                         SEQUENCE LISTING

<110>  Drappa, Jorn
       Abulescu, Marius
       Li, Jing
       Grant, Ethan
       Streicher, Katie
       Illei, Gabor
       Wang, Liangwei
       Rees, William
 
<120>  CD40L ANTAGONIST AND USES THEREOF

<130>  054493-510001WO

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile Thr 
1               5                   10                  15      


Trp Ser Asp Asp Phe Gly Glu Tyr Val Trp Cys Glu Leu Thr Tyr Gly 
            20                  25                  30          


Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Asp Leu Trp Tyr His 
        35                  40                  45              


His Ala His Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu 
    50                  55                  60                  


Val Ser Leu Ile Cys Arg Ser Gly Asp Met Ser Ser Asn Pro Ala Lys 
65                  70                  75                  80  


Glu Thr Phe Thr Thr Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Gly Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp 
            100                 105                 110         


Val Thr Asp Thr Thr Ala Leu Ile Thr Trp Ser Asp Asp Phe Gly Glu 
        115                 120                 125             


Tyr Val Trp Cys Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp 
    130                 135                 140                 


Arg Thr Thr Ile Asp Leu Trp Tyr His His Ala His Tyr Ser Ile Gly 
145                 150                 155                 160 


Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Cys Arg Ser 
                165                 170                 175     


Gly Asp Met Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Gly Gly Gly Asp Ala His Lys Ser Glu Val Ala 
        195                 200                 205             


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
    210                 215                 220                 


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val 
225                 230                 235                 240 


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
                245                 250                 255     


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
            260                 265                 270         


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
        275                 280                 285             


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
    290                 295                 300                 


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
305                 310                 315                 320 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
                325                 330                 335     


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
            340                 345                 350         


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
        355                 360                 365             


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
    370                 375                 380                 


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
385                 390                 395                 400 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
                405                 410                 415     


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
            420                 425                 430         


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
        435                 440                 445             


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
    450                 455                 460                 


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
465                 470                 475                 480 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
                485                 490                 495     


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
            500                 505                 510         


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
        515                 520                 525             


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
    530                 535                 540                 


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
545                 550                 555                 560 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
                565                 570                 575     


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
            580                 585                 590         


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
        595                 600                 605             


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
    610                 615                 620                 


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
625                 630                 635                 640 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
                645                 650                 655     


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
            660                 665                 670         


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
        675                 680                 685             


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
    690                 695                 700                 


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
705                 710                 715                 720 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
                725                 730                 735     


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
            740                 745                 750         


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
        755                 760                 765             


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
    770                 775                 780                 


Leu 
785 


<210>  2
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile Thr Trp Ser 
1               5                   10                  15      


Asp Asp Phe Gly Glu Tyr Val Trp Cys Glu Leu Thr Tyr Gly Ile Lys 
            20                  25                  30          


Asp Val Pro Gly Asp Arg Thr Thr Ile Asp Leu Trp Tyr His His Ala 
        35                  40                  45              


His Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser 
    50                  55                  60                  


Leu Ile Cys Arg Arg Gly Asp Met Ser Ser Asn Pro Ala Lys Glu Thr 
65                  70                  75                  80  


Phe Thr Thr 
            


<210>  3
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile Thr Trp Ser 
1               5                   10                  15      


Asp Asp Phe Gly Glu Tyr Val Trp Cys Glu Leu Thr Tyr Gly Ile Lys 
            20                  25                  30          


Asp Val Pro Gly Asp Arg Thr Thr Ile Asp Leu Trp Tyr His His Ala 
        35                  40                  45              


His Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser 
    50                  55                  60                  


Leu Ile Cys Arg Ser Gly Asp Met Ser Ser Asn Pro Ala Lys Glu Thr 
65                  70                  75                  80  


Phe Thr Thr 
            


<210>  4
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile Thr 
1               5                   10                  15      


Trp Ser Asp Asp Phe Gly Glu Tyr Val Trp Cys Glu Leu Thr Tyr Gly 
            20                  25                  30          


Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Asp Leu Trp Tyr His 
        35                  40                  45              


His Ala His Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu 
    50                  55                  60                  


Val Ser Leu Ile Cys Arg Ser Gly Asp Met Ser Ser Asn Pro Ala Lys 
65                  70                  75                  80  


Glu Thr Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp 
            100                 105                 110         


Val Thr Asp Thr Thr Ala Leu Ile Thr Trp Ser Asp Asp Phe Gly Glu 
        115                 120                 125             


Tyr Val Trp Cys Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp 
    130                 135                 140                 


Arg Thr Thr Ile Asp Leu Trp Tyr His His Ala His Tyr Ser Ile Gly 
145                 150                 155                 160 


Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Cys Arg Ser 
                165                 170                 175     


Gly Asp Met Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr 
            180                 185                 190 


<210>  5
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5

Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile Thr Trp Ser 
1               5                   10                  15      


Asp Glu Phe Gly His Tyr Asp Gly Cys Glu Leu Thr Tyr Gly Ile Lys 
            20                  25                  30          


Asp Val Pro Gly Asp Arg Thr Thr Ile Asp Leu Trp Trp His Ser Ala 
        35                  40                  45              


Trp Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser 
    50                  55                  60                  


Leu Ile Cys Arg Arg Gly Asp Met Ser Ser Asn Pro Ala Lys Glu Thr 
65                  70                  75                  80  


Phe Thr Thr 
            


<210>  6
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile Thr 
1               5                   10                  15      


Trp Ser Asp Glu Phe Gly His Tyr Asp Gly Cys Glu Leu Thr Tyr Gly 
            20                  25                  30          


Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Asp Leu Trp Trp His 
        35                  40                  45              


Ser Ala Trp Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu 
    50                  55                  60                  


Val Ser Leu Ile Cys Tyr Thr Asp Gln Glu Ala Gly Asn Pro Ala Lys 
65                  70                  75                  80  


Glu Thr Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp 
            100                 105                 110         


Val Thr Asp Thr Thr Ala Leu Ile Thr Trp Ser Asp Glu Phe Gly His 
        115                 120                 125             


Tyr Asp Gly Cys Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp 
    130                 135                 140                 


Arg Thr Thr Ile Asp Leu Trp Trp His Ser Ala Trp Tyr Ser Ile Gly 
145                 150                 155                 160 


Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Cys Tyr Thr 
                165                 170                 175     


Asp Gln Glu Ala Gly Asn Pro Ala Lys Glu Thr Phe Thr Thr 
            180                 185                 190 


