                         SEQUENCE LISTING

<110> PENDULUM THERAPEUTICS, INC.
 
<120> MICROBIAL COMPOSITIONS AND METHODS OF USE

<130> 46790-734.601

<140> PCT/US2019/052694
<141> 2019-09-24

<150> 62/735,747
<151> 2018-09-24

<150> 62/801,983
<151> 2019-02-06

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1523
<212>  DNA
<213>  akkermansia muciniphila

<400>  1
aaaattaatt tgatggagag tttgattctg gctcagaacg aacgctggcg gcgtggataa       60

gacatgcaag tcgaacgaga gaattgctag cttgctaata attctctagt ggcgcacggg      120

tgagtaacac gtgagtaacc tgcccccgag agcgggatag ccctgggaaa ctgggattaa      180

taccgcatag tatcgaaaga ttaaagcagc aatgcgcttg gggatgggct cgcggcctat      240

tagttagttg gtgaggtaac ggctcaccaa ggcgatgacg ggtagccggt ctgagaggat      300

gtccggccac actggaactg agacacggtc cagacaccta cgggtggcag cagtcgagaa      360

tcattcacaa tgggggaaac cctgatggtg tgacgccgcg tgggggaatg aaggtcttcg      420

gattgtaaac ccctgtcatg tgggagcaaa ttaaaaagat agtaccacaa gaggaagaga      480

cggctaactc tgtgccagca gccgcggtaa tacagaggtc tcaagcgttg ttcggaatca      540

ctgggcgtaa agcgtgcgta ggctgtttcg taagtcgtgt gtgaaaggcg cgggctcaac      600

ccgcggacgg cacatgatac tgcgagacta gagtaatgga gggggaaccg gaattctcgg      660

tgtagcagtg aaatgcgtag atatcgagag gaacactcgt ggcgaaggcg ggttcctgga      720

cattaactga cgctgaggca cgaaggccag gggagcgaaa gggattagat acccctgtag      780

tcctggcagt aaacggtgca cgcttggtgt gcggggaatc gaccccctgc gtgccggagc      840

taacgcgtta agcgtgccgc ctggggagta cggtcgcaag attaaaactc aaagaaattg      900

acggggaccc gcacaagcgg tggagtatgt ggcttaattc gatgcaacgc gaagaacctt      960

acctgggctt gacatgtaat gaacaacatg tgaaagcatg cgactcttcg gaggcgttac     1020

acaggtgctg catggccgtc gtcagctcgt gtcgtgagat gtttggttaa gtccagcaac     1080

gagcgcaacc cctgttgcca gttaccagca cgtgaaggtg gggactctgg cgagactgcc     1140

cagatcaact gggaggaagg tggggacgac gtcaggtcag tatggccctt atgcccaggg     1200

ctgcacacgt actacaatgc ccagtacaga gggggccgaa gccgcgaggc ggaggaaatc     1260

ctgaaaactg ggcccagttc ggactgtagg ctgcaacccg cctacacgaa gccggaatcg     1320

ctagtaatgg cgcatcagct acggcgccgt gaatacgttc ccgggtcttg tacacaccgc     1380

ccgtcacatc atggaagccg gtcgcacccg aagtatctga agccaaccgc aaggaggcag     1440

ggtcctaagg tgagactggt aactgggatg aagtcgtaac aaggtagccg taggggaacc     1500

tgcggctgga tcacctcctt tct                                             1523


<210>  2
<211>  1507
<212>  DNA
<213>  akkermansia muciniphila

<400>  2
agagtttgat tctggctcag aacgaacgct ggcggcgtgg ataagacatg caagtcgaac       60

gagagaattg ctagcttgct aataattctc tagtggcgca cgggtgagta acacgtgagt      120

aacctgcccc cgagagcggg atagccctgg gaaactggga ttaataccgc atagtatcgc      180

aagattaaag cagcaatgcg cttggggatg ggctcgcggc ctattagtta gttggtgagg      240

taacggctca ccaaggcgat gacgggtagc cggtctgaga ggatgtccgg ccacactgga      300

actgagacac ggtccagaca cctacgggtg gcagcagtcg agaatcattc acaatggggg      360

aaaccctgat ggtgcgacgc cgcgtggggg aatgaaggtc ttcggattgt aaacccctgt      420

catgtgggag caaattaaaa agatagtacc acaagaggaa gagacggcta actctgtgcc      480

agcagccgcg gtaatacaga ggtctcaagc gttgttcgga atcactgggc gtaaagcgtg      540

cgtaggctgt ttcgtaagtc gtgtgtgaaa ggcgcgggct caacccgcgg acggcacatg      600

atactgcgag actagagtaa tggaggggga accggaattc tcggtgtagc agtgaaatgc      660

gtagatatcg agaggaacac tcgtggcgaa ggcgggttcc tggacattaa ctgacgctga      720

ggcacgaagg ccaggggagc gaaagggatt agatacccct gtagtcctgg cagtaaacgg      780

tgcacgcttg gtgtgcgggg aatcgacccc ctgcgtgccg gagctaacgc gttaagcgtg      840

ccgcctgggg agtacggtcg caagattaaa actcaaagaa attgacgggg acccgcacaa      900

gcggtggagt atgtggctta attcgatgca acgcgaagaa ccttacctgg gcttgacatg      960

taatgaacaa catgtgaaag catgcgactc ttcggaggcg ttacacaggt gctgcatggc     1020

cgtcgtcagc tcgtgtcgtg agatgtttgg ttaagtccag caacgagcgc aacccctgtt     1080

gccagttacc agcacgtgaa ggtggggact ctggcgagac tgcccagatc aactgggagg     1140

aaggtgggga cgacgtcagg tcagtatggc ccttatgccc agggctgcac acgtactaca     1200

atgcccagta cagagggggc cgaagccgcg aggcggagga aatcctaaaa actgggccca     1260

gttcggactg taggctgcaa cccgcctaca cgaagccgga atcgctagta atggcgcatc     1320

agctacggcg ccgtgaatac gttcccgggt cttgtacaca ccgcccgtca catcatggaa     1380

gccggtcgca cccgaagtat ctgaagccaa ccgcaaggag gcagggtcct aaggtgagac     1440

tggtaactgg gatgaagtcg taacaaggta gccgtagggg aacctgcggc tggatcacct     1500

cctttct                                                               1507


<210>  3
<211>  1504
<212>  DNA
<213>  akkermansia muciniphila

<400>  3
ctggcggcgt ggataagaca tgcaagtcga acgagagaat tgctagcttg ctaataattc       60

tctagtggcg cacgggtgag taacacgtga gtaacctgcc cccgagagcg ggatagccct      120

gggaaactgg gattaatacc gcatagtatc gaaagattaa agcagcaatg cgcttgggga      180

tgggctcgcg gcctattagt tagttggtga ggtaacggct caccaaggcg atgacgggta      240

gccggtctga gaggatgtcc ggccacactg gaactgagac acggtccaga cacctacggg      300

tggcagcagt cgagaatcat tcacaatggg ggaaaccctg atggtgcgac gccgcgtggg      360

ggaatgaagg tcttcggatt gtaaacccct gtcatgtggg agcaaattaa aaagatagta      420

ccacaagagg aagagacggc taactctgtg ccagcagccg cggtaataca gaggtctcaa      480

gcgttgttcg gaatcactgg gcgtaaagcg tgcgtaggct gtttcgtaag tcgtgtgtga      540

aaggcgcggg ctcaacccgc ggacggcaca tgatactgcg agactagagt aatggagggg      600

gaaccggaat tctcggtgta gcagtgaaat gcgtagatat cgagaggaac actcgtggcg      660

aaggcgggtt cctggacatt aactgacgct gaggcacgaa ggccagggga gcgaaaggga      720

ttagataccc ctgtagtcct ggcagtaaac ggtgcacgct tggtgtgcgg ggaatcgacc      780

ccctgcgtgc cggagctaac gcgttaagcg tgccgcctgg ggagtacggt cgcaagatta      840

aaactcaaag aaattgacgg ggacccgcac aagcggtgga gtatgtggct taattcgatg      900

caacgcgaag aaccttacct gggcttgaca tgtaatgaac aacatgtgaa agcatgcgac      960

tcttcggagg cgttacacag gtgctgcatg gccgtcgtca gctcgtgtcg tgagatgttt     1020

ggttaagtcc agcaacgagc gcaacccctg ttgccagtta ccagcacgtg aaggtgggga     1080

ctctggcgag actgcccaga tcaactggga ggaaggtggg gacgacgtca ggtcagtatg     1140

gcccttatgc ccagggctgc acacgtacta caatgcccag tacagagggg gccgaagccg     1200

cgaggcggag gaaatcctaa aaactgggcc cagttcggac tgtaggctgc aacccgccta     1260

cacgaagccg gaatcgctag taatggcgca tcagctacgg cgccgtgaat acgttcccgg     1320

gtcttgtaca caccgcccgt cacatcatgg aagccggtcg cacccgaagt atctgaagcc     1380

aaccgcaagg aggcagggtc ctaaggtgag actggtaact gggatgaagt cgtaacaagg     1440

tagccgtagg ggaacctgcg gctggatcac ctcctttcta tggagcaagt gcacggaagt     1500

gcac                                                                  1504


<210>  4
<211>  1438
<212>  DNA
<213>  akkermansia muciniphila

<400>  4
tgctagcttg ctaataattc tctagtggcg cacgggtgag taacacgtga gtaacctgcc       60

cccgagagcg ggatagccct gggaaactgg gattaatacc gcatagtatc gcaagattaa      120

agcagcaatg cgcttgggga tgggctcgcg gcctattagt tagttggtga ggtaacggct      180

caccaaggcg atgacgggta gccggtctga gaggatgtcc ggccacactg gaactgagac      240

acggtccaga cacctacggg tggcagcagt cgagaatcat tcacaatggg ggaaaccctg      300

atggtgcgac gccgcgtggg ggaatgaagg tcttcggatt gtaaacccct gtcatgtggg      360

agcaaattaa aaagatagta ccacaagagg aagagacggc taactctgtg ccagcagccg      420

cggtaataca gaggtctcaa gcgttgttcg gaatcactgg gcgtaaagcg tgcgtaggct      480

gtttcgtaag tcgtgtgtga aaggcgcggg ctcaacccgc ggacggcaca tgatactgcg      540

agactagagt aatggagggg gaaccggaat tctcggtgta gcagtgaaat gcgtagatat      600

cgagaggaac actcgtggcg aaggcgggtt cctggacatt aactgacgct gaggcacgaa      660

ggccagggga gcgaaaggga ttagataccc ctgtagtcct ggcagtaaac ggtgcacgct      720

tggtgtgcgg ggaatcgacc ccctgcgtgc cggagctaac gcgttaagcg tgccgcctgg      780

ggagtacggt cgcaagatta aaactcaaag aaattgacgg ggacccgcac aagcggtgga      840

gtatgtggct taattcgatg caacgcgaag aaccttacct gggcttgaca tgtaatgaac      900

aacatgtgaa agcatgcgac tcttcggagg cgttacacag gtgctgcatg gccgtcgtca      960

gctcgtgtcg tgagatgttt ggttaagtcc agcaacgagc gcaacccctg ttgccagtta     1020

ccagcacgtg aaggtgggga ctctggcgag actgcccaga tcaactggga ggaaggtggg     1080

gacgacgtca ggtcagtatg gcccttatgc ccagggctgc acacgtacta caatgcccag     1140

tacagagggg gccgaagccg cgaggcggag gaaatcctaa aaactgggcc cagttcggac     1200

tgtaggctgc aacccgccta cacgaagccg gaatcgctag taatggcgca tcagctacgg     1260

cgccgtgaat acgttcccgg gtcttgtaca caccgcccgt cacatcatgg aagccggtcg     1320

cacccgaagt atctgaagcc aaccgcaagg aggcagggtc ctaaggtgag actggtaact     1380

gggatgaagt cgtaacaagg tagccgtagg ggaacctgcg gctggatcac ctcctttc       1438


<210>  5
<211>  1554
<212>  DNA
<213>  akkermansia muciniphila


<220>
<221>  misc_feature
<222>  (1537)..(1542)
<223>  n is a, c, g, or t

<400>  5
tccagcaatt tcaaaaatta atttgatgga gagtttgatt ctggctcaga acgaacgctg       60

gcggcgtgga taagacatgc aagtcgaacg agagaattgc tagcttgcta ataattctct      120

agtggcgcac gggtgagtaa cacgtgagta acctgccccc gagagcggga tagccctggg      180

aaactgggat taataccgca tagtatcgca agattaaagc agcaatgcgc ttggggatgg      240

gctcgcggcc tattagttag ttggtgaggt aacggctcac caaggcgatg acgggtagcc      300

ggtctgagag gatgtccggc cacactggaa ctgagacacg gtccagacac ctacgggtgg      360

cagcagtcga gaatcattca caatggggga aaccctgatg gtgcgacgcc gcgtggggga      420

atgaaggtct tcggattgta aacccctgtc atgtgggagc aaattaaaaa gatagtacca      480

caagaggaag agacggctaa ctctgtgcca gcagccgcgg taatacagag gtctcaagcg      540

ttgttcggaa tcactgggcg taaagcgtgc gtaggctgtt tcgtaagtcg tgtgtgaaag      600

gcgcgggctc aacccgcgga cggcacatga tactgcgaga ctagagtaat ggagggggaa      660

ccggaattct cggtgtagca gtgaaatgcg tagatatcga gaggaacact cgtggcgaag      720

gcgggttcct ggacattaac tgacgctgag gcacgaaggc caggggagcg aaagggatta      780

gatacccctg tagtcctggc agtaaacggt gcacgcttgg tgtgcgggga atcgaccccc      840

tgcgtgccgg agctaacgcg ttaagcgtgc cgcctgggga gtacggtcgc aagattaaaa      900

ctcaaagaaa ttgacgggga cccgcacaag cggtggagta tgtggcttaa ttcgatgcaa      960

cgcgaagaac cttacctggg cttgacatgt aatgaacaac atgtgaaagc atgcgactct     1020

tcggaggcgt tacacaggtg ctgcatggcc gtcgtcagct cgtgtcgtga gatgtttggt     1080

taagtccagc aacgagcgca acccctgttg ccagttacca gcacgtgaag gtggggactc     1140

tggcgagact gcccagatca actgggagga aggtggggac gacgtcaggt cagtatggcc     1200

cttatgccca gggctgcaca cgtactacaa tgcccagtac agagggggcc gaagccgcga     1260

ggcggaggaa atcctaaaaa ctgggcccag ttcggactgt aggctgcaac ccgcctacac     1320

gaagccggaa tcgctagtaa tggcgcatca gctacggcgc cgtgaatacg ttcccgggtc     1380

ttgtacacac cgcccgtcac atcatggaag ccggtcgcac ccgaagtatc tgaagccaac     1440

cgcaaggagg cagggtccta aggtgagact ggtaactggg atgaagtcgt aacaaggtag     1500

ccgtagggga acctgcggct ggatcacctc ctttctnnnn nnatggagca agta           1554


<210>  6
<211>  1507
<212>  DNA
<213>  akkermansia muciniphila

<400>  6
gagtttgatt ctggctcaga acgaacgctg gcggcgtgga taagacatgc aagtcgaacg       60

agagaattgc tagcttgcta ataattctct agtggcgcac gggtgagtaa cacgtgagta      120

acctgccccc gagagcggga tagccctggg aaactgggat taataccgca tagtatcgaa      180

agattaaagc agcaatgcgc ttggggatgg gctcgcggcc tattagttag ttggtgaggt      240

aacggctcac caaggcgatg acgggtagcc ggtctgagag gatgtccggc cacactggaa      300

ctgagacacg gtccagacac ctacgggtgg cagcagtcga gaatcattca caatggggga      360

aaccctgatg gtgtgacgcc gcgtggggga atgaaggtct tcggattgta aacccctgtc      420

atgtgggagc aaattaaaaa gatagtacca caagaggaag agacggctaa ctctgtgcca      480

gcagccgcgg taatacagag gtctcaagcg ttgttcggaa tcactgggcg taaagcgtgc      540

gtaggctgtt tcgtaagtcg tgtgtgaaag gcgcgggctc aacccgcgga cggcacatga      600

tactgcgaga ctagagtaat ggagggggaa ccggaattct cggtgtagca gtgaaatgcg      660

tagatatcga gaggaacact cgtggcgaag gcgggttcct ggacattaac tgacgctgag      720

gcacgaaggc caggggagcg aaagggatta gatacccctg tagtcctggc agtaaacggt      780

gcacgcttgg tgtgcgggga atcgaccccc tgcgtgccgg agctaacgcg ttaagcgtgc      840

cgcctgggga gtacggtcgc aagattaaaa ctcaaagaaa ttgacgggga cccgcacaag      900

cggtggagta tgtggcttaa ttcgatgcaa cgcgaagaac cttacctggg cttgacatgt      960

aatgaacaac atgtgaaagc atgcgactct tcggaggcgt tacacaggtg ctgcatggcc     1020

gtcgtcagct cgtgtcgtga gatgtttggt taagtccagc aacgagcgca acccctgttg     1080

ccagttacca gcacgtgaag gtggggactc tggcgagact gcccagatca actgggagga     1140

aggtggggac gacgtcaggt cagtatggcc cttatgccca gggctgcaca cgtactacaa     1200

tgcccagtac agagggggcc gaagccgcga ggcggaggaa atcctgaaaa ctgggcccag     1260

ttcggactgt aggctgcaac ccgcctacac gaagccggaa tcgctagtaa tggcgcatca     1320

gctacggcgc cgtgaatacg ttcccgggtc ttgtacacac cgcccgtcac atcatggaag     1380

ccggtcgcac ccgaagtatc tgaagccaac cgcaaggagg cagggtccta aggtgagact     1440

ggtaactggg atgaagtcgt aacaaggtag ccgtagggga acctgcggct ggatcacctc     1500

ctttcta                                                               1507


