                               SEQUENCE LISTING

<110> ALNYLAM PHARMACEUTICALS, INC.
 
<120> TRANSTHYRETIN (TTR) IRNA COMPOSITIONS AND METHODS OF USE THEREOF 
      FOR TREATING OR PREVENTING TTR-ASSOCIATED OCULAR DISEASES

<130> 121301-09320

<140>
<141>

<150> 62/844,174
<151> 2019-05-07

<150> 62/738,256
<151> 2018-09-28

<160> 103   

<170> PatentIn version 3.5

<210> 1
<211> 938
<212> DNA
<213> Homo sapiens

<400> 1
gttgactaag tcaataatca gaatcagcag gtttgcagtc agattggcag ggataagcag       60

cctagctcag gagaagtgag tataaaagcc ccaggctggg agcagccatc acagaagtcc      120

actcattctt ggcaggatgg cttctcatcg tctgctcctc ctctgccttg ctggactggt      180

atttgtgtct gaggctggcc ctacgggcac cggtgaatcc aagtgtcctc tgatggtcaa      240

agttctagat gctgtccgag gcagtcctgc catcaatgtg gccgtgcatg tgttcagaaa      300

ggctgctgat gacacctggg agccatttgc ctctgggaaa accagtgagt ctggagagct      360

gcatgggctc acaactgagg aggaatttgt agaagggata tacaaagtgg aaatagacac      420

caaatcttac tggaaggcac ttggcatctc cccattccat gagcatgcag aggtggtatt      480

cacagccaac gactccggcc cccgccgcta caccattgcc gccctgctga gcccctactc      540

ctattccacc acggctgtcg tcaccaatcc caaggaatga gggacttctc ctccagtgga      600

cctgaaggac gagggatggg atttcatgta accaagagta ttccattttt actaaagcag      660

tgttttcacc tcatatgcta tgttagaagt ccaggcagag acaataaaac attcctgtga      720

aaggcacttt tcattccact ttaacttgat tttttaaatt cccttattgt cccttccaaa      780

aaaaagagaa tcaaaatttt acaaagaatc aaaggaattc tagaaagtat ctgggcagaa      840

cgctaggaga gatccaaatt tccattgtct tgcaagcaaa gcacgtatta aatatgatct      900

gcagccatta aaaagacaca ttctgtaaaa aaaaaaaa                              938


<210> 2

<400> 2
000


<210> 3

<400> 3
000


<210> 4
<211> 23
<212> DNA
<213> Homo sapiens

<400> 4
gatgggattt catgtaacca aga                                               23


<210> 5
<211> 650
<212> DNA
<213> Homo sapiens

<400> 5
acagaagtcc actcattctt ggcaggatgg cttctcatcg tctgctcctc ctctgccttg       60

ctggactggt atttgtgtct gaggctggcc ctacgggcac cggtgaatcc aagtgtcctc      120

tgatggtcaa agttctagat gctgtccgag gcagtcctgc catcaatgtg gccgtgcatg      180

tgttcagaaa ggctgctgat gacacctggg agccatttgc ctctgggaaa accagtgagt      240

ctggagagct gcatgggctc acaactgagg aggaatttgt agaagggata tacaaagtgg      300

aaatagacac caaatcttac tggaaggcac ttggcatctc cccattccat gagcatgcag      360

aggtggtatt cacagccaac gactccggcc cccgccgcta caccattgcc gccctgctga      420

gcccctactc ctattccacc acggctgtcg tcaccaatcc caaggaatga gggacttctc      480

ctccagtgga cctgaaggac gagggatggg atttcatgta accaagagta ttccattttt      540

actaaagcag tgttttcacc tcatatgcta tgttagaagt ccaggcagag acaataaaac      600

attcctgtga aaggcacttt tcattccaaa aaaaaaaaaa aaaaaaaaaa                 650


<210> 6

<400> 6
000


<210> 7
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 7
ucuugguuac augaaauccc auc                                               23


<210> 8

<400> 8
000


<210> 9

<400> 9
000


<210> 10
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
ugggauuuca uguaaccaag a                                                 21


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 11
tgggatttca tgtaaccaag a                                                 21


<210> 12
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
ugggauuuca uguaaccaag a                                                 21


<210> 13
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
ucuugguuac augaaauccc auc                                               23


<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Gly Arg Gly Asp Ser Pro Lys Cys 
1               5               


<210> 15
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 15
ugggauuuca uguaaccaag a                                                 21


<210> 16
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 16
ucuugguuac augaaauccc auc                                               23


<210> 17
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 17
ucuugguuac augaaauccc auc                                               23


<210> 18
<211> 29
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      GALA peptide"

<400> 18
Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  


<210> 19
<211> 30
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      EALA peptide"

<400> 19
Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu Ala Leu Ala Glu Ala Leu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  30  


<210> 20
<211> 15
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      endosomolytic/fusogenic peptide"

<400> 20
Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15  


<210> 21
<211> 22
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      INF-7 peptide"

<400> 21
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Trp Asp Tyr Gly 
            20          


<210> 22
<211> 23
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      InfHA-2 peptide"

<400> 22
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210> 23
<211> 48
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      diINF-7 peptide"

<400> 23
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly 
            20                  25                  30          


Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly Cys 
        35                  40                  45              


<210> 24
<211> 44
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      diINF-3 peptide"

<400> 24
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile 
            20                  25                  30          


Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Gly Cys 
        35                  40                  


<210> 25
<211> 35
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      GLF peptide"

<400> 25
Gly Leu Phe Gly Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu 
1               5                   10                  15      


His Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly 
            20                  25                  30          


Gly Ser Cys 
        35  


<210> 26
<211> 34
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      GALA-INF3 peptide"

<400> 26
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly Gly 
            20                  25                  30          


Ser Cys 
        


<210> 27
<211> 41
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      INF-5 peptide"


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Norleucine 

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Norleucine 

<400> 27
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Xaa Ile Asp Gly Lys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu 
            20                  25                  30          


Asn Gly Trp Glu Gly Xaa Ile Asp Gly 
        35                  40      


<210> 28
<211> 19
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      JTS-1 peptide"

<400> 28
Leu Phe Glu Ala Leu Leu Glu Leu Leu Glu Ser Leu Trp Glu Leu Leu 
1               5                   10                  15      


Leu Glu Ala 
            


<210> 29
<211> 20
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      ppTG1 peptide"

<400> 29
Gly Leu Phe Lys Ala Leu Leu Lys Leu Leu Lys Ser Leu Trp Lys Leu 
1               5                   10                  15      


Leu Leu Lys Ala 
            20  


<210> 30
<211> 20
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      ppTG20 peptide"

<400> 30
Gly Leu Phe Arg Ala Leu Leu Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Leu Arg Ala 
            20  


<210> 31
<211> 30
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      KALA peptide"

<400> 31
Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210> 32
<211> 22
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      HA peptide"

<400> 32
Gly Leu Phe Phe Glu Ala Ile Ala Glu Phe Ile Glu Gly Gly Trp Glu 
1               5                   10                  15      


Gly Leu Ile Glu Gly Cys 
            20          


<210> 33
<211> 26
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Melittin peptide"

<400> 33
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210> 34
<211> 8
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      endosomolytic/fusogenic peptide"

<400> 34
His His His His His Trp Tyr Gly 
1               5               


<210> 35
<211> 10
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      endosomolytic/fusogenic peptide"

<400> 35
Cys His Lys Lys Lys Lys Lys Lys His Cys 
1               5                   10  


<210> 36
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 36
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 37
<211> 14
<212> PRT
<213> Human immunodeficiency virus

<400> 37
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Cys 
1               5                   10                  


<210> 38
<211> 27
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      signal sequence based peptide"

<400> 38
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 39
<211> 18
<212> PRT
<213> Mus sp.

<400> 39
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210> 40
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210> 41
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 43
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Lys Phe Phe Lys Phe Phe Lys Phe Phe Lys 
1               5                   10  


<210> 44
<211> 37
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      LL-37 peptide"

<400> 44
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210> 45
<211> 31
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cecropin P1 peptide"

<400> 45
Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210> 46
<211> 30
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      alpha-defensin peptide"

<400> 46
Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210> 47
<211> 36
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      beta-defensin peptide"

<400> 47
Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
1               5                   10                  15      


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
            20                  25                  30          


Lys Cys Cys Lys 
        35      


<210> 48
<211> 42
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      PR-39 peptide"

<400> 48
Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Pro 
1               5                   10                  15      


Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro Gly Phe Pro Pro 
            20                  25                  30          


Arg Phe Pro Pro Arg Phe Pro Gly Lys Arg 
        35                  40          


<210> 49
<211> 13
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      indolicidin peptide"

<400> 49
Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210> 50
<211> 16
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      RFGF peptide"

<400> 50
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 51
<211> 11
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      RFGF analogue peptide"

<400> 51
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 52
<211> 12
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      bactenecin peptide"

<400> 52
Arg Lys Cys Arg Ile Val Val Ile Arg Val Cys Arg 
1               5                   10          


<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 53
caguguucuu gcucuauaat t                                                 21


<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 54
uuauagagca agaacacugt t                                                 21


<210> 55
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 55
aacaguguuc uugcucuaua att                                               23


<210> 56
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 56
uuauagagca agaacacugu uuu                                               23


<210> 57
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 57
uuauagagca agaacacugu uuu                                               23


<210> 58
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 58
aacaguguuc uugcucuaua a                                                 21


<210> 59
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 59
ugggauuuca uguaaccaag att                                               23


<210> 60
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 60
ugggauuuca uguaaccaag a                                                 21


<210> 61
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 61
ugggauuuca uguaaccaag a                                                 21


<210> 62
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 62
ucuugguuac augaaauccc auc                                               23


<210> 63
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 63
caguguucuu gcucuauaa                                                    19


<210> 64
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 64
uuauagagca agaacacug                                                    19


<210> 65
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 65
aacaguguuc uugcucuaua a                                                 21


<210> 66
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 66
uuauagagca agaacacugu uuu                                               23


<210> 67
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 67
augggauuuc auguaaccaa a                                                 21


<210> 68
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 68
uuucauguaa ccaagaguau u                                                 21


<210> 69
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 69
uguaaccaag aguauuccau u                                                 21


<210> 70
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 70
aaccaagagu auuccauuuu u                                                 21


<210> 71
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 71
uuuuuacuaa agcaguguuu u                                                 21


<210> 72
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 72
uuacuaaagc aguguuuuca a                                                 21


<210> 73
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 73
cuaaagcagu guuuucaccu a                                                 21


<210> 74
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 74
ggcagagaca auaaaacauu a                                                 21


<210> 75
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 75
cagagacaau aaaacauucc u                                                 21


<210> 76
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 76
caauaaaaca uuccugugaa a                                                 21


<210> 77
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 77
uuugguuaca ugaaauccca ucc                                               23


<210> 78
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 78
aauacucuug guuacaugaa auc                                               23


<210> 79
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 79
aauggaauac ucuugguuac aug                                               23


<210> 80
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 80
aaaaauggaa uacucuuggu uac                                               23


<210> 81
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 81
aaaacacugc uuuaguaaaa aug                                               23


<210> 82
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 82
uugaaaacac ugcuuuagua aaa                                               23


<210> 83
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 83
uaggugaaaa cacugcuuua gua                                               23


<210> 84
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 84
uaauguuuua uugucucugc cug                                               23


<210> 85
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 85
aggaauguuu uauugucucu gcc                                               23


<210> 86
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 86
uuucacagga auguuuuauu guc                                               23


<210> 87
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 87
aacaguguuc uugcucuaua a                                                 21


<210> 88
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 88
aacaguguuc uugcucuaua a                                                 21


<210> 89
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 89
aacaguguuc uugcucuaua a                                                 21


<210> 90
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 90
aacaguguuc uugcucuaua a                                                 21


<210> 91
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 91
aacaguguuc uugcucuaua a                                                 21


<210> 92
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 92
aacaguguuc uugcucuaua a                                                 21


<210> 93
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 93
aacaguguuc uugcucuaua a                                                 21


<210> 94
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 94
aacaguguuc uugcucuaua a                                                 21


<210> 95
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 95
aacaguguuc uugcucuaua a                                                 21


<210> 96
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 96
aacaguguuc uugcucuaua a                                                 21


<210> 97
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 97
aacaguguuc uugcucuaua a                                                 21


<210> 98
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 98
uuauagagca agaacacugu uuu                                               23


<210> 99
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 99
uuauagagca agaacacugu uuu                                               23


<210> 100
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 100
uuauagagca agaacacugu uuu                                               23


<210> 101
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 101
uuauagagca agaacacugu uuu                                               23


<210> 102
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 102
ucuuggtuac augaaauccc auc                                               23


<210> 103
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 103
ugggauuuca uguaaccaag a                                                 21


