
                                SEQUENCE LISTING

<110> Imaginab, Inc.
      Wilson, Ian Andrew
      Behera, Deepak
      Le, William Huy

<120> ANTIGEN-BINDING CONSTRUCTS AND METHODS OF USE THEREOF 

<130> IGNAB.047WO

<150> 62/826606
<151> 2019-03-29  

<150> 62/738938        
<151> 2018-09-28  

<160> 147

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 118
<212> PRT
<213> Murine

<400> 1
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met His Leu Cys Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser
        115             


<210> 2
<211> 120
<212> PRT
<213> Homo sapiens

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 3
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 4
<211> 118
<212> PRT
<213> Murine

<400> 4
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met His Leu Cys Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser
        115             


<210> 5
<211> 115
<212> PRT
<213> Homo sapiens

<400> 5
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Ala Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 6
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 6
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 7
<211> 107
<212> PRT
<213> Murine

<400> 7
Asp Val Gln Ile Asn Gln Ser Pro Ser Phe Leu Ala Ala Ser Pro Gly
 1               5                  10                  15      
Glu Thr Ile Thr Ile Asn Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 8
<211> 107
<212> PRT
<213> Homo sapiens

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 9
Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 10
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 10
atggagaccg atacactgct gctgtgggtg ctgctgctct gggtccctgg cagcacagga 60
gacatccaga tgacacagag ccctagctcc ctgagcgctt ccgtgggaga tagggtgacc 120
atcacatgcc ggacctccag gtccatctcc cagtacctgg cctggtacca gcagaagccc 180
ggcaaggtgc ccaagctgct catctatagc ggcagcaccc tgcagagcgg agtgccttcc 240
cggttttccg gatccggctc cggcacagac tttaccctga ccatctccag cctgcagcct 300
gaggatgtcg ccacctacta ctgccaacag cacaacgaga accccctgac cttcggcggc 360
ggaaccaagg tcgagatcaa gggaggaggc tccggaggag gaggccaagt gcagctggtc 420
caatccggcg ccgaagtgaa aaagcccggc gccaccgtga agatcagctg caaggtgtcc 480
ggcttcaaca tcaaggacac ctatatccac tgggtccagc aagcccccgg aaaaggcctg 540
gagtggatgg gacggattga ccccgccaac gacaacacac tctatgcctc caagttccag 600
ggcagggtga caatcaccgc cgacaccagc accgacacag cttatatgga gctgtcctcc 660
ctccggtccg aggataccgc cgtctactac tgcgccaggg gctacggcta ctacgtgttt 720
gaccactggg gccagggcac cctggtgaca gtgtccagcg gaggctgc              768

<210> 11
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 11
atggagaccg acaccctgct gctctgggtc ctcctgctgt gggtgcctgg cagcacagga 60
caggtgcaac tggtgcagag cggcgccgag gtcaagaaac ctggcgccac cgtgaagatc 120
agctgcaagg tgtccggctt caacatcaag gacacctaca tccactgggt ccaacaagcc 180
cccggaaagg gcctggaatg gatgggccgg attgaccccg ccaacgacaa caccctctat 240
gccagcaagt tccagggcag ggtcaccatc accgccgaca ccagcaccga caccgcctac 300
atggagctga gcagcctgcg gagcgaagac accgccgtgt actactgcgc caggggctac 360
ggctactacg tcttcgacca ttggggacag ggcaccctcg tgacagtgtc cagcggagga 420
ggatccggcg gaggaggaga tatccagatg acccagagcc cttccagcct gtccgcttcc 480
gtgggagatc gggtgaccat cacatgcagg acctccaggt ccatctccca gtacctggcc 540
tggtaccaac agaagcccgg caaggtgccc aagctgctga tctacagcgg cagcacactg 600
caatccggcg tcccttcccg gttttccgga tccggatccg gcaccgactt caccctgacc 660
atcagctccc tgcaacccga ggacgtggcc acctactact gtcagcagca caacgagaac 720
cccctcacct ttggcggcgg aaccaaggtc gagatcaagg gcggctgc              768

<210> 12
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 12
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ser
        115                 120                 125             
Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
    130                 135                 140                 
Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn
145                 150                 155                 160 
Ile Lys Asp Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly
                165                 170                 175     
Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr
            180                 185                 190         
Ala Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
        195                 200                 205             
Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
    210                 215                 220                 
Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp
225                 230                 235                 240 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
                245                 250             


<210> 13
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 13
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn
        35                  40                  45              
Ile Lys Asp Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr
65                  70                  75                  80  
Ala Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
                85                  90                  95      
Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Asp
    130                 135                 140                 
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
145                 150                 155                 160 
Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr Leu
                165                 170                 175     
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr
            180                 185                 190         
Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
        195                 200                 205             
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
    210                 215                 220                 
Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu Thr
225                 230                 235                 240 
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Cys
                245                 250             


<210> 14
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 14
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala
    130                 135                 140                 
Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser
145                 150                 155                 160 
Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Gln Gln Ala Pro
                165                 170                 175     
Gly Lys Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asn Asp Asn
            180                 185                 190         
Thr Leu Tyr Ala Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp
        195                 200                 205             
Thr Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu
    210                 215                 220                 
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe
225                 230                 235                 240 
Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
                245                 250                 255     


<210> 15
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 15
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn
        35                  40                  45              
Ile Lys Asp Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr
65                  70                  75                  80  
Ala Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
                85                  90                  95      
Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
145                 150                 155                 160 
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser
                165                 170                 175     
Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu
            180                 185                 190         
Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe
        195                 200                 205             
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
    210                 215                 220                 
Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn
225                 230                 235                 240 
Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Cys
                245                 250                 255     


<210> 16
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 16
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Asn Gln Ser Pro Ser Phe Leu Ala
            20                  25                  30          
Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Gly Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly
145                 150                 155                 160 
Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala
    210                 215                 220                 
Tyr Met His Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Thr Leu Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 17
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 17
atggagacag acaccctgct cctgtgggtg ctgctcctct gggtccctgg atccaccggc 60
gatgtccaga tcaaccaaag ccccagcttt ctggctgcct cccctggaga gacaatcacc 120
atcaattgcc ggaccagccg gagcatttcc cagtacctcg cctggtacca ggaaaagcct 180
ggcaagacca acaagctgct gatctactcc ggctccacac tccagagcgg cattccctcc 240
aggtttagcg gatccggatc cggaaccgac ttcacactca ccatctccgg cctggagccc 300
gaggacttcg ccatgtatta ttgccagcag cacaatgaga accccctgac cttcggcgct 360
ggcaccaagc tggagctgaa aggctccacc agcggaggcg gatccggagg aggaagcggc 420
ggcggaggct cctccgaagt gcagctgcaa cagagcggcg ccgaactggt gaagcctgga 480
gcttccgtga aactcagctg taccgccagc ggcttcaaca tcaaggatac ctacatccac 540
ttcgtgcggc aaaggcctga gcagggcctg gaatggatcg gcaggatcga ccccgccaac 600
gacaacaccc tctacgcctc caagttccaa ggcaaggcca caatcaccgc tgatacaagc 660
tccaacaccg cctacatgca cctcagctcc ctgaccagcg gagacaccgc cgtgtactac 720
tgcggacggg gatacggcta ctatgtgttc gaccactggg gccaaggcac cacactcacc 780
gtgtcctccg agcccaagtc ctgcgacaag acacacacct gtcccccttg tggaggagga 840
tcctccggag gcggctccgg cggacagcct agggagcccc aggtgtacac actgccccct 900
tccagggacg aactcaccaa gaaccaggtg tccctgacct gcctggtgaa gggattctac 960
cccagcgaca tcgccgtgga gtgggagtcc aacggccaac ccgagaacaa ttacaagacc 1020
accccccctg tgctcgattc cgacggctcc ttcttcctgt actccaagct caccgtggac 1080
aagtcccggt ggcaacaggg caatgtgttc tcctgcagcg tcatgcacga ggccctgcat 1140
aaccactaca cccagaaatc cctcagcctc tcccctggaa aatga                 1185

<210> 18
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 18
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val
            20                  25                  30          
Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
        35                  40                  45              
Ile Lys Asp Thr Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr
65                  70                  75                  80  
Ala Ser Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser
                85                  90                  95      
Asn Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp
        115                 120                 125             
Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Ser Thr Ser Gly Gly
    130                 135                 140                 
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Val Gln Ile
145                 150                 155                 160 
Asn Gln Ser Pro Ser Phe Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr
                165                 170                 175     
Ile Asn Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr Leu Ala Trp Tyr
            180                 185                 190         
Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly Ser
        195                 200                 205             
Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu Pro Glu Asp Phe Ala
225                 230                 235                 240 
Met Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu Thr Phe Gly Ala
                245                 250                 255     
Gly Thr Lys Leu Glu Leu Lys Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 19
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 19
atggagaccg acacactcct gctctgggtg ctcctgctgt gggtgcctgg cagcacagga 60
gaagtgcagc tgcagcagtc cggcgccgaa ctcgtcaaac ccggagcctc cgtcaaactg 120
tcctgcacag ccagcggctt caacatcaag gacacctaca tccatttcgt gcggcaaagg 180
cctgaacagg gactcgagtg gatcggcagg atcgaccccg ccaacgacaa taccctctac 240
gcctccaagt tccagggaaa ggccaccatt accgccgaca catccagcaa caccgcctac 300
atgcacctca gctccctgac atccggcgac accgccgtgt actactgcgg caggggctac 360
ggctactacg tgtttgacca ctggggccag ggaacaaccc tgaccgtgtc cagcggctcc 420
acctccggag gcggaagcgg cggaggatcc ggaggaggag gctcctccga cgtgcaaatc 480
aaccagtccc ctagcttcct ggccgctagc cctggcgaga caatcacaat caattgtcgg 540
accagccggt ccatctccca gtatctggcc tggtaccagg agaagcccgg caagacaaac 600
aagctgctca tctacagcgg cagcaccctc caatccggca tcccttcccg gtttagcggc 660
tccggatccg gaaccgactt taccctgacc atcagcggcc tggaacccga ggatttcgcc 720
atgtactact gccagcagca caacgagaat cccctgacct ttggagccgg cacaaagctc 780
gagctgaagg agcccaagag ctgcgacaaa acccacacct gtcccccttg cggaggagga 840
tcctccggcg gcggaagcgg aggacaaccc agggagcccc aggtctacac cctgcctcct 900
agccgggacg aactgacaaa gaaccaggtg tccctgacct gtctcgtcaa gggcttctac 960
ccttccgaca tcgccgtcga gtgggaaagc aacggccagc ccgagaacaa ttacaagacc 1020
acaccccccg tcctggacag cgatggcagc ttcttcctct actccaagct gaccgtggac 1080
aagagccggt ggcaacaagg caacgtgttc tcctgcagcg tcatgcatga ggccctgcac 1140
aatcactaca cccagaagag cctgagcctc tcccccggca agtga                 1185

<210> 20
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 20
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
145                 150                 155                 160 
Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Met Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala
    210                 215                 220                 
Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 21
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 21
atggagacag acaccctcct gctgtgggtc ctgctgctgt gggtgcctgg cagcacagga 60
gacatccaaa tgacccagtc ccctagcagc ctcagcgctt ccgtcggaga cagggtcacc 120
atcacatgca ggacctccag gtccatcagc cagtatctgg cctggtatca gcagaaaccc 180
ggcaaggtgc ctaagctgct gatctacagc ggcagcacac tccagagcgg agtgcccagc 240
cggttttccg gaagcggatc cggaaccgac ttcaccctga ccatttccag cctgcaacct 300
gaagacgtgg ccacctacta ctgtcagcag cacaacgaga accccctcac cttcggcgga 360
ggcaccaaag tcgagatcaa gggcagcacc agcggaggag gaagcggcgg aggctccgga 420
ggaggaggct cctcccaagt gcagctcgtc caaagcggcg ctgaggtgaa aaagcccggc 480
gccacagtca aaatctcctg caaggtcagc ggcttcaaca tcaaggatac ctacatccac 540
tgggtgcaac aggcccccgg caaaggactc gaatggatgg gccggatcga ccctgctaac 600
gacaacacac tctacgcctc caagttccag ggcagggtga ccatcaccgc cgatacctcc 660
accgacacag cctacatgga gctgagcagc ctgaggtccg aggacaccgc cgtctattac 720
tgcgcccggg gatacggcta ctacgtgttt gaccattggg gacagggaac actcgtgacc 780
gtgagctccg agcccaagag ctgcgacaag acccacacat gtcctccttg cggaggaggc 840
agctccggag gcggatccgg cggacaacct agggagcccc aggtctatac cctgcccccc 900
agcagggacg agctgacaaa gaaccaggtc tccctgacct gcctggtgaa aggattctac 960
cccagcgaca tcgctgtcga atgggagtcc aacggccagc ccgagaacaa ctacaagaca 1020
accccccccg tgctggattc cgacggcagc ttcttcctct actccaagct gaccgtcgac 1080
aagtccaggt ggcagcaggg caacgtgttt tcctgctccg tgatgcatga ggccctgcac 1140
aaccactaca cccagaagtc cctgagcctc agccctggca agtga                 1185

<210> 22
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 22
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn
        35                  40                  45              
Ile Lys Asp Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr
65                  70                  75                  80  
Ala Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
                85                  90                  95      
Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly
    130                 135                 140                 
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Ile Gln Met
145                 150                 155                 160 
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                165                 170                 175     
Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr Leu Ala Trp Tyr
            180                 185                 190         
Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Ser Gly Ser
        195                 200                 205             
Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala
225                 230                 235                 240 
Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu Thr Phe Gly Gly
                245                 250                 255     
Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 23
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 23
atggagaccg atacactgct gctctgggtg ctgctgctgt gggtgcctgg aagcaccgga 60
caggtgcaac tggtccagtc cggcgccgag gtgaaaaagc ctggcgccac cgtcaagatc 120
tcctgtaagg tgagcggctt caacatcaag gacacctaca tccactgggt gcagcaggct 180
cccggaaagg gactggagtg gatgggcagg atcgaccctg ccaatgacaa caccctctac 240
gccagcaagt tccaaggacg ggtgaccatc acagccgaca catccaccga cacagcctat 300
atggagctct ccagcctgag gtccgaggac accgccgtgt actactgtgc caggggatac 360
ggctattacg tgttcgacca ctggggacag ggcaccctgg tgaccgtgag cagcggaagc 420
accagcggcg gaggcagcgg aggcggaagc ggcggcggcg gatcctccga cattcagatg 480
acccaatccc cctccagcct gtccgctagc gtgggagaca gggtgacaat cacatgtcgg 540
acctccaggt ccatcagcca atatctcgcc tggtatcagc agaagcccgg caaggtgccc 600
aagctcctga tctacagcgg ctccaccctc caaagcggag tgccttcccg gtttagcgga 660
agcggcagcg gcacagactt taccctgaca atcagctccc tgcaacctga ggacgtcgcc 720
acatactact gccagcagca caacgagaac cctctcacct ttggcggcgg caccaaagtg 780
gagatcaagg agcccaaatc ctgcgacaag acacacacct gccccccttg tggaggaggc 840
agctccggcg gcggcagcgg cggacaaccc cgggaacctc aggtgtatac actcccccct 900
tccagggatg agctgaccaa gaaccaagtc tccctgacct gtctggtgaa aggcttctac 960
ccctccgaca tcgctgtcga gtgggagagc aacggccagc ccgaaaacaa ctataagacc 1020
accccccccg tgctcgattc cgatggcagc ttcttcctgt actccaagct cacagtcgac 1080
aagagccggt ggcaacaggg caacgtcttc tcctgtagcg tcatgcacga ggccctccac 1140
aaccactaca cccagaagtc cctctccctg agccccggaa aatga                 1185

<210> 24
<211> 235
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr
            20                  25                  30          
Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser
        35                  40                  45              
Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala
    50                  55                  60                  
Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala
65                  70                  75                  80  
Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp
                85                  90                  95      
Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr
            100                 105                 110         
Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe
        115                 120                 125             
Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
    130                 135                 140                 
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
145                 150                 155                 160 
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
                165                 170                 175     
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
            180                 185                 190         
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
        195                 200                 205             
Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser
    210                 215                 220                 
Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val
225                 230                 235 


<210> 25
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 25
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60


<210> 26
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 26
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly
            20  


<210> 27
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 27
agtggtggag gaggc                                                  15

<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 28
Ser Gly Gly Gly Gly
 1               5  


<210> 29
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 29
ggcggaggga gtggcggagg cggc                                        24

<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 30
Gly Gly Gly Ser Gly Gly Gly Gly
 1               5              


<210> 31
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 31
ggcggctgc                                                         9

<210> 32
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 32
Gly Gly Cys
 1          


<210> 33
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 33
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60


<210> 34
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 34
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly
            20  


<210> 35
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 35
ggctccacat ccggcggagg ctctggcggt ggatctggcg gaggcggctc atcc       54

<210> 36
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 36
Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15      
Ser Ser
        


<210> 37
<211> 393
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 37
gagcctaagt cctgcgacaa gacccacacc tgtccccctt gcggcggagg aagcagcgga 60
ggcggatccg gtggccagcc tcgggagcct caggtgtaca ccctgcctcc ctcccgggac 120
gagctgacca agaaccaggt gtccctgacc tgtctggtca agggcttcta cccttccgat 180
atcgccgtgg agtgggagtc caacggccag cctgagaaca actacaagac cacccctcct 240
gtgctggact ccgacggctc cttcttcctg tactccaagc tcacagtgga taagtcccgg 300
tggcagcagg gcaacgtgtt ctcctgctcc gtgatgcacg aggccctgca caaccactat 360
acccagaagt ccctgtccct gtctcctggc aag                              393

<210> 38
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 38
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly
 1               5                  10                  15      
Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val
            20                  25                  30          
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        35                  40                  45              
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    50                  55                  60                  
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
65                  70                  75                  80  
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                85                  90                  95      
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            100                 105                 110         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        115                 120                 125             
Pro Gly Lys
    130     


<210> 39
<211> 321
<212> DNA
<213> Murine

<400> 39
gatgtccaga taaaccagtc tccatctttt cttgctgcgt ctcctggaga aaccattact 60
ataaattgca ggacaagtag gagtattagt caatatttag cctggtatca agagaaacct 120
gggaaaacta ataagcttct tatctactct ggatccactc tgcaatctgg aattccatca 180
aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtgg cctggagcct 240
gaagattttg caatgtatta ctgtcaacag cataatgaaa acccgctcac gttcggtgct 300
gggaccaagc tggagctgaa g                                           321

<210> 40
<211> 107
<212> PRT
<213> Murine

<400> 40
Asp Val Gln Ile Asn Gln Ser Pro Ser Phe Leu Ala Ala Ser Pro Gly
 1               5                  10                  15      
Glu Thr Ile Thr Ile Asn Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 41
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 41
gacgtccaga taacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca ggacaagtag gagtattagt caatatttag cctggtatca gcagaaacca 120
gggaaagttc ctaagctcct gatctattct ggatccactc tgcaatctgg agtcccatct 180
cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagatgttg caacttatta ctgtcaacag cataatgaaa acccgctcac gttcggcgga 300
gggaccaagg tggagatcaa a                                           321

<210> 42
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 42
Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 43
<211> 354
<212> DNA
<213> Murine

<400> 43
gaggtccagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg 60
tcctgcacag cttctggctt caacattaaa gacacctata tacacttcgt gaggcagagg 120
cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatgataa tactttatat 180
gcctcaaagt tccagggcaa ggccactata acagcagaca catcatccaa cacagcctac 240
atgcacctct gcagcctgac atctggggac actgccgtct attactgtgg tagaggttat 300
ggttactacg tatttgacca ctggggccaa ggcaccactc tcacagtctc ctca       354

<210> 44
<211> 118
<212> PRT
<213> Murine

<400> 44
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met His Leu Cys Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser
        115             


<210> 45
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 45
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg 60
agctgcgcgg cgagcggctt taacattaaa gatacctata ttcattttgt gcgccaggcg 120
ccgggcaaag gcctggaatg gattggccgc attgatccgg cgaacgataa caccctgtat 180
gcgagcaaat ttcagggcaa agcgaccatt agcgcggata ccagcaaaaa caccgcgtat 240
ctgcagatga acagcctgcg cgcgggagat accgcggtgt attattgcgg ccgcggctat 300
ggctattatg tgtttgatca ttggggccag ggcaccctgg tgaccgtgag cagc       354

<210> 46
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 47
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 47
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg 60
agctgcgcgg cgagcggctt taacattaaa gatacctata ttcattttgt gcgccaggcg 120
ccgggcaaag gcctggaatg gattggccgc attgatccgg cgaacgataa caccctgtat 180
gcgagcaaat ttcagggcaa agcgaccatt agcgcggata ccagcaaaaa caccgcgtat 240
ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgg ccgcggctat 300
ggctattatg tgtttgatca ttggggccag ggcaccctgg tgaccgtgag cagc       354

<210> 48
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 49
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 49
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgac cgtgaaaatt 60
agctgcaaag tgagcggctt taacattaaa gatacctata ttcattttgt gcagcaggcg 120
ccgggcaaag gcctggaatg gattggccgc attgatccgg cgaacgataa caccctgtat 180
gcgagcaaat ttcagggcaa agcgaccatt accgcggata ccagcaccga taccgcgtat 240
atggaactga gcagcctgcg cagcggagat accgcggtgt attattgcgg ccgcggctat 300
ggctattatg tgtttgatca ttggggccag ggcaccctgg tgaccgtgag cagc       354

<210> 50
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 50
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Gly Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 51
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 51
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgac cgtgaaaatt 60
agctgcaaag tgagcggctt taacattaaa gatacctata ttcattttgt gcagcaggcg 120
ccgggcaaag gcctggaatg gattggccgc attgatccgg cgaacgataa caccctgtat 180
gcgagcaaat ttcagggcaa agcgaccatt accgcggata ccagcaccga taccgcgtat 240
atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgg ccgcggctat 300
ggctattatg tgtttgatca ttggggccag ggcaccctgg tgaccgtgag cagc       354

<210> 52
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 52
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser
        115         


<210> 53
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 53
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro
            20              


<210> 54
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 54
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Gly
 1               5                  10                  15      
Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25  


<210> 55
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 55
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro
            


<210> 56
<211> 70
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 56
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys
 1               5                  10                  15      
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro
            20                  25                  30          
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu
        35                  40                  45              
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro
    50                  55                  60                  
Glu Leu Leu Gly Gly Pro
65                  70  


<210> 57
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 57
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys
 1               5                  10                  15      
Pro Ala Pro Glu Leu Leu Gly Gly Pro
            20                  25  


<210> 58
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 58
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro
            20              


<210> 59
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 59
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro
            20  


<210> 60
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 60
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro
            20  


<210> 61
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 61
tctagagccg ccacc                                                  15

<210> 62
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 62
tctagagccg ccacc                                                  15

<210> 63
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 63
aagctt                                                            6

<210> 64
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 64
aagctt                                                            6

<210> 65
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 65
tctagagccg ccacc                                                  15

<210> 66
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 66
aagctt                                                            6

<210> 67
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 67
tctagagccg ccacc                                                  15

<210> 68
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 68
aagctt                                                            6

<210> 69
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 69
tctagagccg ccacc                                                  15

<210> 70
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 70
aagctt                                                            6

<210> 71
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 71
tctagagccg ccacc                                                  15

<210> 72
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 72
aagctt                                                            6

<210> 73
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 73
tctagagccg ccacc                                                  15

<210> 74
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 74
aagctt                                                            6

<210> 75
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 75
tctagagccg ccacc                                                  15

<210> 76
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Restriction site

<400> 76
aagctt                                                            6

<210> 77
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 77
atggagaccg atacactgct gctgtgggtg ctgctgctct gggtccctgg cagcacagga 60
gacatccaga tgacacagag ccctagctcc ctgagcgctt ccgtgggaga tagggtgacc 120
atcacatgcc ggacctccag gtccatctcc cagtacctgg cctggtacca gcagaagccc 180
ggcaaggtgc ccaagctgct catctatagc ggcagcaccc tgcagagcgg agtgccttcc 240
cggttttccg gatccggctc cggcacagac tttaccctga ccatctccag cctgcagcct 300
gaggatgtcg ccacctacta ctgccaacag cacaacgaga accccctgac cttcggcggc 360
ggaaccaagg tcgagatcaa gtccggagga ggaggccaag tgcagctggt ccaatccggc 420
gccgaagtga aaaagcccgg cgccaccgtg aagatcagct gcaaggtgtc cggcttcaac 480
atcaaggaca cctatatcca ctgggtccag caagcccccg gaaaaggcct ggagtggatg 540
ggacggattg accccgccaa cgacaacaca ctctatgcct ccaagttcca gggcagggtg 600
acaatcaccg ccgacaccag caccgacaca gcttatatgg agctgtcctc cctccggtcc 660
gaggataccg ccgtctacta ctgcgccagg ggctacggct actacgtgtt tgaccactgg 720
ggccagggca ccctggtgac agtgtccagc ggaggctgc                        759

<210> 78
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 78
atggagaccg acaccctgct gctctgggtc ctcctgctgt gggtgcctgg cagcacagga 60
caggtgcaac tggtgcagag cggcgccgag gtcaagaaac ctggcgccac cgtgaagatc 120
agctgcaagg tgtccggctt caacatcaag gacacctaca tccactgggt ccaacaagcc 180
cccggaaagg gcctggaatg gatgggccgg attgaccccg ccaacgacaa caccctctat 240
gccagcaagt tccagggcag ggtcaccatc accgccgaca ccagcaccga caccgcctac 300
atggagctga gcagcctgcg gagcgaagac accgccgtgt actactgcgc caggggctac 360
ggctactacg tcttcgacca ttggggacag ggcaccctcg tgacagtgtc cagctccggc 420
ggaggaggag atatccagat gacccagagc ccttccagcc tgtccgcttc cgtgggagat 480
cgggtgacca tcacatgcag gacctccagg tccatctccc agtacctggc ctggtaccaa 540
cagaagcccg gcaaggtgcc caagctgctg atctacagcg gcagcacact gcaatccggc 600
gtcccttccc ggttttccgg atccggatcc ggcaccgact tcaccctgac catcagctcc 660
ctgcaacccg aggacgtggc cacctactac tgtcagcagc acaacgagaa ccccctcacc 720
tttggcggcg gaaccaaggt cgagatcaag ggcggctgc                        759

<210> 79
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 79
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Gly Gly Gly Ser
 1               5                  10                  15      
Ser Gly Gly Gly Ser Gly
            20          


<210> 80
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 80
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 81
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 81
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
 1               5                  10                  15      
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 82
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M variable light sequence

<400> 82
Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 83
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker sequence

<400> 83
Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15      
Ser Ser


<210> 84
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M variable heavy sequence

<400> 84
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 85
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 EH1

<400> 85
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Gly Gly Gly Ser
 1               5                  10                  15      
Ser Gly Gly Gly Ser Gly
            20          


<210> 86
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 86
Glu Arg Lys
 1          


<210> 87
<211> 9
<212> PRT
<213> Homo sapiens

<400> 87
Cys Cys Val Glu Cys Pro Pro Cys Pro
 1               5                  


<210> 88
<211> 10
<212> PRT
<213> Homo sapiens

<400> 88
Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
 1               5                  10  


<210> 89
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 CH3

<400> 89
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 90
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 EH2

<400> 90
Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Gly Gly Gly Ser
 1               5                  10                  15      
Ser Gly Gly Gly Ser Gly
            20          


<210> 91
<211> 9
<212> PRT
<213> Homo sapiens

<400> 91
Ser Cys Val Glu Cys Pro Pro Cys Pro
 1               5                  


<210> 92
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH1

<400> 92
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly
 1               5                  10                  15      
Gly Ser Ser Gly Gly Gly Ser Gly
            20                  


<210> 93
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 93
Glu Pro Lys Ser Cys Asp Lys Thr His Thr
 1               5                  10  


<210> 94
<211> 4
<212> PRT
<213> Homo sapiens

<400> 94
Cys Pro Pro Cys
 1              


<210> 95
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 CH3 (G1m1 allotype)

<400> 95
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
 1               5                  10                  15      
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 96
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 CH3 (nG1m1 allotype)

<400> 96
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 97
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 NH1

<400> 97
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro


<210> 98
<211> 7
<212> PRT
<213> Homo sapiens

<400> 98
Ala Pro Pro Val Ala Gly Pro
 1               5          


<210> 99
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 NH2

<400> 99
Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro
              

<210> 100
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH3

<400> 100
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro
 1               5                  10                  15      
Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25          


<210> 101
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 101
Glu Pro Lys Ser Ser Asp Lys Thr His Thr
 1               5                  10  


<210> 102
<211> 7
<212> PRT
<213> Homo sapiens

<400> 102
Cys Pro Pro Cys Pro Pro Cys
 1               5          


<210> 103
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH5

<400> 103
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro
 1               5                  10                  15      
Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  30  


<210> 104
<211> 10
<212> PRT
<213> Homo sapiens

<400> 104
Cys Pro Pro Cys Pro Pro Cys Pro Pro Cys
 1               5                  10  


<210> 105
<211> 10
<212> PRT
<213> Homo sapiens

<400> 105
Cys Pro Pro Cys Val Glu Cys Pro Pro Cys
 1               5                  10  


<210> 106
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3/IgG1 EH6

<400> 106
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Val Glu Cys
 1               5                  10                  15      
Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  


<210> 107
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 107
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr
 1               5                  10          


<210> 108
<211> 7
<212> PRT
<213> Homo sapiens

<400> 108
Cys Val Glu Cys Pro Pro Cys
 1               5          


<210> 109
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3/IgG1 EH7

<400> 109
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15      
Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  


<210> 110
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3/IgG1 EH8

<400> 110
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15      
Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  30          


<210> 111
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH2

<400> 111
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly
 1               5                  10                  15      
Gly Ser Ser Gly Gly Gly Ser Gly
            20                  


<210> 112
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker sequence

<400> 112
Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser
 1               5                  10          


<210> 113
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker sequence

<400> 113
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 114
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker sequence

<400> 114
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10  


<210> 115
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker sequence

<400> 115
Gly Gly Gly Gly Ser
 1               5  


<210> 116
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 NH1

<400> 116
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro
            20              


<210> 117
<211> 23
<212> PRT
<213> Homo sapiens

<220> 
<223> Human IgG1 NH2

<400> 117
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro
            20              


<210> 118
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 NH3

<400> 118
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro
 1               5                  10                  15      
Cys Ala Pro Glu Leu Leu Gly Gly Pro
            20                  25  


<210> 119
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 NH4

<400> 119
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Val Glu
 1               5                  10                  15      
Cys Pro Pro Cys Ala Pro Glu Leu Leu Gly Gly Pro
            20                  25              


<210> 120
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH4

<400> 120
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Val Glu
 1               5                  10                  15      
Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  30  


<210> 121
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 NH5

<400> 121
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro
 1               5                  10                  15      
Cys Pro Pro Cys Ala Pro Glu Leu Leu Gly Gly Pro
            20                  25              


<210> 122
<211> 5
<212> PRT
<213> Homo sapiens

<400> 122
Cys Pro Pro Cys Pro
 1               5  


<210> 123
<211> 8
<212> PRT
<213> Homo sapiens

<400> 123
Ala Pro Glu Leu Leu Gly Gly Pro
 1               5              


<210> 124
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG4 NH

<400> 124
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro
            20  


<210> 125
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG4 EH

<400> 125
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Ser
 1               5                  10                  15      
Ser Gly Gly Gly Ser Gly
            20          


<210> 126
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 126
Glu Ser Lys Tyr Gly Pro Pro
 1               5          


<210> 127
<211> 8
<212> PRT
<213> Homo sapiens

<400> 127
Ala Pro Glu Phe Leu Gly Gly Pro
 1               5              


<210> 128
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG3 CH3

<400> 128
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 129
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG4 CH3

<400> 129
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            100                 105         


<210> 130
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH1(Minibody 1)

<400> 130
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 131
<211> 396
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH3(Minibody 1)

<400> 131
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly
        275                 280                 285             
Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
    290                 295                 300                 
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
305                 310                 315                 320 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
                325                 330                 335     
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
            340                 345                 350         
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
        355                 360                 365             
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
    370                 375                 380                 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
385                 390                 395     


<210> 132
<211> 1191
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH3(M1)

<400> 132
atggagaccg ataccctgct gctgtgggtg ctgctgctgt gggtgcccgg ctccacaggc 60
gatgtgcaga tcacacagag ccctagcagc ctgagcgcca gcgtgggaga tagagtcacc 120
atcacatgca ggaccagcag aagcattagc cagtacctgg cctggtacca gcaaaagccc 180
ggcaaggtgc ccaagctgct gatctacagc ggctccaccc tgcagagcgg cgtgcccagc 240
agattctccg gctccggaag cggcacagac tttaccctga ccatctcctc cctgcagccc 300
gaggatgtcg ccacctacta ctgccagcag cacaacgaaa accccctgac atttggcggc 360
ggcaccaagg tggagatcaa gggcagcacc agcggtggag gaagtggagg tggaagtgga 420
ggaggcggaa gcagcgaggt gcagctggtg gagagtggtg gaggactggt gcagcccgga 480
ggcagcctga gactgagctg tgctgcctcc ggattcaata tcaaggacac ctacatccac 540
ttcgtgagac aggcccccgg caagggactg gagtggattg gaaggatcga ccccgccaac 600
gacaacaccc tgtacgccag caaattccag ggcaaggcca caatcagcgc cgacaccagc 660
aagaacaccg cctatctgca gatgaactcc ctgagagccg aggacacagc cgtgtactac 720
tgcggcaggg gctacggcta ttacgtgttc gaccactggg gccagggcac cctggtgaca 780
gtgagcagcg aacccaagag ctccgacaag acccacacct gtcccccttg ccctccttgt 840
ggcggaggaa gctccggagg cggaagcgga ggacagccta gggagcccca ggtgtatacc 900
ctccccccct ccagggaaga gatgaccaag aaccaggtga gcctgacctg cctcgtgaag 960
ggcttttatc cctccgatat cgccgtggag tgggagagca acggccagcc tgagaacaat 1020
tacaagacca ccccccctgt gctggactcc gatggcagct tcttcctgta ttccaagctg 1080
accgtcgaca agtccaggtg gcaacagggc aacgtcttca gctgcagcgt gatgcacgag 1140
gccctgcaca atcactacac ccagaagtcc ctctccctga gccccggctg a          1191


<210> 133
<211> 399
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH5(M1)

<400> 133
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser
        275                 280                 285             
Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
    290                 295                 300                 
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
305                 310                 315                 320 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
                325                 330                 335     
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
            340                 345                 350         
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
        355                 360                 365             
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
    370                 375                 380                 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
385                 390                 395                 


<210> 134
<211> 235
<212> PRT
<213> Homo sapiens

<400> 134
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr
            20                  25                  30          
Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser
        35                  40                  45              
Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala
    50                  55                  60                  
Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala
65                  70                  75                  80  
Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp
                85                  90                  95      
Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr
            100                 105                 110         
Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe
        115                 120                 125             
Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
    130                 135                 140                 
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
145                 150                 155                 160 
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
                165                 170                 175     
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
            180                 185                 190         
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
        195                 200                 205             
Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser
    210                 215                 220                 
Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val
225                 230                 235 


<210> 135
<211> 210
<212> PRT
<213> Homo sapiens

<400> 135
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu
 1               5                  10                  15      
His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln
            20                  25                  30          
Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser
        35                  40                  45              
Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp
    50                  55                  60                  
Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile
65                  70                  75                  80  
His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala
                85                  90                  95      
Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly
            100                 105                 110         
Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys
        115                 120                 125             
Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro
    130                 135                 140                 
Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro
145                 150                 155                 160 
Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Val Thr Leu Gly Leu Leu
                165                 170                 175     
Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Met His
            180                 185                 190         
Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe
        195                 200                 205             
Tyr Lys
    210 


<210> 136
<211> 1200
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH5(M1)

<400> 136
atggagacag acaccctcct cctgtgggtg ctgctgctgt gggtgcccgg atccaccgga 60
gacgtgcaga tcacacagag ccccagctcc ctgtccgcta gcgtgggcga cagagtgacc 120
atcacctgca ggaccagcag gagcatctcc cagtacctcg cttggtacca gcagaagcct 180
ggcaaggtgc ccaagctgct gatttacagc ggatccaccc tgcagagcgg cgtgcctagc 240
aggtttagcg gcagcggatc cggaacagac ttcaccctga ccatcagcag cctgcagcct 300
gaagatgtgg ccacctacta ctgtcagcag cacaacgaaa accccctcac cttcggcggc 360
ggcacaaagg tggaaatcaa gggcagcacc tccggaggag gcagcggcgg aggcagcgga 420
ggcggcggct ccagcgaagt gcagctggtc gagagcggag gcggactggt gcaacccgga 480
ggaagcctga ggctgagctg tgccgccagc ggcttcaaca tcaaggacac atacattcac 540
tttgtgaggc aggctcctgg aaagggcctg gagtggatcg gcagaatcga ccccgctaac 600
gacaacaccc tgtacgccag caagttccag ggcaaggcca ccatctccgc cgacacaagc 660
aagaataccg cctacctgca gatgaactcc ctgagggccg aggataccgc cgtgtactac 720
tgcggcaggg gctatggcta ctacgtgttt gaccactggg gccagggcac actggtgaca 780
gtgagctccg agcccaagag ctccgacaag acacacacct gccctccttg ccccccttgt 840
cctccctgtg gaggaggaag cagcggagga ggaagcggcg gacagcccag agagcctcaa 900
gtgtataccc tgcccccctc cagggaagag atgaccaaga accaggtgag cctgacatgc 960
ctggtcaaag gcttctaccc cagcgatatt gctgtggagt gggagagcaa cggccagccc 1020
gagaacaact acaagaccac accccccgtc ctggatagcg atggcagctt cttcctgtac 1080
agcaagctga ccgtggacaa gtccaggtgg cagcagggca acgtcttctc ctgcagcgtg 1140
atgcacgagg ctctgcataa ccactacaca cagaagtccc tcagcctgag ccctggatga 1200


<210> 137
<211> 398
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH7(Minibody 1)

<400> 137
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr
            260                 265                 270         
Thr His Thr Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly
        275                 280                 285             
Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
    290                 295                 300                 
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
305                 310                 315                 320 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
                325                 330                 335     
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
            340                 345                 350         
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
        355                 360                 365             
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
    370                 375                 380                 
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
385                 390                 395             


<210> 138
<211> 1197
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH7(Minibody 1)

<400> 138
atggagacag acaccctcct cctgtgggtg ctgctgctgt gggtgcccgg atccaccgga 60
gacgtgcaga tcacacagag ccccagctcc ctgtccgcta gcgtgggcga cagagtgacc 120
atcacctgca ggaccagcag gagcatctcc cagtacctcg cttggtacca gcagaagcct 180
ggcaaggtgc ccaagctgct gatttacagc ggatccaccc tgcagagcgg cgtgcctagc 240
aggtttagcg gcagcggatc cggaacagac ttcaccctga ccatcagcag cctgcagcct 300
gaagatgtgg ccacctacta ctgtcagcag cacaacgaaa accccctcac cttcggcggc 360
ggcacaaagg tggaaatcaa gggcagcacc tccggaggag gcagcggcgg aggcagcgga 420
ggcggcggct ccagcgaagt gcagctggtc gagagcggag gcggactggt gcaacccgga 480
ggaagcctga ggctgagctg tgccgccagc ggcttcaaca tcaaggacac atacattcac 540
tttgtgaggc aggctcctgg aaagggcctg gagtggatcg gcagaatcga ccccgctaac 600
gacaacaccc tgtacgccag caagttccag ggcaaggcca ccatctccgc cgacacaagc 660
aagaataccg cctacctgca gatgaactcc ctgagggccg aggataccgc cgtgtactac 720
tgcggcaggg gctatggcta ctacgtgttt gaccactggg gccagggcac actggtgaca 780
gtgagctccg agctgaagac acctctgggc gacacaacac acacctgccc cccttgtcct 840
ccctgtggag gaggaagcag cggaggagga agcggcggac agcccagaga gcctcaagtg 900
tataccctgc ccccctccag ggaagagatg accaagaacc aggtgagcct gacatgcctg 960
gtcaaaggct tctaccccag cgatattgct gtggagtggg agagcaacgg ccagcccgag 1020
aacaactaca agaccacacc ccccgtcctg gatagcgatg gcagcttctt cctgtacagc 1080
aagctgaccg tggacaagtc caggtggcag cagggcaacg tcttctcctg cagcgtgatg 1140
cacgaggctc tgcataacca ctacacacag aagtccctca gcctgagccc tggatga    1197


<210> 139
<211> 401
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH8(Minibody 1)

<400> 139
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr
            260                 265                 270         
Thr His Thr Cys Pro Pro Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly
        275                 280                 285             
Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr
    290                 295                 300                 
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
305                 310                 315                 320 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
                325                 330                 335     
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
            340                 345                 350         
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
        355                 360                 365             
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
    370                 375                 380                 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
385                 390                 395                 400 
Gly
   

<210> 140
<211> 1206
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH8(Minibody 1)

<400> 140
atggagacag acaccctcct cctgtgggtg ctgctgctgt gggtgcccgg atccaccgga 60
gacgtgcaga tcacacagag ccccagctcc ctgtccgcta gcgtgggcga cagagtgacc 120
atcacctgca ggaccagcag gagcatctcc cagtacctcg cttggtacca gcagaagcct 180
ggcaaggtgc ccaagctgct gatttacagc ggatccaccc tgcagagcgg cgtgcctagc 240
aggtttagcg gcagcggatc cggaacagac ttcaccctga ccatcagcag cctgcagcct 300
gaagatgtgg ccacctacta ctgtcagcag cacaacgaaa accccctcac cttcggcggc 360
ggcacaaagg tggaaatcaa gggcagcacc tccggaggag gcagcggcgg aggcagcgga 420
ggcggcggct ccagcgaagt gcagctggtc gagagcggag gcggactggt gcaacccgga 480
ggaagcctga ggctgagctg tgccgccagc ggcttcaaca tcaaggacac atacattcac 540
tttgtgaggc aggctcctgg aaagggcctg gagtggatcg gcagaatcga ccccgctaac 600
gacaacaccc tgtacgccag caagttccag ggcaaggcca ccatctccgc cgacacaagc 660
aagaataccg cctacctgca gatgaactcc ctgagggccg aggataccgc cgtgtactac 720
tgcggcaggg gctatggcta ctacgtgttt gaccactggg gccagggcac actggtgaca 780
gtgagctccg agctgaagac acctctgggc gacacaacac acacctgccc tccttgcccc 840
ccttgtcctc cctgtggagg aggaagcagc ggaggaggaa gcggcggaca gcccagagag 900
cctcaagtgt ataccctgcc cccctccagg gaagagatga ccaagaacca ggtgagcctg 960
acatgcctgg tcaaaggctt ctaccccagc gatattgctg tggagtggga gagcaacggc 1020
cagcccgaga acaactacaa gaccacaccc cccgtcctgg atagcgatgg cagcttcttc 1080
ctgtacagca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt cttctcctgc 1140
agcgtgatgc acgaggctct gcataaccac tacacacaga agtccctcag cctgagccct 1200
ggatga                                                            1206


<210> 141
<211> 391
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 2 EH2(Minibody 1)

<400> 141
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Arg Lys Ser Cys Val Glu Cys Pro
            260                 265                 270         
Pro Cys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro
        275                 280                 285             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
    290                 295                 300                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
305                 310                 315                 320 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                325                 330                 335     
Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            340                 345                 350         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        355                 360                 365             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    370                 375                 380                 
Ser Leu Ser Leu Ser Pro Gly
385                 390     



<210> 142
<211> 1236
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 2 EH2(Minibody 1)

<400> 142
atggaaaccg acacactgct gctgtgggtg ctgctgctgt gggtccctgg ctccaccgga 60
gacgtccaga tcacacagag ccccagcagc ctgtccgcca gcgtgggaga cagggtgacc 120
gacgtccaga tcacacagag ccccagcagc ctgtccgcca gcgtgggaga cagggtgacc 180
gacgtccaga tcacacagag ccccagcagc ctgtccgcca gcgtgggaga cagggtgacc 240
ggcaaggtcc ccaaactgct gatctacagc ggctccaccc tgcagtccgg cgtgcctagc 300
aggttctccg gcagcggatc cggcaccgac ttcaccctga ccatcagctc cctgcagcct 360
gaggacgtgg ctacctacta ctgccaacag cacaacgaga accccctgac ctttggaggc 420
ggcaccaagg tggaaatcaa gggcagcacc agcggcggag gaagcggagg aggatccgga 480
ggaggcggaa gctccgaggt gcagctggtg gaaagcggcg gcggactggt gcagcctgga 540
ggaagcctca gactgagctg tgccgccagc ggattcaaca tcaaagacac ctacattcat 600
ttcgtgagac aggcccccgg caagggcctc gaatggatcg gaaggatcga ccccgctaac 660
gacaataccc tgtacgcctc caagttccag ggaaaggcca ccatctccgc cgatacctcc 720
aagaacaccg cctacctcca gatgaactcc ctgagggccg aagataccgc cgtctactac 780
tgtggcaggg gctacggcta ctatgtgttc gatcactggg gccaaggaac cctggtgacc 840
gtgagcagcg aaaggaagag ctgcgtggag tgtcctcctt gtcccggcgg cggctccagc 900
ggcggaggct ccggcggcca gcctagagaa cctcaggtgt acaccctccc cccctccaga 960
gaggagatga ccaagaacca ggtgtccctg acctgcctgg tgaaaggctt ctatcccagc 1020
gacatcgccg tggaatggga gtccaacggc cagcccgaga acaactacaa gaccacccct 1080
cccatgctgg attccgacgg cagctttttc ctgtacagca agctcaccgt ggacaagagc 1140
agatggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggctct gcataaccac 1200
tacacccaga agagcctgtc cctgtccccc ggatga                           1236


<210> 143
<211> 391
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 2 EH2(Minibody 1)(VH-K67R)

<400> 143
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Arg Lys Ser Cys Val Glu Cys Pro
            260                 265                 270         
Pro Cys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro
        275                 280                 285             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
    290                 295                 300                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
305                 310                 315                 320 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                325                 330                 335     
Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            340                 345                 350         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        355                 360                 365             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    370                 375                 380                 
Ser Leu Ser Leu Ser Pro Gly
385                 390     


<210> 144
<211> 1176
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 2 EH2(Minibody 1)

<400> 144
atggagaccg acaccctcct cctgtgggtg ctgctgctgt gggtgcctgg aagcaccggc 60
gatgtgcaga tcacccagag ccctagcagc ctgtccgctt ccgtgggcga cagggtgacc 120
atcacctgta ggacctccag gagcatctcc cagtacctgg cctggtacca gcagaagccc 180
ggcaaggtgc ccaaactgct catctactcc ggcagcacac tccagagcgg cgtccctagc 240
agattcagcg gaagcggcag cggcaccgac ttcaccctga ccatcagctc cctgcagccc 300
gaggacgtgg ccacctatta ctgtcagcag cacaacgaaa accccctgac cttcggcggc 360
ggcacaaaag tggagatcaa gggcagcacc agcggaggcg gatccggcgg cggcagcggc 420
ggcggaggat ccagcgaagt gcagctggtc gaaagcggag gcggactggt gcagcctgga 480
ggaagcctga gactcagctg cgccgcctcc ggattcaaca tcaaggacac ctacatccac 540
ttcgtgaggc aggctcccgg caaaggcctc gagtggattg gaaggattga ccccgccaac 600
gacaacaccc tgtacgccag caagttccaa ggaagggcca ccatctccgc cgacaccagc 660
aagaataccg cctacctgca gatgaactcc ctgagggctg aggacaccgc cgtgtactac 720
tgcggcagag gctacggcta ctacgtgttc gaccactggg gacagggcac actggtgaca 780
gtgagcagcg agaggaaaag ctgcgtggag tgccccccct gccctggcgg cggcagctcc 840
ggcggaggaa gcggaggaca acccagggag ccccaggtgt acacactccc ccctagcagg 900
gaagagatga ccaagaacca ggtgtccctg acctgcctcg tgaagggatt ctaccccagc 960
gacattgccg tcgagtggga gagcaacggc cagcctgaga acaactacaa gacaaccccc 1020
cctatgctcg atagcgatgg ctccttcttc ctgtactcca agctcaccgt cgacaagagc 1080
aggtggcagc agggcaacgt cttctcctgt agcgtgatgc acgaggctct gcacaaccac 1140
tacacccaga agagcctgag cctgagcccc ggctga                           1176


<210> 145
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M variable heavy (VH-K67R) sequence

<400> 145
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 146
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG4 EH

<400> 146
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Ser 
 1               5                  10                  15   
Ser Gly Gly Gly Ser Gly 
            20   


<210>  147
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IAB22 (CD8)

<400>  147

Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
145                 150                 155                 160 


Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Arg Ile 
                165                 170                 175     


Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe Gln Gly Lys 
            180                 185                 190         


Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Gly 
    210                 215                 220                 


Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375     

