                        SEQUENCE LISTING

<110>	Universidad Nacional del Litoral
        Consejo Nacional de Investigaciones Cientficas y Tcnicas (CONICET)
        Universidad Nacional de General San Martn

<120>	Modified human erythropoietin

<130>	-

<160>	26

<170>	Patent In version 3.5

<210>	1
<211>	579
<212>	DNA
<213>	DNA MUTEIN 15_17

<400>	1
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agaaacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579



<210>	2
<211>	193
<212>	PRT
<213>	AA - MUTEIN 15_17

<400>	2
Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Asn Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  3
<211>  579
<212>  DNA
<213>  DNA MUTEIN 45_47

<400>  3
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaacgtga ccttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  4
<211>  193
<212>  PRT
<213>  AA - MUTEIN 45_47

<400>  4

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Asn Val Thr Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  5
<211>  579
<212>  DNA
<213>  DNA MUTEIN 49

<400>  5
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttcaccgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  6
<211>  193
<212>  PRT
<213>  AA - MUTEIN 49

<400>  6

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Thr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  7
<211>  579
<212>  DNA
<213>  DNA - MUTEIN 62_64

<400>  7
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtgaacgtg acgcagggac tggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  8
<211>  193
<212>  PRT
<213>  AA - MUTEIN 62_64

<400>  8

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Asn Val Thr Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  9
<211>  579
<212>  DNA
<213>  DNA - MUTEIN  65_67

<400>  9
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggaacggaa cggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  10
<211>  193
<212>  PRT
<213>  AA - MUTEIN 65_67

<400>  10

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Asn Gly Thr Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  11
<211>  579
<212>  DNA
<213>  DNA - MUTEIN 72_74

<400>  11
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcaacgct      300

acgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  12
<211>  193
<212>  PRT
<213>  AA - MUTEIN 72_74

<400>  12

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Asn Ala Thr Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  13
<211>  579
<212>  DNA
<213>  DNA - MUTEIN 76_78

<400>  13
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcgaggct      300

gtgctgaacg gaacggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  14
<211>  193
<212>  PRT
<213>  AA- MUTEIN 76_78

<400>  14

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Asn Gly Thr Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  15
<211>  579
<212>  DNA
<213>  DNA - MUTEIN 98_100

<400>  15
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca agaatgtgac cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  16
<211>  193
<212>  PRT
<213>  AA- MUTEIN 98_100

<400>  16

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Asn Val Thr Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  17
<211>  579
<212>  DNA
<213>  DNA - MUTEIN 104

<400>  17
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga aacctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  18
<211>  193
<212>  PRT
<213>  AA - MUTEIN 104

<400>  18

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Asn Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  19
<211>  579
<212>  DNA
<213>  DNA - MUTEIN 106_108

<400>  19
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgaaca ccacgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  20
<211>  193
<212>  PRT
<213>  AA - MUTEIN 106_108

<400>  20

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Asn Thr Thr Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  21
<211>  579
<212>  DNA
<213>  DNA - MUTEIN 149

<400>  21
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcacgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  22
<211>  193
<212>  PRT
<213>  AA - MUTEIN 149

<400>  22

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Thr 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  23
<211>  579
<212>  DNA
<213>  DNA - MUTEIN 151_153

<400>  23
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gaacaagacg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  24
<211>  193
<212>  PRT
<213>  AA - MUTEIN 151_153

<400>  24

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Asn Lys Thr Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  25
<211>  579
<212>  DNA
<213>  DNA - hEPO

<400>  25
atgggcgtgc acgaatgtcc tgcttggctg tggctgctgc tgtccctgct gtctctgcct       60

ctgggactgc ctgtgctggg cgctcctcct agactgatct gcgactcccg ggtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca ccggctgcgc cgagcactgc      180

tccctgaacg agaatatcac cgtgcccgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtg tggcagggac tggctctgct gagcgaggct      300

gtgctgagag gacaggccct gctcgtgaac tcctcccagc cttgggaacc cctgcagctg      360

cacgtggaca aggctgtgtc cggcctgaga tccctgacca ccctgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgac gccgcctctg ctgctcctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtactcca acttcctgcg gggcaagctg      540

aagctgtaca ccggcgaggc ttgccggacc ggcgacaga                             579


<210>  26
<211>  193
<212>  PRT
<213>  AA - hEPO

<400>  26

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
