      720

ggcatagcac caaaggctca tgtggctatg tacaaggctc tatgggaaga aggtgtatac      780

ttgtctgatg ttcttgctgc aattgatcaa gcaattacag atggtgtgga tgtcttatcc      840

ttgtctttag gcatagacgc gattccacta cacgaagatc ctgtggcaat tgccgcattt      900

gctgcattgg agaaaggtat atttgtttcc acctctgcag gaaatgaagg gccttattat      960

gagactttgc acaatggaac accttgggtg ctaactgttg cagctggcac agttgaccgc     1020

gaatttattg gaacattaac tcttggaaat ggagtttcag tcactggctt atcgctatac     1080

cctgggaatt ctagttcaag cgaaagctcc attgtctatg tcgaatgcca agatgacaag     1140

gaactacaga aaaatgcaca taaatttgtt gtctgtctcg acaagaatga ttcggtcggt     1200

gagcatgtgt acaatgtaag aaattcaaaa gttgctgggg ctgtctttat aactaataca     1260

actgacttgg aattctacct ccaaagcgaa ttcccggctg tgttcttgaa cttacaagag     1320

ggtgataaag ttctagagta cattaagagc aactctgcac ctaaaggaaa acttgaattc     1380

caagtgacac atattggtgc taaacgagca ccagaagttg ctacctatag ctcaagagga     1440

ccgtcaccga gttgtccaag tatcctcaag cctgatctca tggctcctgg tgccttaata     1500

cttgcttcat ggccacagca atcaccagtt actgatgtta cctcaggaaa gctttttagt     1560

aacttcaata ttatatctgg tacatcaatg tcatgtccac atgcttctgg tgtagcagca     1620

cttctaaaag gcgcacaccc tgaatggagc cccgcagcca tccgatctgc catgatgacc     1680

acttccagtg cgttggacaa cacacagagc cccatccgag acataggtaa tgttgaactc     1740

aggaatgctg ctgctactcc tctagccatg ggagctggcc atatcgatcc aaacaaggca     1800

ttagatcctg gacttatcta tgatgcgaca ccacaagatt atgtcaatct tctctgtgct     1860

ctgaacttca catccaaaca aataaaaatc atcacaagat cctcatctta tacttgctcc     1920

aacccatcat tggacttaaa ctatccatcc ttcattggct ttttcaatgg gaacagcaga     1980

gagtcggatc ctaaaaggat tcaagaattc aaaagaacag tgacaaactt acaagatggt     2040

acatcagtat atacagcaaa tctcactcca atgggtaaat ttaaagttag tgttgtacct     2100

gaaaagttgg ttttcaaaga gaagtatgaa aagctgagct acaagcttag aatagaaggt     2160

ccaatagtta tggatgataa tgtggtttat ggttctttga gctgggtaga aactggaggt     2220

aaatatgtgg ttagaagtcc aattgttgcc acaagcataa aagtggatcc tttgacagga     2280

cacaactga                                                             2289


<210>  18
<211>  759
<212>  PRT
<213>  Nicotiana tabacum

<400>  18

Met Ala Ser His Ile Thr Leu Cys Ile Trp Leu Leu Phe Phe Phe Ile 
1               5                   10                  15      


Ser Ile Ile Ser Leu Ala Lys Pro Glu Thr Tyr Ile Ile His Met Asp 
            20                  25                  30          


Leu Ser Ala Met Pro Lys Ala Phe Ala Ser His His Asn Trp Tyr Leu 
        35                  40                  45              


Thr Thr Leu Ala Ser Leu Ser Asp Ser Ser Thr Asn His Lys Glu Phe 
    50                  55                  60                  


Leu Ser Ser Lys Leu Val Tyr Ala Tyr Thr Asn Ala Ile Asn Gly Phe 
65                  70                  75                  80  


Ser Ala Ser Leu Ser Pro Ser Glu Phe Glu Ala Ile Lys Asn Ser Pro 
                85                  90                  95      


Gly Tyr Val Ser Ser Ile Lys Asp Met Ser Val Lys Ile Asp Thr Thr 
            100                 105                 110         


His Thr Ser Gln Phe Leu Gly Leu Asn Ser Glu Ser Gly Val Trp Pro 
        115                 120                 125             


Thr Ser Asp Tyr Gly Lys Asp Ile Ile Ile Gly Leu Val Asp Thr Gly 
    130                 135                 140                 


Ile Trp Pro Glu Ser Lys Ser Tyr Ser Asp Tyr Gly Ile Ser Glu Val 
145                 150                 155                 160 


Pro Ser Arg Trp Lys Gly Glu Cys Glu Ser Gly Ile Glu Phe Asn Ser 
                165                 170                 175     


Ser Leu Cys Asn Lys Lys Ile Ile Gly Ala Arg Tyr Phe Asn Lys Gly 
            180                 185                 190         


Leu Leu Ala Asn Asn Pro Asn Leu Asn Ile Ser Met Asn Ser Ala Arg 
        195                 200                 205             


Asp Thr Asp Gly His Gly Thr His Thr Ser Ser Thr Ala Ala Gly Ser 
    210                 215                 220                 


Tyr Val Glu Gly Ala Ser Tyr Phe Gly Tyr Ala Thr Gly Thr Ala Ile 
225                 230                 235                 240 


Gly Ile Ala Pro Lys Ala His Val Ala Met Tyr Lys Ala Leu Trp Glu 
                245                 250                 255     


Glu Gly Val Tyr Leu Ser Asp Val Leu Ala Ala Ile Asp Gln Ala Ile 
            260                 265                 270         


Thr Asp Gly Val Asp Val Leu Ser Leu Ser Leu Gly Ile Asp Ala Ile 
        275                 280                 285             


Pro Leu His Glu Asp Pro Val Ala Ile Ala Ala Phe Ala Ala Leu Glu 
    290                 295                 300                 


Lys Gly Ile Phe Val Ser Thr Ser Ala Gly Asn Glu Gly Pro Tyr Tyr 
305                 310                 315                 320 


Glu Thr Leu His Asn Gly Thr Pro Trp Val Leu Thr Val Ala Ala Gly 
                325                 330                 335     


Thr Val Asp Arg Glu Phe Ile Gly Ala Leu Thr Leu Gly Asn Gly Val 
            340                 345                 350         


Ser Val Thr Gly Leu Ser Leu Tyr Pro Gly Asn Ser Ser Ser Ser Glu 
        355                 360                 365             


Ser Ser Ile Val Tyr Val Glu Cys Gln Asp Asp Lys Glu Leu Gln Lys 
    370                 375                 380                 


Ser Ala His Asn Ile Val Val Cys Leu Asp Lys Asn Asp Ser Val Ser 
385                 390                 395                 400 


Glu His Val Tyr Asn Val Arg Asn Ser Lys Val Ala Gly Ala Val Phe 
                405                 410                 415     


Ile Thr Asn Ile Thr Asp Leu Glu Phe Tyr Leu Gln Ser Glu Phe Pro 
            420                 425                 430         


Ala Val Phe Leu Asn Leu Gln Glu Gly Asp Lys Val Leu Glu Tyr Ile 
        435                 440                 445             


Lys Ser Asn Ser Ala Pro Lys Gly Lys Leu Glu Phe Arg Val Thr His 
    450                 455                 460                 


Ile Gly Ala Lys Pro Ala Pro Lys Val Ala Thr Tyr Ser Ser Arg Gly 
465                 470                 475                 480 


Pro Ser Pro Ser Cys Pro Ser Ile Leu Lys Pro Asp Leu Met Ala Pro 
                485                 490                 495     


Gly Ala Leu Ile Leu Ala Ser Trp Pro Gln Gln Ser Pro Val Thr Asp 
            500                 505                 510         


Val Thr Ser Gly Lys Leu Phe Ser Asn Phe Asn Ile Ile Ser Gly Thr 
        515                 520                 525             


Ser Met Ser Cys Pro His Ala Ser Gly Val Ala Ala Leu Leu Lys Ala 
    530                 535                 540                 


Ala His Pro Glu Trp Ser Pro Ala Ala Ile Arg Ser Ala Met Met Thr 
545                 550                 555                 560 


Thr Ser Asn Ala Met Asp Asn Thr Gln Ser Pro Ile Arg Asp Ile Gly 
                565                 570                 575     


Ser Lys Asn Ala Ala Ala Thr Pro Leu Ala Met Gly Ala Gly His Ile 
            580                 585                 590         


Asp Pro Asn Lys Ala Leu Asp Pro Gly Leu Ile Tyr Asp Ala Thr Pro 
        595                 600                 605             


Gln Asp Tyr Val Asn Leu Leu Cys Ala Leu Asn Phe Thr Ser Lys Gln 
    610                 615                 620                 


Ile Lys Thr Ile Thr Arg Ser Ser Ser Tyr Thr Cys Ser Asn Pro Ser 
625                 630                 635                 640 


Leu Asp Leu Asn Tyr Pro Ser Phe Ile Gly Phe Phe Asn Gly Asn Ser 
                645                 650                 655     


Ser Glu Ser Asp Pro Arg Arg Ile Gln Glu Phe Gln Arg Thr Val Thr 
            660                 665                 670         


Asn Ile Gly Asp Gly Met Ser Val Tyr Thr Ala Lys Leu Thr Thr Met 
        675                 680                 685             


Gly Lys Phe Lys Val Asn Leu Val Pro Glu Lys Leu Val Phe Lys Glu 
    690                 695                 700                 


Lys Tyr Glu Lys Leu Ser Tyr Lys Leu Arg Ile Glu Gly Pro Leu Val 
705                 710                 715                 720 


Met Asp Asp Ile Val Val Tyr Gly Ser Leu Ser Trp Val Glu Thr Glu 
                725                 730                 735     


Gly Lys Tyr Val Val Arg Ser Pro Ile Val Ala Thr Ser Ile Lys Val 
            740                 745                 750         


Asp Pro Leu Thr Gly His Asn 
        755                 


<210>  19
<211>  2280
<212>  DNA
<213>  Nicotiana tabacum

<400>  19
atggcaagtc atattacctt gtgtatttgg ttgcttttct tctttatttc tataatttca       60

ctagcaaagc cagaaacata tatcattcat atggatttgt cagccatgcc aaaagctttt      120

gctagccatc ataattggta cttgacaaca cttgcttctt tatcagacag tagtacaaat      180

cacaaagaat tcttgtcctc aaaactagtc tatgcttata ctaatgccat caatggtttt      240

agtgcaagtc tttctccttc tgaatttgaa gccataaaaa attctccagg ttatgtttct      300

tcaattaagg atatgtcagt taaaattgac acaactcaca catcccaatt ccttggccta      360

aactctgagt ctggtgtatg gccaacgtcc gactatggta aagatatcat aattggctta      420

gttgatactg gaatatggcc agagagtaaa agctatagtg attatgggat tagtgaagta      480

ccatcaagat ggaaaggaga atgtgaaagt ggcattgagt tcaattcctc tttgtgtaac      540

aagaaaatca ttggcgctcg ttacttcaat aaaggcctac ttgccaacaa tccaaatctt      600

aacatttcaa tgaattctgc tagagataca gatggacatg gaactcacac ttcttccaca      660

gctgcgggaa gttatgtcga gggtgcatct tattttggct atgccaccgg cactgctatt      720

ggcatagcac caaaggctca tgtggctatg tacaaggctc tatgggaaga aggtgtatac      780

ttgtctgatg ttcttgctgc aattgatcaa gcaattacag atggtgtaga tgttttatcc      840

ttgtcattag gcatagacgc gattccacta cacgaagatc ctgtggcaat tgccgcattt      900

gctgcattgg agaaaggtat atttgtttcc acctctgcag gaaatgaagg gccttattat      960

gagactttgc acaatggaac accttgggtg ctaactgttg cagctggcac agttgaccgc     1020

gaatttattg gcgcattaac tcttggaaat ggagtttcag tcactggctt atcgctctac     1080

cctgggaatt ctagttcaag tgaaagctcc attgtctatg ttgaatgcca agatgacaag     1140

gaactgcaaa aaagtgcaca caatattgtt gtctgccttg acaagaatga ttcggtcagt     1200

gagcatgtgt acaatgtgag aaattcaaaa gttgctgggg ctgtcttcat aactaatata     1260

actgatttgg aattctacct ccaaagcgaa ttcccggctg tgttcttgaa cttacaagag     1320

ggtgataaag ttctagagta cattaagagc aactctgcac ctaaaggaaa acttgaattc     1380

cgagtgacac atattggtgc taaaccagca ccaaaagttg ctacctatag ctcaagagga     1440

ccgtcaccga gctgtccaag tatcctcaag cctgatctca tggctcctgg tgccttaata     1500

ctagcttcat ggccacaaca atcaccagtg actgatgtta cctcaggaaa actttttagt     1560

aacttcaata ttatatctgg tacatcaatg tcatgtccac atgcttctgg tgtagcagca     1620

cttctaaaag ccgcacaccc tgaatggagc cctgcagcca tccgatctgc catgatgacc     1680

acttccaatg cgatggacaa cacacaaagt cccatccgag acataggtag taagaatgct     1740

gctgctactc ctctagccat gggagctggc catatcgatc caaacaaggc actagatcct     1800

ggacttatct atgatgcgac accacaagat tatgtcaatc ttctctgtgc tctgaacttc     1860

acatccaaac aaataaaaac catcacaaga tcctcatctt atacttgctc caacccatca     1920

ttggacttaa actatccatc tttcattgga tttttcaatg ggaacagcag cgagtcggat     1980

cctagaagga tacaagaatt ccagaggacc gtgactaata ttggagatgg tatgtcagta     2040

tacacagcaa aattgaccac aatgggtaaa tttaaagtta atcttgtacc tgaaaagttg     2100

gttttcaaag agaagtatga aaagttgagc tacaagctaa gaatagaagg tccattagtt     2160

atggatgata ttgtggttta tggttctttg agctgggtag aaactgaagg taaatatgtg     2220

gttagaagtc caattgttgc cacaagcata aaagtagatc ctttgacagg acacaactga     2280


<210>  20
<211>  751
<212>  PRT
<213>  Solanum lycopersicum

<400>  20

Met Ala Asn Tyr Ile Ala Leu Cys Ile Trp Leu Leu Ser Ile Ile Gln 
1               5                   10                  15      


Leu Ala Lys Ser Glu Thr Tyr Ile Ile His Met Asp Leu Ser Ala Met 
            20                  25                  30          


Pro Lys Ala Phe Ser Ser His Tyr Asn Trp Tyr Leu Thr Thr Leu Phe 
        35                  40                  45              


Ser Val Ser Asp Ser Lys Asp Leu Leu Ser Ser Lys Leu Val Tyr Thr 
    50                  55                  60                  


Tyr Thr Asn Ala Ile Asn Gly Phe Ser Ala Ser Leu Ser Pro Ser Glu 
65                  70                  75                  80  


Ile Glu Ala Ile Lys Asn Ser Pro Gly Tyr Val Ser Ser Ile Lys Asp 
                85                  90                  95      


Met Ser Val Lys Val Asp Thr Thr His Thr Ser Gln Phe Leu Gly Leu 
            100                 105                 110         


Asn Ser Glu Ser Gly Val Trp Pro Lys Ser Asp Tyr Gly Lys Asp Val 
        115                 120                 125             


Ile Val Gly Leu Val Asp Thr Gly Ile Trp Pro Glu Ser Arg Ser Tyr 
    130                 135                 140                 


Ser Asp Asp Gly Met Asn Glu Val Pro Ser Arg Trp Lys Gly Glu Cys 
145                 150                 155                 160 


Glu Ser Gly Thr Gln Phe Asn Thr Ser Leu Cys Asn Lys Lys Leu Ile 
                165                 170                 175     


Gly Ala Arg Tyr Phe Asn Lys Gly Leu Leu Ala Asn Asn Pro Asn Leu 
            180                 185                 190         


Thr Ile Ser Met Asp Ser Ala Arg Asp Thr Asp Gly His Gly Thr His 
        195                 200                 205             


Thr Ser Ser Thr Ala Ala Gly Ser Arg Val Glu Gly Ala Ser Phe Phe 
    210                 215                 220                 


Gly Tyr Ala Ala Gly Thr Ala Thr Gly Val Ala Pro Lys Ala His Val 
225                 230                 235                 240 


Ala Met Tyr Lys Ala Leu Trp Glu Glu Gly Val Phe Leu Ser Asp Ile 
                245                 250                 255     


Leu Ala Ala Ile Asp Gln Ala Ile Ala Asp Gly Val Asp Val Leu Ser 
            260                 265                 270         


Leu Ser Leu Gly Ile Asp Ala Leu Pro Leu Tyr Glu Asp Pro Val Ala 
        275                 280                 285             


Ile Ala Ala Phe Ala Ala Leu Glu Lys Gly Ile Phe Val Ser Thr Ser 
    290                 295                 300                 


Ala Gly Asn Glu Gly Pro Phe Leu Glu Thr Leu His Asn Gly Thr Pro 
305                 310                 315                 320 


Trp Val Leu Thr Val Ala Ala Gly Thr Val Asp Arg Glu Phe Ile Gly 
                325                 330                 335     


Thr Val Thr Leu Gly Asn Gly Val Ser Val Thr Gly Leu Ser Leu Tyr 
            340                 345                 350         


Pro Gly Asn Ser Ser Ser Ser Glu Ser Ser Ile Ser Phe Val Asp Cys 
        355                 360                 365             


Gln Asp Asp Lys Glu Leu Gln Lys Asn Ala His Arg Ile Val Val Cys 
    370                 375                 380                 


Ile Asp Asn Asn Asp Ser Val Ser Glu Asp Val Tyr Asn Val Arg Asn 
385                 390                 395                 400 


Ser Lys Val Ser Gly Ala Val Phe Ile Thr Asn Ser Thr Asp Leu Glu 
                405                 410                 415     


Phe Tyr Leu Gln Ser Glu Phe Pro Ala Val Phe Leu Asn Ile Gln Glu 
            420                 425                 430         


Gly Asp Lys Val Leu Glu Tyr Val Arg Ser Asp Ser Ala Pro Asn Ala 
        435                 440                 445             


Lys Leu Glu Phe Gln Val Thr Arg Ile Gly Ala Lys Pro Ala Pro Lys 
    450                 455                 460                 


Val Ala Ser Tyr Ser Ser Arg Gly Pro Ser Pro Ser Cys Pro Thr Ile 
465                 470                 475                 480 


Leu Lys Pro Asp Leu Met Gly Pro Gly Ala Leu Ile Leu Ala Ser Trp 
                485                 490                 495     


Pro Gln Gln Thr Pro Val Thr Glu Val Thr Ser Gly Lys Leu Tyr Ser 
            500                 505                 510         


Asn Phe Asn Ile Ile Ser Gly Thr Ser Met Ser Cys Pro His Ala Ser 
        515                 520                 525             


Gly Val Ala Ala Leu Leu Lys Ser Ala His Pro Glu Trp Ser Pro Ala 
    530                 535                 540                 


Ala Ile Arg Ser Ala Met Met Thr Thr Ala Tyr Val Leu Asp Asn Thr 
545                 550                 555                 560 


Gln Ser Pro Ile Gln Asp Val Gly Leu Lys Asn Gly Val Ala Thr Pro 
                565                 570                 575     


Leu Ala Met Gly Ala Gly His Ile Asp Pro Asn Lys Ala Leu Asp Pro 
            580                 585                 590         


Gly Leu Ile Tyr Asp Ala Thr Pro Gln Asp Tyr Val Asn His Leu Cys 
        595                 600                 605             


Gly Leu Asn Phe Thr Ser Lys Gln Ile Gln Thr Ile Thr Arg Ser Ser 
    610                 615                 620                 


Thr Tyr Thr Cys Ser Asn Pro Ser Leu Asp Leu Asn Tyr Pro Ser Phe 
625                 630                 635                 640 


Ile Gly Tyr Phe Asn Arg Asn Ser Ser Asp Ser Asp Pro Lys Arg Ile 
                645                 650                 655     


Gln Glu Phe Lys Arg Thr Val Thr Asn Leu Gln Asp Gly Thr Ser Val 
            660                 665                 670         


Tyr Thr Ala Lys Leu Thr Pro Met Gly Lys Phe Lys Val Ser Val Val 
        675                 680                 685             


Pro Asn Lys Leu Thr Phe Lys Glu Lys Tyr Glu Lys Gln Ser Tyr Lys 
    690                 695                 700                 


Leu Arg Ile Glu Gly Pro Ile Ile Met Asp Asp Ile Val Val Asp Gly 
705                 710                 715                 720 


Ser Leu Ser Trp Met Glu Thr Arg Gly Lys Tyr Ile Val Lys Ser Pro 
                725                 730                 735     


Ile Val Ala Thr Ser Ile Arg Val Asp Pro Leu Arg Gly His Asn 
            740                 745                 750     


<210>  21
<211>  2256
<212>  DNA
<213>  Solanum lycopersicum

<400>  21
atggcaaatt atattgcctt gtgtatttgg ttgctttcta taattcaatt ggcaaagtca       60

gaaacttata tcattcatat ggatttgtca gccatgccaa aagctttttc tagccattat      120

aattggtact tgactacact tttttcggtg tcagatagca aagacttgtt gtcctctaaa      180

ctagtttata cttatactaa tgccatcaat ggtttcagtg caagtctttc tccttctgag      240

atagaagcta ttaagaattc tccgggttat gtttcttcga ttaaggatat gtcggttaaa      300

gttgacacaa cccacacatc tcaattcctt ggccttaact ctgagtctgg tgtatggcca      360

aagtcggatt atggcaaaga tgttatagtt ggattagttg acactgggat atggccagag      420

agtagaagtt atagtgatga tgggatgaat gaagtaccat caagatggaa aggagaatgt      480

gaaagtggaa ctcagttcaa tacctctttg tgcaataaga aactcattgg cgctcgttac      540

ttcaataaag gcctacttgc taacaacccg aatcttacca tttcgatgga ttctgctcgt      600

gatacggatg gacatgggac tcacacttct tccacggctg ctggaagtcg tgtagagggt      660

gcatcttttt ttggatatgc tgctggaact gctacaggtg tagcaccaaa ggctcatgtg      720

gccatgtaca aggctctatg ggaagaaggt gtattcttgt ctgatattct tgcagcaatt      780

gatcaagcaa ttgcagatgg tgtagatgta ttgtccttgt cattaggcat tgatgcgctt      840

cctttatacg aagatcctgt tgcaattgcc gcatttgctg cactggagaa aggcatattt      900

gtttctacat ctgcaggaaa tgaagggcct tttttggaaa ctttgcacaa tggaacgcct      960

tgggtgctca ctgttgctgc tggcacagtt gaccgggagt ttattggcac agtaacactt     1020

ggaaatggag tttcggtcac tggattatcg ctctaccctg ggaactctag ttcaagtgaa     1080

agctccatta gcttcgttga ttgccaagat gataaggaac tgcagaaaaa tgcacacaga     1140

atagtggtct gcattgacaa taatgattca gttagcgagg acgtctacaa tgtaagaaat     1200

tcaaaagttt ctggtgcagt cttcataact aattcaactg acttggaatt ctatctccaa     1260

agtgaatttc ccgcggtgtt tttgaacatt caagagggtg ataaagttct tgagtacgtt     1320

aggagtgact ctgcacctaa cgcaaagctt gaattccaag tgacgcgtat tggtgctaaa     1380

ccagcaccaa aagttgctag ctatagctca agaggaccat caccaagctg tcctacaatt     1440

ctaaagcctg accttatggg tcctggtgca ttaatacttg cttcatggcc acaacaaaca     1500

ccagtaactg aagttacctc gggaaaactt tatagtaact tcaacattat atcaggcaca     1560

tcaatgtctt gtccacatgc ttctggtgta gcagcacttc taaaaagtgc acaccctgaa     1620

tggagccctg ctgctatccg atccgccatg atgaccacag cctatgtatt ggacaacaca     1680

caaagcccca tccaagacgt aggtctgaag aatggtgttg ctactcctct agctatggga     1740

gctggccata tcgatccaaa caaagcgttg gatcccggac tcatctatga tgcaacacca     1800

caagattatg ttaaccacct ctgtggtttg aacttcacat ccaaacaaat acaaaccatc     1860

acaagatcct caacttacac ttgctccaac ccatcattag acttgaacta tccatcattc     1920

attggctatt tcaaccggaa tagcagcgat tcggatccta aaaggattca agaattcaaa     1980

agaacagtga ctaacttaca agatggtaca tcagtataca cagcaaagct cactccaatg     2040

ggtaaattta aagttagtgt tgtacctaat aagttgactt tcaaagaaaa gtatgaaaaa     2100

caaagctata agctaagaat agaaggtcca ataattatgg atgatattgt ggttgatggt     2160

tcattgagct ggatggaaac tagaggaaaa tacatagtta aaagtccaat tgttgcaaca     2220

agtataagag tggatccttt gagaggacat aactga                               2256


<210>  22
<211>  751
<212>  PRT
<213>  Solanum tuberosum

<400>  22

Met Ala Asn His Ile Ala Leu Cys Ile Trp Leu Leu Ser Ile Ile Gln 
1               5                   10                  15      


Leu Ala Lys Ser Glu Thr Tyr Ile Ile His Met Asp Leu Ser Ala Met 
            20                  25                  30          


Pro Lys Ala Phe Ser Ser His His Asn Trp Tyr Leu Thr Thr Leu Ser 
        35                  40                  45              


Ser Val Ser Asp Ser Lys Asp Leu Leu Ser Ser Lys Leu Val Tyr Thr 
    50                  55                  60                  


Tyr Thr Asn Ala Ile Asn Gly Phe Ser Ala Ser Leu Ser Pro Ser Glu 
65                  70                  75                  80  


Ile Glu Ala Ile Lys Asn Ser Pro Gly Tyr Val Ser Ser Ile Lys Asp 
                85                  90                  95      


Met Ser Val Lys Val Asp Thr Thr His Thr Ser Gln Phe Leu Gly Leu 
            100                 105                 110         


Asn Ser Glu Ser Gly Val Trp Pro Lys Ser Asp Tyr Gly Lys Asp Val 
        115                 120                 125             


Ile Val Gly Leu Val Asp Thr Gly Ile Trp Pro Glu Ser Arg Ser Tyr 
    130                 135                 140                 


Ser Asp Asp Gly Met Asn Glu Val Pro Ser Arg Trp Lys Gly Glu Cys 
145                 150                 155                 160 


Glu Ser Gly Thr Gln Phe Asn Ser Ser Leu Cys Asn Lys Lys Leu Ile 
                165                 170                 175     


Gly Ala Arg Tyr Phe Asn Lys Gly Leu Leu Ala Asn Asn Pro Asn Leu 
            180                 185                 190         


Thr Ile Ser Met Asp Ser Ser Arg Asp Thr Asp Gly His Gly Thr His 
        195                 200                 205             


Thr Ser Ser Thr Ala Ala Gly Ser Arg Val Glu Gly Ala Ser Phe Phe 
    210                 215                 220                 


Gly Tyr Ala Ala Gly Thr Ala Thr Gly Val Ala Pro Lys Ala His Val 
225                 230                 235                 240 


Ala Met Tyr Lys Ala Leu Trp Glu Glu Gly Val Phe Leu Ser Asp Ile 
                245                 250                 255     


Leu Ala Ala Ile Asp Gln Ala Ile Glu Asp Gly Val Asp Val Leu Ser 
            260                 265                 270         


Leu Ser Leu Gly Ile Asp Ala Leu Pro Leu Tyr Glu Asp Pro Val Ala 
        275                 280                 285             


Ile Ala Ala Phe Ala Ala Leu Glu Lys Gly Ile Phe Val Ser Thr Ser 
    290                 295                 300                 


Ala Gly Asn Glu Gly Pro Phe Leu Glu Thr Leu His Asn Gly Thr Pro 
305                 310                 315                 320 


Trp Val Leu Thr Val Ala Ala Gly Thr Val Asp Arg Glu Phe Ile Gly 
                325                 330                 335     


Thr Leu Thr Leu Gly Asn Gly Val Ser Val Thr Gly Leu Ser Leu Tyr 
            340                 345                 350         


Pro Gly Asn Ser Ser Ser Ser Glu Arg Ser Ile Ser Tyr Val Asp Cys 
        355                 360                 365             


Gln Asp Asp Lys Glu Leu Gln Lys Asn Ala His Lys Ile Val Val Cys 
    370                 375                 380                 


Ile Asp Lys Ser Asp Ser Val Ser Glu Asp Val Tyr Asn Val Arg Asn 
385                 390                 395                 400 


Ser Lys Val Ser Gly Ala Val Phe Ile Thr Asn Ser Thr Asp Leu Glu 
                405                 410                 415     


Phe Tyr Leu Gln Ser Glu Phe Pro Ala Val Phe Leu Asn Ile Gln Glu 
            420                 425                 430         


Gly Asp Lys Val Leu Glu Tyr Val Arg Ser Glu Ala Ala Pro Asn Ala 
        435                 440                 445             


Lys Leu Glu Phe Gln Val Thr Arg Ile Gly Ala Lys Pro Ala Pro Lys 
    450                 455                 460                 


Val Ala Ser Tyr Ser Ser Arg Gly Pro Ser Pro Ser Cys Pro Ile Ile 
465                 470                 475                 480 


Leu Lys Pro Asp Leu Met Gly Pro Gly Ala Leu Ile Leu Ala Ser Trp 
                485                 490                 495     


Pro Gln Gln Thr Pro Val Thr Glu Val Thr Ser Gly Lys Leu Tyr Ser 
            500                 505                 510         


Asn Phe Asn Ile Ile Ser Gly Thr Ser Met Ser Cys Pro His Ala Ser 
        515                 520                 525             


Gly Val Ala Ala Leu Leu Lys Ser Ala His Pro Glu Trp Ser Pro Ala 
    530                 535                 540                 


Ala Ile Arg Ser Ala Met Met Thr Thr Ala Tyr Val Leu Asp Asn Thr 
545                 550                 555                 560 


Gln Ser Pro Ile Gln Asp Ile Gly Leu Lys Asn Gly Val Ala Thr Pro 
                565                 570                 575     


Leu Ala Met Gly Ala Gly His Ile Asp Pro Asn Lys Ala Leu Asp Pro 
            580                 585                 590         


Gly Leu Ile Tyr Asp Ala Thr Pro Gln Asp Tyr Val Asn Leu Leu Cys 
        595                 600                 605             


Ala Leu Asn Phe Thr Ser Lys Gln Ile Gln Thr Ile Thr Arg Ser Ser 
    610                 615                 620                 


Thr Tyr Thr Cys Ser Asn Pro Ser Leu Asp Leu Asn Tyr Pro Ser Phe 
625                 630                 635                 640 


Ile Gly Tyr Phe Asn Arg Asn Ser Ser Asp Ser Asp Pro Lys Arg Ile 
                645                 650                 655     


Gln Glu Phe Ile Arg Thr Val Thr Asn Leu Gln Asp Gly Thr Ser Val 
            660                 665                 670         


Tyr Thr Ala Lys Ile Thr Pro Met Gly Lys Phe Lys Val Ser Val Val 
        675                 680                 685             


Pro Asn Lys Leu Ile Phe Lys Glu Lys Tyr Glu Lys Gln Ser Tyr Lys 
    690                 695                 700                 


Leu Arg Ile Glu Gly Pro Ile Ile Met Asp Asp Ile Val Val Asp Gly 
705                 710                 715                 720 


Ser Leu Ser Trp Met Glu Thr Arg Gly Lys Tyr Ile Val Lys Ser Pro 
                725                 730                 735     


Ile Val Ala Thr Ser Ile Arg Val Asp Pro Leu Arg Gly His Asn 
            740                 745                 750     


<210>  23
<211>  2256
<212>  DNA
<213>  Solanum tuberosum

<400>  23
atggcaaatc atattgcctt gtgtatttgg ttgctttcta taattcaatt ggcaaagtca       60

gaaacttata tcattcatat ggatttgtca gccatgccaa aagctttttc tagccatcat      120

aattggtact tgactacact ttcttctgta tcagatagca aagacttgtt gtcctctaaa      180

ctagtttata cttatactaa tgccatcaat ggtttcagtg caagtctttc tccttctgag      240

atagaagcta ttaagaattc tcccggctat gtttcttcga ttaaggatat gtcggttaaa      300

gttgacacaa ctcacacatc tcaattcctt ggccttaact ctgagtctgg tgtatggcca      360

aagtctgatt atggcaaaga tgtcatagtt ggattagttg acactgggat atggccagag      420

agtagaagtt atagtgatga tgggatgaat gaagtaccat caagatggaa aggagaatgt      480

gaaagtggaa ctcagttcaa ttcctctttg tgcaataaga aactcattgg cgctcgttac      540

ttcaataaag gcctacttgc taacaacccg aatcttacca tttcgatgga ttcttctcgt      600

gatacggatg gacatgggac tcatacttct tccacggctg ctggaagtcg tgtagagggt      660

gcatcttttt ttggctatgc cgctggaaca gctacaggtg tagcaccaaa ggctcatgtg      720

gccatgtaca aggctctatg ggaagaaggt gtattcttgt ctgatattct tgcagcaatt      780

gatcaagcaa ttgaagatgg tgtagatgta ttgtcgttgt cattaggcat tgacgcgctt      840

ccattatacg aagatcctgt tgcaattgct gcatttgctg cactggagaa aggcatattt      900

gtttctacat ctgcaggaaa tgaagggcca tttttggaaa ctttgcacaa tggaacacct      960

tgggtgctca ctgttgctgc tggcacggtt gaccgtgagt ttattggcac actaacactt     1020

ggaaatggag tttcggtcac tggattatcg ctctaccctg ggaattctag ttcaagtgaa     1080

cgctccatta gctatgttga ttgccaagat gataaggaac tgcagaaaaa tgcacacaaa     1140

atagtggtct gcattgacaa gagtgattca gttagcgaag acgtctacaa tgtaagaaat     1200

tcaaaagttt ctggtgcagt cttcataact aattcaactg acttggaatt ctacctccaa     1260

agtgaatttc ctgcagtgtt tttgaacatt caagagggtg ataaagttct tgagtatgtt     1320

aggagtgagg ctgcacctaa cgcaaagctt gaattccaag tgacgcgtat tggtgctaaa     1380

ccagcaccaa aagttgctag ctatagctca agaggaccat caccaagttg tcctataatt     1440

ctcaagcctg acctcatggg tcctggtgcc ttaatacttg cttcatggcc acaacaaaca     1500

ccagtaactg aagttacctc aggaaaactt tatagtaact tcaacattat atcaggcaca     1560

tcaatgtctt gtccacatgc ttctggtgta gcagcacttc taaaaagtgc acaccctgaa     1620

tggagccctg ctgctatccg atccgccatg atgaccacag cctatgtatt ggacaacaca     1680

caaagcccca tccaagacat aggtttgaag aatggtgttg ctactcctct agctatggga     1740

gctggccata tcgatccaaa caaggcgttg gatcccggac tcatctatga tgcaacacca     1800

caagattatg ttaatctcct ttgtgctttg aacttcacat ccaaacaaat acaaaccatc     1860

acaagatcct caacttacac ttgctccaac ccatcattag acttgaacta tccatctttc     1920

attggctatt tcaaccggaa cagcagcgat tcagatccta aaaggattca agaattcata     1980

agaacagtga caaacttaca agatggtaca tcagtataca cagcaaagat cactccaatg     2040

ggtaaattta aagttagtgt tgtacctaat aagttgattt tcaaagaaaa gtatgaaaag     2100

caaagctaca agctaagaat agaaggtcca ataattatgg atgatattgt ggttgatggt     2160

tccttgagtt ggatggaaac tagaggaaaa tacatagtca aaagtccaat tgttgcaaca     2220

agtataagag tggatccttt gagaggacat aactga                               2256


<210>  24
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody construct 2G12HC

<400>  24

Met Ala Asn Lys His Leu Ser Leu Ser Leu Phe Leu Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ala Ser Leu Ala Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Ala Gly Gly Ser Leu Ile Leu Ser Cys Gly Val 
        35                  40                  45              


Ser Asn Phe Arg Ile Ser Ala His Thr Met Asn Trp Val Arg Arg Val 
    50                  55                  60                  


Pro Gly Gly Gly Leu Glu Trp Val Ala Ser Ile Ser Thr Ser Ser Thr 
65                  70                  75                  80  


Tyr Arg Asp Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg 
                85                  90                  95      


Asp Asp Leu Glu Asp Phe Val Tyr Leu Gln Met His Lys Met Arg Val 
            100                 105                 110         


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Lys Gly Ser Asp Arg Leu 
        115                 120                 125             


Ser Asp Asn Asp Pro Phe Asp Ala Trp Gly Pro Gly Thr Val Val Thr 
    130                 135                 140                 


Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  25
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody construct 2G12HC

<400>  25
atggcgaaca aacacttgtc cctctccctc ttcctcgtcc tccttggcct gtcggccagc       60

ttggcctcag gtgaggtgca gctggtggag tctgggggag gcctggtcaa ggcgggagga      120

tccctcatac tctcctgtgg agtctctaat tttagaatct ctgcccatac catgaattgg      180

gtccgccggg ttccaggggg ggggctggag tgggtcgctt ccattagtac gagttccact      240

tatagagact atgcagacgc tgtgaagggc cgattcaccg tttccagaga cgacctcgaa      300

gactttgtgt atttgcaaat gcacaaaatg agagtcgaag acacggctat ttattactgc      360

gccagaaagg gatctgacag actaagcgac aacgatcctt ttgatgcctg ggggccagga      420

acagtggtca ccgtctctcc cgcctccacc aagggcccat cggtcttccc cctggcaccc      480

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      540

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      600

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      660

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      720

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      780

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cttcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga           1434


<210>  26
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody construct 2G12HC (comprising an I19R mutation)

<400>  26

Met Ala Asn Lys His Leu Ser Leu Ser Leu Phe Leu Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ala Ser Leu Ala Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Val 
        35                  40                  45              


Ser Asn Phe Arg Ile Ser Ala His Thr Met Asn Trp Val Arg Arg Val 
    50                  55                  60                  


Pro Gly Gly Gly Leu Glu Trp Val Ala Ser Ile Ser Thr Ser Ser Thr 
65                  70                  75                  80  


Tyr Arg Asp Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg 
                85                  90                  95      


Asp Asp Leu Glu Asp Phe Val Tyr Leu Gln Met His Lys Met Arg Val 
            100                 105                 110         


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Lys Gly Ser Asp Arg Leu 
        115                 120                 125             


Ser Asp Asn Asp Pro Phe Asp Ala Trp Gly Pro Gly Thr Val Val Thr 
    130                 135                 140                 


Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  27
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody construct 2G12HC comprising an I19R mutation)

<400>  27
atggcgaaca aacacttgtc cctctccctc ttcctcgtcc tccttggcct gtcggccagc       60

ttggcctcag gtgaggtgca gctggtggag tctgggggag gcctggtcaa ggcgggagga      120

tccctcagac tctcctgtgg agtctctaat tttagaatct ctgcccatac catgaattgg      180

gtccgccggg ttccaggggg ggggctggag tgggtcgctt ccattagtac gagttccact      240

tatagagact atgcagacgc tgtgaagggc cgattcaccg tttccagaga cgacctcgaa      300

gactttgtgt atttgcaaat gcacaaaatg agagtcgaag acacggctat ttattactgc      360

gccagaaagg gatctgacag actaagcgac aacgatcctt ttgatgcctg ggggccagga      420

acagtggtca ccgtctctcc cgcctccacc aagggcccat cggtcttccc cctggcaccc      480

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      540

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      600

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      660

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      720

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      780

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cttcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga           1434


<210>  28
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody construct 2G12LC

<400>  28

Met Ala Asn Lys His Leu Ser Leu Ser Leu Phe Leu Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ala Ser Leu Ala Ser Gly Asp Val Val Met Thr Gln Ser Pro 
            20                  25                  30          


Ser Thr Leu Ser Ala Ser Val Gly Asp Thr Ile Thr Ile Thr Cys Arg 
        35                  40                  45              


Ala Ser Gln Ser Ile Glu Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Lys Thr 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Gln Phe Asp Asp Phe Ala Thr Tyr His Cys 
            100                 105                 110         


Gln His Tyr Ala Gly Tyr Ser Ala Thr Phe Gly Gln Gly Thr Arg Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  29
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody construct 2g12lc

<400>  29
atggcgaaca aacacttgtc cctctccctc ttcctcgtcc tccttggcct gtcggccagc       60

ttggcctcag gtgatgttgt gatgactcag tctccttcca ccctgtctgc atctgtcgga      120

gacacaatca ccatcacttg ccgggccagt cagagtattg aaacctggtt ggcctggtat      180

cagcagaagc cagggaaagc cccaaaactc ctaatctaca aggcgtctac tttaaaaact      240

ggagtcccgt caagattcag cggcagtgga tctggaacag agttcactct taccatcagt      300

ggcctgcagt tcgatgactt tgcaacttat cactgtcagc actatgctgg ttattcagcg      360

acgttcggcc aggggaccag ggtggagatc aaacgaactg tggctgcacc atctgtcttc      420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttag         717


<210>  30
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody construct 2F5 (heavy chain)

<400>  30

Arg Ile Thr Leu Lys Glu Ser Gly Pro Pro Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Asp Phe 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Ile Ile Tyr Ser Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Asn Thr Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Val Met Thr Arg Val Ser Pro Val Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala His Arg Arg Gly Pro Thr Thr Leu Phe Gly Val Pro Ile Ala 
            100                 105                 110         


Arg Gly Pro Val Asn Ala Met Asp Val Trp Gly Gln Gly Ile Thr Val 
        115                 120                 125             


Thr Ile Ser Ser Thr Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  31
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody construct I19R 2G12 (heavy chain)

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr 
65                  70                  75                  80  


Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala 
            100                 105                 110         


Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  32
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody construct PG9 (heavy chain)

<400>  32

Gln Arg Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Ser Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Gln Gly 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Phe Ile Lys Tyr Asp Gly Ser Glu Lys Tyr His Ala Asp Ser Val Trp 
    50                  55                  60                  


Gly Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Thr Tyr Phe Cys Val 
                85                  90                  95      


Arg Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn Tyr Tyr Asp 
            100                 105                 110         


Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val Trp Gly Lys 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease inhibitor

<400>  33

Met Met Lys Lys Asp Gln Ile Leu Ser Ser Ile Leu Leu Phe Phe Phe 
1               5                   10                  15      


Leu Phe Thr Ala Phe Ile Thr Thr Met Ala Asp Ser Gln Ala Ser Ser 
            20                  25                  30          


Gln Pro Ser Asn Glu Ser Lys Val His Ile Val Tyr Thr Glu Gln Pro 
        35                  40                  45              


Lys Asp Gln Glu Pro Glu Glu Tyr His Ile Lys Thr Leu Thr Ser Val 
    50                  55                  60                  


Leu Gly Ser Glu Glu Ala Ala Lys Glu Ala Leu Leu Tyr Ser Tyr Lys 
65                  70                  75                  80  


His Ala Ala Ser Gly Phe Ser Ala Lys Leu Thr Ala Glu Gln Val Ser 
                85                  90                  95      


Glu Leu Ser Lys Leu Pro Gly Val Leu Gln Val Val Pro Ser Gln Thr 
            100                 105                 110         


Val Gln Leu His Thr Gly Arg Val 
        115                 120 


<210>  34
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease inhibitor

<400>  34

Met Gln Lys Ile Gln Ile Ile Phe Leu Val Phe Leu Leu Leu Phe Val 
1               5                   10                  15      


Ala Asp Cys Glu Glu Ala Lys Val Tyr Ile Val Phe Thr Glu Asn Pro 
            20                  25                  30          


Gln Pro Lys Glu Phe His Ile Lys Thr Leu Ala Ser Val Leu Gly Ser 
        35                  40                  45              


Glu Asp Ala Ala Arg Glu Ala Leu Ile Tyr Ser Tyr Lys His Val Ile 
    50                  55                  60                  


Ser Gly Phe Ala Ala Arg Leu Thr Pro Glu Gln Val Ser Glu Leu Ala 
65                  70                  75                  80  


Lys Lys Pro Gly Val Leu Glu Ile Val Pro Ser Arg Thr Tyr His Leu 
                85                  90                  95      


Asp Gly Pro Lys Leu Lys 
            100         


