                         SEQUENCE LISTING

<110>  Centre national de la recherche scientifique
       INSERM
 
<120>  ANTISENSE RNA TARGETING PMP22 FOR THE TREATMENT OF 
       CHARCOT-MARIE-TOOTH 1A DISEASE

<130>  BET19P3966

<150>  EP18306241.3
<151>  2018-09-25

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting PMP22

<400>  1
ggcucuguuc cuguucuuc                                                    19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting PMP22

<400>  2
accuauuuau aacacuuuu                                                    19


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting PMP22

<400>  3
acaauaaaua aaucucaaa                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting PMP22

<400>  4
ccucguguug aaucuuaaa                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting PMP22

<400>  5
ccaccaacug uagauguau                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting PMP22

<400>  6
cuguccaggc caccaugau                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting PMP22

<400>  7
auaccaacug uguggacua                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting PMP22

<400>  8
aaaccuauuu auaacacuu                                                    19


<210>  9
<211>  1861
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (239)..(721)

<400>  9
aataaactgg aaagacgcct ggtctggctt cagttacagg gagcaccacc agggaacatc       60

tcggggagcc tggttggaag ctgcaggctt agtctgtcgg ctgcgggtct ctgactgccc      120

tgtggggagg gtcttgcctt aacatccctt gcatttggct gcaaagaaat ctgcttggaa      180

gaaggggtta cgctgtttgg ccgggcagaa actccgctga gcagaacttg ccgccaga        238

atg ctc ctc ctg ttg ctg agt atc atc gtc ctc cac gtc gcg gtg ctg        286
Met Leu Leu Leu Leu Leu Ser Ile Ile Val Leu His Val Ala Val Leu           
1               5                   10                  15                

gtg ctg ctg ttc gtc tcc acg atc gtc agc caa tgg atc gtg ggc aat        334
Val Leu Leu Phe Val Ser Thr Ile Val Ser Gln Trp Ile Val Gly Asn           
            20                  25                  30                    

gga cac gca act gat ctc tgg cag aac tgt agc acc tct tcc tca gga        382
Gly His Ala Thr Asp Leu Trp Gln Asn Cys Ser Thr Ser Ser Ser Gly           
        35                  40                  45                        

aat gtc cac cac tgt ttc tca tca tca cca aac gaa tgg ctg cag tct        430
Asn Val His His Cys Phe Ser Ser Ser Pro Asn Glu Trp Leu Gln Ser           
    50                  55                  60                            

gtc cag gcc acc atg atc ctg tcg atc atc ttc agc att ctg tct ctg        478
Val Gln Ala Thr Met Ile Leu Ser Ile Ile Phe Ser Ile Leu Ser Leu           
65                  70                  75                  80            

ttc ctg ttc ttc tgc caa ctc ttc acc ctc acc aag ggg ggc agg ttt        526
Phe Leu Phe Phe Cys Gln Leu Phe Thr Leu Thr Lys Gly Gly Arg Phe           
                85                  90                  95                

tac atc act gga atc ttc caa att ctt gct ggt ctg tgc gtg atg agt        574
Tyr Ile Thr Gly Ile Phe Gln Ile Leu Ala Gly Leu Cys Val Met Ser           
            100                 105                 110                   

gct gcg gcc atc tac acg gtg agg cac ccg gag tgg cat ctc aac tcg        622
Ala Ala Ala Ile Tyr Thr Val Arg His Pro Glu Trp His Leu Asn Ser           
        115                 120                 125                       

gat tac tcc tac ggt ttc gcc tac atc ctg gcc tgg gtg gcc ttc ccc        670
Asp Tyr Ser Tyr Gly Phe Ala Tyr Ile Leu Ala Trp Val Ala Phe Pro           
    130                 135                 140                           

ctg gcc ctt ctc agc ggt gtc atc tat gtg atc ttg cgg aaa cgc gaa        718
Leu Ala Leu Leu Ser Gly Val Ile Tyr Val Ile Leu Arg Lys Arg Glu           
145                 150                 155                 160           

tga ggcgcccaga cggtctgtct gaggctctga gcgtacatag ggaagggagg             771

aagggaaaac agaaagcaga caaagaaaaa agagctagcc caaaatccca aactcaaacc      831

aaaccaaaca gaaagcagtg gaggtggggg ttgctgttga ttgaagatgt atataatatc      891

tccggtttat aaaacctatt tataacactt tttacatata tgtacatagt attgtttgct      951

ttttatgttg accatcagcc tcgtgttgag ccttaaagaa gtagctaagg aactttacat     1011

cctaacagta taatccagct cagtattttt gttttgtttt ttgtttgttt gttttgtttt     1071

acccagaaat aagataactc catctcgccc cttccctttc atctgaaaga agatacctcc     1131

ctcccagtcc acctcattta gaaaaccaaa gtgtgggtag aaaccccaaa tgtccaaaag     1191

cccttttctg gtgggtgacc cagtgcatcc aacagaaaca gccgctgccc gaacctctgt     1251

gtgaagcttt acgcgcacac ggacaaaatg cccaaactgg agcccttgca aaaacacggc     1311

ttgtggcatt ggcatacttg cccttacagg tggagtatct tcgtcacaca tctaaatgag     1371

aaatcagtga caacaagtct ttgaaatggt gctatggatt taccattcct tattatcact     1431

aatcatctaa acaactcact ggaaatccaa ttaacaattt tacaacataa gatagaatgg     1491

agacctgaat aattctgtgt aatataaatg gtttataact gcttttgtac ctagctaggc     1551

tgctattatt actataatga gtaaatcata aagccttcat cactcccaca tttttcttac     1611

ggtcggagca tcagaacaag cgtctagact ccttgggacc gtgagttcct agagcttggc     1671

tgggtctagg ctgttctgtg cctccaagga ctgtctggca atgacttgta ttggccacca     1731

actgtagatg tatatatggt gcccttctga tgctaagact ccagaccttt tgtttttgct     1791

ttgcattttc tgattttata ccaactgtgt ggactaagat gcattaaaat aaacatcaga     1851

gtaactcact                                                            1861


<210>  10
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Leu Leu Leu Leu Ser Ile Ile Val Leu His Val Ala Val Leu 
1               5                   10                  15      


Val Leu Leu Phe Val Ser Thr Ile Val Ser Gln Trp Ile Val Gly Asn 
            20                  25                  30          


Gly His Ala Thr Asp Leu Trp Gln Asn Cys Ser Thr Ser Ser Ser Gly 
        35                  40                  45              


Asn Val His His Cys Phe Ser Ser Ser Pro Asn Glu Trp Leu Gln Ser 
    50                  55                  60                  


Val Gln Ala Thr Met Ile Leu Ser Ile Ile Phe Ser Ile Leu Ser Leu 
65                  70                  75                  80  


Phe Leu Phe Phe Cys Gln Leu Phe Thr Leu Thr Lys Gly Gly Arg Phe 
                85                  90                  95      


Tyr Ile Thr Gly Ile Phe Gln Ile Leu Ala Gly Leu Cys Val Met Ser 
            100                 105                 110         


Ala Ala Ala Ile Tyr Thr Val Arg His Pro Glu Trp His Leu Asn Ser 
        115                 120                 125             


Asp Tyr Ser Tyr Gly Phe Ala Tyr Ile Leu Ala Trp Val Ala Phe Pro 
    130                 135                 140                 


Leu Ala Leu Leu Ser Gly Val Ile Tyr Val Ile Leu Arg Lys Arg Glu 
145                 150                 155                 160 


<210>  11
<211>  1865
<212>  DNA
<213>  Mus musculus

<400>  11
acacccttct gcagcgacgc aaatagggcg tagttcccgt taaaggggaa caccgggagc       60

ctcccactgc ccccttgctt tgcgcgcgcg ctgacccgca gcacagctgt ctttggggac      120

gccagcaacc cagtggacgc accggagttt gtgcctgagg ctaatctgct ctgagatagc      180

tgtccctttg aactgaaaca ggcaccgctc ctctgatccc gagcccaact cccagccacc      240

atgctcctac tcttgttggg gatcctgttc ctgcacatcg cggtgctagt gttgctcttc      300

gtctccacca tcgtcagcca atggctcgtg ggcaatggac acacgactga tctctggcag      360

aactgtacca catccgcctt gggagccgtc caacactgct actcctcatc agtgagcgaa      420

tggctgcagt ctgtccaggc caccatgatc ctgtctgtca tcttcagcgt cctggctctg      480

ttcctgttct tctgccagct cttcactctc accaaaggcg gccggtttta catcactgga      540

ttcttccaaa tccttgctgg tctgtgcgtg atgagtgcag cggccatcta cacagtgagg      600

cacagtgagt ggcatgtcaa cactgactac tcctatggct tcgcctacat cctggcctgg      660

gtggcctttc ccctagccct cctcagtggt atcatctatg tgatcctgcg gaaacgcgaa      720

tgaggcgccc gacgacgcac cgtccgtcta ggctctgagc gcgcataggg tccacaggga      780

gggaggaagg aaaccagaga acaaaaccaa ccaaccaaaa aagagctagc cccaaaccca      840

aacgcaagcc aaaccaaaca gaacgcagtt gagtggggat tgctgttgat tgaagatgta      900

tataatatct atggtttata aaacctattt ataacacttt ttacatatat gtacatagga      960

ttgttttgct ttttatgttg accgtcagcc tcgtgttgaa tcttaaacaa ctttacatcc     1020

taacactata accaagctca gtatctttgt tttgtttcgt tttttttttt aatctttttg     1080

ttttgctcag acataaaaac tccacgtggc cccctttcat ctgaaagcag atacctccct     1140

cccactcaac ctcataggat aaccaaagtg tggggacaaa ccccagacag ttgaagacct     1200

ttacactatg ggtgacccag tgcatttagc aggagtatcc actgcccgaa tccatgtgtg     1260

aagccctaag cactcacaga cgaaaagccc tgaccggaac cctctgcaaa aacagtaata     1320

gctggtggct cctgaacact tgaccctgta gacggagtac tggggccaca cgtttaaatg     1380

agaagtcaga gacaagcaat ctgtgaaatg gtgctataga tttaccattc cttgttatta     1440

ctaatcgttt aaaccactca ctggaaactc aattaacagt tttatgcgat acagcagaat     1500

ggagacccga tacaaacggt tcataactgc tttcatacct agctaggctg ttgttattac     1560

tacaataaat aaatctcaaa gccttcgtca gtcccacagt tttctcacgg tcggagcatc     1620

aggacgagca tctagaccct tgggactagc gagttccctg gctttctggg tctagagtgt     1680

tctgtgcctc caaggactgt ctggcgatga cttgtattgg ccaccaactg tagatgtata     1740

tacggtgtcc ttctgatgct aagactccag acctttcttg tttttgcttg ctttctctga     1800

ttttatacca actgtgtgga ctaagatgca tcaaaataaa catcagagta actcaaaaaa     1860

aaaaa                                                                 1865


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  as siRNA targeting PMP22

<400>  12
gaagaacagg aacagagcc                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  as siRNA targeting PMP22

<400>  13
aaaaguguua uaaauaggu                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  as siRNA targeting PMP22

<400>  14
uuugagauuu auuuauugu                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  as siRNA targeting PMP22

<400>  15
uuuaagauuc aacacgagg                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  as siRNA targeting PMP22

<400>  16
auacaucuac aguuggugg                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  as siRNA targeting PMP22

<400>  17
aucauggugg ccuggacag                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  as siRNA targeting PMP22

<400>  18
uaguccacac aguugguau                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  as siRNA targeting PMP22

<400>  19
aaguguuaua aauagguuu                                                    19


