                               SEQUENCE LISTING

<110> GOLDFINCH BIO, INC.
 
<120> PYRIDAZINONES AND METHODS OF USE THEREOF

<130> GFX-01125

<140> PCT/US2019/051680
<141> 2019-09-18

<150> 62/780,553
<151> 2018-12-17

<150> 62/732,728
<151> 2018-09-18

<160> 2     

<170> PatentIn version 3.5

<210> 1
<211> 8574
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ccctatcagt gatagagatc      840

tccctatcag tgatagagat cgtcgacgag ctcgtttagt gaaccgtcag atcgcctgga      900

gacgccatcc acgctgtttt gacctccata gaagacaccg ggaccgatcc agcctccgga      960

ctctagcgtt taaacttaag cttggtaccg agctcggatc cgccaccatg gcccagttct     1020

actataagag aaacgtgaat gccccttacc gcgacagaat ccccctgaga atcgtgaggg     1080

cagagtccga gctgagccca tccgagaagg cctacctgaa cgccgtggag aagggcgact     1140

atgccagcgt gaagaagtcc ctggaggagg ccgagatcta ctttaagatc aacatcaatt     1200

gcatcgatcc tctgggcaga accgccctgc tgatcgccat cgagaacgag aatctggagc     1260

tgatcgagct gctgctgagc ttcaacgtgt atgtgggcga tgccctgctg cacgccatca     1320

ggaaggaggt ggtgggagca gtggagctgc tgctgaatca caagaagcca agcggagaga     1380

agcaggtgcc acctatcctg ctggacaagc agttctccga gtttacccca gatatcacac     1440

ccatcatcct ggccgcccac accaacaatt acgagatcat caagctgctg gtgcagaagg     1500

gcgtgtccgt gcctcgccca cacgaggtgc ggtgcaactg cgtggagtgc gtgagctcct     1560

ctgacgtgga ttctctgagg cacagccgga gccggctgaa catctataag gccctggcct     1620

ccccatctct gatcgccctg agctccgagg accccttcct gaccgccttt cagctgtctt     1680

gggagctgca ggagctgagc aaggtggaga acgagtttaa gagcgagtac gaggagctgt     1740

ccagacagtg caagcagttc gccaaggacc tgctggatca gacacgctct agccgggagc     1800

tggagatcat cctgaactat agggacgata attctctgat cgaggagcag agcggaaacg     1860

acctggcacg cctgaagctg gccatcaagt accggcagaa ggagttcgtg gcccagccta     1920

attgtcagca gctgctggcc tcccgctggt atgatgagtt tccaggatgg cggagaaggc     1980

actgggcagt gaagatggtg acctgcttca tcatcggcct gctgttcccc gtgttcagcg     2040

tgtgctacct gatcgcccct aagtctccac tgggcctgtt tatccggaag cctttcatca     2100

agtttatctg ccacaccgcc agctatctga cattcctgtt tctgctgctg ctggcctccc     2160

agcacatcga cagatctgat ctgaacaggc agggcccacc ccctaccatc gtggagtgga     2220

tgatcctgcc atgggtgctg ggcttcatct ggggcgagat caagcagatg tgggacggcg     2280

gcctgcagga ctacatccac gattggtgga acctgatgga ttttgtgatg aattccctgt     2340

acctggccac aatctctctg aagatcgtgg ccttcgtgaa gtatagcgcc ctgaatccca     2400

gagagtcctg ggacatgtgg caccctaccc tggtggcaga ggccctgttc gcaatcgcca     2460

acatcttttc ctctctgcgc ctgatcagcc tgtttacagc caattcccac ctgggaccac     2520

tgcagatctc cctgggacgg atgctgctgg atatcctgaa gttcctgttt atctactgcc     2580

tggtgctgct ggccttcgcc aacggcctga atcagctgta cttctactat gaggagacca     2640

agggcctgac atgcaagggc atccgctgtg agaagcagaa caatgccttc agcaccctgt     2700

tcgagacact gcagtctctg ttctggagca tctttggcct gatcaacctg tacgtgacca     2760

atgtgaaggc ccagcacgag ttcacagagt ttgtgggcgc caccatgttc ggcacataca     2820

acgtgatctc tctggtggtg ctgctgaata tgctgatcgc catgatgaac aatagctatc     2880

agctgatcgc cgaccacgcc gatatcgagt ggaagttcgc ccggaccaag ctgtggatgt     2940

cctactttga ggagggcggc accctgccca cacctttcaa cgtgatccca tcccccaagt     3000

ctctgtggta tctgatcaag tggatctgga cacacctgtg caagaagaag atgcgccgga     3060

agcctgagag ctttggcacc atcggcgtgc gcacacagca cagaagggca gcagacaacc     3120

tgcgccggca ccaccagtac caggaagtga tgcgcaatct ggtgaagcgg tatgtggccg     3180

ccatgatcag ggacgcaaag accgaggagg gactgacaga ggagaacttc aaggagctga     3240

agcaggatat cagctccttc agatttgagg tgctgggcct gctgaggggc agcaagctgt     3300

ccaccatcca gtccgccaac gcctctaagg agtctagcaa ttctgccgac agcgatgaga     3360

agagcgactc cgagggcaac tctaaggata agaagaagaa cttcagcctg tttgacctga     3420

ccacactgat ccacccacgc agcgccgcaa tcgcatccga gcggcacaac atctccaatg     3480

gctctgccct ggtggtgcag gagccaccaa gagagaagca gaggaaggtg aactttgtga     3540

cagatatcaa gaatttcggc ctgtttcaca gaaggagcaa gcagaacgcc gccgagcaga     3600

acgccaatca gatcttctct gtgagcgagg aggtggcaag acagcaggca gcaggaccac     3660

tggagaggaa tatccagctg gagagccggg gactggcaag caggggcgac ctgtccatcc     3720

caggactgtc tgagcagtgc gtgctggtgg accacaggga gcggaacacc gatacactgg     3780

gactgcaagt gggcaagcgg gtgtgccctt tcaagagcga gaaggtcgtg gtggaggaca     3840

ccgtgcccat catccctaag gagaagcacg ccaaggagga ggattcctct atcgactacg     3900

atctgaatct gccagacacc gtgacacacg aggattatgt gaccacaagg ctgtgagcgg     3960

ccgctctaga gggcccgttt aaacccgctg atcagcctcg actgtgcctt ctagttgcca     4020

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     4080

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     4140

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     4200

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctctag     4260

ggggtatccc cacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     4320

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     4380

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     4440

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc     4500

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     4560

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc     4620

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     4680

acaaaaattt aacgcgaatt aattctgtgg aatgtgtgtc agttagggtg tggaaagtcc     4740

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccagg     4800

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     4860

tcagcaacca tagtcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc     4920

gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc     4980

tctgcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct aggcttttgc     5040

aaaaagctcc cgggagcttg tatatccatt ttcggatctg atcagcacgt gatgaaaaag     5100

cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc     5160

gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg     5220

cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt     5280

tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc     5340

agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg     5400

cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct     5460

gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa     5520

tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa     5580

actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt     5640

tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat     5700

gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg     5760

gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag     5820

cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg     5880

gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc     5940

gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact     6000

gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa     6060

gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cgagggcaaa ggaatagcac     6120

gtgctacgag atttcgattc caccgccgcc ttctatgaaa ggttgggctt cggaatcgtt     6180

ttccgggacg ccggctggat gatcctccag cgcggggatc tcatgctgga gttcttcgcc     6240

caccccaact tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat     6300

ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat     6360

gtatcttatc atgtctgtat accgtcgacc tctagctaga gcttggcgta atcatggtca     6420

tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga     6480

agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg     6540

cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc     6600

caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac     6660

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     6720

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     6780

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     6840

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     6900

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     6960

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     7020

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     7080

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     7140

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     7200

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga     7260

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     7320

tcttgatccg gcaaacaaac caccgctggt agcggttggt tttttgtttg caagcagcag     7380

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     7440

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     7500

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     7560

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     7620

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag     7680

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca     7740

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact     7800

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca     7860

gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg     7920

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc     7980

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg     8040

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca     8100

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt     8160

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc     8220

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc     8280

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca     8340

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa     8400

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat     8460

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa     8520

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtc           8574


<210> 2
<211> 8541
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ccctatcagt gatagagatc      840

tccctatcag tgatagagat cgtcgacgag ctcgtttagt gaaccgtcag atcgcctgga      900

gacgccatcc acgctgtttt gacctccata gaagacaccg ggaccgatcc agcctccgga      960

ctctagcgtt taaacttaag cccaagctgg ctagaccgcc atggcccaac tgtactacaa     1020

aaaggtcaac tactcaccgt acagagaccg catccccctg caaattgtga gggctgagac     1080

agagctctct gcagaggaga aggccttcct caatgctgtg gagaaggggg actatgccac     1140

tgtgaagcag gcccttcagg aggctgagat ctactataat gttaacatca actgcatgga     1200

ccccttgggc cggagtgccc tgctcattgc cattgagaac gagaacctgg agatcatgga     1260

gctactgctg aaccacagcg tgtatgtggg tgatgcattg ctctatgcca tacgcaagga     1320

agtggtgggc gctgtggagc ttctgctcag ctacaggcgg cccagcggag agaagcaggt     1380

ccccactctg atgatggaca cgcagttctc tgaattcaca ccggacatca ctcccatcat     1440

gctggctgcc cacaccaaca actacgaaat catcaaactg cttgtccaaa aacgggtcac     1500

tatcccacgg ccccaccaga tccgctgcaa ctgtgtggag tgtgtgtcta gttcagaggt     1560

agacagcctg cgccactctc gctcccgact gaacatctat aaggctctgg caagcccctc     1620

actcattgcc ttatcaagtg aggaccccat cctaactgcc ttccgtctgg gctgggagct     1680

caaggagctc agcaaggtgg agaatgagtt caaggccgag tatgaggagc tctctcagca     1740

gtgcaagctc tttgccaaag acctgctgga ccaagctcgg agctccaggg aactggagat     1800

catcctcaac catcgagatg accacagtga agagcttgac cctcagaagt accatgacct     1860

ggccaagttg aaggtggcaa tcaaatacca ccagaaagag tttgttgctc agcccaactg     1920

ccaacagttg cttgccaccc tgtggtatga tggcttccct ggatggcggc ggaaacactg     1980

ggtagtcaag cttctaacct gcatgaccat tgggttcctg tttcccatgc tgtctatagc     2040

ctacctgatc tcacccagga gcaaccttgg gctgttcatc aagaaaccct ttatcaagtt     2100

tatctgccac acagcatcct atttgacctt cctctttatg cttctcctgg cttctcagca     2160

cattgtcagg acagaccttc atgtacaggg gcctccccca actgtcgtgg aatggatgat     2220

attgccttgg gttctaggtt tcatttgggg tgagattaag gaaatgtggg atggtggatt     2280

tactgaatac atccatgact ggtggaacct gatggatttt gcaatgaact ccctctacct     2340

ggcaactatt tccctgaaga ttgtggccta tgtcaagtat aatggttctc gtccaaggga     2400

ggaatgggaa atgtggcacc cgactctgat tgcggaagca ctcttcgcaa tatccaacat     2460

tttaagttcg ttgcgtctca tatccctgtt cacagccaac tcccacttag gacctctgca     2520

gatctctttg ggacgcatgc tgcttgatat cctcaaattc ctctttatct actgcctggt     2580

actactagct tttgccaatg gactgaacca gctttacttc tattatgaaa ccagagctat     2640

cgatgagcct aacaactgca aggggatccg atgtgagaaa cagaacaatg ccttctccac     2700

gctctttgag actcttcagt cactcttctg gtctgtattt ggccttttaa atctatatgt     2760

caccaatgtg aaagccagac acgaattcac cgagtttgta ggagctacca tgtttggaac     2820

atacaatgtc atctccctgg tagtgctgct gaacatgctg attgctatga tgaacaactc     2880

ctatcagctt attgccgatc atgctgatat cgagtggaag tttgcaagga cgaagctctg     2940

gatgagttac tttgatgaag gtggcacctt gccacctcct ttcaacatca tccccagccc     3000

caagtcattt ctataccttg gtaactggtt caacaacacc ttctgcccca aaagagaccc     3060

tgacggtaga cggagaaggc gcaacttgag aagtttcaca gaacgcaatg ctgacagcct     3120

gatacaaaat caacattatc aggaagttat caggaattta gtcaaaagat atgtggctgc     3180

tatgataaga aattccaaaa cacatgaggg acttacagaa gaaaatttta aggaattaaa     3240

gcaagacatc tccagctttc ggtatgaagt gcttgacctc ttgggaaata gaaaacatcc     3300

aaggagcttt tccactagca gcactgaact gtctcagaga gacgataata atgatggcag     3360

tggtggggct cgggccaaat ccaagagtgt ctcttttaat ttaggctgca agaaaaagac     3420

ttgccatggg ccacctctca tcagaaccat gccaaggtcc agtggtgccc aaggaaagtc     3480

aaaagctgag tcatcaagca aacgctcctt catgggtcct tctctcaaga aactgggtct     3540

cctattctcc aaatttaatg gtcatatgtc tgaacccagt tcagagccaa tgtacacaat     3600

ttctgatgga attgttcagc agcactgtat gtggcaggac atcagatatt ctcagatgga     3660

gaaagggaaa gcagaggcct gttctcaaag tgaaattaac ctcagtgagg tagaattagg     3720

tgaagtccag ggcgctgctc agagcagtga atgccctcta gcctgttcca gctctcttca     3780

ctgtgcatcc agcatctgct cctcaaattc taaactttta gactcctcag aggatgtatt     3840

tgaaacttgg ggagaggctt gtgacttgct catgcacaaa tggggtgatg gacaggaaga     3900

acaagttaca actcgcctct aatgactcga gtctagaggg cccgtttaaa cccgctgatc     3960

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     4020

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     4080

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     4140

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga     4200

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt     4260

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc     4320

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca     4380

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc     4440

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt     4500

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac     4560

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc     4620

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat     4680

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc     4740

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga     4800

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc     4860

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt     4920

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga     4980

ggcttttttg gaggcctagg cttttgcaaa aagctcccgg gagcttgtat atccattttc     5040

ggatctgatc agcacgtgat gaaaaagcct gaactcaccg cgacgtctgt cgagaagttt     5100

ctgatcgaaa agttcgacag cgtctccgac ctgatgcagc tctcggaggg cgaagaatct     5160

cgtgctttca gcttcgatgt aggagggcgt ggatatgtcc tgcgggtaaa tagctgcgcc     5220

gatggtttct acaaagatcg ttatgtttat cggcactttg catcggccgc gctcccgatt     5280

ccggaagtgc ttgacattgg ggaattcagc gagagcctga cctattgcat ctcccgccgt     5340

gcacagggtg tcacgttgca agacctgcct gaaaccgaac tgcccgctgt tctgcagccg     5400

gtcgcggagg ccatggatgc gatcgctgcg gccgatctta gccagacgag cgggttcggc     5460

ccattcggac cgcaaggaat cggtcaatac actacatggc gtgatttcat atgcgcgatt     5520

gctgatcccc atgtgtatca ctggcaaact gtgatggacg acaccgtcag tgcgtccgtc     5580

gcgcaggctc tcgatgagct gatgctttgg gccgaggact gccccgaagt ccggcacctc     5640

gtgcacgcgg atttcggctc caacaatgtc ctgacggaca atggccgcat aacagcggtc     5700

attgactgga gcgaggcgat gttcggggat tcccaatacg aggtcgccaa catcttcttc     5760

tggaggccgt ggttggcttg tatggagcag cagacgcgct acttcgagcg gaggcatccg     5820

gagcttgcag gatcgccgcg gctccgggcg tatatgctcc gcattggtct tgaccaactc     5880

tatcagagct tggttgacgg caatttcgat gatgcagctt gggcgcaggg tcgatgcgac     5940

gcaatcgtcc gatccggagc cgggactgtc gggcgtacac aaatcgcccg cagaagcgcg     6000

gccgtctgga ccgatggctg tgtagaagta ctcgccgata gtggaaaccg acgccccagc     6060

actcgtccga gggcaaagga atagcacgtg ctacgagatt tcgattccac cgccgccttc     6120

tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc     6180

ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc ttataatggt     6240

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     6300

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc gtcgacctct     6360

agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc     6420

acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga     6480

gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg     6540

tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg     6600

cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     6660

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     6720

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     6780

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     6840

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     6900

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     6960

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     7020

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     7080

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     7140

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     7200

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     7260

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     7320

ggttggtttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     7380

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     7440

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     7500

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     7560

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc     7620

gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata     7680

ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg     7740

gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc     7800

cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct     7860

acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa     7920

cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt     7980

cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca     8040

ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac     8100

tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca     8160

atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt     8220

tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc     8280

actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca     8340

aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata     8400

ctcatactct tcctttttca atattattga agcatttatc agggttattg tctcatgagc     8460

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc     8520

cgaaaagtgc cacctgacgt c                                               8541


