                         SEQUENCE LISTING

<110>  The Chancellor, Masters and Scholars of the University of 
       Cambridge; University of Westminster; Universitat Regensburg
 
<120>  Vaccines

<130>  P/79615.WO01

<140>  GB 1815957.4
<141>  2018-09-28

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  1578
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ebola Sudan (T2-4)

<400>  1
atgggaggac tgtctctgct gcaactgccc cgggacaagt tccggaagtc cagcttcttc       60

gtgtgggtca tcatcctgtt ccagaaagcc ttcagcatgc ccctgggcgt cgtgaccaat      120

agcacactgg aagtgaccga gatcgaccag ctcgtgtgca aggatcacct ggccagcacc      180

gatcagctga agtctgtggg actgaatctg gaaggcagcg gcgtgtccac agatatccct      240

agcgccacca agagatgggg ctttagaagc ggagtgcctc ctaaggtggt gtcttatgaa      300

gccggcgagt gggccgagaa ctgctacaac ctggaaatca agaagcccga cggcagcgag      360

tgtctgcctc ctccacctga tggcgtcaga ggcttcccta gatgcagata cgtgcacaag      420

gcccaaggca caggaccctg tcctggcgat tacgcctttc acaaggacgg cgcctttttc      480

ctgtacgatc ggctggcctc caccgtgatc tacagaggcg ttaactttgc cgagggcgtg      540

atcgccttcc tgatcctggc caagcctaaa gagacattcc tgcaaagccc tccaatccgc      600

gaggccgtga actacacaga gaacaccagc agctactacg ccaccagcta cctggaatac      660

gagatcgaga atttcggcgc ccagcacagc accacactgt tcaagatcga caacaacacc      720

ttcgtgcggc tggacagacc ccacacacct cagtttctgt tccagctgaa cgacaccatc      780

catctgcatc agcagctgag caacaccacc ggcagactga tttggaccct ggacgccaac      840

atcaacgccg acattggaga gtgggccttt tgggagaaca agaagaacct gagcgaacag      900

ctgagaggcg aggaactgag ctttgaggcc ctgtctctga ccaccgccgt gaaaacagtg      960

ctgcctcaag agtccaccag caacggcctg atcacaagca cagtgacagg catcctgggc     1020

agcctgggcc tgagaaaaag gtccagacgg caagtgaata ccaaggccac cggcaagtgc     1080

aaccccaacc tgcactattg gacagcccaa gagcagcaca atgccgccgg aatcgcctgg     1140

attccttatt ttggacctgg cgccgagggc atctataccg agggactgat gcacaaccag     1200

aacgccctcg tgtgtggact gagacagctg gccaatgaga caacacaggc cctccagctg     1260

tttctgagag ccaccaccga gctgagaacc tacaccatcc tgaaccggaa ggccatcgac     1320

tttctgctga gaagatgggg cggcacctgt agaatcctgg gacctgattg ctgcatcgag     1380

ccccacgact ggaccaagaa catcaccgac aagatcaacc agatcatcca cgacttcatc     1440

gacaaccctc tgcctaacca ggacaacgac gacaattggt ggacaggctg gcggcagtgg     1500

attcctgccg gaattggcat caccggcatc atcattgcca ttatcgccct gctgtgtgtg     1560

tgcaagctgc tgtgttga                                                   1578


<210>  2
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ebola Sudan (T2-4)

<400>  2

Met Gly Gly Leu Ser Leu Leu Gln Leu Pro Arg Asp Lys Phe Arg Lys 
1               5                   10                  15      


Ser Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe Ser 
            20                  25                  30          


Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Glu Val Thr Glu Ile 
        35                  40                  45              


Asp Gln Leu Val Cys Lys Asp His Leu Ala Ser Thr Asp Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Ser Gly Val Ser Thr Asp Ile Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Ala Gln Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Asp Tyr Ala Phe His Lys Asp Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Val Asn Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ala Lys Pro Lys Glu Thr 
            180                 185                 190         


Phe Leu Gln Ser Pro Pro Ile Arg Glu Ala Val Asn Tyr Thr Glu Asn 
        195                 200                 205             


Thr Ser Ser Tyr Tyr Ala Thr Ser Tyr Leu Glu Tyr Glu Ile Glu Asn 
    210                 215                 220                 


Phe Gly Ala Gln His Ser Thr Thr Leu Phe Lys Ile Asp Asn Asn Thr 
225                 230                 235                 240 


Phe Val Arg Leu Asp Arg Pro His Thr Pro Gln Phe Leu Phe Gln Leu 
                245                 250                 255     


Asn Asp Thr Ile His Leu His Gln Gln Leu Ser Asn Thr Thr Gly Arg 
            260                 265                 270         


Leu Ile Trp Thr Leu Asp Ala Asn Ile Asn Ala Asp Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Leu Ser Glu Gln Leu Arg Gly Glu 
    290                 295                 300                 


Glu Leu Ser Phe Glu Ala Leu Ser Leu Thr Thr Ala Val Lys Thr Val 
305                 310                 315                 320 


Leu Pro Gln Glu Ser Thr Ser Asn Gly Leu Ile Thr Ser Thr Val Thr 
                325                 330                 335     


Gly Ile Leu Gly Ser Leu Gly Leu Arg Lys Arg Ser Arg Arg Gln Val 
            340                 345                 350         


Asn Thr Lys Ala Thr Gly Lys Cys Asn Pro Asn Leu His Tyr Trp Thr 
        355                 360                 365             


Ala Gln Glu Gln His Asn Ala Ala Gly Ile Ala Trp Ile Pro Tyr Phe 
    370                 375                 380                 


Gly Pro Gly Ala Glu Gly Ile Tyr Thr Glu Gly Leu Met His Asn Gln 
385                 390                 395                 400 


Asn Ala Leu Val Cys Gly Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln 
                405                 410                 415     


Ala Leu Gln Leu Phe Leu Arg Ala Thr Thr Glu Leu Arg Thr Tyr Thr 
            420                 425                 430         


Ile Leu Asn Arg Lys Ala Ile Asp Phe Leu Leu Arg Arg Trp Gly Gly 
        435                 440                 445             


Thr Cys Arg Ile Leu Gly Pro Asp Cys Cys Ile Glu Pro His Asp Trp 
    450                 455                 460                 


Thr Lys Asn Ile Thr Asp Lys Ile Asn Gln Ile Ile His Asp Phe Ile 
465                 470                 475                 480 


Asp Asn Pro Leu Pro Asn Gln Asp Asn Asp Asp Asn Trp Trp Thr Gly 
                485                 490                 495     


Trp Arg Gln Trp Ile Pro Ala Gly Ile Gly Ile Thr Gly Ile Ile Ile 
            500                 505                 510         


Ala Ile Ile Ala Leu Leu Cys Val Cys Lys Leu Leu Cys 
        515                 520                 525 


<210>  3
<211>  1581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ebola Sudan (T2-6)

<400>  3
atgggcggag gatctagact gctgcaactg cccagagagc ggttcagaaa gaccagcttc       60

ttcgtgtggg tcatcatcct gttccagaaa gccttcagca tgcccctggg cgtcgtgacc      120

aatagcaccc tgaaagtgac cgagatcgac cagctcgtgt gcagagataa gctgagcagc      180

accagccagc tgaagtccgt gggactgaat ctggaaggca atggcgtggc cacagatgtg      240

cctagcgcca ccaaaagatg gggctttaga agcggcgtgc cacctaaggt ggtgtcttat      300

gaagccggcg agtgggccga gaactgctac aacctggaaa tcaagaagcc cgacggcagc      360

gagtgtctgc ctcctccacc tgatggcgtc agaggcttcc ctagatgcag atacgtgcac      420

aaggtgcaag gcacaggccc ctgtcctggc gatttcgcct ttcacaagga cggcgccttt      480

ttcctgtacg atcggctggc ctccaccgtg atctacagag gcacaacatt tgccgaaggc      540

gtggtggcct tcctgatcct gcctaagcct aagaaggact tctttcagag ccctcctatc      600

cgcgagcctg tgaacacaac agaggacccc agcagctact acaccaccag cacactgagc      660

tacgagatcg ataacttcgg cgccaacaag accaagacac tgttcaaggt ggacaaccac      720

acctacgtgc agctggacag accccacaca cctcagtttc tggtgcagct gaacgagaca      780

atccacacca acaacagact gagcaacacc accggcaggc tgatctggac cctggatcct      840

aagatcgaca ccgacatcgg agagtgggcc ttttgggaga acaagaagaa cttcagcaag      900

cagctgagag gcgaggaact gagctttaag gccctgagca ccaagacagg cgccaacgct      960

gtggataccg atgagtctag caagcccggc ctgatcacca acacagttag aggcgttgcc     1020

gacctgctga gcccttggag aagaaagcgg agacaagtga accccaatac caccaacaag     1080

tgcaacccta acctgcacta ctggacagcc caggatgaag gcgctgctgt tggactggcc     1140

tggattcctt attttggacc tgccgccgag ggcatctaca cagagggaat catgcacaac     1200

cagaatggcc tgatctgcgg cctgagacag ctggccaatg agacaacaca ggccctccag     1260

ctgtttctga gagccaccac cgagctgaga acctacagca tcctgaaccg gaaggccatc     1320

gactttctgc tgcaaagatg gggaggcacc tgtagaatcc tgggacctga ttgctgcatc     1380

gagccccacg actggaccaa gaacatcacc gacaagatca accagatcat ccacgacttc     1440

atcgacaacc ctctgcctga ccaggacgac gacgataatt ggtggacagg atggcggcag     1500

tggattcctg ccggaatcgg aatcacaggc gtgatcattg ccattatcgc cctgctgtgc     1560

atctgcaagt ttctgtgctg a                                               1581


<210>  4
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ebola Sudan (T2-6)

<400>  4

Met Gly Gly Gly Ser Arg Leu Leu Gln Leu Pro Arg Glu Arg Phe Arg 
1               5                   10                  15      


Lys Thr Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe 
            20                  25                  30          


Ser Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Lys Val Thr Glu 
        35                  40                  45              


Ile Asp Gln Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu 
    50                  55                  60                  


Lys Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val 
65                  70                  75                  80  


Pro Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys 
                85                  90                  95      


Val Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu 
            100                 105                 110         


Glu Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp 
        115                 120                 125             


Gly Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Gln Gly 
    130                 135                 140                 


Thr Gly Pro Cys Pro Gly Asp Phe Ala Phe His Lys Asp Gly Ala Phe 
145                 150                 155                 160 


Phe Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr 
                165                 170                 175     


Phe Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Lys Pro Lys Lys 
            180                 185                 190         


Asp Phe Phe Gln Ser Pro Pro Ile Arg Glu Pro Val Asn Thr Thr Glu 
        195                 200                 205             


Asp Pro Ser Ser Tyr Tyr Thr Thr Ser Thr Leu Ser Tyr Glu Ile Asp 
    210                 215                 220                 


Asn Phe Gly Ala Asn Lys Thr Lys Thr Leu Phe Lys Val Asp Asn His 
225                 230                 235                 240 


Thr Tyr Val Gln Leu Asp Arg Pro His Thr Pro Gln Phe Leu Val Gln 
                245                 250                 255     


Leu Asn Glu Thr Ile His Thr Asn Asn Arg Leu Ser Asn Thr Thr Gly 
            260                 265                 270         


Arg Leu Ile Trp Thr Leu Asp Pro Lys Ile Asp Thr Asp Ile Gly Glu 
        275                 280                 285             


Trp Ala Phe Trp Glu Asn Lys Lys Asn Phe Ser Lys Gln Leu Arg Gly 
    290                 295                 300                 


Glu Glu Leu Ser Phe Lys Ala Leu Ser Thr Lys Thr Gly Ala Asn Ala 
305                 310                 315                 320 


Val Asp Thr Asp Glu Ser Ser Lys Pro Gly Leu Ile Thr Asn Thr Val 
                325                 330                 335     


Arg Gly Val Ala Asp Leu Leu Ser Pro Trp Arg Arg Lys Arg Arg Gln 
            340                 345                 350         


Val Asn Pro Asn Thr Thr Asn Lys Cys Asn Pro Asn Leu His Tyr Trp 
        355                 360                 365             


Thr Ala Gln Asp Glu Gly Ala Ala Val Gly Leu Ala Trp Ile Pro Tyr 
    370                 375                 380                 


Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr Glu Gly Ile Met His Asn 
385                 390                 395                 400 


Gln Asn Gly Leu Ile Cys Gly Leu Arg Gln Leu Ala Asn Glu Thr Thr 
                405                 410                 415     


Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr Thr Glu Leu Arg Thr Tyr 
            420                 425                 430         


Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe Leu Leu Gln Arg Trp Gly 
        435                 440                 445             


Gly Thr Cys Arg Ile Leu Gly Pro Asp Cys Cys Ile Glu Pro His Asp 
    450                 455                 460                 


Trp Thr Lys Asn Ile Thr Asp Lys Ile Asn Gln Ile Ile His Asp Phe 
465                 470                 475                 480 


Ile Asp Asn Pro Leu Pro Asp Gln Asp Asp Asp Asp Asn Trp Trp Thr 
                485                 490                 495     


Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile Gly Ile Thr Gly Val Ile 
            500                 505                 510         


Ile Ala Ile Ile Ala Leu Leu Cys Ile Cys Lys Phe Leu Cys 
        515                 520                 525     


<210>  5
<211>  2046
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Marburgvirus (T2-11)

<400>  5
atgaagacca tctactttct gatcagcctg atcctgatcc agagcatcaa gaccctgcct       60

gtgctggaaa tcgccagcaa cagtcagccc caggatgtgg atagcgtgtg tagcggcacc      120

ctccagaaaa ccgaggatgt gcacctgatg ggctttaccc tgagcggcca gaaagtggcc      180

gattctccac tggaagccag caagagatgg gcctttagaa ccggcgtgcc acctaagaac      240

gtcgagtaca cagagggcga agaggccaag acctgctaca acatcagcgt gaccgatcct      300

agcggcaaga gcctgctgct ggaccctcct agcaacatca gagactaccc caagtgcaag      360

accgtgcacc acatccaggg acagaatccc catgctcagg gaattgccct gcacctgtgg      420

ggcgcctttt tcctgtatga tcggatcgcc tccaccacca tgtacagagg caaagtgttc      480

accgagggca atatcgccgc catgatcgtg aacaagacag tgcacaagat gatcttcagc      540

cggcaaggcc agggctacag acacatgaat ctgaccagca ccaacaagta ctggaccagc      600

agcaacggca cccagaccaa tgatacaggc tgctttggcg ccctgcaaga gtacaacagc      660

accaagaatc agacatgcgc ccctagcaag atccctcctc cactgcctac tgccagacct      720

gagatcaagc ctaccagcac acctaccgac gccaccaagc tgaacaccac cgatccaaac      780

agcgacgacg aggatctgac aacaagcgga tctggctctg gcgagcaaga gccatacacc      840

acctctgatg ccgtgacaaa gcagggcctg agcagcacaa tgcctccaac accttctcca      900

cagcctagca cacctcagca aggcggcaac aacacaaatc actctcaggg cgccgtgacc      960

gagcctgaca agacaaatac cacagctcag cccagcatgc ctcctcacaa caccaccaca     1020

atctccacca acaacaccag caagcacaac ttcagcacac tgagcgcccc tctccagaat     1080

accaccaact acaataccca gagcaccgcc accgagaacg agcagacatc tgccccttct     1140

aagaccacac tgccacctac cggcaatcct accaccgcca agagcaccaa tagcacaaag     1200

ggccctacca ccaccgctcc taacaccaca aatggccact tcacaagccc aagtcctaca     1260

cctaacagca caacccagca cctggtgtac ttcagacgga agcggagcat cctttggcgc     1320

gagggcgata tgttcccttt cctggacggc ctgatcaaca ccgagatcga cttcgacccc     1380

attccaaaca ccgaaaccat cttcgacgag agccccagct tcaacacctc caccaatgag     1440

gaacagcaca cccctccaaa catctccctg accttcagct acttccccga caagaacggc     1500

gatacagcct acagcggcga gaatgagaat gactgcgacg ccgagctgcg gatttggagc     1560

gttcaagagg atgatctggc tgccggcctg agctggatcc ctttttttgg acctggcatc     1620

gagggcctgt acaccgccgg actgatcaag aaccagaaca acctcgtgtg cagactgcgg     1680

agactggcca atcagaccgc caagtctctg gaactgctgc tgcgcgtgac caccgaggaa     1740

agaaccttct ctctgatcaa ccggcacgcc atcgattttc tgctgaccag atggggcggc     1800

acctgtaaag ttctgggccc tgattgctgc atcggaatcg aggacctgag caagaacatc     1860

tccgagcaga tcgacaagat ccgcaaggac gagcagaaag aggaaacagg ctggggactc     1920

ggcggcaagt ggtggacatc tgattggggc gtgctgacca atctgggaat cctgctgctc     1980

ctgtctatcg ccgtgctgat cgccctgagc tgcatctgcc ggatcttcac caagtacatc     2040

ggctga                                                                2046


<210>  6
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Marburgvirus (T2-11)

<400>  6

Met Lys Thr Ile Tyr Phe Leu Ile Ser Leu Ile Leu Ile Gln Ser Ile 
1               5                   10                  15      


Lys Thr Leu Pro Val Leu Glu Ile Ala Ser Asn Ser Gln Pro Gln Asp 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Ser Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Val His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Ala Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Ile Pro Pro Pro Leu Pro Thr Ala Arg Pro 
225                 230                 235                 240 


Glu Ile Lys Pro Thr Ser Thr Pro Thr Asp Ala Thr Lys Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Val Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Gly Ala Val Thr 
305                 310                 315                 320 


Glu Pro Asp Lys Thr Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Phe Ser 
            340                 345                 350         


Thr Leu Ser Ala Pro Leu Gln Asn Thr Thr Asn Tyr Asn Thr Gln Ser 
        355                 360                 365             


Thr Ala Thr Glu Asn Glu Gln Thr Ser Ala Pro Ser Lys Thr Thr Leu 
    370                 375                 380                 


Pro Pro Thr Gly Asn Pro Thr Thr Ala Lys Ser Thr Asn Ser Thr Lys 
385                 390                 395                 400 


Gly Pro Thr Thr Thr Ala Pro Asn Thr Thr Asn Gly His Phe Thr Ser 
                405                 410                 415     


Pro Ser Pro Thr Pro Asn Ser Thr Thr Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Ser Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Thr Glu Ile Asp Phe Asp Pro Ile Pro Asn Thr 
    450                 455                 460                 


Glu Thr Ile Phe Asp Glu Ser Pro Ser Phe Asn Thr Ser Thr Asn Glu 
465                 470                 475                 480 


Glu Gln His Thr Pro Pro Asn Ile Ser Leu Thr Phe Ser Tyr Phe Pro 
                485                 490                 495     


Asp Lys Asn Gly Asp Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Lys Ile Arg Lys Asp Glu Gln Lys Glu Glu Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  7
<211>  1578
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tier 2-4

<400>  7
atgggaggac tgtctctgct gcaactgccc cgggacaagt tccggaagtc cagcttcttc       60

gtgtgggtca tcatcctgtt ccagaaagcc ttcagcatgc ccctgggcgt cgtgaccaat      120

agcacactgg aagtgaccga gatcgaccag ctcgtgtgca aggatcacct ggccagcacc      180

gatcagctga agtctgtggg actgaatctg gaaggcagcg gcgtgtccac agatatccct      240

agcgccacca agagatgggg ctttagaagc ggagtgcctc ctaaggtggt gtcttatgaa      300

gccggcgagt gggccgagaa ctgctacaac ctggaaatca agaagcccga cggcagcgag      360

tgtctgcctc ctccacctga tggcgtcaga ggcttcccta gatgcagata cgtgcacaag      420

gcccaaggca caggaccctg tcctggcgat tacgcctttc acaaggacgg cgcctttttc      480

ctgtacgatc ggctggcctc caccgtgatc tacagaggcg ttaactttgc cgagggcgtg      540

atcgccttcc tgatcctggc caagcctaaa gagacattcc tgcaaagccc tccaatccgc      600

gaggccgtga actacacaga gaacaccagc agctactacg ccaccagcta cctggaatac      660

gagatcgaga atttcggcgc ccagcacagc accacactgt tcaagatcga caacaacacc      720

ttcgtgcggc tggacagacc ccacacacct cagtttctgt tccagctgaa cgacaccatc      780

catctgcatc agcagctgag caacaccacc ggcagactga tttggaccct ggacgccaac      840

atcaacgccg acattggaga gtgggccttt tgggagaaca agaagaacct gagcgaacag      900

ctgagaggcg aggaactgag ctttgaggcc ctgtctctga ccaccgccgt gaaaacagtg      960

ctgcctcaag agtccaccag caacggcctg atcacaagca cagtgacagg catcctgggc     1020

agcctgggcc tgagaaaaag gtccagacgg caagtgaata ccaaggccac cggcaagtgc     1080

aaccccaacc tgcactattg gacagcccaa gagcagcaca atgccgccgg aatcgcctgg     1140

attccttatt ttggacctgg cgccgagggc atctataccg agggactgat gcacaaccag     1200

aacgccctcg tgtgtggact gagacagctg gccaatgaga caacacaggc cctccagctg     1260

tttctgagag ccaccaccga gctgagaacc tacaccatcc tgaaccggaa ggccatcgac     1320

tttctgctga gaagatgggg cggcacctgt agaatcctgg gacctgattg ctgcatcgag     1380

ccccacgact ggaccaagaa catcaccgac aagatcaacc agatcatcca cgacttcatc     1440

gacaaccctc tgcctaacca ggacaacgac gacaattggt ggacaggctg gcggcagtgg     1500

attcctgccg gaattggcat caccggcatc atcattgcca ttatcgccct gctgtgtgtg     1560

tgcaagctgc tgtgttga                                                   1578


<210>  8
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tier 2-4

<400>  8

Met Gly Gly Leu Ser Leu Leu Gln Leu Pro Arg Asp Lys Phe Arg Lys 
1               5                   10                  15      


Ser Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe Ser 
            20                  25                  30          


Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Glu Val Thr Glu Ile 
        35                  40                  45              


Asp Gln Leu Val Cys Lys Asp His Leu Ala Ser Thr Asp Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Ser Gly Val Ser Thr Asp Ile Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Ala Gln Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Asp Tyr Ala Phe His Lys Asp Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Val Asn Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ala Lys Pro Lys Glu Thr 
            180                 185                 190         


Phe Leu Gln Ser Pro Pro Ile Arg Glu Ala Val Asn Tyr Thr Glu Asn 
        195                 200                 205             


Thr Ser Ser Tyr Tyr Ala Thr Ser Tyr Leu Glu Tyr Glu Ile Glu Asn 
    210                 215                 220                 


Phe Gly Ala Gln His Ser Thr Thr Leu Phe Lys Ile Asp Asn Asn Thr 
225                 230                 235                 240 


Phe Val Arg Leu Asp Arg Pro His Thr Pro Gln Phe Leu Phe Gln Leu 
                245                 250                 255     


Asn Asp Thr Ile His Leu His Gln Gln Leu Ser Asn Thr Thr Gly Arg 
            260                 265                 270         


Leu Ile Trp Thr Leu Asp Ala Asn Ile Asn Ala Asp Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Leu Ser Glu Gln Leu Arg Gly Glu 
    290                 295                 300                 


Glu Leu Ser Phe Glu Ala Leu Ser Leu Thr Thr Ala Val Lys Thr Val 
305                 310                 315                 320 


Leu Pro Gln Glu Ser Thr Ser Asn Gly Leu Ile Thr Ser Thr Val Thr 
                325                 330                 335     


Gly Ile Leu Gly Ser Leu Gly Leu Arg Lys Arg Ser Arg Arg Gln Val 
            340                 345                 350         


Asn Thr Lys Ala Thr Gly Lys Cys Asn Pro Asn Leu His Tyr Trp Thr 
        355                 360                 365             


Ala Gln Glu Gln His Asn Ala Ala Gly Ile Ala Trp Ile Pro Tyr Phe 
    370                 375                 380                 


Gly Pro Gly Ala Glu Gly Ile Tyr Thr Glu Gly Leu Met His Asn Gln 
385                 390                 395                 400 


Asn Ala Leu Val Cys Gly Leu Arg Gln Leu Ala Asn Glu Thr Thr Gln 
                405                 410                 415     


Ala Leu Gln Leu Phe Leu Arg Ala Thr Thr Glu Leu Arg Thr Tyr Thr 
            420                 425                 430         


Ile Leu Asn Arg Lys Ala Ile Asp Phe Leu Leu Arg Arg Trp Gly Gly 
        435                 440                 445             


Thr Cys Arg Ile Leu Gly Pro Asp Cys Cys Ile Glu Pro His Asp Trp 
    450                 455                 460                 


Thr Lys Asn Ile Thr Asp Lys Ile Asn Gln Ile Ile His Asp Phe Ile 
465                 470                 475                 480 


Asp Asn Pro Leu Pro Asn Gln Asp Asn Asp Asp Asn Trp Trp Thr Gly 
                485                 490                 495     


Trp Arg Gln Trp Ile Pro Ala Gly Ile Gly Ile Thr Gly Ile Ile Ile 
            500                 505                 510         


Ala Ile Ile Ala Leu Leu Cys Val Cys Lys Leu Leu Cys 
        515                 520                 525 


<210>  9
<211>  1581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tier 2-6

<400>  9
atgggcggag gatctagact gctgcaactg cccagagagc ggttcagaaa gaccagcttc       60

ttcgtgtggg tcatcatcct gttccagaaa gccttcagca tgcccctggg cgtcgtgacc      120

aatagcaccc tgaaagtgac cgagatcgac cagctcgtgt gcagagataa gctgagcagc      180

accagccagc tgaagtccgt gggactgaat ctggaaggca atggcgtggc cacagatgtg      240

cctagcgcca ccaaaagatg gggctttaga agcggcgtgc cacctaaggt ggtgtcttat      300

gaagccggcg agtgggccga gaactgctac aacctggaaa tcaagaagcc cgacggcagc      360

gagtgtctgc ctcctccacc tgatggcgtc agaggcttcc ctagatgcag atacgtgcac      420

aaggtgcaag gcacaggccc ctgtcctggc gatttcgcct ttcacaagga cggcgccttt      480

ttcctgtacg atcggctggc ctccaccgtg atctacagag gcacaacatt tgccgaaggc      540

gtggtggcct tcctgatcct gcctaagcct aagaaggact tctttcagag ccctcctatc      600

cgcgagcctg tgaacacaac agaggacccc agcagctact acaccaccag cacactgagc      660

tacgagatcg ataacttcgg cgccaacaag accaagacac tgttcaaggt ggacaaccac      720

acctacgtgc agctggacag accccacaca cctcagtttc tggtgcagct gaacgagaca      780

atccacacca acaacagact gagcaacacc accggcaggc tgatctggac cctggatcct      840

aagatcgaca ccgacatcgg agagtgggcc ttttgggaga acaagaagaa cttcagcaag      900

cagctgagag gcgaggaact gagctttaag gccctgagca ccaagacagg cgccaacgct      960

gtggataccg atgagtctag caagcccggc ctgatcacca acacagttag aggcgttgcc     1020

gacctgctga gcccttggag aagaaagcgg agacaagtga accccaatac caccaacaag     1080

tgcaacccta acctgcacta ctggacagcc caggatgaag gcgctgctgt tggactggcc     1140

tggattcctt attttggacc tgccgccgag ggcatctaca cagagggaat catgcacaac     1200

cagaatggcc tgatctgcgg cctgagacag ctggccaatg agacaacaca ggccctccag     1260

ctgtttctga gagccaccac cgagctgaga acctacagca tcctgaaccg gaaggccatc     1320

gactttctgc tgcaaagatg gggaggcacc tgtagaatcc tgggacctga ttgctgcatc     1380

gagccccacg actggaccaa gaacatcacc gacaagatca accagatcat ccacgacttc     1440

atcgacaacc ctctgcctga ccaggacgac gacgataatt ggtggacagg atggcggcag     1500

tggattcctg ccggaatcgg aatcacaggc gtgatcattg ccattatcgc cctgctgtgc     1560

atctgcaagt ttctgtgctg a                                               1581


<210>  10
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tier 2-6

<400>  10

Met Gly Gly Gly Ser Arg Leu Leu Gln Leu Pro Arg Glu Arg Phe Arg 
1               5                   10                  15      


Lys Thr Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe 
            20                  25                  30          


Ser Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Lys Val Thr Glu 
        35                  40                  45              


Ile Asp Gln Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu 
    50                  55                  60                  


Lys Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val 
65                  70                  75                  80  


Pro Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys 
                85                  90                  95      


Val Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu 
            100                 105                 110         


Glu Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp 
        115                 120                 125             


Gly Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Gln Gly 
    130                 135                 140                 


Thr Gly Pro Cys Pro Gly Asp Phe Ala Phe His Lys Asp Gly Ala Phe 
145                 150                 155                 160 


Phe Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr 
                165                 170                 175     


Phe Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Lys Pro Lys Lys 
            180                 185                 190         


Asp Phe Phe Gln Ser Pro Pro Ile Arg Glu Pro Val Asn Thr Thr Glu 
        195                 200                 205             


Asp Pro Ser Ser Tyr Tyr Thr Thr Ser Thr Leu Ser Tyr Glu Ile Asp 
    210                 215                 220                 


Asn Phe Gly Ala Asn Lys Thr Lys Thr Leu Phe Lys Val Asp Asn His 
225                 230                 235                 240 


Thr Tyr Val Gln Leu Asp Arg Pro His Thr Pro Gln Phe Leu Val Gln 
                245                 250                 255     


Leu Asn Glu Thr Ile His Thr Asn Asn Arg Leu Ser Asn Thr Thr Gly 
            260                 265                 270         


Arg Leu Ile Trp Thr Leu Asp Pro Lys Ile Asp Thr Asp Ile Gly Glu 
        275                 280                 285             


Trp Ala Phe Trp Glu Asn Lys Lys Asn Phe Ser Lys Gln Leu Arg Gly 
    290                 295                 300                 


Glu Glu Leu Ser Phe Lys Ala Leu Ser Thr Lys Thr Gly Ala Asn Ala 
305                 310                 315                 320 


Val Asp Thr Asp Glu Ser Ser Lys Pro Gly Leu Ile Thr Asn Thr Val 
                325                 330                 335     


Arg Gly Val Ala Asp Leu Leu Ser Pro Trp Arg Arg Lys Arg Arg Gln 
            340                 345                 350         


Val Asn Pro Asn Thr Thr Asn Lys Cys Asn Pro Asn Leu His Tyr Trp 
        355                 360                 365             


Thr Ala Gln Asp Glu Gly Ala Ala Val Gly Leu Ala Trp Ile Pro Tyr 
    370                 375                 380                 


Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr Glu Gly Ile Met His Asn 
385                 390                 395                 400 


Gln Asn Gly Leu Ile Cys Gly Leu Arg Gln Leu Ala Asn Glu Thr Thr 
                405                 410                 415     


Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr Thr Glu Leu Arg Thr Tyr 
            420                 425                 430         


Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe Leu Leu Gln Arg Trp Gly 
        435                 440                 445             


Gly Thr Cys Arg Ile Leu Gly Pro Asp Cys Cys Ile Glu Pro His Asp 
    450                 455                 460                 


Trp Thr Lys Asn Ile Thr Asp Lys Ile Asn Gln Ile Ile His Asp Phe 
465                 470                 475                 480 


Ile Asp Asn Pro Leu Pro Asp Gln Asp Asp Asp Asp Asn Trp Trp Thr 
                485                 490                 495     


Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile Gly Ile Thr Gly Val Ile 
            500                 505                 510         


Ile Ala Ile Ile Ala Leu Leu Cys Ile Cys Lys Phe Leu Cys 
        515                 520                 525     


<210>  11
<211>  2046
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tier 2-11

<400>  11
atgaagacca tctactttct gatcagcctg atcctgatcc agagcatcaa gaccctgcct       60

gtgctggaaa tcgccagcaa cagtcagccc caggatgtgg atagcgtgtg tagcggcacc      120

ctccagaaaa ccgaggatgt gcacctgatg ggctttaccc tgagcggcca gaaagtggcc      180

gattctccac tggaagccag caagagatgg gcctttagaa ccggcgtgcc acctaagaac      240

gtcgagtaca cagagggcga agaggccaag acctgctaca acatcagcgt gaccgatcct      300

agcggcaaga gcctgctgct ggaccctcct agcaacatca gagactaccc caagtgcaag      360

accgtgcacc acatccaggg acagaatccc catgctcagg gaattgccct gcacctgtgg      420

ggcgcctttt tcctgtatga tcggatcgcc tccaccacca tgtacagagg caaagtgttc      480

accgagggca atatcgccgc catgatcgtg aacaagacag tgcacaagat gatcttcagc      540

cggcaaggcc agggctacag acacatgaat ctgaccagca ccaacaagta ctggaccagc      600

agcaacggca cccagaccaa tgatacaggc tgctttggcg ccctgcaaga gtacaacagc      660

accaagaatc agacatgcgc ccctagcaag atccctcctc cactgcctac tgccagacct      720

gagatcaagc ctaccagcac acctaccgac gccaccaagc tgaacaccac cgatccaaac      780

agcgacgacg aggatctgac aacaagcgga tctggctctg gcgagcaaga gccatacacc      840

acctctgatg ccgtgacaaa gcagggcctg agcagcacaa tgcctccaac accttctcca      900

cagcctagca cacctcagca aggcggcaac aacacaaatc actctcaggg cgccgtgacc      960

gagcctgaca agacaaatac cacagctcag cccagcatgc ctcctcacaa caccaccaca     1020

atctccacca acaacaccag caagcacaac ttcagcacac tgagcgcccc tctccagaat     1080

accaccaact acaataccca gagcaccgcc accgagaacg agcagacatc tgccccttct     1140

aagaccacac tgccacctac cggcaatcct accaccgcca agagcaccaa tagcacaaag     1200

ggccctacca ccaccgctcc taacaccaca aatggccact tcacaagccc aagtcctaca     1260

cctaacagca caacccagca cctggtgtac ttcagacgga agcggagcat cctttggcgc     1320

gagggcgata tgttcccttt cctggacggc ctgatcaaca ccgagatcga cttcgacccc     1380

attccaaaca ccgaaaccat cttcgacgag agccccagct tcaacacctc caccaatgag     1440

gaacagcaca cccctccaaa catctccctg accttcagct acttccccga caagaacggc     1500

gatacagcct acagcggcga gaatgagaat gactgcgacg ccgagctgcg gatttggagc     1560

gttcaagagg atgatctggc tgccggcctg agctggatcc ctttttttgg acctggcatc     1620

gagggcctgt acaccgccgg actgatcaag aaccagaaca acctcgtgtg cagactgcgg     1680

agactggcca atcagaccgc caagtctctg gaactgctgc tgcgcgtgac caccgaggaa     1740

agaaccttct ctctgatcaa ccggcacgcc atcgattttc tgctgaccag atggggcggc     1800

acctgtaaag ttctgggccc tgattgctgc atcggaatcg aggacctgag caagaacatc     1860

tccgagcaga tcgacaagat ccgcaaggac gagcagaaag aggaaacagg ctggggactc     1920

ggcggcaagt ggtggacatc tgattggggc gtgctgacca atctgggaat cctgctgctc     1980

ctgtctatcg ccgtgctgat cgccctgagc tgcatctgcc ggatcttcac caagtacatc     2040

ggctga                                                                2046


<210>  12
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tier 2-11

<400>  12

Met Lys Thr Ile Tyr Phe Leu Ile Ser Leu Ile Leu Ile Gln Ser Ile 
1               5                   10                  15      


Lys Thr Leu Pro Val Leu Glu Ile Ala Ser Asn Ser Gln Pro Gln Asp 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Ser Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Val His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Ala Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Ile Pro Pro Pro Leu Pro Thr Ala Arg Pro 
225                 230                 235                 240 


Glu Ile Lys Pro Thr Ser Thr Pro Thr Asp Ala Thr Lys Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Val Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Gly Ala Val Thr 
305                 310                 315                 320 


Glu Pro Asp Lys Thr Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Phe Ser 
            340                 345                 350         


Thr Leu Ser Ala Pro Leu Gln Asn Thr Thr Asn Tyr Asn Thr Gln Ser 
        355                 360                 365             


Thr Ala Thr Glu Asn Glu Gln Thr Ser Ala Pro Ser Lys Thr Thr Leu 
    370                 375                 380                 


Pro Pro Thr Gly Asn Pro Thr Thr Ala Lys Ser Thr Asn Ser Thr Lys 
385                 390                 395                 400 


Gly Pro Thr Thr Thr Ala Pro Asn Thr Thr Asn Gly His Phe Thr Ser 
                405                 410                 415     


Pro Ser Pro Thr Pro Asn Ser Thr Thr Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Ser Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Thr Glu Ile Asp Phe Asp Pro Ile Pro Asn Thr 
    450                 455                 460                 


Glu Thr Ile Phe Asp Glu Ser Pro Ser Phe Asn Thr Ser Thr Asn Glu 
465                 470                 475                 480 


Glu Gln His Thr Pro Pro Asn Ile Ser Leu Thr Phe Ser Tyr Phe Pro 
                485                 490                 495     


Asp Lys Asn Gly Asp Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Lys Ile Arg Lys Asp Glu Gln Lys Glu Glu Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  13
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-10 = LASV_III_IV_anc

<400>  13

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Leu Leu Ala Ile Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Val Ala Thr Cys Gly Leu Ile Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Ser Thr Thr Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Arg 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Val Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Leu Leu Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Asn 
            260                 265                 270         


Glu Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Arg Arg Leu Lys Ala Glu Ala Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Ile Thr Gly Lys Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Asp Arg Gln Gly Lys Thr Pro Leu Gly Leu Val Asp 
            420                 425                 430         


Leu Phe Val Phe Ser Thr Ser Phe Tyr Leu Ile Ser Ile Phe Leu His 
        435                 440                 445             


Leu Val Lys Ile Pro Thr His Arg His Ile Val Gly Lys Pro Cys Pro 
    450                 455                 460                 


Lys Pro His Arg Leu Asn His Met Gly Ile Cys Ser Cys Gly Leu Tyr 
465                 470                 475                 480 


Lys Gln Pro Gly Val Pro Val Arg Trp Lys Arg 
                485                 490     


<210>  14
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-10 = LASV_III_IV_anc

<400>  14
atgggccaga tcgtgacatt cttccaagag gtgccccacg tgatcgaaga agtgatgaac       60

atcgtcctga tcgccctgag cctgctggcc atcctgaagg gcctgtataa tgtggccacc      120

tgtggcctga tcggcctggt cacatttctg ctgctgtgcg gcagaagctg ctccaccaca      180

ctgtataagg gcgtgtacga gctgcaaacc ctggaactga acatggaaac cctgaacatg      240

accatgcctc tgagctgcac caagaacaac agccaccact acatcagagt gggcaacgag      300

acaggcctcg agctgaccct gaccaacacc agcatcatca accacaagtt ctgcaacctg      360

agcgacgccc acaagaagaa cctgtacgat cacgccctga tgagcatcat ctccaccttc      420

cacctgagca tccccaactt caaccagtac gaggccatga gctgcgactt caacggcgga      480

aagatcagcg tgcagtacaa tctgagccac agctatgccg tggacgccgc caatcattgt      540

ggaacagtgg ccaatggcgt gctccagacc ttcatgagaa tggcctgggg cggcagctat      600

atcgccctgg attctggcag aggcaactgg gactgcatca tgaccagcta ccagtacctg      660

atcatccaga acaccacctg ggaagatcac tgccagttca gcagaccctc tcctatcgga      720

tacctgggcc tgctgtccca gagaacccgg gacatctaca tctctagacg gctgctgggc      780

accttcacct ggacactgtc tgatagcgag ggcaatgaga cacctggcgg ctactgtctg      840

acccggtgga tgctgattga ggccgagctg aagtgcttcg gaaataccgc cgtggccaag      900

tgcaacgaga agcacgacga ggaattctgc gacatgctgc ggctgttcga tttcaacaag      960

caggccatca gacggctgaa ggccgaggct cagatgtcca tccagctgat caacaaggcc     1020

gtgaatgccc tgattaacga ccagctcatc atgaagaacc acctcaggga catcatgggc     1080

atcccttact gcaactacag caagtactgg tatctgaacc acaccatcac cggcaagacc     1140

agcctgccta agtgctggct ggtgtccaac ggcagctacc tgaacgagac acacttcagc     1200

gacgacatcg agcagcaggc cgacaacatg atcaccgaga tgctccagaa agagtacatg     1260

gaccggcagg gcaagacacc tctgggcctt gtggatctgt tcgtgttcag caccagcttc     1320

tacctgatct ctatcttcct gcacctggtc aagatcccca cacacagaca catcgtgggc     1380

aagccctgtc ctaagcctca cagactgaac catatgggca tctgtagctg cggcctgtac     1440

aaacagcctg gcgtgccagt gcggtggaag agataa                               1476


<210>  15
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-10-SOSEP

<400>  15

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Leu Leu Ala Ile Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Val Ala Thr Cys Gly Leu Ile Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Ser Thr Thr Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Arg 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Val Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Cys Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Arg Arg Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Asn 
            260                 265                 270         


Glu Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Arg Arg Leu Lys Ala Pro Ala Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Cys Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Ile Thr Gly Lys Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Asp Arg Gln Gly Lys Thr Pro Leu Gly Leu Val Asp 
            420                 425                 430         


Leu Phe Val Phe Ser Thr Ser Phe Tyr Leu Ile Ser Ile Phe Leu His 
        435                 440                 445             


Leu Val Lys Ile Pro Thr His Arg His Ile Val Gly Lys Pro Cys Pro 
    450                 455                 460                 


Lys Pro His Arg Leu Asn His Met Gly Ile Cys Ser Cys Gly Leu Tyr 
465                 470                 475                 480 


Lys Gln Pro Gly Val Pro Val Arg Trp Lys Arg 
                485                 490     


<210>  16
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-10-SOSEP

<400>  16
atgggccaga tcgtgacatt cttccaagag gtgccccacg tgatcgaaga agtgatgaac       60

atcgtcctga tcgccctgag cctgctggcc atcctgaagg gcctgtataa tgtggccacc      120

tgtggcctga tcggcctggt cacatttctg ctgctgtgcg gcagaagctg ctccaccaca      180

ctgtataagg gcgtgtacga gctgcaaacc ctggaactga acatggaaac cctgaacatg      240

accatgcctc tgagctgcac caagaacaac agccaccact acatcagagt gggcaacgag      300

acaggcctcg agctgaccct gaccaacacc agcatcatca accacaagtt ctgcaacctg      360

agcgacgccc acaagaagaa cctgtacgat cacgccctga tgagcatcat ctccaccttc      420

cacctgagca tccccaactt caaccagtac gaggccatga gctgcgactt caacggcgga      480

aagatcagcg tgcagtacaa tctgagccac agctatgccg tggacgccgc caatcattgt      540

ggaacagtgg ccaatggcgt gctccagacc ttcatgagaa tggcctgggg cggcagctat      600

atcgccctgg attctggctg tggcaactgg gactgcatca tgaccagcta ccagtacctg      660

atcatccaga acaccacctg ggaagatcac tgccagttca gcagaccctc tcctatcgga      720

tacctgggcc tgctgtccca gagaacccgg gacatctaca tctctcggcg gagaagaggc      780

accttcacct ggacactgtc tgatagcgag ggcaatgaga cacctggcgg ctactgtctg      840

acccggtgga tgctgattga ggccgagctg aagtgcttcg gaaataccgc cgtggccaag      900

tgcaacgaga agcacgacga ggaattctgc gacatgctgc ggctgttcga tttcaacaag      960

caggccatca gacggctgaa ggcccctgct cagatgtcca tccagctgat caacaaggcc     1020

gtgaatgccc tgattaacga ccagctcatc atgaagaacc acctcaggga catcatgtgc     1080

atcccttact gcaactacag caagtactgg tatctgaacc acaccatcac cggcaagacc     1140

agcctgccta agtgctggct ggtgtccaac ggcagctacc tgaacgagac acacttcagc     1200

gacgacatcg agcagcaggc cgacaacatg atcaccgaga tgctccagaa agagtacatg     1260

gaccggcagg gcaagacacc tctgggcctt gtggatctgt tcgtgttcag caccagcttc     1320

tacctgatct ctatcttcct gcacctggtc aagatcccca cacacagaca catcgtgggc     1380

aagccctgtc ctaagcctca cagactgaac catatgggca tctgtagctg cggcctgtac     1440

aaacagcctg gcgtgccagt gcggtggaag agataa                               1476


<210>  17
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-10-SOSEP-NtoK

<400>  17

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Leu Leu Ala Ile Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Val Ala Thr Cys Gly Leu Ile Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Ser Thr Thr Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Arg 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Val Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Cys Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Arg Arg Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Lys 
            260                 265                 270         


Glu Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Arg Arg Leu Lys Ala Pro Ala Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Cys Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Ile Thr Gly Lys Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Asp Arg Gln Gly Lys Thr Pro Leu Gly Leu Val Asp 
            420                 425                 430         


Leu Phe Val Phe Ser Thr Ser Phe Tyr Leu Ile Ser Ile Phe Leu His 
        435                 440                 445             


Leu Val Lys Ile Pro Thr His Arg His Ile Val Gly Lys Pro Cys Pro 
    450                 455                 460                 


Lys Pro His Arg Leu Asn His Met Gly Ile Cys Ser Cys Gly Leu Tyr 
465                 470                 475                 480 


Lys Gln Pro Gly Val Pro Val Arg Trp Lys Arg 
                485                 490     


<210>  18
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-10-SOSEP-NtoK

<400>  18
atgggccaga tcgtgacatt cttccaagag gtgccccacg tgatcgaaga agtgatgaac       60

atcgtcctga tcgccctgag cctgctggcc atcctgaagg gcctgtataa tgtggccacc      120

tgtggcctga tcggcctggt cacatttctg ctgctgtgcg gcagaagctg ctccaccaca      180

ctgtataagg gcgtgtacga gctgcaaacc ctggaactga acatggaaac cctgaacatg      240

accatgcctc tgagctgcac caagaacaac agccaccact acatcagagt gggcaacgag      300

acaggcctcg agctgaccct gaccaacacc agcatcatca accacaagtt ctgcaacctg      360

agcgacgccc acaagaagaa cctgtacgat cacgccctga tgagcatcat ctccaccttc      420

cacctgagca tccccaactt caaccagtac gaggccatga gctgcgactt caacggcgga      480

aagatcagcg tgcagtacaa tctgagccac agctatgccg tggacgccgc caatcattgt      540

ggaacagtgg ccaatggcgt gctccagacc ttcatgagaa tggcctgggg cggcagctat      600

atcgccctgg attctggctg tggcaactgg gactgcatca tgaccagcta ccagtacctg      660

atcatccaga acaccacctg ggaagatcac tgccagttca gcagaccctc tcctatcgga      720

tacctgggcc tgctgtccca gagaacccgg gacatctaca tctctcggcg gagaagaggc      780

accttcacct ggacactgtc tgatagcgag ggcaaagaga cacctggcgg ctactgtctg      840

acccggtgga tgctgattga ggccgagctg aagtgcttcg gaaataccgc cgtggccaag      900

tgcaacgaga agcacgacga ggaattctgc gacatgctgc ggctgttcga tttcaacaag      960

caggccatca gacggctgaa ggcccctgct cagatgtcca tccagctgat caacaaggcc     1020

gtgaatgccc tgattaacga ccagctcatc atgaagaacc acctcaggga catcatgtgc     1080

atcccttact gcaactacag caagtactgg tatctgaacc acaccatcac cggcaagacc     1140

agcctgccta agtgctggct ggtgtccaac ggcagctacc tgaacgagac acacttcagc     1200

gacgacatcg agcagcaggc cgacaacatg atcaccgaga tgctccagaa agagtacatg     1260

gaccggcagg gcaagacacc tctgggcctt gtggatctgt tcgtgttcag caccagcttc     1320

tacctgatct ctatcttcct gcacctggtc aagatcccca cacacagaca catcgtgggc     1380

aagccctgtc ctaagcctca cagactgaac catatgggca tctgtagctg cggcctgtac     1440

aaacagcctg gcgtgccagt gcggtggaag agataa                               1476


<210>  19
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-10-FLEP

<400>  19

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Leu Leu Ala Ile Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Val Ala Thr Cys Gly Leu Ile Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Ser Thr Thr Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Arg 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Val Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Glu Gly Asn Glu Thr Pro Gly Gly Tyr Cys Leu Thr Arg 
        275                 280                 285             


Trp Met Leu Ile Glu Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Glu Lys His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Phe Asp Phe Asn Lys Gln Ala Ile Arg Arg Leu Lys Ala Pro Ala 
                325                 330                 335     


Gln Met Ser Ile Gln Leu Ile Asn Lys Ala Val Asn Ala Leu Ile Asn 
            340                 345                 350         


Asp Gln Leu Ile Met Lys Asn His Leu Arg Asp Ile Met Gly Ile Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Tyr Trp Tyr Leu Asn His Thr Ile Thr Gly 
    370                 375                 380                 


Lys Thr Ser Leu Pro Lys Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Asp Ile Glu Gln Gln Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Gln Lys Glu Tyr Met Asp Arg Gln Gly Lys Thr 
            420                 425                 430         


Pro Leu Gly Leu Val Asp Leu Phe Val Phe Ser Thr Ser Phe Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Val Gly Lys Pro Cys Pro Lys Pro His Arg Leu Asn His Met Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Leu Tyr Lys Gln Pro Gly Val Pro Val Arg Trp Lys 
                485                 490                 495     


Arg 
    


<210>  20
<211>  1494
<212>  DNA
<213>  Artificial Sequnece

<220>
<223>  L-10-FLEP

<400>  20
atgggccaga tcgtgacatt cttccaagag gtgccccacg tgatcgaaga agtgatgaac       60

atcgtcctga tcgccctgag cctgctggcc atcctgaagg gcctgtataa tgtggccacc      120

tgtggcctga tcggcctggt cacatttctg ctgctgtgcg gcagaagctg ctccaccaca      180

ctgtataagg gcgtgtacga gctgcaaacc ctggaactga acatggaaac cctgaacatg      240

accatgcctc tgagctgcac caagaacaac agccaccact acatcagagt gggcaacgag      300

acaggcctcg agctgaccct gaccaacacc agcatcatca accacaagtt ctgcaacctg      360

agcgacgccc acaagaagaa cctgtacgat cacgccctga tgagcatcat ctccaccttc      420

cacctgagca tccccaactt caaccagtac gaggccatga gctgcgactt caacggcgga      480

aagatcagcg tgcagtacaa tctgagccac agctatgccg tggacgccgc caatcattgt      540

ggaacagtgg ccaatggcgt gctccagacc ttcatgagaa tggcctgggg cggcagctat      600

atcgccctgg attctggcag aggcaactgg gactgcatca tgaccagcta ccagtacctg      660

atcatccaga acaccacctg ggaagatcac tgccagttca gcagaccctc tcctatcgga      720

tacctgggcc tgctgtccca gagaacccgg gacatctaca tctctggcgg cggaggatct      780

ggcggaggtg gaagtggcac cttcacctgg acactgtctg atagcgaggg caatgagaca      840

cctggcggct actgtctgac ccggtggatg ctgattgagg ccgagctgaa gtgcttcgga      900

aataccgccg tggccaagtg caacgagaag cacgacgagg aattctgcga catgctgcgg      960

ctgttcgatt tcaacaagca ggccatcaga cggctgaagg cccctgctca gatgtccatc     1020

cagctgatca acaaggccgt gaatgccctg attaacgacc agctcatcat gaagaaccac     1080

ctcagggaca tcatgggcat cccttactgc aactacagca agtactggta tctgaaccac     1140

accatcaccg gcaagaccag cctgcctaag tgctggctgg tgtccaacgg cagctacctg     1200

aacgagacac acttcagcga cgacatcgag cagcaggccg acaacatgat caccgagatg     1260

ctccagaaag agtacatgga ccggcagggc aagacacctc tgggccttgt ggatctgttc     1320

gtgttcagca ccagcttcta cctgatctct atcttcctgc acctggtcaa gatccccaca     1380

cacagacaca tcgtgggcaa gccctgtcct aagcctcaca gactgaacca tatgggcatc     1440

tgtagctgcg gcctgtacaa acagcctggc gtgccagtgc ggtggaagag ataa           1494


<210>  21
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-10-FLEP-NtoK

<400>  21

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Leu Leu Ala Ile Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Val Ala Thr Cys Gly Leu Ile Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Ser Thr Thr Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Arg 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Val Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Glu Gly Lys Glu Thr Pro Gly Gly Tyr Cys Leu Thr Arg 
        275                 280                 285             


Trp Met Leu Ile Glu Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Glu Lys His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Phe Asp Phe Asn Lys Gln Ala Ile Arg Arg Leu Lys Ala Pro Ala 
                325                 330                 335     


Gln Met Ser Ile Gln Leu Ile Asn Lys Ala Val Asn Ala Leu Ile Asn 
            340                 345                 350         


Asp Gln Leu Ile Met Lys Asn His Leu Arg Asp Ile Met Gly Ile Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Tyr Trp Tyr Leu Asn His Thr Ile Thr Gly 
    370                 375                 380                 


Lys Thr Ser Leu Pro Lys Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Asp Ile Glu Gln Gln Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Gln Lys Glu Tyr Met Asp Arg Gln Gly Lys Thr 
            420                 425                 430         


Pro Leu Gly Leu Val Asp Leu Phe Val Phe Ser Thr Ser Phe Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Val Gly Lys Pro Cys Pro Lys Pro His Arg Leu Asn His Met Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Leu Tyr Lys Gln Pro Gly Val Pro Val Arg Trp Lys 
                485                 490                 495     


Arg 
    


<210>  22
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-10-FLEP-NtoK

<400>  22
atgggccaga tcgtgacatt cttccaagag gtgccccacg tgatcgaaga agtgatgaac       60

atcgtcctga tcgccctgag cctgctggcc atcctgaagg gcctgtataa tgtggccacc      120

tgtggcctga tcggcctggt cacatttctg ctgctgtgcg gcagaagctg ctccaccaca      180

ctgtataagg gcgtgtacga gctgcaaacc ctggaactga acatggaaac cctgaacatg      240

accatgcctc tgagctgcac caagaacaac agccaccact acatcagagt gggcaacgag      300

acaggcctcg agctgaccct gaccaacacc agcatcatca accacaagtt ctgcaacctg      360

agcgacgccc acaagaagaa cctgtacgat cacgccctga tgagcatcat ctccaccttc      420

cacctgagca tccccaactt caaccagtac gaggccatga gctgcgactt caacggcgga      480

aagatcagcg tgcagtacaa tctgagccac agctatgccg tggacgccgc caatcattgt      540

ggaacagtgg ccaatggcgt gctccagacc ttcatgagaa tggcctgggg cggcagctat      600

atcgccctgg attctggcag aggcaactgg gactgcatca tgaccagcta ccagtacctg      660

atcatccaga acaccacctg ggaagatcac tgccagttca gcagaccctc tcctatcgga      720

tacctgggcc tgctgtccca gagaacccgg gacatctaca tctctggcgg cggaggatct      780

ggcggaggtg gaagtggcac cttcacctgg acactgtctg atagcgaggg caaagagaca      840

cctggcggct actgtctgac ccggtggatg ctgattgagg ccgagctgaa gtgcttcgga      900

aataccgccg tggccaagtg caacgagaag cacgacgagg aattctgcga catgctgcgg      960

ctgttcgatt tcaacaagca ggccatcaga cggctgaagg cccctgctca gatgtccatc     1020

cagctgatca acaaggccgt gaatgccctg attaacgacc agctcatcat gaagaaccac     1080

ctcagggaca tcatgggcat cccttactgc aactacagca agtactggta tctgaaccac     1140

accatcaccg gcaagaccag cctgcctaag tgctggctgg tgtccaacgg cagctacctg     1200

aacgagacac acttcagcga cgacatcgag cagcaggccg acaacatgat caccgagatg     1260

ctccagaaag agtacatgga ccggcagggc aagacacctc tgggccttgt ggatctgttc     1320

gtgttcagca ccagcttcta cctgatctct atcttcctgc acctggtcaa gatccccaca     1380

cacagacaca tcgtgggcaa gccctgtcct aagcctcaca gactgaacca tatgggcatc     1440

tgtagctgcg gcctgtacaa acagcctggc gtgccagtgc ggtggaagag ataa           1494


<210>  23
<211>  569
<212>  PRT
<213>  Artificial Sequnece

<220>
<223>  L-NP-1 = L-NP-CovAnc-1_N

<400>  23

Met Ser Ala Ser Lys Glu Val Lys Ser Phe Leu Trp Thr Gln Ser Leu 
1               5                   10                  15      


Arg Arg Glu Leu Ser Gly Tyr Cys Ser Asn Ile Lys Leu Gln Val Val 
            20                  25                  30          


Lys Asp Ala Gln Ala Leu Leu His Gly Leu Asp Phe Ser Glu Val Ser 
        35                  40                  45              


Asn Val Gln Arg Leu Met Arg Lys Gln Lys Arg Asp Asp Ser Asp Leu 
    50                  55                  60                  


Lys Arg Leu Arg Asp Leu Asn Gln Ala Val Asn Asn Leu Val Glu Leu 
65                  70                  75                  80  


Lys Ser Thr Gln Gln Lys Ser Ile Leu Arg Val Gly Thr Leu Thr Ser 
                85                  90                  95      


Asp Asp Leu Leu Thr Leu Ala Ala Asp Leu Glu Lys Leu Lys Ser Lys 
            100                 105                 110         


Val Ile Arg Thr Glu Arg Pro Leu Ser Ser Gly Val Tyr Met Gly Asn 
        115                 120                 125             


Leu Ser Thr Gln Gln Leu Glu Gln Arg Arg Ala Leu Leu Asn Met Ile 
    130                 135                 140                 


Gly Met Val Gly Gly Ala Gln Gly Thr Gln Pro Gly Arg Asp Gly Val 
145                 150                 155                 160 


Val Arg Val Trp Asp Val Lys Asn Pro Asp Leu Leu Asn Asn Gln Phe 
                165                 170                 175     


Gly Thr Met Pro Ser Leu Thr Leu Ala Cys Leu Thr Lys Gln Gly Gln 
            180                 185                 190         


Val Asp Leu Asn Asp Ala Val Leu Ala Leu Thr Asp Leu Gly Leu Ile 
        195                 200                 205             


Tyr Thr Ala Lys Tyr Pro Asn Ser Ser Asp Leu Asp Arg Leu Ser Gln 
    210                 215                 220                 


Ser His Pro Ile Leu Asn Met Val Asp Thr Lys Lys Ser Ser Leu Asn 
225                 230                 235                 240 


Ile Ser Gly Tyr Asn Phe Ser Leu Gly Ala Ala Val Lys Ala Gly Ala 
                245                 250                 255     


Cys Met Leu Asp Gly Gly Asn Met Leu Glu Thr Ile Lys Val Thr Pro 
            260                 265                 270         


Gln Thr Met Asp Gly Ile Leu Lys Ser Ile Leu Lys Val Lys Lys Ser 
        275                 280                 285             


Leu Gly Met Phe Val Ser Asp Thr Pro Gly Glu Arg Asn Pro Tyr Glu 
    290                 295                 300                 


Asn Ile Leu Tyr Lys Ile Cys Leu Ser Gly Asp Gly Trp Pro Tyr Ile 
305                 310                 315                 320 


Ala Ser Arg Thr Ser Ile Val Gly Arg Ala Trp Glu Asn Thr Thr Val 
                325                 330                 335     


Asp Leu Glu Ser Asp Gly Lys Pro Gln Lys Val Gly Thr Ala Gly Ser 
            340                 345                 350         


Asn Lys Ser Leu Gln Ser Ala Gly Phe Pro Thr Gly Leu Thr Tyr Ser 
        355                 360                 365             


Gln Leu Met Thr Leu Lys Asp Ser Met Met Gln Leu Asp Pro Ser Ala 
    370                 375                 380                 


Lys Thr Trp Ile Asp Ile Glu Gly Arg Pro Glu Asp Pro Val Glu Ile 
385                 390                 395                 400 


Ala Leu Tyr Gln Pro Met Ser Gly Cys Tyr Ile His Phe Phe Arg Glu 
                405                 410                 415     


Pro Thr Asp Leu Lys Gln Phe Lys Gln Asp Ala Lys Tyr Ser His Gly 
            420                 425                 430         


Ile Asp Val Ala Asp Leu Phe Pro Ala Gln Pro Gly Leu Thr Ser Ala 
        435                 440                 445             


Val Ile Glu Ala Leu Pro Arg Asn Met Val Leu Thr Cys Gln Gly Ser 
    450                 455                 460                 


Asp Asp Ile Lys Arg Leu Leu Asp Ser Gln Gly Arg Arg Asp Ile Lys 
465                 470                 475                 480 


Leu Ile Asp Ile Ala Leu Ser Lys Ala Asp Ser Arg Arg Phe Glu Asn 
                485                 490                 495     


Ala Val Trp Asp Gln Cys Lys Asp Leu Cys His Met His Thr Gly Val 
            500                 505                 510         


Val Val Glu Lys Lys Lys Arg Gly Gly Lys Glu Glu Ile Thr Pro His 
        515                 520                 525             


Cys Ala Leu Met Asp Cys Ile Met Tyr Asp Ala Ala Val Ser Gly Gly 
    530                 535                 540                 


Leu Asn Ile Pro Val Leu Arg Ala Val Leu Pro Arg Asp Met Val Phe 
545                 550                 555                 560 


Arg Thr Ser Ser Pro Lys Val Val Leu 
                565                 


<210>  24
<211>  1710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-NP-1 = L-NP-CovAnc-1_N

<400>  24
atgagcgcca gcaaagaagt gaaaagcttc ctctggaccc agagcctgcg gagagagctg       60

tctggctact gctccaacat caagctccag gtggtcaagg acgcccaggc tctgctgcat      120

ggcctggatt tcagcgaggt gtccaacgtg cagcggctga tgagaaagca gaagcgggac      180

gacagcgacc tgaagagact gagggatctg aaccaggccg tgaacaacct ggtggaactg      240

aagtctaccc agcagaaatc catcctgaga gtgggcaccc tgaccagcga cgatctgctg      300

acactggccg ccgatctgga aaagctgaag tccaaagtga tccggaccga gaggccactg      360

tctagcggag tgtacatggg caacctgagc acccagcagc tggaacagag aagggccctg      420

ctgaacatga tcggcatggt tggaggcgcc cagggaacac agcctggaag agatggtgtc      480

gtcagagtgt gggacgtgaa gaaccccgac ctgctcaaca accagttcgg caccatgcct      540

tctctgaccc tggcctgcct gacaaagcag ggccaagtgg acctgaacga tgccgtgctg      600

gctctgactg atctgggcct gatctacacc gccaagtatc ccaacagctc cgacctggac      660

aggctgagcc agtctcaccc catcctgaac atggtggaca ccaagaagtc cagcctgaac      720

atcagcggct acaacttctc tctgggcgct gccgtgaaag ccggcgcttg tatgcttgac      780

ggcggcaaca tgctggaaac catcaaagtg acccctcaga ccatggacgg catcctgaaa      840

agtatcctga aagtgaagaa atccctgggc atgttcgtgt ccgacacacc cggcgagaga      900

aacccctacg agaacatcct gtacaagatt tgcctgagcg gcgacggctg gccctatatc      960

gccagcagaa catctatcgt gggcagagct tgggagaaca ccaccgtgga cctggaatcc     1020

gatggcaagc ctcagaaagt gggcacagcc ggcagcaaca agagcctcca gtctgccgga     1080

tttcctaccg gcctgacata cagccagctg atgaccctga aggacagcat gatgcagctg     1140

gaccctagcg ccaagacctg gatcgacatt gagggcagac ccgaggatcc cgtggaaatc     1200

gctctgtacc agcctatgag cggctgctat atccacttct tcagagagcc caccgatctg     1260

aagcagttca agcaggacgc caagtacagc cacggaatcg acgtggccga tctgttccca     1320

gctcagccag gactgacatc cgccgtgatt gaagccctgc ctagaaacat ggtgctgacc     1380

tgtcagggca gcgacgacat caagagactg ctggacagcc agggcagaag agatatcaag     1440

ctgatcgata tcgccctgag caaggccgac tctcggagat tcgaaaacgc cgtgtgggac     1500

cagtgcaagg acctgtgtca catgcacaca ggcgtggtgg tggaaaagaa gaagcgcgga     1560

ggcaaagagg aaatcacccc tcactgcgcc ctgatggact gcattatgta tgacgccgcc     1620

gtgtctggcg gcctgaatat ccctgttctg agagccgtgc tgccccgcga catggtgttt     1680

agaacaagca gccccaaggt ggtgctctga                                      1710


<210>  25
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-NP-1 = L-NP-CovAnc-2_SL

<400>  25

Met Ser Ala Ser Lys Glu Ile Lys Ser Phe Leu Trp Thr Gln Ser Leu 
1               5                   10                  15      


Arg Arg Glu Leu Ser Gly Tyr Cys Ser Asn Ile Lys Leu Gln Val Val 
            20                  25                  30          


Lys Asp Ala Gln Ala Leu Leu His Gly Leu Asp Phe Ser Glu Val Ser 
        35                  40                  45              


Asn Val Gln Arg Leu Met Arg Lys Glu Arg Arg Asp Asp Asn Asp Leu 
    50                  55                  60                  


Lys Arg Leu Arg Asp Leu Asn Gln Ala Val Asn Asn Leu Val Glu Leu 
65                  70                  75                  80  


Lys Ser Thr Gln Gln Lys Ser Ile Leu Arg Val Gly Thr Leu Thr Ser 
                85                  90                  95      


Asp Asp Leu Leu Ile Leu Ala Ala Asp Leu Glu Lys Leu Lys Ser Lys 
            100                 105                 110         


Val Thr Arg Thr Glu Arg Pro Leu Ser Ala Gly Val Tyr Met Gly Asn 
        115                 120                 125             


Leu Ser Ser Gln Gln Leu Asp Gln Arg Arg Ala Leu Leu Asn Met Ile 
    130                 135                 140                 


Gly Met Ser Gly Gly Asn Gln Gly Ala Arg Ala Gly Arg Asp Gly Val 
145                 150                 155                 160 


Val Arg Val Trp Asp Val Lys Asn Ala Glu Leu Leu Asn Asn Gln Phe 
                165                 170                 175     


Gly Thr Met Pro Ser Leu Thr Leu Ala Cys Leu Thr Lys Gln Gly Gln 
            180                 185                 190         


Val Asp Leu Asn Asp Ala Val Gln Ala Leu Thr Asp Leu Gly Leu Ile 
        195                 200                 205             


Tyr Thr Ala Lys Tyr Pro Asn Thr Ser Asp Leu Asp Arg Leu Thr Gln 
    210                 215                 220                 


Ser His Pro Ile Leu Asn Met Ile Asp Thr Lys Lys Ser Ser Leu Asn 
225                 230                 235                 240 


Ile Ser Gly Tyr Asn Phe Ser Leu Gly Ala Ala Val Lys Ala Gly Ala 
                245                 250                 255     


Cys Met Leu Asp Gly Gly Asn Met Leu Glu Thr Ile Lys Val Ser Pro 
            260                 265                 270         


Gln Thr Met Asp Gly Ile Leu Lys Ser Ile Leu Lys Val Lys Lys Ala 
        275                 280                 285             


Leu Gly Met Phe Ile Ser Asp Thr Pro Gly Glu Arg Asn Pro Tyr Glu 
    290                 295                 300                 


Asn Ile Leu Tyr Lys Ile Cys Leu Ser Gly Asp Gly Trp Pro Tyr Ile 
305                 310                 315                 320 


Ala Ser Arg Thr Ser Ile Thr Gly Arg Ala Trp Glu Asn Thr Val Val 
                325                 330                 335     


Asp Leu Glu Ser Asp Gly Lys Pro Gln Lys Ala Gly Ser Asn Asn Ser 
            340                 345                 350         


Asn Lys Ser Leu Gln Ser Ala Gly Phe Thr Ala Gly Leu Thr Tyr Ser 
        355                 360                 365             


Gln Leu Met Thr Leu Lys Asp Ala Met Leu Gln Leu Asp Pro Asn Ala 
    370                 375                 380                 


Lys Thr Trp Met Asp Ile Glu Gly Arg Pro Glu Asp Pro Val Glu Ile 
385                 390                 395                 400 


Ala Leu Tyr Gln Pro Ser Ser Gly Cys Tyr Ile His Phe Phe Arg Glu 
                405                 410                 415     


Pro Thr Asp Leu Lys Gln Phe Lys Gln Asp Ala Lys Tyr Ser His Gly 
            420                 425                 430         


Ile Asp Val Thr Asp Leu Phe Ala Ala Gln Pro Gly Leu Thr Ser Ala 
        435                 440                 445             


Val Ile Asp Ala Leu Pro Arg Asn Met Val Ile Thr Cys Gln Gly Ser 
    450                 455                 460                 


Asp Asp Ile Arg Lys Leu Leu Glu Ser Gln Gly Arg Lys Asp Ile Lys 
465                 470                 475                 480 


Leu Ile Asp Ile Ala Leu Ser Lys Thr Asp Ser Arg Lys Tyr Glu Asn 
                485                 490                 495     


Ala Val Trp Asp Gln Tyr Lys Asp Leu Cys His Met His Thr Gly Val 
            500                 505                 510         


Val Val Glu Lys Lys Lys Arg Gly Gly Lys Glu Glu Ile Thr Pro His 
        515                 520                 525             


Cys Ala Leu Met Asp Cys Ile Met Phe Asp Ala Ala Val Ser Gly Gly 
    530                 535                 540                 


Leu Asn Thr Ser Val Leu Arg Ala Val Leu Pro Arg Asp Met Val Phe 
545                 550                 555                 560 


Arg Thr Ser Thr Pro Arg Val Val Leu 
                565                 


<210>  26
<211>  1710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-NP-1 = L-NP-CovAnc-2_SL

<400>  26
atgagcgcca gcaaagagat caagagcttc ctgtggaccc agagcctgcg gagagagctg       60

tctggctact gctccaacat caagctccag gtggtcaagg acgcccaggc tctgctgcat      120

ggcctggatt tcagcgaggt gtccaacgtg cagcggctga tgcggaaaga gagaagggac      180

gacaacgacc tgaagcggct gagggatctg aaccaggccg tgaacaacct ggtggaactg      240

aagtctaccc agcagaaatc catcctgaga gtgggcaccc tgaccagcga cgatctgctg      300

attctggccg ccgacctgga aaagctgaag tccaaagtga cccggaccga gaggccactg      360

tctgctggtg tctacatggg caacctgagc agccagcagc tggatcagag aagggccctg      420

ctgaacatga tcggcatgag cggcggaaat cagggcgcta gagctggcag agatggcgtc      480

gtcagagtgt gggacgtgaa gaatgccgag ctgctcaaca accagttcgg caccatgcct      540

agcctgacac tggcctgcct gacaaagcag ggccaagtgg acctgaacga tgctgtgcag      600

gccctgactg atctgggcct gatctacacc gccaagtatc ccaacaccag cgacctggac      660

agactgaccc agtctcaccc catcctgaat atgatcgaca ccaagaagtc cagcctgaac      720

atcagcggct acaacttctc tctgggcgct gccgtgaaag ccggcgcttg tatgcttgac      780

ggcggcaaca tgctggaaac catcaaggtg tccccacaga ccatggacgg catcctgaaa      840

agtatcctga aagtgaagaa agccctgggc atgttcatca gcgacacccc tggcgagaga      900

aacccctacg agaacatcct gtacaagatt tgcctgagcg gcgacggctg gccctatatc      960

gccagcagaa ccagcattac cggcagagct tgggagaaca ccgtggtgga tctggaaagc     1020

gacggcaagc ctcagaaggc cggcagcaac aactccaaca agagcctcca gtccgccggc     1080

ttcacagccg gcctgacata tagccagctg atgaccctga aggacgccat gctgcaactg     1140

gaccccaatg ccaagacctg gatggacatc gagggcagac ctgaggaccc tgtggaaatc     1200

gccctgtacc agcctagctc cggctgctat atccacttct tcagagagcc caccgatctg     1260

aagcagttca agcaggacgc caagtacagc cacggcatcg acgtgaccga tctgtttgct     1320

gctcagcccg gactgacctc cgccgtgatt gatgccctgc ctcggaacat ggtcatcacc     1380

tgtcagggca gcgacgacat ccggaagctg ctggaatctc agggcagaaa ggatatcaag     1440

ctgatcgata tcgccctgag caagaccgac agccggaagt acgaaaacgc cgtgtgggac     1500

cagtacaagg acctgtgcca catgcacaca ggcgtggtgg tggaaaagaa gaagcgcgga     1560

ggcaaagagg aaatcacccc tcactgcgct ctgatggact gcatcatgtt tgacgccgcc     1620

gtgtctggcg gcctgaatac ctctgttctg agagccgtgc tgcccagaga catggtgttc     1680

agaacaagca cccctagagt ggtgctctga                                      1710


