                         SEQUENCE LISTING

<110>  Centre for Addiction and Mental Health
 
<120>  Methods for diagnosing or treating post-traumatic stress 
       disorder, and compositions therefor

<130>  08940619WO

<140>  
<141>  

<150>  3,019,970
<151>  2018-10-05

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         


<210>  2
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of N-terminal Region of Human Glucocorticoid 
       Receptor (GR)

<400>  2

Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu 
            420 


<210>  3
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRNT-4 Region of Human Glucocorticoid 
       Receptor (GR)

<400>  3

Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu Leu Ser 
1               5                   10                  15      


Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn Ser Asn 
            20                  25                  30          


Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys Ile Lys 
        35                  40                  45              


Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr Leu Pro 
    50                  55                  60                  


Gln Val Lys Thr Glu Lys 
65                  70  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of S211-L225 Region (GRNT-4-1 Region) of 
       Human Glucocorticoid Receptor (GR)

<400>  4

Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu Leu 
1               5                   10                  15  


<210>  5
<211>  457
<212>  PRT
<213>  Homo Sapiens

<400>  5

Met Thr Thr Asp Glu Gly Ala Lys Asn Asn Glu Glu Ser Pro Thr Ala 
1               5                   10                  15      


Thr Val Ala Glu Gln Gly Glu Asp Ile Thr Ser Lys Lys Asp Arg Gly 
            20                  25                  30          


Val Leu Lys Ile Val Lys Arg Val Gly Asn Gly Glu Glu Thr Pro Met 
        35                  40                  45              


Ile Gly Asp Lys Val Tyr Val His Tyr Lys Gly Lys Leu Ser Asn Gly 
    50                  55                  60                  


Lys Lys Phe Asp Ser Ser His Asp Arg Asn Glu Pro Phe Val Phe Ser 
65                  70                  75                  80  


Leu Gly Lys Gly Gln Val Ile Lys Ala Trp Asp Ile Gly Val Ala Thr 
                85                  90                  95      


Met Lys Lys Gly Glu Ile Cys His Leu Leu Cys Lys Pro Glu Tyr Ala 
            100                 105                 110         


Tyr Gly Ser Ala Gly Ser Leu Pro Lys Ile Pro Ser Asn Ala Thr Leu 
        115                 120                 125             


Phe Phe Glu Ile Glu Leu Leu Asp Phe Lys Gly Glu Asp Leu Phe Glu 
    130                 135                 140                 


Asp Gly Gly Ile Ile Arg Arg Thr Lys Arg Lys Gly Glu Gly Tyr Ser 
145                 150                 155                 160 


Asn Pro Asn Glu Gly Ala Thr Val Glu Ile His Leu Glu Gly Arg Cys 
                165                 170                 175     


Gly Gly Arg Met Phe Asp Cys Arg Asp Val Ala Phe Thr Val Gly Glu 
            180                 185                 190         


Gly Glu Asp His Asp Ile Pro Ile Gly Ile Asp Lys Ala Leu Glu Lys 
        195                 200                 205             


Met Gln Arg Glu Glu Gln Cys Ile Leu Tyr Leu Gly Pro Arg Tyr Gly 
    210                 215                 220                 


Phe Gly Glu Ala Gly Lys Pro Lys Phe Gly Ile Glu Pro Asn Ala Glu 
225                 230                 235                 240 


Leu Ile Tyr Glu Val Thr Leu Lys Ser Phe Glu Lys Ala Lys Glu Ser 
                245                 250                 255     


Trp Glu Met Asp Thr Lys Glu Lys Leu Glu Gln Ala Ala Ile Val Lys 
            260                 265                 270         


Glu Lys Gly Thr Val Tyr Phe Lys Gly Gly Lys Tyr Met Gln Ala Val 
        275                 280                 285             


Ile Gln Tyr Gly Lys Ile Val Ser Trp Leu Glu Met Glu Tyr Gly Leu 
    290                 295                 300                 


Ser Glu Lys Glu Ser Lys Ala Ser Glu Ser Phe Leu Leu Ala Ala Phe 
305                 310                 315                 320 


Leu Asn Leu Ala Met Cys Tyr Leu Lys Leu Arg Glu Tyr Thr Lys Ala 
                325                 330                 335     


Val Glu Cys Cys Asp Lys Ala Leu Gly Leu Asp Ser Ala Asn Glu Lys 
            340                 345                 350         


Gly Leu Tyr Arg Arg Gly Glu Ala Gln Leu Leu Met Asn Glu Phe Glu 
        355                 360                 365             


Ser Ala Lys Gly Asp Phe Glu Lys Val Leu Glu Val Asn Pro Gln Asn 
    370                 375                 380                 


Lys Ala Ala Arg Leu Gln Ile Ser Met Cys Gln Lys Lys Ala Lys Glu 
385                 390                 395                 400 


His Asn Glu Arg Asp Arg Arg Ile Tyr Ala Asn Met Phe Lys Lys Phe 
                405                 410                 415     


Ala Glu Gln Asp Ala Lys Glu Glu Ala Asn Lys Ala Met Gly Lys Lys 
            420                 425                 430         


Thr Ser Glu Gly Val Thr Asn Glu Lys Gly Thr Asp Ser Gln Ala Met 
        435                 440                 445             


Glu Glu Glu Lys Pro Glu Gly His Val 
    450                 455         


<210>  6
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the FKBP51TPR Domain of Human FK506 
       Binding Protein 51 (FKBP51)

<400>  6

Glu Met Asp Thr Lys Glu Lys Leu Glu Gln Ala Ala Ile Val Lys Glu 
1               5                   10                  15      


Lys Gly Thr Val Tyr Phe Lys Gly Gly Lys Tyr Met Gln Ala Val Ile 
            20                  25                  30          


Gln Tyr Gly Lys Ile Val Ser Trp Leu Glu Met Glu Tyr Gly Leu Ser 
        35                  40                  45              


Glu Lys Glu Ser Lys Ala Ser Glu Ser Phe Leu Leu Ala Ala Phe Leu 
    50                  55                  60                  


Asn Leu Ala Met Cys Tyr Leu Lys Leu Arg Glu Tyr Thr Lys Ala Val 
65                  70                  75                  80  


Glu Cys Cys Asp Lys Ala Leu Gly Leu Asp Ser Ala Asn Glu Lys Gly 
                85                  90                  95      


Leu Tyr Arg Arg Gly Glu Ala Gln Leu Leu Met Asn Glu Phe Glu Ser 
            100                 105                 110         


Ala Lys Gly Asp Phe Glu Lys Val Leu Glu Val Asn Pro Gln Asn Lys 
        115                 120                 125             


Ala Ala Arg Leu Gln Ile Ser Met Cys Gln Lys Lys Ala Lys Glu His 
    130                 135                 140                 


Asn Glu Arg Asp Arg Arg Ile Tyr Ala Asn Met Phe Lys Lys Phe Ala 
145                 150                 155                 160 


Glu Gln Asp Ala Lys Glu Glu Ala Asn Lys Ala Met Gly Lys Lys Thr 
                165                 170                 175     


Ser Glu Gly Val Thr Asn Glu Lys Gly Thr Asp Ser Gln Ala Met Glu 
            180                 185                 190         


Glu Glu Lys Pro Glu Gly His Val 
        195                 200 


<210>  7
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the FKBP51TPR3 Domain of Human FK506 
       Binding Protein 51 (FKBP51)

<400>  7

Gly Glu Ala Gln Leu Leu Met Asn Glu Phe Glu Ser Ala Lys Gly Asp 
1               5                   10                  15      


Phe Glu Lys Val Leu Glu Val Asn Pro Gln Asn Lys Ala Ala Arg Leu 
            20                  25                  30          


Gln Ile Ser Met Cys Gln Lys Lys Ala Lys Glu His Asn Glu Arg Asp 
        35                  40                  45              


Arg Arg 
    50  


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the Cell-Membrane Transduction Domain of 
       HIV-Type 1 Transactivator of Transcription (TAT) Protein

<400>  8

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  9
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of TAT-GRpep Peptide

<400>  9

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln Ser Pro Trp Arg 
1               5                   10                  15      


Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu Leu 
            20                  25          


<210>  10
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of S211A GR Mutant (non-phosphorylated GR 
       mutant)

<400>  10

Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ala Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         


<210>  11
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of S211E GR Mutant (phosphomimetic GR mutant)

<400>  11

Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Glu Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         


<210>  12
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRCT Fragment

<400>  12

Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His Tyr Gly Val Leu 
1               5                   10                  15      


Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Val Glu Gly Gln 
            20                  25                  30          


His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile 
        35                  40                  45              


Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys Cys Leu Gln Ala 
    50                  55                  60                  


Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser Glu Asn Pro Gly 
                85                  90                  95      


Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu Thr Pro Thr Leu 
            100                 105                 110         


Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala Gly Tyr 
        115                 120                 125             


Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met Thr Thr Leu Asn 
    130                 135                 140                 


Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala Lys Ala 
145                 150                 155                 160 


Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr Leu Leu 
                165                 170                 175     


Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu Gly Trp Arg Ser 
            180                 185                 190         


Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala Pro Asp Leu Ile 
        195                 200                 205             


Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr Asp Gln Cys Lys 
    210                 215                 220                 


His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu Gln Val Ser Tyr 
225                 230                 235                 240 


Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser Val Pro 
                245                 250                 255     


Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg Met Thr 
            260                 265                 270         


Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly Asn Ser 
        275                 280                 285             


Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser 
    290                 295                 300                 


Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys Phe Gln Thr Phe 
305                 310                 315                 320 


Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met Leu Ala Glu Ile 
                325                 330                 335     


Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn Ile Lys Lys Leu 
            340                 345                 350         


Leu Phe His Gln Lys 
        355         


<210>  13
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRNT-1 Fragment

<400>  13

Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val 
65                  70  


<210>  14
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRNT-2 Fragment

<400>  14

Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys Ala Val Ser Leu Ser Met 
1               5                   10                  15      


Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys Val Met Gly Asn Asp Leu 
            20                  25                  30          


Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu Ser Ser Gly Glu Thr Asp 
        35                  40                  45              


Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn Leu Asn Arg Ser Thr Ser 
    50                  55                  60                  


Val Pro Glu Asn Pro Lys 
65                  70  


<210>  15
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRNT-2 Fragment

<400>  15

Ser Ser Ala Ser Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe 
1               5                   10                  15      


Pro Lys Thr His Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly 
            20                  25                  30          


Gln Thr Gly Thr Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln 
        35                  40                  45              


Ser Thr Phe Asp Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro 
    50                  55                  60                  


Gly Lys Glu Thr Asn Glu 
65                  70  


<210>  16
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRNT-5 Fragment

<400>  16

Glu Asp Phe Ile Glu Leu Cys Thr Pro Gly Val Ile Lys Gln Glu Lys 
1               5                   10                  15      


Leu Gly Thr Val Tyr Cys Gln Ala Ser Phe Pro Gly Ala Asn Ile Ile 
            20                  25                  30          


Gly Asn Lys Met Ser Ala Ile Ser Val His Gly Val Ser Thr Ser Gly 
        35                  40                  45              


Gly Gln Met Tyr His Tyr Asp Met Asn Thr Ala Ser Leu Ser Gln Gln 
    50                  55                  60                  


Gln Asp Gln Lys Pro Ile 
65                  70  


<210>  17
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRNT-6 Fragment

<400>  17

Phe Asn Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg 
1               5                   10                  15      


Cys Gln Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn 
            20                  25                  30          


Phe Pro Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met 
        35                  40                  45              


Arg Pro Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr 
    50                  55                  60                  


Gly Pro Pro Pro Lys Leu 
65                  70  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRNT-4-2 Fragment

<400>  18

Leu Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRNT-4-3 Fragment

<400>  19

Glu Gly Asn Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRNT-4-4 Fragment

<400>  20

Asp Thr Lys Pro Lys Ile Lys Asp Asn Gly Asp Leu Val Leu Ser 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of GRNT-4-5 Fragment

<400>  21

Ser Ser Pro Ser Asn Val Thr Leu Pro Gln Val Lys Thr Glu Lys 
1               5                   10                  15  


<210>  22
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of FKBP51FK1 Fragment

<400>  22

Met Thr Thr Asp Glu Gly Ala Lys Asn Asn Glu Glu Ser Pro Thr Ala 
1               5                   10                  15      


Thr Val Ala Glu Gln Gly Glu Asp Ile Thr Ser Lys Lys Asp Arg Gly 
            20                  25                  30          


Val Leu Lys Ile Val Lys Arg Val Gly Asn Gly Glu Glu Thr Pro Met 
        35                  40                  45              


Ile Gly Asp Lys Val Tyr Val His Tyr Lys Gly Lys Leu Ser Asn Gly 
    50                  55                  60                  


Lys Lys Phe Asp Ser Ser His Asp Arg Asn Glu Pro Phe Val Phe Ser 
65                  70                  75                  80  


Leu Gly Lys Gly Gln Val Ile Lys Ala Trp Asp Ile Gly Val Ala Thr 
                85                  90                  95      


Met Lys Lys Gly Glu Ile Cys His Leu Leu Cys Lys Pro Glu Tyr Ala 
            100                 105                 110         


Tyr Gly Ser Ala Gly Ser Leu Pro Lys Ile Pro Ser Asn Ala Thr Leu 
        115                 120                 125             


Phe Phe Glu Ile Glu Leu Leu Asp Phe Lys Gly Glu Asp Leu Phe 
    130                 135                 140             


<210>  23
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of FKBP51FK2 Fragment

<400>  23

Glu Asp Gly Gly Ile Ile Arg Arg Thr Lys Arg Lys Gly Glu Gly Tyr 
1               5                   10                  15      


Ser Asn Pro Asn Glu Gly Ala Thr Val Glu Ile His Leu Glu Gly Arg 
            20                  25                  30          


Cys Gly Gly Arg Met Phe Asp Cys Arg Asp Val Ala Phe Thr Val Gly 
        35                  40                  45              


Glu Gly Glu Asp His Asp Ile Pro Ile Gly Ile Asp Lys Ala Leu Glu 
    50                  55                  60                  


Lys Met Gln Arg Glu Glu Gln Cys Ile Leu Tyr Leu Gly Pro Arg Tyr 
65                  70                  75                  80  


Gly Phe Gly Glu Ala Gly Lys Pro Lys Phe Gly Ile Glu Pro Asn Ala 
                85                  90                  95      


Glu Leu Ile Tyr Glu Val Thr Leu Lys Ser Phe Glu Lys Ala Lys Glu 
            100                 105                 110         


Ser Trp 
        


<210>  24
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of FKBP51TPR-1 Fragment

<400>  24

Glu Met Asp Thr Lys Glu Lys Leu Glu Gln Ala Ala Ile Val Lys Glu 
1               5                   10                  15      


Lys Gly Thr Val Tyr Phe Lys Gly Gly Lys Tyr Met Gln Ala Val Ile 
            20                  25                  30          


Gln Tyr Gly Lys Ile Val Ser Trp Leu Glu Met Glu Tyr Gly Leu Ser 
        35                  40                  45              


Glu Lys 
    50  


<210>  25
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of FKBP51TPR-2 Fragment

<400>  25

Glu Ser Lys Ala Ser Glu Ser Phe Leu Leu Ala Ala Phe Leu Asn Leu 
1               5                   10                  15      


Ala Met Cys Tyr Leu Lys Leu Arg Glu Tyr Thr Lys Ala Val Glu Cys 
            20                  25                  30          


Cys Asp Lys Ala Leu Gly Leu Asp Ser Ala Asn Glu Lys Gly Leu Tyr 
        35                  40                  45              


Arg Arg 
    50  


<210>  26
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of FKBP51TPR-4 Fragment

<400>  26

Ile Tyr Ala Asn Met Phe Lys Lys Phe Ala Glu Gln Asp Ala Lys Glu 
1               5                   10                  15      


Glu Ala Asn Lys Ala Met Gly Lys Lys Thr Ser Glu Gly Val Thr Asn 
            20                  25                  30          


Glu Lys Gly Thr Asp Ser Gln Ala Met Glu Glu Glu Lys Pro Glu Gly 
        35                  40                  45              


His Val 
    50  


