               SEQUENCE LISTING

<110> Institut National de la Sante et de la Recherche Medicale (INSERM)
      Institut National de la Recherche Agronomique (INRA)

<120> USE OF MAM POLYPEPTIDES FOR THE TREATMENT OF OBESITY AND OBESITY-RELATED DISORDERS

<130> BIO18253

<150> EP18306245
<151> 2018-09-25

<160> 39

<170> BiSSAP 1.3.6

<210> 1
<211> 166
<212> PRT
<213> Artificial Sequence


<220> 
<223> consensus sequence

<220> 
<221> VAR_SEQ
<222> 7..7
<223> X = Phe or Tyr

<220> 
<221> VAR_SEQ
<222> 8..8
<223> X = Ser or Thr

<220> 
<221> VAR_SEQ
<222> 9..9
<223> X = Ala or Val

<220> 
<221> VAR_SEQ
<222> 10..10
<223> X = Val or Ile

<220> 
<221> VAR_SEQ
<222> 11..11
<223> X = Ser, Ala or Asn

<220> 
<221> VAR_SEQ
<222> 12..12
<223> X = Glu or no amino acid

<220> 
<221> VAR_SEQ
<222> 13..13
<223> X = Asn or no amino acid

<220> 
<221> VAR_SEQ
<222> 14..14
<223> X = Glu or no amino acid

<220> 
<221> VAR_SEQ
<222> 15..15
<223> X = Met, Ser or Ala

<220> 
<221> VAR_SEQ
<222> 16..16
<223> X = Thr or Glu

<220> 
<221> VAR_SEQ
<222> 17..17
<223> X = Tyr or Val

<220> 
<221> VAR_SEQ
<222> 19..19
<223> X = Met, Val, Asn or Tyr

<220> 
<221> VAR_SEQ
<222> 22..22
<223> X = Ser or Ala

<220> 
<221> VAR_SEQ
<222> 23..23
<223> X = Asn, Asp or no amino acid

<220> 
<221> VAR_SEQ
<222> 24..24
<223> X = Phe, Leu or no amino acid

<220> 
<221> VAR_SEQ
<222> 25..25
<223> Xaa can be any naturally occurring amino acid

<220> 
<221> VAR_SEQ
<222> 26..26
<223> X = Asp, Thr or no amino acid

<220> 
<221> VAR_SEQ
<222> 27..27
<223> X = Ala, Ile or no amino acid

<220> 
<221> VAR_SEQ
<222> 28..28
<223> X = Val, Leu or Ile

<220> 
<221> VAR_SEQ
<222> 29..29
<223> X = Ala, Val or Gly

<220> 
<221> VAR_SEQ
<222> 30..30
<223> X = Ala or Asp

<220> 
<221> VAR_SEQ
<222> 31..31
<223> X = Thyr, Val or Thr

<220> 
<221> VAR_SEQ
<222> 32..32
<223> X = Leu or Thr

<220> 
<221> VAR_SEQ
<222> 33..33
<223> X = Ala or Pro

<220> 
<221> VAR_SEQ
<222> 34..34
<223> X = Pro or Ser

<220> 
<221> VAR_SEQ
<222> 35..35
<223> X = Ala or Ile

<220> 
<221> VAR_SEQ
<222> 36..36
<223> X = Met or Trp

<220> 
<221> VAR_SEQ
<222> 37..37
<223> X = Gly, Thr or Asn

<220> 
<221> VAR_SEQ
<222> 38..38
<223> X = Ala, Thr or Leu

<220> 
<221> VAR_SEQ
<222> 39..39
<223> X = Ala, Asp, or Glu

<220> 
<221> VAR_SEQ
<222> 40..40
<223> X = Gln, Asn, or Ser

<220> 
<221> VAR_SEQ
<222> 41..41
<223> X = Trp or Val

<220> 
<221> VAR_SEQ
<222> 42..42
<223> X = Asn, Thr, Lys or Arg

<220> 
<221> VAR_SEQ
<222> 43..43
<223> X = Asn, Thr, Lys, or Arg

<220> 
<221> VAR_SEQ
<222> 44..44
<223> X = Phe or Val

<220> 
<221> VAR_SEQ
<222> 45..45
<223> X = His, Ser or Asn

<220> 
<221> VAR_SEQ
<222> 46..46
<223> X = Lys, Ala, Thr or Ser

<220> 
<221> VAR_SEQ
<222> 48..48
<223> X = Leu, Val or Ile

<220> 
<221> VAR_SEQ
<222> 49..49
<223> X = Ile or Val

<220> 
<221> VAR_SEQ
<222> 50..50
<223> X = Thr or Lys

<220> 
<221> VAR_SEQ
<222> 51..51
<223> X = Ile or Leu

<220> 
<221> VAR_SEQ
<222> 52..52
<223> X = Val or Ile

<220> 
<221> VAR_SEQ
<222> 53..53
<223> X = Gly or Ser

<220> 
<221> VAR_SEQ
<222> 55..55
<223> X = Lys, Ser or Thr

<220> 
<221> VAR_SEQ
<222> 56..56
<223> X = Tyr or Phe

<220> 
<221> VAR_SEQ
<222> 57..57
<223> X = Val, Leu, Phe or Tyr

<220> 
<221> VAR_SEQ
<222> 58..58
<223> X = Gln, ala, Lys or Ser

<220> 
<221> VAR_SEQ
<222> 59..59
<223> X = Gly, Lys; Ser or His

<220> 
<221> VAR_SEQ
<222> 60..60
<223> X = Phe, Tyr, Thr or Leu

<220> 
<221> VAR_SEQ
<222> 61..61
<223> X = Leu, Thr, Ile or Val

<220> 
<221> VAR_SEQ
<222> 62..62
<223> X = Asp, Asn, Ser or Lys

<220> 
<221> VAR_SEQ
<222> 63..63
<223> X = Asn, Asp, Arg or Ala

<220> 
<221> VAR_SEQ
<222> 64..64
<223> X = Thr or Val

<220> 
<221> VAR_SEQ
<222> 65..65
<223> X = Gly or Ala

<220> 
<221> VAR_SEQ
<222> 66..66
<223> X = Gly or Ala

<220> 
<221> VAR_SEQ
<222> 67..67
<223> X = Ala, Gln, Val or Thr

<220> 
<221> VAR_SEQ
<222> 68..68
<223> X = Val, Met or Leu

<220> 
<221> VAR_SEQ
<222> 70..70
<223> X = Ser, Asp or Gly

<220> 
<221> VAR_SEQ
<222> 72..72
<223> X = Thr, Asn or Ser

<220> 
<221> VAR_SEQ
<222> 73..73
<223> X = Trp, Tyr or no amino acid

<220> 
<221> VAR_SEQ
<222> 74..74
<223> X = Thr, Val or Gly

<220> 
<221> VAR_SEQ
<222> 75..75
<223> X = Pro, Thr, Lys or Ser

<220> 
<221> VAR_SEQ
<222> 76..76
<223> X = Gly, Trp or Asp

<220> 
<221> VAR_SEQ
<222> 77..77
<223> X = Asp, Lys or Gly

<220> 
<221> VAR_SEQ
<222> 78..78
<223> X = Gly, Glu, Asp, Val or no amino acid

<220> 
<221> VAR_SEQ
<222> 79..79
<223> X = Leu, Val, Lys or Thr

<220> 
<221> VAR_SEQ
<222> 80..80
<223> X = Thr, Ile, Gly or Leu

<220> 
<221> VAR_SEQ
<222> 81..81
<223> X = Gly, Asn or Phe

<220> 
<221> VAR_SEQ
<222> 82..82
<223> X = Phe, Tyr, Ile or Gly

<220> 
<221> VAR_SEQ
<222> 83..83
<223> X = Gly, Ser, Glu or Asp

<220> 
<221> VAR_SEQ
<222> 84..84
<223> X = Gly or no amino acid

<220> 
<221> VAR_SEQ
<222> 85..85
<223> X = Gln or no amino acid

<220> 
<221> VAR_SEQ
<222> 86..86
<223> X = Phe or no amino acid

<220> 
<221> VAR_SEQ
<222> 87..87
<223> X = Ser, Val or no amino acid

<220> 
<221> VAR_SEQ
<222> 88..88
<223> X = Lys, Thr or no amino acid

<220> 
<221> VAR_SEQ
<222> 89..89
<223> X = Ile, Asn or no amino acid

<220> 
<221> VAR_SEQ
<222> 90..90
<223> X = Trp, Leu or no amino acid

<220> 
<221> VAR_SEQ
<222> 91..91
<223> X = Lys, Asp, Glu or Asn

<220> 
<221> VAR_SEQ
<222> 92..92
<223> X = Asp, Lys, Asn or Gly

<220> 
<221> VAR_SEQ
<222> 93..93
<223> X = Asn, Ala, Leu, Ser or Thr

<220> 
<221> VAR_SEQ
<222> 94..94
<223> X = Tyr, Phe or Ile

<220> 
<221> VAR_SEQ
<222> 95..95
<223> X = Thr, Asn, Gly or Ser

<220> 
<221> VAR_SEQ
<222> 96..96
<223> X = Asp, Thr, Gln or no amino acid

<220> 
<221> VAR_SEQ
<222> 97..97
<223> X = Asn or no amino acid

<220> 
<221> VAR_SEQ
<222> 98..98
<223> X = Val or no amino acid

<220> 
<221> VAR_SEQ
<222> 99..99
<223> Xaa can be any naturally occurring amino acid

<220> 
<221> VAR_SEQ
<222> 100..100
<223> X = Gly or Asp

<220> 
<221> VAR_SEQ
<222> 101..101
<223> X = Glu, Tyr, Asn or Leu

<220> 
<221> VAR_SEQ
<222> 102..102
<223> X = Ser, Gly, Pro, Trp or Tyr

<220> 
<221> VAR_SEQ
<222> 103..103
<223> X = Thr, Ile or Asn

<220> 
<221> VAR_SEQ
<222> 104..104
<223> X = Gly, Phe, Glu, Asp or Val

<220> 
<221> VAR_SEQ
<222> 105..105
<223> X = Ala, Gly, Lys, Asp or Asn

<220> 
<221> VAR_SEQ
<222> 106..106
<223> X = Gln, Gly, Asn, His or Arg

<220> 
<221> VAR_SEQ
<222> 107..107
<223> X = Lys, Asn, Thr or Leu

<220> 
<221> VAR_SEQ
<222> 108..108
<223> X = Phe, Trp, Thr or Pro

<220> 
<221> VAR_SEQ
<222> 109..109
<223> X = Gly or Arg

<220> 
<221> VAR_SEQ
<222> 110..110
<223> X = Tyr, Phe, Asp, Thr or Gly

<220> 
<221> VAR_SEQ
<222> 111..111
<223> X = Gly, Tyr, Asp, Glu or no amino acid

<220> 
<221> VAR_SEQ
<222> 112..112
<223> X = Ala or Asp

<220> 
<221> VAR_SEQ
<222> 113..113
<223> X = Leu, Val, Met or Gln

<220> 
<221> VAR_SEQ
<222> 114..114
<223> X = Gly, Asn or Thr

<220> 
<221> VAR_SEQ
<222> 115..115
<223> X = Val, Ala or Phe

<220> 
<221> VAR_SEQ
<222> 116..116
<223> X = Val, Leu or Gly

<220> 
<221> VAR_SEQ
<222> 117..117
<223> X = Asn or no amino acid

<220> 
<221> VAR_SEQ
<222> 118..118
<223> X = Ser, Ala, Lys or no amino acid

<220> 
<221> VAR_SEQ
<222> 119..119
<223> X = Ile, Gly, Val, or no amino acid

<220> 
<221> VAR_SEQ
<222> 120..120
<223> X = Leu, Met or no amino acid

<220> 
<221> VAR_SEQ
<222> 121..121
<223> X = Asn, Gln, Thr or no amino acid

<220> 
<221> VAR_SEQ
<222> 122..122
<223> X = Val, Ile, Thr or no amino acid

<220> 
<221> VAR_SEQ
<222> 123..123
<223> X = Ala, Leu or no amino acid

<220> 
<221> VAR_SEQ
<222> 125..125
<223> X = As, Gly, Ile, Met or Leu

<220> 
<221> VAR_SEQ
<222> 126..126
<223> X = Leu or Ala

<220> 
<221> VAR_SEQ
<222> 127..127
<223> X = Ala or Ser

<220> 
<221> VAR_SEQ
<222> 128..128
<223> X = Ala or Val

<220> 
<221> VAR_SEQ
<222> 129..129
<223> X = Ile, Val or Gly

<220> 
<221> VAR_SEQ
<222> 131..131
<223> X = Asn or Thr

<220> 
<221> VAR_SEQ
<222> 134..134
<223> X = Phe, ser, Val, Thr or Met

<220> 
<221> VAR_SEQ
<222> 135..135
<223> X = Gly, Ser, Ala, Thr or Lys

<220> 
<221> VAR_SEQ
<222> 136..136
<223> X = Thr, Ser, Pro or Asp

<220> 
<221> VAR_SEQ
<222> 137..137
<223> X = Ala, Ile or Thr

<220> 
<221> VAR_SEQ
<222> 138..138
<223> X = Lys, Gly, or Ala

<220> 
<221> VAR_SEQ
<222> 139..139
<223> X = Asn, Leu or Val

<220> 
<221> VAR_SEQ
<222> 140..140
<223> X = Ile, Glu, Thr, Gly or Leu

<220> 
<221> VAR_SEQ
<222> 141..141
<223> X = Val, Thr or Phe

<220> 
<221> VAR_SEQ
<222> 142..142
<223> X = Gly, Lys, Asn or Ala

<220> 
<221> VAR_SEQ
<222> 143..143
<223> X = Glu, Ser, Asp or Lys

<220> 
<221> VAR_SEQ
<222> 144..144
<223> X = Gly, Thr or Lys

<220> 
<221> VAR_SEQ
<222> 145..145
<223> X = Val, Thr or Glu

<220> 
<221> VAR_SEQ
<222> 146..146
<223> X = Tyr, Leu, Val or Thr

<220> 
<221> VAR_SEQ
<222> 147..147
<223> X = Lys, Pro, Gly or Asn

<220> 
<221> VAR_SEQ
<222> 148..148
<223> X = Ala, Thr, Phe, Ile or Ser

<220> 
<221> VAR_SEQ
<222> 149..149
<223> X = Leu, Thr, Asn or no amino acid

<220> 
<221> VAR_SEQ
<222> 150..150
<223> X = Val, Gly or no amino acid

<220> 
<221> VAR_SEQ
<222> 151..151
<223> X = Lys, Gln or no amino acid

<220> 
<221> VAR_SEQ
<222> 152..152
<223> X = Leu, Val or no amino acid

<220> 
<221> VAR_SEQ
<222> 153..153
<223> X = Trp or no amino acid

<220> 
<221> VAR_SEQ
<222> 154..154
<223> X = Gly or no amino acid

<220> 
<221> VAR_SEQ
<222> 155..155
<223> X = Asp or no amino acid

<220> 
<221> VAR_SEQ
<222> 156..156
<223> X = Leu or no amino acid

<220> 
<221> VAR_SEQ
<222> 157..157
<223> X = Pro or no amino acid

<220> 
<221> VAR_SEQ
<222> 158..158
<223> X = Asn or no amino acid

<220> 
<221> VAR_SEQ
<222> 159..159
<223> X = Asn or no amino acid

<220> 
<221> VAR_SEQ
<222> 160..160
<223> X = Gly or no amino acid

<220> 
<221> VAR_SEQ
<222> 161..161
<223> X = Gly or no amino acid

<220> 
<221> VAR_SEQ
<222> 162..162
<223> X = Ser or no amino acid

<220> 
<221> VAR_SEQ
<222> 163..163
<223> X = Gly or no amino acid

<220> 
<221> VAR_SEQ
<222> 164..164
<223> X = Trp or no amino acid

<220> 
<221> VAR_SEQ
<222> 165..165
<223> X = Val or no amino acid

<220> 
<221> VAR_SEQ
<222> 166..166
<223> X = Gly or no amino acid

<400> 1
Met Met Met Pro Ala Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      
Xaa Val Xaa Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa 
        35                  40                  45              
Xaa Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  
Xaa Xaa Xaa Xaa Phe Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
        115                 120                 125             
Xaa Tyr Xaa Leu Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 
Xaa Xaa Xaa Xaa Xaa Xaa 
                165     

<210> 2
<211> 135
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 2
Met Met Met Pro Ala Asn Tyr Ser Val Ile Ala Glu Asn Glu Met Thr 
1               5                   10                  15      
Tyr Val Asn Gly Gly Ala Asn Phe Ile Asp Ala Ile Gly Ala Val Thr 
            20                  25                  30          
Ala Pro Ile Trp Thr Leu Asp Asn Val Lys Thr Phe Asn Thr Asn Ile 
        35                  40                  45              
Val Thr Leu Val Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr 
    50                  55                  60                  
Ile Gly Val Leu Phe Ser Gly Asn Thr Thr Trp Lys Glu Val Gly Asn 
65                  70                  75                  80  
Ile Gly Lys Asn Leu Phe Gly Thr Asn Val Lys Gly Asn Pro Ile Glu 
                85                  90                  95      
Lys Asn Asn Phe Gly Asp Tyr Ala Met Asn Ala Leu Gly Ile Ala Ala 
            100                 105                 110         
Ala Val Tyr Asn Leu Gly Val Ala Pro Thr Lys Asn Thr Val Lys Glu 
        115                 120                 125             
Thr Glu Val Lys Phe Thr Val 
    130                 135 

<210> 3
<211> 143
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 3
Met Met Met Pro Ala Asn Phe Ser Ala Val Ser Glu Asn Glu Met Thr 
1               5                   10                  15      
Tyr Val Met Gly Gly Ser Val Ala Asp Tyr Leu Ala Pro Ala Met Gly 
            20                  25                  30          
Ala Ala Gln Trp Gln Asn Phe His Lys Asn Leu Ile Thr Ile Val Gly 
        35                  40                  45              
Asn Lys Tyr Val Gln Gly Phe Leu Asp Asn Thr Val Gly Ala Val Phe 
    50                  55                  60                  
Ser Gly Thr Trp Thr Pro Gly Asp Gly Leu Thr Gly Phe Gly Gly Gln 
65                  70                  75                  80  
Phe Ser Lys Ile Trp Lys Asp Asn Tyr Thr Asp Asn Val Thr Gly Glu 
                85                  90                  95      
Ser Thr Gly Ala Gln Lys Phe Gly Tyr Gly Ala Leu Gly Val Val Asn 
            100                 105                 110         
Ser Ile Leu Asn Val Ala Gly Asn Leu Ala Ala Ile Tyr Asn Leu Gly 
        115                 120                 125             
Phe Gly Thr Ala Lys Asn Ile Val Gly Glu Gly Val Tyr Lys Ala 
    130                 135                 140             

<210> 4
<211> 143
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 4
Met Met Met Pro Ala Asn Phe Ser Ala Val Ser Glu Asn Glu Met Thr 
1               5                   10                  15      
Tyr Val Met Gly Gly Ser Val Ala Asp Tyr Leu Ala Pro Ala Met Gly 
            20                  25                  30          
Ala Ala Gln Trp Gln Asn Phe His Lys Asn Leu Ile Thr Ile Val Gly 
        35                  40                  45              
Asn Lys Tyr Val Gln Gly Phe Leu Asp Asn Thr Val Gly Ala Met Phe 
    50                  55                  60                  
Ser Gly Thr Trp Thr Pro Gly Asp Gly Leu Thr Gly Phe Gly Gly Gln 
65                  70                  75                  80  
Phe Ser Thr Ile Trp Lys Lys Asn Tyr Thr Asp Asn Val Thr Asp Glu 
                85                  90                  95      
Ser Thr Gly Ala Gln Lys Phe Gly Tyr Gly Ala Leu Gly Val Val Asn 
            100                 105                 110         
Ser Ile Leu Asn Val Ala Gly Asn Leu Ala Ala Ile Tyr Asn Leu Gly 
        115                 120                 125             
Phe Gly Thr Ala Lys Asn Ile Val Gly Glu Gly Val Tyr Lys Ala 
    130                 135                 140             

<210> 5
<211> 136
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 5
Met Met Met Pro Ala Asn Phe Ser Ala Val Ala Glu Asn Glu Met Thr 
1               5                   10                  15      
Tyr Val Val Gly Gly Ser Leu Val Asp Val Leu Ala Pro Ala Met Thr 
            20                  25                  30          
Thr Ala Asn Trp Gln Asn Val Ser Ala Asn Val Ile Lys Ile Val Gly 
        35                  40                  45              
Asn Ser Phe Leu Ala Lys Tyr Thr Asn Asp Val Leu Ala Gln Leu Phe 
    50                  55                  60                  
Asp Gly Asn Tyr Val Pro Gly Asp Val Ile Gly Tyr Ser Val Lys Asn 
65                  70                  75                  80  
Leu Asp Lys Ala Tyr Asn Lys Gly Tyr Gly Thr Phe Gly Gly Asn Trp 
                85                  90                  95      
Gly Phe Ala Val Gly Ala Leu Asn Ala Gly Met Gln Ile Leu Gly Gly 
            100                 105                 110         
Leu Ser Ala Ile Tyr Thr Leu Gly Ser Ser Ser Ile Gly Leu Glu Thr 
        115                 120                 125             
Lys Ser Gly Thr Leu Pro Thr Leu 
    130                 135     

<210> 6
<211> 142
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 6
Met Met Met Pro Ala Asn Phe Thr Ala Val Asn Ser Glu Val Val Tyr 
1               5                   10                  15      
Gly Gly Ala Asp Leu Phe Thr Ile Leu Ala Asp Thr Thr Ala Pro Ile 
            20                  25                  30          
Trp Asn Ala Ala Asn Val Lys Lys Phe Asn Thr Asn Leu Ile Thr Leu 
        35                  40                  45              
Ile Ser Asn Ser Phe Phe Lys Lys Thr Val Ser Asn Thr Leu Gly Val 
    50                  55                  60                  
Met Phe Gly Gly Asn Trp Gly Lys Asp Gly Asp Lys Ile Phe Gly Glu 
65                  70                  75                  80  
Glu Gly Ser Ile Asn Gln Asn Val Phe Gly Leu Trp Asn Asp Asp His 
                85                  90                  95      
Thr Thr Arg Thr Asp Asp Met Thr Phe Gly Asn Lys Val Met Gln Val 
            100                 105                 110         
Leu Gly Met Ala Ala Val Gly Tyr Thr Leu Gly Thr Thr Asp Ala Lys 
        115                 120                 125             
Val Gly Phe Asn Asp Gly Val Tyr Gly Ile Asn Gly Lys Leu 
    130                 135                 140         

<210> 7
<211> 147
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 7
Met Met Met Pro Ala Asn Phe Ser Ala Val Asn Ala Glu Val Val Tyr 
1               5                   10                  15      
Gly Gly Ala Val Ala Asp Tyr Leu Pro Ser Ala Trp Thr Ala Glu Ser 
            20                  25                  30          
Val Lys Arg Phe Asn Ser Asn Ile Ile Thr Leu Val Ser Asn Ser Phe 
        35                  40                  45              
Thr Ser His Leu Leu Lys Ala Thr Leu Gly Thr Met Phe Ser Gly Ser 
    50                  55                  60                  
Trp Gly Ser Asp Gly Val Thr Leu Phe Gly Asp Asn Gly Thr Phe Ser 
65                  70                  75                  80  
Gly Leu Tyr Asn Val Asn Arg Leu Pro Gly Gly Glu Ala Gln Thr Phe 
                85                  90                  95      
Gly Asn Lys Ile Met Thr Thr Leu Gly Leu Ala Ser Val Val Tyr Thr 
            100                 105                 110         
Leu Gly Met Lys Asp Ala Ala Val Leu Thr Ala Lys Lys Val Thr Asn 
        115                 120                 125             
Ser Asn Gly Gln Val Trp Gly Asp Leu Pro Asn Asn Gly Gly Ser Gly 
    130                 135                 140                 
Trp Val Gly 
145         

<210> 8
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> p49-70 portion of SEQ ID NO:2

<400> 8
Val Thr Leu Val Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr 
1               5                   10                  15      
Ile Gly Val Leu 
            20  

<210> 9
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> p35-77 portion of SEQ ID NO:2

<400> 9
Ile Trp Thr Leu Asp Asn Val Lys Thr Phe Asn Thr Asn Ile Val Thr 
1               5                   10                  15      
Leu Val Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr Ile Gly 
            20                  25                  30          
Val Leu Phe Ser Gly Asn Thr Thr Trp Lys Glu 
        35                  40              

<210> 10
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> SL3/3 fragment

<400> 10
Ile Thr Ile Val Gly Asn Lys Tyr Val Gln Gly Phe Leu Asp Asn Thr 
1               5                   10                  15      
Val Gly Ala Val 
            20  

<210> 11
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> M21/2 fragment

<400> 11
Ile Thr Ile Val Gly Asn Lys Tyr Val Gln Gly Phe Leu Asp Asn Thr 
1               5                   10                  15      
Val Gly Ala Met 
            20  

<210> 12
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> KLE1255 fragment

<400> 12
Ile Lys Ile Val Gly Asn Ser Phe Leu Ala Lys Tyr Thr Asn Asp Val 
1               5                   10                  15      
Leu Ala Gln Leu 
            20  

<210> 13
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> L2-61 fragment

<400> 13
Ile Thr Leu Ile Ser Asn Ser Phe Phe Lys Lys Thr Val Ser Asn Thr 
1               5                   10                  15      
Leu Gly Val Met 
            20  

<210> 14
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> L2-62 fragment

<400> 14
Ile Thr Leu Val Ser Asn Ser Phe Thr Ser His Leu Leu Lys Ala Thr 
1               5                   10                  15      
Leu Gly Thr Met 
            20  

<210> 15
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAG821 fragment

<400> 15
Val Thr Ile Ile Gly Asn Ser Tyr Val Ser Lys Leu Val Gly Ala Thr 
1               5                   10                  15      
Leu Gly Val Met 
            20  

<210> 16
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAG822 fragment

<400> 16
Ile Thr Ile Ile Gly Asn Ser Tyr Val Ser Lys Val Leu Gly Ala Thr 
1               5                   10                  15      
Leu Gly Val Met 
            20  

<210> 17
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> CNCM-4573 fragment

<400> 17
Ile Val Gly Asn Lys Tyr Val Gln Gly Phe Leu Asp Asn Thr Val Gly 
1               5                   10                  15      
Ala Val 
        

<210> 18
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> SL3/3 fragment

<400> 18
Ala Met Gly Ala Ala Gln Trp Gln Asn Phe His Lys Asn Leu Ile Thr 
1               5                   10                  15      
Ile Val Gly Asn Lys Tyr Val Gln Gly Phe Leu Asp Asn Thr Val Gly 
            20                  25                  30          
Ala Val Phe Ser Gly Thr Trp Thr Pro Gly Asp 
        35                  40              

<210> 19
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> M21/2 fragment

<400> 19
Ala Met Gly Ala Ala Gln Trp Gln Asn Phe His Lys Asn Leu Ile Thr 
1               5                   10                  15      
Ile Val Gly Asn Lys Tyr Val Gln Gly Phe Leu Asp Asn Thr Val Gly 
            20                  25                  30          
Ala Met Phe Ser Gly Thr Trp Thr Pro Gly Asp 
        35                  40              

<210> 20
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> KLE1255 fragment

<400> 20
Ala Met Thr Thr Ala Asn Trp Gln Asn Val Ser Ala Asn Val Ile Lys 
1               5                   10                  15      
Ile Val Gly Asn Ser Phe Leu Ala Lys Tyr Thr Asn Asp Val Leu Ala 
            20                  25                  30          
Gln Leu Phe Asp Gly Asn Tyr Val Pro Gly Asp 
        35                  40              

<210> 21
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> L2-61 fragment

<400> 21
Ile Trp Asn Ala Ala Asn Val Lys Lys Phe Asn Thr Asn Leu Ile Thr 
1               5                   10                  15      
Leu Ile Ser Asn Ser Phe Phe Lys Lys Thr Val Ser Asn Thr Leu Gly 
            20                  25                  30          
Val Met Phe Gly Gly Asn Trp Gly Lys Asp Gly 
        35                  40              

<210> 22
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> L2-62 fragment

<400> 22
Ala Trp Thr Ala Glu Ser Val Lys Arg Phe Asn Ser Asn Ile Ile Thr 
1               5                   10                  15      
Leu Val Ser Asn Ser Phe Thr Ser His Leu Leu Lys Ala Thr Leu Gly 
            20                  25                  30          
Thr Met Phe Ser Gly Ser Trp Gly Ser Asp Gly 
        35                  40              

<210> 23
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAG:821 fragment

<400> 23
Ile Trp Thr Thr Ala Asn Val Lys Thr Phe Asn Thr Asn Leu Val Thr 
1               5                   10                  15      
Ile Ile Gly Asn Ser Tyr Val Ser Lys Leu Val Gly Ala Thr Leu Gly 
            20                  25                  30          
Val Met Phe Gly Gly Asn Trp Gly Gly Asp Gly 
        35                  40              

<210> 24
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> CAG:822 fragment

<400> 24
Val Trp Gly Ala Ala Asn Val Lys Thr Phe Asn Thr Asn Leu Ile Thr 
1               5                   10                  15      
Ile Ile Gly Asn Ser Tyr Val Ser Lys Val Leu Gly Ala Thr Leu Gly 
            20                  25                  30          
Val Met Phe Ser Gly Ala Trp Gly Thr Lys Asp 
        35                  40              

<210> 25
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> CNCM-4573 fragment

<400> 25
Ala Met Gly Ala Ala Gln Trp Gln Asn Phe His Lys Asn Leu Val Thr 
1               5                   10                  15      
Ile Val Gly Asn Lys Tyr Val Gln Gly Phe Leu Asp Asn Thr Val Gly 
            20                  25                  30          
Ala Val Phe Ser Gly Thr Trp Thr Pro Gly Val 
        35                  40              

<210> 26
<211> 43
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 26
Phe Ser Gly Asn Thr Thr Trp Lys Glu Val Gly Asn Ile Gly Lys Asn 
1               5                   10                  15      
Leu Phe Gly Thr Asn Val Lys Gly Asn Pro Ile Glu Lys Asn Asn Phe 
            20                  25                  30          
Gly Asp Tyr Ala Met Asn Ala Leu Gly Ile Ala 
        35                  40              

<210> 27
<211> 16
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 27
Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr Ile Gly Val Leu 
1               5                   10                  15      



<210> 28
<211> 17
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 28
Val Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr Ile Gly Val 
1               5                   10                  15      
Leu 
    

<210> 29
<211> 18
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 29
Leu Val Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr Ile Gly 
1               5                   10                  15      
Val Leu 
        

<210> 30
<211> 19
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 30
Thr Leu Val Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr Ile 
1               5                   10                  15      
Gly Val Leu 
            

<210> 31
<211> 20
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 31
Val Thr Leu Val Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr 
1               5                   10                  15      
Ile Gly Val Leu 
            20  

<210> 32
<211> 42
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fragment

<400> 32
Ile Trp Thr Leu Asp Asn Val Lys Thr Phe Asn Thr Asn Ile Val Thr 
1               5                   10                  15      
Leu Val Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr Ile Gly 
            20                  25                  30          
Val Leu Phe Ser Gly Asn Thr Thr Trp Lys 
        35                  40          

<210> 33
<211> 99
<212> PRT
<213> Artificial Sequence


<220> 
<223> MUT3

<400> 33
Met Met Met Pro Ala Asn Tyr Ser Val Ile Ala Glu Asn Glu Met Thr 
1               5                   10                  15      
Tyr Val Asn Gly Gly Ala Asn Phe Ile Asp Ala Ile Gly Ala Val Thr 
            20                  25                  30          
Ala Pro Ile Trp Thr Leu Asp Asn Val Lys Thr Phe Asn Thr Asn Ile 
        35                  40                  45              
Val Thr Leu Val Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr 
    50                  55                  60                  
Ile Gly Val Leu Phe Ser Gly Asn Thr Thr Trp Lys Glu Val Gly Asn 
65                  70                  75                  80  
Ile Gly Lys Asn Leu Phe Gly Thr Asn Val Lys Gly Asn Pro Ile Glu 
                85                  90                  95      
Lys Asn Asn 
            

<210> 34
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> MUT1

<400> 34
Asn Phe Ile Asp Ala Ile Gly Ala Val Thr Ala Pro Ile Trp Thr Leu 
1               5                   10                  15      
Asp Asn Val Lys Thr Phe Asn Thr Asn Ile Val Thr Leu Val Gly Asn 
            20                  25                  30          
Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr Ile Gly Val Leu Phe Ser 
        35                  40                  45              
Gly Asn Thr Thr Trp Lys Glu Val Gly Asn Ile Gly Lys Asn Leu Phe 
    50                  55                  60                  
Gly Thr Asn Val Lys Gly Asn Pro Ile Glu Lys Asn Asn Phe Gly Asp 
65                  70                  75                  80  
Tyr Ala Met Asn Ala Leu Gly Ile Ala Ala Ala Val Tyr Asn Leu Gly 
                85                  90                  95      
Val Ala Pro Thr Lys Asn Thr Val Lys Glu Thr Glu Val Lys Phe Thr 
            100                 105                 110         
Val 
    

<210> 35
<211> 15
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 35
Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr Ile Gly Val Leu 
1               5                   10                  15  

<210> 36
<211> 24
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 36
Ala Ala Val Tyr Asn Leu Gly Val Ala Pro Thr Lys Asn Thr Val Lys 
1               5                   10                  15      
Glu Thr Glu Val Lys Phe Thr Val 
            20                  

<210> 37
<211> 47
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 37
Asn Tyr Ser Val Ile Ala Glu Asn Glu Met Thr Tyr Val Asn Gly Gly 
1               5                   10                  15      
Ala Asn Phe Ile Asp Ala Ile Gly Ala Val Thr Ala Pro Ile Trp Thr 
            20                  25                  30          
Leu Asp Asn Val Lys Thr Phe Asn Thr Asn Ile Val Thr Leu Val 
        35                  40                  45          

<210> 38
<211> 17
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 38
Lys Gly Asn Thr Phe Leu Gln Ser Thr Ile Asn Arg Thr Ile Gly Val 
1               5                   10                  15      
Leu 
    

<210> 39
<211> 46
<212> PRT
<213> Faecalibacterium prausnitzii


<400> 39
Val Lys Gly Asn Pro Ile Glu Lys Asn Asn Phe Gly Asp Tyr Ala Met 
1               5                   10                  15      
Asn Ala Leu Gly Ile Ala Ala Ala Val Tyr Asn Leu Gly Val Ala Pro 
            20                  25                  30          
Thr Lys Asn Thr Val Lys Glu Thr Glu Val Lys Phe Thr Val 
        35                  40                  45      

