                               SEQUENCE LISTING

<110> THE JOHNS HOPKINS UNIVERSITY
 
<120> METHODS OF TREATING OR PREVENTING CONDITIONS OF DENDRITIC AND 
      NEURAL SPINE DEFECTS

<130> P14974-02

<140>
<141>

<150> 62/732,628
<151> 2018-09-18

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 133
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210> 2
<211> 2058
<212> DNA
<213> Homo sapiens

<400> 2
aagatgctcc gtggaaggga gccgagcggt gggcagaggc tgagtccccg ataacgagcg       60

cctcacattt ccgtggcatt cccatttgct agtgcgctgc tgcggccgca cgcctgattg      120

atatatgact gcaatggcac ttttccattt gacattctct ctctctctct ccctctctct      180

ctctccctct ctctctccct ctctctctct ccctgtgtcg cttaaacaac agtcctaact      240

tttgtgtgtt gcaaatataa aaggcaagcc atgtgacaga gggacagaag aacaaaagca      300

tttggaagta acaggacctc tttctagctc tcagaaaagt ctgagaagaa aggagccctg      360

cgttccccta agctgtgcag cagatactgt gatgatggat tgcaagtgca aagagtaaga      420

caaaactcca gcacataaag gacaatgaca accagaaagc ttcagcccga tcctgccctt      480

tccttgaacg ggactggatc ctaggaggtg aagccatttc caattttttg tcctctgcct      540

ccctctgctg ttcttctaga gaagtttttc cttacaacaa tgagaaaaca tgtactagct      600

gcatcctttt ctatgctctc cctgctggtg ataatgggag atacagacag taaaacggac      660

agctcattca taatggactc ggaccctcga cgctgcatga ggcaccacta tgtggattct      720

atcagtcacc cattgtacaa gtgtagctca aagatggtgc tcctggccag gtgcgagggg      780

cactgcagcc aggcgtcacg ctccgagcct ttggtgtcgt tcagcactgt cctcaagcaa      840

cccttccgtt cctcctgtca ctgctgccgg ccccagactt ccaagctgaa ggcactgcgg      900

ctgcgatgct cagggggcat gcgactcact gccacctacc ggtacatcct ctcctgtcac      960

tgcgaggaat gcaattcctg aggcccgctg ctgtgtgtgg cttctggatg ggacaactgt     1020

agaggcagtt cgaccagcca gggaaagact ggcaagaaaa gagttaaggc aaaaaaggat     1080

gcaacaattc tcccgggact ctgcatattc tagtaataaa gactctacat gcttgttgac     1140

agagagagat actctgggaa cttctttgca gttcccatct cctttctctg gtacaatttc     1200

ttttggttca ttttcagatt caggcatttt cccccttggc tctcaatgct gtttgggttt     1260

ccaacaattc agcattagtg ggaaaaagtg ggccctcata cacaagcgtg tcaggctgtc     1320

agtgtttggt gcacgctggg gaagaattta ctttggaaag tagaaaagcc cagcttttcc     1380

tgggacatct tctgttattg ttgatgtttt tttttacctt gtcattttgg tctaaggttg     1440

ccattgctgc taaaggttac cgatttcaaa gtccagatac caagcatgtg gatatgttta     1500

gctacgttta ctcacagcca gcgaactgac attaaaataa ctaacaaaca gattctttta     1560

tgtgatgctg gaactcttga cagctataat tattattcag aaatgacttt ttgaaagtaa     1620

aagcagcata aagaatttgt cacaggaagg ctgtctcaga taaattatgg taaaattttg     1680

taagggagca gacttttaaa gacttgcaca aatacggatc ctgcactgac tctggaaaag     1740

gcatatatgt actagtggca tggagaatgc accatactca tgcatgcaaa ttagacaacc     1800

aagtatgaat ctatttgtgg gtgtgctata gctttagccg tgtcacgggc atcattctct     1860

aatatccact tgtccatgtg aaacatgttg ccaaaatggt ggcctggctt gtcttctgaa     1920

cgtttggttc aaatgtgttt tggtcctgga ggctcaaatt ttgagttatt cccacgtttt     1980

gaaataaaaa gagtatattc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2040

aaaaaaaaaa aaaaaaaa                                                   2058


<210> 3
<211> 1962
<212> DNA
<213> Mus musculus

<400> 3
ctcatcttaa gatgctccat ggaaaagatc cgagcagtgg gcagaggctg tgagtccccg       60

ataacgagag cgcctaacat ttccgtggta ttcccatttg ctagagcgct gctgcggcca      120

cacgcctgat tgatatatgc ctgcaatggc acttttccat ttgacactct ccctctctct      180

ctccctctct ctccctctct ctctctccct ctctctccct ctctctccct gggtcgctta      240

aacaacagtc ctaacttttg tgtgttgcaa atataaaagg caagccatgt gacagaggga      300

cagaagaaca aaagcatttg gaagtaacag gacctctttc tagctctcag aaaagtctga      360

gaagaaagga gccctgcgtt tcccccaagc tgtgcagcac atactgctgt gatcggttgc      420

aagtgaaaga agcaagagaa attcctgcat acaaaggaca atgacaacca gaaagcggca      480

gccctatcct gctctggcct tgaaagggac tggatcctag gaggtggcag catttccaat      540

ctattgtcct ctgtctccct ctgctgtttt tctggaggag tttcccttta caacaatgag      600

aaatcatgta ctagctgcat ccatttctat gctctccctg ctggccataa tgggagatac      660

agacagcaaa acagacagtt catttctgat ggactctcaa cgctgcatga gacaccatta      720

tgtcgattct atcagtcacc cactgtacaa atgtagctca aagatggtgc tcctggccag      780

atgtgagggg cactgcagcc aggcatcacg ctctgagccc ttggtgtcct tcagcactgt      840

cctcaagcaa cctttccgtt cctcctgtca ctgctgccga ccccagactt ccaagctgaa      900

ggctctgcgt ctgcgctgct cagggggcat gcgacttact gccacttacc ggtacatcct      960

ctcctgtcac tgtgaggaat gcagctcctg agacttgctg atgattggct ttctgactgg     1020

cacaaccaca ggagcagttc aacctgccag agacggactg gcaagaaaag agttaaggca     1080

gataaagatg gagcaagtcc cataggattt tgcatattct tgtcctaaag actcaatgtg     1140

cttttgacag aaagtgactc tgggaacttg cttttcattc ccatctcctt tccctggaag     1200

aatttctttt ggttacttta cagattcagg catttcccct gttggctcta attgtggttt     1260

gggtgcctga cagctctgca ttagtgggaa aatgtggggc cctgtgcaat agcatgtcag     1320

gctgttccta tttggtgcat attagggaaa attttaccta actctcctta ggagatcttt     1380

gcttgttgtt tcccctggtc attttggtct aagatttgcc tctaaagttt cctggtttca     1440

agatctggac acccagtcca tggatgttta gtgaggctta ctcacagcca gctaactgct     1500

actaaaataa ctaacacatg ggttctttta tgtgacagcg ggactcctga ccactatagt     1560

aattattcag aagtgactga ggggatataa atgtggcaga ggaatttata atctgaagcc     1620

ttttgtgagg aagcaggctt tcacacatac acactcaggt ggatcctgca ctgactctgg     1680

agaaggcata cattatactt ggtgtggaga acacaccata ctcataattg agcattagtc     1740

aagcatgtag gaatctactt gtgggtgtgc aatagcttca gccatatctt agctatatcc     1800

acctgtctat gtgaagcttg ttgccgtagt ggtggcccga cttattgtct gaaatttttg     1860

tttcaatata tttttggtcc tcgaagctca aattttgaag tctccccatg ttttcaaata     1920

aaaatagagt accttcaaaa aaaaaaaaaa aaaaaaaaaa aa                        1962


<210> 4
<211> 131
<212> PRT
<213> Mus musculus

<400> 4
Met Arg Asn His Val Leu Ala Ala Ser Ile Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Ala Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Leu Met 
            20                  25                  30          


Asp Ser Gln Arg Cys Met Arg His His Tyr Val Asp Ser Ile Ser His 
        35                  40                  45              


Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg Cys Glu 
    50                  55                  60                  


Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser Phe Ser 
65                  70                  75                  80  


Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys Arg Pro 
                85                  90                  95      


Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly Gly Met 
            100                 105                 110         


Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys Glu Glu 
        115                 120                 125             


Cys Ser Ser 
    130     


<210> 5
<211> 1076
<212> DNA
<213> Mus musculus


<220>
<221> CDS
<222> (140)..(532)

<220>
<221> modified_base
<222> (887)..(887)
<223> a, c, t, g, unknown or other

<400> 5
agcaagcaca ggtggcagcg gctgcagggg cgcatcgccg gcgtgcgccc tcctgcagcc       60

ctgggcgcat cgctctctcg gggaagccac cctcggagcc cccggagctc cccgccaagc      120

gccataagct tcgatcgcc atg aga aat cat gta cta gct gca tcc att tct       172
                     Met Arg Asn His Val Leu Ala Ala Ser Ile Ser          
                     1               5                   10               

atg ctc tcc ctg ctg gcc ata atg gga gat aca gac agc aaa aca gac        220
Met Leu Ser Leu Leu Ala Ile Met Gly Asp Thr Asp Ser Lys Thr Asp           
            15                  20                  25                    

agt tca ttt ctg atg gac tct caa cgc tgc atg aga cac cat tat gtc        268
Ser Ser Phe Leu Met Asp Ser Gln Arg Cys Met Arg His His Tyr Val           
        30                  35                  40                        

gat tct atc agt cac cca ctg tac aaa tgt agc tca aag atg gtg ctc        316
Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu           
    45                  50                  55                            

ctg gcc aga tgt gag ggg cac tgc agc cag gca tca cgc tct gag ccc        364
Leu Ala Arg Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro           
60                  65                  70                  75            

ttg gtg tcc ttc agc act gtc ctc aag caa cct ttc cgt tcc tcc tgt        412
Leu Val Ser Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys           
                80                  85                  90                

cac tgc tgc cga ccc cag act tcc aag ctg aag gct ctg cgt ctg cgc        460
His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg           
            95                  100                 105                   

tgc tca ggg ggc atg cga ctt act gcc act tac cgg tac atc ctc tcc        508
Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser           
        110                 115                 120                       

tgt cac tgt gag gaa tgc agc tcc tgaacgcgta cgcggccgct cgagagcgct       562
Cys His Cys Glu Glu Cys Ser Ser                                           
    125                 130                                               

aagctccgag ggccgccacc acctgttcct gtacggcatg gacgagctgt acaagtaaga      622

attcgatatc ggatccgcag atcccggcca gataccgatg ctgccgcagc aaaagcagga      682

gcagatgccg ccgtcgcagg cgaagatgtc gcagacggag gaggcgatgc tgccggcgga      742

ggaggcgaag taagtagagg gctgggctgg gctgtggggg gtgtggggtg cgggactggg      802

cagtctggga gtccctctca ccacttttct tacctttcta ggatgctgcc gtcgccgccg      862

ctcatacacc ataaggtgta aaaantacta gatgcacaga atagcaagtc catcaaaact      922

cctgcgtgag aattttacca gacttcaaga gcatctcgcc acatcttgaa aaatgccacc      982

gtccgatgaa aaacaggagc ctgctaagga acaatgccac ctgtcaataa atgttgaaaa     1042

ctcatcccat tcctgcctct tggtccttgg gctt                                 1076


<210> 6
<211> 133
<212> PRT
<213> Homo sapiens

<400> 6
Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210> 7
<211> 131
<212> PRT
<213> Mus musculus

<400> 7
Met Arg Asn His Val Leu Ala Ala Ser Ile Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Ala Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Leu Met 
            20                  25                  30          


Asp Ser Gln Arg Cys Met Arg His His Tyr Val Asp Ser Ile Ser His 
        35                  40                  45              


Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg Cys Glu 
    50                  55                  60                  


Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser Phe Ser 
65                  70                  75                  80  


Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys Arg Pro 
                85                  90                  95      


Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly Gly Met 
            100                 105                 110         


Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys Glu Glu 
        115                 120                 125             


Cys Ser Ser 
    130     


<210> 8
<211> 3089
<212> DNA
<213> Homo sapiens

<400> 8
attccctccc tggtgctcgc agaggactgg cccctctccg ggctgggagc tccggccgag       60

cggaggcgcg acggagagca ccagcgcagg gcagagagcc cggagcgacc ggccagagta      120

gggcatccgc tcgggtgctg cggagaacga gggcagctcc gagccgcccc ggaggaccga      180

tgcgccgggt ggggcgctgg ccccgagggc gtgagccgtc cgcagattga gcaacttggg      240

aacgggcggg cggagcgcag gcgagccggg cgcccaggac agtcccgcag cgggcgggtg      300

agcgggccgc gccctcgccc ctcccgggcc tgcccccgtc gcgactggca gcacgaagct      360

gagattgtgg tttcctggtg attcaggtgg gagtgggcca gaagatcacc gctggcaagg      420

actggtgttt gtcaactgta aggactcatg gaacagatct accagggatt ctcagacctt      480

agtttgagaa atgctgcaat taaaggcaaa tcctatcact ctgagtgatc gctttggtgt      540

cgaggcaatc aaccataaag ataaatgcaa atatggaaat tgcataacag tactcagtat      600

taaggttggt ttttggagta gtccctgctg acgtgacaaa aagatctctc atatgatatt      660

ccgaggtatc tttgaggaag tctctctttg aggacctccc tttgagctga tggagaactg      720

ggctccccac accctctctg tccccagctg agattatggt ggatttgggc tacggcccag      780

gcctgggcct cctgctgctg acccagcccc agaggtgtta gcaagagccg tgtgctatcc      840

accctccccg agaccacccc tccgaccagg ggcctggagc tggcgcgtga ctatgcggct      900

tgggctgtgt gtggtggccc tggttctgag ctggacgcac ctcaccatca gcagccgggg      960

gatcaagggg aaaaggcaga ggcggatcag tgccgagggg agccaggcct gtgccaaagg     1020

ctgtgagctc tgctctgaag tcaacggctg cctcaagtgc tcacccaagc tgttcatcct     1080

gctggagagg aacgacatcc gccaggtggg cgtctgcttg ccgtcctgcc cacctggata     1140

cttcgacgcc cgcaaccccg acatgaacaa gtgcatcaaa tgcaagatcg agcactgtga     1200

ggcctgcttc agccataact tctgcaccaa gtgtaaggag ggcttgtacc tgcacaaggg     1260

ccgctgctat ccagcttgtc ccgagggctc ctcagctgcc aatggcacca tggagtgcag     1320

tagtcctgcg caatgtgaaa tgagcgagtg gtctccgtgg gggccctgct ccaagaagca     1380

gcagctctgt ggtttccgga ggggctccga ggagcggaca cgcagggtgc tacatgcccc     1440

tgtgggggac catgctgcct gctctgacac caaggagacc cggaggtgca cagtgaggag     1500

agtgccgtgt cctgaggggc agaagaggag gaagggaggc cagggccggc gggagaatgc     1560

caacaggaac ctggccagga aggagagcaa ggaggcgggt gctggctctc gaagacgcaa     1620

ggggcagcaa cagcagcagc agcaagggac agtggggcca ctcacatctg cagggcctgc     1680

ctagggacac tgtccagcct ccaggcccat gcagaaagag ttcagtgcta ctctgcgtga     1740

ttcaagcttt cctgaactgg aacgtcgggg gcaaagcata cacacacact ccaatccatc     1800

catgcataca tagacacaag acacacacgc tcaaacccct gtccacatat acaaccatac     1860

atacttgcac atgtgtgttc atgtacacac gcagacacag acaccacaca cacacataca     1920

cacacacaca cacacacacc tgaggccacc agaagacact tccatccctc gggcccagca     1980

gtacacactt ggtttccaga gctcccagtg gacatgtcag agacaacact tcccagcatc     2040

tgagaccaaa ctgcagaggg gagccttctg gagaagctgc tgggatcgga ccagccactg     2100

tggcagatgg gagccaagct tgaggactgc tggtgacctg ggaagaaacc ttcttcccat     2160

cctgttcagc actcccagct gtgtgacttt atcgttggag agtattgtta cccttccagg     2220

atacatatca gggttaacct gactttgaaa actgcttaaa ggtttatttc aaattaaaac     2280

aaaaaaatca acgacagcag tagacacagg caccacattc ctttgcaggg tgtgagggtt     2340

tggcgaggta tgcgtaggag caagaaggga cagggaattt caagagaccc caaatagcct     2400

gctcagtaga gggtcatgca gacaaggaag aaaacttagg ggctgctctg acggtggtaa     2460

acaggctgtc tatatccttg ttactcagag catggcccgg cagcagtgtt gtcacagggc     2520

agcttgttag gaatgagaat ctcaggtctc attccagacc tggtgagcca gagtctaaat     2580

tttaagattc ctgatgattg gcatgttacc caaatttgag aagtgctgct gtaattcccc     2640

ttaaaggacg ggagaaaggg ccccggccat cttgcagcag gagggattct ggtcagctat     2700

aaaggaggac tttccatctg ggagaggcag aatctatata ctgaagggct agtggcactg     2760

ccaggggaag ggagtgcgta ggcttccagt gatggttggg gacaatcctg cccaaaggca     2820

gggcagtgga tggaataact ccttgtggca ttctgaagtg tgtgccaggc tctggactag     2880

gtgctaggtt tccagggagg agccaaacac gggccttgct cttgtggagc ttagaggttg     2940

gtggggaaga aaataggcat gcaccaagga attgtacaaa cacatatata actacaaaag     3000

gatggtgcca agggcaggtg accactggca tctatgctta gctatgaaag tgaataaagc     3060

agaataaaaa taaaatactt tctctcagg                                       3089


<210> 9
<211> 2910
<212> DNA
<213> Homo sapiens

<400> 9
attccctccc tggtgctcgc agaggactgg cccctctccg ggctgggagc tccggccgag       60

cggaggcgcg acggagagca ccagcgcagg gcagagagcc cggagcgacc ggccagagta      120

gggcatccgc tcgggtgctg cggagaacga gggcagctcc gagccgcccc ggaggaccga      180

tgcgccgggt ggggcgctgg ccccgagggc gtgagccgtc cgcagattga gcaacttggg      240

aacgggcggg cggagcgcag gcgagccggg cgcccaggac agtcccgcag cgggcgggtg      300

agcgggccgc gccctcgccc ctcccgggcc tgcccccgtc gcgactggca gcacgaagct      360

gagattgtgg tttcctggtg attcaggtgg gagtgggcca gaagatcacc gctggcaagg      420

actgggttgg tttttggagt agtccctgct gacgtgacaa aaagatctct catatgatat      480

tccgaggtat ctttgaggaa gtctctcttt gaggacctcc ctttgagctg atggagaact      540

gggctcccca caccctctct gtccccagct gagattatgg tggatttggg ctacggccca      600

ggcctgggcc tcctgctgct gacccagccc cagaggtgtt agcaagagcc gtgtgctatc      660

caccctcccc gagaccaccc ctccgaccag gggcctggag ctggcgcgtg actatgcggc      720

ttgggctgtg tgtggtggcc ctggttctga gctggacgca cctcaccatc agcagccggg      780

ggatcaaggg gaaaaggcag aggcggatca gtgccgaggg gagccaggcc tgtgccaaag      840

gctgtgagct ctgctctgaa gtcaacggct gcctcaagtg ctcacccaag ctgttcatcc      900

tgctggagag gaacgacatc cgccaggtgg gcgtctgctt gccgtcctgc ccacctggat      960

acttcgacgc ccgcaacccc gacatgaaca agtgcatcaa atgcaagatc gagcactgtg     1020

aggcctgctt cagccataac ttctgcacca agtgtaagga gggcttgtac ctgcacaagg     1080

gccgctgcta tccagcttgt cccgagggct cctcagctgc caatggcacc atggagtgca     1140

gtagtcctgc gcaatgtgaa atgagcgagt ggtctccgtg ggggccctgc tccaagaagc     1200

agcagctctg tggtttccgg aggggctccg aggagcggac acgcagggtg ctacatgccc     1260

ctgtggggga ccatgctgcc tgctctgaca ccaaggagac ccggaggtgc acagtgagga     1320

gagtgccgtg tcctgagggg cagaagagga ggaagggagg ccagggccgg cgggagaatg     1380

ccaacaggaa cctggccagg aaggagagca aggaggcggg tgctggctct cgaagacgca     1440

aggggcagca acagcagcag cagcaaggga cagtggggcc actcacatct gcagggcctg     1500

cctagggaca ctgtccagcc tccaggccca tgcagaaaga gttcagtgct actctgcgtg     1560

attcaagctt tcctgaactg gaacgtcggg ggcaaagcat acacacacac tccaatccat     1620

ccatgcatac atagacacaa gacacacacg ctcaaacccc tgtccacata tacaaccata     1680

catacttgca catgtgtgtt catgtacaca cgcagacaca gacaccacac acacacatac     1740

acacacacac acacacacac ctgaggccac cagaagacac ttccatccct cgggcccagc     1800

agtacacact tggtttccag agctcccagt ggacatgtca gagacaacac ttcccagcat     1860

ctgagaccaa actgcagagg ggagccttct ggagaagctg ctgggatcgg accagccact     1920

gtggcagatg ggagccaagc ttgaggactg ctggtgacct gggaagaaac cttcttccca     1980

tcctgttcag cactcccagc tgtgtgactt tatcgttgga gagtattgtt acccttccag     2040

gatacatatc agggttaacc tgactttgaa aactgcttaa aggtttattt caaattaaaa     2100

caaaaaaatc aacgacagca gtagacacag gcaccacatt cctttgcagg gtgtgagggt     2160

ttggcgaggt atgcgtagga gcaagaaggg acagggaatt tcaagagacc ccaaatagcc     2220

tgctcagtag agggtcatgc agacaaggaa gaaaacttag gggctgctct gacggtggta     2280

aacaggctgt ctatatcctt gttactcaga gcatggcccg gcagcagtgt tgtcacaggg     2340

cagcttgtta ggaatgagaa tctcaggtct cattccagac ctggtgagcc agagtctaaa     2400

ttttaagatt cctgatgatt ggcatgttac ccaaatttga gaagtgctgc tgtaattccc     2460

cttaaaggac gggagaaagg gccccggcca tcttgcagca ggagggattc tggtcagcta     2520

taaaggagga ctttccatct gggagaggca gaatctatat actgaagggc tagtggcact     2580

gccaggggaa gggagtgcgt aggcttccag tgatggttgg ggacaatcct gcccaaaggc     2640

agggcagtgg atggaataac tccttgtggc attctgaagt gtgtgccagg ctctggacta     2700

ggtgctaggt ttccagggag gagccaaaca cgggccttgc tcttgtggag cttagaggtt     2760

ggtggggaag aaaataggca tgcaccaagg aattgtacaa acacatatat aactacaaaa     2820

ggatggtgcc aagggcaggt gaccactggc atctatgctt agctatgaaa gtgaataaag     2880

cagaataaaa ataaaatact ttctctcagg                                      2910


<210> 10
<211> 2589
<212> DNA
<213> Homo sapiens

<400> 10
attccctccc tggtgctcgc agaggactgg cccctctccg ggctgggagc tccggccgag       60

cggaggcgcg acggagagca ccagcgcagg gcagagagcc cggagcgacc ggccagagta      120

gggcatccgc tcgggtgctg cggagaacga gggcagctcc gagccgcccc ggaggaccga      180

tgcgccgggt ggggcgctgg ccccgagggc gtgagccgtc cgcagattga gcaacttggg      240

aacgggcggg cggagcgcag gcgagccggg cgcccaggac agtcccgcag cgggcgggtg      300

agcgggccgc gccctcgccc ctcccgggcc tgcccccgtc gcgactggca gcacgaagct      360

gagattgtgg tttcctggtg attcaggtgg gagtgggcca gaagatcacc gctggcaagg      420

actgggttgg tttttggagt agtccctgct gacgtgacaa aaagatctct catatgatat      480

tccgagtcag tgccgagggg agccaggcct gtgccaaagg ctgtgagctc tgctctgaag      540

tcaacggctg cctcaagtgc tcacccaagc tgttcatcct gctggagagg aacgacatcc      600

gccaggtggg cgtctgcttg ccgtcctgcc cacctggata cttcgacgcc cgcaaccccg      660

acatgaacaa gtgcatcaaa tgcaagatcg agcactgtga ggcctgcttc agccataact      720

tctgcaccaa gtgtaaggag ggcttgtacc tgcacaaggg ccgctgctat ccagcttgtc      780

ccgagggctc ctcagctgcc aatggcacca tggagtgcag tagtcctgcg caatgtgaaa      840

tgagcgagtg gtctccgtgg gggccctgct ccaagaagca gcagctctgt ggtttccgga      900

ggggctccga ggagcggaca cgcagggtgc tacatgcccc tgtgggggac catgctgcct      960

gctctgacac caaggagacc cggaggtgca cagtgaggag agtgccgtgt cctgaggggc     1020

agaagaggag gaagggaggc cagggccggc gggagaatgc caacaggaac ctggccagga     1080

aggagagcaa ggaggcgggt gctggctctc gaagacgcaa ggggcagcaa cagcagcagc     1140

agcaagggac agtggggcca ctcacatctg cagggcctgc ctagggacac tgtccagcct     1200

ccaggcccat gcagaaagag ttcagtgcta ctctgcgtga ttcaagcttt cctgaactgg     1260

aacgtcgggg gcaaagcata cacacacact ccaatccatc catgcataca tagacacaag     1320

acacacacgc tcaaacccct gtccacatat acaaccatac atacttgcac atgtgtgttc     1380

atgtacacac gcagacacag acaccacaca cacacataca cacacacaca cacacacacc     1440

tgaggccacc agaagacact tccatccctc gggcccagca gtacacactt ggtttccaga     1500

gctcccagtg gacatgtcag agacaacact tcccagcatc tgagaccaaa ctgcagaggg     1560

gagccttctg gagaagctgc tgggatcgga ccagccactg tggcagatgg gagccaagct     1620

tgaggactgc tggtgacctg ggaagaaacc ttcttcccat cctgttcagc actcccagct     1680

gtgtgacttt atcgttggag agtattgtta cccttccagg atacatatca gggttaacct     1740

gactttgaaa actgcttaaa ggtttatttc aaattaaaac aaaaaaatca acgacagcag     1800

tagacacagg caccacattc ctttgcaggg tgtgagggtt tggcgaggta tgcgtaggag     1860

caagaaggga cagggaattt caagagaccc caaatagcct gctcagtaga gggtcatgca     1920

gacaaggaag aaaacttagg ggctgctctg acggtggtaa acaggctgtc tatatccttg     1980

ttactcagag catggcccgg cagcagtgtt gtcacagggc agcttgttag gaatgagaat     2040

ctcaggtctc attccagacc tggtgagcca gagtctaaat tttaagattc ctgatgattg     2100

gcatgttacc caaatttgag aagtgctgct gtaattcccc ttaaaggacg ggagaaaggg     2160

ccccggccat cttgcagcag gagggattct ggtcagctat aaaggaggac tttccatctg     2220

ggagaggcag aatctatata ctgaagggct agtggcactg ccaggggaag ggagtgcgta     2280

ggcttccagt gatggttggg gacaatcctg cccaaaggca gggcagtgga tggaataact     2340

ccttgtggca ttctgaagtg tgtgccaggc tctggactag gtgctaggtt tccagggagg     2400

agccaaacac gggccttgct cttgtggagc ttagaggttg gtggggaaga aaataggcat     2460

gcaccaagga attgtacaaa cacatatata actacaaaag gatggtgcca agggcaggtg     2520

accactggca tctatgctta gctatgaaag tgaataaagc agaataaaaa taaaatactt     2580

tctctcagg                                                             2589


<210> 11
<211> 2721
<212> DNA
<213> Homo sapiens

<400> 11
attccctccc tggtgctcgc agaggactgg cccctctccg ggctgggagc tccggccgag       60

cggaggcgcg acggagagca ccagcgcagg gcagagagcc cggagcgacc ggccagagta      120

gggcatccgc tcgggtgctg cggagaacga gggcagctcc gagccgcccc ggaggaccga      180

tgcgccgggt ggggcgctgg ccccgagggc gtgagccgtc cgcagattga gcaacttggg      240

aacgggcggg cggagcgcag gcgagccggg cgcccaggac agtcccgcag cgggcgggtg      300

agcgggccgc gccctcgccc ctcccgggcc tgcccccgtc gcgactggca gcacgaagct      360

gagattgtgg tttcctggtg attcaggtgg gagtgggcca gaagatcacc gctggcaagg      420

actgggttgg tttttggagt agtccctgct gacgtgacaa aaagatctct catatgatat      480

tccgaggtat ctttgaggaa gtctctcttt gaggacctcc ctttgagctg atggagaact      540

gggctcccca caccctctct gtccccagct gagattatgg tggatttggg ctacggccca      600

ggcctgggcc tcctgctgct gacccagccc cagaggtgtt agcaagagcc gtgtgctatc      660

caccctcccc gagaccaccc ctccgaccag gggcctggag ctggcgcgtg actatgcggc      720

ttgggctgtg tgtggtggcc ctggttctga gctggacgca cctcaccatc agcagccggg      780

ggatcaaggg gaaaaggcag aggcggatca gtgccgaggg gagccaggcc tgtgccaaag      840

gctgtgagct ctgctctgaa gtcaacggct gcctcaagtg ctcacccaag ctgttcatcc      900

tgctggagag gaacgacatc cgccaggtgg gcgtctgctt gccgtcctgc ccacctggat      960

acttcgacgc ccgcaacccc gacatgaaca agtgcatcaa atgcaagatc gagcactgtg     1020

aggcctgctt cagccataac ttctgcacca agtgtaagga gggcttgtac ctgcacaagg     1080

gccgctgcta tccagcttgt cccgagggct cctcagctgc caatggcacc atggagtgca     1140

gtagtcctgg gcagaagagg aggaagggag gccagggccg gcgggagaat gccaacagga     1200

acctggccag gaaggagagc aaggaggcgg gtgctggctc tcgaagacgc aaggggcagc     1260

aacagcagca gcagcaaggg acagtggggc cactcacatc tgcagggcct gcctagggac     1320

actgtccagc ctccaggccc atgcagaaag agttcagtgc tactctgcgt gattcaagct     1380

ttcctgaact ggaacgtcgg gggcaaagca tacacacaca ctccaatcca tccatgcata     1440

catagacaca agacacacac gctcaaaccc ctgtccacat atacaaccat acatacttgc     1500

acatgtgtgt tcatgtacac acgcagacac agacaccaca cacacacata cacacacaca     1560

cacacacaca cctgaggcca ccagaagaca cttccatccc tcgggcccag cagtacacac     1620

ttggtttcca gagctcccag tggacatgtc agagacaaca cttcccagca tctgagacca     1680

aactgcagag gggagccttc tggagaagct gctgggatcg gaccagccac tgtggcagat     1740

gggagccaag cttgaggact gctggtgacc tgggaagaaa ccttcttccc atcctgttca     1800

gcactcccag ctgtgtgact ttatcgttgg agagtattgt tacccttcca ggatacatat     1860

cagggttaac ctgactttga aaactgctta aaggtttatt tcaaattaaa acaaaaaaat     1920

caacgacagc agtagacaca ggcaccacat tcctttgcag ggtgtgaggg tttggcgagg     1980

tatgcgtagg agcaagaagg gacagggaat ttcaagagac cccaaatagc ctgctcagta     2040

gagggtcatg cagacaagga agaaaactta ggggctgctc tgacggtggt aaacaggctg     2100

tctatatcct tgttactcag agcatggccc ggcagcagtg ttgtcacagg gcagcttgtt     2160

aggaatgaga atctcaggtc tcattccaga cctggtgagc cagagtctaa attttaagat     2220

tcctgatgat tggcatgtta cccaaatttg agaagtgctg ctgtaattcc ccttaaagga     2280

cgggagaaag ggccccggcc atcttgcagc aggagggatt ctggtcagct ataaaggagg     2340

actttccatc tgggagaggc agaatctata tactgaaggg ctagtggcac tgccagggga     2400

agggagtgcg taggcttcca gtgatggttg gggacaatcc tgcccaaagg cagggcagtg     2460

gatggaataa ctccttgtgg cattctgaag tgtgtgccag gctctggact aggtgctagg     2520

tttccaggga ggagccaaac acgggccttg ctcttgtgga gcttagaggt tggtggggaa     2580

gaaaataggc atgcaccaag gaattgtaca aacacatata taactacaaa aggatggtgc     2640

caagggcagg tgaccactgg catctatgct tagctatgaa agtgaataaa gcagaataaa     2700

aataaaatac tttctctcag g                                               2721


<210> 12
<211> 1834
<212> DNA
<213> Mus musculus

<400> 12
ggattccctc cctcgtgcga gccggggacc ggcccctctc cgggcgcggg gcgcagagcc       60

cgggcggcgc actgcggggc ccgcgcgggc cgccccagca ccaatgcacc gggcggggcg      120

ctggcggccg agaaggcatt gagcaactgg gcggcgggcg gagcgcgggg ccgacggcaa      180

cgcgggaccc agtggccgcg ccctcgcccc tccgggctgc cccgccacgg ccgctgcgcc      240

aggtctatct tgggggtggt tctctgctgg cgtgagaaga cttctcatgt gaccctctga      300

ggtggattca agcaggacag gacctccctt tggaccaatg gagaagccgg ctccaaaccc      360

tctcggatcc cagctaaggt tatggtggat ccgggcctgg ctctcctgcc actgacccag      420

cctcagagcc ttttagcaag agaccacccc tcctgccagg ggcccggggc tggccagtga      480

ctatgcggct tgggctgtgc gtggtggccc tggttctgag ctggacacac atcgccgtgg      540

gcagccgggg gatcaagggc aagagacaga ggcggatcag tgctgagggg agccaagcct      600

gcgccaaggg ctgtgagctc tgttcagaag tcaacggttg cctcaagtgc tcgcccaagc      660

tcttcattct gctggagagg aacgacatcc gccaggtggg cgtctgcctg ccgtcctgcc      720

cacctggata ctttgatgcc cgcaaccccg acatgaacaa atgcatcaaa tgcaagatcg      780

agcactgtga ggcctgcttc agccacaact tctgcaccaa gtgtcaggag ggcttgtact      840

tacacaaggg ccgctgctat ccagcctgcc ctgagggctc tacagccgct aacagcacca      900

tggagtgcgg cagtcctgca caatgtgaaa tgagcgagtg gtccccgtgg ggaccctgct      960

ccaagaagag gaagctgtgc ggtttccgga agggatcgga agagcggaca cgcagagtgc     1020

tccatgctcc cgggggagac cacaccacct gctccgacac caaagagacc cgcaagtgta     1080

ccgtgcgcag gacgccctgc ccagaggggc agaagaggag gaaggggggc cagggccgga     1140

gggagaatgc caacaggcat ccggccagga agaacagcaa ggagccgggc tccaactctc     1200

ggagacacaa agggcaacag cagccacagc cagggacaac agggccactc acatcagtag     1260

gacctacctg ggcacagtga ccggtctcca gatacctgtg gaagagtaca gtgctgtact     1320

gtataatgag aactttccag aactggagca tctgggagag tccacacata ccccatccac     1380

ccacccatcc aactatccat ccatccatcc atgcacacat atggccacat ctgaaaacgt     1440

caacacacac acacacacac acacacacac acacacacat tcttgaggtc actgaagaca     1500

cttctattct gtggcccagc tgtatattca gtctttaatg ctcttggaag acatatctga     1560

gagaaccttt cccagcatct gaaactaagg agtggaacct tctggaggaa cttctgggac     1620

agcatctgac agatggatgg cagattggag ccaaagctgg agcagctgcc gagagggaga     1680

gagagggaaa gcgctttccc ggcttgagag gcactcccag ctgtgagact tgattgtcgg     1740

agatgagaat tattacacat ccgtggtaca cgtcacggat gacctgactt ggaaactgct     1800

taaaggttta tttcaaatta aaaaagagaa aaac                                 1834


<210> 13
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Val Leu Leu Ala Arg Cys Glu Gly His Cys Ser Gln Ala Ser Arg 
1               5                   10                  15      


Ser Glu Pro Leu Val Ser Phe Ser Thr Val Leu Lys Gln Pro Phe Arg 
            20                  25                  30          


Ser Ser Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu 
        35                  40                  45              


Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr 
    50                  55                  60                  


Ile Leu Ser Cys His Cys Glu Glu Cys Asn Ser Gly Pro Leu Leu Cys 
65                  70                  75                  80  


Val Ala Ser Gly Trp Asp Asn Cys Arg Gly Ser Ser Thr Ser Gln Gly 
                85                  90                  95      


Lys Thr Gly Lys Lys Arg Val Lys Ala Lys Lys Asp Ala Thr Ile Leu 
            100                 105                 110         


Pro Gly Leu Cys Ile Phe 
        115             


<210> 14
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Leu Arg Gly His Ala Thr His Cys His Leu Pro Val His Pro Leu 
1               5                   10                  15      


Leu Ser Leu Arg Gly Met Gln Phe Leu Arg Pro Ala Ala Val Cys Gly 
            20                  25                  30          


Phe Trp Met Gly Gln Leu 
        35              


<210> 15
<211> 263
<212> PRT
<213> Homo sapiens

<400> 15
Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      


Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          


Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              


Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  


Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  


Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      


Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             


Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser 
    130                 135                 140                 


Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser 
145                 150                 155                 160 


Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr 
                165                 170                 175     


Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp 
            180                 185                 190         


Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu 
        195                 200                 205             


Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn 
    210                 215                 220                 


Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg 
225                 230                 235                 240 


Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly Pro 
                245                 250                 255     


Leu Thr Ser Ala Gly Pro Ala 
            260             


<210> 16
<211> 265
<212> PRT
<213> Mus musculus

<400> 16
Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      


Ile Ala Val Gly Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          


Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              


Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  


Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  


Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      


Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Gln Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             


Cys Pro Glu Gly Ser Thr Ala Ala Asn Ser Thr Met Glu Cys Gly Ser 
    130                 135                 140                 


Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser 
145                 150                 155                 160 


Lys Lys Arg Lys Leu Cys Gly Phe Arg Lys Gly Ser Glu Glu Arg Thr 
                165                 170                 175     


Arg Arg Val Leu His Ala Pro Gly Gly Asp His Thr Thr Cys Ser Asp 
            180                 185                 190         


Thr Lys Glu Thr Arg Lys Cys Thr Val Arg Arg Thr Pro Cys Pro Glu 
        195                 200                 205             


Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn 
    210                 215                 220                 


Arg His Pro Ala Arg Lys Asn Ser Lys Glu Pro Gly Ser Asn Ser Arg 
225                 230                 235                 240 


Arg His Lys Gly Gln Gln Gln Pro Gln Pro Gly Thr Thr Gly Pro Leu 
                245                 250                 255     


Thr Ser Val Gly Pro Thr Trp Ala Gln 
            260                 265 


