                         SEQUENCE LISTING

<110>  Lentigen Technology, Inc.
 
<120>  Compositions and Methods for Treating Cancer with DuoCARs

<130>  42449-0029WO1

<150>  16/078,269
<151>  2018-08-21

<150>  16/134,735
<151>  2018-09-18

<150>  PCT/US2017/049923
<151>  2017-09-01

<150>  US 62/382,791
<151>  2016-09-02

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  729
<212>  DNA
<213>  Artificial

<220>
<223>  CD20-reactive scFv binding domain (LTG1495)

<400>  1
gaggtgcagt tgcaacagtc aggagctgaa ctggtcaagc caggagccag cgtgaagatg       60

agctgcaagg cctccggtta caccttcacc tcctacaaca tgcactgggt gaaacagacc      120

ccgggacaag ggctcgaatg gattggcgcc atctaccccg ggaatggcga tacttcgtac      180

aaccagaagt tcaagggaaa ggccaccctg accgccgaca agagctcctc caccgcgtat      240

atgcagttga gctccctgac ctccgaggac tccgccgact actactgcgc acggtccaac      300

tactatggaa gctcgtactg gttcttcgat gtctgggggg ccggcaccac tgtgaccgtc      360

agctccgggg gcggaggatc cggtggaggc ggaagcgggg gtggaggatc cgacattgtg      420

ctgactcagt ccccggcaat cctgtcggcc tcaccgggcg aaaaggtcac gatgacttgt      480

agagcgtcgt ccagcgtgaa ctacatggat tggtaccaaa agaagcctgg atcgtcaccc      540

aagccttgga tctacgctac atctaacctg gcctccggcg tgccagcgcg gttcagcggg      600

tccggctcgg gcacctcata ctcgctgacc atctcccgcg tggaggctga ggacgccgcg      660

acctactact gccagcagtg gtccttcaac ccgccgactt ttggaggcgg tactaagctg      720

gagatcaaa                                                              729


<210>  2
<211>  243
<212>  PRT
<213>  Artificial

<220>
<223>  CD20-reactive scFv binding domain (LTG1495)

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Asn Tyr Met Asp Trp Tyr Gln Lys Lys Pro 
                165                 170                 175     


Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  3
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG1495 (LP-1495-CD8 TM-41BB-CD3zeta)

<400>  3
atgctccttc tcgtgacctc cctgcttctc tgcgaactgc cccatcctgc cttcctgctg       60

attcccgagg tgcagttgca acagtcagga gctgaactgg tcaagccagg agccagcgtg      120

aagatgagct gcaaggcctc cggttacacc ttcacctcct acaacatgca ctgggtgaaa      180

cagaccccgg gacaagggct cgaatggatt ggcgccatct accccgggaa tggcgatact      240

tcgtacaacc agaagttcaa gggaaaggcc accctgaccg ccgacaagag ctcctccacc      300

gcgtatatgc agttgagctc cctgacctcc gaggactccg ccgactacta ctgcgcacgg      360

tccaactact atggaagctc gtactggttc ttcgatgtct ggggggccgg caccactgtg      420

accgtcagct ccgggggcgg aggatccggt ggaggcggaa gcgggggtgg aggatccgac      480

attgtgctga ctcagtcccc ggcaatcctg tcggcctcac cgggcgaaaa ggtcacgatg      540

acttgtagag cgtcgtccag cgtgaactac atggattggt accaaaagaa gcctggatcg      600

tcacccaagc cttggatcta cgctacatct aacctggcct ccggcgtgcc agcgcggttc      660

agcgggtccg gctcgggcac ctcatactcg ctgaccatct cccgcgtgga ggctgaggac      720

gccgcgacct actactgcca gcagtggtcc ttcaacccgc cgacttttgg aggcggtact      780

aagctggaga tcaaagcggc cgcaactacc acccctgccc ctcggccgcc gactccggcc      840

ccaaccatcg caagccaacc cctctccttg cgccccgaag cttgccgccc ggccgcgggt      900

ggagccgtgc atacccgggg gctggacttt gcctgcgata tctacatttg ggccccgctg      960

gccggcactt gcggcgtgct cctgctgtcg ctggtcatca ccctttactg caagaggggc     1020

cggaagaagc tgctttacat cttcaagcag ccgttcatgc ggcccgtgca gacgactcag     1080

gaagaggacg gatgctcgtg cagattccct gaggaggaag aggggggatg cgaactgcgc     1140

gtcaagttct cacggtccgc cgacgccccc gcatatcaac agggccagaa tcagctctac     1200

aacgagctga acctgggaag gagagaggag tacgacgtgc tggacaagcg acgcggacgc     1260

gacccggaga tgggggggaa accacggcgg aaaaaccctc aggaaggact gtacaacgaa     1320

ctccagaaag acaagatggc ggaagcctac tcagaaatcg ggatgaaggg agagcggagg     1380

aggggaaagg gtcacgacgg gctgtaccag ggactgagca ccgccactaa ggatacctac     1440

gatgccttgc atatgcaagc actcccaccc cgg                                  1473


<210>  4
<211>  491
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG1495 (LP-1495-CD8 TM-41BB-CD3zeta)

<400>  4

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
        115                 120                 125             


Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
                165                 170                 175     


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
            180                 185                 190         


Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
        195                 200                 205             


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
225                 230                 235                 240 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  5
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  5
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccg                                                                  66


<210>  6
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  6

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  7
<211>  747
<212>  DNA
<213>  Artificial

<220>
<223>  CD22-reactive scFv binding domain LTG2200)

<400>  7
caggtacagc tccagcagag tggcccaggg ctcgtgaagc caagccagac gctgtccctg       60

acttgtgcaa tttcagggga ttcagtttca tcaaatagcg cggcgtggaa ttggattcga      120

caatctcctt cccgagggtt ggaatggctt ggacgaacat attacagatc caaatggtat      180

aacgactatg cggtatcagt aaagtcaaga ataaccatta accccgacac aagcaagaac      240

caattctctt tgcagcttaa ctctgtcacg ccagaagaca cggcagtcta ttattgcgct      300

cgcgaggtaa cgggtgacct ggaagacgct tttgacattt gggggcaggg tacgatggtg      360

acagtcagtt cagggggcgg tgggagtggg ggagggggta gcgggggggg agggtcagac      420

attcagatga cccagtcccc ttcatccttg tctgcctccg tcggtgacag ggtgacaata      480

acatgcagag caagccaaac aatctggagc tatctcaact ggtaccagca gcgaccagga      540

aaagcgccaa acctgctgat ttacgctgct tcctccctcc aatcaggcgt gcctagtaga      600

tttagcggta ggggctccgg caccgatttt acgctcacta taagctctct tcaagcagaa      660

gattttgcga cttattactg ccagcagtcc tatagtatac ctcagacttt cggacagggt      720

accaagttgg agattaaggc ggccgca                                          747


<210>  8
<211>  249
<212>  PRT
<213>  Artificial

<220>
<223>  CD22-reactive scFv binding domain (LTG2200)

<400>  8

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Ala Ala Ala 
                245                 


<210>  9
<211>  1482
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG2200 (LP-2200-CD8 TM-41BB-CD3zeta)

<400>  9
atgcttcttt tggtgacttc ccttttgctg tgcgagttgc cacaccccgc cttcctgctt       60

attccccagg tacagctcca gcagagtggc ccagggctcg tgaagccaag ccagacgctg      120

tccctgactt gtgcaatttc aggggattca gtttcatcaa atagcgcggc gtggaattgg      180

attcgacaat ctccttcccg agggttggaa tggcttggac gaacatatta cagatccaaa      240

tggtataacg actatgcggt atcagtaaag tcaagaataa ccattaaccc cgacacaagc      300

aagaaccaat tctctttgca gcttaactct gtcacgccag aagacacggc agtctattat      360

tgcgctcgcg aggtaacggg tgacctggaa gacgcttttg acatttgggg gcagggtacg      420

atggtgacag tcagttcagg gggcggtggg agtgggggag ggggtagcgg ggggggaggg      480

tcagacattc agatgaccca gtccccttca tccttgtctg cctccgtcgg tgacagggtg      540

acaataacat gcagagcaag ccaaacaatc tggagctatc tcaactggta ccagcagcga      600

ccaggaaaag cgccaaacct gctgatttac gctgcttcct ccctccaatc aggcgtgcct      660

agtagattta gcggtagggg ctccggcacc gattttacgc tcactataag ctctcttcaa      720

gcagaagatt ttgcgactta ttactgccag cagtcctata gtatacctca gactttcgga      780

cagggtacca agttggagat taaggcggcc gcaactacca cccctgcccc tcggccgccg      840

actccggccc caaccatcgc aagccaaccc ctctccttgc gccccgaagc ttgccgcccg      900

gccgcgggtg gagccgtgca tacccggggg ctggactttg cctgcgatat ctacatttgg      960

gccccgctgg ccggcacttg cggcgtgctc ctgctgtcgc tggtcatcac cctttactgc     1020

aagaggggcc ggaagaagct gctttacatc ttcaagcagc cgttcatgcg gcccgtgcag     1080

acgactcagg aagaggacgg atgctcgtgc agattccctg aggaggaaga ggggggatgc     1140

gaactgcgcg tcaagttctc acggtccgcc gacgcccccg catatcaaca gggccagaat     1200

cagctctaca acgagctgaa cctgggaagg agagaggagt acgacgtgct ggacaagcga     1260

cgcggacgcg acccggagat gggggggaaa ccacggcgga aaaaccctca ggaaggactg     1320

tacaacgaac tccagaaaga caagatggcg gaagcctact cagaaatcgg gatgaaggga     1380

gagcggagga ggggaaaggg tcacgacggg ctgtaccagg gactgagcac cgccactaag     1440

gatacctacg atgccttgca tatgcaagca ctcccacccc gg                        1482


<210>  10
<211>  494
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG2200(LP-2200-CD8 TM-41BB-CD3zeta)

<400>  10

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp 
        115                 120                 125             


Leu Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                165                 170                 175     


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser 
            180                 185                 190         


Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu 
        195                 200                 205             


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    210                 215                 220                 


Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro 
                245                 250                 255     


Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  11
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  CD8 transmembrane domain

<400>  11
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  12
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  CD8 transmembrane domain

<400>  12

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210>  13
<211>  141
<212>  DNA
<213>  Artificial

<220>
<223>  CD8 hinge domain

<400>  13
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gactttgcct gcgatatcta c                                                141


<210>  14
<211>  47
<212>  PRT
<213>  Artificial

<220>
<223>  CD8 hinge domain

<400>  14

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  15
<211>  69
<212>  PRT
<213>  Artificial

<220>
<223>  hinge and transmembrane region of CD8.alpha

<400>  15

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  16
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Human IgG CL

<400>  16

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  17
<211>  126
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  17
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  18
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  18

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  19
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  signaling domain of CD3-zeta

<400>  19
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  20
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  20

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  21
<211>  1467
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG1562 (LP-CD19binder-CD8linker-CD4tm-4-1BB-CD3-zeta)

<400>  21
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggata ttcagatgac ccagaccacc agcagcctga gcgcgagcct gggcgatcgc      120

gtgaccatta gctgccgcgc gagccaggat attagcaaat atctgaactg gtatcagcag      180

aaaccggatg gcaccgtgaa actgctgatt tatcatacca gccgcctgca tagcggcgtg      240

ccgagccgct ttagcggcag cggcagcggc accgattata gcctgaccat tagcaacctg      300

gaacaggaag atattgcgac ctatttttgc cagcagggca acaccctgcc gtataccttt      360

ggcggcggca ccaaactgga aattaccggc ggcggcggca gcggcggcgg cggcagcggc      420

ggcggcggca gcgaagtgaa actgcaggaa agcggcccgg gcctggtggc gccgagccag      480

agcctgagcg tgacctgcac cgtgagcggc gtgagcctgc cggattatgg cgtgagctgg      540

attcgccagc cgccgcgcaa aggcctggaa tggctgggcg tgatttgggg cagcgaaacc      600

acctattata acagcgcgct gaaaagccgc ctgaccatta ttaaagataa cagcaaaagc      660

caggtgtttc tgaaaatgaa cagcctgcag accgatgata ccgcgattta ttattgcgcg      720

aaacattatt attatggcgg cagctatgcg atggattatt ggggccaggg caccagcgtg      780

accgtgagca gcgcggcggc gccggcgccg cgcccgccga ccccggcgcc gaccattgcg      840

agccagccgc tgagcctgcg cccggaagcg tgccgcccgg cggcgggcgg cgcggtgcat      900

acccgcggcc tggattttgt gcagccgatg gcgctgattg tgctgggcgg cgtggcgggc      960

ctgctgctgt ttattggcct gggcattttt ttttgcgtgc gctgccgccc gcgccgcaaa     1020

aaactgctgt atatttttaa acagccgttt atgcgcccgg tgcagaccac ccaggaagaa     1080

gatggctgca gctgccgctt tccggaagaa gaagaaggcg gctgcgaact gcgcgtgaaa     1140

tttagccgca gcgcggatgc gccggcgtat cagcagggcc agaaccagct gtataacgaa     1200

ctgaacctgg gccgccgcga agaatatgat gtgctggata aacgccgcgg ccgcgatccg     1260

gaaatgggcg gcaaaccgcg ccgcaaaaac ccgcaggaag gcctgtataa cgaactgcag     1320

aaagataaaa tggcggaagc gtatagcgaa attggcatga aaggcgaacg ccgccgcggc     1380

aaaggccatg atggcctgta tcagggcctg agcaccgcga ccaaagatac ctatgatgcg     1440

ctgcatatgc aggcgctgcc gccgcgc                                         1467


<210>  22
<211>  489
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG1562 (LP-CD19binder-CD8link-CD4tm-41BB-CD3zeta)

<400>  22

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
                165                 170                 175     


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
            180                 185                 190         


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
        195                 200                 205             


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
    210                 215                 220                 


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly 
305                 310                 315                 320 


Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg 
                325                 330                 335     


Pro Arg Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  23
<211>  1548
<212>  DNA
<213>  Artificial

<220>
<223>  CD20_19-reactive scFv binding domain (LTG1497 dual specific 
       binder)

<400>  23
gaggtgcagt tgcaacagtc aggagctgaa ctggtcaagc caggagccag cgtgaagatg       60

agctgcaagg cctccggtta caccttcacc tcctacaaca tgcactgggt gaaacagacc      120

ccgggacaag ggctcgaatg gattggcgcc atctaccccg ggaatggcga tacttcgtac      180

aaccagaagt tcaagggaaa ggccaccctg accgccgaca agagctcctc caccgcgtat      240

atgcagttga gctccctgac ctccgaggac tccgccgact actactgcgc acggtccaac      300

tactatggaa gctcgtactg gttcttcgat gtctgggggg ccggcaccac tgtgaccgtc      360

agctccgggg gcggaggatc cggtggaggc ggaagcgggg gtggaggatc cgacattgtg      420

ctgactcagt ccccggcaat cctgtcggcc tcaccgggcg aaaaggtcac gatgacttgt      480

agagcgtcgt ccagcgtgaa ctacatggat tggtaccaaa agaagcctgg atcgtcaccc      540

aagccttgga tctacgctac atctaacctg gcctccggcg tgccagcgcg gttcagcggg      600

tccggctcgg gcacctcata ctcgctgacc atctcccgcg tggaggctga ggacgccgcg      660

acctactact gccagcagtg gtccttcaac ccgccgactt ttggaggcgg tactaagctg      720

gagatcaaag gaggcggcgg cagcggcggg ggagggtccg gagggggtgg ttctggtgga      780

ggaggatcgg gaggcggtgg cagcgacatt cagatgactc agaccacctc ctccctgtcc      840

gcctccctgg gcgaccgcgt gaccatctca tgccgcgcca gccaggacat ctcgaagtac      900

ctcaactggt accagcagaa gcccgacgga accgtgaagc tcctgatcta ccacacctcc      960

cggctgcaca gcggagtgcc gtctagattc tcgggttcgg ggtcgggaac tgactactcc     1020

cttactattt ccaacctgga gcaggaggat attgccacct acttctgcca acaaggaaac     1080

accctgccgt acacttttgg cgggggaacc aagctggaaa tcactggcag cacatccggt     1140

tccgggaagc ccggctccgg agagggcagc accaaggggg aagtcaagct gcaggaatca     1200

ggacctggcc tggtggcccc gagccagtca ctgtccgtga cttgtactgt gtccggagtg     1260

tcgctcccgg attacggagt gtcctggatc aggcagccac ctcggaaagg attggaatgg     1320

ctcggagtca tctggggttc cgaaaccacc tattacaact cggcactgaa atccaggctc     1380

accattatca aggataactc caagtcacaa gtgttcctga agatgaatag cctgcagact     1440

gacgacacgg cgatctacta ttgcgccaag cactactact acggcggatc ctacgctatg     1500

gactactggg gccaggggac cagcgtgacc gtgtcatccg cggccgca                  1548


<210>  24
<211>  516
<212>  PRT
<213>  Artificial

<220>
<223>  CD20_19-reactive scFv binding domain (LTG1497 dual specific 
       binder)

<400>  24

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Asn Tyr Met Asp Trp Tyr Gln Lys Lys Pro 
                165                 170                 175     


Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser 
305                 310                 315                 320 


Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly 
        355                 360                 365             


Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser 
385                 390                 395                 400 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                405                 410                 415     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            420                 425                 430         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        435                 440                 445             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    450                 455                 460                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
465                 470                 475                 480 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                485                 490                 495     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            500                 505                 510         


Ser Ala Ala Ala 
        515     


<210>  25
<211>  2283
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG1497 (LP-LTG1497-CD8 TM-41BB-CD3zeta) or (LP-CD20 
       VH-(GGGGS)3-CD20 VL-(GGGGS)5-CD19VL-Whitlow linker-CD19 VH-CD8 
       hinge+TM-41BB-CD3zeta)

<400>  25
atgctccttc tcgtgacctc cctgcttctc tgcgaactgc cccatcctgc cttcctgctg       60

attcccgagg tgcagttgca acagtcagga gctgaactgg tcaagccagg agccagcgtg      120

aagatgagct gcaaggcctc cggttacacc ttcacctcct acaacatgca ctgggtgaaa      180

cagaccccgg gacaagggct cgaatggatt ggcgccatct accccgggaa tggcgatact      240

tcgtacaacc agaagttcaa gggaaaggcc accctgaccg ccgacaagag ctcctccacc      300

gcgtatatgc agttgagctc cctgacctcc gaggactccg ccgactacta ctgcgcacgg      360

tccaactact atggaagctc gtactggttc ttcgatgtct ggggggccgg caccactgtg      420

accgtcagct ccgggggcgg aggatccggt ggaggcggaa gcgggggtgg aggatccgac      480

attgtgctga ctcagtcccc ggcaatcctg tcggcctcac cgggcgaaaa ggtcacgatg      540

acttgtagag cgtcgtccag cgtgaactac atggattggt accaaaagaa gcctggatcg      600

tcacccaagc cttggatcta cgctacatct aacctggcct ccggcgtgcc agcgcggttc      660

agcgggtccg gctcgggcac ctcatactcg ctgaccatct cccgcgtgga ggctgaggac      720

gccgcgacct actactgcca gcagtggtcc ttcaacccgc cgacttttgg aggcggtact      780

aagctggaga tcaaaggagg cggcggcagc ggcgggggag ggtccggagg gggtggttct      840

ggtggaggag gatcgggagg cggtggcagc gacattcaga tgactcagac cacctcctcc      900

ctgtccgcct ccctgggcga ccgcgtgacc atctcatgcc gcgccagcca ggacatctcg      960

aagtacctca actggtacca gcagaagccc gacggaaccg tgaagctcct gatctaccac     1020

acctcccggc tgcacagcgg agtgccgtct agattctcgg gttcggggtc gggaactgac     1080

tactccctta ctatttccaa cctggagcag gaggatattg ccacctactt ctgccaacaa     1140

ggaaacaccc tgccgtacac ttttggcggg ggaaccaagc tggaaatcac tggcagcaca     1200

tccggttccg ggaagcccgg ctccggagag ggcagcacca agggggaagt caagctgcag     1260

gaatcaggac ctggcctggt ggccccgagc cagtcactgt ccgtgacttg tactgtgtcc     1320

ggagtgtcgc tcccggatta cggagtgtcc tggatcaggc agccacctcg gaaaggattg     1380

gaatggctcg gagtcatctg gggttccgaa accacctatt acaactcggc actgaaatcc     1440

aggctcacca ttatcaagga taactccaag tcacaagtgt tcctgaagat gaatagcctg     1500

cagactgacg acacggcgat ctactattgc gccaagcact actactacgg cggatcctac     1560

gctatggact actggggcca ggggaccagc gtgaccgtgt catccgcggc cgcaactacc     1620

acccctgccc ctcggccgcc gactccggcc ccaaccatcg caagccaacc cctctccttg     1680

cgccccgaag cttgccgccc ggccgcgggt ggagccgtgc atacccgggg gctggacttt     1740

gcctgcgata tctacatttg ggccccgctg gccggcactt gcggcgtgct cctgctgtcg     1800

ctggtcatca ccctttactg caagaggggc cggaagaagc tgctttacat cttcaagcag     1860

ccgttcatgc ggcccgtgca gacgactcag gaagaggacg gatgctcgtg cagattccct     1920

gaggaggaag aggggggatg cgaactgcgc gtcaagttct cacggtccgc cgacgccccc     1980

gcatatcaac agggccagaa tcagctctac aacgagctga acctgggaag gagagaggag     2040

tacgacgtgc tggacaagcg acgcggacgc gacccggaga tgggggggaa accacggcgg     2100

aaaaaccctc aggaaggact gtacaacgaa ctccagaaag acaagatggc ggaagcctac     2160

tcagaaatcg ggatgaaggg agagcggagg aggggaaagg gtcacgacgg gctgtaccag     2220

ggactgagca ccgccactaa ggatacctac gatgccttgc atatgcaagc actcccaccc     2280

cgg                                                                   2283


<210>  26
<211>  761
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG1497 (LP-LTG1497-CD8 TM-41BB-CD3zeta) or (LP-CD20 VH 
       (GGGGS)3-CD20 VL-(GGGGS)5-CD19 VL-Whitlow linker-CD19 VH-CD8 
       hinge+TM-41BB-CD3zeta)

<400>  26

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
        115                 120                 125             


Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
                165                 170                 175     


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
            180                 185                 190         


Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
        195                 200                 205             


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
225                 230                 235                 240 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
    290                 295                 300                 


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
305                 310                 315                 320 


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
                325                 330                 335     


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
        355                 360                 365             


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
    370                 375                 380                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr 
385                 390                 395                 400 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
                405                 410                 415     


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
            420                 425                 430         


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
        435                 440                 445             


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
    450                 455                 460                 


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
465                 470                 475                 480 


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
                485                 490                 495     


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
            500                 505                 510         


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        515                 520                 525             


Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                565                 570                 575     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            580                 585                 590         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        595                 600                 605             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    610                 615                 620                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
625                 630                 635                 640 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                645                 650                 655     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            660                 665                 670         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        675                 680                 685             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    690                 695                 700                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
705                 710                 715                 720 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                725                 730                 735     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            740                 745                 750         


Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760     


<210>  27
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  27
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  28
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  28

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  29
<211>  1485
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG 1494 (LP-CD19binder-CD8link-CD8tm-41BB-CD3zeta)

<400>  29
atgcttctcc tggtcacctc cctgctcctc tgcgaactgc ctcaccctgc cttccttctg       60

attcctgaca ctgacattca gatgactcag accacctctt ccttgtccgc gtcactggga      120

gacagagtga ccatctcgtg tcgcgcaagc caggatatct ccaagtacct gaactggtac      180

caacagaagc ccgacgggac tgtgaagctg ctgatctacc acacctcacg cctgcacagc      240

ggagtgccaa gcagattctc cggctccggc tcgggaaccg attactcgct taccattagc      300

aacctcgagc aggaggacat cgctacctac ttctgccagc aaggaaatac cctgccctac      360

accttcggcg gaggaaccaa attggaaatc accggctcca cgagcggctc cgggaagcct      420

ggttccgggg aaggctccac taagggtgaa gtgaagctcc aggagtccgg ccccggcctg      480

gtggcgccgt cgcaatcact ctctgtgacc tgtaccgtgt cgggagtgtc cctgcctgat      540

tacggcgtga gctggattcg gcagccgccg cggaagggcc tggaatggct gggtgtcatc      600

tggggatccg agactaccta ctacaactcg gccctgaagt cccgcctgac tatcatcaaa      660

gacaactcga agtcccaggt ctttctgaag atgaactccc tgcaaactga cgacaccgcc      720

atctattact gtgctaagca ctactactac ggtggaagct atgctatgga ctactggggc      780

caggggacat ccgtgacagt cagctccgcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  30
<211>  495
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG1494 (LP-CD19binder-CD8link-CD8tm-41BB-CD3zeta)

<400>  30

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Thr Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu 
145                 150                 155                 160 


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  31
<211>  1470
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG1538 (LP-CD19binder-CD8link-CD8tm-signals (LTI 
       re-engineered CD19 CAR)

<400>  31
atgcttctcc tggtcacctc cctgctcctc tgcgaactgc ctcaccctgc cttccttctg       60

attcctgaca ttcagatgac tcagaccacc tcttccttgt ccgcgtcact gggagacaga      120

gtgaccatct cgtgtcgcgc aagccaggat atctccaagt acctgaactg gtaccaacag      180

aagcccgacg ggactgtgaa gctgctgatc taccacacct cacgcctgca cagcggagtg      240

ccaagcagat tctccggctc cggctcggga accgattact cgcttaccat tagcaacctc      300

gagcaggagg acatcgctac ctacttctgc cagcaaggaa ataccctgcc ctacaccttc      360

ggcggaggaa ccaaattgga aatcaccggc ggaggaggct ccgggggagg aggttccggg      420

ggcgggggtt ccgaagtgaa gctccaggag tccggccccg gcctggtggc gccgtcgcaa      480

tcactctctg tgacctgtac cgtgtcggga gtgtccctgc ctgattacgg cgtgagctgg      540

attcggcagc cgccgcggaa gggcctggaa tggctgggtg tcatctgggg atccgagact      600

acctactaca actcggccct gaagtcccgc ctgactatca tcaaagacaa ctcgaagtcc      660

caggtctttc tgaagatgaa ctccctgcaa actgacgaca ccgccatcta ttactgtgct      720

aagcactact actacggtgg aagctatgct atggactact gggggcaagg cacttcggtg      780

actgtgtcaa gcgcggccgc aactaccacc cctgcccctc ggccgccgac tccggcccca      840

accatcgcaa gccaacccct ctccttgcgc cccgaagctt gccgcccggc cgcgggtgga      900

gccgtgcata cccgggggct ggactttgcc tgcgatatct acatttgggc cccgctggcc      960

ggcacttgcg gcgtgctcct gctgtcgctg gtcatcaccc tttactgcaa gaggggccgg     1020

aagaagctgc tttacatctt caagcagccg ttcatgcggc ccgtgcagac gactcaggaa     1080

gaggacggat gctcgtgcag attccctgag gaggaagagg ggggatgcga actgcgcgtc     1140

aagttctcac ggtccgccga cgcccccgca tatcaacagg gccagaatca gctctacaac     1200

gagctgaacc tgggaaggag agaggagtac gacgtgctgg acaagcgacg cggacgcgac     1260

ccggagatgg gggggaaacc acggcggaaa aaccctcagg aaggactgta caacgaactc     1320

cagaaagaca agatggcgga agcctactca gaaatcggga tgaagggaga gcggaggagg     1380

ggaaagggtc acgacgggct gtaccaggga ctgagcaccg ccactaagga tacctacgat     1440

gccttgcata tgcaagcact cccaccccgg                                      1470


<210>  32
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG1538 (LP-CD19binder-CD8link-CD8tm-signals (LTI 
       re-engineered CD19 CAR)

<400>  32

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
                165                 170                 175     


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
            180                 185                 190         


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
        195                 200                 205             


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
    210                 215                 220                 


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  33
<211>  1548
<212>  DNA
<213>  Artificial

<220>
<223>  CD19_20-reactive scFv binding domain (LTG1496)

<400>  33
gacattcaga tgactcagac cacctcctcc ctgtccgcct ccctgggcga ccgcgtgacc       60

atctcatgcc gcgccagcca ggacatctcg aagtacctca actggtacca gcagaagccc      120

gacggaaccg tgaagctcct gatctaccac acctcccggc tgcacagcgg agtgccgtct      180

agattctcgg gttcggggtc gggaactgac tactccctta ctatttccaa cctggagcag      240

gaggatattg ccacctactt ctgccaacaa ggaaacaccc tgccgtacac ttttggcggg      300

ggaaccaagc tggaaatcac tggcagcaca tccggttccg ggaagcccgg ctccggagag      360

ggcagcacca agggggaagt caagctgcag gaatcaggac ctggcctggt ggccccgagc      420

cagtcactgt ccgtgacttg tactgtgtcc ggagtgtcgc tcccggatta cggagtgtcc      480

tggatcaggc agccacctcg gaaaggattg gaatggctcg gagtcatctg gggttccgaa      540

accacctatt acaactcggc actgaaatcc aggctcacca ttatcaagga taactccaag      600

tcacaagtgt tcctgaagat gaatagcctg cagactgacg acacggcgat ctactattgc      660

gccaagcact actactacgg cggatcctac gctatggact actggggcca ggggaccagc      720

gtgaccgtgt catccggagg cggcggcagc ggcgggggag ggtccggagg gggtggttct      780

ggtggaggag gatcgggagg cggtggcagc gaggtgcagt tgcaacagtc aggagctgaa      840

ctggtcaagc caggagccag cgtgaagatg agctgcaagg cctccggtta caccttcacc      900

tcctacaaca tgcactgggt gaaacagacc ccgggacaag ggctcgaatg gattggcgcc      960

atctaccccg ggaatggcga tacttcgtac aaccagaagt tcaagggaaa ggccaccctg     1020

accgccgaca agagctcctc caccgcgtat atgcagttga gctccctgac ctccgaggac     1080

tccgccgact actactgcgc acggtccaac tactatggaa gctcgtactg gttcttcgat     1140

gtctgggggg ccggcaccac tgtgaccgtc agctccgggg gcggaggatc cggtggaggc     1200

ggaagcgggg gtggaggatc cgacattgtg ctgactcagt ccccggcaat cctgtcggcc     1260

tcaccgggcg aaaaggtcac gatgacttgt agagcgtcgt ccagcgtgaa ctacatggat     1320

tggtaccaaa agaagcctgg atcgtcaccc aagccttgga tctacgctac atctaacctg     1380

gcctccggcg tgccagcgcg gttcagcggg tccggctcgg gcacctcata ctcgctgacc     1440

atctcccgcg tggaggctga ggacgccgcg acctactact gccagcagtg gtccttcaac     1500

ccgccgactt ttggaggcgg tactaagctg gagatcaaag cggccgca                  1548


<210>  34
<211>  516
<212>  PRT
<213>  Artificial

<220>
<223>  CD19_20-reactive scFv binding domain (LTG1496)

<400>  34

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
        275                 280                 285             


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
    290                 295                 300                 


His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala 
305                 310                 315                 320 


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
                325                 330                 335     


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
            340                 345                 350         


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys Ala Arg 
        355                 360                 365             


Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp Gly Ala 
    370                 375                 380                 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
                405                 410                 415     


Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala 
            420                 425                 430         


Ser Ser Ser Val Asn Tyr Met Asp Trp Tyr Gln Lys Lys Pro Gly Ser 
        435                 440                 445             


Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val 
    450                 455                 460                 


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
465                 470                 475                 480 


Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
                485                 490                 495     


Trp Ser Phe Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            500                 505                 510         


Lys Ala Ala Ala 
        515     


<210>  35
<211>  2283
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG1496 (LP-LTG1496-CD8 TM-41BB-CD3zeta) or (LP-CD19 
       VL-Whitlow linker-CD19 VH (GGGGS)5 CD20 VH (GGGGS)3-CD20 VL CD8 
       hinge+TM-41BB-CD3zeta)

<400>  35
atgctccttc tcgtgacctc cctgcttctc tgcgaactgc cccatcctgc cttcctgctg       60

attcccgaca ttcagatgac tcagaccacc tcctccctgt ccgcctccct gggcgaccgc      120

gtgaccatct catgccgcgc cagccaggac atctcgaagt acctcaactg gtaccagcag      180

aagcccgacg gaaccgtgaa gctcctgatc taccacacct cccggctgca cagcggagtg      240

ccgtctagat tctcgggttc ggggtcggga actgactact cccttactat ttccaacctg      300

gagcaggagg atattgccac ctacttctgc caacaaggaa acaccctgcc gtacactttt      360

ggcgggggaa ccaagctgga aatcactggc agcacatccg gttccgggaa gcccggctcc      420

ggagagggca gcaccaaggg ggaagtcaag ctgcaggaat caggacctgg cctggtggcc      480

ccgagccagt cactgtccgt gacttgtact gtgtccggag tgtcgctccc ggattacgga      540

gtgtcctgga tcaggcagcc acctcggaaa ggattggaat ggctcggagt catctggggt      600

tccgaaacca cctattacaa ctcggcactg aaatccaggc tcaccattat caaggataac      660

tccaagtcac aagtgttcct gaagatgaat agcctgcaga ctgacgacac ggcgatctac      720

tattgcgcca agcactacta ctacggcgga tcctacgcta tggactactg gggccagggg      780

accagcgtga ccgtgtcatc cggaggcggc ggcagcggcg ggggagggtc cggagggggt      840

ggttctggtg gaggaggatc gggaggcggt ggcagcgagg tgcagttgca acagtcagga      900

gctgaactgg tcaagccagg agccagcgtg aagatgagct gcaaggcctc cggttacacc      960

ttcacctcct acaacatgca ctgggtgaaa cagaccccgg gacaagggct cgaatggatt     1020

ggcgccatct accccgggaa tggcgatact tcgtacaacc agaagttcaa gggaaaggcc     1080

accctgaccg ccgacaagag ctcctccacc gcgtatatgc agttgagctc cctgacctcc     1140

gaggactccg ccgactacta ctgcgcacgg tccaactact atggaagctc gtactggttc     1200

ttcgatgtct ggggggccgg caccactgtg accgtcagct ccgggggcgg aggatccggt     1260

ggaggcggaa gcgggggtgg aggatccgac attgtgctga ctcagtcccc ggcaatcctg     1320

tcggcctcac cgggcgaaaa ggtcacgatg acttgtagag cgtcgtccag cgtgaactac     1380

atggattggt accaaaagaa gcctggatcg tcacccaagc cttggatcta cgctacatct     1440

aacctggcct ccggcgtgcc agcgcggttc agcgggtccg gctcgggcac ctcatactcg     1500

ctgaccatct cccgcgtgga ggctgaggac gccgcgacct actactgcca gcagtggtcc     1560

ttcaacccgc cgacttttgg aggcggtact aagctggaga tcaaagcggc cgcaactacc     1620

acccctgccc ctcggccgcc gactccggcc ccaaccatcg caagccaacc cctctccttg     1680

cgccccgaag cttgccgccc ggccgcgggt ggagccgtgc atacccgggg gctggacttt     1740

gcctgcgata tctacatttg ggccccgctg gccggcactt gcggcgtgct cctgctgtcg     1800

ctggtcatca ccctttactg caagaggggc cggaagaagc tgctttacat cttcaagcag     1860

ccgttcatgc ggcccgtgca gacgactcag gaagaggacg gatgctcgtg cagattccct     1920

gaggaggaag aggggggatg cgaactgcgc gtcaagttct cacggtccgc cgacgccccc     1980

gcatatcaac agggccagaa tcagctctac aacgagctga acctgggaag gagagaggag     2040

tacgacgtgc tggacaagcg acgcggacgc gacccggaga tgggggggaa accacggcgg     2100

aaaaaccctc aggaaggact gtacaacgaa ctccagaaag acaagatggc ggaagcctac     2160

tcagaaatcg ggatgaaggg agagcggagg aggggaaagg gtcacgacgg gctgtaccag     2220

ggactgagca ccgccactaa ggatacctac gatgccttgc atatgcaagc actcccaccc     2280

cgg                                                                   2283


<210>  36
<211>  761
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG1496 (LP-LTG1496-CD8 TM-41BB-CD3zeta) or (LP-CD19 
       VL-Whitlow linker-CD19 VH-(GGGGS)5-CD20 VH (GGGGS)3-CD20 VL-CD8 
       hinge+TM-41BB-CD3zeta)

<400>  36

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
    290                 295                 300                 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
305                 310                 315                 320 


Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly 
                325                 330                 335     


Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
            340                 345                 350         


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
        355                 360                 365             


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
    370                 375                 380                 


Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe 
385                 390                 395                 400 


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
            420                 425                 430         


Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val 
        435                 440                 445             


Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp Trp Tyr 
    450                 455                 460                 


Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser 
465                 470                 475                 480 


Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
                485                 490                 495     


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala 
            500                 505                 510         


Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gly 
        515                 520                 525             


Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                565                 570                 575     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            580                 585                 590         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        595                 600                 605             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    610                 615                 620                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
625                 630                 635                 640 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                645                 650                 655     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            660                 665                 670         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        675                 680                 685             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    690                 695                 700                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
705                 710                 715                 720 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                725                 730                 735     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            740                 745                 750         


Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760     


<210>  37
<211>  732
<212>  DNA
<213>  Artificial

<220>
<223>  mesothelin-reactive scFv binding domain (LTG1904)

<400>  37
gaggtccagc tggtacagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagattta      300

tcgtcagtgg ctggaccctt taactactgg ggccagggca ccctggtcac cgtctcctca      360

ggaggtggcg ggtctggtgg aggcggtagc ggcggtggcg gatcctcttc tgagctgact      420

caggaccctg ctgtgtctgt ggccttggga cagacagtca ggatcacatg ccaaggagac      480

agcctcagaa gctattatgc aagctggtac cagcagaagc caggacaggc ccctgtactt      540

gtcatctatg gtaaaaacaa ccggccctca gggatcccag accgattctc tggctccagc      600

tcaggaaaca cagcttcctt gaccatcact ggggctcagg cggaggatga ggctgactat      660

tactgtaact cccgggacag cagtggtaac catctggtat tcggcggagg cacccagctg      720

accgtcctcg gt                                                          732


<210>  38
<211>  244
<212>  PRT
<213>  Artificial

<220>
<223>  mesothelin-reactive scFv binding domain (LTG1904)

<400>  38

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Ser Ser Val Ala Gly Pro Phe Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
    210                 215                 220                 


Arg Asp Ser Ser Gly Asn His Leu Val Phe Gly Gly Gly Thr Gln Leu 
225                 230                 235                 240 


Thr Val Leu Gly 
                


<210>  39
<211>  1476
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG1904 (LP-LTG1904-CD8 TM-41BB-CD3zeta)

<400>  39
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctggg ggaggcttgg tacagcctgg ggggtccctg      120

agactctcct gtgcagcctc tggattcacc tttgatgatt atgccatgca ctgggtccgg      180

caagctccag ggaagggcct ggagtgggtc tcaggtatta gttggaatag tggtagcata      240

ggctatgcgg actctgtgaa gggccgattc accatctcca gagacaacgc caagaactcc      300

ctgtatctgc aaatgaacag tctgagagct gaggacacgg ccttgtatta ctgtgcaaaa      360

gatttatcgt cagtggctgg accctttaac tactggggcc agggcaccct ggtcaccgtc      420

tcctcaggag gtggcgggtc tggtggaggc ggtagcggcg gtggcggatc ctcttctgag      480

ctgactcagg accctgctgt gtctgtggcc ttgggacaga cagtcaggat cacatgccaa      540

ggagacagcc tcagaagcta ttatgcaagc tggtaccagc agaagccagg acaggcccct      600

gtacttgtca tctatggtaa aaacaaccgg ccctcaggga tcccagaccg attctctggc      660

tccagctcag gaaacacagc ttccttgacc atcactgggg ctcaggcgga ggatgaggct      720

gactattact gtaactcccg ggacagcagt ggtaaccatc tggtattcgg cggaggcacc      780

cagctgaccg tcctcggtgc ggccgcaact accacccctg cccctcggcc gccgactccg      840

gccccaacca tcgcaagcca acccctctcc ttgcgccccg aagcttgccg cccggccgcg      900

ggtggagccg tgcatacccg ggggctggac tttgcctgcg atatctacat ttgggccccg      960

ctggccggca cttgcggcgt gctcctgctg tcgctggtca tcacccttta ctgcaagagg     1020

ggccggaaga agctgcttta catcttcaag cagccgttca tgcggcccgt gcagacgact     1080

caggaagagg acggatgctc gtgcagattc cctgaggagg aagagggggg atgcgaactg     1140

cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc     1200

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga     1260

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac     1320

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg     1380

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc     1440

tacgatgcct tgcatatgca agcactccca ccccgg                               1476


<210>  40
<211>  492
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG1904 (LP-LTG1904-CD8 TM-41BB-CD3zeta)

<400>  40

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile 
65                  70                  75                  80  


Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Leu Ser Ser Val Ala Gly Pro 
        115                 120                 125             


Phe Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Glu 
145                 150                 155                 160 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
                165                 170                 175     


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        195                 200                 205             


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Leu Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  41
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  CD33-reactive single chain binding domain VH-4 (LTG1906)

<400>  41
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgagctgggt ccgccaggct      120

ccaagacaag ggcttgagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gcggactcag tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acagccacgt attactgtgc gaaagaaaat      300

gtggactggg gccagggcac cctggtcacc gtctcctca                             339


<210>  42
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  CD33-reactive single chain binding domain VH-4 (LTG1906)

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Arg Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Asn Val Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  43
<211>  1083
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG1906 (LP-VH4-CD8 TM-41BB-CD3zeta)

<400>  43
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tgcagctggt ggagtctggg ggaggcttgg tacagcctgg agggtccctg      120

agactctcct gtgcagcctc tggattcacc ttcagtagct atggcatgag ctgggtccgc      180

caggctccaa gacaagggct tgagtgggtg gccaacataa agcaagatgg aagtgagaaa      240

tactatgcgg actcagtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagcc gaggacacag ccacgtatta ctgtgcgaaa      360

gaaaatgtgg actggggcca gggcaccctg gtcaccgtct cctcagcggc cgcaactacc      420

acccctgccc ctcggccgcc gactccggcc ccaaccatcg caagccaacc cctctccttg      480

cgccccgaag cttgccgccc ggccgcgggt ggagccgtgc atacccgggg gctggacttt      540

gcctgcgata tctacatttg ggccccgctg gccggcactt gcggcgtgct cctgctgtcg      600

ctggtcatca ccctttactg caagaggggc cggaagaagc tgctttacat cttcaagcag      660

ccgttcatgc ggcccgtgca gacgactcag gaagaggacg gatgctcgtg cagattccct      720

gaggaggaag aggggggatg cgaactgcgc gtcaagttct cacggtccgc cgacgccccc      780

gcatatcaac agggccagaa tcagctctac aacgagctga acctgggaag gagagaggag      840

tacgacgtgc tggacaagcg acgcggacgc gacccggaga tgggggggaa accacggcgg      900

aaaaaccctc aggaaggact gtacaacgaa ctccagaaag acaagatggc ggaagcctac      960

tcagaaatcg ggatgaaggg agagcggagg aggggaaagg gtcacgacgg gctgtaccag     1020

ggactgagca ccgccactaa ggatacctac gatgccttgc atatgcaagc actcccaccc     1080

cgg                                                                   1083


<210>  44
<211>  361
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG1906 (LP-VH4-CD8 TM-41BB-CD3zeta)

<400>  44

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Arg 
    50                  55                  60                  


Gln Gly Leu Glu Trp Val Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Thr Tyr Tyr Cys Ala Lys Glu Asn Val Asp Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    130                 135                 140                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
145                 150                 155                 160 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                165                 170                 175     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            180                 185                 190         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        195                 200                 205             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    210                 215                 220                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
225                 230                 235                 240 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                245                 250                 255     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            260                 265                 270         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        275                 280                 285             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    290                 295                 300                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
305                 310                 315                 320 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                325                 330                 335     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            340                 345                 350         


Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360     


<210>  45
<211>  797
<212>  DNA
<213>  Artificial

<220>
<223>  TSLPR-reactive scFv binding domain (LTG1789)

<400>  45
atggcactgc ccgtgaccgc cctgcttctg ccgcttgcac ttctgctgca cgccgctagg       60

ccccaagtca ccctcaaaga gtcagggcca ggaatcctca agccctcaca gactctgtct      120

cttacttgct cattcagcgg attcagcctt tccacctctg gtatgggcgt ggggtggatt      180

aggcaaccta gcggaaaggg gcttgaatgg ctggcccaca tctggtggga cgacgacaag      240

tactacaacc cctcactgaa gtcccagctc actatttcca aagatacttc ccggaatcag      300

gtgttcctca agattacctc tgtcgacacc gctgataccg ccacttacta ttgttcacgc      360

agaccgagag gtaccatgga cgcaatggac tactggggac agggcaccag cgtgaccgtg      420

tcatctggcg gtggagggtc aggaggtgga ggtagcggag gcggtgggtc cgacattgtc      480

atgacccagg ccgccagcag cctgagcgct tcactgggcg acagggtgac catcagctgt      540

cgcgcatcac aagatatctc taagtatctt aattggtacc agcaaaagcc ggatggaacc      600

gtgaagctgc tgatctacta cacctcacgg ctgcattctg gagtgcctag ccgctttagc      660

ggatctgggt ccggtactga ctacagcctc accattagaa accttgaaca ggaggacatc      720

gcaacttatt tctgccaaca ggtctatact ctgccgtgga ccttcggcgg aggtaccaaa      780

ctggagatta agtccgg                                                     797


<210>  46
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  TSLPR-reactive scFv binding domain (LTG1789)

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile 
            20                  25                  30          


Leu Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Tyr Tyr Asn Pro Ser Leu Lys Ser Gln Leu Thr Ile Ser Lys Asp Thr 
                85                  90                  95      


Ser Arg Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp 
            100                 105                 110         


Thr Ala Thr Tyr Tyr Cys Ser Arg Arg Pro Arg Gly Thr Met Asp Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Gln Glu Asp Ile 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Gln Gln Val Tyr Thr Leu Pro Trp Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Lys Ser 
            260                 265 


<210>  47
<211>  1170
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG1789 (LP-3G11-CD8 TM-41BB-CD3zeta)

<400>  47
atggcactgc ccgtgaccgc cctgcttctg ccgcttgcac ttctgctgca cgccgctagg       60

ccccaagtca ccctcaaaga gtcagggcca ggaatcctca agccctcaca gactctgtct      120

cttacttgct cattcagcgg attcagcctt tccacctctg gtatgggcgt ggggtggatt      180

aggcaaccta gcggaaaggg gcttgaatgg ctggcccaca tctggtggga cgacgacaag      240

tactacaacc cctcactgaa gtcccagctc actatttcca aagatacttc ccggaatcag      300

gtgttcctca agattacctc tgtcgacacc gctgataccg ccacttacta ttgttcacgc      360

agaccgagag gtaccatgga cgcaatggac tactggggac agggcaccag cgtgaccgtg      420

tcatctggcg gtggagggtc aggaggtgga ggtagcggag gcggtgggtc cgacattgtc      480

atgacccagg ccgccagcag cctgagcgct tcactgggcg acagggtgac catcagctgt      540

cgcgcatcac aagatatctc taagtatctt aattggtacc agcaaaagcc ggatggaacc      600

gtgaagctgc tgatctacta cacctcacgg ctgcattctg gagtgcctag ccgctttagc      660

ggcacttgcg gcgtgctcct gctgtcgctg gtcatcaccc tttactgcaa gaggggccgg      720

aagaagctgc tttacatctt caagcagccg ttcatgcggc ccgtgcagac gactcaggaa      780

gaggacggat gctcgtgcag attccctgag gaggaagagg ggggatgcga actgcgcgtc      840

aagttctcac ggtccgccga cgcccccgca tatcaacagg gccagaatca gctctacaac      900

gagctgaacc tgggaaggag agaggagtac gacgtgctgg acaagcgacg cggacgcgac      960

ccggagatgg gggggaaacc acggcggaaa aaccctcagg aaggactgta caacgaactc     1020

cagaaagaca agatggcgga agcctactca gaaatcggga tgaagggaga gcggaggagg     1080

ggaaagggtc acgacgggct gtaccaggga ctgagcaccg ccactaagga tacctacgat     1140

gccttgcata tgcaagcact cccaccccgg                                      1170


<210>  48
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG1789 (LP-3G11-CD8 TM-41BB-CD3zeta)

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile 
            20                  25                  30          


Leu Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Tyr Tyr Asn Pro Ser Leu Lys Ser Gln Leu Thr Ile Ser Lys Asp Thr 
                85                  90                  95      


Ser Arg Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp 
            100                 105                 110         


Thr Ala Thr Tyr Tyr Cys Ser Arg Arg Pro Arg Gly Thr Met Asp Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Gln Glu Asp Ile 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Gln Gln Val Tyr Thr Leu Pro Trp Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  49
<211>  1467
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG1563 (LP-CD19-TNFRSF19TM-41BB-CD3zeta)

<400>  49
atgctgctgc tggtcaccag cctgctgctg tgcgagctcc ctcaccccgc ctttctgctt       60

atcccggaca ttcagatgac acagaccacc tcgagcttgt ccgcgtcgct gggcgatcgc      120

gtgaccatct cctgccgggc ctcccaagac atttcaaagt atctcaactg gtaccagcag      180

aagccggacg gaaccgtgaa actgctgatc taccatacca gccgcctgca ctccggcgtg      240

ccgtcccgct tctccggatc gggttccgga actgactact cactgactat ctccaacttg      300

gaacaagagg acatcgccac ttacttctgt caacaaggaa atacccttcc ctacaccttc      360

ggggggggta ccaagctgga gatcactggg ggcggaggct ccggtggagg cggatccggc      420

ggtggaggga gcgaagtcaa gctgcaggaa tcaggaccag gactcgtggc gccatcccag      480

tccctgtcgg tgacctgtac tgtctccgga gtcagcctcc ccgattacgg agtgtcatgg      540

attaggcaac ccccaagaaa agggctggaa tggctcggag tgatctgggg ctccgaaacc      600

acctactaca actcggcgct gaagtcccgg ctgaccatca tcaaggacaa ctccaagagc      660

caagtgttct tgaagatgaa cagcttgcag accgacgata ccgcaatcta ctactgtgcc      720

aagcactatt actacggggg gtcttacgcc atggactact ggggacaggg cacctccgtg      780

actgtgtcgt ccgcggccgc gcccgcccct cggcccccga ctcctgcccc gacgatcgct      840

tcccaacctc tctcgctgcg cccggaagca tgccggcccg ccgccggtgg cgctgtccac      900

actcgcggac tggactttga taccgcactg gcggccgtga tctgtagcgc cctggccacc      960

gtgctgctgg cgctgctcat cctttgcgtg atctactgca agcggcagcc taggcgaaag     1020

aagctcctct acattttcaa gcaacccttc atgcgccccg tgcaaaccac ccaggaggag     1080

gatggatgct catgccggtt ccctgaggaa gaagagggcg gttgcgagct cagagtgaaa     1140

ttcagccggt cggctgacgc cccggcgtac cagcagggcc agaaccagct gtacaatgag     1200

ctcaacctgg ggcgccgcga agagtacgac gtgctggaca agaggagagg cagagatccg     1260

gaaatgggcg gaaagccaag gcggaagaac ccgcaggaag gtctttacaa cgaactgcag     1320

aaggacaaga tggccgaggc ctactccgag attgggatga agggagaaag acggagggga     1380

aagggacatg acggacttta ccagggcctg agcactgcca cgaaggacac ctatgatgcc     1440

ctgcacatgc aggcgctgcc gcctcgg                                         1467


<210>  50
<211>  489
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG1563 (LP-CD19-TNFRSF19TM-41BB-CD3zeta)

<400>  50

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
                165                 170                 175     


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
            180                 185                 190         


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
        195                 200                 205             


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
    210                 215                 220                 


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Asp Thr Ala Leu Ala Ala Val Ile Cys Ser Ala Leu Ala Thr 
305                 310                 315                 320 


Val Leu Leu Ala Leu Leu Ile Leu Cys Val Ile Tyr Cys Lys Arg Gln 
                325                 330                 335     


Pro Arg Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  51
<211>  2280
<212>  DNA
<213>  Artificial

<220>
<223>  CAR LTG2228 (LP-CD20_CD19-CD8TM-CD28-CD3zeta)

<400>  51
atgctccttc tcgtgacctc cctgcttctc tgcgaactgc cccatcctgc cttcctgctg       60

attcccgagg tgcagttgca acagtcagga gctgaactgg tcaagccagg agccagcgtg      120

aagatgagct gcaaggcctc cggttacacc ttcacctcct acaacatgca ctgggtgaaa      180

cagaccccgg gacaagggct cgaatggatt ggcgccatct accccgggaa tggcgatact      240

tcgtacaacc agaagttcaa gggaaaggcc accctgaccg ccgacaagag ctcctccacc      300

gcgtatatgc agttgagctc cctgacctcc gaggactccg ccgactacta ctgcgcacgg      360

tccaactact atggaagctc gtactggttc ttcgatgtct ggggggccgg caccactgtg      420

accgtcagct ccgggggcgg aggatccggt ggaggcggaa gcgggggtgg aggatccgac      480

attgtgctga ctcagtcccc ggcaatcctg tcggcctcac cgggcgaaaa ggtcacgatg      540

acttgtagag cgtcgtccag cgtgaactac atggattggt accaaaagaa gcctggatcg      600

tcacccaagc cttggatcta cgctacatct aacctggcct ccggcgtgcc agcgcggttc      660

agcgggtccg gctcgggcac ctcatactcg ctgaccatct cccgcgtgga ggctgaggac      720

gccgcgacct actactgcca gcagtggtcc ttcaacccgc cgacttttgg aggcggtact      780

aagctggaga tcaaaggagg cggcggcagc ggcgggggag ggtccggagg gggtggttct      840

ggtggaggag gatcgggagg cggtggcagc gacattcaga tgactcagac cacctcctcc      900

ctgtccgcct ccctgggcga ccgcgtgacc atctcatgcc gcgccagcca ggacatctcg      960

aagtacctca actggtacca gcagaagccc gacggaaccg tgaagctcct gatctaccac     1020

acctcccggc tgcacagcgg agtgccgtct agattctcgg gttcggggtc gggaactgac     1080

tactccctta ctatttccaa cctggagcag gaggatattg ccacctactt ctgccaacaa     1140

ggaaacaccc tgccgtacac ttttggcggg ggaaccaagc tggaaatcac tggcagcaca     1200

tccggttccg ggaagcccgg ctccggagag ggcagcacca agggggaagt caagctgcag     1260

gaatcaggac ctggcctggt ggccccgagc cagtcactgt ccgtgacttg tactgtgtcc     1320

ggagtgtcgc tcccggatta cggagtgtcc tggatcaggc agccacctcg gaaaggattg     1380

gaatggctcg gagtcatctg gggttccgaa accacctatt acaactcggc actgaaatcc     1440

aggctcacca ttatcaagga taactccaag tcacaagtgt tcctgaagat gaatagcctg     1500

cagactgacg acacggcgat ctactattgc gccaagcact actactacgg cggatcctac     1560

gctatggact actggggcca ggggaccagc gtgaccgtgt catccgcggc cgcgactacc     1620

actcctgcac cacggccacc taccccagcc cccaccattg caagccagcc actttcactg     1680

cgccccgaag cgtgtagacc agctgctgga ggagccgtgc atacccgagg gctggacttc     1740

gcctgtgaca tctacatctg ggccccattg gctggaactt gcggcgtgct gctcttgtct     1800

ctggtcatta ccctgtactg ccggtcgaag aggtccagac tcttgcactc cgactacatg     1860

aacatgactc ctagaaggcc cggacccact agaaagcact accagccgta cgcccctcct     1920

cgggatttcg ccgcataccg gtccagagtg aagttcagcc gctcagccga tgcaccggcc     1980

taccagcagg gacagaacca gctctacaac gagctcaacc tgggtcggcg ggaagaatat     2040

gacgtgctgg acaaacggcg cggcagagat ccggagatgg ggggaaagcc gaggaggaag     2100

aaccctcaag agggcctgta caacgaactg cagaaggaca agatggcgga agcctactcc     2160

gagatcggca tgaagggaga acgccggaga gggaagggtc atgacggact gtaccagggc     2220

ctgtcaactg ccactaagga cacttacgat gcgctccata tgcaagcttt gcccccgcgg     2280


<210>  52
<211>  760
<212>  PRT
<213>  Artificial

<220>
<223>  CAR LTG2228 (LP-CD20_CD19-CD8TM-CD28-CD3zeta)

<400>  52

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
        115                 120                 125             


Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
                165                 170                 175     


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
            180                 185                 190         


Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
        195                 200                 205             


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
225                 230                 235                 240 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
    290                 295                 300                 


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
305                 310                 315                 320 


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
                325                 330                 335     


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
        355                 360                 365             


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
    370                 375                 380                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr 
385                 390                 395                 400 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
                405                 410                 415     


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
            420                 425                 430         


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
        435                 440                 445             


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
    450                 455                 460                 


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
465                 470                 475                 480 


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
                485                 490                 495     


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
            500                 505                 510         


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        515                 520                 525             


Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                565                 570                 575     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            580                 585                 590         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
        595                 600                 605             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    610                 615                 620                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
625                 630                 635                 640 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
                645                 650                 655     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            660                 665                 670         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        675                 680                 685             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    690                 695                 700                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
705                 710                 715                 720 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                725                 730                 735     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            740                 745                 750         


His Met Gln Ala Leu Pro Pro Arg 
        755                 760 


<210>  53
<211>  3858
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  53
atgctccttc tcgtgacctc cctgcttctc tgcgaactgc cccatcctgc cttcctgctg       60

attcccgagg tgcagttgca acagtcagga gctgaactgg tcaagccagg agccagcgtg      120

aagatgagct gcaaggcctc cggttacacc ttcacctcct acaacatgca ctgggtgaaa      180

cagaccccgg gacaagggct cgaatggatt ggcgccatct accccgggaa tggcgatact      240

tcgtacaacc agaagttcaa gggaaaggcc accctgaccg ccgacaagag ctcctccacc      300

gcgtatatgc agttgagctc cctgacctcc gaggactccg ccgactacta ctgcgcacgg      360

tccaactact atggaagctc gtactggttc ttcgatgtct ggggggccgg caccactgtg      420

accgtcagct ccgggggcgg aggatccggt ggaggcggaa gcgggggtgg aggatccgac      480

attgtgctga ctcagtcccc ggcaatcctg tcggcctcac cgggcgaaaa ggtcacgatg      540

acttgtagag cgtcgtccag cgtgaactac atggattggt accaaaagaa gcctggatcg      600

tcacccaagc cttggatcta cgctacatct aacctggcct ccggcgtgcc agcgcggttc      660

agcgggtccg gctcgggcac ctcatactcg ctgaccatct cccgcgtgga ggctgaggac      720

gccgcgacct actactgcca gcagtggtcc ttcaacccgc cgacttttgg aggcggtact      780

aagctggaga tcaaaggagg cggcggcagc ggcgggggag ggtccggagg gggtggttct      840

ggtggaggag gatcgggagg cggtggcagc gacattcaga tgactcagac cacctcctcc      900

ctgtccgcct ccctgggcga ccgcgtgacc atctcatgcc gcgccagcca ggacatctcg      960

aagtacctca actggtacca gcagaagccc gacggaaccg tgaagctcct gatctaccac     1020

acctcccggc tgcacagcgg agtgccgtct agattctcgg gttcggggtc gggaactgac     1080

tactccctta ctatttccaa cctggagcag gaggatattg ccacctactt ctgccaacaa     1140

ggaaacaccc tgccgtacac ttttggcggg ggaaccaagc tggaaatcac tggcagcaca     1200

tccggttccg ggaagcccgg ctccggagag ggcagcacca agggggaagt caagctgcag     1260

gaatcaggac ctggcctggt ggccccgagc cagtcactgt ccgtgacttg tactgtgtcc     1320

ggagtgtcgc tcccggatta cggagtgtcc tggatcaggc agccacctcg gaaaggattg     1380

gaatggctcg gagtcatctg gggttccgaa accacctatt acaactcggc actgaaatcc     1440

aggctcacca ttatcaagga taactccaag tcacaagtgt tcctgaagat gaatagcctg     1500

cagactgacg acacggcgat ctactattgc gccaagcact actactacgg cggatcctac     1560

gctatggact actggggcca ggggaccagc gtgaccgtgt catccgcggc cgcgactacc     1620

actcctgcac cacggccacc taccccagcc cccaccattg caagccagcc actttcactg     1680

cgccccgaag cgtgtagacc agctgctgga ggagccgtgc atacccgagg gctggacttc     1740

gcctgtgaca tctacatctg ggccccattg gctggaactt gcggcgtgct gctcttgtct     1800

ctggtcatta ccctgtactg ccggtcgaag aggtccagac tcttgcactc cgactacatg     1860

aacatgactc ctagaaggcc cggacccact agaaagcact accagccgta cgcccctcct     1920

cgggatttcg ccgcataccg gtccagagtg aagttcagcc gctcagccga tgcaccggcc     1980

taccagcagg gacagaacca gctctacaac gagctcaacc tgggtcggcg ggaagaatat     2040

gacgtgctgg acaaacggcg cggcagagat ccggagatgg ggggaaagcc gaggaggaag     2100

aaccctcaag agggcctgta caacgaactg cagaaggaca agatggcgga agcctactcc     2160

gagatcggca tgaagggaga acgccggaga gggaagggtc atgacggact gtaccagggc     2220

ctgtcaactg ccactaagga cacttacgat gcgctccata tgcaagcttt gcccccgcgg     2280

cgcgcgaaac gcggcagcgg cgcgaccaac tttagcctgc tgaaacaggc gggcgatgtg     2340

gaagaaaacc cgggcccgcg agcaaagagg aatattatgc ttctattagt gacttccctt     2400

ttgctgtgcg agttgccaca ccccgccttc ctgcttattc cccaggtaca gctccagcag     2460

agtggcccag ggctcgtgaa gccaagccag acgctgtccc tgacttgtgc aatttcaggg     2520

gattcagttt catcaaatag cgcggcgtgg aattggattc gacaatctcc ttcccgaggg     2580

ttggaatggc ttggacgaac atattacaga tccaaatggt ataacgacta tgcggtatca     2640

gtaaagtcaa gaataaccat taaccccgac acaagcaaga accaattctc tttgcagctt     2700

aactctgtca cgccagaaga cacggcagtc tattattgcg ctcgcgaggt aacgggtgac     2760

ctggaagacg cttttgacat ttgggggcag ggtacgatgg tgacagtcag ttcagggggc     2820

ggtgggagtg ggggaggggg tagcgggggg ggagggtcag acattcagat gacccagtcc     2880

ccttcatcct tgtctgcctc cgtcggtgac agggtgacaa taacatgcag agcaagccaa     2940

acaatctgga gctatctcaa ctggtaccag cagcgaccag gaaaagcgcc aaacctgctg     3000

atttacgctg cttcctccct ccaatcaggc gtgcctagta gatttagcgg taggggctcc     3060

ggcaccgatt ttacgctcac tataagctct cttcaagcag aagattttgc gacttattac     3120

tgccagcagt cctatagtat acctcagact ttcggacagg gtaccaagtt ggagattaag     3180

gctagcgcaa ccactacgcc tgctccgcgg cctccaacgc ccgcgcccac gatagctagt     3240

cagccgttgt ctctccgacc agaggcgtgt agaccggccg ctggcggagc cgtacatact     3300

cgcggactcg acttcgcttg cgacatctac atttgggcac ccttggctgg gacctgtggg     3360

gtgctgttgc tgtccttggt tattacgttg tactgcaaga ggggccggaa gaagctgctt     3420

tacatcttca agcagccgtt catgcggccc gtgcagacga ctcaggaaga ggacggatgc     3480

tcgtgcagat tccctgagga ggaagagggg ggatgcgaac tgagagtcaa attttccagg     3540

tccgcagatg cccccgcgta ccagcaaggc cagaaccaac tttacaacga actgaacctg     3600

ggtcgccggg aggaatatga tgtgctggat aaacgaaggg ggagggaccc tgagatggga     3660

gggaaacctc gcaggaaaaa cccgcaggaa ggtttgtaca acgagttgca gaaggataag     3720

atggctgagg cttactctga aatagggatg aagggagaga gacggagagg aaaaggccat     3780

gatggccttt accagggctt gagcacagca acaaaggata cttacgacgc tcttcacatg     3840

caagctctgc caccacgg                                                   3858


<210>  54
<211>  1286
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  54

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
        115                 120                 125             


Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
                165                 170                 175     


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
            180                 185                 190         


Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
        195                 200                 205             


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
225                 230                 235                 240 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
    290                 295                 300                 


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
305                 310                 315                 320 


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
                325                 330                 335     


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
        355                 360                 365             


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
    370                 375                 380                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr 
385                 390                 395                 400 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
                405                 410                 415     


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
            420                 425                 430         


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
        435                 440                 445             


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
    450                 455                 460                 


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
465                 470                 475                 480 


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
                485                 490                 495     


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
            500                 505                 510         


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        515                 520                 525             


Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                565                 570                 575     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            580                 585                 590         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
        595                 600                 605             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    610                 615                 620                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
625                 630                 635                 640 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
                645                 650                 655     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            660                 665                 670         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        675                 680                 685             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    690                 695                 700                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
705                 710                 715                 720 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                725                 730                 735     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            740                 745                 750         


His Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Gly Ser Gly Ala 
        755                 760                 765             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    770                 775                 780                 


Gly Pro Arg Ala Lys Arg Asn Ile Met Leu Leu Leu Val Thr Ser Leu 
785                 790                 795                 800 


Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Gln Val 
                805                 810                 815     


Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
            820                 825                 830         


Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala 
        835                 840                 845             


Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
    850                 855                 860                 


Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser 
865                 870                 875                 880 


Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe 
                885                 890                 895     


Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
            900                 905                 910         


Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp Ile Trp 
        915                 920                 925             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
945                 950                 955                 960 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                965                 970                 975     


Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu Asn Trp Tyr Gln Gln Arg 
            980                 985                 990         


Pro Gly Lys Ala Pro Asn Leu Leu  Ile Tyr Ala Ala Ser  Ser Leu Gln 
        995                 1000                 1005             


Ser Gly  Val Pro Ser Arg Phe  Ser Gly Arg Gly Ser  Gly Thr Asp 
    1010                 1015                 1020             


Phe Thr  Leu Thr Ile Ser Ser  Leu Gln Ala Glu Asp  Phe Ala Thr 
    1025                 1030                 1035             


Tyr Tyr  Cys Gln Gln Ser Tyr  Ser Ile Pro Gln Thr  Phe Gly Gln 
    1040                 1045                 1050             


Gly Thr  Lys Leu Glu Ile Lys  Ala Ser Ala Thr Thr  Thr Pro Ala 
    1055                 1060                 1065             


Pro Arg  Pro Pro Thr Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu 
    1070                 1075                 1080             


Ser Leu  Arg Pro Glu Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val 
    1085                 1090                 1095             


His Thr  Arg Gly Leu Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala 
    1100                 1105                 1110             


Pro Leu  Ala Gly Thr Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile 
    1115                 1120                 1125             


Thr Leu  Tyr Cys Lys Arg Gly  Arg Lys Lys Leu Leu  Tyr Ile Phe 
    1130                 1135                 1140             


Lys Gln  Pro Phe Met Arg Pro  Val Gln Thr Thr Gln  Glu Glu Asp 
    1145                 1150                 1155             


Gly Cys  Ser Cys Arg Phe Pro  Glu Glu Glu Glu Gly  Gly Cys Glu 
    1160                 1165                 1170             


Leu Arg  Val Lys Phe Ser Arg  Ser Ala Asp Ala Pro  Ala Tyr Gln 
    1175                 1180                 1185             


Gln Gly  Gln Asn Gln Leu Tyr  Asn Glu Leu Asn Leu  Gly Arg Arg 
    1190                 1195                 1200             


Glu Glu  Tyr Asp Val Leu Asp  Lys Arg Arg Gly Arg  Asp Pro Glu 
    1205                 1210                 1215             


Met Gly  Gly Lys Pro Arg Arg  Lys Asn Pro Gln Glu  Gly Leu Tyr 
    1220                 1225                 1230             


Asn Glu  Leu Gln Lys Asp Lys  Met Ala Glu Ala Tyr  Ser Glu Ile 
    1235                 1240                 1245             


Gly Met  Lys Gly Glu Arg Arg  Arg Gly Lys Gly His  Asp Gly Leu 
    1250                 1255                 1260             


Tyr Gln  Gly Leu Ser Thr Ala  Thr Lys Asp Thr Tyr  Asp Ala Leu 
    1265                 1270                 1275             


His Met  Gln Ala Leu Pro Pro  Arg 
    1280                 1285     


<210>  55
<211>  3852
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  55
atgctccttc tcgtgacctc cctgcttctc tgcgaactgc cccatcctgc cttcctgctg       60

attcccgagg tgcagttgca acagtcagga gctgaactgg tcaagccagg agccagcgtg      120

aagatgagct gcaaggcctc cggttacacc ttcacctcct acaacatgca ctgggtgaaa      180

cagaccccgg gacaagggct cgaatggatt ggcgccatct accccgggaa tggcgatact      240

tcgtacaacc agaagttcaa gggaaaggcc accctgaccg ccgacaagag ctcctccacc      300

gcgtatatgc agttgagctc cctgacctcc gaggactccg ccgactacta ctgcgcacgg      360

tccaactact atggaagctc gtactggttc ttcgatgtct ggggggccgg caccactgtg      420

accgtcagct ccgggggcgg aggatccggt ggaggcggaa gcgggggtgg aggatccgac      480

attgtgctga ctcagtcccc ggcaatcctg tcggcctcac cgggcgaaaa ggtcacgatg      540

acttgtagag cgtcgtccag cgtgaactac atggattggt accaaaagaa gcctggatcg      600

tcacccaagc cttggatcta cgctacatct aacctggcct ccggcgtgcc agcgcggttc      660

agcgggtccg gctcgggcac ctcatactcg ctgaccatct cccgcgtgga ggctgaggac      720

gccgcgacct actactgcca gcagtggtcc ttcaacccgc cgacttttgg aggcggtact      780

aagctggaga tcaaaggagg cggcggcagc ggcgggggag ggtccggagg gggtggttct      840

ggtggaggag gatcgggagg cggtggcagc gacattcaga tgactcagac cacctcctcc      900

ctgtccgcct ccctgggcga ccgcgtgacc atctcatgcc gcgccagcca ggacatctcg      960

aagtacctca actggtacca gcagaagccc gacggaaccg tgaagctcct gatctaccac     1020

acctcccggc tgcacagcgg agtgccgtct agattctcgg gttcggggtc gggaactgac     1080

tactccctta ctatttccaa cctggagcag gaggatattg ccacctactt ctgccaacaa     1140

ggaaacaccc tgccgtacac ttttggcggg ggaaccaagc tggaaatcac tggcagcaca     1200

tccggttccg ggaagcccgg ctccggagag ggcagcacca agggggaagt caagctgcag     1260

gaatcaggac ctggcctggt ggccccgagc cagtcactgt ccgtgacttg tactgtgtcc     1320

ggagtgtcgc tcccggatta cggagtgtcc tggatcaggc agccacctcg gaaaggattg     1380

gaatggctcg gagtcatctg gggttccgaa accacctatt acaactcggc actgaaatcc     1440

aggctcacca ttatcaagga taactccaag tcacaagtgt tcctgaagat gaatagcctg     1500

cagactgacg acacggcgat ctactattgc gccaagcact actactacgg cggatcctac     1560

gctatggact actggggcca ggggaccagc gtgaccgtgt catccgcggc cgcgactacc     1620

actcctgcac cacggccacc taccccagcc cccaccattg caagccagcc actttcactg     1680

cgccccgaag cgtgtagacc agctgctgga ggagccgtgc atacccgagg gctggacttc     1740

gcctgtgaca tctacatctg ggccccattg gctggaactt gcggcgtgct gctcttgtct     1800

ctggtcatta ccctgtactg ccggtcgaag aggtccagac tcttgcactc cgactacatg     1860

aacatgactc ctagaaggcc cggacccact agaaagcact accagccgta cgcccctcct     1920

cgggatttcg ccgcataccg gtccagagtg aagttcagcc gctcagccga tgcaccggcc     1980

taccagcagg gacagaacca gctctacaac gagctcaacc tgggtcggcg ggaagaatat     2040

gacgtgctgg acaaacggcg cggcagagat ccggagatgg ggggaaagcc gaggaggaag     2100

aaccctcaag agggcctgta caacgaactg cagaaggaca agatggcgga agcctactcc     2160

gagatcggca tgaagggaga acgccggaga gggaagggtc atgacggact gtaccagggc     2220

ctgtcaactg ccactaagga cacttacgat gcgctccata tgcaagcttt gcccccgcgg     2280

cgcgcgaaac gcggcagcgg cgcgaccaac tttagcctgc tgaaacaggc gggcgatgtg     2340

gaagaaaacc cgggcccgcg agcaaagagg aatattatgt tgctgctcgt gacctcgctc     2400

cttctgtgcg agctgcccca tccggctttt ctgctcatcc ctcaagtgca gctgcagcag     2460

tccggtcctg gactggtcaa gccgtcccag actctgagcc tgacttgcgc aattagcggg     2520

gactcagtct cgtccaattc ggcggcctgg aactggatcc ggcagtcacc atcaaggggc     2580

ctggaatggc tcgggcgcac ttactaccgg tccaaatggt ataccgacta cgccgtgtcc     2640

gtgaagaatc ggatcaccat taaccccgac acctcgaaga accagttctc actccaactg     2700

aacagcgtga cccccgagga taccgcggtg tactactgcg cacaagaagt ggaaccgcag     2760

gacgccttcg acatttgggg acagggaacg atggtcacag tgtcgtccgg tggaggaggt     2820

tccggaggcg gtggatctgg aggcggaggt tcggatatcc agatgaccca gagcccctcc     2880

tcggtgtccg catccgtggg cgataaggtc accattacct gtagagcgtc ccaggacgtg     2940

tccggatggc tggcctggta ccagcagaag ccaggcttgg ctcctcaact gctgatcttc     3000

ggcgccagca ctcttcaggg ggaagtgcca tcacgcttct ccggatccgg ttccggcacc     3060

gacttcaccc tgaccatcag cagcctccag cctgaggact tcgccactta ctactgccaa     3120

caggccaagt acttccccta taccttcgga agaggcacta agctggaaat caaggctagc     3180

gcaaccacta cgcctgctcc gcggcctcca acgcccgcgc ccacgatagc tagtcagccg     3240

ttgtctctcc gaccagaggc gtgtagaccg gccgctggcg gagccgtaca tactcgcgga     3300

ctcgacttcg cttgcgacat ctacatttgg gcacccttgg ctgggacctg tggggtgctg     3360

ttgctgtcct tggttattac gttgtactgc aagaggggcc ggaagaagct gctttacatc     3420

ttcaagcagc cgttcatgcg gcccgtgcag acgactcagg aagaggacgg atgctcgtgc     3480

agattccctg aggaggaaga ggggggatgc gaactgagag tcaaattttc caggtccgca     3540

gatgcccccg cgtaccagca aggccagaac caactttaca acgaactgaa cctgggtcgc     3600

cgggaggaat atgatgtgct ggataaacga agggggaggg accctgagat gggagggaaa     3660

cctcgcagga aaaacccgca ggaaggtttg tacaacgagt tgcagaagga taagatggct     3720

gaggcttact ctgaaatagg gatgaaggga gagagacgga gaggaaaagg ccatgatggc     3780

ctttaccagg gcttgagcac agcaacaaag gatacttacg acgctcttca catgcaagct     3840

ctgccaccac gg                                                         3852


<210>  56
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  56

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
        115                 120                 125             


Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
                165                 170                 175     


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
            180                 185                 190         


Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
        195                 200                 205             


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
225                 230                 235                 240 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
    290                 295                 300                 


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
305                 310                 315                 320 


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
                325                 330                 335     


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
        355                 360                 365             


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
    370                 375                 380                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr 
385                 390                 395                 400 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
                405                 410                 415     


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
            420                 425                 430         


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
        435                 440                 445             


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
    450                 455                 460                 


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
465                 470                 475                 480 


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
                485                 490                 495     


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
            500                 505                 510         


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        515                 520                 525             


Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                565                 570                 575     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            580                 585                 590         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
        595                 600                 605             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    610                 615                 620                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
625                 630                 635                 640 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
                645                 650                 655     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            660                 665                 670         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        675                 680                 685             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    690                 695                 700                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
705                 710                 715                 720 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                725                 730                 735     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            740                 745                 750         


His Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Gly Ser Gly Ala 
        755                 760                 765             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    770                 775                 780                 


Gly Pro Arg Ala Lys Arg Asn Ile Met Leu Leu Leu Val Thr Ser Leu 
785                 790                 795                 800 


Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Gln Val 
                805                 810                 815     


Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
            820                 825                 830         


Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala 
        835                 840                 845             


Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
    850                 855                 860                 


Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Thr Asp Tyr Ala Val Ser 
865                 870                 875                 880 


Val Lys Asn Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe 
                885                 890                 895     


Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
            900                 905                 910         


Cys Ala Gln Glu Val Glu Pro Gln Asp Ala Phe Asp Ile Trp Gly Gln 
        915                 920                 925             


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    930                 935                 940                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
945                 950                 955                 960 


Ser Val Ser Ala Ser Val Gly Asp Lys Val Thr Ile Thr Cys Arg Ala 
                965                 970                 975     


Ser Gln Asp Val Ser Gly Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
            980                 985                 990         


Leu Ala Pro Gln Leu Leu Ile Phe  Gly Ala Ser Thr Leu  Gln Gly Glu 
        995                 1000                 1005             


Val Pro  Ser Arg Phe Ser Gly  Ser Gly Ser Gly Thr  Asp Phe Thr 
    1010                 1015                 1020             


Leu Thr  Ile Ser Ser Leu Gln  Pro Glu Asp Phe Ala  Thr Tyr Tyr 
    1025                 1030                 1035             


Cys Gln  Gln Ala Lys Tyr Phe  Pro Tyr Thr Phe Gly  Arg Gly Thr 
    1040                 1045                 1050             


Lys Leu  Glu Ile Lys Ala Ser  Ala Thr Thr Thr Pro  Ala Pro Arg 
    1055                 1060                 1065             


Pro Pro  Thr Pro Ala Pro Thr  Ile Ala Ser Gln Pro  Leu Ser Leu 
    1070                 1075                 1080             


Arg Pro  Glu Ala Cys Arg Pro  Ala Ala Gly Gly Ala  Val His Thr 
    1085                 1090                 1095             


Arg Gly  Leu Asp Phe Ala Cys  Asp Ile Tyr Ile Trp  Ala Pro Leu 
    1100                 1105                 1110             


Ala Gly  Thr Cys Gly Val Leu  Leu Leu Ser Leu Val  Ile Thr Leu 
    1115                 1120                 1125             


Tyr Cys  Lys Arg Gly Arg Lys  Lys Leu Leu Tyr Ile  Phe Lys Gln 
    1130                 1135                 1140             


Pro Phe  Met Arg Pro Val Gln  Thr Thr Gln Glu Glu  Asp Gly Cys 
    1145                 1150                 1155             


Ser Cys  Arg Phe Pro Glu Glu  Glu Glu Gly Gly Cys  Glu Leu Arg 
    1160                 1165                 1170             


Val Lys  Phe Ser Arg Ser Ala  Asp Ala Pro Ala Tyr  Gln Gln Gly 
    1175                 1180                 1185             


Gln Asn  Gln Leu Tyr Asn Glu  Leu Asn Leu Gly Arg  Arg Glu Glu 
    1190                 1195                 1200             


Tyr Asp  Val Leu Asp Lys Arg  Arg Gly Arg Asp Pro  Glu Met Gly 
    1205                 1210                 1215             


Gly Lys  Pro Arg Arg Lys Asn  Pro Gln Glu Gly Leu  Tyr Asn Glu 
    1220                 1225                 1230             


Leu Gln  Lys Asp Lys Met Ala  Glu Ala Tyr Ser Glu  Ile Gly Met 
    1235                 1240                 1245             


Lys Gly  Glu Arg Arg Arg Gly  Lys Gly His Asp Gly  Leu Tyr Gln 
    1250                 1255                 1260             


Gly Leu  Ser Thr Ala Thr Lys  Asp Thr Tyr Asp Ala  Leu His Met 
    1265                 1270                 1275             


Gln Ala  Leu Pro Pro Arg 
    1280                 


<210>  57

<400>  57
000

<210>  58

<400>  58
000

<210>  59
<211>  3855
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  59
atgcttcttt tggtgacttc ccttttgctg tgcgagttgc cacaccccgc cttcctgctt       60

attccccagg tacagctcca gcagagtggc ccagggctcg tgaagccaag ccagacgctg      120

tccctgactt gtgcaatttc aggggattca gtttcatcaa atagcgcggc gtggaattgg      180

attcgacaat ctccttcccg agggttggaa tggcttggac gaacatatta cagatccaaa      240

tggtataacg actatgcggt atcagtaaag tcaagaataa ccattaaccc cgacacaagc      300

aagaaccaat tctctttgca gcttaactct gtcacgccag aagacacggc agtctattat      360

tgcgctcgcg aggtaacggg tgacctggaa gacgcttttg acatttgggg gcagggtacg      420

atggtgacag tcagttcagg gggcggtggg agtgggggag ggggtagcgg ggggggaggg      480

tcagacattc agatgaccca gtccccttca tccttgtctg cctccgtcgg tgacagggtg      540

acaataacat gcagagcaag ccaaacaatc tggagctatc tcaactggta ccagcagcga      600

ccaggaaaag cgccaaacct gctgatttac gctgcttcct ccctccaatc aggcgtgcct      660

agtagattta gcggtagggg ctccggcacc gattttacgc tcactataag ctctcttcaa      720

gcagaagatt ttgcgactta ttactgccag cagtcctata gtatacctca gactttcgga      780

cagggtacca agttggagat taaggcggcc gctaccacaa cccctgcgcc ccggcctcct      840

acccccgcac ccacgattgc ttctcaacct ctttcactcc gacctgaggc ttgtagacct      900

gcagccgggg gtgccgtcca cacacgggga ctcgacttcg cttgtgatat atatatttgg      960

gcgcccctgg ccggcacttg tggagttctt ttgctctctc ttgttatcac attgtactgc     1020

aagcgaggta ggaagaaatt gctttacatt tttaagcagc cgttcatgcg accagtacag     1080

actactcaag aagaagatgg gtgctcttgt cggttcccgg aagaagaaga gggtggttgc     1140

gagttgaggg tgaagttctc ccgctctgcc gacgcaccgg catatcagca gggacaaaac     1200

cagctctaca acgaattgaa cctgggtcgg cgggaagaat atgacgtgct cgataagcgg     1260

cggggtcgcg acccagaaat gggaggcaaa ccgcgcagga aaaatccaca ggagggactt     1320

tataacgaac ttcaaaagga taagatggca gaggcataca gcgaaatcgg gatgaaaggc     1380

gagagaagaa gggggaaagg gcacgatggt ctttaccagg ggctttctac cgcgacgaag     1440

gatacctacg atgctctcca tatgcaagca cttcctccta gacgggcaaa gcggggctca     1500

ggggcgacta acttttcact gttgaagcag gccggggatg tggaggagaa tcctggtcct     1560

agagctaagc gagtagacat ggccctgccc gtcactgcgc tgcttcttcc acttgcgctt     1620

ctgctgcacg cagcgcgccc ggaagtccag ctccagcaaa gcggagccga actcgtgaag     1680

ccgggggcct ccgtgaagat gagctgcaag gcatccggct acaccttcac tagctacaac     1740

atgcactggg tgaagcagac tccgggtcaa gggctggagt ggattggggc gatctacccg     1800

ggcaacggcg acacctccta caaccaaaag ttcaagggga aggctactct tacggcggac     1860

aagtcgtcca gcaccgcata catgcaactc tcctccctga cctccgagga ctcggcggac     1920

tactactgcg cccggagcaa ctactacggt tcctcctact ggttcttcga cgtgtggggt     1980

gccggaacta ctgtgactgt gtcctccggt ggtggcggat caggcggcgg gggatccggc     2040

ggtggaggat ccgacattgt gctgactcag tcccccgcaa tcctttcggc ctcccccgga     2100

gagaaggtca cgatgacttg cagggcttcg tcctccgtga actacatgga ttggtaccaa     2160

aagaagcccg ggtcgtcgcc taagccgtgg atctacgcta cctcaaacct ggcttccggc     2220

gtccctgcgc ggttcagcgg ctcggggagc ggtacctcat actcactcac catctcccgg     2280

gtggaggccg aagatgcggc cacctattat tgccaacagt ggtccttcaa tccgcccacc     2340

ttcggggggg gaaccaagct cgagatcaag gggggtggcg gctcaggggg aggcggaagc     2400

ggagggggtg gctcgggcgg cggcggttcc ggcggcggag ggtccgatat ccaaatgacc     2460

cagactacta gctcgttgag cgcctcgctc ggcgacagag tgaccattag ctgcagggca     2520

tcccaggaca tttcaaagta cctgaactgg taccaacaga agcccgacgg aactgtgaag     2580

ctcctgatct accacacctc ccggctgcac tccggagtcc cgtcgagatt ttccggctcc     2640

ggaagcggaa ccgattattc gctcaccatt tctaacctgg aacaggagga cattgccact     2700

tacttctgtc aacaaggaaa cactctgcct tacacctttg gtggcggaac caagttggaa     2760

attaccggct ccacctccgg atccggaaag cctggatccg gagagggatc aaccaaggga     2820

gaagtgaagc tgcaggagag cgggcccggc cttgtcgccc cgagccagtc cttgtccgtg     2880

acctgtactg tctccggagt cagcctgccg gactacgggg tgtcctggat ccgccagccg     2940

cctcgcaagg gcctggagtg gctcggcgtg atctggggat ccgaaacgac ttactacaac     3000

tcggccctca agtcgaggct cactattatc aaggacaact cgaagtccca ggtgttcctc     3060

aagatgaact cgctgcaaac cgacgacaca gcgatctact actgtgcaaa gcattactac     3120

tacggaggca gctacgcaat ggactactgg ggacagggaa cctccgtgac tgtctctagc     3180

gctagcgcga ccactacgcc cgccccccgc ccacctaccc ccgccccgac cattgcgagc     3240

caaccgttgt cactccgccc ggaagcctgc cgccccgccg ctggcggagc cgtgcacacc     3300

cggggactgg acttcgcatg cgacatctac atttgggccc cgctggctgg aacctgtgga     3360

gtcctgctgc tctccctcgt gatcactctg tactgccggt cgaagcgctc aagactgctg     3420

cactcagact acatgaacat gactcctcgg cggccggggc cgactcggaa gcactaccag     3480

ccttacgcac ccccgagaga tttcgcggcc taccgctccc gggtcaagtt ttcccggtct     3540

gccgacgctc cggcgtacca gcaggggcag aaccagctct acaatgagct gaatctgggt     3600

cggagagaag agtacgatgt gctggataag cggagaggca gagatccaga aatgggagga     3660

aagcctcgga gaaagaaccc acaggaggga ctgtataatg agctgcagaa ggacaaaatg     3720

gccgaagcct acagcgagat cggcatgaag ggagagcggc gcagagggaa gggacatgac     3780

ggcctgtacc agggtctgag caccgcgact aaggacacct acgatgccct tcatatgcaa     3840

gcactccctc cgcgc                                                      3855


<210>  60
<211>  1285
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  60

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp 
        115                 120                 125             


Leu Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                165                 170                 175     


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser 
            180                 185                 190         


Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu 
        195                 200                 205             


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    210                 215                 220                 


Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro 
                245                 250                 255     


Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala 
                485                 490                 495     


Lys Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
            500                 505                 510         


Asp Val Glu Glu Asn Pro Gly Pro Arg Ala Lys Arg Val Asp Met Ala 
        515                 520                 525             


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
    530                 535                 540                 


Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
545                 550                 555                 560 


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                565                 570                 575     


Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu 
            580                 585                 590         


Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn 
        595                 600                 605             


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
    610                 615                 620                 


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp 
625                 630                 635                 640 


Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe 
                645                 650                 655     


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
        675                 680                 685             


Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
    690                 695                 700                 


Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp Trp Tyr Gln 
705                 710                 715                 720 


Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
                725                 730                 735     


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            740                 745                 750         


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
        755                 760                 765             


Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gly Gly 
    770                 775                 780                 


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
785                 790                 795                 800 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                805                 810                 815     


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
            820                 825                 830         


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
        835                 840                 845             


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
    850                 855                 860                 


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
865                 870                 875                 880 


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
                885                 890                 895     


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
            900                 905                 910         


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser 
        915                 920                 925             


Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys Leu 
    930                 935                 940                 


Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val 
945                 950                 955                 960 


Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp 
                965                 970                 975     


Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
            980                 985                 990         


Gly Ser Glu Thr Thr Tyr Tyr Asn  Ser Ala Leu Lys Ser  Arg Leu Thr 
        995                 1000                 1005             


Ile Ile  Lys Asp Asn Ser Lys  Ser Gln Val Phe Leu  Lys Met Asn 
    1010                 1015                 1020             


Ser Leu  Gln Thr Asp Asp Thr  Ala Ile Tyr Tyr Cys  Ala Lys His 
    1025                 1030                 1035             


Tyr Tyr  Tyr Gly Gly Ser Tyr  Ala Met Asp Tyr Trp  Gly Gln Gly 
    1040                 1045                 1050             


Thr Ser  Val Thr Val Ser Ser  Ala Ser Ala Thr Thr  Thr Pro Ala 
    1055                 1060                 1065             


Pro Arg  Pro Pro Thr Pro Ala  Pro Thr Ile Ala Ser  Gln Pro Leu 
    1070                 1075                 1080             


Ser Leu  Arg Pro Glu Ala Cys  Arg Pro Ala Ala Gly  Gly Ala Val 
    1085                 1090                 1095             


His Thr  Arg Gly Leu Asp Phe  Ala Cys Asp Ile Tyr  Ile Trp Ala 
    1100                 1105                 1110             


Pro Leu  Ala Gly Thr Cys Gly  Val Leu Leu Leu Ser  Leu Val Ile 
    1115                 1120                 1125             


Thr Leu  Tyr Cys Arg Ser Lys  Arg Ser Arg Leu Leu  His Ser Asp 
    1130                 1135                 1140             


Tyr Met  Asn Met Thr Pro Arg  Arg Pro Gly Pro Thr  Arg Lys His 
    1145                 1150                 1155             


Tyr Gln  Pro Tyr Ala Pro Pro  Arg Asp Phe Ala Ala  Tyr Arg Ser 
    1160                 1165                 1170             


Arg Val  Lys Phe Ser Arg Ser  Ala Asp Ala Pro Ala  Tyr Gln Gln 
    1175                 1180                 1185             


Gly Gln  Asn Gln Leu Tyr Asn  Glu Leu Asn Leu Gly  Arg Arg Glu 
    1190                 1195                 1200             


Glu Tyr  Asp Val Leu Asp Lys  Arg Arg Gly Arg Asp  Pro Glu Met 
    1205                 1210                 1215             


Gly Gly  Lys Pro Arg Arg Lys  Asn Pro Gln Glu Gly  Leu Tyr Asn 
    1220                 1225                 1230             


Glu Leu  Gln Lys Asp Lys Met  Ala Glu Ala Tyr Ser  Glu Ile Gly 
    1235                 1240                 1245             


Met Lys  Gly Glu Arg Arg Arg  Gly Lys Gly His Asp  Gly Leu Tyr 
    1250                 1255                 1260             


Gln Gly  Leu Ser Thr Ala Thr  Lys Asp Thr Tyr Asp  Ala Leu His 
    1265                 1270                 1275             


Met Gln  Ala Leu Pro Pro Arg  
    1280                 1285 


<210>  61
<211>  3849
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  61
atgttgctgc tcgtgacctc gctccttctg tgcgagctgc cccatccggc ttttctgctc       60

atccctcaag tgcagctgca gcagtccggt cctggactgg tcaagccgtc ccagactctg      120

agcctgactt gcgcaattag cggggactca gtctcgtcca attcggcggc ctggaactgg      180

atccggcagt caccatcaag gggcctggaa tggctcgggc gcacttacta ccggtccaaa      240

tggtataccg actacgccgt gtccgtgaag aatcggatca ccattaaccc cgacacctcg      300

aagaaccagt tctcactcca actgaacagc gtgacccccg aggataccgc ggtgtactac      360

tgcgcacaag aagtggaacc gcaggacgcc ttcgacattt ggggacaggg aacgatggtc      420

acagtgtcgt ccggtggagg aggttccgga ggcggtggat ctggaggcgg aggttcggat      480

atccagatga cccagagccc ctcctcggtg tccgcatccg tgggcgataa ggtcaccatt      540

acctgtagag cgtcccagga cgtgtccgga tggctggcct ggtaccagca gaagccaggc      600

ttggctcctc aactgctgat cttcggcgcc agcactcttc agggggaagt gccatcacgc      660

ttctccggat ccggttccgg caccgacttc accctgacca tcagcagcct ccagcctgag      720

gacttcgcca cttactactg ccaacaggcc aagtacttcc cctatacctt cggaagaggc      780

actaagctgg aaatcaaggc ggccgctacc acaacccctg cgccccggcc tcctaccccc      840

gcacccacga ttgcttctca acctctttca ctccgacctg aggcttgtag acctgcagcc      900

gggggtgccg tccacacacg gggactcgac ttcgcttgtg atatatatat ttgggcgccc      960

ctggccggca cttgtggagt tcttttgctc tctcttgtta tcacattgta ctgcaagcga     1020

ggtaggaaga aattgcttta catttttaag cagccgttca tgcgaccagt acagactact     1080

caagaagaag atgggtgctc ttgtcggttc ccggaagaag aagagggtgg ttgcgagttg     1140

agggtgaagt tctcccgctc tgccgacgca ccggcatatc agcagggaca aaaccagctc     1200

tacaacgaat tgaacctggg tcggcgggaa gaatatgacg tgctcgataa gcggcggggt     1260

cgcgacccag aaatgggagg caaaccgcgc aggaaaaatc cacaggaggg actttataac     1320

gaacttcaaa aggataagat ggcagaggca tacagcgaaa tcgggatgaa aggcgagaga     1380

agaaggggga aagggcacga tggtctttac caggggcttt ctaccgcgac gaaggatacc     1440

tacgatgctc tccatatgca agcacttcct cctagacggg caaagcgggg ctcaggggcg     1500

actaactttt cactgttgaa gcaggccggg gatgtggagg agaatcctgg tcctagagct     1560

aagcgagtag acatggccct gcccgtcact gcgctgcttc ttccacttgc gcttctgctg     1620

cacgcagcgc gcccggaagt ccagctccag caaagcggag ccgaactcgt gaagccgggg     1680

gcctccgtga agatgagctg caaggcatcc ggctacacct tcactagcta caacatgcac     1740

tgggtgaagc agactccggg tcaagggctg gagtggattg gggcgatcta cccgggcaac     1800

ggcgacacct cctacaacca aaagttcaag gggaaggcta ctcttacggc ggacaagtcg     1860

tccagcaccg catacatgca actctcctcc ctgacctccg aggactcggc ggactactac     1920

tgcgcccgga gcaactacta cggttcctcc tactggttct tcgacgtgtg gggtgccgga     1980

actactgtga ctgtgtcctc cggtggtggc ggatcaggcg gcgggggatc cggcggtgga     2040

ggatccgaca ttgtgctgac tcagtccccc gcaatccttt cggcctcccc cggagagaag     2100

gtcacgatga cttgcagggc ttcgtcctcc gtgaactaca tggattggta ccaaaagaag     2160

cccgggtcgt cgcctaagcc gtggatctac gctacctcaa acctggcttc cggcgtccct     2220

gcgcggttca gcggctcggg gagcggtacc tcatactcac tcaccatctc ccgggtggag     2280

gccgaagatg cggccaccta ttattgccaa cagtggtcct tcaatccgcc caccttcggg     2340

gggggaacca agctcgagat caaggggggt ggcggctcag ggggaggcgg aagcggaggg     2400

ggtggctcgg gcggcggcgg ttccggcggc ggagggtccg atatccaaat gacccagact     2460

actagctcgt tgagcgcctc gctcggcgac agagtgacca ttagctgcag ggcatcccag     2520

gacatttcaa agtacctgaa ctggtaccaa cagaagcccg acggaactgt gaagctcctg     2580

atctaccaca cctcccggct gcactccgga gtcccgtcga gattttccgg ctccggaagc     2640

ggaaccgatt attcgctcac catttctaac ctggaacagg aggacattgc cacttacttc     2700

tgtcaacaag gaaacactct gccttacacc tttggtggcg gaaccaagtt ggaaattacc     2760

ggctccacct ccggatccgg aaagcctgga tccggagagg gatcaaccaa gggagaagtg     2820

aagctgcagg agagcgggcc cggccttgtc gccccgagcc agtccttgtc cgtgacctgt     2880

actgtctccg gagtcagcct gccggactac ggggtgtcct ggatccgcca gccgcctcgc     2940

aagggcctgg agtggctcgg cgtgatctgg ggatccgaaa cgacttacta caactcggcc     3000

ctcaagtcga ggctcactat tatcaaggac aactcgaagt cccaggtgtt cctcaagatg     3060

aactcgctgc aaaccgacga cacagcgatc tactactgtg caaagcatta ctactacgga     3120

ggcagctacg caatggacta ctggggacag ggaacctccg tgactgtctc tagcgctagc     3180

gcgaccacta cgcccgcccc ccgcccacct acccccgccc cgaccattgc gagccaaccg     3240

ttgtcactcc gcccggaagc ctgccgcccc gccgctggcg gagccgtgca cacccgggga     3300

ctggacttcg catgcgacat ctacatttgg gccccgctgg ctggaacctg tggagtcctg     3360

ctgctctccc tcgtgatcac tctgtactgc cggtcgaagc gctcaagact gctgcactca     3420

gactacatga acatgactcc tcggcggccg gggccgactc ggaagcacta ccagccttac     3480

gcacccccga gagatttcgc ggcctaccgc tcccgggtca agttttcccg gtctgccgac     3540

gctccggcgt accagcaggg gcagaaccag ctctacaatg agctgaatct gggtcggaga     3600

gaagagtacg atgtgctgga taagcggaga ggcagagatc cagaaatggg aggaaagcct     3660

cggagaaaga acccacagga gggactgtat aatgagctgc agaaggacaa aatggccgaa     3720

gcctacagcg agatcggcat gaagggagag cggcgcagag ggaagggaca tgacggcctg     3780

taccagggtc tgagcaccgc gactaaggac acctacgatg cccttcatat gcaagcactc     3840

cctccgcgc                                                             3849


<210>  62
<211>  1283
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  62

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Thr Asp Tyr Ala Val Ser Val Lys Asn Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro Gln 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Phe 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Arg Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg 
                485                 490                 495     


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
            500                 505                 510         


Glu Glu Asn Pro Gly Pro Arg Ala Lys Arg Val Asp Met Ala Leu Pro 
        515                 520                 525             


Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg 
    530                 535                 540                 


Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly 
545                 550                 555                 560 


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
                565                 570                 575     


Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
            580                 585                 590         


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys 
        595                 600                 605             


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
    610                 615                 620                 


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr 
625                 630                 635                 640 


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val 
                645                 650                 655     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
        675                 680                 685             


Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
    690                 695                 700                 


Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp Trp Tyr Gln Lys Lys 
705                 710                 715                 720 


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
                725                 730                 735     


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
            740                 745                 750         


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
        755                 760                 765             


Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
    770                 775                 780                 


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
785                 790                 795                 800 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                805                 810                 815     


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
            820                 825                 830         


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
        835                 840                 845             


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
    850                 855                 860                 


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
865                 870                 875                 880 


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
                885                 890                 895     


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
            900                 905                 910         


Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys 
        915                 920                 925             


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu 
    930                 935                 940                 


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
945                 950                 955                 960 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
                965                 970                 975     


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
            980                 985                 990         


Glu Thr Thr Tyr Tyr Asn Ser Ala  Leu Lys Ser Arg Leu  Thr Ile Ile 
        995                 1000                 1005             


Lys Asp  Asn Ser Lys Ser Gln  Val Phe Leu Lys Met  Asn Ser Leu 
    1010                 1015                 1020             


Gln Thr  Asp Asp Thr Ala Ile  Tyr Tyr Cys Ala Lys  His Tyr Tyr 
    1025                 1030                 1035             


Tyr Gly  Gly Ser Tyr Ala Met  Asp Tyr Trp Gly Gln  Gly Thr Ser 
    1040                 1045                 1050             


Val Thr  Val Ser Ser Ala Ser  Ala Thr Thr Thr Pro  Ala Pro Arg 
    1055                 1060                 1065             


Pro Pro  Thr Pro Ala Pro Thr  Ile Ala Ser Gln Pro  Leu Ser Leu 
    1070                 1075                 1080             


Arg Pro  Glu Ala Cys Arg Pro  Ala Ala Gly Gly Ala  Val His Thr 
    1085                 1090                 1095             


Arg Gly  Leu Asp Phe Ala Cys  Asp Ile Tyr Ile Trp  Ala Pro Leu 
    1100                 1105                 1110             


Ala Gly  Thr Cys Gly Val Leu  Leu Leu Ser Leu Val  Ile Thr Leu 
    1115                 1120                 1125             


Tyr Cys  Arg Ser Lys Arg Ser  Arg Leu Leu His Ser  Asp Tyr Met 
    1130                 1135                 1140             


Asn Met  Thr Pro Arg Arg Pro  Gly Pro Thr Arg Lys  His Tyr Gln 
    1145                 1150                 1155             


Pro Tyr  Ala Pro Pro Arg Asp  Phe Ala Ala Tyr Arg  Ser Arg Val 
    1160                 1165                 1170             


Lys Phe  Ser Arg Ser Ala Asp  Ala Pro Ala Tyr Gln  Gln Gly Gln 
    1175                 1180                 1185             


Asn Gln  Leu Tyr Asn Glu Leu  Asn Leu Gly Arg Arg  Glu Glu Tyr 
    1190                 1195                 1200             


Asp Val  Leu Asp Lys Arg Arg  Gly Arg Asp Pro Glu  Met Gly Gly 
    1205                 1210                 1215             


Lys Pro  Arg Arg Lys Asn Pro  Gln Glu Gly Leu Tyr  Asn Glu Leu 
    1220                 1225                 1230             


Gln Lys  Asp Lys Met Ala Glu  Ala Tyr Ser Glu Ile  Gly Met Lys 
    1235                 1240                 1245             


Gly Glu  Arg Arg Arg Gly Lys  Gly His Asp Gly Leu  Tyr Gln Gly 
    1250                 1255                 1260             


Leu Ser  Thr Ala Thr Lys Asp  Thr Tyr Asp Ala Leu  His Met Gln 
    1265                 1270                 1275             


Ala Leu  Pro Pro Arg 
    1280             


<210>  63

<400>  63
000

<210>  64

<400>  64
000

<210>  65
<211>  1476
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  65
atgcttcttt tggtgacttc ccttttgctg tgcgagttgc cacaccccgc cttcctgctt       60

attccccagg tacagcttca acagagtggg ccgggactgg tgaaacactc ccaaacactt      120

tctctgacgt gcgctatatc aggtgactct gtttcatcta attctgctgc gtggaactgg      180

attcgacaat ctcccagtcg cgggttggaa tggctgggac gaacatatta tcggtctaag      240

tggtataacg attatgctgt atctgttaaa tctcgaatta cgattaatcc tgacacctcc      300

aagaaccagt tctccctcca gttgaactca gtcacaccgg aagacactgc ggtctactat      360

tgcgctcaag aagtcgagcc acatgatgca ttcgacatct ggggccaggg aacgatggtc      420

accgtcagca gtggcggcgg cggatctggg ggtggcggtt ctggcggtgg aggatcagac      480

atacaaatga cgcagagtcc ctcaagtgtg tacgcgagtg tgggggataa ggtaactatt      540

acgtgcagag cgtcacagga tgttagtgga tggcttgcct ggtatcagca gaagccaggc      600

cttgctccac agctccttat cagtggtgct tctacacttc agggcgaggt tccgagtaga      660

ttctctggtt ctggatctgg tactgacttc actcttacaa tttcttcttt gcaaccagaa      720

gactttgcga cttattactg ccaacaggcc aaatacttcc cttatacatt tggccaaggt      780

accaagttgg agataaaggc ggccgcaact accacccctg cccctcggcc gccgactccg      840

gccccaacca tcgcaagcca acccctctcc ttgcgccccg aagcttgccg cccggccgcg      900

ggtggagccg tgcatacccg ggggctggac tttgcctgcg atatctacat ttgggccccg      960

ctggccggca cttgcggcgt gctcctgctg tcgctggtca tcacccttta ctgcaagagg     1020

ggccggaaga agctgcttta catcttcaag cagccgttca tgcggcccgt gcagacgact     1080

caggaagagg acggatgctc gtgcagattc cctgaggagg aagagggggg atgcgaactg     1140

cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc     1200

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga     1260

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac     1320

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg     1380

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc     1440

tacgatgcct tgcatatgca agcactccca ccccgg                               1476


<210>  66
<211>  492
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  66

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys His Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro His 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Ser 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  67
<211>  1476
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  67
atgttgctgc tcgtgacctc gctccttctg tgcgagctgc cccatccggc ttttctgctc       60

atccctcaag tgcagctgca gcagtccggt cctggactgg tcaagccgtc ccagactctg      120

agcctgactt gcgcaattag cggggactca gtctcgtcca attcggcggc ctggaactgg      180

atccggcagt caccatcaag gggcctggaa tggctcgggc gcacttacta ccggtccaaa      240

tggtataccg actacgccgt gtccgtgaag aatcggatca ccattaaccc cgacacctcg      300

aagaaccagt tctcactcca actgaacagc gtgacccccg aggataccgc ggtgtactac      360

tgcgcacaag aagtggaacc gcaggacgcc ttcgacattt ggggacaggg aacgatggtc      420

acagtgtcgt ccggtggagg aggttccgga ggcggtggat ctggaggcgg aggttcggat      480

atccagatga cccagagccc ctcctcggtg tccgcatccg tgggcgataa ggtcaccatt      540

acctgtagag cgtcccagga cgtgtccgga tggctggcct ggtaccagca gaagccaggc      600

ttggctcctc aactgctgat cttcggcgcc agcactcttc agggggaagt gccatcacgc      660

ttctccggat ccggttccgg caccgacttc accctgacca tcagcagcct ccagcctgag      720

gacttcgcca cttactactg ccaacaggcc aagtacttcc cctatacctt cggaagaggc      780

actaagctgg aaatcaaggc ggccgcaact accacccctg cccctcggcc gccgactccg      840

gccccaacca tcgcaagcca acccctctcc ttgcgccccg aagcttgccg cccggccgcg      900

ggtggagccg tgcatacccg ggggctggac tttgcctgcg atatctacat ttgggccccg      960

ctggccggca cttgcggcgt gctcctgctg tcgctggtca tcacccttta ctgcaagagg     1020

ggccggaaga agctgcttta catcttcaag cagccgttca tgcggcccgt gcagacgact     1080

caggaagagg acggatgctc gtgcagattc cctgaggagg aagagggggg atgcgaactg     1140

cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc     1200

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga     1260

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac     1320

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg     1380

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc     1440

tacgatgcct tgcatatgca agcactccca ccccgg                               1476


<210>  68
<211>  492
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  68

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Thr Asp Tyr Ala Val Ser Val Lys Asn Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro Gln 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Phe 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Arg Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  69
<211>  1476
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  69
atgttgctgc tcgtgacctc gctccttctg tgcgagctgc cccatccggc ttttctgctc       60

atccctcaag tgcagctgca gcagtccggt cctggactgg tcaagccgtc ccagactctg      120

agcctgactt gcgccattag cgggaactca gtctcgtcca attcggcggc ctggaactgg      180

atccggcagt caccatcaag gggcctggaa tggctcgggc gcacttacta ccggtccaaa      240

tggtataacg actacgccgt gtccgtgaag tcccggatca ccattaaccc cgacacctcg      300

aagaaccagt tctcactcca actgaacagc gtgacccccg aggataccgc ggtgtactac      360

tgcgcacaag aagtggaacc gcaggacgcc ttcgacattt ggggacaggg aacgatggtc      420

acagtgtcgt ccggtggagg aggttccgga ggcggtggat ctggaggcgg aggttcggat      480

atccagatga cccagagccc ctcctcggtg tccgcatccg tgggcgataa ggtcaccatt      540

acctgtagag cgtcccagga cgtgtccgga tggctggcct ggtaccagca gaagccaggc      600

ttggctcctc aactgctgat ctttggcgcc agcactcttc agggggaggt gccatcacgc      660

ttctccggag gtggttccgg caccgacttc accctgacca tcagcagcct ccagcctgag      720

gacttcgcca cttactactg ccaacaggcc aagtacttcc cctatacctt cggacaaggc      780

actaagctgg aaatcaaggc ggccgcaact accacccctg cccctcggcc gccgactccg      840

gccccaacca tcgcaagcca acccctctcc ttgcgccccg aagcttgccg cccggccgcg      900

ggtggagccg tgcatacccg ggggctggac tttgcctgcg atatctacat ttgggccccg      960

ctggccggca cttgcggcgt gctcctgctg tcgctggtca tcacccttta ctgcaagagg     1020

ggccggaaga agctgcttta catcttcaag cagccgttca tgcggcccgt gcagacgact     1080

caggaagagg acggatgctc gtgcagattc cctgaggagg aagagggggg atgcgaactg     1140

cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc     1200

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga     1260

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac     1320

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg     1380

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc     1440

tacgatgcct tgcatatgca agcactccca ccccgg                               1476


<210>  70
<211>  492
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  70

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asn Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln Glu Val Glu Pro Gln 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile Phe 
        195                 200                 205             


Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly Gly 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  71

<400>  71
000

<210>  72

<400>  72
000

<210>  73
<211>  2280
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  73
atgctccttc tcgtgacctc cctgcttctc tgcgaactgc cccatcctgc cttcctgctg       60

attcccgagg tgcagttgca acagtcagga gctgaactgg tcaagccagg agccagcgtg      120

aagatgagct gcaaggcctc cggttacacc ttcacctcct acaacatgca ctgggtgaaa      180

cagaccccgg gacaagggct cgaatggatt ggcgccatct accccgggaa tggcgatact      240

tcgtacaacc agaagttcaa gggaaaggcc accctgaccg ccgacaagag ctcctccacc      300

gcgtatatgc agttgagctc cctgacctcc gaggactccg ccgactacta ctgcgcacgg      360

tccaactact atggaagctc gtactggttc ttcgatgtct ggggggccgg caccactgtg      420

accgtcagct ccgggggcgg aggatccggt ggaggcggaa gcgggggtgg aggatccgac      480

attgtgctga ctcagtcccc ggcaatcctg tcggcctcac cgggcgaaaa ggtcacgatg      540

acttgtagag cgtcgtccag cgtgaactac atggattggt accaaaagaa gcctggatcg      600

tcacccaagc cttggatcta cgctacatct aacctggcct ccggcgtgcc agcgcggttc      660

agcgggtccg gctcgggcac ctcatactcg ctgaccatct cccgcgtgga ggctgaggac      720

gccgcgacct actactgcca gcagtggtcc ttcaacccgc cgacttttgg aggcggtact      780

aagctggaga tcaaaggagg cggcggcagc ggcgggggag ggtccggagg gggtggttct      840

ggtggaggag gatcgggagg cggtggcagc gacattcaga tgactcagac cacctcctcc      900

ctgtccgcct ccctgggcga ccgcgtgacc atctcatgcc gcgccagcca ggacatctcg      960

aagtacctca actggtacca gcagaagccc gacggaaccg tgaagctcct gatctaccac     1020

acctcccggc tgcacagcgg agtgccgtct agattctcgg gttcggggtc gggaactgac     1080

tactccctta ctatttccaa cctggagcag gaggatattg ccacctactt ctgccaacaa     1140

ggaaacaccc tgccgtacac ttttggcggg ggaaccaagc tggaaatcac tggcagcaca     1200

tccggttccg ggaagcccgg ctccggagag ggcagcacca agggggaagt caagctgcag     1260

gaatcaggac ctggcctggt ggccccgagc cagtcactgt ccgtgacttg tactgtgtcc     1320

ggagtgtcgc tcccggatta cggagtgtcc tggatcaggc agccacctcg gaaaggattg     1380

gaatggctcg gagtcatctg gggttccgaa accacctatt acaactcggc actgaaatcc     1440

aggctcacca ttatcaagga taactccaag tcacaagtgt tcctgaagat gaatagcctg     1500

cagactgacg acacggcgat ctactattgc gccaagcact actactacgg cggatcctac     1560

gctatggact actggggcca ggggaccagc gtgaccgtgt catccgcggc cgcgactacc     1620

actcctgcac cacggccacc taccccagcc cccaccattg caagccagcc actttcactg     1680

cgccccgaag cgtgtagacc agctgctgga ggagccgtgc atacccgagg gctggacttc     1740

gcctgtgaca tctacatctg ggccccattg gctggaactt gcggcgtgct gctcttgtct     1800

ctggtcatta ccctgtactg ccggtcgaag aggtccagac tcttgcactc cgactacatg     1860

aacatgactc ctagaaggcc cggacccact agaaagcact accagccgta cgcccctcct     1920

cgggatttcg ccgcataccg gtccagagtg aagttcagcc gctcagccga tgcaccggcc     1980

taccagcagg gacagaacca gctctacaac gagctcaacc tgggtcggcg ggaagaatat     2040

gacgtgctgg acaaacggcg cggcagagat ccggagatgg ggggaaagcc gaggaggaag     2100

aaccctcaag agggcctgta caacgaactg cagaaggaca agatggcgga agcctactcc     2160

gagatcggca tgaagggaga acgccggaga gggaagggtc atgacggact gtaccagggc     2220

ctgtcaactg ccactaagga cacttacgat gcgctccata tgcaagcttt gcccccgcgg     2280


<210>  74
<211>  760
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  74

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
        115                 120                 125             


Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
                165                 170                 175     


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
            180                 185                 190         


Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
        195                 200                 205             


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
225                 230                 235                 240 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
    290                 295                 300                 


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
305                 310                 315                 320 


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
                325                 330                 335     


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
        355                 360                 365             


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
    370                 375                 380                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr 
385                 390                 395                 400 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
                405                 410                 415     


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
            420                 425                 430         


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
        435                 440                 445             


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
    450                 455                 460                 


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
465                 470                 475                 480 


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
                485                 490                 495     


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
            500                 505                 510         


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        515                 520                 525             


Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                565                 570                 575     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            580                 585                 590         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
        595                 600                 605             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    610                 615                 620                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
625                 630                 635                 640 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
                645                 650                 655     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            660                 665                 670         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        675                 680                 685             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    690                 695                 700                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
705                 710                 715                 720 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                725                 730                 735     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            740                 745                 750         


His Met Gln Ala Leu Pro Pro Arg 
        755                 760 


<210>  75
<211>  1482
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  75
atgcttcttt tggtgacttc ccttttgctg tgcgagttgc cacaccccgc cttcctgctt       60

attccccagg tacagctcca gcagagtggc ccagggctcg tgaagccaag ccagacgctg      120

tccctgactt gtgcaatttc aggggattca gtttcatcaa atagcgcggc gtggaattgg      180

attcgacaat ctccttcccg agggttggaa tggcttggac gaacatatta cagatccaaa      240

tggtataacg actatgcggt atcagtaaag tcaagaataa ccattaaccc cgacacaagc      300

aagaaccaat tctctttgca gcttaactct gtcacgccag aagacacggc agtctattat      360

tgcgctcgcg aggtaacggg tgacctggaa gacgcttttg acatttgggg gcagggtacg      420

atggtgacag tcagttcagg gggcggtggg agtgggggag ggggtagcgg ggggggaggg      480

tcagacattc agatgaccca gtccccttca tccttgtctg cctccgtcgg tgacagggtg      540

acaataacat gcagagcaag ccaaacaatc tggagctatc tcaactggta ccagcagcga      600

ccaggaaaag cgccaaacct gctgatttac gctgcttcct ccctccaatc aggcgtgcct      660

agtagattta gcggtagggg ctccggcacc gattttacgc tcactataag ctctcttcaa      720

gcagaagatt ttgcgactta ttactgccag cagtcctata gtatacctca gactttcgga      780

cagggtacca agttggagat taaggcggcc gcaactacca cccctgcccc tcggccgccg      840

actccggccc caaccatcgc aagccaaccc ctctccttgc gccccgaagc ttgccgcccg      900

gccgcgggtg gagccgtgca tacccggggg ctggactttg cctgcgatat ctacatttgg      960

gccccgctgg ccggcacttg cggcgtgctc ctgctgtcgc tggtcatcac cctttactgc     1020

aagaggggcc ggaagaagct gctttacatc ttcaagcagc cgttcatgcg gcccgtgcag     1080

acgactcagg aagaggacgg atgctcgtgc agattccctg aggaggaaga ggggggatgc     1140

gaactgcgcg tcaagttctc acggtccgcc gacgcccccg catatcaaca gggccagaat     1200

cagctctaca acgagctgaa cctgggaagg agagaggagt acgacgtgct ggacaagcga     1260

cgcggacgcg acccggagat gggggggaaa ccacggcgga aaaaccctca ggaaggactg     1320

tacaacgaac tccagaaaga caagatggcg gaagcctact cagaaatcgg gatgaaggga     1380

gagcggagga ggggaaaggg tcacgacggg ctgtaccagg gactgagcac cgccactaag     1440

gatacctacg atgccttgca tatgcaagca ctcccacccc gg                        1482


<210>  76
<211>  494
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  76

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp 
        115                 120                 125             


Leu Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                165                 170                 175     


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser 
            180                 185                 190         


Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu 
        195                 200                 205             


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    210                 215                 220                 


Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro 
                245                 250                 255     


Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  77
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  GMCSF leader peptide

<400>  77
atgcttcttt tggtgacttc ccttttgctg tgcgagttgc cacaccccgc cttcctgctt       60

attccc                                                                  66


<210>  78
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  GMCSF leader peptide

<400>  78

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  79
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  CD8a leader peptide

<400>  79
atggccctgc ccgtcactgc gctgcttctt ccacttgcgc ttctgctgca cgcagcgcgc       60

ccg                                                                     63


<210>  80
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  CD8a leader peptide

<400>  80

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  81
<211>  216
<212>  DNA
<213>  Artificial

<220>
<223>  CD8 hinge and transmembrane domain

<400>  81
gcggccgcta ccacaacccc tgcgccccgg cctcctaccc ccgcacccac gattgcttct       60

caacctcttt cactccgacc tgaggcttgt agacctgcag ccgggggtgc cgtccacaca      120

cggggactcg acttcgcttg tgatatatat atttgggcgc ccctggccgg cacttgtgga      180

gttcttttgc tctctcttgt tatcacattg tactgc                                216


<210>  82
<211>  72
<212>  PRT
<213>  Artificial

<220>
<223>  CD8 hinge and transmembrane domain

<400>  82

Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys 
65                  70          


<210>  83
<211>  126
<212>  DNA
<213>  Artificial

<220>
<223>  4-1BB/CD137 costimulatory domain

<400>  83
aagcgaggta ggaagaaatt gctttacatt tttaagcagc cgttcatgcg accagtacag       60

actactcaag aagaagatgg gtgctcttgt cggttcccgg aagaagaaga gggtggttgc      120

gagttg                                                                 126


<210>  84
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  4-1BB/CD137 costimulatory domain

<400>  84

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  85
<211>  123
<212>  DNA
<213>  Artificial

<220>
<223>  CD28 costimulatory domain

<400>  85
cggtcgaagc gctcaagact gctgcactca gactacatga acatgactcc tcggcggccg       60

gggccgactc ggaagcacta ccagccttac gcacccccga gagatttcgc ggcctaccgc      120

tcc                                                                    123


<210>  86
<211>  41
<212>  PRT
<213>  Artificial

<220>
<223>  CD28 costimulatory domain

<400>  86

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  87
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  87
agggtgaagt tctcccgctc tgccgacgca ccggcatatc agcagggaca aaaccagctc       60

tacaacgaat tgaacctggg tcggcgggaa gaatatgacg tgctcgataa gcggcggggt      120

cgcgacccag aaatgggagg caaaccgcgc aggaaaaatc cacaggaggg actttataac      180

gaacttcaaa aggataagat ggcagaggca tacagcgaaa tcgggatgaa aggcgagaga      240

agaaggggga aagggcacga tggtctttac caggggcttt ctaccgcgac gaaggatacc      300

tacgatgctc tccatatgca agcacttcct cctaga                                336


<210>  88
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  88

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  89
<211>  91
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  89
cgggcaaagc ggggctcagg ggcgactaac ttttcactgt tgaagcaggc cggggatgtg       60

gaggagaatc ctggtcctag agctaagcga g                                      91


<210>  90
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  90

Arg Ala Lys Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
1               5                   10                  15      


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Ala Lys Arg 
            20                  25                  30  


<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  95
caggtacagc ttcaacagag tgggccggga ctggtgaaac actcccaaac actttctctg       60

acgtgcgcta tatcaggtga ctctgtttca tctaattctg ctgcgtggaa ctggattcga      120

caatctccca gtcgcgggtt ggaatggctg ggacgaacat attatcggtc taagtggtat      180

aacgattatg ctgtatctgt taaatctcga attacgatta atcctgacac ctccaagaac      240

cagttctccc tccagttgaa ctcagtcaca ccggaagaca ctgcggtcta ctattgcgct      300

caagaagtcg agccacatga tgcattcgac atctggggcc agggaacgat ggtcaccgtc      360

agcagt                                                                 366


<210>  96
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  96

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys His Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Gln Glu Val Glu Pro His Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  97
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  97
gacatacaaa tgacgcagag tccctcaagt gtgtacgcga gtgtggggga taaggtaact       60

attacgtgca gagcgtcaca ggatgttagt ggatggcttg cctggtatca gcagaagcca      120

ggccttgctc cacagctcct tatcagtggt gcttctacac ttcagggcga ggttccgagt      180

agattctctg gttctggatc tggtactgac ttcactctta caatttcttc tttgcaacca      240

gaagactttg cgacttatta ctgccaacag gccaaatact tcccttatac atttggccaa      300

ggtaccaagt tggagataaa g                                                321


<210>  98
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  99
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  99
caagtgcagc tgcagcagtc cggtcctgga ctggtcaagc cgtcccagac tctgagcctg       60

acttgcgcaa ttagcgggga ctcagtctcg tccaattcgg cggcctggaa ctggatccgg      120

cagtcaccat caaggggcct ggaatggctc gggcgcactt actaccggtc caaatggtat      180

accgactacg ccgtgtccgt gaagaatcgg atcaccatta accccgacac ctcgaagaac      240

cagttctcac tccaactgaa cagcgtgacc cccgaggata ccgcggtgta ctactgcgca      300

caagaagtgg aaccgcagga cgccttcgac atttggggac agggaacgat ggtcacagtg      360

tcgtcc                                                                 366


<210>  100
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  100

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Thr Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Asn Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Gln Glu Val Glu Pro Gln Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  101
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  101
gatatccaga tgacccagag cccctcctcg gtgtccgcat ccgtgggcga taaggtcacc       60

attacctgta gagcgtccca ggacgtgtcc ggatggctgg cctggtacca gcagaagcca      120

ggcttggctc ctcaactgct gatcttcggc gccagcactc ttcaggggga agtgccatca      180

cgcttctccg gatccggttc cggcaccgac ttcaccctga ccatcagcag cctccagcct      240

gaggacttcg ccacttacta ctgccaacag gccaagtact tcccctatac cttcggaaga      300

ggcactaagc tggaaatcaa g                                                321


<210>  102
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Arg Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  103
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  103
caagtgcagc tgcagcagtc cggtcctgga ctggtcaagc cgtcccagac tctgagcctg       60

acttgcgcca ttagcgggaa ctcagtctcg tccaattcgg cggcctggaa ctggatccgg      120

cagtcaccat caaggggcct ggaatggctc gggcgcactt actaccggtc caaatggtat      180

aacgactacg ccgtgtccgt gaagtcccgg atcaccatta accccgacac ctcgaagaac      240

cagttctcac tccaactgaa cagcgtgacc cccgaggata ccgcggtgta ctactgcgca      300

caagaagtgg aaccgcagga cgccttcgac atttggggac agggaacgat ggtcacagtg      360

tcgtcc                                                                 366


<210>  104
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  104

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asn Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Gln Glu Val Glu Pro Gln Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  105
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  105
gatatccaga tgacccagag cccctcctcg gtgtccgcat ccgtgggcga taaggtcacc       60

attacctgta gagcgtccca ggacgtgtcc ggatggctgg cctggtacca gcagaagcca      120

ggcttggctc ctcaactgct gatctttggc gccagcactc ttcaggggga ggtgccatca      180

cgcttctccg gaggtggttc cggcaccgac ttcaccctga ccatcagcag cctccagcct      240

gaggacttcg ccacttacta ctgccaacag gccaagtact tcccctatac cttcggacaa      300

ggcactaagc tggaaatcaa g                                                321


<210>  106
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Leu Gln Gly Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Tyr Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  107
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Whitlow linker amino acid sequence

<400>  107

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  108
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible interchain linker amino acid sequence

<400>  108

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


