                         SEQUENCE LISTING

<110>  CORNELL UNIVERSITY
 
<120>  METHODS OF COMPOSITIONS FOR TREATING LAMINOPATHIES AFFECTING 
       SKELETAL OR CARDIAC MUSCLE

<130>  147402.08231 (8242-01-PC)

<140>  PCT/US2019/050044
<141>  2019-09-11

<150>  62/728,472
<151>  2018-09-07

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 
1               5                   10                  15      


Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 
            20                  25                  30          


Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 
        35                  40                  45              


Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 
    50                  55                  60                  


Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 
65                  70                  75                  80  


Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 
                85                  90                  95      


Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 
            100                 105                 110         


Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 
        115                 120                 125             


Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
    130                 135                 140                 


Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
145                 150                 155                 160 


Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 
                165                 170                 175     


Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 
            180                 185                 190         


Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 
        195                 200                 205             


Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 
    210                 215                 220                 


Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 
225                 230                 235                 240 


Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 
                245                 250                 255     


Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 
            260                 265                 270         


Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 
        275                 280                 285             


His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 
    290                 295                 300                 


Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 
305                 310                 315                 320 


Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 
                325                 330                 335     


Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 
            340                 345                 350         


Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 
        355                 360                 365             


Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
    370                 375                 380                 


Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 
385                 390                 395                 400 


Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 
                405                 410                 415     


Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 
            420                 425                 430         


His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 
        435                 440                 445             


Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 
    450                 455                 460                 


Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 
465                 470                 475                 480 


Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 
                485                 490                 495     


Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 
            500                 505                 510         


Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 
        515                 520                 525             


Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 
    530                 535                 540                 


Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 
545                 550                 555                 560 


Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro 
                565                 570                 575     


Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly 
            580                 585                 590         


Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly 
        595                 600                 605             


Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg 
    610                 615                 620                 


Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn 
625                 630                 635                 640 


Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln 
                645                 650                 655     


Ser Pro Gln Asn Cys Ser Ile Met 
            660                 


<210>  2
<211>  634
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 
1               5                   10                  15      


Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 
            20                  25                  30          


Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 
        35                  40                  45              


Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 
    50                  55                  60                  


Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 
65                  70                  75                  80  


Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 
                85                  90                  95      


Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 
            100                 105                 110         


Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 
        115                 120                 125             


Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
    130                 135                 140                 


Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
145                 150                 155                 160 


Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 
                165                 170                 175     


Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 
            180                 185                 190         


Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 
        195                 200                 205             


Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 
    210                 215                 220                 


Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 
225                 230                 235                 240 


Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 
                245                 250                 255     


Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 
            260                 265                 270         


Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 
        275                 280                 285             


His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 
    290                 295                 300                 


Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 
305                 310                 315                 320 


Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 
                325                 330                 335     


Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 
            340                 345                 350         


Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 
        355                 360                 365             


Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
    370                 375                 380                 


Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 
385                 390                 395                 400 


Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 
                405                 410                 415     


Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 
            420                 425                 430         


His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 
        435                 440                 445             


Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 
    450                 455                 460                 


Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 
465                 470                 475                 480 


Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 
                485                 490                 495     


Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 
            500                 505                 510         


Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 
        515                 520                 525             


Ala Leu Ile Asn Ser Thr Gly Glu Gly Ser His Cys Ser Ser Ser Gly 
    530                 535                 540                 


Asp Pro Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr 
545                 550                 555                 560 


Cys Gly Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln 
                565                 570                 575     


Val Gly Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val 
            580                 585                 590         


Thr Arg Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly 
        595                 600                 605             


Asp Asn Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg 
    610                 615                 620                 


Thr Gln Ser Pro Gln Asn Cys Ser Ile Met 
625                 630                 


<210>  3
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 
1               5                   10                  15      


Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 
            20                  25                  30          


Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 
        35                  40                  45              


Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 
    50                  55                  60                  


Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 
65                  70                  75                  80  


Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 
                85                  90                  95      


Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 
            100                 105                 110         


Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 
        115                 120                 125             


Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
    130                 135                 140                 


Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
145                 150                 155                 160 


Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 
                165                 170                 175     


Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 
            180                 185                 190         


Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 
        195                 200                 205             


Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 
    210                 215                 220                 


Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 
225                 230                 235                 240 


Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 
                245                 250                 255     


Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 
            260                 265                 270         


Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 
        275                 280                 285             


His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 
    290                 295                 300                 


Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 
305                 310                 315                 320 


Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 
                325                 330                 335     


Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 
            340                 345                 350         


Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 
        355                 360                 365             


Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
    370                 375                 380                 


Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 
385                 390                 395                 400 


Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 
                405                 410                 415     


Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 
            420                 425                 430         


His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 
        435                 440                 445             


Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 
    450                 455                 460                 


Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 
465                 470                 475                 480 


Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 
                485                 490                 495     


Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 
            500                 505                 510         


Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 
        515                 520                 525             


Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 
    530                 535                 540                 


Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 
545                 550                 555                 560 


Leu Leu His His His His Val Ser Gly Ser Arg Arg 
                565                 570         


<210>  4
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Asn Ser Glu Gly Cys Asn Thr Lys Lys Glu Gly Asp Leu Ile 
1               5                   10                  15      


Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
            20                  25                  30          


Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
        35                  40                  45              


Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 
    50                  55                  60                  


Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 
65                  70                  75                  80  


Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 
                85                  90                  95      


Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 
            100                 105                 110         


Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 
        115                 120                 125             


Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 
    130                 135                 140                 


Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 
145                 150                 155                 160 


Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 
                165                 170                 175     


His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 
            180                 185                 190         


Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 
        195                 200                 205             


Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 
    210                 215                 220                 


Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 
225                 230                 235                 240 


Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 
                245                 250                 255     


Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
            260                 265                 270         


Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 
        275                 280                 285             


Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 
    290                 295                 300                 


Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 
305                 310                 315                 320 


His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 
                325                 330                 335     


Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 
            340                 345                 350         


Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 
        355                 360                 365             


Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 
    370                 375                 380                 


Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 
385                 390                 395                 400 


Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 
                405                 410                 415     


Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 
            420                 425                 430         


Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 
        435                 440                 445             


Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro 
    450                 455                 460                 


Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly 
465                 470                 475                 480 


Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly 
                485                 490                 495     


Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg 
            500                 505                 510         


Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn 
        515                 520                 525             


Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln 
    530                 535                 540                 


Ser Pro Gln Asn Cys Ser Ile Ile Gln Glu Met Gly Met Arg Trp Glu 
545                 550                 555                 560 


Val Glu Glu Gly Arg Arg Lys Val Ser Leu Ser Cys Leu Pro 
                565                 570                 


<210>  5
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nesprin1_HUMAN KASH Domain inhibitor

<400>  5

Arg Val Leu Arg Ala Ala Leu Pro Leu Gln Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ile Gly Leu Ala Cys Leu Val Pro Met Ser Glu Glu Asp Tyr Ser Cys 
            20                  25                  30          


Ala Leu Ser Asn Asn Phe Ala Arg Ser Phe His Pro Met Leu Arg Tyr 
        35                  40                  45              


Thr Asn Gly Pro Pro Pro Leu 
    50                  55  


<210>  6
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nesprin2_HUMAN KASH Domain inhibitor

<400>  6

Arg Val Val Arg Ala Ala Leu Pro Leu Gln Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ala Cys Leu Leu Pro Ser Ser Glu Glu Asp Tyr Ser Cys 
            20                  25                  30          


Thr Gln Ala Asn Asn Phe Ala Arg Ser Phe Tyr Pro Met Leu Arg Tyr 
        35                  40                  45              


Thr Asn Gly Pro Pro Pro Thr 
    50                  55  


<210>  7
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nesprin3_HUMAN KASH Domain inhibitor

<400>  7

Arg Ala Cys Cys Val Ala Leu Pro Leu Gln Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Leu Pro Ile Arg Glu Glu Asp Arg Ser Cys 
            20                  25                  30          


Thr Leu Ala Asn Asn Phe Ala Arg Ser Phe Thr Leu Met Leu Arg Tyr 
        35                  40                  45              


Asn Gly Pro Pro Pro Thr 
    50                  


<210>  8
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nesprin4_HUMAN KASH Domain inhibitor

<400>  8

Gln Pro Leu Thr Phe Leu Leu Ile Leu Phe Leu Leu Phe Leu Leu Leu 
1               5                   10                  15      


Val Gly Ala Met Phe Leu Leu Pro Ala Ser Gly Gly Pro Cys Cys Ser 
            20                  25                  30          


His Ala Arg Ile Pro Arg Thr Pro Tyr Leu Val Leu Ser Tyr Val Asn 
        35                  40                  45              


Gly Leu Pro Pro Val 
    50              


<210>  9
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANC1_CAEEL KASH Domain inhibitor

<400>  9

Arg Val Leu Arg Thr Ala Leu Pro Leu Gln Ala Leu Leu Val Leu Leu 
1               5                   10                  15      


Met Gly Ala Ala Cys Leu Val Pro His Cys Asp Asp Glu Tyr Cys Cys 
            20                  25                  30          


Gln Leu Leu Asn Asn Phe Ala Lys Ser Phe Asp Pro Ser Leu Glu Phe 
        35                  40                  45              


Val Asn Gly Pro Pro Pro Phe 
    50                  55  


<210>  10
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH5_HUMAN KASH Domain inhibitor

<400>  10

Arg Val Thr Arg His Pro Leu Ile Pro Ala Pro Val Leu Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Val Leu Leu Leu Gly Pro Ser Pro Pro Pro 
            20                  25                  30          


Thr Trp Pro His Leu Gln Leu Cys Tyr Leu Gln Pro Pro Pro Val 
        35                  40                  45          


<210>  11
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UNC83_CAEEL KASH Domain inhibitor

<400>  11

Arg Leu Ile Lys Phe Thr Phe Ala Leu Ser Leu Leu Ala Ala Leu Ala 
1               5                   10                  15      


Ala Ile Phe Tyr Tyr His Val Phe Gly Lys Pro Phe Gly Pro His Val 
            20                  25                  30          


Thr Tyr Val Asn Gly Pro Pro Pro Val 
        35                  40      


<210>  12
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nesprin4_MOUSE KASH Domain inhibitor

<400>  12

Leu Thr Leu Phe Phe Leu Leu Leu Phe Leu Leu Leu Val Gly Ala Thr 
1               5                   10                  15      


Leu Leu Leu Pro Leu Ser Gly Val Ser Cys Cys Ser His Ala Arg Leu 
            20                  25                  30          


Ala Arg Thr Pro Tyr Leu Val Leu Ser Tyr Val Asn Gly Leu Pro Pro 
        35                  40                  45              


Ile 
    


<210>  13
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sun1 Domain inhibitor

<400>  13

Met Asp Phe Ser Arg Leu His Thr Tyr Thr Pro Pro Gln Cys Val Pro 
1               5                   10                  15      


Glu Asn Thr Gly Tyr Thr Tyr Ala Leu Ser Ser Ser Tyr Ser Ser Asp 
            20                  25                  30          


Ala Leu Asp Phe Glu Thr Glu His Lys Leu Glu Pro Val Phe Asp Ser 
        35                  40                  45              


Pro Arg Met Ser Arg Arg Ser Leu Arg Leu Val Thr Thr Ala Ser Tyr 
    50                  55                  60                  


Ser Ser Gly Asp Ser Gln Ala Ile Asp Ser His Ile Ser Thr Ser Arg 
65                  70                  75                  80  


Ala Thr Pro Ala Lys Gly Arg Glu Thr Arg Thr Val Lys Gln Arg Arg 
                85                  90                  95      


Ser Ala Ser Lys Pro Ala Phe Ser Ile Asn His Leu Ser Gly Lys Gly 
            100                 105                 110         


Leu Ser Ser Ser Thr Ser His Asp Ser Ser Cys Ser Leu Arg Ser Ala 
        115                 120                 125             


Thr Val Leu Arg His Pro Val Leu Asp Glu Ser Leu Ile Arg Glu Gln 
    130                 135                 140                 


Thr Lys Val Asp His Phe Trp Gly Leu Asp Asp Asp Gly Asp Leu Lys 
145                 150                 155                 160 


Gly Gly Asn Lys Ala Ala Thr Gln Gly Asn Gly Glu Leu Ala Ala Glu 
                165                 170                 175     


Val 
    


<210>  14
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sun2 Domain inhibitor

<400>  14

Met Ser Arg Arg Ser Gln Arg Leu Thr Arg Tyr Ser Gln Asp Asp Asn 
1               5                   10                  15      


Asp Gly Gly Ser Ser Ser Ser Gly Ala Ser Ser Val Ala Gly Ser Gln 
            20                  25                  30          


Gly Thr Val Phe Lys Asp Ser Pro Leu Arg Thr Leu Lys Arg Lys Ser 
        35                  40                  45              


Ser Asn Met Lys His Leu Ser Pro Ala Pro Gln Leu Gly Pro Ser Ser 
    50                  55                  60                  


Asp Ser His Thr Ser Tyr Tyr Ser Glu Ser Val Val Arg Glu Ser Tyr 
65                  70                  75                  80  


Ile Gly Ser Pro Arg Ala Val Ser Leu Ala Arg Ser Ala Leu Leu Asp 
                85                  90                  95      


Asp His Leu His Ser Glu Pro Tyr Val Ser Gly Asp Leu Arg Gly Arg 
            100                 105                 110         


Arg Arg Arg Gly Thr Gly Gly 
        115                 


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kif5b#3 siRNA

<400>  15
cagcaagaag tagaccggat a                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kif5b#4 siRNA

<400>  16
cacgagctca cggttatgca a                                                 21


