                         SEQUENCE LISTING

<110>  Assistance Publique Hpitaux de Marseille et al.
 
<120>  CD146 and uses thereof as a biomarker and as a therapeutic target
        in the diagnosis and treatment of fibrosis

<130>  B2850PC00

<160>  102   

<170>  PatentIn version 3.5

<210>  1
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu 
545                 550         


<210>  2
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro 
545                 550             


<210>  3
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu 
545                 550                 


<210>  4
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro 
545                 550                 555 


<210>  5
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu 
545                 550                 555     


<210>  6
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser 
545                 550                 555         


<210>  7
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser Arg 
545                 550                 555             


<210>  8
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Tyr Ile Val Arg Gln Phe Leu Leu Tyr Asn Val Ser Gly Ser 
1               5                   10                  15      


Val Tyr Leu Asp Gln Leu Ile Val Leu Leu Thr Ala Lys Phe Ser Ile 
            20                  25                  30          


Leu Arg Ile Ala Gly Ser Arg Val His His Ser Pro Phe Ser Gly His 
        35                  40                  45              


Leu Asp Gly Cys Ser Phe Leu Ser Leu Gln His Ser Leu His Thr Ser 
    50                  55                  60                  


Leu Asp Met Ser Arg His Glu Asn Val Phe Leu Gly Leu Thr Leu Ser 
65                  70                  75                  80  


Ser Lys Ser Ala Gly Leu Lys Gly Phe Gln Leu Ala Phe Val Pro Gly 
                85                  90                  95      


Leu Leu Gln Gly Thr Gly Gly Tyr Leu Asp Gly Pro Leu Pro Thr Pro 
            100                 105                 110         


Val Asp Asn Pro Arg Val Gly Leu Glu Val Gly Leu Arg Leu Ser Leu 
        115                 120                 125             


Pro Pro Leu Pro Pro Cys Pro Gly Val His Ile Gln Ser Ser Gln Thr 
    130                 135                 140                 


Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu Lys Ala Gln 
145                 150                 155                 160 


Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu Leu Asn Tyr 
                165                 170                 175     


Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu Val Thr Val 
            180                 185                 190         


Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val Glu Pro Val 
        195                 200                 205             


Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys Leu Ala Asp 
    210                 215                 220                 


Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn Pro Ser Thr 
225                 230                 235                 240 


Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val Leu Val Leu 
                245                 250                 255     


Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys Gln Gly Leu 
            260                 265                 270         


Asp Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln Glu Leu Leu 
        275                 280                 285             


Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala Pro Glu Arg 
    290                 295                 300                 


Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu Ser Ser Gln 
305                 310                 315                 320 


Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Gly Gln Val Leu Glu 
                325                 330                 335     


Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu Ala Gly Gly 
            340                 345                 350         


Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly Leu Asn Arg 
        355                 360                 365             


Thr Gln Leu Val Asn Val Ala Ile Phe Gly Pro Pro Trp Met Ala Phe 
    370                 375                 380                 


Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu Asn Leu Ser 
385                 390                 395                 400 


Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp Asn Val Asn 
                405                 410                 415     


Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val Leu Ser Thr 
            420                 425                 430         


Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly Val Glu Cys 
        435                 440                 445             


Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu Phe Leu Glu 
    450                 455                 460                 


Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr Thr Thr Gly 
465                 470                 475                 480 


Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn Ser Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Gly Leu Ala Arg Glu Gln Gly Cys Ala Arg Ala Ser 
            500                 505                 510         


Phe Leu Pro Cys Pro Ser Pro Glu Ser Pro Val Gln Lys Gly Glu 
        515                 520                 525         


<210>  9
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Gly Leu Asp Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Gly Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Asn Val Ala Ile Phe Gly Glu Ala Leu 
            420                 425                 430         


Pro Leu Gly Arg Asp Gln Val Thr Pro Ser Gly Val Val Phe Lys Leu 
        435                 440                 445             


Phe Asp Lys Lys Pro Pro Ala Ala Leu Gly Ser Ser Gly Ala Glu Gly 
    450                 455                 460                 


Glu Ala Gly 
465         


<210>  10
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser Arg Gly Val 
545                 550                 555                 560 


Val Ile Val Ala Val Ile Val Cys Ile Leu Val Leu Ala Val Leu Gly 
                565                 570                 575     


Ala Val Leu Tyr Phe Leu Tyr Lys Lys Gly Lys Leu Pro Cys Arg Arg 
            580                 585                 590         


Ser Gly Lys Gln Glu Ile Thr Leu Pro Pro Ser Arg Lys Thr Glu Leu 
        595                 600                 605             


Val Val Glu Val Lys Ser Asp Lys Leu Pro Glu Glu Met Gly Leu Leu 
    610                 615                 620                 


Gln Gly Ser Ser Gly Asp Lys Arg Ala Pro Gly Asp Gln Gly Glu Lys 
625                 630                 635                 640 


Tyr Ile Asp Leu Arg His 
                645     


<210>  11
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser Arg Gly Val 
545                 550                 555                 560 


Val Ile Val Ala Val Ile Val Cys Ile Leu Val Leu Ala Val Leu Gly 
                565                 570                 575     


Ala Val Leu Tyr Phe Leu Tyr Lys Lys Gly Lys Leu Pro Cys Arg Arg 
            580                 585                 590         


Ser Gly Lys Gln Glu Met Glu Arg Asn Thr Ser Ile 
        595                 600                 


<210>  12
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  12
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctg                               1656


<210>  13
<211>  1659
<212>  DNA
<213>  Homo sapiens

<400>  13
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccg                            1659


<210>  14
<211>  1662
<212>  DNA
<213>  Homo sapiens

<400>  14
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg ag                        1662


<210>  15
<211>  1665
<212>  DNA
<213>  Homo sapiens

<400>  15
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccg                     1665


<210>  16
<211>  1668
<212>  DNA
<213>  Homo sapiens

<400>  16
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccggag                  1668


<210>  17
<211>  1671
<212>  DNA
<213>  Homo sapiens

<400>  17
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccggagag c              1671


<210>  18
<211>  1674
<212>  DNA
<213>  Homo sapiens

<400>  18
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccggagag ccgg           1674


<210>  19
<211>  1584
<212>  DNA
<213>  Homo sapiens

<400>  19
atggtataca ttgttagaca atttctttta tacaatgttt ctgggtcagt ctatttagat       60

caactgatcg ttttgcttac tgccaagttt tccatactac gcatagcagg tagtcgagtt      120

caccattccc catttagtgg acatctagac ggctgctcgt ttttatcatt gcagcattct      180

ttgcacacat ccttggatat gagcagacat gaaaatgttt ttctagggtt gacactgagc      240

agtaaaagtg ctgggttgaa gggtttccag cttgcatttg tacctggcct tctacagggg      300

acagggggct atttagatgg tcccctgcca accccagtgg acaaccctag ggtggggctg      360

gaggtggggc tgaggctgag tcttcctccc cttcctccct gcccaggggt ccacattcag      420

tcgtcccaga ctgtggagtc gagtggtttg tacaccttgc agagtattct gaaggcacag      480

ctggttaaag aagacaaaga tgcccagttt tactgtgagc tcaactaccg gctgcccagt      540

gggaaccaca tgaaggagtc cagggaagtc accgtccctg ttttctaccc gacagaaaaa      600

gtgtggctgg aagtggagcc cgtgggaatg ctgaaggaag gggaccgcgt ggaaatcagg      660

tgtttggctg atggcaaccc tccaccacac ttcagcatca gcaagcagaa ccccagcacc      720

agggaggcag aggaagagac aaccaacgac aacggggtcc tggtgctgga gcctgcccgg      780

aaggaacaca gtgggcgcta tgaatgtcag ggcctggact tggacaccat gatatcgctg      840

ctgagtgaac cacaggaact actggtgaac tatgtgtctg acgtccgagt gagtcccgca      900

gcccctgaga gacaggaagg cagcagcctc accctgacct gtgaggcaga gagtagccag      960

gacctcgagt tccagtggct gagagaagag acaggccagg tgctggaaag ggggcctgtg     1020

cttcagttgc atgacctgaa acgggaggca ggaggcggct atcgctgcgt ggcgtctgtg     1080

cccagcatac ccggcctgaa ccgcacacag ctggtcaacg tggccatttt tggcccccct     1140

tggatggcat tcaaggagag gaaggtgtgg gtgaaagaga atatggtgtt gaatctgtct     1200

tgtgaagcgt cagggcaccc ccggcccacc atctcctgga acgtcaacgg cacggcaagt     1260

gaacaagacc aagatccaca gcgagtcctg agcaccctga atgtcctcgt gaccccggag     1320

ctgttggaga caggtgttga atgcacggcc tccaacgacc tgggcaaaaa caccagcatc     1380

ctcttcctgg agctggtcaa tttaaccacc ctcacaccag actccaacac aaccactggc     1440

ctcagcactt ccactgccag tcctcatacc agagccaaca gcacctccac aggtaagcca     1500

ggcctggcaa gagaacaggg ctgtgccagg gcatcctttc tgccctgtcc ctccccagag     1560

agccctgtcc agaaaggtga gtag                                            1584


<210>  20
<211>  1403
<212>  DNA
<213>  Homo sapiens

<400>  20
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggtgag gccctccctc tgggtagaga ccaggtcacc     1320

ccaagtgggt ggtttttaag ctctttgaca aaaagccacc tgctgccctg gggagctctg     1380

gtgcggaggg ggaggcaggc tag                                             1403


<210>  21
<211>  1815
<212>  DNA
<213>  Homo sapiens

<400>  21
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccggagag ccggggcgtg     1680

gtcatcgtgg ctgtgattgt gtgcatcctg gtcctggcgg tgctgggcgc tgtcctctat     1740

ttcctctata agaagggcaa gctgccgtgc aggagctcag ggaagcagga gatggagaga     1800

aatacatcga tctga                                                      1815


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  22
tcacttgaca gtgtgatggt                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  23
ccttagaaag cagggattca                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  24
cccaaatcct ctggaagaca                                                   20


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  25
tgtaatgaaa gacggcacac c                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  26
tcttctttgg gtattgcttg g                                                 21


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  27
tcttctcatt cctgcttgtg g                                                 21


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  28
atgagaggga ggccatttg                                                    19


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  29
cccacgctac ctctgctc                                                     18


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  30
gatggatacc tgagcatcac c                                                 21


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  31
tggagcaaca tgtggaactc                                                   20


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  32
gtcagcagcc ggttacca                                                     18


<210>  33
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  33
tggtttcttc tcacccttct tc                                                22


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  34
tgcatcccaa ttcatctacg t                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  35
tccagtcatc acagattgtc g                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  36
aaacagggac agtgacctcc t                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  37
tggtgaaatg gaatctgaac c                                                 21


<210>  38
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  38
cccagatggt ttcctt                                                       16


<210>  39
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  39
catccacgtg ttggctca                                                     18


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  40
gatcatcttg ctggtgaatg agt                                               23


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  41
gcaggttcac ctactctgtc ct                                                22


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  42
cttgccccat tcatttgtct                                                   20


<210>  43
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
ggagcggtag cacctcct                                                     18


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  44
ctggttcatc atcgctaatc ac                                                22


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  45
caatcacctg cgtacagaa                                                    19


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  46
ttctgtacgc aggtgattg                                                    19


<210>  47
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  47
ggcatagagg gagagcac                                                     18


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  48
ttcggggaga ggtgatgttc                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  49
gtgctaaagg tggcaarggt                                                   20


<210>  50
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  50
accaggttca ccgctac                                                      17


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  51
attgcccaat tgagtgcttc                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  52
tgatgcttgg agaagctgtg                                                   20


<210>  53
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  53
gagctattgt aatgaccagt caacaggg                                          28


<210>  54
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  54
ggattatact gcctgaccaa ggaaagc                                           27


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH forward primer

<400>  55
ggtggtctcc tgacttcaac a                                                 21


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH reverse primer

<400>  56
gttgctgtag ccaattcgtt gt                                                22


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD146sh forward primer

<400>  57
ccactggcct cagcacttcc                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD146sh reverse primer

<400>  58
ctactcacct ttctggacag                                                   20


<210>  59
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD146lg forward primer

<400>  59
tggtttgtac accttgcaga gtattc                                            26


<210>  60
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD146lg reverse primer

<400>  60
tgggcagccg gtagttg                                                      17


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MT1MMP forward sequence

<400>  61
tagcgcttcc ttcgaacatt                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MT1MMP reverse primer

<400>  62
gcagaagttt tacggcttgc                                                   20


<210>  63
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP2 forward sequence

<400>  63
tgatcttgac cagaatacca tcga                                              24


<210>  64
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP2 reverse sequence

<400>  64
ggcttgcgag gaagaagtt                                                    19


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tace forward sequence

<400>  65
gcattctcaa gtctccacaa g                                                 21


<210>  66
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tace reverse sequence

<400>  66
ctgggagagc caactaagc                                                    19


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADAM10 forward sequence

<400>  67
cagagtgcac accaggagaa                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADAM10 reverse sequence

<400>  68
cccaggtttc agtttgcatt                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I10-sCD146 forward primer

<400>  69
ggcagaggaa gagacaacca                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I10-sCD146 reverse primer

<400>  70
ttggggtgac ctggtctcta                                                   20


<210>  71
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I5-13-sCD146 forward primer

<400>  71
ggacatctag acggtgctc                                                    19


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I5-13-sCD146 reverse primer

<400>  72
acaaatgcaa gctggaaacc                                                   20


<210>  73
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siTACE sens siRNA

<400>  73
caggauuuaa agguuaugga a                                                 21


<210>  74
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siTACE antisens siRNA

<400>  74
uuccauaaac cuuuaaaucc ug                                                22


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siADAM10 sens siRNA

<400>  75
gaaugguaga acaaggugat t                                                 21


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siADAM10 antisens siRNA

<400>  76
ucaccuuguu cuaccauucc a                                                 21


<210>  77
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siMT1MMP sens siRNA

<400>  77
gcgaugaagu cuucacuuad tdt                                               23


<210>  78
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siMT1MMP antisens siRNA

<400>  78
uaagugaaga cuucaucgc                                                    19


<210>  79
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sishCD146 sens siRNA

<400>  79
caggagaugg agagaaauac aucga                                             25


<210>  80
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sishCD146 antisens siRNA

<400>  80
ucgauguauu ucucuccauc uccug                                             25


<210>  81
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  silgCD146 sens siRNA

<400>  81
cccgucucgu aagaccgaac uugua                                             25


<210>  82
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  silgCD146 antisens siRNA

<400>  82
uacaaguucg gucuuacgag acggg                                             25


<210>  83
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siI10-sCD146 sens siRNA

<400>  83
cccucccucu ggguagagac caggu                                             25


<210>  84
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siI10-sCD146 antisens siRNA

<400>  84
accuggucuc uacccagagg gaggg                                             25


<210>  85
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siI5-13-sCD146 sens siRNA

<400>  85
uggacaucua gacggcugcu cguuu                                             25


<210>  86
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siI5-13-sCD146 antisens siRNA

<400>  86
aaacgagcag ccgucuagau gucca                                             25


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26D12-7 CDR1

<400>  87

Gly Tyr Thr Phe Thr Ser His Phe 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26D12-7 CDR2

<400>  88

Ile Phe Pro Gly Ser Gly Asp Thr 
1               5               


<210>  89
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26D12-7 CDR3

<400>  89

Ala Arg Thr Trp Ala Tyr 
1               5       


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26D12-7 CDR4

<400>  90

Gln Ser Leu Leu Tyr Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26D12-7 CDR6

<400>  91

Ala Gln Thr Thr His Phe Pro Leu Thr 
1               5                   


<210>  92
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26D12-7 variable heavy chain

<400>  92

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Phe Val His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Asp Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  93
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26D12-7 light variable chain

<400>  93

Asp Val Val Met Thr Gln Thr Pro Pro Ser Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Ser Val Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu His Trp Leu Leu Gln Ser Ser Gly Arg Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Gln Val Ser Asn Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Thr Gly Ser Gln Lys Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Lys Asp Leu Gly Val Tyr Tyr Cys Ala Gln Thr 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B9-4 CDR1

<400>  94

Gly Phe Thr Phe Ser Asp Tyr Gly 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B9-4 CDR2

<400>  95

Ile Tyr Tyr Asp Ser Ser Lys Met 
1               5               


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B9-4 CDR3

<400>  96

Ala Ala Phe Gln Phe Asp Tyr 
1               5           


<210>  97
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B9-4 CDR4

<400>  97

Gln Gly Ile Ser Thr Ser 
1               5       


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B9-4 CDR6

<400>  98

Gln Gln Ser Tyr Asn Leu Pro Tyr Thr 
1               5                   


<210>  99
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B9-4 variable heavy chain

<400>  99

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Ile Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Met Ile Tyr Tyr Asp Ser Ser Lys Met Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Gln Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  100
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B9-4 variable light chain

<400>  100

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Thr Ser 
            20                  25                  30          


Ile Tyr Trp Tyr Gln Gln Lys Ser Asn Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Arg Val Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ser Val Tyr Tyr Cys Gln Gln Ser Tyr Asn Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  101
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  101

Tyr Leu Asp Gly Pro Leu Pro Thr Pro Val Asp Asn Pro Arg 
1               5                   10                  


<210>  102
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  102

Arg Asp Gln Val Thr Pro Ser Gly Val Val Phe Lys Leu Phe Asp Lys 
1               5                   10                  15      


Lys Pro 
        


