                         SEQUENCE LISTING

<110>  National University of Singapore
       Wang, Shu
       Zha, Shijun
 
<120>  Engineered human mesenchymal stromal cells with low 
       immunogenicity, methods and kits of generating the same.

<130>  2019.P01734

<150>  SG 10201808423W
<151>  2018-09-26

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  7361
<212>  DNA
<213>  Homo sapiens

<400>  1
attcctgaag ctgacagcat tcgggccgag atgtctcgct ccgtggcctt agctgtgctc       60

gcgctactct ctctttctgg cctggaggct atccagcgtg agtctctcct accctcccgc      120

tctggtcctt cctctcccgc tctgcaccct ctgtggccct cgctgtgctc tctcgctccg      180

tgacttccct tctccaagtt ctccttggtg gcccgccgtg gggctagtcc agggctggat      240

ctcggggaag cggcggggtg gcctgggagt ggggaagggg gtgcgcaccc gggacgcgcg      300

ctacttgccc ctttcggcgg ggagcagggg agacctttgg cctacggcga cgggagggtc      360

gggacaaagt ttagggcgtc gataagcgtc agagcgccga ggttggggga gggtttctct      420

tccgctcttt cgcggggcct ctggctcccc cagcgcagct ggagtggggg acgggtaggc      480

tcgtcccaaa ggcgcggcgc tgaggtttgt gaacgcgtgg aggggcgctt ggggtctggg      540

ggaggcgtcg cccgggtaag cctgtctgct gcggctctgc ttcccttaga ctggagagct      600

gtggacttcg tctaggcgcc cgctaagttc gcatgtccta gcacctctgg gtctatgtgg      660

ggccacaccg tggggaggaa acagcacgcg acgtttgtag aatgcttggc tgtgatacaa      720

agcggtttcg aataattaac ttatttgttc ccatcacatg tcacttttaa aaaattataa      780

gaactacccg ttattgacat ctttctgtgt gccaaggact ttatgtgctt tgcgtcattt      840

aattttgaaa acagttatct tccgccatag ataactacta tggttatctt ctgcctctca      900

cagatgaaga aactaaggca ccgagatttt aagaaactta attacacagg ggataaatgg      960

cagcaatcga gattgaagtc aagcctaacc agggcttttg cgggagcgca tgccttttgg     1020

ctgtaattcg tgcatttttt tttaagaaaa acgcctgcct tctgcgtgag attctccaga     1080

gcaaactggg cggcatgggc cctgtggtct tttcgtacag agggcttcct ctttggctct     1140

ttgcctggtt gtttccaaga tgtactgtgc ctcttacttt cggttttgaa aacatgaggg     1200

ggttgggcgt ggtagcttac gcctgtaatc ccagcactta gggaggccga ggcgggagga     1260

tggcttgagg tccgtagttg agaccagcct ggccaacatg gtgaagcctg gtctctacaa     1320

aaaataataa caaaaattag ccgggtgtgg tggctcgtgc ctgtggtccc agctgctccg     1380

gtggctgagg cgggaggatc tcttgagctt aggcttttga gctatcatgg cgccagtgca     1440

ctccagcgtg ggcaacagag cgagaccctg tctctcaaaa aagaaaaaaa aaaaaaaaga     1500

aagagaaaag aaaagaaaga aagaagtgaa ggtttgtcag tcaggggagc tgtaaaacca     1560

ttaataaaga taatccaaga tggttaccaa gactgttgag gacgccagag atcttgagca     1620

ctttctaagt acctggcaat acactaagcg cgctcacctt ttcctctggc aaaacatgat     1680

cgaaagcaga atgttttgat catgagaaaa ttgcatttaa tttgaataca atttatttac     1740

aacataaagg ataatgtata tatcaccacc attactggta tttgctggtt atgttagatg     1800

tcattttaaa aaataacaat ctgatattta aaaaaaaatc ttattttgaa aatttccaaa     1860

gtaatacatg ccatgcatag accatttctg gaagatacca caagaaacat gtaatgatga     1920

ttgcctctga aggtctattt tcctcctctg acctgtgtgt gggttttgtt tttgttttac     1980

tgtgggcata aattaatttt tcagttaagt tttggaagct taaataactc tccaaaagtc     2040

ataaagccag taactggttg agcccaaatt caaacccagc ctgtctgata cttgtcctct     2100

tcttagaaaa gattacagtg atgctctcac aaaatcttgc cgccttccct caaacagaga     2160

gttccaggca ggatgaatct gtgctctgat ccctgaggca tttaatatgt tcttattatt     2220

agaagctcag atgcaaagag ctctcttagc ttttaatgtt atgaaaaaaa tcaggtcttc     2280

attagattcc ccaatccacc tcttgatggg gctagtagcc tttccttaat gatagggtgt     2340

ttctagagag atatatctgg tcaaggtggc ctggtactcc tccttctccc cacagcctcc     2400

cagacaagga ggagtagctg ccttttagtg atcatgtacc ctgaatataa gtgtatttaa     2460

aagaatttta tacacatata tttagtgtca atctgtatat ttagtagcac taacacttct     2520

cttcattttc aatgaaaaat atagagttta taatattttc ttcccacttc cccatggatg     2580

gtctagtcat gcctctcatt ttggaaagta ctgtttctga aacattaggc aatatattcc     2640

caacctggct agtttacagc aatcacctgt ggatgctaat taaaacgcaa atcccactgt     2700

cacatgcatt actccatttg atcataatgg aaagtatgtt ctgtcccatt tgccatagtc     2760

ctcacctatc cctgttgtat tttatcgggt ccaactcaac catttaaggt atttgccagc     2820

tcttgtatgc atttaggttt tgtttctttg ttttttagct catgaaatta ggtacaaagt     2880

cagagagggg tctggcatat aaaacctcag cagaaataaa gaggttttgt tgtttggtaa     2940

gaacatacct tgggttggtt gggcacggtg gctcgtgcct gtaatcccaa cactttggga     3000

ggccaaggca ggctgatcac ttgaagttgg gagttcaaga ccagcctggc caacatggtg     3060

aaatcccgtc tctactgaaa atacaaaaat taaccaggca tggtggtgtg tgcctgtagt     3120

cccaggaatc acttgaaccc aggaggcgga ggttgcagtg agctgagatc tcaccactgc     3180

acactgcact ccagcctggg caatggaatg agattccatc ccaaaaaata aaaaaataaa     3240

aaaataaaga acataccttg ggttgatcca cttaggaacc tcagataata acatctgcca     3300

cgtatagagc aattgctatg tcccaggcac tctactagac acttcataca gtttagaaaa     3360

tcagatgggt gtagatcaag gcaggagcag gaaccaaaaa gaaaggcata aacataagaa     3420

aaaaaatgga aggggtggaa acagagtaca ataacatgag taatttgatg ggggctatta     3480

tgaactgaga aatgaacttt gaaaagtatc ttggggccaa atcatgtaga ctcttgagtg     3540

atgtgttaag gaatgctatg agtgctgaga gggcatcaga agtccttgag agcctccaga     3600

gaaaggctct taaaaatgca gcgcaatctc cagtgacaga agatactgct agaaatctgc     3660

tagaaaaaaa acaaaaaagg catgtataga ggaattatga gggaaagata ccaagtcacg     3720

gtttattctt caaaatggag gtggcttgtt gggaaggtgg aagctcattt ggccagagtg     3780

gaaatggaat tgggagaaat cgatgaccaa atgtaaacac ttggtgcctg atatagcttg     3840

acaccaagtt agccccaagt gaaataccct ggcaatatta atgtgtcttt tcccgatatt     3900

cctcaggtac tccaaagatt caggtttact cacgtcatcc agcagagaat ggaaagtcaa     3960

atttcctgaa ttgctatgtg tctgggtttc atccatccga cattgaagtt gacttactga     4020

agaatggaga gagaattgaa aaagtggagc attcagactt gtctttcagc aaggactggt     4080

ctttctatct cttgtactac actgaattca cccccactga aaaagatgag tatgcctgcc     4140

gtgtgaacca tgtgactttg tcacagccca agatagttaa gtggggtaag tcttacattc     4200

ttttgtaagc tgctgaaagt tgtgtatgag tagtcatatc ataaagctgc tttgatataa     4260

aaaaggtcta tggccatact accctgaatg agtcccatcc catctgatat aaacaatctg     4320

catattggga ttgtcaggga atgttcttaa agatcagatt agtggcacct gctgagatac     4380

tgatgcacag catggtttct gaaccagtag tttccctgca gttgagcagg gagcagcagc     4440

agcacttgca caaatacata tacactctta acacttctta cctactggct tcctctagct     4500

tttgtggcag cttcaggtat atttagcact gaacgaacat ctcaagaagg tataggcctt     4560

tgtttgtaag tcctgctgtc ctagcatcct ataatcctgg acttctccag tactttctgg     4620

ctggattggt atctgaggct agtaggaagg gcttgttcct gctgggtagc tctaaacaat     4680

gtattcatgg gtaggaacag cagcctattc tgccagcctt atttctaacc attttagaca     4740

tttgttagta catggtattt taaaagtaaa acttaatgtc ttcctttttt ttctccactg     4800

tctttttcat agatcgagac atgtaagcag catcatggag gtaagttttt gaccttgaga     4860

aaatgttttt gtttcactgt cctgaggact atttatagac agctctaaca tgataaccct     4920

cactatgtgg agaacattga cagagtaaca ttttagcagg gaaagaagaa tcctacaggg     4980

tcatgttccc ttctcctgtg gagtggcatg aagaaggtgt atggccccag gtatggccat     5040

attactgacc ctctacagag agggcaaagg aactgccagt atggtattgc aggataaagg     5100

caggtggtta cccacattac ctgcaaggct ttgatctttc ttctgccatt tccacattgg     5160

acatctctgc tgaggagaga aaatgaacca ctcttttcct ttgtataatg ttgttttatt     5220

cttcagacag aagagaggag ttatacagct ctgcagacat cccattcctg tatggggact     5280

gtgtttgcct cttagaggtt cccaggccac tagaggagat aaagggaaac agattgttat     5340

aacttgatat aatgatacta taatagatgt aactacaagg agctccagaa gcaagagaga     5400

gggaggaact tggacttctc tgcatcttta gttggagtcc aaaggctttt caatgaaatt     5460

ctactgccca gggtacattg atgctgaaac cccattcaaa tctcctgtta tattctagaa     5520

cagggaattg atttgggaga gcatcaggaa ggtggatgat ctgcccagtc acactgttag     5580

taaattgtag agccaggacc tgaactctaa tatagtcatg tgttacttaa tgacggggac     5640

atgttctgag aaatgcttac acaaacctag gtgttgtagc ctactacacg cataggctac     5700

atggtatagc ctattgctcc tagactacaa acctgtacag cctgttactg tactgaatac     5760

tgtgggcagt tgtaacacaa tggtaagtat ttgtgtatct aaacatagaa gttgcagtaa     5820

aaatatgcta ttttaatctt atgagaccac tgtcatatat acagtccatc attgaccaaa     5880

acatcatatc agcatttttt cttctaagat tttgggagca ccaaagggat acactaacag     5940

gatatactct ttataatggg tttggagaac tgtctgcagc tacttctttt aaaaaggtga     6000

tctacacagt agaaattaga caagtttggt aatgagatct gcaatccaaa taaaataaat     6060

tcattgctaa cctttttctt ttcttttcag gtttgaagat gccgcatttg gattggatga     6120

attccaaatt ctgcttgctt gctttttaat attgatatgc ttatacactt acactttatg     6180

cacaaaatgt agggttataa taatgttaac atggacatga tcttctttat aattctactt     6240

tgagtgctgt ctccatgttt gatgtatctg agcaggttgc tccacaggta gctctaggag     6300

ggctggcaac ttagaggtgg ggagcagaga attctcttat ccaacatcaa catcttggtc     6360

agatttgaac tcttcaatct cttgcactca aagcttgtta agatagttaa gcgtgcataa     6420

gttaacttcc aatttacata ctctgcttag aatttggggg aaaatttaga aatataattg     6480

acaggattat tggaaatttg ttataatgaa tgaaacattt tgtcatataa gattcatatt     6540

tacttcttat acatttgata aagtaaggca tggttgtggt taatctggtt tatttttgtt     6600

ccacaagtta aataaatcat aaaacttgat gtgttatctc ttatatctca ctcccactat     6660

taccccttta ttttcaaaca gggaaacagt cttcaagttc cacttggtaa aaaatgtgaa     6720

ccccttgtat atagagtttg gctcacagtg taaagggcct cagtgattca cattttccag     6780

attaggaatc tgatgctcaa agaagttaaa tggcatagtt ggggtgacac agctgtctag     6840

tgggaggcca gccttctata ttttagccag cgttctttcc tgcgggccag gtcatgagga     6900

gtatgcagac tctaagaggg agcaaaagta tctgaaggat ttaatatttt agcaaggaat     6960

agatatacaa tcatcccttg gtctccctgg gggattggtt tcaggacccc ttcttggaca     7020

ccaaatctat ggatatttaa gtcccttcta taaaatggta tagtatttgc atataaccta     7080

tccacatcct cctgtatact ttaaatcatt tctagattac ttgtaatacc taatacaatg     7140

taaatgctat gcaaatagtt gttattgttt aaggaataat gacaagaaaa aaaagtctgt     7200

acatgctcag taaagacaca accatccctt tttttcccca gtgtttttga tccatggttt     7260

gctgaatcca cagatgtgga gcccctggat acggaaggcc cgctgtactt tgaatgacaa     7320

ataacagatt taaaattttc aaggcatagt tttatacctg a                         7361


<210>  2
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M exon 1 target

<400>  2
tgacagcatt cgggccgaga tgtctcgctc cgtggcctta gctgtg                      46


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Target1

<400>  3
ggccgagatg tctcgctccg                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Target 2

<400>  4
cgcgagcaca gctaaggcca                                                   20


<210>  5
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Target1 forward primer

<400>  5
aaacggccga gatgtctcgc tccggt                                            26


<210>  6
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Target1reverse primer

<400>  6
taaaaccgga gcgagacatc tcggcc                                            26


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Target2 forward primer

<400>  7
cacccgcgag cacagctaag gcca                                              24


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Target2 reverse primer

<400>  8
aaactggcct tagctgtgct cgcg                                              24


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M EX1 WT forward primer

<400>  9
tctcgaatga aaaatgcagg tccg                                              24


<210>  10
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M EX1 WT reverse primer

<400>  10
tgacgcttat cgacgcccta aactt                                             25


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M EGFP HDR forward primer

<400>  11
ccacaacgtc tatatcatgg ccgac                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M EGFP HDR reverse primer

<400>  12
gtttgctctg gagaatctca cgcag                                             25


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M mCherry HDR forward primer

<400>  13
tctagagcct gcagtctcga caagc                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M mCherry HDR reverse primer

<400>  14
gtttgctctg gagaatctca cgcag                                             25


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe EGFP forward primer

<400>  15
cacctacggc aagctgaccc tgaagttcat                                        30


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe EGFP reverse primer

<400>  16
atgtgatcgc gcttctcgtt ggggtctttg                                        30


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target1 forward primer

<400>  17
ccccaaccag attgccccat                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target1 reverse primer

<400>  18
tccctgcagc ggatcctcaa                                                   20


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target2 forward primer

<400>  19
tccagctgca aaagggagaa gaga                                              24


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target2 reverse primer

<400>  20
agggaagaag ccaaagcgaa                                                   20


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target3 forward primer

<400>  21
tgcctgaggt ccaaggaaga gct                                               23


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target3 reverse primer

<400>  22
tgagcccaaa tccagccaca                                                   20


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target5 forward primer

<400>  23
agctgtatga cagcccctct gtgc                                              24


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target5 reverse primer

<400>  24
tagactcacg aggccggcga                                                   20


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target8 forward primer

<400>  25
cggtgactgt ggctgagact gagac                                             25


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target8 reverse primer

<400>  26
cgccgctacc ccgaagaaaa                                                   20


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target16 forward primer

<400>  27
aggaactggg gcttgaatgg gg                                                22


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Off-target16 reverse primer

<400>  28
ggctgttgcc cagtcctgga aa                                                22


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oct4 forward primer

<400>  29
gagcaaaacc cggaggagt                                                    19


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oct4 reverse primer

<400>  30
ttctctttcg ggcctgcac                                                    19


<210>  31
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sox2 forward primer

<400>  31
gggaaatggg aggggtgcaa aa                                                22


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sox2 reverse primer

<400>  32
ttgcgtgagt gtggatggga tt                                                22


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NANOG forward primer

<400>  33
gcttgccttg ctttgaagca                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NANOG reverse primer

<400>  34
ttcttgaccg ggaccttgtc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-actin forward primer

<400>  35
tggcacccag cacaatgaag                                                   20


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-actin reverse primer

<400>  36
gatggagggg ccggactc                                                     18


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pax6 forward primer

<400>  37
caataatgtt gacggtgact atc                                               23


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pax6 reverse primer

<400>  38
agaaggaagc gacactctg                                                    19


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-alpha forward primer

<400>  39
gtcattgctg aaaccgagaa tg                                                22


<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-alpha reverse primer

<400>  40
gcaaagtact ggatgacacg ct                                                22


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AFP forward primer

<400>  41
cccgaacttt ccaagccata                                                   20


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AFP reverse primer

<400>  42
tacatgggcc acatccagg                                                    19


<210>  43
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LPL forward primer

<400>  43
tcaactggat ggaggag                                                      17


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LPL reverse primer

<400>  44
ggggcttctg catactcaaa                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPAR-gamma forward primer

<400>  45
ctcctattga cccagaaagc                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPAR-gamma reverse primer

<400>  46
gtagagctga gtcttctcag                                                   20


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALP forward primer

<400>  47
tggagcttca gaagctcaac acca                                              24


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALP reverse primer

<400>  48
atctcgttgt ctgagtacca gtcc                                              24


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OCN forward primer

<400>  49
ggcagcgagg tagtgaagag                                                   20


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OCN reverse primer

<400>  50
cagcagagcg acaccctaga c                                                 21


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL2a forward primer

<400>  51
atgattcgcc tcggggctcc                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL2a reverse primer

<400>  52
cattactggg aactgggcgc                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACAN forward primer

<400>  53
cactgttacc gccacttccc                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACAN reverse primer

<400>  54
accagcggaa gtccccttcg                                                   20


<210>  55
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH forward primer

<400>  55
ccccttcatt gacctcaact aca                                               23


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH reverse primer

<400>  56
ttgctgatga tcttgaggct gt                                                22


<210>  57
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutation in exon 1 of allele 1

<400>  57
ccgagatgtc tcgctccgtg gttagctgtg ctcgcgctac tctct                       45


<210>  58
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutaion in exon 1 of allele 2

<400>  58
ccgagatgtc tcgctccgtg gcccttagct gtgctcgcgc tactctct                    48


<210>  59
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2nd mutaion in exon 1 of allele 2

<400>  59
ccgagatgtc tcgctccgtg ccttagctgt gctcgcgcta ctctct                      46


