                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  LIGAND-DIRECTED TARGETING VECTORS

<130>  UCLA.266WOU1

<150>  62/738,695
<151>  2018-09-28

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2.2 1L1L construct

<400>  1
atggcgtccg cagcaccact ggtcacggca atgtgtttgc tcggaaatgt gagcttccca       60

tgcgaccgcc cgcccacatg ctatacccgc gaaccttcca gagccctcga catccttgaa      120

gagaacgtga accatgaggc ctacgatacc ctgctcaatg ccatattgcg gtgcggatcg      180

tctggcagcg tcattgacga ctttaccctg accagcccct acttgggcac atgctcgtac      240

tgccaccata ctgaaccgtg cttcagccct gttaagatcg agcaggtctg ggacgaagcg      300

gacgataaca ccatacgcat acagacttcc gcccagtttg gatacgacca aagcggagca      360

gcaagcgcaa acaagtaccg ctacatggcg gctgcggcgg taacaggcgg aggaggcagc      420

ctaggggtaa ccggaggcgg cggatccgta accaccgtta aagaaggcac catggatgac      480

atcaagatta gcacctcagg accgtgtaga aggcttagct acaaaggata ctttctcctc      540

gcaaaatgcc ctccagggga cagcgtaacg gttagcatag tgagtagcaa ctcagcaacg      600

tcatgtacac tggcccgcaa gataaaacca aaattcgtgg gacgggaaaa atatgatcta      660

cctcccgttc acggtaaaaa aattccttgc acagtgtacg accgtctggc agcaacaact      720

gcaggctaca tcactatgca caggccggga ccgcacgctt atacatccta cctggaagaa      780

tcatcaggga aagtttacgc aaagccgcca tctgggaaga acattacgta tgagtgcaag      840

tgcggcgact acaagaccgg aaccgtttcg acccgcaccg aaatcactgg ttgcaccgcc      900

atcaagcagt gcgtcgccta taagagcgac caaacgaagt gggtcttcaa ctcaccggac      960

ttgatcagac atgacgacca cacggtccaa gggaaattgc atttgccttt caagttgatc     1020

ccgagtacct gcatggtccc tgttgcccac gcgccgaatg taatacatgg ctttaaacac     1080

atcagcctcc aattagatac agaccacttg acattgctca ccaccaggag actaggggca     1140

aacccggaac caaccactga atggatcgtc ggaaagacgg tcagaaactt caccgtcgac     1200

cgagatggcc tggaatacat atggggaaat catgagccag tgagggtcta tgcccaagag     1260

tcagcaccag gagaccctca cggatggcca cacgaaatag tacagcatta ctaccatcgc     1320

catcctgtgt acaccatctt agccgtcgca tcagctaccg tggcgatgat gattggcgta     1380

actgttgcag tgttatgtgc ctgtaaagcg cgccgtgagt gcctgacgcc atacgccctg     1440

gccccaaacg ccgtaatccc aacttcgctg gcactcttgt gctgcgttag gtcggccaat     1500

gctgaaacgt tcaccgagac catgagttac ttgtggtcga acagtcagcc gttcttctgg     1560

gtccagttgt gcataccttt ggccgctttc atcgttctaa tgcgctgctg ctcctgctgc     1620

ctgccttttt tagtggttgc cggcgcctac ctggcgaagg tagacgccta cgaacatgcg     1680

accactgttc caaatgtgcc acagataccg tataaggcac ttgttgaaag ggcagggtat     1740

gccccgctca atttggagat cactgtcatg tcctcggagg ttttgccttc caccaaccaa     1800

gagtacatta cctgcaaatt caccactgtg gtcccctccc caaaaatcaa atgctgcggc     1860

tccttggaat gtcagccggc cgctcatgca ggctatacct gcaaggtctt cggaggggtc     1920

taccccttta tgtggggagg agcgcaatgt ttttgcgaca gtgagaacag ccagatgagt     1980

gaggcgtacg tcgaattgtc agcagattgc gcgtctgacc acgcgcaggc gattaaggtg     2040

cacactgccg cgatgaaagt aggactgcgt attgtgtacg ggaacactac cagtttccta     2100

gatgtgtacg tgaacggagt cacaccagga acgtctaaag acttgaaagt catagctgga     2160

ccaatttcag catcgtttac gccattcgat cataaggtcg ttatccatcg cggcctggtg     2220

tacaactatg acttcccgga atatggagcg atgaaaccag gagcgtttgg agacattcaa     2280

gctacctcct tgactagcaa ggatctcatc gccagcacag acattaggct actcaagcct     2340

tcctcaggaa acgtgcatgt cccgtacacg caggcctcat caggatttga gatgtggaaa     2400

aacaactcag gccgcccact gcaggaaacc gcacctttcg ggtgtaagat tgcagtaaat     2460

ccgctccgag cggtggactg ttcatacggg aacattccca tttctattga catcccgaac     2520

gctgccttta tcaggacatc agatgcacca ctggtctcaa cagtcaaatg tgaagtcagt     2580

gagtgcactt attcagcaga cttcggcggg atggccaccc tgcagtatgt atccgaccgc     2640

gaaggtcaat gccccgtaca ttcgcattcg agcacagcaa ctctccaaga gtcgacagta     2700

catgtcctgg agaaaggagc ggtgacagta cactttagca ccgcgagtcc acaggcgaac     2760

tttatcgtat cgctgtgtgg gaagaagaca acatgcaatg cagaatgtaa accaccagct     2820

gaccatatcg tgagcacccc gcacaaaaat gaccaagaat ttcaagccgc catctcaaaa     2880

acatcatgga gttggctgtt tgcccttttc ggcggcgcct cgtcgctatt aattatagga     2940

cttatgattt ttgcttgcag catgatgctg actagcacac gaagatga                  2988


<210>  2
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.2 1L1L construct

<400>  2

Met Ala Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn 
1               5                   10                  15      


Val Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro 
            20                  25                  30          


Ser Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr 
        35                  40                  45              


Asp Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Ser Val 
    50                  55                  60                  


Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr Cys Ser Tyr 
65                  70                  75                  80  


Cys His His Thr Glu Pro Cys Phe Ser Pro Val Lys Ile Glu Gln Val 
                85                  90                  95      


Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr Ser Ala Gln 
            100                 105                 110         


Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys Tyr Arg Tyr 
        115                 120                 125             


Met Ala Ala Ala Ala Val Thr Gly Gly Gly Gly Ser Leu Gly Val Thr 
    130                 135                 140                 


Gly Gly Gly Gly Ser Val Thr Thr Val Lys Glu Gly Thr Met Asp Asp 
145                 150                 155                 160 


Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser Tyr Lys Gly 
                165                 170                 175     


Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val Thr Val Ser 
            180                 185                 190         


Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala Arg Lys Ile 
        195                 200                 205             


Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro Pro Val His 
    210                 215                 220                 


Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Ala Ala Thr Thr 
225                 230                 235                 240 


Ala Gly Tyr Ile Thr Met His Arg Pro Gly Pro His Ala Tyr Thr Ser 
                245                 250                 255     


Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro Ser Gly 
            260                 265                 270         


Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr Gly Thr 
        275                 280                 285             


Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys Gln Cys 
    290                 295                 300                 


Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser Pro Asp 
305                 310                 315                 320 


Leu Ile Arg His Asp Asp His Thr Val Gln Gly Lys Leu His Leu Pro 
                325                 330                 335     


Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His Ala Pro 
            340                 345                 350         


Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp Thr Asp 
        355                 360                 365             


His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro Glu Pro 
    370                 375                 380                 


Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr Val Asp 
385                 390                 395                 400 


Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val Arg Val 
                405                 410                 415     


Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro His Glu 
            420                 425                 430         


Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile Leu Ala 
        435                 440                 445             


Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val Ala Val 
    450                 455                 460                 


Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr Ala Leu 
465                 470                 475                 480 


Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys Cys Val 
                485                 490                 495     


Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser Tyr Leu Trp 
            500                 505                 510         


Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile Pro Leu Ala 
        515                 520                 525             


Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu Pro Phe Leu 
    530                 535                 540                 


Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr Glu His Ala 
545                 550                 555                 560 


Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala Leu Val Glu 
                565                 570                 575     


Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Met Ser Ser 
            580                 585                 590         


Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys Lys Phe Thr 
        595                 600                 605             


Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser Leu Glu Cys 
    610                 615                 620                 


Gln Pro Ala Ala His Ala Gly Tyr Thr Cys Lys Val Phe Gly Gly Val 
625                 630                 635                 640 


Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser Glu Asn 
                645                 650                 655     


Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp Cys Ala Ser 
            660                 665                 670         


Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met Lys Val Gly 
        675                 680                 685             


Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp Val Tyr Val 
    690                 695                 700                 


Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val Ile Ala Gly 
705                 710                 715                 720 


Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val Val Ile His 
                725                 730                 735     


Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala Met Lys 
            740                 745                 750         


Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr Ser Lys Asp 
        755                 760                 765             


Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser Ser Gly Asn 
    770                 775                 780                 


Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu Met Trp Lys 
785                 790                 795                 800 


Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly Cys Lys 
                805                 810                 815     


Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr Gly Asn Ile 
            820                 825                 830         


Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg Thr Ser Asp 
        835                 840                 845             


Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu Cys Thr Tyr 
    850                 855                 860                 


Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val Ser Asp Arg 
865                 870                 875                 880 


Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala Thr Leu Gln 
                885                 890                 895     


Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr Val His Phe 
            900                 905                 910         


Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu Cys Gly Lys 
        915                 920                 925             


Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp His Ile Val 
    930                 935                 940                 


Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala Ile Ser Lys 
945                 950                 955                 960 


Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala Ser Ser Leu 
                965                 970                 975     


Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met Leu Thr Ser 
            980                 985                 990         


Thr Arg Arg 
        995 


<210>  3
<211>  3327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2.2 construct

<400>  3
atggcgtccg cagcaccact ggtcacggca atgtgtttgc tcggaaatgt gagcttccca       60

tgcgaccgcc cgcccacatg ctatacccgc gaaccttcca gagccctcga catccttgaa      120

gagaacgtga accatgaggc ctacgatacc ctgctcaatg ccatattgcg gtgcggatcg      180

tctggcagcg tcattgacga ctttaccctg accagcccct acttgggcac atgctcgtac      240

tgccaccata ctgaaccgtg cttcagccct gttaagatcg agcaggtctg ggacgaagcg      300

gacgataaca ccatacgcat acagacttcc gcccagtttg gatacgacca aagcggagca      360

gcaagcgcaa acaagtaccg ctacatggcg gctgcggcgg taaccgacaa caaattcaac      420

aaagaacaac aaaacgcgtt ctatgagatc ttacatttac ctaacttaaa cgaagaacaa      480

cgaaacgcct tcatccaaag tttaaaagat gacccaagcc aaagcgctaa ccttttagca      540

gaagctaaaa agctaaatga tgctcaggcg ccgaaagtag acaacaaatt caacaaagaa      600

caacaaaacg cgttctatga gatcttacat ttacctaact taaacgaaga acaacgaaac      660

gccttcatcc aaagtttaaa agatgaccca agccaaagcg ctaacctttt agcagaagct      720

aaaaagctaa atgatgctca ggcgccgaaa gtagacgcga attcgagctc ggtacccggg      780

gatccggtaa ccaccgttaa agaaggcacc atggatgaca tcaagattag cacctcagga      840

ccgtgtagaa ggcttagcta caaaggatac tttctcctcg caaaatgccc tccaggggac      900

agcgtaacgg ttagcatagt gagtagcaac tcagcaacgt catgtacact ggcccgcaag      960

ataaaaccaa aattcgtggg acgggaaaaa tatgatctac ctcccgttca cggtaaaaaa     1020

attccttgca cagtgtacga ccgtctggca gcaacaactg caggctacat cactatgcac     1080

aggccgggac cgcacgctta tacatcctac ctggaagaat catcagggaa agtttacgca     1140

aagccgccat ctgggaagaa cattacgtat gagtgcaagt gcggcgacta caagaccgga     1200

accgtttcga cccgcaccga aatcactggt tgcaccgcca tcaagcagtg cgtcgcctat     1260

aagagcgacc aaacgaagtg ggtcttcaac tcaccggact tgatcagaca tgacgaccac     1320

acggtccaag ggaaattgca tttgcctttc aagttgatcc cgagtacctg catggtccct     1380

gttgcccacg cgccgaatgt aatacatggc tttaaacaca tcagcctcca attagataca     1440

gaccacttga cattgctcac caccaggaga ctaggggcaa acccggaacc aaccactgaa     1500

tggatcgtcg gaaagacggt cagaaacttc accgtcgacc gagatggcct ggaatacata     1560

tggggaaatc atgagccagt gagggtctat gcccaagagt cagcaccagg agaccctcac     1620

ggatggccac acgaaatagt acagcattac taccatcgcc atcctgtgta caccatctta     1680

gccgtcgcat cagctaccgt ggcgatgatg attggcgtaa ctgttgcagt gttatgtgcc     1740

tgtaaagcgc gccgtgagtg cctgacgcca tacgccctgg ccccaaacgc cgtaatccca     1800

acttcgctgg cactcttgtg ctgcgttagg tcggccaatg ctgaaacgtt caccgagacc     1860

atgagttact tgtggtcgaa cagtcagccg ttcttctggg tccagttgtg catacctttg     1920

gccgctttca tcgttctaat gcgctgctgc tcctgctgcc tgcctttttt agtggttgcc     1980

ggcgcctacc tggcgaaggt agacgcctac gaacatgcga ccactgttcc aaatgtgcca     2040

cagataccgt ataaggcact tgttgaaagg gcagggtatg ccccgctcaa tttggagatc     2100

actgtcatgt cctcggaggt tttgccttcc accaaccaag agtacattac ctgcaaattc     2160

accactgtgg tcccctcccc aaaaatcaaa tgctgcggct ccttggaatg tcagccggcc     2220

gctcatgcag gctatacctg caaggtcttc ggaggggtct acccctttat gtggggagga     2280

gcgcaatgtt tttgcgacag tgagaacagc cagatgagtg aggcgtacgt cgaattgtca     2340

gcagattgcg cgtctgacca cgcgcaggcg attaaggtgc acactgccgc gatgaaagta     2400

ggactgcgta ttgtgtacgg gaacactacc agtttcctag atgtgtacgt gaacggagtc     2460

acaccaggaa cgtctaaaga cttgaaagtc atagctggac caatttcagc atcgtttacg     2520

ccattcgatc ataaggtcgt tatccatcgc ggcctggtgt acaactatga cttcccggaa     2580

tatggagcga tgaaaccagg agcgtttgga gacattcaag ctacctcctt gactagcaag     2640

gatctcatcg ccagcacaga cattaggcta ctcaagcctt cctcaggaaa cgtgcatgtc     2700

ccgtacacgc aggcctcatc aggatttgag atgtggaaaa acaactcagg ccgcccactg     2760

caggaaaccg cacctttcgg gtgtaagatt gcagtaaatc cgctccgagc ggtggactgt     2820

tcatacggga acattcccat ttctattgac atcccgaacg ctgcctttat caggacatca     2880

gatgcaccac tggtctcaac agtcaaatgt gaagtcagtg agtgcactta ttcagcagac     2940

ttcggcggga tggccaccct gcagtatgta tccgaccgcg aaggtcaatg ccccgtacat     3000

tcgcattcga gcacagcaac tctccaagag tcgacagtac atgtcctgga gaaaggagcg     3060

gtgacagtac actttagcac cgcgagtcca caggcgaact ttatcgtatc gctgtgtggg     3120

aagaagacaa catgcaatgc agaatgtaaa ccaccagctg accatatcgt gagcaccccg     3180

cacaaaaatg accaagaatt tcaagccgcc atctcaaaaa catcatggag ttggctgttt     3240

gcccttttcg gcggcgcctc gtcgctatta attataggac ttatgatttt tgcttgcagc     3300

atgatgctga ctagcacacg aagatga                                         3327


<210>  4
<211>  1108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.2 vector construct

<400>  4

Met Ala Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn 
1               5                   10                  15      


Val Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro 
            20                  25                  30          


Ser Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr 
        35                  40                  45              


Asp Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Ser Val 
    50                  55                  60                  


Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr Cys Ser Tyr 
65                  70                  75                  80  


Cys His His Thr Glu Pro Cys Phe Ser Pro Val Lys Ile Glu Gln Val 
                85                  90                  95      


Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr Ser Ala Gln 
            100                 105                 110         


Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys Tyr Arg Tyr 
        115                 120                 125             


Met Ala Ala Ala Ala Val Thr Asp Asn Lys Phe Asn Lys Glu Gln Gln 
    130                 135                 140                 


Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln 
145                 150                 155                 160 


Arg Asn Ala Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala 
                165                 170                 175     


Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
            180                 185                 190         


Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
        195                 200                 205             


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile Gln 
    210                 215                 220                 


Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
225                 230                 235                 240 


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Val Asp Ala Asn Ser Ser 
                245                 250                 255     


Ser Val Pro Gly Asp Pro Val Thr Thr Val Lys Glu Gly Thr Met Asp 
            260                 265                 270         


Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser Tyr Lys 
        275                 280                 285             


Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val Thr Val 
    290                 295                 300                 


Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala Arg Lys 
305                 310                 315                 320 


Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro Pro Val 
                325                 330                 335     


His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Ala Ala Thr 
            340                 345                 350         


Thr Ala Gly Tyr Ile Thr Met His Arg Pro Gly Pro His Ala Tyr Thr 
        355                 360                 365             


Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro Ser 
    370                 375                 380                 


Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr Gly 
385                 390                 395                 400 


Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys Gln 
                405                 410                 415     


Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser Pro 
            420                 425                 430         


Asp Leu Ile Arg His Asp Asp His Thr Val Gln Gly Lys Leu His Leu 
        435                 440                 445             


Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His Ala 
    450                 455                 460                 


Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp Thr 
465                 470                 475                 480 


Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro Glu 
                485                 490                 495     


Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr Val 
            500                 505                 510         


Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val Arg 
        515                 520                 525             


Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro His 
    530                 535                 540                 


Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile Leu 
545                 550                 555                 560 


Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val Ala 
                565                 570                 575     


Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr Ala 
            580                 585                 590         


Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys Cys 
        595                 600                 605             


Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser Tyr Leu 
    610                 615                 620                 


Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile Pro Leu 
625                 630                 635                 640 


Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu Pro Phe 
                645                 650                 655     


Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr Glu His 
            660                 665                 670         


Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala Leu Val 
        675                 680                 685             


Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Met Ser 
    690                 695                 700                 


Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys Lys Phe 
705                 710                 715                 720 


Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser Leu Glu 
                725                 730                 735     


Cys Gln Pro Ala Ala His Ala Gly Tyr Thr Cys Lys Val Phe Gly Gly 
            740                 745                 750         


Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser Glu 
        755                 760                 765             


Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp Cys Ala 
    770                 775                 780                 


Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met Lys Val 
785                 790                 795                 800 


Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp Val Tyr 
                805                 810                 815     


Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val Ile Ala 
            820                 825                 830         


Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val Val Ile 
        835                 840                 845             


His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala Met 
    850                 855                 860                 


Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr Ser Lys 
865                 870                 875                 880 


Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser Ser Gly 
                885                 890                 895     


Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu Met Trp 
            900                 905                 910         


Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly Cys 
        915                 920                 925             


Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr Gly Asn 
    930                 935                 940                 


Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg Thr Ser 
945                 950                 955                 960 


Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu Cys Thr 
                965                 970                 975     


Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val Ser Asp 
            980                 985                 990         


Arg Glu Gly Gln Cys Pro Val His  Ser His Ser Ser Thr  Ala Thr Leu 
        995                 1000                 1005             


Gln Glu  Ser Thr Val His Val  Leu Glu Lys Gly Ala  Val Thr Val 
    1010                 1015                 1020             


His Phe  Ser Thr Ala Ser Pro  Gln Ala Asn Phe Ile  Val Ser Leu 
    1025                 1030                 1035             


Cys Gly  Lys Lys Thr Thr Cys  Asn Ala Glu Cys Lys  Pro Pro Ala 
    1040                 1045                 1050             


Asp His  Ile Val Ser Thr Pro  His Lys Asn Asp Gln  Glu Phe Gln 
    1055                 1060                 1065             


Ala Ala  Ile Ser Lys Thr Ser  Trp Ser Trp Leu Phe  Ala Leu Phe 
    1070                 1075                 1080             


Gly Gly  Ala Ser Ser Leu Leu  Ile Ile Gly Leu Met  Ile Phe Ala 
    1085                 1090                 1095             


Cys Ser  Met Met Leu Thr Ser  Thr Arg Arg 
    1100                 1105             


<210>  5
<211>  3567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E2 71 eMA vector construct

<400>  5
atggcgtccg cagcaccact ggtcacggca atgtgtttgc tcggaaatgt gagcttccca       60

tgcgaccgcc cgcccacatg ctatacccgc gaaccttcca gagccctcga catccttgaa      120

gagaacgtga accatgaggc ctacgatacc ctgctcaatg ccatattgcg gtgcggatcg      180

tctggcagcg tcattgacga ctttaccctg accagcccct acttgggcac atgctcgtac      240

tgccaccata ctgaaccgtg cttcagccct gttaagatcg agcaggtctg ggacgaagcg      300

gacgataaca ccatacgcat acagacttcc gcccagtttg gatacgacca aagcggagca      360

gcaagcgcaa acaagtaccg ctacatggcg gctgcggcgg taacaggcgg aggaggcagc      420

ctaggcgtga ccagcagcgg ctctggatct ggcggaggcg gaggaagtgg agggggagga      480

agcggcggag ggggctctgc tagcttcgac gcctccaatt tcaaggactt cagcagcatc      540

gcctctgcct ctagctcctg gcagaaccag cacggcagca ccatgatcat ccaggtggac      600

tcttttggca atgtgagcgg acagtacgtg aacagggccg agggcacagg atgccagaat      660

tccccctatc ctctgaccgg cagagtgaac ggcaccttca tcgacttcag cgtgaagtgg      720

aacaattcta ccgagaactg taatagcaac acccagtgga caggctacgc ccaagtgaat      780

ggcaacaata ccgagatcgt gacacggtgg aacctgaagt acgagggagg atctggacca      840

gcaatctggc agggccagga cacattccag tatgtgccca ccacagaaat cgatgctggc      900

gggggaggct ctggaagtgg atctgggggt ggcggcggaa gctctggatc tggaagcgga      960

gggggaggca gcggcagtgg atcagggggg ggagggggat ctctggtaac cggaggcggc     1020

ggatccgtaa ccaccgttaa agaaggcacc atggatgaca tcaagattag cacctcagga     1080

ccgtgtagaa ggcttagcta caaaggatac tttctcctcg caaaatgccc tccaggggac     1140

agcgtaacgg ttagcatagt gagtagcaac tcagcaacgt catgtacact ggcccgcaag     1200

ataaaaccaa aattcgtggg acgggaaaaa tatgatctac ctcccgttca cggtaaaaaa     1260

attccttgca cagtgtacga ccgtctggca gcaacaactg caggctacat cactatgcac     1320

aggccgggac cgcacgctta tacatcctac ctggaagaat catcagggaa agtttacgca     1380

aagccgccat ctgggaagaa cattacgtat gagtgcaagt gcggcgacta caagaccgga     1440

accgtttcga cccgcaccga aatcactggt tgcaccgcca tcaagcagtg cgtcgcctat     1500

aagagcgacc aaacgaagtg ggtcttcaac tcaccggact tgatcagaca tgacgaccac     1560

acggtccaag ggaaattgca tttgcctttc aagttgatcc cgagtacctg catggtccct     1620

gttgcccacg cgccgaatgt aatacatggc tttaaacaca tcagcctcca attagataca     1680

gaccacttga cattgctcac caccaggaga ctaggggcaa acccggaacc aaccactgaa     1740

tggatcgtcg gaaagacggt cagaaacttc accgtcgacc gagatggcct ggaatacata     1800

tggggaaatc atgagccagt gagggtctat gcccaagagt cagcaccagg agaccctcac     1860

ggatggccac acgaaatagt acagcattac taccatcgcc atcctgtgta caccatctta     1920

gccgtcgcat cagctaccgt ggcgatgatg attggcgtaa ctgttgcagt gttatgtgcc     1980

tgtaaagcgc gccgtgagtg cctgacgcca tacgccctgg ccccaaacgc cgtaatccca     2040

acttcgctgg cactcttgtg ctgcgttagg tcggccaatg ctgaaacgtt caccgagacc     2100

atgagttact tgtggtcgaa cagtcagccg ttcttctggg tccagttgtg catacctttg     2160

gccgctttca tcgttctaat gcgctgctgc tcctgctgcc tgcctttttt agtggttgcc     2220

ggcgcctacc tggcgaaggt agacgcctac gaacatgcga ccactgttcc aaatgtgcca     2280

cagataccgt ataaggcact tgttgaaagg gcagggtatg ccccgctcaa tttggagatc     2340

actgtcatgt cctcggaggt tttgccttcc accaaccaag agtacattac ctgcaaattc     2400

accactgtgg tcccctcccc aaaaatcaaa tgctgcggct ccttggaatg tcagccggcc     2460

gctcatgcag gctatacctg caaggtcttc ggaggggtct acccctttat gtggggagga     2520

gcgcaatgtt tttgcgacag tgagaacagc cagatgagtg aggcgtacgt cgaattgtca     2580

gcagattgcg cgtctgacca cgcgcaggcg attaaggtgc acactgccgc gatgaaagta     2640

ggactgcgta ttgtgtacgg gaacactacc agtttcctag atgtgtacgt gaacggagtc     2700

acaccaggaa cgtctaaaga cttgaaagtc atagctggac caatttcagc atcgtttacg     2760

ccattcgatc ataaggtcgt tatccatcgc ggcctggtgt acaactatga cttcccggaa     2820

tatggagcga tgaaaccagg agcgtttgga gacattcaag ctacctcctt gactagcaag     2880

gatctcatcg ccagcacaga cattaggcta ctcaagcctt cctcaggaaa cgtgcatgtc     2940

ccgtacacgc aggcctcatc aggatttgag atgtggaaaa acaactcagg ccgcccactg     3000

caggaaaccg cacctttcgg gtgtaagatt gcagtaaatc cgctccgagc ggtggactgt     3060

tcatacggga acattcccat ttctattgac atcccgaacg ctgcctttat caggacatca     3120

gatgcaccac tggtctcaac agtcaaatgt gaagtcagtg agtgcactta ttcagcagac     3180

ttcggcggga tggccaccct gcagtatgta tccgaccgcg aaggtcaatg ccccgtacat     3240

tcgcattcga gcacagcaac tctccaagag tcgacagtac atgtcctgga gaaaggagcg     3300

gtgacagtac actttagcac cgcgagtcca caggcgaact ttatcgtatc gctgtgtggg     3360

aagaagacaa catgcaatgc agaatgtaaa ccaccagctg accatatcgt gagcaccccg     3420

cacaaaaatg accaagaatt tcaagccgcc atctcaaaaa catcatggag ttggctgttt     3480

gcccttttcg gcggcgcctc gtcgctatta attataggac ttatgatttt tgcttgcagc     3540

atgatgctga ctagcacacg aagatga                                         3567


<210>  6
<211>  1188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vector construct

<400>  6

Met Ala Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn 
1               5                   10                  15      


Val Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro 
            20                  25                  30          


Ser Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr 
        35                  40                  45              


Asp Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Ser Val 
    50                  55                  60                  


Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr Cys Ser Tyr 
65                  70                  75                  80  


Cys His His Thr Glu Pro Cys Phe Ser Pro Val Lys Ile Glu Gln Val 
                85                  90                  95      


Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr Ser Ala Gln 
            100                 105                 110         


Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys Tyr Arg Tyr 
        115                 120                 125             


Met Ala Ala Ala Ala Val Thr Gly Gly Gly Gly Ser Leu Gly Val Thr 
    130                 135                 140                 


Ser Ser Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Ala Ser Phe Asp Ala Ser Asn Phe Lys Asp 
                165                 170                 175     


Phe Ser Ser Ile Ala Ser Ala Ser Ser Ser Trp Gln Asn Gln His Gly 
            180                 185                 190         


Ser Thr Met Ile Ile Gln Val Asp Ser Phe Gly Asn Val Ser Gly Gln 
        195                 200                 205             


Tyr Val Asn Arg Ala Glu Gly Thr Gly Cys Gln Asn Ser Pro Tyr Pro 
    210                 215                 220                 


Leu Thr Gly Arg Val Asn Gly Thr Phe Ile Asp Phe Ser Val Lys Trp 
225                 230                 235                 240 


Asn Asn Ser Thr Glu Asn Cys Asn Ser Asn Thr Gln Trp Thr Gly Tyr 
                245                 250                 255     


Ala Gln Val Asn Gly Asn Asn Thr Glu Ile Val Thr Arg Trp Asn Leu 
            260                 265                 270         


Lys Tyr Glu Gly Gly Ser Gly Pro Ala Ile Trp Gln Gly Gln Asp Thr 
        275                 280                 285             


Phe Gln Tyr Val Pro Thr Thr Glu Ile Asp Ala Gly Gly Gly Gly Ser 
    290                 295                 300                 


Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser Ser Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser Leu Val 
                325                 330                 335     


Thr Gly Gly Gly Gly Ser Val Thr Thr Val Lys Glu Gly Thr Met Asp 
            340                 345                 350         


Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser Tyr Lys 
        355                 360                 365             


Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val Thr Val 
    370                 375                 380                 


Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala Arg Lys 
385                 390                 395                 400 


Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro Pro Val 
                405                 410                 415     


His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Ala Ala Thr 
            420                 425                 430         


Thr Ala Gly Tyr Ile Thr Met His Arg Pro Gly Pro His Ala Tyr Thr 
        435                 440                 445             


Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro Ser 
    450                 455                 460                 


Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr Gly 
465                 470                 475                 480 


Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys Gln 
                485                 490                 495     


Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser Pro 
            500                 505                 510         


Asp Leu Ile Arg His Asp Asp His Thr Val Gln Gly Lys Leu His Leu 
        515                 520                 525             


Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His Ala 
    530                 535                 540                 


Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp Thr 
545                 550                 555                 560 


Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro Glu 
                565                 570                 575     


Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr Val 
            580                 585                 590         


Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val Arg 
        595                 600                 605             


Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro His 
    610                 615                 620                 


Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile Leu 
625                 630                 635                 640 


Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val Ala 
                645                 650                 655     


Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr Ala 
            660                 665                 670         


Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys Cys 
        675                 680                 685             


Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser Tyr Leu 
    690                 695                 700                 


Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile Pro Leu 
705                 710                 715                 720 


Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu Pro Phe 
                725                 730                 735     


Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr Glu His 
            740                 745                 750         


Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala Leu Val 
        755                 760                 765             


Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Met Ser 
    770                 775                 780                 


Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys Lys Phe 
785                 790                 795                 800 


Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser Leu Glu 
                805                 810                 815     


Cys Gln Pro Ala Ala His Ala Gly Tyr Thr Cys Lys Val Phe Gly Gly 
            820                 825                 830         


Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser Glu 
        835                 840                 845             


Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp Cys Ala 
    850                 855                 860                 


Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met Lys Val 
865                 870                 875                 880 


Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp Val Tyr 
                885                 890                 895     


Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val Ile Ala 
            900                 905                 910         


Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val Val Ile 
        915                 920                 925             


His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala Met 
    930                 935                 940                 


Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr Ser Lys 
945                 950                 955                 960 


Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser Ser Gly 
                965                 970                 975     


Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu Met Trp 
            980                 985                 990         


Lys Asn Asn Ser Gly Arg Pro Leu  Gln Glu Thr Ala Pro  Phe Gly Cys 
        995                 1000                 1005             


Lys Ile  Ala Val Asn Pro Leu  Arg Ala Val Asp Cys  Ser Tyr Gly 
    1010                 1015                 1020             


Asn Ile  Pro Ile Ser Ile Asp  Ile Pro Asn Ala Ala  Phe Ile Arg 
    1025                 1030                 1035             


Thr Ser  Asp Ala Pro Leu Val  Ser Thr Val Lys Cys  Glu Val Ser 
    1040                 1045                 1050             


Glu Cys  Thr Tyr Ser Ala Asp  Phe Gly Gly Met Ala  Thr Leu Gln 
    1055                 1060                 1065             


Tyr Val  Ser Asp Arg Glu Gly  Gln Cys Pro Val His  Ser His Ser 
    1070                 1075                 1080             


Ser Thr  Ala Thr Leu Gln Glu  Ser Thr Val His Val  Leu Glu Lys 
    1085                 1090                 1095             


Gly Ala  Val Thr Val His Phe  Ser Thr Ala Ser Pro  Gln Ala Asn 
    1100                 1105                 1110             


Phe Ile  Val Ser Leu Cys Gly  Lys Lys Thr Thr Cys  Asn Ala Glu 
    1115                 1120                 1125             


Cys Lys  Pro Pro Ala Asp His  Ile Val Ser Thr Pro  His Lys Asn 
    1130                 1135                 1140             


Asp Gln  Glu Phe Gln Ala Ala  Ile Ser Lys Thr Ser  Trp Ser Trp 
    1145                 1150                 1155             


Leu Phe  Ala Leu Phe Gly Gly  Ala Ser Ser Leu Leu  Ile Ile Gly 
    1160                 1165                 1170             


Leu Met  Ile Phe Ala Cys Ser  Met Met Leu Thr Ser  Thr Arg Arg 
    1175                 1180                 1185             


<210>  7
<211>  3525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector construct

<400>  7
atggcgtccg cagcaccact ggtcacggca atgtgtttgc tcggaaatgt gagcttccca       60

tgcgaccgcc cgcccacatg ctatacccgc gaaccttcca gagccctcga catccttgaa      120

gagaacgtga accatgaggc ctacgatacc ctgctcaatg ccatattgcg gtgcggatcg      180

tctggcagcg tcattgacga ctttaccctg accagcccct acttgggcac atgctcgtac      240

tgccaccata ctgaaccgtg cttcagccct gttaagatcg agcaggtctg ggacgaagcg      300

gacgataaca ccatacgcat acagacttcc gcccagtttg gatacgacca aagcggagca      360

gcaagcgcaa acaagtaccg ctacatggcg gctgcggcgg taacaggcgg aggaggcagc      420

ctaggcgtga ccagcagcgg ctctggatct ggcggaggcg gaggaagtgg agggggagga      480

agcggcggag ggggctctgc tagcgccgag gccggcatca ccggcacatg gtacaaccag      540

cacggctcta ccttcacagt gaccgcagga gcagacggaa acctgacagg acagtatgag      600

aatagggcac agggaaccgg atgccagaac agcccctaca cactgaccgg caggtataat      660

ggcacaaagc tggagtggcg cgtggagtgg aacaatagca cagagaattg tcactcccgg      720

accgagtgga gaggacagta ccagggagga gccgaggcca ggatcaacac acagtggaat      780

ctgacctatg agggaggaag cggacctgca accgagcagg gccaggatac cttcaccaag      840

gtgaaaatcg atgctggcgg gggaggctct ggaagtggat ctgggggtgg cggcggaagc      900

tctggatctg gaagcggagg gggaggcagc ggcagtggat cagggggggg agggggatct      960

ctggtaaccg gaggcggcgg atccgtaacc accgttaaag aaggcaccat ggatgacatc     1020

aagattagca cctcaggacc gtgtagaagg cttagctaca aaggatactt tctcctcgca     1080

aaatgccctc caggggacag cgtaacggtt agcatagtga gtagcaactc agcaacgtca     1140

tgtacactgg cccgcaagat aaaaccaaaa ttcgtgggac gggaaaaata tgatctacct     1200

cccgttcacg gtaaaaaaat tccttgcaca gtgtacgacc gtctggcagc aacaactgca     1260

ggctacatca ctatgcacag gccgggaccg cacgcttata catcctacct ggaagaatca     1320

tcagggaaag tttacgcaaa gccgccatct gggaagaaca ttacgtatga gtgcaagtgc     1380

ggcgactaca agaccggaac cgtttcgacc cgcaccgaaa tcactggttg caccgccatc     1440

aagcagtgcg tcgcctataa gagcgaccaa acgaagtggg tcttcaactc accggacttg     1500

atcagacatg acgaccacac ggtccaaggg aaattgcatt tgcctttcaa gttgatcccg     1560

agtacctgca tggtccctgt tgcccacgcg ccgaatgtaa tacatggctt taaacacatc     1620

agcctccaat tagatacaga ccacttgaca ttgctcacca ccaggagact aggggcaaac     1680

ccggaaccaa ccactgaatg gatcgtcgga aagacggtca gaaacttcac cgtcgaccga     1740

gatggcctgg aatacatatg gggaaatcat gagccagtga gggtctatgc ccaagagtca     1800

gcaccaggag accctcacgg atggccacac gaaatagtac agcattacta ccatcgccat     1860

cctgtgtaca ccatcttagc cgtcgcatca gctaccgtgg cgatgatgat tggcgtaact     1920

gttgcagtgt tatgtgcctg taaagcgcgc cgtgagtgcc tgacgccata cgccctggcc     1980

ccaaacgccg taatcccaac ttcgctggca ctcttgtgct gcgttaggtc ggccaatgct     2040

gaaacgttca ccgagaccat gagttacttg tggtcgaaca gtcagccgtt cttctgggtc     2100

cagttgtgca tacctttggc cgctttcatc gttctaatgc gctgctgctc ctgctgcctg     2160

ccttttttag tggttgccgg cgcctacctg gcgaaggtag acgcctacga acatgcgacc     2220

actgttccaa atgtgccaca gataccgtat aaggcacttg ttgaaagggc agggtatgcc     2280

ccgctcaatt tggagatcac tgtcatgtcc tcggaggttt tgccttccac caaccaagag     2340

tacattacct gcaaattcac cactgtggtc ccctccccaa aaatcaaatg ctgcggctcc     2400

ttggaatgtc agccggccgc tcatgcaggc tatacctgca aggtcttcgg aggggtctac     2460

ccctttatgt ggggaggagc gcaatgtttt tgcgacagtg agaacagcca gatgagtgag     2520

gcgtacgtcg aattgtcagc agattgcgcg tctgaccacg cgcaggcgat taaggtgcac     2580

actgccgcga tgaaagtagg actgcgtatt gtgtacggga acactaccag tttcctagat     2640

gtgtacgtga acggagtcac accaggaacg tctaaagact tgaaagtcat agctggacca     2700

atttcagcat cgtttacgcc attcgatcat aaggtcgtta tccatcgcgg cctggtgtac     2760

aactatgact tcccggaata tggagcgatg aaaccaggag cgtttggaga cattcaagct     2820

acctccttga ctagcaagga tctcatcgcc agcacagaca ttaggctact caagccttcc     2880

tcaggaaacg tgcatgtccc gtacacgcag gcctcatcag gatttgagat gtggaaaaac     2940

aactcaggcc gcccactgca ggaaaccgca cctttcgggt gtaagattgc agtaaatccg     3000

ctccgagcgg tggactgttc atacgggaac attcccattt ctattgacat cccgaacgct     3060

gcctttatca ggacatcaga tgcaccactg gtctcaacag tcaaatgtga agtcagtgag     3120

tgcacttatt cagcagactt cggcgggatg gccaccctgc agtatgtatc cgaccgcgaa     3180

ggtcaatgcc ccgtacattc gcattcgagc acagcaactc tccaagagtc gacagtacat     3240

gtcctggaga aaggagcggt gacagtacac tttagcaccg cgagtccaca ggcgaacttt     3300

atcgtatcgc tgtgtgggaa gaagacaaca tgcaatgcag aatgtaaacc accagctgac     3360

catatcgtga gcaccccgca caaaaatgac caagaatttc aagccgccat ctcaaaaaca     3420

tcatggagtt ggctgtttgc ccttttcggc ggcgcctcgt cgctattaat tataggactt     3480

atgatttttg cttgcagcat gatgctgact agcacacgaa gatga                     3525


<210>  8
<211>  1174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vector construct

<400>  8

Met Ala Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn 
1               5                   10                  15      


Val Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro 
            20                  25                  30          


Ser Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr 
        35                  40                  45              


Asp Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Ser Val 
    50                  55                  60                  


Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr Cys Ser Tyr 
65                  70                  75                  80  


Cys His His Thr Glu Pro Cys Phe Ser Pro Val Lys Ile Glu Gln Val 
                85                  90                  95      


Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr Ser Ala Gln 
            100                 105                 110         


Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys Tyr Arg Tyr 
        115                 120                 125             


Met Ala Ala Ala Ala Val Thr Gly Gly Gly Gly Ser Leu Gly Val Thr 
    130                 135                 140                 


Ser Ser Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Ala Ser Ala Glu Ala Gly Ile Thr Gly Thr 
                165                 170                 175     


Trp Tyr Asn Gln His Gly Ser Thr Phe Thr Val Thr Ala Gly Ala Asp 
            180                 185                 190         


Gly Asn Leu Thr Gly Gln Tyr Glu Asn Arg Ala Gln Gly Thr Gly Cys 
        195                 200                 205             


Gln Asn Ser Pro Tyr Thr Leu Thr Gly Arg Tyr Asn Gly Thr Lys Leu 
    210                 215                 220                 


Glu Trp Arg Val Glu Trp Asn Asn Ser Thr Glu Asn Cys His Ser Arg 
225                 230                 235                 240 


Thr Glu Trp Arg Gly Gln Tyr Gln Gly Gly Ala Glu Ala Arg Ile Asn 
                245                 250                 255     


Thr Gln Trp Asn Leu Thr Tyr Glu Gly Gly Ser Gly Pro Ala Thr Glu 
            260                 265                 270         


Gln Gly Gln Asp Thr Phe Thr Lys Val Lys Ile Asp Ala Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser Ser Gly Ser Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Leu Val Thr Gly Gly Gly Gly Ser Val Thr Thr Val Lys Glu Gly Thr 
                325                 330                 335     


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
            340                 345                 350         


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
        355                 360                 365             


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
    370                 375                 380                 


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
385                 390                 395                 400 


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Ala 
                405                 410                 415     


Ala Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Gly Pro His Ala 
            420                 425                 430         


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
        435                 440                 445             


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
    450                 455                 460                 


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
465                 470                 475                 480 


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
                485                 490                 495     


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Val Gln Gly Lys Leu 
            500                 505                 510         


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
        515                 520                 525             


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
    530                 535                 540                 


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
545                 550                 555                 560 


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
                565                 570                 575     


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
            580                 585                 590         


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
        595                 600                 605             


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
    610                 615                 620                 


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
625                 630                 635                 640 


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
                645                 650                 655     


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
            660                 665                 670         


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
        675                 680                 685             


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
    690                 695                 700                 


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
705                 710                 715                 720 


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
                725                 730                 735     


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
            740                 745                 750         


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
        755                 760                 765             


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
    770                 775                 780                 


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
785                 790                 795                 800 


Leu Glu Cys Gln Pro Ala Ala His Ala Gly Tyr Thr Cys Lys Val Phe 
                805                 810                 815     


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
            820                 825                 830         


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
        835                 840                 845             


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
    850                 855                 860                 


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
865                 870                 875                 880 


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
                885                 890                 895     


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
            900                 905                 910         


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
        915                 920                 925             


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
    930                 935                 940                 


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
945                 950                 955                 960 


Ser Gly Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
                965                 970                 975     


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
            980                 985                 990         


Gly Cys Lys Ile Ala Val Asn Pro  Leu Arg Ala Val Asp  Cys Ser Tyr 
        995                 1000                 1005             


Gly Asn  Ile Pro Ile Ser Ile  Asp Ile Pro Asn Ala  Ala Phe Ile 
    1010                 1015                 1020             


Arg Thr  Ser Asp Ala Pro Leu  Val Ser Thr Val Lys  Cys Glu Val 
    1025                 1030                 1035             


Ser Glu  Cys Thr Tyr Ser Ala  Asp Phe Gly Gly Met  Ala Thr Leu 
    1040                 1045                 1050             


Gln Tyr  Val Ser Asp Arg Glu  Gly Gln Cys Pro Val  His Ser His 
    1055                 1060                 1065             


Ser Ser  Thr Ala Thr Leu Gln  Glu Ser Thr Val His  Val Leu Glu 
    1070                 1075                 1080             


Lys Gly  Ala Val Thr Val His  Phe Ser Thr Ala Ser  Pro Gln Ala 
    1085                 1090                 1095             


Asn Phe  Ile Val Ser Leu Cys  Gly Lys Lys Thr Thr  Cys Asn Ala 
    1100                 1105                 1110             


Glu Cys  Lys Pro Pro Ala Asp  His Ile Val Ser Thr  Pro His Lys 
    1115                 1120                 1125             


Asn Asp  Gln Glu Phe Gln Ala  Ala Ile Ser Lys Thr  Ser Trp Ser 
    1130                 1135                 1140             


Trp Leu  Phe Ala Leu Phe Gly  Gly Ala Ser Ser Leu  Leu Ile Ile 
    1145                 1150                 1155             


Gly Leu  Met Ile Phe Ala Cys  Ser Met Met Leu Thr  Ser Thr Arg 
    1160                 1165                 1170             


Arg 
    


