                         SEQUENCE LISTING

<110>  THE GENERAL HOSPITAL CORPORATION
 
<120>  TREATMENT OF AGING-ASSOCIATED CONDITIONS BY DNA DEGRADATION

<130>  B1195.70086WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/736,138
<151>  2018-09-25

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  1938
<212>  DNA
<213>  Homo sapiens

<400>  1
agtcctggcc tctgatgtaa cccagcgccc cgcagtcccg acacagattc ctggatctca       60

gccccatagc agctatgatc ccgctgctgc tggcagcgct gctgtgcgtc cccgccgggg      120

ccctgacctg ctacggggac tccgggcagc ctgtagactg gttcgtggtc tacaagctgc      180

cagctcttag agggtccggg gaggcggcgc agagagggct gcagtacaag tatctggacg      240

agagctccgg aggctggcgg gacggcaggg cactcatcaa cagcccggag ggggccgtgg      300

gccgaagcct gcagccgctg taccggagca acaccagcca gctcgccttc ctgctctaca      360

atgaccaacc gcctcaaccc agcaaggctc aggactcttc catgcgtggg cacacgaagg      420

gtgtcctgct ccttgaccac gatgggggct tctggctggt ccacagtgta cctaacttcc      480

ctccaccggc ctcctctgct gcatacagct ggcctcatag cgcctgtacc tacgggcaga      540

ccctgctctg tgtgtctttt cccttcgctc agttctcgaa gatgggcaag cagctgacct      600

acacctaccc ctgggtctat aactaccagc tggaagggat ctttgcccag gaattccccg      660

acttggagaa tgtggtcaag ggccaccacg ttagccaaga accctggaac agcagcatca      720

cactcacatc ccaggccggg gctgttttcc agagctttgc caagttcagc aaatttggag      780

atgacctgta ctccggctgg ttggcagcag cccttggtac caacctgcag gtccagttct      840

ggcacaaaac tgtaggcatc ctgccctcta actgctcgga tatctggcag gttctgaatg      900

tgaaccagat agctttccct ggaccagccg gcccaagctt caacagcaca gaggaccact      960

ccaaatggtg cgtgtcccca aaagggccct ggacctgcgt gggtgacatg aatcggaacc     1020

agggagagga gcaacggggt gggggcacac tgtgtgccca gctgccagcc ctctggaaag     1080

ccttccagcc gctggtgaag aactaccagc cctgtaatgg catggccagg aagcccagca     1140

gagcttataa gatctaaccc ttatggccag gtgcagtggc tcacgtatgt aatcccagca     1200

ctttgggaag ccaaggaggg aggatcactt gaactcagga attcgagacc agcctgggct     1260

acatagtgag accacatctc tactagaact taaaaaaagt tagccaggca cggtgataaa     1320

tgcctgtagt cccagccact gaagccagag gatcgattga accagggaga tcatggtcac     1380

agtgaactat gattacgcca acctgggtca catagcaaga ctctgtttca aaaaaaaagg     1440

gggggcgggg gacgggtggg tgcagtggct cacatctgta accccagcac tttgggaggc     1500

tgagatgggc agatcacttg aggtcaggag ttcgagacca gcctggccaa catggtgaaa     1560

ccccatatcc attaaaaata tttaaaaatt agccagacat ggtggcacgc gtctgtggtc     1620

ctagctcctc gggaggctga ggcaggagaa tcgcttgaac tcgggaggca gaggttgtca     1680

tgagctgagc taacaccacg gcacttcagc ctgggtgaca gaatgagact ctgtgtcaaa     1740

aaaataaaaa ataaaaaatc taagggctca ggaaccagtt tggacttgat tttgaatccc     1800

agttcatccc cttcctagct gtatgacctt gattgtgtgc cttaaccgct ctgtgacaca     1860

gtctacctgt ctgcaaaatg ggaaacataa tacctgccat caggattgtt gaggagtaaa     1920

taaatggaaa ttggtgga                                                   1938


<210>  2
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ile Pro Leu Leu Leu Ala Ala Leu Leu Cys Val Pro Ala Gly Ala 
1               5                   10                  15      


Leu Thr Cys Tyr Gly Asp Ser Gly Gln Pro Val Asp Trp Phe Val Val 
            20                  25                  30          


Tyr Lys Leu Pro Ala Leu Arg Gly Ser Gly Glu Ala Ala Gln Arg Gly 
        35                  40                  45              


Leu Gln Tyr Lys Tyr Leu Asp Glu Ser Ser Gly Gly Trp Arg Asp Gly 
    50                  55                  60                  


Arg Ala Leu Ile Asn Ser Pro Glu Gly Ala Val Gly Arg Ser Leu Gln 
65                  70                  75                  80  


Pro Leu Tyr Arg Ser Asn Thr Ser Gln Leu Ala Phe Leu Leu Tyr Asn 
                85                  90                  95      


Asp Gln Pro Pro Gln Pro Ser Lys Ala Gln Asp Ser Ser Met Arg Gly 
            100                 105                 110         


His Thr Lys Gly Val Leu Leu Leu Asp His Asp Gly Gly Phe Trp Leu 
        115                 120                 125             


Val His Ser Val Pro Asn Phe Pro Pro Pro Ala Ser Ser Ala Ala Tyr 
    130                 135                 140                 


Ser Trp Pro His Ser Ala Cys Thr Tyr Gly Gln Thr Leu Leu Cys Val 
145                 150                 155                 160 


Ser Phe Pro Phe Ala Gln Phe Ser Lys Met Gly Lys Gln Leu Thr Tyr 
                165                 170                 175     


Thr Tyr Pro Trp Val Tyr Asn Tyr Gln Leu Glu Gly Ile Phe Ala Gln 
            180                 185                 190         


Glu Phe Pro Asp Leu Glu Asn Val Val Lys Gly His His Val Ser Gln 
        195                 200                 205             


Glu Pro Trp Asn Ser Ser Ile Thr Leu Thr Ser Gln Ala Gly Ala Val 
    210                 215                 220                 


Phe Gln Ser Phe Ala Lys Phe Ser Lys Phe Gly Asp Asp Leu Tyr Ser 
225                 230                 235                 240 


Gly Trp Leu Ala Ala Ala Leu Gly Thr Asn Leu Gln Val Gln Phe Trp 
                245                 250                 255     


His Lys Thr Val Gly Ile Leu Pro Ser Asn Cys Ser Asp Ile Trp Gln 
            260                 265                 270         


Val Leu Asn Val Asn Gln Ile Ala Phe Pro Gly Pro Ala Gly Pro Ser 
        275                 280                 285             


Phe Asn Ser Thr Glu Asp His Ser Lys Trp Cys Val Ser Pro Lys Gly 
    290                 295                 300                 


Pro Trp Thr Cys Val Gly Asp Met Asn Arg Asn Gln Gly Glu Glu Gln 
305                 310                 315                 320 


Arg Gly Gly Gly Thr Leu Cys Ala Gln Leu Pro Ala Leu Trp Lys Ala 
                325                 330                 335     


Phe Gln Pro Leu Val Lys Asn Tyr Gln Pro Cys Asn Gly Met Ala Arg 
            340                 345                 350         


Lys Pro Ser Arg Ala Tyr Lys Ile 
        355                 360 


<210>  3
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  3
aaagatgtgc ttcgagatgt gt                                                22


<210>  4
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  4
cactttgtca gttaccaacg tca                                               23


<210>  5
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  5
ccatgcaggt gagcttcgt                                                    19


<210>  6
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6
gaatctgcga gagacaccat c                                                 21


<210>  7
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  7
tgcccagact acgacttgtg                                                   20


<210>  8
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  8
agtgtccgtg tttcaccttc c                                                 21


<210>  9
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  9
tggattcgac ttagacttga cct                                               23


<210>  10
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  10
tggcggtgtc ataatgtctt tc                                                22


<210>  11
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  11
taaccctggc tttggaatca aaa                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  12
tgggtacaag gtaaaatggc ttt                                               23


<210>  13
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  13
ggtcaccgct ccaaatatgt ag                                                22


<210>  14
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  14
cagtagtcca agttcgtgcg a                                                 21


<210>  15
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  15
agcggcagag ttaggtgaaa                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  16
tgagtgcctt cttgatgtgc                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  17
gtttccgaag tggacatcgc a                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  18
ctgcacaggt tgttctcagc                                                   20


<210>  19
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  19
ttgatgacga tgaaatgcct ga                                                22


<210>  20
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  20
caggtcacca gactcctcac                                                   20


<210>  21
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  21
aaattcggta catcctcgac gg                                                22


<210>  22
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  22
ggaaggttca ggttgttttc tgc                                               23


<210>  23
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  23
ccaagtgctg ccgtcatttt c                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  24
ggctcgcagg gatgatttca a                                                 21


<210>  25
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  25
tcgccttcct gctctacaat                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  26
cccatcttcg agaactgagc                                                   20


<210>  27
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  27
gtggtgctgt cgctcttgat a                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  28
ccccagaaaa tggttcacgc t                                                 21


<210>  29
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  29
ttctgcttgt catccccttt                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  30
cttctgccat gcctgtatca                                                   20


<210>  31
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  31
cgagcaaggt ccttccatag t                                                 21


<210>  32
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  32
ggtgtcggga ttccgatgac                                                   20


<210>  33
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  33
agtcttccaa tcctactgtt gct                                               23


<210>  34
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  34
tccccgtcac ctccaatcc                                                    19


<210>  35
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  35
tgctctgcct atcctctgag t                                                 21


<210>  36
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  36
tcacatcctt ttcgaggttg tag                                               23


<210>  37
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  37
actgagaggc tccgagaaat g                                                 21


<210>  38
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  38
gaaccccgca tcttggctt                                                    19


<210>  39
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  39
gggttttcgt ggttcacatc c                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  40
ctagacgctg gctcctcagt a                                                 21


<210>  41
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  41
tgtccgtcag aacccatgc                                                    19


<210>  42
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  42
aaagtcgaag ttccatcgct c                                                 21


<210>  43
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  43
ctccgtggcc ttagctgtg                                                    19


<210>  44
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  44
tttggagtac gctggatagc ct                                                22


<210>  45
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  45
acaactttgg tatcgtggaa gg                                                22


<210>  46
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  46
gccatcacgc cacagtttc                                                    19


<210>  47
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  47
gaactctttc ggtcgtaccc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  48
cgaatctgca ccgtagttga                                                   20


<210>  49
<211>  19
<212>  DNA
<213>  Mus musculus

<400>  49
cctggtgatg tccgacctg                                                    19


<210>  50
<211>  19
<212>  DNA
<213>  Mus musculus

<400>  50
ccatgagcgc atcgcaatc                                                    19


<210>  51
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  51
tctacgcagt gcttctttgc c                                                 21


<210>  52
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  52
aagggggatc ttcagcttta gta                                               23


<210>  53
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  53
gcgcccagac agaagtcata g                                                 21


<210>  54
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  54
agccttgcct ttgttcagta tc                                                22


<210>  55
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  55
ccagcttcaa atctcacagc ag                                                22


<210>  56
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  56
cttctttggg tattgcttgg gatc                                              24


<210>  57
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  57
tcgagaccat ttactgcaac ag                                                22


<210>  58
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  58
cattgccggt ggaaattcct t                                                 21


<210>  59
<211>  19
<212>  DNA
<213>  Mus musculus

<400>  59
gctcagctgg ggactctac                                                    19


<210>  60
<211>  19
<212>  DNA
<213>  Mus musculus

<400>  60
ggtctggccg aaggtttga                                                    19


<210>  61
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  61
aggtcggtgt gaacggattt g                                                 21


<210>  62
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  62
tgtagaccat gtagttgagg tca                                               23


