                         SEQUENCE LISTING

<110>  LENTIGEN TECHNOLOGY, INC.
 
<120>  Compositions and Methods for Treating Cancer with Anti-CD19/CD22 
       Immunotherapy

<130>  42449-0031WO1

<150>  US 62/736,955
<151>  2018-09-26

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  2292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG2681 D0023 Leader - Construct CAR 2219

<400>  1
atgctcttgc tcgtgacttc tttgcttttg tgcgaacttc cgcacccagc cttccttttg       60

atacctcagg tacagcttca acaaagcgga ccgggacttg ttaagcattc ccaaaccctt      120

tctctcacgt gtgcaattag cggcgatagt gtatcctcta attctgcggc ctggaactgg      180

atacgacaat caccaagccg gggactcgag tggttgggcc gaacctacta tcggtccaaa      240

tggtataatg actacgcagt atccgtgaaa tctcgcatta cgatcaatcc agacacctcc      300

aaaaatcaat tttctctgca gttgaatagc gtgactcccg aggacacggc cgtttactat      360

tgcgcccagg aagttgaacc ccacgatgca tttgatattt ggggccaggg aaccatggtg      420

acagtgagta gtgggggtgg aggatctgga ggaggcggta gcggcggggg cggcagtgat      480

atccagatga cgcagtcacc ttccagcgtg tatgcgagtg tgggggacaa ggtcaccata      540

acctgtcgcg ctagccaaga tgtcagcggg tggctggctt ggtaccagca gaaaccaggt      600

ttggctcctc agcttttgat ctcaggagcg agcacgcttc agggtgaggt cccaagtcgc      660

tttagtggct ctggctccgg gacagacttc acgttgacga tcagcagttt gcagcctgag      720

gatttcgcga cctactactg ccagcaagcg aaatattttc cgtacacttt cggtcagggg      780

accaaattgg agatcaaagg tgggggtggt tcaggcggcg gaggctcagg cggcggcggt      840

agcggaggag gcggaagcgg gggtggcgga tcagaagtgc aactcgttca gagtggcgcg      900

gaggttaaga aacccggtgc atctgtaaag gttagctgta aggcatcagg atacactttt      960

accagctatt acatgcattg ggtgagacag gctcccggtc aggggctcga atggatgggg     1020

ttgatcaacc cgagtggtgg ttcaacatct tacgcccaga agtttcaggg ccgagtaaca     1080

atgactcggg acacgtctac ctcaactgtg tatatggagc tttccagcct gcgctcagag     1140

gatacagcag tctattactg cgcacggtca gacagaggta taacggccac tgatgcgttc     1200

gatatctggg gacaagggac tatggtaact gtgtcttccg gaggaggagg tagtggaggg     1260

ggaggaagcg gtgggggggg ctcacagtcc gttttgactc agccaccaag cgtctcagtc     1320

gcaccggggc gaatggcgaa aattacttgc ggcgggagcg acataggcaa caagaatgtg     1380

cattggtacc aacagaaacc aggtcaagca cctgttctcg tggtgtatga tgactacgat     1440

cgcccaagcg ggatcccgga gcggttctct ggatcaaatt ctggtgatgc agccactctg     1500

acaatatcaa cggtggaagt cggtgacgag gctgattact tctgccaagt atgggatggc     1560

agcggagatc cctactggat gtttggagga ggtactcaac tgacagttct gggcgcggcc     1620

gcaacgacca ctcctgcacc ccgccctccg actccggccc caaccattgc cagccagccc     1680

ctgtccctgc ggccggaagc ctgcagaccg gctgccggcg gagccgtcca tacccgggga     1740

ctggatttcg cctgcgatat ctatatctgg gcaccactcg ccggaacctg tggagtgctg     1800

ctgctgtccc ttgtgatcac cctgtactgc aagcgcggac ggaagaaact cttgtacatc     1860

ttcaagcagc cgttcatgcg ccctgtgcaa accacccaag aagaggacgg gtgctcctgc     1920

cggttcccgg aagaggaaga gggcggctgc gaactgcgcg tgaagttttc ccggtccgcc     1980

gacgctccgg cgtaccagca ggggcaaaac cagctgtaca acgaacttaa cctcggtcgc     2040

cgggaagaat atgacgtgct ggacaagcgg cggggaagag atcccgagat gggtggaaag     2100

ccgcggcgga agaaccctca ggagggcttg tacaacgagc tgcaaaagga caaaatggcc     2160

gaagcctact ccgagattgg catgaaggga gagcgcagac gcgggaaggg acacgatgga     2220

ctgtaccagg gactgtcaac cgcgactaag gacacttacg acgccctgca catgcaggcc     2280

ctgcccccgc gc                                                         2292


<210>  2
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG2681 D0023 Leader - Construct CAR 2219

<400>  2

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    290                 295                 300                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
305                 310                 315                 320 


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                325                 330                 335     


Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
            340                 345                 350         


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
        355                 360                 365             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe 
385                 390                 395                 400 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
            420                 425                 430         


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile 
        435                 440                 445             


Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln 
    450                 455                 460                 


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp 
465                 470                 475                 480 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp 
                485                 490                 495     


Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp 
            500                 505                 510         


Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe 
        515                 520                 525             


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
    530                 535                 540                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
545                 550                 555                 560 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                565                 570                 575     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            580                 585                 590         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        595                 600                 605             


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    610                 615                 620                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
625                 630                 635                 640 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                645                 650                 655     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            660                 665                 670         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        675                 680                 685             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    690                 695                 700                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
705                 710                 715                 720 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                725                 730                 735     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            740                 745                 750         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760                 


<210>  3
<211>  2292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG2791 D0024 Leader - construct CAR 1922

<400>  3
atgttgcttc tggttacttc ccttcttctt tgcgagcttc cacacccagc attcctgctc       60

attccggagg tgcaactcgt ccaatccggg gccgaagtta agaagccggg agcatctgtt      120

aaagtatcct gtaaggccag tgggtatact ttcacctcat attatatgca ctgggtgagg      180

caggctccag gccaagggtt ggagtggatg ggactgataa acccatctgg gggatcaact      240

tcttatgcgc aaaagttcca aggtcgggtc actatgacaa gggacacatc caccagcact      300

gtttatatgg aactgagcag cctgagatct gaggataccg cagtatatta ctgtgcacgc      360

agtgatagag gcataacggc gactgacgcc ttcgacattt ggggccaagg gacaatggtc      420

acggtttcaa gtggaggtgg agggtctggt ggcggggggt ctggtggtgg aggcagtcag      480

agcgtcctga cccagccgcc tagcgtcagt gtggcccccg gccgcatggc caagataacg      540

tgtggcggaa gcgatattgg gaataagaac gtccactggt atcagcagaa gccagggcag      600

gctcccgtcc tcgtagtata cgacgattat gatcggccca gtggaatccc cgagagattt      660

agcgggagta actctgggga tgcagcgaca cttactatct ccactgttga agtaggagac      720

gaggctgact atttttgtca ggtttgggac ggatccggag atccttattg gatgtttggc      780

ggaggtactc aattgaccgt gcttggaggt ggcggaggga gcgggggtgg gggctcaggg      840

ggaggtgggt caggcggggg cggaagtggt ggcgggggtt cccaagtcca actccagcag      900

tcaggacctg gactggtaaa acactctcaa accctgtctc tcacgtgtgc catatctggc      960

gatagtgtat cttcaaactc tgctgcatgg aactggatca ggcaaagtcc atcccgcggc     1020

cttgagtggc tcggtcgaac ctattaccga agcaaatggt acaacgatta tgcggtttca     1080

gtcaagtcaa gaattacgat caaccctgat acgagtaaga accagtttag tttgcaattg     1140

aacagtgtaa ctcccgagga cacggcggtg tactattgtg cgcaagaagt cgaaccgcat     1200

gatgcgttcg atatctgggg gcagggcaca atggtgaccg tatcttctgg cggcggcggc     1260

tctggaggag gaggaagcgg cggaggggga tctgacatac aaatgacaca atccccaagt     1320

tcagtatatg ctagcgtcgg ggataaagtg acaattactt gtagggcttc tcaagacgta     1380

agtggctggt tggcgtggta ccagcaaaag ccgggtctcg cccctcaact ccttatcagc     1440

ggagcttcaa ctcttcaggg agaggtccca agtcgattct caggctctgg ctccgggaca     1500

gatttcacct tgacaattag ttcactgcaa cccgaggatt tcgcaactta ctactgtcaa     1560

caggccaagt acttcccgta tacgtttggt caaggcacaa aactggagat taaggcggcc     1620

gcaacgacca ctcctgcacc ccgccctccg actccggccc caaccattgc cagccagccc     1680

ctgtccctgc ggccggaagc ctgcagaccg gctgccggcg gagccgtcca tacccgggga     1740

ctggatttcg cctgcgatat ctatatctgg gcaccactcg ccggaacctg tggagtgctg     1800

ctgctgtccc ttgtgatcac cctgtactgc aagcgcggac ggaagaaact cttgtacatc     1860

ttcaagcagc cgttcatgcg ccctgtgcaa accacccaag aagaggacgg gtgctcctgc     1920

cggttcccgg aagaggaaga gggcggctgc gaactgcgcg tgaagttttc ccggtccgcc     1980

gacgctccgg cgtaccagca ggggcaaaac cagctgtaca acgaacttaa cctcggtcgc     2040

cgggaagaat atgacgtgct ggacaagcgg cggggaagag atcccgagat gggtggaaag     2100

ccgcggcgga agaaccctca ggagggcttg tacaacgagc tgcaaaagga caaaatggcc     2160

gaagcctact ccgagattgg catgaaggga gagcgcagac gcgggaaggg acacgatgga     2220

ctgtaccagg gactgtcaac cgcgactaag gacacttacg acgccctgca catgcaggcc     2280

ctgcccccgc gc                                                         2292


<210>  4
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG2719 D0024 Leader - Construct CAR 1922

<400>  4

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met 
                165                 170                 175     


Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr 
                245                 250                 255     


Trp Met Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
    290                 295                 300                 


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
305                 310                 315                 320 


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
                325                 330                 335     


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
            340                 345                 350         


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
        355                 360                 365             


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
    370                 375                 380                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
385                 390                 395                 400 


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
            420                 425                 430         


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
        435                 440                 445             


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
    450                 455                 460                 


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
465                 470                 475                 480 


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
                485                 490                 495     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            500                 505                 510         


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
        515                 520                 525             


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr 
    530                 535                 540                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
545                 550                 555                 560 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                565                 570                 575     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            580                 585                 590         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        595                 600                 605             


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    610                 615                 620                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
625                 630                 635                 640 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                645                 650                 655     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            660                 665                 670         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        675                 680                 685             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    690                 695                 700                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
705                 710                 715                 720 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                725                 730                 735     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            740                 745                 750         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760                 


<210>  5
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CAR19 LTG2065

<400>  5
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctgga gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccagct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggattaatca accctagtgg tggtagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattaccgc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggcggagg aggctccggg ggaggaggtt ccgggggcgg gggttcccag      480

tctgtgctga ctcagccacc ctcggtgtca gtggccccag ggcggatggc caagattacc      540

tgtgggggaa gtgacattgg aaataaaaat gtccactggt atcagcagaa gccaggccag      600

gcccctgtcc tggttgtcta tgatgattac gaccggccct cagggatccc tgagcgattc      660

tctggctcca actctgggga cgcggccacc ctgacgatca gcacggtcga agtcggggat      720

gaggccgact atttctgtca ggtgtgggac ggtagtggtg atccttattg gatgttcggc      780

ggagggaccc agctcaccgt tttaggtgcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  6
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CAR19 LTG2065

<400>  6

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met 
                165                 170                 175     


Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr 
                245                 250                 255     


Trp Met Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  7
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse scFv CAR19 LTG1538

<400>  7
atgcttctcc tggtcacctc cctgctcctc tgcgaactgc ctcaccctgc cttccttctg       60

attcctgaca ttcagatgac tcagaccacc tcttccttgt ccgcgtcact gggagacaga      120

gtgaccatct cgtgtcgcgc aagccaggat atctccaagt acctgaactg gtaccaacag      180

aagcccgacg ggactgtgaa gctgctgatc taccacacct cacgcctgca cagcggagtg      240

ccaagcagat tctccggctc cggctcggga accgattact cgcttaccat tagcaacctc      300

gagcaggagg acatcgctac ctacttctgc cagcaaggaa ataccctgcc ctacaccttc      360

ggcggaggaa ccaaattgga aatcaccggc ggaggaggct ccgggggagg aggttccggg      420

ggcgggggtt ccgaagtgaa gctccaggag tccggccccg gcctggtggc gccgtcgcaa      480

tcactctctg tgacctgtac cgtgtcggga gtgtccctgc ctgattacgg cgtgagctgg      540

attcggcagc cgccgcggaa gggcctggaa tggctgggtg tcatctgggg atccgagact      600

acctactaca actcggccct gaagtcccgc ctgactatca tcaaagacaa ctcgaagtcc      660

caggtctttc tgaagatgaa ctccctgcaa actgacgaca ccgccatcta ttactgtgct      720

aagcactact actacggtgg aagctatgct atggactact gggggcaagg cacttcggtg      780

actgtgtcaa gcgcggccgc aactaccacc cctgcccctc ggccgccgac tccggcccca      840

accatcgcaa gccaacccct ctccttgcgc cccgaagctt gccgcccggc cgcgggtgga      900

gccgtgcata cccgggggct ggactttgcc tgcgatatct acatttgggc cccgctggcc      960

ggcacttgcg gcgtgctcct gctgtcgctg gtcatcaccc tttactgcaa gaggggccgg     1020

aagaagctgc tttacatctt caagcagccg ttcatgcggc ccgtgcagac gactcaggaa     1080

gaggacggat gctcgtgcag attccctgag gaggaagagg ggggatgcga actgcgcgtc     1140

aagttctcac ggtccgccga cgcccccgca tatcaacagg gccagaatca gctctacaac     1200

gagctgaacc tgggaaggag agaggagtac gacgtgctgg acaagcgacg cggacgcgac     1260

ccggagatgg gggggaaacc acggcggaaa aaccctcagg aaggactgta caacgaactc     1320

cagaaagaca agatggcgga agcctactca gaaatcggga tgaagggaga gcggaggagg     1380

ggaaagggtc acgacgggct gtaccaggga ctgagcaccg ccactaagga tacctacgat     1440

gccttgcata tgcaagcact cccaccccgg                                      1470


<210>  8
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse scFv CAR19 LTG1538

<400>  8

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
                165                 170                 175     


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
            180                 185                 190         


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
        195                 200                 205             


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
    210                 215                 220                 


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 


<210>  9
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR22 LTG2209

<400>  9
atgcttcttt tggtgacttc ccttttgctg tgcgagttgc cacaccccgc cttcctgctt       60

attccccagg tacagcttca acagagtggg ccgggactgg tgaaacactc ccaaacactt      120

tctctgacgt gcgctatatc aggtgactct gtttcatcta attctgctgc gtggaactgg      180

attcgacaat ctcccagtcg cgggttggaa tggctgggac gaacatatta tcggtctaag      240

tggtataacg attatgctgt atctgttaaa tctcgaatta cgattaatcc tgacacctcc      300

aagaaccagt tctccctcca gttgaactca gtcacaccgg aagacactgc ggtctactat      360

tgcgctcaag aagtcgagcc acatgatgca ttcgacatct ggggccaggg aacgatggtc      420

accgtcagca gtggcggcgg cggatctggg ggtggcggtt ctggcggtgg aggatcagac      480

atacaaatga cgcagagtcc ctcaagtgtg tacgcgagtg tgggggataa ggtaactatt      540

acgtgcagag cgtcacagga tgttagtgga tggcttgcct ggtatcagca gaagccaggc      600

cttgctccac agctccttat cagtggtgct tctacacttc agggcgaggt tccgagtaga      660

ttctctggtt ctggatctgg tactgacttc actcttacaa tttcttcttt gcaaccagaa      720

gactttgcga cttattactg ccaacaggcc aaatacttcc cttatacatt tggccaaggt      780

accaagttgg agataaaggc ggccgcaact accacccctg cccctcggcc gccgactccg      840

gccccaacca tcgcaagcca acccctctcc ttgcgccccg aagcttgccg cccggccgcg      900

ggtggagccg tgcatacccg ggggctggac tttgcctgcg atatctacat ttgggccccg      960

ctggccggca cttgcggcgt gctcctgctg tcgctggtca tcacccttta ctgcaagagg     1020

ggccggaaga agctgcttta catcttcaag cagccgttca tgcggcccgt gcagacgact     1080

caggaagagg acggatgctc gtgcagattc cctgaggagg aagagggggg atgcgaactg     1140

cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc     1200

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga     1260

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac     1320

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg     1380

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc     1440

tacgatgcct tgcatatgca agcactccca ccccgg                               1476


<210>  10
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD22A 1495

<400>  10

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  11
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader/signal peptide sequence

<400>  11
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccg                                                                  66


<210>  12
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader/signal peptide sequence

<400>  12

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  13

<400>  13
000

<210>  14

<400>  14
000

<210>  15

<400>  15
000

<210>  16

<400>  16
000

<210>  17

<400>  17
000

<210>  18

<400>  18
000

<210>  19

<400>  19
000

<210>  20

<400>  20
000

<210>  21

<400>  21
000

<210>  22

<400>  22
000

<210>  23

<400>  23
000

<210>  24

<400>  24
000

<210>  25

<400>  25
000

<210>  26

<400>  26
000

<210>  27

<400>  27
000

<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA CD8 transmembrane domain

<400>  35
atttgggccc cgctggccgg cacttgcggc gtgctcctgc tgtcgctggt catcaccctt       60

tactgc                                                                  66


<210>  36
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  36

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210>  37
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA CD8 hinge domain

<400>  37
actaccaccc ctgcccctcg gccgccgact ccggccccaa ccatcgcaag ccaacccctc       60

tccttgcgcc ccgaagcttg ccgcccggcc gcgggtggag ccgtgcatac ccgggggctg      120

gactttgcct gcgatatcta c                                                141


<210>  38
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain

<400>  38

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  39
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid numbers 137 to 206 hinge and  transmembrane region of 
       CD8.alpha.

<400>  39

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  40
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signaling domain of 4-1BB

<400>  40
aagaggggcc ggaagaagct gctttacatc ttcaagcagc cgttcatgcg gcccgtgcag       60

acgactcagg aagaggacgg atgctcgtgc agattccctg aggaggaaga ggggggatgc      120

gaactg                                                                 126


<210>  41
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signaling domain of 4-1BB

<400>  41

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  42
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signaling domain of CD3-zeta

<400>  42
cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc       60

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga      120

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac      180

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg      240

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc      300

tacgatgcct tgcatatgca agcactccca ccccgg                                336


<210>  43
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta

<400>  43

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  44
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScFv CD19 (FMC63)

<400>  44
gacattcaga tgactcagac cacctcttcc ttgtccgcgt cactgggaga cagagtgacc       60

atctcgtgtc gcgcaagcca ggatatctcc aagtacctga actggtacca acagaagccc      120

gacgggactg tgaagctgct gatctaccac acctcacgcc tgcacagcgg agtgccaagc      180

agattctccg gctccggctc gggaaccgat tactcgctta ccattagcaa cctcgagcag      240

gaggacatcg ctacctactt ctgccagcaa ggaaataccc tgccctacac cttcggcgga      300

ggaaccaaat tggaaatcac cggcggagga ggctccgggg gaggaggttc cgggggcggg      360

ggttccgaag tgaagctcca ggagtccggc cccggcctgg tggcgccgtc gcaatcactc      420

tctgtgacct gtaccgtgtc gggagtgtcc ctgcctgatt acggcgtgag ctggattcgg      480

cagccgccgc ggaagggcct ggaatggctg ggtgtcatct ggggatccga gactacctac      540

tacaactcgg ccctgaagtc ccgcctgact atcatcaaag acaactcgaa gtcccaggtc      600

tttctgaaga tgaactccct gcaaactgac gacaccgcca tctattactg tgctaagcac      660

tactactacg gtggaagcta tgctatggac tactgggggc aaggcacttc ggtgactgtg      720

tcaagc                                                                 726


<210>  45
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScFv CD19 (FMC63)

<400>  45

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  46
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR (LTG1936)

<400>  46
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcagg tgcagctggt gcaatctggg gcagaggtga aaaagcccgg ggagtctctg      120

aggatctcct gtaagggttc tggattcagt tttcccacct actggatcgg ctgggtgcgc      180

cagatgcccg ggaaaggcct ggagtggatg gggatcatct atcctggtga ctctgatacc      240

agatacagcc cgtccttcca aggccaggtc accatctcag ccgacaagtc catcagcacc      300

gcctacctgc agtggagcag cctgaaggcc tcggacaccg ccatgtatta ctgtgcgaga      360

ctagttggag atggctacaa tacgggggct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggaggtgg cgggtctggt ggtggcggta gcggtggtgg cggatccgat      480

attgtgatga cccacactcc actctctctg tccgtcaccc ctggacagcc ggcctccatc      540

tcctgcaagt ctagtcagag cctcctgcat agtaatggaa agacctattt gtattggtac      600

ctgcagaagc caggccagcc tccacagctc ctgatctatg gagcttccaa ccggttctct      660

ggagtgccag acaggttcag tggcagcggg tcagggacag atttcacact gaaaatcagc      720

cgggtggagg ctgaggatgt tggggtttat tactgcatgc aaagtataca gcttcctatc      780

accttcggcc aagggacacg actggagatt aaagcggccg caactaccac ccctgcccct      840

cggccgccga ctccggcccc aaccatcgca agccaacccc tctccttgcg ccccgaagct      900

tgccgcccgg ccgcgggtgg agccgtgcat acccgggggc tggactttgc ctgcgatatc      960

tacatttggg ccccgctggc cggcacttgc ggcgtgctcc tgctgtcgct ggtcatcacc     1020

ctttactgca agaggggccg gaagaagctg ctttacatct tcaagcagcc gttcatgcgg     1080

cccgtgcaga cgactcagga agaggacgga tgctcgtgca gattccctga ggaggaagag     1140

gggggatgcg aactgcgcgt caagttctca cggtccgccg acgcccccgc atatcaacag     1200

ggccagaatc agctctacaa cgagctgaac ctgggaagga gagaggagta cgacgtgctg     1260

gacaagcgac gcggacgcga cccggagatg ggggggaaac cacggcggaa aaaccctcag     1320

gaaggactgt acaacgaact ccagaaagac aagatggcgg aagcctactc agaaatcggg     1380

atgaagggag agcggaggag gggaaagggt cacgacgggc tgtaccaggg actgagcacc     1440

gccactaagg atacctacga tgccttgcat atgcaagcac tcccaccccg g              1491


<210>  47
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR (LTG1936)

<400>  47

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly 
        35                  40                  45              


Phe Ser Phe Pro Thr Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
65                  70                  75                  80  


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
            100                 105                 110         


Thr Ala Met Tyr Tyr Cys Ala Arg Leu Val Gly Asp Gly Tyr Asn Thr 
        115                 120                 125             


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Met Thr His Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln 
                165                 170                 175     


Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser Asn 
            180                 185                 190         


Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        195                 200                 205             


Gln Leu Leu Ile Tyr Gly Ala Ser Asn Arg Phe Ser Gly Val Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser Ile 
                245                 250                 255     


Gln Leu Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ala 
            260                 265                 270         


Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        275                 280                 285             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    290                 295                 300                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
305                 310                 315                 320 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
                325                 330                 335     


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            340                 345                 350         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        355                 360                 365             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375                 380                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


<210>  48
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-mesothelin CAR (LTG1904)

<400>  48
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctggg ggaggcttgg tacagcctgg ggggtccctg      120

agactctcct gtgcagcctc tggattcacc tttgatgatt atgccatgca ctgggtccgg      180

caagctccag ggaagggcct ggagtgggtc tcaggtatta gttggaatag tggtagcata      240

ggctatgcgg actctgtgaa gggccgattc accatctcca gagacaacgc caagaactcc      300

ctgtatctgc aaatgaacag tctgagagct gaggacacgg ccttgtatta ctgtgcaaaa      360

gatttatcgt cagtggctgg accctttaac tactggggcc agggcaccct ggtcaccgtc      420

tcctcaggag gtggcgggtc tggtggaggc ggtagcggcg gtggcggatc ctcttctgag      480

ctgactcagg accctgctgt gtctgtggcc ttgggacaga cagtcaggat cacatgccaa      540

ggagacagcc tcagaagcta ttatgcaagc tggtaccagc agaagccagg acaggcccct      600

gtacttgtca tctatggtaa aaacaaccgg ccctcaggga tcccagaccg attctctggc      660

tccagctcag gaaacacagc ttccttgacc atcactgggg ctcaggcgga ggatgaggct      720

gactattact gtaactcccg ggacagcagt ggtaaccatc tggtattcgg cggaggcacc      780

cagctgaccg tcctcggtgc ggccgcaact accacccctg cccctcggcc gccgactccg      840

gccccaacca tcgcaagcca acccctctcc ttgcgccccg aagcttgccg cccggccgcg      900

ggtggagccg tgcatacccg ggggctggac tttgcctgcg atatctacat ttgggccccg      960

ctggccggca cttgcggcgt gctcctgctg tcgctggtca tcacccttta ctgcaagagg     1020

ggccggaaga agctgcttta catcttcaag cagccgttca tgcggcccgt gcagacgact     1080

caggaagagg acggatgctc gtgcagattc cctgaggagg aagagggggg atgcgaactg     1140

cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc     1200

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga     1260

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac     1320

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg     1380

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc     1440

tacgatgcct tgcatatgca agcactccca ccccgg                               1476


<210>  49
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-mesothelin CAR (LTG1904)

<400>  49

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile 
65                  70                  75                  80  


Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Leu Ser Ser Val Ala Gly Pro 
        115                 120                 125             


Phe Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Glu 
145                 150                 155                 160 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
                165                 170                 175     


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        195                 200                 205             


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Leu Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  50
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain scFv 16P17

<400>  50
caggtacagc ttcaacagag tgggccggga ctggtgaaac actcccaaac actttctctg       60

acgtgcgcta tatcaggtga ctctgtttca tctaattctg ctgcgtggaa ctggattcga      120

caatctccca gtcgcgggtt ggaatggctg ggacgaacat attatcggtc taagtggtat      180

aacgattatg ctgtatctgt taaatctcga attacgatta atcctgacac ctccaagaac      240

cagttctccc tccagttgaa ctcagtcaca ccggaagaca ctgcggtcta ctattgcgct      300

caagaagtcg agccacatga tgcattcgac atctggggcc agggaacgat ggtcaccgtc      360

agcagt                                                                 366


<210>  51
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain scFv 16P17

<400>  51

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys His Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Gln Glu Val Glu Pro His Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  52
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain scFv 16P17

<400>  52
gacatacaaa tgacgcagag tccctcaagt gtgtacgcga gtgtggggga taaggtaact       60

attacgtgca gagcgtcaca ggatgttagt ggatggcttg cctggtatca gcagaagcca      120

ggccttgctc cacagctcct tatcagtggt gcttctacac ttcagggcga ggttccgagt      180

agattctctg gttctggatc tggtactgac ttcactctta caatttcttc tttgcaacca      240

gaagactttg cgacttatta ctgccaacag gccaaatact tcccttatac atttggccaa      300

ggtaccaagt tggagataaa g                                                321


<210>  53
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain scFv 16P17

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  54
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain scFv M19217-1

<400>  54
gaggtccagc tggtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatta atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatcggat      300

cggggaatta ccgccacgga cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210>  55
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain scFv M19217-1

<400>  55

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  56
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain scFv M19217-1

<400>  56
cagtctgtgc tgactcagcc accctcggtg tcagtggccc cagggcggat ggccaagatt       60

acctgtgggg gaagtgacat tggaaataaa aatgtccact ggtatcagca gaagccaggc      120

caggcccctg tcctggttgt ctatgatgat tacgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg ggacgcggcc accctgacga tcagcacggt cgaagtcggg      240

gatgaggccg actatttctg tcaggtgtgg gacggtagtg gtgatcctta ttggatgttc      300

ggcggaggga cccagctcac cgttttaggt                                       330


<210>  57
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain scFv M19217-1

<400>  57

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg 
1               5                   10                  15      


Met Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Tyr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro 
                85                  90                  95      


Tyr Trp Met Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  58
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR22 LTG2200 (M971-CD8TM-4-1BB-zeta)

<400>  58
atgcttcttt tggtgacttc ccttttgctg tgcgagttgc cacaccccgc cttcctgctt       60

attccccagg tacagctcca gcagagtggc ccagggctcg tgaagccaag ccagacgctg      120

tccctgactt gtgcaatttc aggggattca gtttcatcaa atagcgcggc gtggaattgg      180

attcgacaat ctccttcccg agggttggaa tggcttggac gaacatatta cagatccaaa      240

tggtataacg actatgcggt atcagtaaag tcaagaataa ccattaaccc cgacacaagc      300

aagaaccaat tctctttgca gcttaactct gtcacgccag aagacacggc agtctattat      360

tgcgctcgcg aggtaacggg tgacctggaa gacgcttttg acatttgggg gcagggtacg      420

atggtgacag tcagttcagg gggcggtggg agtgggggag ggggtagcgg ggggggaggg      480

tcagacattc agatgaccca gtccccttca tccttgtctg cctccgtcgg tgacagggtg      540

acaataacat gcagagcaag ccaaacaatc tggagctatc tcaactggta ccagcagcga      600

ccaggaaaag cgccaaacct gctgatttac gctgcttcct ccctccaatc aggcgtgcct      660

agtagattta gcggtagggg ctccggcacc gattttacgc tcactataag ctctcttcaa      720

gcagaagatt ttgcgactta ttactgccag cagtcctata gtatacctca gactttcgga      780

cagggtacca agttggagat taaggcggcc gcaactacca cccctgcccc tcggccgccg      840

actccggccc caaccatcgc aagccaaccc ctctccttgc gccccgaagc ttgccgcccg      900

gccgcgggtg gagccgtgca tacccggggg ctggactttg cctgcgatat ctacatttgg      960

gccccgctgg ccggcacttg cggcgtgctc ctgctgtcgc tggtcatcac cctttactgc     1020

aagaggggcc ggaagaagct gctttacatc ttcaagcagc cgttcatgcg gcccgtgcag     1080

acgactcagg aagaggacgg atgctcgtgc agattccctg aggaggaaga ggggggatgc     1140

gaactgcgcg tcaagttctc acggtccgcc gacgcccccg catatcaaca gggccagaat     1200

cagctctaca acgagctgaa cctgggaagg agagaggagt acgacgtgct ggacaagcga     1260

cgcggacgcg acccggagat gggggggaaa ccacggcgga aaaaccctca ggaaggactg     1320

tacaacgaac tccagaaaga caagatggcg gaagcctact cagaaatcgg gatgaaggga     1380

gagcggagga ggggaaaggg tcacgacggg ctgtaccagg gactgagcac cgccactaag     1440

gatacctacg atgccttgca tatgcaagca ctcccacccc gg                        1482


<210>  59
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR22 LTG2200 (M971-CD8TM-4-1BB-zeta)

<400>  59

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp 
        115                 120                 125             


Leu Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                165                 170                 175     


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser 
            180                 185                 190         


Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu 
        195                 200                 205             


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    210                 215                 220                 


Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro 
                245                 250                 255     


Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  60
<211>  2292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR LTG2737 (CD22-19 CD8 BBz)

<400>  60
atgctcttgc tcgtgacttc tttgcttttg tgcgaacttc cgcacccagc cttccttttg       60

atacctcagg tacagcttca acaaagcgga ccgggacttg ttaagcattc ccaaaccctt      120

tctctcacgt gtgcaattag cggcgatagt gtatcctcta attctgcggc ctggaactgg      180

atacgacaat caccaagccg gggactcgag tggttgggcc gaacctacta tcggtccaaa      240

tggtataatg actacgcagt atccgtgaaa tctcgcatta cgatcaatcc agacacctcc      300

aaaaatcaat tttctctgca gttgaatagc gtgactcccg aggacacggc cgtttactat      360

tgcgcccagg aagttgaacc ccacgatgca tttgatattt ggggccaggg aaccatggtg      420

acagtgagta gtgggggtgg aggatctgga ggaggcggta gcggcggggg cggcagtgat      480

atccagatga cgcagtcacc ttccagcgtg tatgcgagtg tgggggacaa ggtcaccata      540

acctgtcgcg ctagccaaga tgtcagcggg tggctggctt ggtaccagca gaaaccaggt      600

ttggctcctc agcttttgat ctcaggagcg agcacgcttc agggtgaggt cccaagtcgc      660

tttagtggct ctggctccgg gacagacttc acgttgacga tcagcagttt gcagcctgag      720

gatttcgcga cctactactg ccagcaagcg aaatattttc cgtacacttt cggtcagggg      780

accaaattgg agatcaaagg tgggggtggt tcaggcggcg gaggctcagg cggcggcggt      840

agcggaggag gcggaagcgg gggtggcgga tcagaagtgc aactcgttca gagtggcgcg      900

gaggttaaga aacccggtgc atctgtaaag gttagctgta aggcatcagg atacactttt      960

accagctatt acatgcattg ggtgagacag gctcccggtc aggggctcga atggatgggg     1020

ttgatcaacc cgagtggtgg ttcaacatct tacgcccaga agtttcaggg ccgagtaaca     1080

atgactcggg acacgtctac ctcaactgtg tatatggagc tttccagcct gcgctcagag     1140

gatacagcag tctattactg cgcacggtca gacagaggta taacggccac tgatgcgttc     1200

gatatctggg gacaagggac tatggtaact gtgtcttccg gaggaggagg tagtggaggg     1260

ggaggaagcg gtgggggggg ctcacagtcc gttttgactc agccaccaag cgtctcagtc     1320

gcaccggggc gaatggcgaa aattacttgc ggcgggagcg acataggcaa caagaatgtg     1380

cattggtacc aacagaaacc aggtcaagca cctgttctcg tggtgtatga tgactacgat     1440

cgcccaagcg ggatcccgga gcggttctct ggatcaaatt ctggtgatgc agccactctg     1500

acaatatcaa cggtggaagt cggtgacgag gctgattact tctgccaagt atgggatggc     1560

agcggagatc cctactggat gtttggagga ggtactcaac tgacagttct gggcgcggcc     1620

gcaacgacca ctcctgcacc ccgccctccg actccggccc caaccattgc cagccagccc     1680

ctgtccctgc ggccggaagc ctgcagaccg gctgccggcg gagccgtcca tacccgggga     1740

ctggatttcg cctgcgatat ctatatctgg gcaccactcg ccggaacctg tggagtgctg     1800

ctgctgtccc ttgtgatcac cctgtactgc aagcgcggac ggaagaaact cttgtacatc     1860

ttcaagcagc cgttcatgcg ccctgtgcaa accacccaag aagaggacgg gtgctcctgc     1920

cggttcccgg aagaggaaga gggcggctgc gaactgcgcg tgaagttttc ccggtccgcc     1980

gacgctccgg cgtaccagca ggggcaaaac cagctgtaca acgaacttaa cctcggtcgc     2040

cgggaagaat atgacgtgct ggacaagcgg cggggaagag atcccgagat gggtggaaag     2100

ccgcggcgga agaaccctca ggagggcttg tacaacgagc tgcaaaagga caaaatggcc     2160

gaagcctact ccgagattgg catgaaggga gagcgcagac gcgggaaggg acacgatgga     2220

ctgtaccagg gactgtcaac cgcgactaag gacacttacg acgccctgca catgcaggcc     2280

ctgcccccgc gc                                                         2292


<210>  61
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR LTG2737 CD22-19 CD8 BBz

<400>  61

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    290                 295                 300                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
305                 310                 315                 320 


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                325                 330                 335     


Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
            340                 345                 350         


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
        355                 360                 365             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe 
385                 390                 395                 400 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
            420                 425                 430         


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile 
        435                 440                 445             


Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln 
    450                 455                 460                 


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp 
465                 470                 475                 480 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp 
                485                 490                 495     


Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp 
            500                 505                 510         


Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe 
        515                 520                 525             


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
    530                 535                 540                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
545                 550                 555                 560 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                565                 570                 575     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            580                 585                 590         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        595                 600                 605             


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    610                 615                 620                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
625                 630                 635                 640 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                645                 650                 655     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            660                 665                 670         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        675                 680                 685             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    690                 695                 700                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
705                 710                 715                 720 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                725                 730                 735     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            740                 745                 750         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760                 


<210>  62
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR D0135 CD22-19 CD8 CD28z

<400>  62
atgctcttgc tcgtgacttc tttgcttttg tgcgaacttc cgcacccagc cttccttttg       60

atacctcagg tacagcttca acaaagcgga ccgggacttg ttaagcattc ccaaaccctt      120

tctctcacgt gtgcaattag cggcgatagt gtatcctcta attctgcggc ctggaactgg      180

atacgacaat caccaagccg gggactcgag tggttgggcc gaacctacta tcggtccaaa      240

tggtataatg actacgcagt atccgtgaaa tctcgcatta cgatcaatcc agacacctcc      300

aaaaatcaat tttctctgca gttgaatagc gtgactcccg aggacacggc cgtttactat      360

tgcgcccagg aagttgaacc ccacgatgca tttgatattt ggggccaggg aaccatggtg      420

acagtgagta gtgggggtgg aggatctgga ggaggcggta gcggcggggg cggcagtgat      480

atccagatga cgcagtcacc ttccagcgtg tatgcgagtg tgggggacaa ggtcaccata      540

acctgtcgcg ctagccaaga tgtcagcggg tggctggctt ggtaccagca gaaaccaggt      600

ttggctcctc agcttttgat ctcaggagcg agcacgcttc agggtgaggt cccaagtcgc      660

tttagtggct ctggctccgg gacagacttc acgttgacga tcagcagttt gcagcctgag      720

gatttcgcga cctactactg ccagcaagcg aaatattttc cgtacacttt cggtcagggg      780

accaaattgg agatcaaagg tgggggtggt tcaggcggcg gaggctcagg cggcggcggt      840

agcggaggag gcggaagcgg gggtggcgga tcagaagtgc aactcgttca gagtggcgcg      900

gaggttaaga aacccggtgc atctgtaaag gttagctgta aggcatcagg atacactttt      960

accagctatt acatgcattg ggtgagacag gctcccggtc aggggctcga atggatgggg     1020

ttgatcaacc cgagtggtgg ttcaacatct tacgcccaga agtttcaggg ccgagtaaca     1080

atgactcggg acacgtctac ctcaactgtg tatatggagc tttccagcct gcgctcagag     1140

gatacagcag tctattactg cgcacggtca gacagaggta taacggccac tgatgcgttc     1200

gatatctggg gacaagggac tatggtaact gtgtcttccg gaggaggagg tagtggaggg     1260

ggaggaagcg gtgggggggg ctcacagtcc gttttgactc agccaccaag cgtctcagtc     1320

gcaccggggc gaatggcgaa aattacttgc ggcgggagcg acataggcaa caagaatgtg     1380

cattggtacc aacagaaacc aggtcaagca cctgttctcg tggtgtatga tgactacgat     1440

cgcccaagcg ggatcccgga gcggttctct ggatcaaatt ctggtgatgc agccactctg     1500

acaatatcaa cggtggaagt cggtgacgag gctgattact tctgccaagt atgggatggc     1560

agcggagatc cctactggat gtttggagga ggtactcaac tgacagttct gggcgcggcc     1620

gcgactacca ctcctgcacc acggccacct accccagccc ccaccattgc aagccagcca     1680

ctttcactgc gccccgaagc gtgtagacca gctgctggag gagccgtgca tacccgaggg     1740

ctggacttcg cctgtgacat ctacatctgg gccccattgg ctggaacttg cggcgtgctg     1800

ctcttgtctc tggtcattac cctgtactgc cggtcgaaga ggtccagact cttgcactcc     1860

gactacatga acatgactcc tagaaggccc ggacccacta gaaagcacta ccagccgtac     1920

gcccctcctc gggatttcgc cgcataccgg tccagagtga agttcagccg ctcagccgat     1980

gcaccggcct accagcaggg acagaaccag ctctacaacg agctcaacct gggtcggcgg     2040

gaagaatatg acgtgctgga caaacggcgc ggcagagatc cggagatggg gggaaagccg     2100

aggaggaaga accctcaaga gggcctgtac aacgaactgc agaaggacaa gatggcggaa     2160

gcctactccg agatcggcat gaagggagaa cgccggagag ggaagggtca tgacggactg     2220

taccagggcc tgtcaactgc cactaaggac acttacgatg cgctccatat gcaagctttg     2280

cccccgcgg                                                             2289


<210>  63
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0135 CD22-19 CD8 CD28z

<400>  63

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    290                 295                 300                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
305                 310                 315                 320 


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                325                 330                 335     


Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
            340                 345                 350         


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
        355                 360                 365             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe 
385                 390                 395                 400 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
            420                 425                 430         


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile 
        435                 440                 445             


Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln 
    450                 455                 460                 


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp 
465                 470                 475                 480 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp 
                485                 490                 495     


Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp 
            500                 505                 510         


Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe 
        515                 520                 525             


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
    530                 535                 540                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
545                 550                 555                 560 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                565                 570                 575     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            580                 585                 590         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        595                 600                 605             


Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
    610                 615                 620                 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
625                 630                 635                 640 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
                645                 650                 655     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            660                 665                 670         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        675                 680                 685             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    690                 695                 700                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
705                 710                 715                 720 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                725                 730                 735     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            740                 745                 750         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760             


<210>  64
<211>  2277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR D0136 CD22-19 CD8 ICOSz DNA

<400>  64
atgctcttgc tcgtgacttc tttgcttttg tgcgaacttc cgcacccagc cttccttttg       60

atacctcagg tacagcttca acaaagcgga ccgggacttg ttaagcattc ccaaaccctt      120

tctctcacgt gtgcaattag cggcgatagt gtatcctcta attctgcggc ctggaactgg      180

atacgacaat caccaagccg gggactcgag tggttgggcc gaacctacta tcggtccaaa      240

tggtataatg actacgcagt atccgtgaaa tctcgcatta cgatcaatcc agacacctcc      300

aaaaatcaat tttctctgca gttgaatagc gtgactcccg aggacacggc cgtttactat      360

tgcgcccagg aagttgaacc ccacgatgca tttgatattt ggggccaggg aaccatggtg      420

acagtgagta gtgggggtgg aggatctgga ggaggcggta gcggcggggg cggcagtgat      480

atccagatga cgcagtcacc ttccagcgtg tatgcgagtg tgggggacaa ggtcaccata      540

acctgtcgcg ctagccaaga tgtcagcggg tggctggctt ggtaccagca gaaaccaggt      600

ttggctcctc agcttttgat ctcaggagcg agcacgcttc agggtgaggt cccaagtcgc      660

tttagtggct ctggctccgg gacagacttc acgttgacga tcagcagttt gcagcctgag      720

gatttcgcga cctactactg ccagcaagcg aaatattttc cgtacacttt cggtcagggg      780

accaaattgg agatcaaagg tgggggtggt tcaggcggcg gaggctcagg cggcggcggt      840

agcggaggag gcggaagcgg gggtggcgga tcagaagtgc aactcgttca gagtggcgcg      900

gaggttaaga aacccggtgc atctgtaaag gttagctgta aggcatcagg atacactttt      960

accagctatt acatgcattg ggtgagacag gctcccggtc aggggctcga atggatgggg     1020

ttgatcaacc cgagtggtgg ttcaacatct tacgcccaga agtttcaggg ccgagtaaca     1080

atgactcggg acacgtctac ctcaactgtg tatatggagc tttccagcct gcgctcagag     1140

gatacagcag tctattactg cgcacggtca gacagaggta taacggccac tgatgcgttc     1200

gatatctggg gacaagggac tatggtaact gtgtcttccg gaggaggagg tagtggaggg     1260

ggaggaagcg gtgggggggg ctcacagtcc gttttgactc agccaccaag cgtctcagtc     1320

gcaccggggc gaatggcgaa aattacttgc ggcgggagcg acataggcaa caagaatgtg     1380

cattggtacc aacagaaacc aggtcaagca cctgttctcg tggtgtatga tgactacgat     1440

cgcccaagcg ggatcccgga gcggttctct ggatcaaatt ctggtgatgc agccactctg     1500

acaatatcaa cggtggaagt cggtgacgag gctgattact tctgccaagt atgggatggc     1560

agcggagatc cctactggat gtttggagga ggtactcaac tgacagttct gggcgcggcc     1620

gcgactacca ctcctgcacc acggccacct accccagccc ccaccattgc aagccagcca     1680

ctttcactgc gccccgaagc gtgtagacca gctgctggag gagccgtgca tacccgaggg     1740

ctggacttcg cctgtgacat ctacatctgg gccccattgg ctggaacttg cggcgtgctg     1800

ctcttgtctc tggtcattac cctgtactgc tggctgacaa aaaagaagta ttcatctagt     1860

gtacatgatc cgaacggtga atacatgttc atgcgcgcgg tgaacacggc caagaagagc     1920

agactgaccg acgtaaccct tagagtgaag ttcagccgct cagccgatgc accggcctac     1980

cagcagggac agaaccagct ctacaacgag ctcaacctgg gtcggcggga agaatatgac     2040

gtgctggaca aacggcgcgg cagagatccg gagatggggg gaaagccgag gaggaagaac     2100

cctcaagagg gcctgtacaa cgaactgcag aaggacaaga tggcggaagc ctactccgag     2160

atcggcatga agggagaacg ccggagaggg aagggtcatg acggactgta ccagggcctg     2220

tcaactgcca ctaaggacac ttacgatgcg ctccatatgc aagctttgcc cccgcgg        2277


<210>  65
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0136 CD22-19 CD8 ICOSz

<400>  65

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    290                 295                 300                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
305                 310                 315                 320 


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                325                 330                 335     


Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
            340                 345                 350         


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
        355                 360                 365             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe 
385                 390                 395                 400 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
            420                 425                 430         


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile 
        435                 440                 445             


Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln 
    450                 455                 460                 


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp 
465                 470                 475                 480 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp 
                485                 490                 495     


Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp 
            500                 505                 510         


Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe 
        515                 520                 525             


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
    530                 535                 540                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
545                 550                 555                 560 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                565                 570                 575     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            580                 585                 590         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        595                 600                 605             


Tyr Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
    610                 615                 620                 


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
625                 630                 635                 640 


Arg Leu Thr Asp Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
                645                 650                 655     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            660                 665                 670         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        675                 680                 685             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    690                 695                 700                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
705                 710                 715                 720 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                725                 730                 735     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            740                 745                 750         


Met Gln Ala Leu Pro Pro Arg 
        755                 


<210>  66
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR D0137 CD22-19 CD8 OX40TM OX40z

<400>  66
atgctcttgc tcgtgacttc tttgcttttg tgcgaacttc cgcacccagc cttccttttg       60

atacctcagg tacagcttca acaaagcgga ccgggacttg ttaagcattc ccaaaccctt      120

tctctcacgt gtgcaattag cggcgatagt gtatcctcta attctgcggc ctggaactgg      180

atacgacaat caccaagccg gggactcgag tggttgggcc gaacctacta tcggtccaaa      240

tggtataatg actacgcagt atccgtgaaa tctcgcatta cgatcaatcc agacacctcc      300

aaaaatcaat tttctctgca gttgaatagc gtgactcccg aggacacggc cgtttactat      360

tgcgcccagg aagttgaacc ccacgatgca tttgatattt ggggccaggg aaccatggtg      420

acagtgagta gtgggggtgg aggatctgga ggaggcggta gcggcggggg cggcagtgat      480

atccagatga cgcagtcacc ttccagcgtg tatgcgagtg tgggggacaa ggtcaccata      540

acctgtcgcg ctagccaaga tgtcagcggg tggctggctt ggtaccagca gaaaccaggt      600

ttggctcctc agcttttgat ctcaggagcg agcacgcttc agggtgaggt cccaagtcgc      660

tttagtggct ctggctccgg gacagacttc acgttgacga tcagcagttt gcagcctgag      720

gatttcgcga cctactactg ccagcaagcg aaatattttc cgtacacttt cggtcagggg      780

accaaattgg agatcaaagg tgggggtggt tcaggcggcg gaggctcagg cggcggcggt      840

agcggaggag gcggaagcgg gggtggcgga tcagaagtgc aactcgttca gagtggcgcg      900

gaggttaaga aacccggtgc atctgtaaag gttagctgta aggcatcagg atacactttt      960

accagctatt acatgcattg ggtgagacag gctcccggtc aggggctcga atggatgggg     1020

ttgatcaacc cgagtggtgg ttcaacatct tacgcccaga agtttcaggg ccgagtaaca     1080

atgactcggg acacgtctac ctcaactgtg tatatggagc tttccagcct gcgctcagag     1140

gatacagcag tctattactg cgcacggtca gacagaggta taacggccac tgatgcgttc     1200

gatatctggg gacaagggac tatggtaact gtgtcttccg gaggaggagg tagtggaggg     1260

ggaggaagcg gtgggggggg ctcacagtcc gttttgactc agccaccaag cgtctcagtc     1320

gcaccggggc gaatggcgaa aattacttgc ggcgggagcg acataggcaa caagaatgtg     1380

cattggtacc aacagaaacc aggtcaagca cctgttctcg tggtgtatga tgactacgat     1440

cgcccaagcg ggatcccgga gcggttctct ggatcaaatt ctggtgatgc agccactctg     1500

acaatatcaa cggtggaagt cggtgacgag gctgattact tctgccaagt atgggatggc     1560

agcggagatc cctactggat gtttggagga ggtactcaac tgacagttct gggcgcggcc     1620

gcaacgacca ctccagcacc gagaccgcca acccccgcgc ctaccatcgc aagtcaacca     1680

ctttctctca ggcctgaagc gtgccgacct gcagctggtg gggcagtaca taccaggggt     1740

ttggacttcg catgtgacgt ggcggcaatt ctcggcctgg gacttgtcct tggtctgctt     1800

ggtccgctcg caatacttct ggccttgtac ctgctccgca gagaccaaag acttccgccc     1860

gacgcccaca agcccccagg aggaggttcc ttcagaacgc ctatacaaga agaacaagca     1920

gatgcccact ctaccctggc taaaatcagg gtgaagttta gccggtcagc tgatgcacct     1980

gcatatcagc agggacagaa ccagctgtac aatgagctga acctcggacg aagagaggag     2040

tacgacgtgt tggacaaaag acgaggtaga gaccccgaga tgggcggcaa gccgagaaga     2100

aaaaacccac aagaagggct ttataatgag cttcagaaag ataagatggc agaggcctac     2160

agtgagattg gcatgaaggg cgaaagaagg aggggcaaag gacacgacgg tctctaccaa     2220

ggcctcagca cggctaccaa agatacgtat gacgcattgc atatgcaggc attgccgccc     2280

cgc                                                                   2283


<210>  67
<211>  760
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0137 CD22-19 CD8 OX40TM OX40z

<400>  67

Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
        35                  40                  45              


Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp 
65                  70                  75                  80  


Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His Asp 
        115                 120                 125             


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp Lys 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser Gly 
        195                 200                 205             


Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr Phe 
                245                 250                 255     


Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
    290                 295                 300                 


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
305                 310                 315                 320 


Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
                325                 330                 335     


Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln 
            340                 345                 350         


Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr 
        355                 360                 365             


Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
    370                 375                 380                 


Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe Asp 
385                 390                 395                 400 


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr 
            420                 425                 430         


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile Thr 
        435                 440                 445             


Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln Gln 
    450                 455                 460                 


Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp Arg 
465                 470                 475                 480 


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ala 
                485                 490                 495     


Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr 
            500                 505                 510         


Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe Gly 
        515                 520                 525             


Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr Pro 
    530                 535                 540                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
545                 550                 555                 560 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                565                 570                 575     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Val Ala Ala Ile Leu Gly Leu 
            580                 585                 590         


Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu 
        595                 600                 605             


Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
    610                 615                 620                 


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
625                 630                 635                 640 


Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala 
                645                 650                 655     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            660                 665                 670         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        675                 680                 685             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    690                 695                 700                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
705                 710                 715                 720 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                725                 730                 735     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            740                 745                 750         


His Met Gln Ala Leu Pro Pro Arg 
        755                 760 


<210>  68
<211>  2310
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR D0138 CD22-19 CD8 CD27z

<400>  68
atgctcttgc tcgtgacttc tttgcttttg tgcgaacttc cgcacccagc cttccttttg       60

atacctcagg tacagcttca acaaagcgga ccgggacttg ttaagcattc ccaaaccctt      120

tctctcacgt gtgcaattag cggcgatagt gtatcctcta attctgcggc ctggaactgg      180

atacgacaat caccaagccg gggactcgag tggttgggcc gaacctacta tcggtccaaa      240

tggtataatg actacgcagt atccgtgaaa tctcgcatta cgatcaatcc agacacctcc      300

aaaaatcaat tttctctgca gttgaatagc gtgactcccg aggacacggc cgtttactat      360

tgcgcccagg aagttgaacc ccacgatgca tttgatattt ggggccaggg aaccatggtg      420

acagtgagta gtgggggtgg aggatctgga ggaggcggta gcggcggggg cggcagtgat      480

atccagatga cgcagtcacc ttccagcgtg tatgcgagtg tgggggacaa ggtcaccata      540

acctgtcgcg ctagccaaga tgtcagcggg tggctggctt ggtaccagca gaaaccaggt      600

ttggctcctc agcttttgat ctcaggagcg agcacgcttc agggtgaggt cccaagtcgc      660

tttagtggct ctggctccgg gacagacttc acgttgacga tcagcagttt gcagcctgag      720

gatttcgcga cctactactg ccagcaagcg aaatattttc cgtacacttt cggtcagggg      780

accaaattgg agatcaaagg tgggggtggt tcaggcggcg gaggctcagg cggcggcggt      840

agcggaggag gcggaagcgg gggtggcgga tcagaagtgc aactcgttca gagtggcgcg      900

gaggttaaga aacccggtgc atctgtaaag gttagctgta aggcatcagg atacactttt      960

accagctatt acatgcattg ggtgagacag gctcccggtc aggggctcga atggatgggg     1020

ttgatcaacc cgagtggtgg ttcaacatct tacgcccaga agtttcaggg ccgagtaaca     1080

atgactcggg acacgtctac ctcaactgtg tatatggagc tttccagcct gcgctcagag     1140

gatacagcag tctattactg cgcacggtca gacagaggta taacggccac tgatgcgttc     1200

gatatctggg gacaagggac tatggtaact gtgtcttccg gaggaggagg tagtggaggg     1260

ggaggaagcg gtgggggggg ctcacagtcc gttttgactc agccaccaag cgtctcagtc     1320

gcaccggggc gaatggcgaa aattacttgc ggcgggagcg acataggcaa caagaatgtg     1380

cattggtacc aacagaaacc aggtcaagca cctgttctcg tggtgtatga tgactacgat     1440

cgcccaagcg ggatcccgga gcggttctct ggatcaaatt ctggtgatgc agccactctg     1500

acaatatcaa cggtggaagt cggtgacgag gctgattact tctgccaagt atgggatggc     1560

agcggagatc cctactggat gtttggagga ggtactcaac tgacagttct gggcgcggcc     1620

gcgactacca ctcctgcacc acggccacct accccagccc ccaccattgc aagccagcca     1680

ctttcactgc gccccgaagc gtgtagacca gctgctggag gagccgtgca tacccgaggg     1740

ctggacttcg cctgtgacat ctacatctgg gccccattgg ctggaacttg cggcgtgctg     1800

ctcttgtctc tggtcattac cctgtactgc caacggcgca aataccgctc caataaaggc     1860

gaaagtccgg tagaacccgc agaaccttgc cactacagtt gtcccagaga agaagagggt     1920

tctacaatac ctattcaaga ggactatagg aaaccagagc ccgcatgtag tcccagagtg     1980

aagttcagcc gctcagccga tgcaccggcc taccagcagg gacagaacca gctctacaac     2040

gagctcaacc tgggtcggcg ggaagaatat gacgtgctgg acaaacggcg cggcagagat     2100

ccggagatgg ggggaaagcc gaggaggaag aaccctcaag agggcctgta caacgaactg     2160

cagaaggaca agatggcgga agcctactcc gagatcggca tgaagggaga acgccggaga     2220

gggaagggtc atgacggact gtaccagggc ctgtcaactg ccactaagga cacttacgat     2280

gcgctccata tgcaagcttt gcccccgcgg                                      2310


<210>  69
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0138 CD22-19 CD8 CD27z

<400>  69

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    290                 295                 300                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
305                 310                 315                 320 


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                325                 330                 335     


Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
            340                 345                 350         


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
        355                 360                 365             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe 
385                 390                 395                 400 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
            420                 425                 430         


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile 
        435                 440                 445             


Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln 
    450                 455                 460                 


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp 
465                 470                 475                 480 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp 
                485                 490                 495     


Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp 
            500                 505                 510         


Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe 
        515                 520                 525             


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
    530                 535                 540                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
545                 550                 555                 560 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                565                 570                 575     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            580                 585                 590         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        595                 600                 605             


Tyr Cys Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val 
    610                 615                 620                 


Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly 
625                 630                 635                 640 


Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys 
                645                 650                 655     


Ser Pro Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            660                 665                 670         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        675                 680                 685             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    690                 695                 700                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
705                 710                 715                 720 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                725                 730                 735     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            740                 745                 750         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        755                 760                 765             


Pro 
    


<210>  70
<211>  2280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR D0139 CD22-19 CD28 CD28z

<400>  70
atgctcttgc tcgtgacttc tttgcttttg tgcgaacttc cgcacccagc cttccttttg       60

atacctcagg tacagcttca acaaagcgga ccgggacttg ttaagcattc ccaaaccctt      120

tctctcacgt gtgcaattag cggcgatagt gtatcctcta attctgcggc ctggaactgg      180

atacgacaat caccaagccg gggactcgag tggttgggcc gaacctacta tcggtccaaa      240

tggtataatg actacgcagt atccgtgaaa tctcgcatta cgatcaatcc agacacctcc      300

aaaaatcaat tttctctgca gttgaatagc gtgactcccg aggacacggc cgtttactat      360

tgcgcccagg aagttgaacc ccacgatgca tttgatattt ggggccaggg aaccatggtg      420

acagtgagta gtgggggtgg aggatctgga ggaggcggta gcggcggggg cggcagtgat      480

atccagatga cgcagtcacc ttccagcgtg tatgcgagtg tgggggacaa ggtcaccata      540

acctgtcgcg ctagccaaga tgtcagcggg tggctggctt ggtaccagca gaaaccaggt      600

ttggctcctc agcttttgat ctcaggagcg agcacgcttc agggtgaggt cccaagtcgc      660

tttagtggct ctggctccgg gacagacttc acgttgacga tcagcagttt gcagcctgag      720

gatttcgcga cctactactg ccagcaagcg aaatattttc cgtacacttt cggtcagggg      780

accaaattgg agatcaaagg tgggggtggt tcaggcggcg gaggctcagg cggcggcggt      840

agcggaggag gcggaagcgg gggtggcgga tcagaagtgc aactcgttca gagtggcgcg      900

gaggttaaga aacccggtgc atctgtaaag gttagctgta aggcatcagg atacactttt      960

accagctatt acatgcattg ggtgagacag gctcccggtc aggggctcga atggatgggg     1020

ttgatcaacc cgagtggtgg ttcaacatct tacgcccaga agtttcaggg ccgagtaaca     1080

atgactcggg acacgtctac ctcaactgtg tatatggagc tttccagcct gcgctcagag     1140

gatacagcag tctattactg cgcacggtca gacagaggta taacggccac tgatgcgttc     1200

gatatctggg gacaagggac tatggtaact gtgtcttccg gaggaggagg tagtggaggg     1260

ggaggaagcg gtgggggggg ctcacagtcc gttttgactc agccaccaag cgtctcagtc     1320

gcaccggggc gaatggcgaa aattacttgc ggcgggagcg acataggcaa caagaatgtg     1380

cattggtacc aacagaaacc aggtcaagca cctgttctcg tggtgtatga tgactacgat     1440

cgcccaagcg ggatcccgga gcggttctct ggatcaaatt ctggtgatgc agccactctg     1500

acaatatcaa cggtggaagt cggtgacgag gctgattact tctgccaagt atgggatggc     1560

agcggagatc cctactggat gtttggagga ggtactcaac tgacagttct gggcgcggcc     1620

gcaatcgaag tgatgtatcc acctccgtac ctcgataacg agaaatcaaa tggaacgatc     1680

attcatgtga aagggaaaca tctgtgccca agcccattgt tcccaggtcc gtcaaaacca     1740

ttctgggtgc ttgtcgttgt tgggggtgta ctcgcatgtt attctttgct ggtgactgtg     1800

gcgtttatca tcttctgggt aaggagtaaa cgcagccgcc tgctgcattc agactacatg     1860

aacatgaccc cacggcggcc cggcccaacg cgcaaacact accaacctta cgccccaccg     1920

cgagactttg ccgcctacag atcccgcgtg aagttttccc ggtccgccga cgctccggcg     1980

taccagcagg ggcaaaacca gctgtacaac gaacttaacc tcggtcgccg ggaagaatat     2040

gacgtgctgg acaagcggcg gggaagagat cccgagatgg gtggaaagcc gcggcggaag     2100

aaccctcagg agggcttgta caacgagctg caaaaggaca aaatggccga agcctactcc     2160

gagattggca tgaagggaga gcgcagacgc gggaagggac acgatggact gtaccaggga     2220

ctgtcaaccg cgactaagga cacttacgac gccctgcaca tgcaggccct gcccccgcgc     2280


<210>  71
<211>  760
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0139 CD22-19 CD28 CD28z

<400>  71

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    290                 295                 300                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
305                 310                 315                 320 


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                325                 330                 335     


Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
            340                 345                 350         


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
        355                 360                 365             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe 
385                 390                 395                 400 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
            420                 425                 430         


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile 
        435                 440                 445             


Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln 
    450                 455                 460                 


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp 
465                 470                 475                 480 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp 
                485                 490                 495     


Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp 
            500                 505                 510         


Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe 
        515                 520                 525             


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Ile Glu Val 
    530                 535                 540                 


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
545                 550                 555                 560 


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
                565                 570                 575     


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            580                 585                 590         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        595                 600                 605             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    610                 615                 620                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
625                 630                 635                 640 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
                645                 650                 655     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            660                 665                 670         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        675                 680                 685             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    690                 695                 700                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
705                 710                 715                 720 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                725                 730                 735     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            740                 745                 750         


His Met Gln Ala Leu Pro Pro Arg 
        755                 760 


<210>  72
<211>  2292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR D0145 CD22-19 CD8 OX40z

<400>  72
atgctcttgc tcgtgacttc tttgcttttg tgcgaacttc cgcacccagc cttccttttg       60

atacctcagg tacagcttca acaaagcgga ccgggacttg ttaagcattc ccaaaccctt      120

tctctcacgt gtgcaattag cggcgatagt gtatcctcta attctgcggc ctggaactgg      180

atacgacaat caccaagccg gggactcgag tggttgggcc gaacctacta tcggtccaaa      240

tggtataatg actacgcagt atccgtgaaa tctcgcatta cgatcaatcc agacacctcc      300

aaaaatcaat tttctctgca gttgaatagc gtgactcccg aggacacggc cgtttactat      360

tgcgcccagg aagttgaacc ccacgatgca tttgatattt ggggccaggg aaccatggtg      420

acagtgagta gtgggggtgg aggatctgga ggaggcggta gcggcggggg cggcagtgat      480

atccagatga cgcagtcacc ttccagcgtg tatgcgagtg tgggggacaa ggtcaccata      540

acctgtcgcg ctagccaaga tgtcagcggg tggctggctt ggtaccagca gaaaccaggt      600

ttggctcctc agcttttgat ctcaggagcg agcacgcttc agggtgaggt cccaagtcgc      660

tttagtggct ctggctccgg gacagacttc acgttgacga tcagcagttt gcagcctgag      720

gatttcgcga cctactactg ccagcaagcg aaatattttc cgtacacttt cggtcagggg      780

accaaattgg agatcaaagg tgggggtggt tcaggcggcg gaggctcagg cggcggcggt      840

agcggaggag gcggaagcgg gggtggcgga tcagaagtgc aactcgttca gagtggcgcg      900

gaggttaaga aacccggtgc atctgtaaag gttagctgta aggcatcagg atacactttt      960

accagctatt acatgcattg ggtgagacag gctcccggtc aggggctcga atggatgggg     1020

ttgatcaacc cgagtggtgg ttcaacatct tacgcccaga agtttcaggg ccgagtaaca     1080

atgactcggg acacgtctac ctcaactgtg tatatggagc tttccagcct gcgctcagag     1140

gatacagcag tctattactg cgcacggtca gacagaggta taacggccac tgatgcgttc     1200

gatatctggg gacaagggac tatggtaact gtgtcttccg gaggaggagg tagtggaggg     1260

ggaggaagcg gtgggggggg ctcacagtcc gttttgactc agccaccaag cgtctcagtc     1320

gcaccggggc gaatggcgaa aattacttgc ggcgggagcg acataggcaa caagaatgtg     1380

cattggtacc aacagaaacc aggtcaagca cctgttctcg tggtgtatga tgactacgat     1440

cgcccaagcg ggatcccgga gcggttctct ggatcaaatt ctggtgatgc agccactctg     1500

acaatatcaa cggtggaagt cggtgacgag gctgattact tctgccaagt atgggatggc     1560

agcggagatc cctactggat gtttggagga ggtactcaac tgacagttct gggcgcggcc     1620

gcaacaacca ctccagcacc tagaccgcca acacctgcac ctaccatcgc aagtcaacca     1680

ctttctctca ggcctgaagc gtgccgacct gcagctggtg gggcagtaca taccaggggt     1740

ttggacttcg catgtgacat ctacatctgg gccccattgg ctggaacttg cggcgtgctg     1800

ctcttgtctc tggtcattac cctgtactgc gccttgtacc tgctccgcag agaccaaaga     1860

cttccgcccg acgcccacaa gcccccagga ggaggttcct tcagaacgcc tatacaagaa     1920

gaacaagcag atgcccactc taccctggct aaaatcaggg tgaagtttag ccggtcagct     1980

gatgcacctg catatcagca gggacagaac cagctgtaca atgagctgaa cctcggacga     2040

agagaggagt acgacgtgtt ggacaaaaga cgaggtagag accccgagat gggcggcaag     2100

ccgagaagaa aaaacccaca agaagggctt tataatgagc ttcagaaaga taagatggca     2160

gaggcctaca gtgagattgg catgaagggc gaaagaagga ggggcaaagg acacgacggt     2220

ctctaccaag gcctcagcac ggctaccaaa gatacgtatg acgcattgca tatgcaggca     2280

ttgccgcccc gc                                                         2292


<210>  73
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0145 CD22-19 CD8 OX40z

<400>  73

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    290                 295                 300                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
305                 310                 315                 320 


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                325                 330                 335     


Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
            340                 345                 350         


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
        355                 360                 365             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe 
385                 390                 395                 400 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
            420                 425                 430         


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile 
        435                 440                 445             


Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln 
    450                 455                 460                 


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp 
465                 470                 475                 480 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp 
                485                 490                 495     


Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp 
            500                 505                 510         


Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe 
        515                 520                 525             


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
    530                 535                 540                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
545                 550                 555                 560 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                565                 570                 575     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            580                 585                 590         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        595                 600                 605             


Tyr Cys Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp 
    610                 615                 620                 


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
625                 630                 635                 640 


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe 
                645                 650                 655     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            660                 665                 670         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        675                 680                 685             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    690                 695                 700                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
705                 710                 715                 720 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                725                 730                 735     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            740                 745                 750         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760                 


<210>  74
<211>  2406
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D0140 CD22-19 CD28 CD28 BBz

<400>  74
atgctcttgc tcgtgacttc tttgcttttg tgcgaacttc cgcacccagc cttccttttg       60

atacctcagg tacagcttca acaaagcgga ccgggacttg ttaagcattc ccaaaccctt      120

tctctcacgt gtgcaattag cggcgatagt gtatcctcta attctgcggc ctggaactgg      180

atacgacaat caccaagccg gggactcgag tggttgggcc gaacctacta tcggtccaaa      240

tggtataatg actacgcagt atccgtgaaa tctcgcatta cgatcaatcc agacacctcc      300

aaaaatcaat tttctctgca gttgaatagc gtgactcccg aggacacggc cgtttactat      360

tgcgcccagg aagttgaacc ccacgatgca tttgatattt ggggccaggg aaccatggtg      420

acagtgagta gtgggggtgg aggatctgga ggaggcggta gcggcggggg cggcagtgat      480

atccagatga cgcagtcacc ttccagcgtg tatgcgagtg tgggggacaa ggtcaccata      540

acctgtcgcg ctagccaaga tgtcagcggg tggctggctt ggtaccagca gaaaccaggt      600

ttggctcctc agcttttgat ctcaggagcg agcacgcttc agggtgaggt cccaagtcgc      660

tttagtggct ctggctccgg gacagacttc acgttgacga tcagcagttt gcagcctgag      720

gatttcgcga cctactactg ccagcaagcg aaatattttc cgtacacttt cggtcagggg      780

accaaattgg agatcaaagg tgggggtggt tcaggcggcg gaggctcagg cggcggcggt      840

agcggaggag gcggaagcgg gggtggcgga tcagaagtgc aactcgttca gagtggcgcg      900

gaggttaaga aacccggtgc atctgtaaag gttagctgta aggcatcagg atacactttt      960

accagctatt acatgcattg ggtgagacag gctcccggtc aggggctcga atggatgggg     1020

ttgatcaacc cgagtggtgg ttcaacatct tacgcccaga agtttcaggg ccgagtaaca     1080

atgactcggg acacgtctac ctcaactgtg tatatggagc tttccagcct gcgctcagag     1140

gatacagcag tctattactg cgcacggtca gacagaggta taacggccac tgatgcgttc     1200

gatatctggg gacaagggac tatggtaact gtgtcttccg gaggaggagg tagtggaggg     1260

ggaggaagcg gtgggggggg ctcacagtcc gttttgactc agccaccaag cgtctcagtc     1320

gcaccggggc gaatggcgaa aattacttgc ggcgggagcg acataggcaa caagaatgtg     1380

cattggtacc aacagaaacc aggtcaagca cctgttctcg tggtgtatga tgactacgat     1440

cgcccaagcg ggatcccgga gcggttctct ggatcaaatt ctggtgatgc agccactctg     1500

acaatatcaa cggtggaagt cggtgacgag gctgattact tctgccaagt atgggatggc     1560

agcggagatc cctactggat gtttggagga ggtactcaac tgacagttct gggcgcggcc     1620

gcaatcgaag tgatgtatcc acctccgtac ctcgataacg agaaatcaaa tggaacgatc     1680

attcatgtga aagggaaaca tctgtgccca agcccattgt tcccaggtcc gtcaaaacca     1740

ttctgggtgc ttgtcgttgt tgggggtgta ctcgcatgtt attctttgct ggtgactgtg     1800

gcgtttatca tcttctgggt aaggagtaaa cgcagccgcc tgctgcattc agactacatg     1860

aacatgaccc cacggcggcc cggcccaacg cgcaaacact accaacctta cgccccaccg     1920

cgagactttg ccgcctacag atccaagcgc ggacggaaga aactcttgta catcttcaag     1980

cagccgttca tgcgccctgt gcaaaccacc caagaagagg acgggtgctc ctgccggttc     2040

ccggaagagg aagagggcgg ctgcgaactg cgcgtgaagt tttcccggtc cgccgacgct     2100

ccggcgtacc agcaggggca aaaccagctg tacaacgaac ttaacctcgg tcgccgggaa     2160

gaatatgacg tgctggacaa gcggcgggga agagatcccg agatgggtgg aaagccgcgg     2220

cggaagaacc ctcaggaggg cttgtacaac gagctgcaaa aggacaaaat ggccgaagcc     2280

tactccgaga ttggcatgaa gggagagcgc agacgcggga agggacacga tggactgtac     2340

cagggactgt caaccgcgac taaggacact tacgacgccc tgcacatgca ggccctgccc     2400

ccgcgc                                                                2406


<210>  75
<211>  802
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0140 CD22-19 CD28 CD28 BBz

<400>  75

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    290                 295                 300                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
305                 310                 315                 320 


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                325                 330                 335     


Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
            340                 345                 350         


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
        355                 360                 365             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe 
385                 390                 395                 400 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
            420                 425                 430         


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile 
        435                 440                 445             


Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln 
    450                 455                 460                 


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp 
465                 470                 475                 480 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp 
                485                 490                 495     


Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp 
            500                 505                 510         


Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe 
        515                 520                 525             


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Ile Glu Val 
    530                 535                 540                 


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
545                 550                 555                 560 


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
                565                 570                 575     


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            580                 585                 590         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        595                 600                 605             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    610                 615                 620                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
625                 630                 635                 640 


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu 
                645                 650                 655     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            660                 665                 670         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        675                 680                 685             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    690                 695                 700                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
705                 710                 715                 720 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                725                 730                 735     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            740                 745                 750         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        755                 760                 765             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    770                 775                 780                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
785                 790                 795                 800 


Pro Arg 
        


<210>  76
<211>  2913
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR D0146 CD19 CD8H&TM ICOS z_CD22 CD8H&TM 3z

<400>  76
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctgga gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccagct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggattaatca accctagtgg tggtagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattaccgc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggcggagg aggctccggg ggaggaggtt ccgggggcgg gggttcccag      480

tctgtgctga ctcagccacc ctcggtgtca gtggccccag ggcggatggc caagattacc      540

tgtgggggaa gtgacattgg aaataaaaat gtccactggt atcagcagaa gccaggccag      600

gcccctgtcc tggttgtcta tgatgattac gaccggccct cagggatccc tgagcgattc      660

tctggctcca actctgggga cgcggccacc ctgacgatca gcacggtcga agtcggggat      720

gaggccgact atttctgtca ggtgtgggac ggtagtggtg atccttattg gatgttcggc      780

ggagggaccc agctcaccgt tttaggtgcg gccgcaacga ccactcctgc accacggcca      840

cctaccccag cccccaccat tgcaagccag ccactttcac tgcgccccga agcgtgtaga      900

ccagctgctg gaggagccgt gcatacccga gggctggact tcgcctgtga catctacatc      960

tgggccccat tggctggaac ttgcggcgtg ctgctcttgt ctctggtcat taccctgtac     1020

tgctggctga caaaaaagaa gtattcatct agtgtacatg atccgaacgg tgaatacatg     1080

ttcatgcgcg cggtgaacac ggccaagaag agcagactga ccgacgtaac ccttagagtg     1140

aagtttagcc gctcagccga tgcaccggcc taccagcagg gacagaacca gctctacaac     1200

gagctcaacc tgggtcggcg ggaagaatat gacgtgctgg acaaacggcg cggcagagat     1260

ccggagatgg ggggaaagcc gaggaggaag aaccctcaag agggcctgta caacgaactg     1320

cagaaggaca agatggcgga agcctactcc gagatcggca tgaagggaga acgccggaga     1380

gggaagggtc atgacggact gtaccagggc ctgtcaactg ccactaagga cacttacgat     1440

gcgctccata tgcaagcttt gcccccgcgg cgcgcgaaac gcggcagcgg cgcgaccaac     1500

tttagcctgc tgaaacaggc gggcgatgtg gaagaaaacc cgggcccgcg agcaaagagg     1560

aatattatgg ctctgcctgt tacggcactg ctccttccgc ttgcattgtt gttgcacgca     1620

gcgcggcccc aagtgcagct gcagcagtcc ggtcctggac tggtcaagcc gtcccagact     1680

ctgagcctga cttgcgcaat tagcggggac tcagtctcgt ccaattcggc ggcctggaac     1740

tggatccggc agtcaccatc aaggggcctg gaatggctcg ggcgcactta ctaccggtcc     1800

aaatggtata ccgactacgc cgtgtccgtg aagaatcgga tcaccattaa ccccgacacc     1860

tcgaagaacc agttctcact ccaactgaac agcgtgaccc ccgaggatac cgcggtgtac     1920

tactgcgcac aagaagtgga accgcaggac gccttcgaca tttggggaca gggaacgatg     1980

gtcacagtgt cgtccggtgg aggaggttcc ggaggcggtg gatctggagg cggaggttcg     2040

gatatccaga tgacccagag cccctcctcg gtgtccgcat ccgtgggcga taaggtcacc     2100

attacctgta gagcgtccca ggacgtgtcc ggatggctgg cctggtacca gcagaagcca     2160

ggcttggctc ctcaactgct gatcttcggc gccagcactc ttcaggggga agtgccatca     2220

cgcttctccg gatccggttc cggcaccgac ttcaccctga ccatcagcag cctccagcct     2280

gaggacttcg ccacttacta ctgccaacag gccaagtact tcccctatac cttcggaaga     2340

ggcactaagc tggaaatcaa ggctagcgca accactacgc ctgctccgcg gcctccaacg     2400

cccgcgccca cgatagctag tcagccgttg tctctccgac cagaggcgtg tagaccggcc     2460

gctggcggag ccgtacatac tcgcggactc gacttcgctt gcgacatcta catttgggca     2520

cccttggctg ggacctgtgg ggtgctgttg ctgtccttgg ttattacgtt gtactgcaga     2580

gtcaaatttt ccaggtccgc agatgccccc gcgtaccagc aaggccagaa ccaactttac     2640

aacgaactga acctgggtcg ccgggaggaa tatgatgtgc tggataaacg aagggggagg     2700

gaccctgaga tgggagggaa acctcgcagg aaaaacccgc aggaaggttt gtacaacgag     2760

ttgcagaagg ataagatggc tgaggcttac tctgaaatag ggatgaaggg agagagacgg     2820

agaggaaaag gccatgatgg cctttaccag ggcttaagca cagcaacaaa ggatacttac     2880

gacgctcttc acatgcaagc tctgccacca cgg                                  2913


<210>  77
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0146 CD19 CD8H&TM ICOS z_CD22 CD8H&TMz

<400>  77

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met 
                165                 170                 175     


Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr 
                245                 250                 255     


Trp Met Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val 
            340                 345                 350         


His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala 
        355                 360                 365             


Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Arg Ala Lys Arg Asn Ile Met Ala Leu Pro Val Thr 
        515                 520                 525             


Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln 
    530                 535                 540                 


Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr 
545                 550                 555                 560 


Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser 
                565                 570                 575     


Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp 
            580                 585                 590         


Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Thr Asp Tyr Ala Val 
        595                 600                 605             


Ser Val Lys Asn Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln 
    610                 615                 620                 


Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr 
625                 630                 635                 640 


Tyr Cys Ala Gln Glu Val Glu Pro Gln Asp Ala Phe Asp Ile Trp Gly 
                645                 650                 655     


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
        675                 680                 685             


Ser Ser Val Ser Ala Ser Val Gly Asp Lys Val Thr Ile Thr Cys Arg 
    690                 695                 700                 


Ala Ser Gln Asp Val Ser Gly Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
705                 710                 715                 720 


Gly Leu Ala Pro Gln Leu Leu Ile Phe Gly Ala Ser Thr Leu Gln Gly 
                725                 730                 735     


Glu Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            740                 745                 750         


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
        755                 760                 765             


Gln Gln Ala Lys Tyr Phe Pro Tyr Thr Phe Gly Arg Gly Thr Lys Leu 
    770                 775                 780                 


Glu Ile Lys Ala Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
785                 790                 795                 800 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
                805                 810                 815     


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
            820                 825                 830         


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
        835                 840                 845             


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Val Lys Phe Ser 
    850                 855                 860                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
865                 870                 875                 880 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                885                 890                 895     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            900                 905                 910         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        915                 920                 925             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    930                 935                 940                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
945                 950                 955                 960 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                965                 970     


<210>  78
<211>  2754
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR D0147 CD19 CD8H OX40TM OX40 z_CD22 CD8H&TM z

<400>  78
atgcactggg tgcgacaggc ccctggacaa gggcttgagt ggatgggatt aatcaaccct       60

agtggtggta gcacaagcta cgcacagaag ttccagggca gagtcaccat gaccagggac      120

acgtccacga gcacagtcta catggagctg agcagcctga gatctgagga cacggccgtg      180

tattactgtg cgagatcgga tcggggaatt accgccacgg acgcttttga tatctggggc      240

caagggacaa tggtcaccgt ctcttcaggc ggaggaggct ccgggggagg aggttccggg      300

ggcgggggtt cccagtctgt gctgactcag ccaccctcgg tgtcagtggc cccagggcgg      360

atggccaaga ttacctgtgg gggaagtgac attggaaata aaaatgtcca ctggtatcag      420

cagaagccag gccaggcccc tgtcctggtt gtctatgatg attacgaccg gccctcaggg      480

atccctgagc gattctctgg ctccaactct ggggacgcgg ccaccctgac gatcagcacg      540

gtcgaagtcg gggatgaggc cgactatttc tgtcaggtgt gggacggtag tggtgatcct      600

tattggatgt tcggcggagg gacccagctc accgttttag gtgcggccgc aacgaccact      660

ccagcaccga gaccgccaac ccccgcgcct accatcgcaa gtcaaccact ttctctcagg      720

cctgaagcgt gccgacctgc agctggtggg gcagtacata ccaggggttt ggacttcgca      780

tgtgacgtgg cggcaattct cggcctggga cttgtccttg gtctgcttgg tccgctcgca      840

atacttctgg ccttgtacct gctccgcaga gaccaaagac ttccgcccga cgcccacaag      900

cccccaggag gaggttcctt cagaacgcct atacaagaag aacaagcaga tgcccactct      960

accctggcta aaatcagggt gaagtttagc cgctcagccg atgcaccggc ctaccagcag     1020

ggacagaacc agctctacaa cgagctcaac ctgggtcggc gggaagaata tgacgtgctg     1080

gacaaacggc gcggcagaga tccggagatg gggggaaagc cgaggaggaa gaaccctcaa     1140

gagggcctgt acaacgaact gcagaaggac aagatggcgg aagcctactc cgagatcggc     1200

atgaagggag aacgccggag agggaagggt catgacggac tgtaccaggg cctgtcaact     1260

gccactaagg acacttacga tgcgctccat atgcaagctt tgcccccgcg gcgcgcgaaa     1320

cgcggcagcg gcgcgaccaa ctttagcctg ctgaaacagg cgggcgatgt ggaagaaaac     1380

ccgggcccgc gagcaaagag gaatattatg gctctgcctg ttacggcact gctccttccg     1440

cttgcattgt tgttgcacgc agcgcggccc caagtgcagc tgcagcagtc cggtcctgga     1500

ctggtcaagc cgtcccagac tctgagcctg acttgcgcaa ttagcgggga ctcagtctcg     1560

tccaattcgg cggcctggaa ctggatccgg cagtcaccat caaggggcct ggaatggctc     1620

gggcgcactt actaccggtc caaatggtat accgactacg ccgtgtccgt gaagaatcgg     1680

atcaccatta accccgacac ctcgaagaac cagttctcac tccaactgaa cagcgtgacc     1740

cccgaggata ccgcggtgta ctactgcgca caagaagtgg aaccgcagga cgccttcgac     1800

atttggggac agggaacgat ggtcacagtg tcgtccggtg gaggaggttc cggaggcggt     1860

ggatctggag gcggaggttc ggatatccag atgacccaga gcccctcctc ggtgtccgca     1920

tccgtgggcg ataaggtcac cattacctgt agagcgtccc aggacgtgtc cggatggctg     1980

gcctggtacc agcagaagcc aggcttggct cctcaactgc tgatcttcgg cgccagcact     2040

cttcaggggg aagtgccatc acgcttctcc ggatccggtt ccggcaccga cttcaccctg     2100

accatcagca gcctccagcc tgaggacttc gccacttact actgccaaca ggccaagtac     2160

ttcccctata ccttcggaag aggcactaag ctggaaatca aggctagcgc aaccactacg     2220

cctgctccgc ggcctccaac gcccgcgccc acgatagcta gtcagccgtt gtctctccga     2280

ccagaggcgt gtagaccggc cgctggcgga gccgtacata ctcgcggact cgacttcgct     2340

tgcgacatct acatttgggc acccttggct gggacctgtg gggtgctgtt gctgtccttg     2400

gttattacgt tgtactgcag agtcaaattt tccaggtccg cagatgcccc cgcgtaccag     2460

caaggccaga accaacttta caacgaactg aacctgggtc gccgggagga atatgatgtg     2520

ctggataaac gaagggggag ggaccctgag atgggaggga aacctcgcag gaaaaacccg     2580

caggaaggtt tgtacaacga gttgcagaag gataagatgg ctgaggctta ctctgaaata     2640

gggatgaagg gagagagacg gagaggaaaa ggccatgatg gcctttacca gggcttaagc     2700

acagcaacaa aggatactta cgacgctctt cacatgcaag ctctgccacc acgg           2754


<210>  79
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0147 CD19 CD8H OX40TM OX40 z _CD22 CD8H&TM 3z

<400>  79

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
            20                  25                  30          


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
        35                  40                  45              


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    50                  55                  60                  


Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe Asp Ile Trp Gly 
65                  70                  75                  80  


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro 
            100                 105                 110         


Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile Thr Cys Gly Gly 
        115                 120                 125             


Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln Gln Lys Pro Gly 
    130                 135                 140                 


Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp Arg Pro Ser Gly 
145                 150                 155                 160 


Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ala Ala Thr Leu 
                165                 170                 175     


Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr Phe Cys Gln 
            180                 185                 190         


Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe Gly Gly Gly Thr 
        195                 200                 205             


Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg 
    210                 215                 220                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
225                 230                 235                 240 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                245                 250                 255     


Leu Asp Phe Ala Cys Asp Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
            260                 265                 270         


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
        275                 280                 285             


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
    290                 295                 300                 


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
305                 310                 315                 320 


Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                325                 330                 335     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            340                 345                 350         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        355                 360                 365             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    370                 375                 380                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
385                 390                 395                 400 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                405                 410                 415     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            420                 425                 430         


Ala Leu Pro Pro Arg Arg Ala Lys Arg Gly Ser Gly Ala Thr Asn Phe 
        435                 440                 445             


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Arg 
    450                 455                 460                 


Ala Lys Arg Asn Ile Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
465                 470                 475                 480 


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln 
                485                 490                 495     


Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
            500                 505                 510         


Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp 
        515                 520                 525             


Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr 
    530                 535                 540                 


Tyr Arg Ser Lys Trp Tyr Thr Asp Tyr Ala Val Ser Val Lys Asn Arg 
545                 550                 555                 560 


Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu 
                565                 570                 575     


Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu 
            580                 585                 590         


Val Glu Pro Gln Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
        595                 600                 605             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala 
625                 630                 635                 640 


Ser Val Gly Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
                645                 650                 655     


Ser Gly Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln 
            660                 665                 670         


Leu Leu Ile Phe Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg 
        675                 680                 685             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    690                 695                 700                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr 
705                 710                 715                 720 


Phe Pro Tyr Thr Phe Gly Arg Gly Thr Lys Leu Glu Ile Lys Ala Ser 
                725                 730                 735     


Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            740                 745                 750         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
        755                 760                 765             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
    770                 775                 780                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
785                 790                 795                 800 


Val Ile Thr Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                805                 810                 815     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            820                 825                 830         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        835                 840                 845             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    850                 855                 860                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
865                 870                 875                 880 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                885                 890                 895     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            900                 905                 910         


Gln Ala Leu Pro Pro Arg 
        915             


<210>  80
<211>  3030
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR D0148 CD19 CD8H OX40TM OX40 z_CD22 CD8H&TM ICOS z

<400>  80
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctgga gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccagct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggattaatca accctagtgg tggtagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattaccgc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggcggagg aggctccggg ggaggaggtt ccgggggcgg gggttcccag      480

tctgtgctga ctcagccacc ctcggtgtca gtggccccag ggcggatggc caagattacc      540

tgtgggggaa gtgacattgg aaataaaaat gtccactggt atcagcagaa gccaggccag      600

gcccctgtcc tggttgtcta tgatgattac gaccggccct cagggatccc tgagcgattc      660

tctggctcca actctgggga cgcggccacc ctgacgatca gcacggtcga agtcggggat      720

gaggccgact atttctgtca ggtgtgggac ggtagtggtg atccttattg gatgttcggc      780

ggagggaccc agctcaccgt tttaggtgcg gccgcaacga ccactccagc accgagaccg      840

ccaacccccg cgcctaccat cgcaagtcaa ccactttctc tcaggcctga agcgtgccga      900

cctgcagctg gtggggcagt acataccagg ggtttggact tcgcatgtga cgtggcggca      960

attctcggcc tgggacttgt ccttggtctg cttggtccgc tcgcaatact tctggccttg     1020

tacctgctcc gcagagacca aagacttccg cccgacgccc acaagccccc aggaggaggt     1080

tccttcagaa cgcctataca agaagaacaa gcagatgccc actctaccct ggctaaaatc     1140

agggtgaagt ttagccgctc agccgatgca ccggcctacc agcagggaca gaaccagctc     1200

tacaacgagc tcaacctggg tcggcgggaa gaatatgacg tgctggacaa acggcgcggc     1260

agagatccgg agatgggggg aaagccgagg aggaagaacc ctcaagaggg cctgtacaac     1320

gaactgcaga aggacaagat ggcggaagcc tactccgaga tcggcatgaa gggagaacgc     1380

cggagaggga agggtcatga cggactgtac cagggcctgt caactgccac taaggacact     1440

tacgatgcgc tccatatgca agctttgccc ccgcggcgcg cgaaacgcgg cagcggcgcg     1500

accaacttta gcctgctgaa acaggcgggc gatgtggaag aaaacccggg cccgcgagca     1560

aagaggaata ttatggctct gcctgttacg gcactgctcc ttccgcttgc attgttgttg     1620

cacgcagcgc ggccccaagt gcagctgcag cagtccggtc ctggactggt caagccgtcc     1680

cagactctga gcctgacttg cgcaattagc ggggactcag tctcgtccaa ttcggcggcc     1740

tggaactgga tccggcagtc accatcaagg ggcctggaat ggctcgggcg cacttactac     1800

cggtccaaat ggtataccga ctacgccgtg tccgtgaaga atcggatcac cattaacccc     1860

gacacctcga agaaccagtt ctcactccaa ctgaacagcg tgacccccga ggataccgcg     1920

gtgtactact gcgcacaaga agtggaaccg caggacgcct tcgacatttg gggacaggga     1980

acgatggtca cagtgtcgtc cggtggagga ggttccggag gcggtggatc tggaggcgga     2040

ggttcggata tccagatgac ccagagcccc tcctcggtgt ccgcatccgt gggcgataag     2100

gtcaccatta cctgtagagc gtcccaggac gtgtccggat ggctggcctg gtaccagcag     2160

aagccaggct tggctcctca actgctgatc ttcggcgcca gcactcttca gggggaagtg     2220

ccatcacgct tctccggatc cggttccggc accgacttca ccctgaccat cagcagcctc     2280

cagcctgagg acttcgccac ttactactgc caacaggcca agtacttccc ctataccttc     2340

ggaagaggca ctaagctgga aatcaaggct agcgcaacca ctacgcctgc tccgcggcct     2400

ccaacgcccg cgcccacgat agctagtcag ccgttgtctc tccgaccaga ggcgtgtaga     2460

ccggccgctg gcggagccgt acatactcgc ggactcgact tcgcttgcga catctacatt     2520

tgggcaccct tggctgggac ctgtggggtg ctgttgctgt ccttggttat tacgttgtac     2580

tgctggctga caaaaaagaa gtattcatct agtgtacatg atccgaacgg tgaatacatg     2640

ttcatgcgcg cggtgaacac ggccaagaag agcagactga ccgacgtaac ccttagagtc     2700

aaattttcca ggtccgcaga tgcccccgcg taccagcaag gccagaacca actttacaac     2760

gaactgaacc tgggtcgccg ggaggaatat gatgtgctgg ataaacgaag ggggagggac     2820

cctgagatgg gagggaaacc tcgcaggaaa aacccgcagg aaggtttgta caacgagttg     2880

cagaaggata agatggctga ggcttactct gaaataggga tgaagggaga gagacggaga     2940

ggaaaaggcc atgatggcct ttaccagggc ttgagcacag caacaaagga tacttacgac     3000

gctcttcaca tgcaagctct gccaccacgg                                      3030


<210>  81
<211>  1010
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0148 CD19 CD8H OX40TM OX40 z _CD22 CD8H&TM ICOS z

<400>  81

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met 
                165                 170                 175     


Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr 
                245                 250                 255     


Trp Met Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Val Ala Ala 
305                 310                 315                 320 


Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala Ile 
                325                 330                 335     


Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp 
            340                 345                 350         


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
        355                 360                 365             


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg 
                485                 490                 495     


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
            500                 505                 510         


Glu Glu Asn Pro Gly Pro Arg Ala Lys Arg Asn Ile Met Ala Leu Pro 
        515                 520                 525             


Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg 
    530                 535                 540                 


Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser 
545                 550                 555                 560 


Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser 
                565                 570                 575     


Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu 
            580                 585                 590         


Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Thr Asp Tyr 
        595                 600                 605             


Ala Val Ser Val Lys Asn Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys 
    610                 615                 620                 


Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala 
625                 630                 635                 640 


Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro Gln Asp Ala Phe Asp Ile 
                645                 650                 655     


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        675                 680                 685             


Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Lys Val Thr Ile Thr 
    690                 695                 700                 


Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu Ala Trp Tyr Gln Gln 
705                 710                 715                 720 


Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Phe Gly Ala Ser Thr Leu 
                725                 730                 735     


Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            740                 745                 750         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        755                 760                 765             


Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr Phe Gly Arg Gly Thr 
    770                 775                 780                 


Lys Leu Glu Ile Lys Ala Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro 
785                 790                 795                 800 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                805                 810                 815     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            820                 825                 830         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        835                 840                 845             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Trp Leu Thr 
    850                 855                 860                 


Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met 
865                 870                 875                 880 


Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val 
                885                 890                 895     


Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            900                 905                 910         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        915                 920                 925             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    930                 935                 940                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
945                 950                 955                 960 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                965                 970                 975     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            980                 985                 990         


Thr Ala Thr Lys Asp Thr Tyr Asp  Ala Leu His Met Gln  Ala Leu Pro 
        995                 1000                 1005             


Pro Arg  
    1010 


<210>  82
<211>  2892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR D0149 CD19 CD8H&TM CD27 z_CD22 CD8H&TM ICOS3 z

<400>  82
atgcactggg tgcgacaggc ccctggacaa gggcttgagt ggatgggatt aatcaaccct       60

agtggtggta gcacaagcta cgcacagaag ttccagggca gagtcaccat gaccagggac      120

acgtccacga gcacagtcta catggagctg agcagcctga gatctgagga cacggccgtg      180

tattactgtg cgagatcgga tcggggaatt accgccacgg acgcttttga tatctggggc      240

caagggacaa tggtcaccgt ctcttcaggc ggaggaggct ccgggggagg aggttccggg      300

ggcgggggtt cccagtctgt gctgactcag ccaccctcgg tgtcagtggc cccagggcgg      360

atggccaaga ttacctgtgg gggaagtgac attggaaata aaaatgtcca ctggtatcag      420

cagaagccag gccaggcccc tgtcctggtt gtctatgatg attacgaccg gccctcaggg      480

atccctgagc gattctctgg ctccaactct ggggacgcgg ccaccctgac gatcagcacg      540

gtcgaagtcg gggatgaggc cgactatttc tgtcaggtgt gggacggtag tggtgatcct      600

tattggatgt tcggcggagg gacccagctc accgttttag gtgcggccgc gactaccact      660

cctgcaccac ggccacctac cccagccccc accattgcaa gccagccact ttcactgcgc      720

cccgaagcgt gtagaccagc tgctggagga gccgtgcata cccgagggct ggacttcgcc      780

tgtgacatct acatctgggc cccattggct ggaacttgcg gcgtgctgct cttgtctctg      840

gtcattaccc tgtactgcca acggcgcaaa taccgctcca ataaaggcga aagtccggta      900

gaacccgcag aaccttgcca ctacagttgt cccagagaag aagagggttc tacaatacct      960

attcaagagg actataggaa accagagccc gcatgtagtc ccagagtgaa gttcagccgc     1020

tcagccgatg caccggccta ccagcaggga cagaaccagc tctacaacga gctcaacctg     1080

ggtcggcggg aagaatatga cgtgctggac aaacggcgcg gcagagatcc ggagatgggg     1140

ggaaagccga ggaggaagaa ccctcaagag ggcctgtaca acgaactgca gaaggacaag     1200

atggcggaag cctactccga gatcggcatg aagggagaac gccggagagg gaagggtcat     1260

gacggactgt accagggcct gtcaactgcc actaaggaca cttacgatgc gctccatatg     1320

caagctttgc ccccgcggcg cgcgaaacgc ggcagcggcg cgaccaactt tagcctgctg     1380

aaacaggcgg gcgatgtgga agaaaacccg ggcccgcgag caaagaggaa tattatggct     1440

ctgcctgtta cggcactgct ccttccgctt gcattgttgt tgcacgcagc gcggccccaa     1500

gtgcagctgc agcagtccgg tcctggactg gtcaagccgt cccagactct gagcctgact     1560

tgcgcaatta gcggggactc agtctcgtcc aattcggcgg cctggaactg gatccggcag     1620

tcaccatcaa ggggcctgga atggctcggg cgcacttact accggtccaa atggtatacc     1680

gactacgccg tgtccgtgaa gaatcggatc accattaacc ccgacacctc gaagaaccag     1740

ttctcactcc aactgaacag cgtgaccccc gaggataccg cggtgtacta ctgcgcacaa     1800

gaagtggaac cgcaggacgc cttcgacatt tggggacagg gaacgatggt cacagtgtcg     1860

tccggtggag gaggttccgg aggcggtgga tctggaggcg gaggttcgga tatccagatg     1920

acccagagcc cctcctcggt gtccgcatcc gtgggcgata aggtcaccat tacctgtaga     1980

gcgtcccagg acgtgtccgg atggctggcc tggtaccagc agaagccagg cttggctcct     2040

caactgctga tcttcggcgc cagcactctt cagggggaag tgccatcacg cttctccgga     2100

tccggttccg gcaccgactt caccctgacc atcagcagcc tccagcctga ggacttcgcc     2160

acttactact gccaacaggc caagtacttc ccctatacct tcggaagagg cactaagctg     2220

gaaatcaagg ctagcgcaac cactacgcct gctccgcggc ctccaacgcc cgcgcccacg     2280

atagctagtc agccgttgtc tctccgacca gaggcgtgta gaccggccgc tggcggagcc     2340

gtacatactc gcggactcga cttcgcttgc gacatctaca tttgggcacc cttggctggg     2400

acctgtgggg tgctgttgct gtccttggtt attacgttgt actgctggct gacaaaaaag     2460

aagtattcat ctagtgtaca tgatccgaac ggtgaataca tgttcatgcg cgcggtgaac     2520

acggccaaga agagcagact gaccgacgta acccttagag tcaaattttc caggtccgca     2580

gatgcccccg cgtaccagca aggccagaac caactttaca acgaactgaa cctgggtcgc     2640

cgggaggaat atgatgtgct ggataaacga agggggaggg accctgagat gggagggaaa     2700

cctcgcagga aaaacccgca ggaaggtttg tacaacgagt tgcagaagga taagatggct     2760

gaggcttact ctgaaatagg gatgaaggga gagagacgga gaggaaaagg ccatgatggc     2820

ctttaccagg gcttgagcac agcaacaaag gatacttacg acgctcttca catgcaagct     2880

ctgccaccac gg                                                         2892


<210>  83
<211>  964
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR D0149 CD19 CD8H&TM ICOS z CD22 CD8H&TM ICOS z

<400>  83

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
            20                  25                  30          


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
        35                  40                  45              


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    50                  55                  60                  


Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe Asp Ile Trp Gly 
65                  70                  75                  80  


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro 
            100                 105                 110         


Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile Thr Cys Gly Gly 
        115                 120                 125             


Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln Gln Lys Pro Gly 
    130                 135                 140                 


Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp Arg Pro Ser Gly 
145                 150                 155                 160 


Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ala Ala Thr Leu 
                165                 170                 175     


Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr Phe Cys Gln 
            180                 185                 190         


Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe Gly Gly Gly Thr 
        195                 200                 205             


Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg 
    210                 215                 220                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
225                 230                 235                 240 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                245                 250                 255     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            260                 265                 270         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Gln Arg 
        275                 280                 285             


Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu 
    290                 295                 300                 


Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro 
305                 310                 315                 320 


Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro Arg Val 
                325                 330                 335     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            340                 345                 350         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        355                 360                 365             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    370                 375                 380                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
385                 390                 395                 400 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                405                 410                 415     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            420                 425                 430         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala 
        435                 440                 445             


Lys Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
    450                 455                 460                 


Asp Val Glu Glu Asn Pro Gly Pro Arg Ala Lys Arg Asn Ile Met Ala 
465                 470                 475                 480 


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
                485                 490                 495     


Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys 
            500                 505                 510         


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val 
        515                 520                 525             


Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg 
    530                 535                 540                 


Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Thr 
545                 550                 555                 560 


Asp Tyr Ala Val Ser Val Lys Asn Arg Ile Thr Ile Asn Pro Asp Thr 
                565                 570                 575     


Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp 
            580                 585                 590         


Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro Gln Asp Ala Phe 
        595                 600                 605             


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
625                 630                 635                 640 


Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Lys Val Thr 
                645                 650                 655     


Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu Ala Trp Tyr 
            660                 665                 670         


Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Phe Gly Ala Ser 
        675                 680                 685             


Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    690                 695                 700                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
705                 710                 715                 720 


Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr Phe Gly Arg 
                725                 730                 735     


Gly Thr Lys Leu Glu Ile Lys Ala Ser Ala Thr Thr Thr Pro Ala Pro 
            740                 745                 750         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        755                 760                 765             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    770                 775                 780                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
785                 790                 795                 800 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Trp 
                805                 810                 815     


Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu 
            820                 825                 830         


Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr 
        835                 840                 845             


Asp Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    850                 855                 860                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
865                 870                 875                 880 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                885                 890                 895     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            900                 905                 910         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        915                 920                 925             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    930                 935                 940                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
945                 950                 955                 960 


Leu Pro Pro Arg 
                


