                         SEQUENCE LISTING

<110>  Inserm
 
<120>  USE OF TIM-3 INHIBITORS FOR THE TREATMENT OF EXACERBATIONS IN 
       PATIENTS SUFFERING FROM SEVERE ASTHMA

<130>  BIO18133 DUEZ / MC

<160>  16    

<170>  PatentIn version 3.3

<210>  1
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  2
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  2

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  3
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  3

Tyr Pro Gly Asn Gly Asp 
1               5       


<210>  4
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  4

Val Gly Gly Ala Phe Pro Met Asp Tyr 
1               5                   


<210>  5
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  5

Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
1               5                   10      


<210>  6
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  6

Ala Ala Ser 
1           


<210>  7
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  7

Ser Arg Lys Asp Pro Ser 
1               5       


<210>  8
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  8

Ser Tyr Asn Met His 
1               5   


<210>  9
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  9

Asp Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  10

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln 
1               5                   10                  15  


<210>  11
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  11

Ala Ala Ser Asn Val Glu Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  12

Gln Gln Ser Arg Lys Asp Pro Ser Thr 
1               5                   


<210>  13
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  13

Tyr Pro Gly Ser Gly Asp 
1               5       


<210>  14
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  14

Asp Ile Tyr Pro Gly Ser Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  15

Tyr Pro Gly Gln Gly Asp 
1               5       


<210>  16
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  16

Asp Ile Tyr Pro Gly Gln Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


