                         SEQUENCE LISTING

<110>  UCL BUSINESS PLC
 
<120>  ANALYSIS METHOD

<130>  N413526WO

<150>  GB 1815111.8
<151>  2018-09-17

<160>  305   

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg 
1               5                   10                  15  


<210>  2
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly Leu Phe Leu 
1               5                   10                  15      


Ser Asp Asp Asp Pro Lys 
            20          


<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Ile Trp Leu Glu Ala Gly Lys 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Leu Asp Tyr Tyr Met Leu Arg 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Gly Asp Thr Met Glu Tyr Arg 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  6

Thr Ile Met Val Asp Asp Ser Lys 
1               5               


<210>  7
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr Val Thr Asp Met Leu Met Thr Ile Cys Ala Arg 
1               5                   10          


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Gly Ile Thr Asn His Asp Glu Tyr Ser Leu Val Arg 
1               5                   10              


<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Glu Ile Thr Gly Thr Leu Arg 
1               5               


<210>  10
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His Gly Arg 
1               5                   10                  


<210>  11
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu Leu Arg 
1               5                   10              


<210>  12
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  12

Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg 
1               5                   10      


<210>  13
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg 
1               5                   10              


<210>  14
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Asp Ile Leu Asn Gly Ser His Pro Val Ser Phe Asp Lys 
1               5                   10                  


<210>  15
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Cys Glu Phe Ala Gly Phe Gln Cys Gln Ile Gln Phe Gly Pro His 
1               5                   10                  15      


Asn Glu Gln Lys 
            20  


<210>  16
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  16

Asn Cys Gly Gln Met Ser Glu Ile Glu Ala Lys 
1               5                   10      


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Tyr Gly Val Ser Phe Phe Leu Val Lys 
1               5                   10  


<210>  18
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Val Ile Gln Glu Trp Asn Leu Thr Asn Ile Lys 
1               5                   10          


<210>  19
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Phe Thr Leu Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val 
1               5                   10                  15      


Gln Thr Thr Glu Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile 
            20                  25                  30          


Asp Ile Ile Leu Lys 
        35          


<210>  20
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp His Phe Gly Leu Glu Gly Asp Glu Glu Ser Thr Met Leu Glu Asp 
1               5                   10                  15      


Ser Val Ser Pro Lys 
            20      


<210>  21
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Thr Val Leu Gln Gln Gln Tyr Asn Arg 
1               5                   10  


<210>  22
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  22

Val Glu His Gly Ser Val Ala Leu Pro Ala Ile Met Arg 
1               5                   10              


<210>  23
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln Val Gly Ser Met Pro Pro 
1               5                   10                  15      


Ala Gln Gln Gln Ile Thr Ser Gly Gln Met His Arg 
            20                  25              


<210>  24
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu 
1               5                   10                  15      


Leu Gln Ala Ala Lys 
            20      


<210>  25
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
1               5                   10      


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg 
1               5                   10  


<210>  27
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Asn Leu Leu Gln Ala Ala Gly Asn Val Gly Gln Ala Ser Gly Glu 
1               5                   10                  15      


Leu Leu Gln Gln Ile Gly Glu Ser Asp Thr Asp Pro His Phe Gln Asp 
            20                  25                  30          


Ala Leu Met Gln Leu Ala Lys 
        35                  


<210>  28
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys 
1               5                   10          


<210>  29
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  29

Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala Ala Ala Thr Gln 
1               5                   10                  15      


Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr Lys 
            20                  25                  


<210>  30
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  30

Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu Val 
1               5                   10                  15      


Glu Ala Gly Arg 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Val Glu Gly Cys Val Ser Ala Ser Gln Ala Ala Thr Glu Asp Gly 
1               5                   10                  15      


Gln Leu Leu Arg 
            20  


<210>  32
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Val Gly Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu 
1               5                   10                  15      


Leu Gln His Val Lys 
            20      


<210>  33
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg 
1               5                   10      


<210>  34
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  34

Tyr Asp Gln Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe 
1               5                   10                  15      


Ser Ser Met Gly Asp Ala Gly Glu Met Val Arg 
            20                  25          


<210>  35
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  35

Ile Leu Ala Gln Ala Thr Ser Asp Leu Val Asn Ala Ile Lys 
1               5                   10                  


<210>  36
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Asp Ala Glu Gly Glu Ser Asp Leu Glu Asn Ser Arg 
1               5                   10              


<210>  37
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  37

Ile Leu Ala Asp Ala Thr Ala Lys 
1               5               


<210>  38
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Ala Ala Ala His Pro Asp Ser Glu Glu Gln Gln Gln Arg 
1               5                   10                  


<210>  39
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys 
1               5                   10          


<210>  40
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Ala Ala Ala Ser Ala Thr Gln Thr Ile Ala Ala Ala Gln His Ala 
1               5                   10                  15      


Ala Ser Thr Pro Lys 
            20      


<210>  41
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  41

Ala Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys 
1               5                   10                  


<210>  42
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Val Ala Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg 
1               5                   10                  


<210>  43
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  43

Gly Ser Gln Ala Gln Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile 
1               5                   10                  15      


Ala Ala Ser Gln Ser Phe Leu Gln Pro Gly Gly Lys 
            20                  25              


<210>  44
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Ser Val Pro Thr Ile Gln Asp Gln Ala Ser Ala Met Gln Leu Ser 
1               5                   10                  15      


Gln Cys Ala Lys 
            20  


<210>  45
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  45

Asn Leu Gly Thr Ala Leu Ala Glu Leu Arg 
1               5                   10  


<210>  46
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  46

Ala Gln Glu Ala Cys Gly Pro Leu Glu Met Asp Ser Ala Leu Ser Val 
1               5                   10                  15      


Val Gln Asn Leu Glu Lys 
            20          


<210>  47
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Lys Pro Leu Pro Gly Glu Thr Met Glu Lys 
1               5                   10      


<210>  48
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  48

Cys Thr Gln Asp Leu Gly Asn Ser Thr Lys 
1               5                   10  


<210>  49
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  49

Ala Val Ser Ser Ala Ile Ala Gln Leu Leu Gly Glu Val Ala Gln Gly 
1               5                   10                  15      


Asn Glu Asn Tyr Ala Gly Ile Ala Ala Arg 
            20                  25      


<210>  50
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Val Ala Ala Leu Thr Ser Asp Pro Ala Val Gln Ala Ile Val Leu 
1               5                   10                  15      


Asp Thr Ala Ser Asp Val Leu Asp Lys 
            20                  25  


<210>  51
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  51

Ala Ser Ser Leu Ile Glu Glu Ala Lys 
1               5                   


<210>  52
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  52

Ala Ala Gly His Pro Gly Asp Pro Glu Ser Gln Gln Arg 
1               5                   10              


<210>  53
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Val Thr Gln Ala Leu Asn Arg 
1               5               


<210>  54
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  54

Cys Val Ser Cys Leu Pro Gly Gln Arg 
1               5                   


<210>  55
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  55

Leu Leu Ser Asp Ser Leu Pro Pro Ser Thr Gly Thr Phe Gln Glu Ala 
1               5                   10                  15      


Gln Ser Arg 
            


<210>  56
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  56

Leu Asn Glu Ala Ala Ala Gly Leu Asn Gln Ala Ala Thr Glu Leu Val 
1               5                   10                  15      


Gln Ala Ser Arg 
            20  


<210>  57
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Thr Pro Gln Asp Leu Ala Arg 
1               5               


<210>  58
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  58

Phe Gly Gln Asp Phe Ser Thr Phe Leu Glu Ala Gly Val Glu Met Ala 
1               5                   10                  15      


Gly Gln Ala Pro Ser Gln Glu Asp Arg 
            20                  25  


<210>  59
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Gln Val Val Ser Asn Leu Lys 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Ile Ser Met Ser Ser Ser Lys 
1               5               


<210>  61
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  61

Ala Leu Ser Thr Asp Pro Ala Ala Pro Asn Leu Lys 
1               5                   10          


<210>  62
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  62

Ser Gln Leu Ala Ala Ala Ala Arg 
1               5               


<210>  63
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  63

Ala Val Thr Asp Ser Ile Asn Gln Leu Ile Thr Met Cys Thr Gln Gln 
1               5                   10                  15      


Ala Pro Gly Gln Lys 
            20      


<210>  64
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  64

Glu Leu Leu Glu Asn Pro Val Gln Pro Ile Asn Asp Met Ser Tyr Phe 
1               5                   10                  15      


Gly Cys Leu Asp Ser Val Met Glu Asn Ser Lys 
            20                  25          


<210>  65
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  65

Val Leu Gly Glu Ala Met Thr Gly Ile Ser Gln Asn Ala Lys 
1               5                   10                  


<210>  66
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  66

Asn Gly Asn Leu Pro Glu Phe Gly Asp Ala Ile Ser Thr Ala Ser Lys 
1               5                   10                  15      


<210>  67
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  67

Ala Leu Cys Gly Phe Thr Glu Ala Ala Ala Gln Ala Ala Tyr Leu Val 
1               5                   10                  15      


Gly Val Ser Asp Pro Asn Ser Gln Ala Gly Gln Gln Gly Leu Val Glu 
            20                  25                  30          


Pro Thr Gln Phe Ala Arg 
        35              


<210>  68
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Asn Gln Ala Ile Gln Met Ala Cys Gln Ser Leu Gly Glu Pro Gly 
1               5                   10                  15      


Cys Thr Gln Ala Gln Val Leu Ser Ala Ala Thr Ile Val Ala Lys 
            20                  25                  30      


<210>  69
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  69

His Thr Ser Ala Leu Cys Asn Ser Cys Arg 
1               5                   10  


<210>  70
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  70

Glu Val Ala Asn Ser Thr Ala Asn Leu Val Lys 
1               5                   10      


<210>  71
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  71

Ala Leu Asp Gly Ala Phe Thr Glu Glu Asn Arg 
1               5                   10      


<210>  72
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  72

Ala Ala Thr Ala Pro Leu Leu Glu Ala Val Asp Asn Leu Ser Ala Phe 
1               5                   10                  15      


Ala Ser Asn Pro Glu Phe Ser Ser Ile Pro Ala Gln Ile Ser Pro Glu 
            20                  25                  30          


Gly Arg 
        


<210>  73
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  73

Ala Ala Met Glu Pro Ile Val Ile Ser Ala Lys 
1               5                   10      


<210>  74
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  74

Thr Met Leu Glu Ser Ala Gly Gly Leu Ile Gln Thr Ala Arg 
1               5                   10                  


<210>  75
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  75

Asp Pro Pro Ser Trp Ser Val Leu Ala Gly His Ser Arg 
1               5                   10              


<210>  76
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Pro Gly Gln Leu Glu Cys Glu Thr Ala Ile Ala Ala Leu Asn Ser 
1               5                   10                  15      


Cys Leu Arg 
            


<210>  77
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  77

Asp Leu Asp Gln Ala Ser Leu Ala Ala Val Ser Gln Gln Leu Ala Pro 
1               5                   10                  15      


Arg 
    


<210>  78
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  78

Glu Gly Ile Ser Gln Glu Ala Leu His Thr Gln Met Leu Thr Ala Val 
1               5                   10                  15      


Gln Glu Ile Ser His Leu Ile Glu Pro Leu Ala Asn Ala Ala Arg 
            20                  25                  30      


<210>  79
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Glu Ala Ser Gln Leu Gly His Lys 
1               5                   


<210>  80
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  80

Val Ser Gln Met Ala Gln Tyr Phe Glu Pro Leu Thr Leu Ala Ala Val 
1               5                   10                  15      


Gly Ala Ala Ser Lys 
            20      


<210>  81
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  81

Thr Leu Ser His Pro Gln Gln Met Ala Leu Leu Asp Gln Thr Lys 
1               5                   10                  15  


<210>  82
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  82

Thr Leu Ala Glu Ser Ala Leu Gln Leu Leu Tyr Thr Ala Lys 
1               5                   10                  


<210>  83
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  83

Ala Ile Ala Val Thr Val Gln Glu Met Val Thr Lys 
1               5                   10          


<210>  84
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  84

Ser Asn Thr Ser Pro Glu Glu Leu Gly Pro Leu Ala Asn Gln Leu Thr 
1               5                   10                  15      


Ser Asp Tyr Gly Arg 
            20      


<210>  85
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  85

Leu Ala Ser Glu Ala Lys Pro Ala Ala Val Ala Ala Glu Asn Glu Glu 
1               5                   10                  15      


Ile Gly Ser His Ile Lys 
            20          


<210>  86
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  86

Val Gln Glu Leu Gly His Gly Cys Ala Ala Leu Val Thr Lys 
1               5                   10                  


<210>  87
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  87

Ala Gly Ala Leu Gln Cys Ser Pro Ser Asp Ala Tyr Thr Lys 
1               5                   10                  


<210>  88
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  88

Val Ser His Val Leu Ala Ala Leu Gln Ala Gly Asn Arg 
1               5                   10              


<210>  89
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  89

Gly Thr Gln Ala Cys Ile Thr Ala Ala Ser Ala Val Ser Gly Ile Ile 
1               5                   10                  15      


Ala Asp Leu Asp Thr Thr Ile Met Phe Ala Thr Ala Gly Thr Leu Asn 
            20                  25                  30          


Arg 
    


<210>  90
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  90

Glu Gly Thr Glu Thr Phe Ala Asp His Arg 
1               5                   10  


<210>  91
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  91

Val Leu Val Gln Asn Ala Ala Gly Ser Gln Glu Lys 
1               5                   10          


<210>  92
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  92

Leu Ala Gln Ala Ala Gln Ser Ser Val Ala Thr Ile Thr Arg 
1               5                   10                  


<210>  93
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  93

Leu Gly Ala Ala Ser Leu Gly Ala Glu Asp Pro Glu Thr Gln Val Val 
1               5                   10                  15      


Leu Ile Asn Ala Val Lys 
            20          


<210>  94
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  94

Ala Leu Gly Asp Leu Ile Ser Ala Thr Lys 
1               5                   10  


<210>  95
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  95

Val Gly Asp Asp Pro Ala Val Trp Gln Leu Lys 
1               5                   10      


<210>  96
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  96

Val Met Val Thr Asn Val Thr Ser Leu Leu Lys 
1               5                   10      


<210>  97
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  97

Ala Val Glu Asp Glu Ala Thr Lys 
1               5               


<210>  98
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  98

Ala Leu Glu Ala Thr Thr Glu His Ile Arg 
1               5                   10  


<210>  99
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  99

Gln Glu Leu Ala Val Phe Cys Ser Pro Glu Pro Pro Ala Lys 
1               5                   10                  


<210>  100
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  100

Thr Ser Thr Pro Glu Asp Phe Ile Arg 
1               5                   


<210>  101
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  101

Gly Ile Thr Met Ala Thr Ala Lys 
1               5               


<210>  102
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  102

Ala Val Ala Ala Gly Asn Ser Cys Arg 
1               5                   


<210>  103
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  103

Gln Glu Asp Val Ile Ala Thr Ala Asn Leu Ser Arg 
1               5                   10          


<210>  104
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  104

Glu Ala Ala Tyr His Pro Glu Val Ala Pro Asp Val Arg 
1               5                   10              


<210>  105
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  105

Glu Cys Ala Asn Gly Tyr Leu Glu Leu Leu Asp His Val Leu Leu Thr 
1               5                   10                  15      


Leu Gln Lys Pro Ser Pro Glu Leu Lys 
            20                  25  


<210>  106
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  106

Gln Gln Leu Thr Gly His Ser Lys 
1               5               


<210>  107
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  107

Val Ala Gly Ser Val Thr Glu Leu Ile Gln Ala Ala Glu Ala Met Lys 
1               5                   10                  15      


<210>  108
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  108

Gly Thr Glu Trp Val Asp Pro Glu Asp Pro Thr Val Ile Ala Glu Asn 
1               5                   10                  15      


Glu Leu Leu Gly Ala Ala Ala Ala Ile Glu Ala Ala Ala Lys 
            20                  25                  30  


<210>  109
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  109

Glu Ala Asp Glu Ser Leu Asn Phe Glu Glu Gln Ile Leu Glu Ala Ala 
1               5                   10                  15      


Lys 
    


<210>  110
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  110

Ser Ile Ala Ala Ala Thr Ser Ala Leu Val Lys 
1               5                   10      


<210>  111
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  111

Val Gly Ala Ile Pro Ala Asn Ala Leu Asp Asp Gly Gln Trp Ser Gln 
1               5                   10                  15      


Gly Leu Ile Ser Ala Ala Arg 
            20              


<210>  112
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Val Ala Ala Ala Thr Asn Asn Leu Cys Glu Ala Ala Asn Ala Ala 
1               5                   10                  15      


Val Gln Gly His Ala Ser Gln Glu Lys 
            20                  25  


<210>  113
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  113

Gln Val Ala Ala Ser Thr Ala Gln Leu Leu Val Ala Cys Lys 
1               5                   10                  


<210>  114
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  114

Ala Asp Gln Asp Ser Glu Ala Met Lys 
1               5                   


<210>  115
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  115

Leu Gln Ala Ala Gly Asn Ala Val Lys 
1               5                   


<210>  116
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  116

Ala Ala Ala Phe Glu Glu Gln Glu Asn Glu Thr Val Val Val Lys 
1               5                   10                  15  


<210>  117
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Val Gly Gly Ile Ala Gln Ile Ile Ala Ala Gln Glu Glu Met Leu 
1               5                   10                  15      


Arg 
    


<210>  118
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  118

Lys Asn Gln Pro Glu Val Asp Met Ser Asp Arg 
1               5                   10      


<210>  119
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  119

Gly Ile Ser Asn Met Leu Asp Val Asn Gly Leu Phe Thr Leu Ser His 
1               5                   10                  15      


Ile Thr Gln Leu Val Leu Ser His Asn Lys 
            20                  25      


<210>  120
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  120

Leu Thr Met Val Pro Pro Asn Ile Ala Glu Leu Lys 
1               5                   10          


<210>  121
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  121

Asn Leu Glu Val Leu Asn Phe Phe Asn Asn Gln Ile Glu Glu Leu Pro 
1               5                   10                  15      


Thr Gln Ile Ser Ser Leu Gln Lys 
            20                  


<210>  122
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  122

His Leu Asn Leu Gly Met Asn Arg 
1               5               


<210>  123
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  123

Gly Phe Gly Ser Leu Pro Ala Leu Glu Val Leu Asp Leu Thr Tyr Asn 
1               5                   10                  15      


Asn Leu Ser Glu Asn Ser Leu Pro Gly Asn Phe Phe Tyr Leu Thr Thr 
            20                  25                  30          


Leu Arg 
        


<210>  124
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  124

Ala Leu Tyr Leu Ser Asp Asn Asp Phe Glu Ile Leu Pro Pro Asp Ile 
1               5                   10                  15      


Gly Lys 
        


<210>  125
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  125

Asp Asn Asp Leu Ile Ser Leu Pro Lys 
1               5                   


<210>  126
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  126

Glu Ile Gly Glu Leu Thr Gln Leu Lys 
1               5                   


<210>  127
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  127

Glu Leu His Ile Gln Gly Asn Arg 
1               5               


<210>  128
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  128

Leu Thr Val Leu Pro Pro Glu Leu Gly Asn Leu Asp Leu Thr Gly Gln 
1               5                   10                  15      


Lys 
    


<210>  129
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  129

Ala Glu Asn Asn Pro Trp Val Thr Pro Ile Ala Asp Gln Phe Gln Leu 
1               5                   10                  15      


Gly Val Ser His Val Phe Glu Tyr Ile Arg 
            20                  25      


<210>  130
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  130

His Met Gln Ala Asn Pro Glu Pro Pro Lys 
1               5                   10  


<210>  131
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  131

Glu Leu Ser Asp Ile Ala His Arg 
1               5               


<210>  132
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  132

Gly Ile Leu Ala Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys 
1               5                   10                  


<210>  133
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  133

Leu Gln Ser Ile Gly Thr Glu Asn Thr Glu Glu Asn Arg 
1               5                   10              


<210>  134
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  134

Gln Leu Leu Leu Thr Ala Asp Asp Arg 
1               5                   


<210>  135
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  135

Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe His Glu Thr Leu Tyr 
1               5                   10                  15      


Gln Lys 
        


<210>  136
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  136

Ala Asp Asp Gly Arg Pro Phe Pro Gln Val Ile Lys 
1               5                   10          


<210>  137
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  137

Gly Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly 
1               5                   10                  15      


Leu Asp Gly Leu Ser Glu Arg 
            20              


<210>  138
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  138

Ile Gly Glu His Thr Pro Ser Ala Leu Ala Ile Met Glu Asn Ala Asn 
1               5                   10                  15      


Val Leu Ala Arg 
            20  


<210>  139
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  139

Tyr Ala Ser Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro 
1               5                   10                  15      


Glu Ile Leu Pro Asp Gly Asp His Asp Leu Lys 
            20                  25          


<210>  140
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  140

Ala Leu Ser Asp His His Ile Tyr Leu Glu Gly Thr Leu Leu Lys Pro 
1               5                   10                  15      


Asn Met Val Thr Pro Gly His Ala Cys Thr Gln Lys 
            20                  25              


<210>  141
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  141

Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala Leu Arg 
1               5                   10                  15  


<210>  142
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  142

Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser Gly Gly Gln 
1               5                   10                  15      


Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn Lys 
            20                  25                  30  


<210>  143
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  143

Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
1               5                   10                  15  


<210>  144
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  144

Ala Leu Gln Ala Ser Ala Leu Lys 
1               5               


<210>  145
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  145

Ala Ala Gln Glu Glu Tyr Val Lys 
1               5               


<210>  146
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  146

Ala Leu Ala Asn Ser Leu Ala Cys Gln Gly Lys 
1               5                   10      


<210>  147
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  147

Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe 
1               5                   10                  15      


Val Ser Asn His Ala Tyr 
            20          


<210>  148
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  148

Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp Ile Phe Glu Leu 
1               5                   10                  15      


Thr Gly Ala Ala Arg 
            20      


<210>  149
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  149

Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg 
1               5                   10  


<210>  150
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  150

Ile Glu Asp Ala Asn Leu Ile Pro Pro Val Pro Asp Asp Lys 
1               5                   10                  


<210>  151
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  151

Phe Gln Asp Leu Val Asp Ala Val Arg 
1               5                   


<210>  152
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  152

Gly Phe Leu Leu Leu Ala Ser Leu Arg 
1               5                   


<210>  153
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  153

Gly Thr Leu Leu Ala Leu Glu Arg 
1               5               


<210>  154
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  154

Asp His Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys 
1               5                   10                  


<210>  155
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  155

Ala Gly Thr Leu Asp Leu Ser Leu Thr Val Gln Gly Lys 
1               5                   10              


<210>  156
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  156

Gln His Val Val Ser Val Glu Glu Ala Leu Leu Ala Thr Gly Gln Trp 
1               5                   10                  15      


Lys 
    


<210>  157
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  157

Ser Ile Thr Leu Phe Val Gln Glu Asp Arg 
1               5                   10  


<210>  158
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  158

Ala Gln Leu Tyr Ile Asp Cys Glu Lys 
1               5                   


<210>  159
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Glu Asn Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg 
1               5                   10                  15      


<210>  160
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  160

Gly Gly Val Asn Asp Asn Phe Gln Gly Val Leu Gln Asn Val Arg 
1               5                   10                  15  


<210>  161
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  161

Phe Val Phe Gly Thr Thr Pro Glu Asp Ile Leu Arg 
1               5                   10          


<210>  162
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  162

Gly Cys Ser Ser Ser Thr Ser Val Leu Leu Thr Leu Asp Asn Asn Val 
1               5                   10                  15      


Val Asn Gly Ser Ser Pro Ala Ile Arg 
            20                  25  


<210>  163
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  163

Asp Leu Gln Ala Ile Cys Gly Ile Ser Cys Asp Glu Leu Ser Ser Met 
1               5                   10                  15      


Val Leu Glu Leu Arg 
            20      


<210>  164
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  164

Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg 
1               5                   10      


<210>  165
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  165

Arg Pro Pro Leu Cys Tyr His Asn Gly Val Gln Tyr Arg 
1               5                   10              


<210>  166
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  166

Asn Asn Glu Glu Trp Thr Val Asp Ser Cys Thr Glu Cys His Cys Gln 
1               5                   10                  15      


Asn Ser Val Thr Ile Cys Lys 
            20              


<210>  167
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  167

Val Ser Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly 
1               5                   10                  15      


Glu Cys Cys Pro Arg 
            20      


<210>  168
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  168

Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro Trp Ser Glu 
1               5                   10                  15      


Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln Gln Arg 
            20                  25                  30      


<210>  169
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  169

Ser Cys Asp Ser Leu Asn Asn Arg 
1               5               


<210>  170
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  170

Cys Glu Gly Ser Ser Val Gln Thr Arg 
1               5                   


<210>  171
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  171

Thr Cys His Ile Gln Glu Cys Asp Lys 
1               5                   


<210>  172
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  172

Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser Val 
1               5                   10                  15      


Thr Cys Gly Asp Gly Val Ile Thr Arg 
            20                  25  


<210>  173
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  173

Leu Cys Asn Ser Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly 
1               5                   10                  15      


Glu Ala Arg 
            


<210>  174
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  174

Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly Pro Trp Ser Pro Trp Asp 
1               5                   10                  15      


Ile Cys Ser Val Thr Cys Gly Gly Gly Val Gln Lys 
            20                  25              


<210>  175
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  175

Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly Lys 
1               5                   10          


<210>  176
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  176

Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys 
1               5                   10                  


<210>  177
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  177

Gln Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly 
1               5                   10                  15      


Val Lys 
        


<210>  178
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  178

Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys 
1               5                   10  


<210>  179
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  179

Cys Gly Ala Cys Pro Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr 
1               5                   10                  15      


Asp Val Asp Glu Cys Lys 
            20          


<210>  180
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  180

Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg 
1               5                   10                  


<210>  181
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  181

Cys Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg 
1               5                   10                  15      


<210>  182
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  182

Phe Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala 
1               5                   10                  15      


Asn Lys 
        


<210>  183
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  183

Asn Pro Cys Thr Asp Gly Thr His Asp Cys Asn Lys 
1               5                   10          


<210>  184
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  184

Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro Met Tyr Arg 
1               5                   10              


<210>  185
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  185

Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile Cys Gly Glu 
1               5                   10                  15      


Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val Cys Val Ala 
            20                  25                  30          


Asn Ala Thr Tyr His Cys Lys 
        35                  


<210>  186
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  186

Asp Asn Cys Pro Asn Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys 
1               5                   10                  15      


<210>  187
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  187

Asp Gly Ile Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys 
1               5                   10                  15  


<210>  188
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  188

Asp Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg 
1               5                   10                  15      


<210>  189
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  189

Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp Gln Ala Asp Thr Asp 
1               5                   10                  15      


Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp Ile Asp Gly Asp Gly 
            20                  25                  30          


Ile Leu Asn Glu Arg 
        35          


<210>  190
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  190

Asp Asn Cys Gln Tyr Val Tyr Asn Val Asp Gln Arg 
1               5                   10          


<210>  191
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  191

Asp Thr Asp Met Asp Gly Val Gly Asp Gln Cys Asp Asn Cys Pro Leu 
1               5                   10                  15      


Glu His Asn Pro Asp Gln Leu Asp Ser Asp Ser Asp Arg 
            20                  25                  


<210>  192
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  192

Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu Asp Gly His 
1               5                   10                  15      


Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala Asn Gln Ala 
            20                  25                  30          


Asp His Asp Lys 
        35      


<210>  193
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  193

Gly Asp Ala Cys Asp His Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp 
1               5                   10                  15      


Lys 
    


<210>  194
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  194

Leu Val Pro Asn Pro Asp Gln Lys 
1               5               


<210>  195
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  195

Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp Ile Cys Pro 
1               5                   10                  15      


Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg 
            20                  25          


<210>  196
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  196

Phe Gln Met Ile Pro Leu Asp Pro Lys 
1               5                   


<210>  197
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  197

Gly Thr Ser Gln Asn Asp Pro Asn Trp Val Val Arg 
1               5                   10          


<210>  198
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  198

Glu Leu Val Gln Thr Val Asn Cys Asp Pro Gly Leu Ala Val Gly Tyr 
1               5                   10                  15      


Asp Glu Phe Asn Ala Val Asp Phe Ser Gly Thr Phe Phe Ile Asn Thr 
            20                  25                  30          


Glu Arg 
        


<210>  199
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  199

Asp Asp Asp Tyr Ala Gly Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg 
1               5                   10                  15      


<210>  200
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  200

Gln Val Thr Gln Ser Tyr Trp Asp Thr Asn Pro Thr Arg 
1               5                   10              


<210>  201
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  201

Ala Gln Gly Tyr Ser Gly Leu Ser Val Lys 
1               5                   10  


<210>  202
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  202

Val Val Asn Ser Thr Thr Gly Pro Gly Glu His Leu Arg 
1               5                   10              


<210>  203
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  203

Asn Ala Leu Trp His Thr Gly Asn Thr Pro Gly Gln Val Arg 
1               5                   10                  


<210>  204
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  204

Ile Met Ala Asp Ser Gly Pro Ile Tyr Asp Lys 
1               5                   10      


<210>  205
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  205

Leu Gly Leu Phe Val Phe Ser Gln Glu Met Val Phe Phe Ser Asp Leu 
1               5                   10                  15      


Lys 
    


<210>  206
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  206

Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp Ala Gln Gly 
1               5                   10                  15      


Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly Lys 
            20                  25                  30  


<210>  207
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  207

Thr Val Leu Thr Pro Ala Thr Asn His Met Gly Asn Val Thr Phe Thr 
1               5                   10                  15      


Ile Pro Ala Asn Arg 
            20      


<210>  208
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  208

Phe Val Thr Val Gln Ala Thr Phe Gly Thr Gln Val Val Glu Lys 
1               5                   10                  15  


<210>  209
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  209

Val Val Leu Val Ser Leu Gln Ser Gly Tyr Leu Phe Ile Gln Thr Asp 
1               5                   10                  15      


Lys 
    


<210>  210
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  210

Thr Ile Tyr Thr Pro Gly Ser Thr Val Leu Tyr Arg 
1               5                   10          


<210>  211
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  211

Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
1               5                   10                  15  


<210>  212
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  212

Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
1               5                   10                  15      


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys 
            20                  25                  


<210>  213
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  213

Ala Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu 
1               5                   10                  15      


Val Lys 
        


<210>  214
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  214

Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu Lys 
1               5                   10                  15      


<210>  215
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  215

Phe Tyr Tyr Ile Tyr Asn Glu Lys 
1               5               


<210>  216
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  216

Gly Leu Glu Val Thr Ile Thr Ala Arg 
1               5                   


<210>  217
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  217

Val Glu Gly Thr Ala Phe Val Ile Phe Gly Ile Gln Asp Gly Glu Gln 
1               5                   10                  15      


Arg 
    


<210>  218
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  218

Ile Ser Leu Pro Glu Ser Leu Lys 
1               5               


<210>  219
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  219

Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
1               5                   10                  


<210>  220
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  220

Val Leu Leu Asp Gly Val Gln Asn Pro Arg 
1               5                   10  


<210>  221
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  221

Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser Asp Met 
1               5                   10                  15      


Val Gln Ala Glu Arg 
            20      


<210>  222
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  222

Ser Gly Ile Pro Ile Val Thr Ser Pro Tyr Gln Ile His Phe Thr Lys 
1               5                   10                  15      


<210>  223
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  223

Tyr Phe Lys Pro Gly Met Pro Phe Asp Leu Met Val Phe Val Thr Asn 
1               5                   10                  15      


Pro Asp Gly Ser Pro Ala Tyr Arg 
            20                  


<210>  224
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  224

Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu Thr Gln 
1               5                   10                  15      


Gly Asp Gly Val Ala Lys 
            20          


<210>  225
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  225

Leu Ser Ile Asn Thr His Pro Ser Gln Lys Pro Leu Ser Ile Thr Val 
1               5                   10                  15      


Arg 
    


<210>  226
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  226

Gln Glu Leu Ser Glu Ala Glu Gln Ala Thr Arg 
1               5                   10      


<210>  227
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  227

Thr Met Gln Ala Leu Pro Tyr Ser Thr Val Gly Asn Ser Asn Asn Tyr 
1               5                   10                  15      


Leu His Leu Ser Val Leu Arg 
            20              


<210>  228
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  228

Thr Glu Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg 
1               5                   10                  15      


<210>  229
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  229

Tyr Tyr Thr Tyr Leu Ile Met Asn Lys 
1               5                   


<210>  230
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  230

Glu Pro Gly Gln Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp 
1               5                   10                  15      


Phe Ile Pro Ser Phe Arg 
            20          


<210>  231
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  231

Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
1               5                   10                  


<210>  232
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  232

Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys 
1               5                   10          


<210>  233
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  233

Asp Ser Cys Val Gly Ser Leu Val Val Lys 
1               5                   10  


<210>  234
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  234

Gln Pro Val Pro Gly Gln Gln Met Thr Leu Lys 
1               5                   10      


<210>  235
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  235

Ile Glu Gly Asp His Gly Ala Arg 
1               5               


<210>  236
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  236

Val Val Leu Val Ala Val Asp Lys 
1               5               


<210>  237
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  237

Ala Asp Ile Gly Cys Thr Pro Gly Ser Gly Lys 
1               5                   10      


<210>  238
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  238

Asp Tyr Ala Gly Val Phe Ser Asp Ala Gly Leu Thr Phe Thr Ser Ser 
1               5                   10                  15      


Ser Gly Gln Gln Thr Ala Gln Arg 
            20                  


<210>  239
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  239

Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg 
1               5                   10      


<210>  240
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  240

Phe Ile Ser Leu Gly Glu Ala Cys Lys 
1               5                   


<210>  241
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  241

Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg 
1               5                   10              


<210>  242
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  242

Ala Ser His Leu Gly Leu Ala Arg 
1               5               


<210>  243
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  243

Ser Asn Leu Asp Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg 
1               5                   10                  15      


<210>  244
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  244

Ser Glu Phe Pro Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys 
1               5                   10                  15  


<210>  245
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  245

Asp Ser Ile Thr Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys 
1               5                   10                  15      


<210>  246
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  246

Gly Ile Cys Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe 
1               5                   10                  15      


Phe Ile Asp Leu Arg 
            20      


<210>  247
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  247

Val Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys 
1               5                   10                  15      


<210>  248
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  248

His Gln Gln Thr Val Thr Ile Pro Pro Lys 
1               5                   10  


<210>  249
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  249

Ser Ser Leu Ser Val Pro Tyr Val Ile Val Pro Leu Lys 
1               5                   10              


<210>  250
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  250

Thr Gly Leu Gln Glu Val Glu Val Lys 
1               5                   


<210>  251
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  251

Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg 
1               5                   10              


<210>  252
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  252

Glu Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu 
1               5                   10                  15      


Ser Glu Thr Arg 
            20  


<210>  253
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  253

Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu Asp Ala Val 
1               5                   10                  15      


Asp Ala Glu Arg 
            20  


<210>  254
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  254

His Leu Ile Val Thr Pro Ser Gly Cys Gly Glu Gln Asn Met Ile Gly 
1               5                   10                  15      


Met Thr Pro Thr Val Ile Ala Val His Tyr Leu Asp Glu Thr Glu Gln 
            20                  25                  30          


Trp Glu Lys 
        35  


<210>  255
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  255

Gln Gly Ala Leu Glu Leu Ile Lys 
1               5               


<210>  256
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  256

Gly Tyr Thr Gln Gln Leu Ala Phe Arg 
1               5                   


<210>  257
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  257

Gln Pro Ser Ser Ala Phe Ala Ala Phe Val Lys 
1               5                   10      


<210>  258
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  258

Ala Pro Ser Thr Trp Leu Thr Ala Tyr Val Val Lys 
1               5                   10          


<210>  259
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  259

Val Phe Ser Leu Ala Val Asn Leu Ile Ala Ile Asp Ser Gln Val Leu 
1               5                   10                  15      


Cys Gly Ala Val Lys 
            20      


<210>  260
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  260

Gln Lys Pro Asp Gly Val Phe Gln Glu Asp Ala Pro Val Ile His Gln 
1               5                   10                  15      


Glu Met Ile Gly Gly Leu Arg 
            20              


<210>  261
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  261

Asp Met Ala Leu Thr Ala Phe Val Leu Ile Ser Leu Gln Glu Ala Lys 
1               5                   10                  15      


<210>  262
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  262

Asp Ile Cys Glu Glu Gln Val Asn Ser Leu Pro Gly Ser Ile Thr Lys 
1               5                   10                  15      


<210>  263
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  263

Ala Gly Asp Phe Leu Glu Ala Asn Tyr Met Asn Leu Gln Arg 
1               5                   10                  


<210>  264
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  264

Ser Tyr Thr Val Ala Ile Ala Gly Tyr Ala Leu Ala Gln Met Gly Arg 
1               5                   10                  15      


<210>  265
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  265

Gln Leu Tyr Asn Val Glu Ala Thr Ser Tyr Ala Leu Leu Ala Leu Leu 
1               5                   10                  15      


Gln Leu Lys 
            


<210>  266
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  266

Asp Phe Asp Phe Val Pro Pro Val Val Arg 
1               5                   10  


<210>  267
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  267

Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe Met Val Phe 
1               5                   10                  15      


Gln Ala Leu Ala Gln Tyr Gln Lys 
            20                  


<210>  268
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  268

Asp Ala Pro Asp His Gln Glu Leu Asn Leu Asp Val Ser Leu Gln Leu 
1               5                   10                  15      


Pro Ser Arg 
            


<210>  269
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  269

Ile His Trp Glu Ser Ala Ser Leu Leu Arg 
1               5                   10  


<210>  270
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  270

Glu Asn Glu Gly Phe Thr Val Thr Ala Glu Gly Lys 
1               5                   10          


<210>  271
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  271

Gly Gln Gly Thr Leu Ser Val Val Thr Met Tyr His Ala Lys 
1               5                   10                  


<210>  272
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  272

Val Thr Ile Lys Pro Ala Pro Glu Thr Glu Lys 
1               5                   10      


<210>  273
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  273

Asn Thr Met Ile Leu Glu Ile Cys Thr Arg 
1               5                   10  


<210>  274
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  274

Gly Asp Gln Asp Ala Thr Met Ser Ile Leu Asp Ile Ser Met Met Thr 
1               5                   10                  15      


Gly Phe Ala Pro Asp Thr Asp Asp Leu Lys 
            20                  25      


<210>  275
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  275

Gln Leu Ala Asn Gly Val Asp Arg 
1               5               


<210>  276
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  276

Asn Thr Leu Ile Ile Tyr Leu Asp Lys 
1               5                   


<210>  277
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  277

Val Ser His Ser Glu Asp Asp Cys Leu Ala Phe Lys 
1               5                   10          


<210>  278
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  278

Val His Gln Tyr Phe Asn Val Glu Leu Ile Gln Pro Gly Ala Val Lys 
1               5                   10                  15      


<210>  279
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  279

Val Tyr Ala Tyr Tyr Asn Leu Glu Glu Ser Cys Thr Arg 
1               5                   10              


<210>  280
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  280

Cys Ala Glu Glu Asn Cys Phe Ile Gln Lys 
1               5                   10  


<210>  281
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  281

Ala Cys Glu Pro Gly Val Asp Tyr Val Tyr Lys 
1               5                   10      


<210>  282
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  282

Val Gln Leu Ser Asn Asp Phe Asp Glu Tyr Ile Met Ala Ile Glu Gln 
1               5                   10                  15      


Thr Ile Lys 
            


<210>  283
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  283

Ser Gly Ser Asp Glu Val Gln Val Gly Gln Gln Arg 
1               5                   10          


<210>  284
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  284

His Tyr Leu Met Trp Gly Leu Ser Ser Asp Phe Trp Gly Glu Lys Pro 
1               5                   10                  15      


Asn Leu Ser Tyr Ile Ile Gly Lys 
            20                  


<210>  285
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  285

Asp Thr Trp Val Glu His Trp Pro Glu Glu Asp Glu Cys Gln Asp Glu 
1               5                   10                  15      


Glu Asn Gln Lys 
            20  


<210>  286
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  286

Gln Cys Gln Asp Leu Gly Ala Phe Thr Glu Ser Met Val Val Phe Gly 
1               5                   10                  15      


Cys Pro Asn 
            


<210>  287
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  287

Gly Ser Ala Pro Pro Gly Pro Val Pro Glu Gly Ser Ile Arg 
1               5                   10                  


<210>  288
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  288

His Glu Val Ile Asn Ile Asn Leu Lys 
1               5                   


<210>  289
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  289

Asn Lys Pro Glu Trp Phe Phe Lys 
1               5               


<210>  290
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  290

Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly Gln Leu 
1               5                   10                  15      


Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala Tyr Pro 
            20                  25                  30          


Gly Lys 
        


<210>  291
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  291

Leu Leu Pro Asp Asp Pro Tyr Glu Lys 
1               5                   


<210>  292
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Ile Leu Glu Leu Phe Ser Lys 
1               5               


<210>  293
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  293

Val Pro Ser Leu Val Gly Ser Phe Ile Arg 
1               5                   10  


<210>  294
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  294

Leu Glu Glu Val Leu Thr Asn Lys 
1               5               


<210>  295
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  295

Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu Ile 
1               5                   10                  15      


Trp Pro Trp Phe Glu Arg 
            20          


<210>  296
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  296

Leu Asn Glu Cys Val Asp His Thr Pro Lys 
1               5                   10  


<210>  297
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  297

Glu Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys 
1               5                   10              


<210>  298
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  298

Asp Trp Gln Gly Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala 
1               5                   10                  15      


Cys Asp Tyr Gly Leu 
            20      


<210>  299
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  300
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  301
<211>  2541
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr 
1               5                   10                  15      


Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile 
            20                  25                  30          


Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly 
        35                  40                  45              


Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 
    50                  55                  60                  


Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 
65                  70                  75                  80  


Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr 
                85                  90                  95      


Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu 
            100                 105                 110         


Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser 
        115                 120                 125             


Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr 
    130                 135                 140                 


Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 
145                 150                 155                 160 


Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 
                165                 170                 175     


Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 
            180                 185                 190         


Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 
        195                 200                 205             


Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu 
    210                 215                 220                 


Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 
225                 230                 235                 240 


Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys 
                245                 250                 255     


Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys 
            260                 265                 270         


Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln 
        275                 280                 285             


Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 
    290                 295                 300                 


Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 
305                 310                 315                 320 


Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys 
                325                 330                 335     


Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn 
            340                 345                 350         


Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu 
        355                 360                 365             


Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu 
    370                 375                 380                 


Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu 
385                 390                 395                 400 


Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 
                405                 410                 415     


Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 
            420                 425                 430         


Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 
        435                 440                 445             


Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln 
    450                 455                 460                 


Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met 
465                 470                 475                 480 


His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr 
                485                 490                 495     


Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr 
            500                 505                 510         


Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser 
        515                 520                 525             


Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His 
    530                 535                 540                 


Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 
545                 550                 555                 560 


Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 
                565                 570                 575     


Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys 
            580                 585                 590         


Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu 
        595                 600                 605             


Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
    610                 615                 620                 


Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala 
625                 630                 635                 640 


Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 
                645                 650                 655     


Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala 
            660                 665                 670         


Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 
        675                 680                 685             


Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 
    690                 695                 700                 


Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr 
705                 710                 715                 720 


Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu 
                725                 730                 735     


Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser 
            740                 745                 750         


Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly 
        755                 760                 765             


Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His 
    770                 775                 780                 


Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 
785                 790                 795                 800 


Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 
                805                 810                 815     


Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala 
            820                 825                 830         


Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser 
        835                 840                 845             


Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala 
    850                 855                 860                 


Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 
865                 870                 875                 880 


Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly 
                885                 890                 895     


Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 
            900                 905                 910         


Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 
        915                 920                 925             


Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala 
    930                 935                 940                 


Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala 
945                 950                 955                 960 


Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln 
                965                 970                 975     


Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 
            980                 985                 990         


Phe Leu Gln Pro Gly Gly Lys Met  Val Ala Ala Ala Lys  Ala Ser Val 
        995                 1000                 1005             


Pro Thr  Ile Gln Asp Gln Ala  Ser Ala Met Gln Leu  Ser Gln Cys 
    1010                 1015                 1020             


Ala Lys  Asn Leu Gly Thr Ala  Leu Ala Glu Leu Arg  Thr Ala Ala 
    1025                 1030                 1035             


Gln Lys  Ala Gln Glu Ala Cys  Gly Pro Leu Glu Met  Asp Ser Ala 
    1040                 1045                 1050             


Leu Ser  Val Val Gln Asn Leu  Glu Lys Asp Leu Gln  Glu Val Lys 
    1055                 1060                 1065             


Ala Ala  Ala Arg Asp Gly Lys  Leu Lys Pro Leu Pro  Gly Glu Thr 
    1070                 1075                 1080             


Met Glu  Lys Cys Thr Gln Asp  Leu Gly Asn Ser Thr  Lys Ala Val 
    1085                 1090                 1095             


Ser Ser  Ala Ile Ala Gln Leu  Leu Gly Glu Val Ala  Gln Gly Asn 
    1100                 1105                 1110             


Glu Asn  Tyr Ala Gly Ile Ala  Ala Arg Asp Val Ala  Gly Gly Leu 
    1115                 1120                 1125             


Arg Ser  Leu Ala Gln Ala Ala  Arg Gly Val Ala Ala  Leu Thr Ser 
    1130                 1135                 1140             


Asp Pro  Ala Val Gln Ala Ile  Val Leu Asp Thr Ala  Ser Asp Val 
    1145                 1150                 1155             


Leu Asp  Lys Ala Ser Ser Leu  Ile Glu Glu Ala Lys  Lys Ala Ala 
    1160                 1165                 1170             


Gly His  Pro Gly Asp Pro Glu  Ser Gln Gln Arg Leu  Ala Gln Val 
    1175                 1180                 1185             


Ala Lys  Ala Val Thr Gln Ala  Leu Asn Arg Cys Val  Ser Cys Leu 
    1190                 1195                 1200             


Pro Gly  Gln Arg Asp Val Asp  Asn Ala Leu Arg Ala  Val Gly Asp 
    1205                 1210                 1215             


Ala Ser  Lys Arg Leu Leu Ser  Asp Ser Leu Pro Pro  Ser Thr Gly 
    1220                 1225                 1230             


Thr Phe  Gln Glu Ala Gln Ser  Arg Leu Asn Glu Ala  Ala Ala Gly 
    1235                 1240                 1245             


Leu Asn  Gln Ala Ala Thr Glu  Leu Val Gln Ala Ser  Arg Gly Thr 
    1250                 1255                 1260             


Pro Gln  Asp Leu Ala Arg Ala  Ser Gly Arg Phe Gly  Gln Asp Phe 
    1265                 1270                 1275             


Ser Thr  Phe Leu Glu Ala Gly  Val Glu Met Ala Gly  Gln Ala Pro 
    1280                 1285                 1290             


Ser Gln  Glu Asp Arg Ala Gln  Val Val Ser Asn Leu  Lys Gly Ile 
    1295                 1300                 1305             


Ser Met  Ser Ser Ser Lys Leu  Leu Leu Ala Ala Lys  Ala Leu Ser 
    1310                 1315                 1320             


Thr Asp  Pro Ala Ala Pro Asn  Leu Lys Ser Gln Leu  Ala Ala Ala 
    1325                 1330                 1335             


Ala Arg  Ala Val Thr Asp Ser  Ile Asn Gln Leu Ile  Thr Met Cys 
    1340                 1345                 1350             


Thr Gln  Gln Ala Pro Gly Gln  Lys Glu Cys Asp Asn  Ala Leu Arg 
    1355                 1360                 1365             


Glu Leu  Glu Thr Val Arg Glu  Leu Leu Glu Asn Pro  Val Gln Pro 
    1370                 1375                 1380             


Ile Asn  Asp Met Ser Tyr Phe  Gly Cys Leu Asp Ser  Val Met Glu 
    1385                 1390                 1395             


Asn Ser  Lys Val Leu Gly Glu  Ala Met Thr Gly Ile  Ser Gln Asn 
    1400                 1405                 1410             


Ala Lys  Asn Gly Asn Leu Pro  Glu Phe Gly Asp Ala  Ile Ser Thr 
    1415                 1420                 1425             


Ala Ser  Lys Ala Leu Cys Gly  Phe Thr Glu Ala Ala  Ala Gln Ala 
    1430                 1435                 1440             


Ala Tyr  Leu Val Gly Val Ser  Asp Pro Asn Ser Gln  Ala Gly Gln 
    1445                 1450                 1455             


Gln Gly  Leu Val Glu Pro Thr  Gln Phe Ala Arg Ala  Asn Gln Ala 
    1460                 1465                 1470             


Ile Gln  Met Ala Cys Gln Ser  Leu Gly Glu Pro Gly  Cys Thr Gln 
    1475                 1480                 1485             


Ala Gln  Val Leu Ser Ala Ala  Thr Ile Val Ala Lys  His Thr Ser 
    1490                 1495                 1500             


Ala Leu  Cys Asn Ser Cys Arg  Leu Ala Ser Ala Arg  Thr Thr Asn 
    1505                 1510                 1515             


Pro Thr  Ala Lys Arg Gln Phe  Val Gln Ser Ala Lys  Glu Val Ala 
    1520                 1525                 1530             


Asn Ser  Thr Ala Asn Leu Val  Lys Thr Ile Lys Ala  Leu Asp Gly 
    1535                 1540                 1545             


Ala Phe  Thr Glu Glu Asn Arg  Ala Gln Cys Arg Ala  Ala Thr Ala 
    1550                 1555                 1560             


Pro Leu  Leu Glu Ala Val Asp  Asn Leu Ser Ala Phe  Ala Ser Asn 
    1565                 1570                 1575             


Pro Glu  Phe Ser Ser Ile Pro  Ala Gln Ile Ser Pro  Glu Gly Arg 
    1580                 1585                 1590             


Ala Ala  Met Glu Pro Ile Val  Ile Ser Ala Lys Thr  Met Leu Glu 
    1595                 1600                 1605             


Ser Ala  Gly Gly Leu Ile Gln  Thr Ala Arg Ala Leu  Ala Val Asn 
    1610                 1615                 1620             


Pro Arg  Asp Pro Pro Ser Trp  Ser Val Leu Ala Gly  His Ser Arg 
    1625                 1630                 1635             


Thr Val  Ser Asp Ser Ile Lys  Lys Leu Ile Thr Ser  Met Arg Asp 
    1640                 1645                 1650             


Lys Ala  Pro Gly Gln Leu Glu  Cys Glu Thr Ala Ile  Ala Ala Leu 
    1655                 1660                 1665             


Asn Ser  Cys Leu Arg Asp Leu  Asp Gln Ala Ser Leu  Ala Ala Val 
    1670                 1675                 1680             


Ser Gln  Gln Leu Ala Pro Arg  Glu Gly Ile Ser Gln  Glu Ala Leu 
    1685                 1690                 1695             


His Thr  Gln Met Leu Thr Ala  Val Gln Glu Ile Ser  His Leu Ile 
    1700                 1705                 1710             


Glu Pro  Leu Ala Asn Ala Ala  Arg Ala Glu Ala Ser  Gln Leu Gly 
    1715                 1720                 1725             


His Lys  Val Ser Gln Met Ala  Gln Tyr Phe Glu Pro  Leu Thr Leu 
    1730                 1735                 1740             


Ala Ala  Val Gly Ala Ala Ser  Lys Thr Leu Ser His  Pro Gln Gln 
    1745                 1750                 1755             


Met Ala  Leu Leu Asp Gln Thr  Lys Thr Leu Ala Glu  Ser Ala Leu 
    1760                 1765                 1770             


Gln Leu  Leu Tyr Thr Ala Lys  Glu Ala Gly Gly Asn  Pro Lys Gln 
    1775                 1780                 1785             


Ala Ala  His Thr Gln Glu Ala  Leu Glu Glu Ala Val  Gln Met Met 
    1790                 1795                 1800             


Thr Glu  Ala Val Glu Asp Leu  Thr Thr Thr Leu Asn  Glu Ala Ala 
    1805                 1810                 1815             


Ser Ala  Ala Gly Val Val Gly  Gly Met Val Asp Ser  Ile Thr Gln 
    1820                 1825                 1830             


Ala Ile  Asn Gln Leu Asp Glu  Gly Pro Met Gly Glu  Pro Glu Gly 
    1835                 1840                 1845             


Ser Phe  Val Asp Tyr Gln Thr  Thr Met Val Arg Thr  Ala Lys Ala 
    1850                 1855                 1860             


Ile Ala  Val Thr Val Gln Glu  Met Val Thr Lys Ser  Asn Thr Ser 
    1865                 1870                 1875             


Pro Glu  Glu Leu Gly Pro Leu  Ala Asn Gln Leu Thr  Ser Asp Tyr 
    1880                 1885                 1890             


Gly Arg  Leu Ala Ser Glu Ala  Lys Pro Ala Ala Val  Ala Ala Glu 
    1895                 1900                 1905             


Asn Glu  Glu Ile Gly Ser His  Ile Lys His Arg Val  Gln Glu Leu 
    1910                 1915                 1920             


Gly His  Gly Cys Ala Ala Leu  Val Thr Lys Ala Gly  Ala Leu Gln 
    1925                 1930                 1935             


Cys Ser  Pro Ser Asp Ala Tyr  Thr Lys Lys Glu Leu  Ile Glu Cys 
    1940                 1945                 1950             


Ala Arg  Arg Val Ser Glu Lys  Val Ser His Val Leu  Ala Ala Leu 
    1955                 1960                 1965             


Gln Ala  Gly Asn Arg Gly Thr  Gln Ala Cys Ile Thr  Ala Ala Ser 
    1970                 1975                 1980             


Ala Val  Ser Gly Ile Ile Ala  Asp Leu Asp Thr Thr  Ile Met Phe 
    1985                 1990                 1995             


Ala Thr  Ala Gly Thr Leu Asn  Arg Glu Gly Thr Glu  Thr Phe Ala 
    2000                 2005                 2010             


Asp His  Arg Glu Gly Ile Leu  Lys Thr Ala Lys Val  Leu Val Glu 
    2015                 2020                 2025             


Asp Thr  Lys Val Leu Val Gln  Asn Ala Ala Gly Ser  Gln Glu Lys 
    2030                 2035                 2040             


Leu Ala  Gln Ala Ala Gln Ser  Ser Val Ala Thr Ile  Thr Arg Leu 
    2045                 2050                 2055             


Ala Asp  Val Val Lys Leu Gly  Ala Ala Ser Leu Gly  Ala Glu Asp 
    2060                 2065                 2070             


Pro Glu  Thr Gln Val Val Leu  Ile Asn Ala Val Lys  Asp Val Ala 
    2075                 2080                 2085             


Lys Ala  Leu Gly Asp Leu Ile  Ser Ala Thr Lys Ala  Ala Ala Gly 
    2090                 2095                 2100             


Lys Val  Gly Asp Asp Pro Ala  Val Trp Gln Leu Lys  Asn Ser Ala 
    2105                 2110                 2115             


Lys Val  Met Val Thr Asn Val  Thr Ser Leu Leu Lys  Thr Val Lys 
    2120                 2125                 2130             


Ala Val  Glu Asp Glu Ala Thr  Lys Gly Thr Arg Ala  Leu Glu Ala 
    2135                 2140                 2145             


Thr Thr  Glu His Ile Arg Gln  Glu Leu Ala Val Phe  Cys Ser Pro 
    2150                 2155                 2160             


Glu Pro  Pro Ala Lys Thr Ser  Thr Pro Glu Asp Phe  Ile Arg Met 
    2165                 2170                 2175             


Thr Lys  Gly Ile Thr Met Ala  Thr Ala Lys Ala Val  Ala Ala Gly 
    2180                 2185                 2190             


Asn Ser  Cys Arg Gln Glu Asp  Val Ile Ala Thr Ala  Asn Leu Ser 
    2195                 2200                 2205             


Arg Arg  Ala Ile Ala Asp Met  Leu Arg Ala Cys Lys  Glu Ala Ala 
    2210                 2215                 2220             


Tyr His  Pro Glu Val Ala Pro  Asp Val Arg Leu Arg  Ala Leu His 
    2225                 2230                 2235             


Tyr Gly  Arg Glu Cys Ala Asn  Gly Tyr Leu Glu Leu  Leu Asp His 
    2240                 2245                 2250             


Val Leu  Leu Thr Leu Gln Lys  Pro Ser Pro Glu Leu  Lys Gln Gln 
    2255                 2260                 2265             


Leu Thr  Gly His Ser Lys Arg  Val Ala Gly Ser Val  Thr Glu Leu 
    2270                 2275                 2280             


Ile Gln  Ala Ala Glu Ala Met  Lys Gly Thr Glu Trp  Val Asp Pro 
    2285                 2290                 2295             


Glu Asp  Pro Thr Val Ile Ala  Glu Asn Glu Leu Leu  Gly Ala Ala 
    2300                 2305                 2310             


Ala Ala  Ile Glu Ala Ala Ala  Lys Lys Leu Glu Gln  Leu Lys Pro 
    2315                 2320                 2325             


Arg Ala  Lys Pro Lys Glu Ala  Asp Glu Ser Leu Asn  Phe Glu Glu 
    2330                 2335                 2340             


Gln Ile  Leu Glu Ala Ala Lys  Ser Ile Ala Ala Ala  Thr Ser Ala 
    2345                 2350                 2355             


Leu Val  Lys Ala Ala Ser Ala  Ala Gln Arg Glu Leu  Val Ala Gln 
    2360                 2365                 2370             


Gly Lys  Val Gly Ala Ile Pro  Ala Asn Ala Leu Asp  Asp Gly Gln 
    2375                 2380                 2385             


Trp Ser  Gln Gly Leu Ile Ser  Ala Ala Arg Met Val  Ala Ala Ala 
    2390                 2395                 2400             


Thr Asn  Asn Leu Cys Glu Ala  Ala Asn Ala Ala Val  Gln Gly His 
    2405                 2410                 2415             


Ala Ser  Gln Glu Lys Leu Ile  Ser Ser Ala Lys Gln  Val Ala Ala 
    2420                 2425                 2430             


Ser Thr  Ala Gln Leu Leu Val  Ala Cys Lys Val Lys  Ala Asp Gln 
    2435                 2440                 2445             


Asp Ser  Glu Ala Met Lys Arg  Leu Gln Ala Ala Gly  Asn Ala Val 
    2450                 2455                 2460             


Lys Arg  Ala Ser Asp Asn Leu  Val Lys Ala Ala Gln  Lys Ala Ala 
    2465                 2470                 2475             


Ala Phe  Glu Glu Gln Glu Asn  Glu Thr Val Val Val  Lys Glu Lys 
    2480                 2485                 2490             


Met Val  Gly Gly Ile Ala Gln  Ile Ile Ala Ala Gln  Glu Glu Met 
    2495                 2500                 2505             


Leu Arg  Lys Glu Arg Glu Leu  Glu Glu Ala Arg Lys  Lys Leu Ala 
    2510                 2515                 2520             


Gln Ile  Arg Gln Gln Gln Tyr  Lys Phe Leu Pro Ser  Glu Leu Arg 
    2525                 2530                 2535             


Asp Glu  His 
    2540     


<210>  302
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Ser Lys Ser Leu Lys Lys Leu Val Glu Glu Ser Arg Glu Lys Asn 
1               5                   10                  15      


Gln Pro Glu Val Asp Met Ser Asp Arg Gly Ile Ser Asn Met Leu Asp 
            20                  25                  30          


Val Asn Gly Leu Phe Thr Leu Ser His Ile Thr Gln Leu Val Leu Ser 
        35                  40                  45              


His Asn Lys Leu Thr Met Val Pro Pro Asn Ile Ala Glu Leu Lys Asn 
    50                  55                  60                  


Leu Glu Val Leu Asn Phe Phe Asn Asn Gln Ile Glu Glu Leu Pro Thr 
65                  70                  75                  80  


Gln Ile Ser Ser Leu Gln Lys Leu Lys His Leu Asn Leu Gly Met Asn 
                85                  90                  95      


Arg Leu Asn Thr Leu Pro Arg Gly Phe Gly Ser Leu Pro Ala Leu Glu 
            100                 105                 110         


Val Leu Asp Leu Thr Tyr Asn Asn Leu Ser Glu Asn Ser Leu Pro Gly 
        115                 120                 125             


Asn Phe Phe Tyr Leu Thr Thr Leu Arg Ala Leu Tyr Leu Ser Asp Asn 
    130                 135                 140                 


Asp Phe Glu Ile Leu Pro Pro Asp Ile Gly Lys Leu Thr Lys Leu Gln 
145                 150                 155                 160 


Ile Leu Ser Leu Arg Asp Asn Asp Leu Ile Ser Leu Pro Lys Glu Ile 
                165                 170                 175     


Gly Glu Leu Thr Gln Leu Lys Glu Leu His Ile Gln Gly Asn Arg Leu 
            180                 185                 190         


Thr Val Leu Pro Pro Glu Leu Gly Asn Leu Asp Leu Thr Gly Gln Lys 
        195                 200                 205             


Gln Val Phe Lys Ala Glu Asn Asn Pro Trp Val Thr Pro Ile Ala Asp 
    210                 215                 220                 


Gln Phe Gln Leu Gly Val Ser His Val Phe Glu Tyr Ile Arg Ser Glu 
225                 230                 235                 240 


Thr Tyr Lys Tyr Leu Tyr Gly Arg His Met Gln Ala Asn Pro Glu Pro 
                245                 250                 255     


Pro Lys Lys Asn Asn Asp Lys Ser Lys Lys Ile Ser Arg Lys Pro Leu 
            260                 265                 270         


Ala Ala Lys Asn Arg 
        275         


<210>  303
<211>  1663
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  304
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
1               5                   10                  15      


Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys 
            20                  25                  30          


Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg 
        35                  40                  45              


His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
    50                  55                  60                  


Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly 
65                  70                  75                  80  


Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                85                  90                  95      


Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
            100                 105                 110         


Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro Ser Leu Val Gly 
        115                 120                 125             


Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala Gly Leu Lys Glu 
    130                 135                 140                 


Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val Leu Thr Asn Lys 
145                 150                 155                 160 


Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu 
                165                 170                 175     


Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys 
            180                 185                 190         


Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu 
        195                 200                 205             


Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly 
    210                 215                 220                 


Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly 
225                 230                 235                 240 


Leu 
    


<210>  305
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Amino acid is a "heavy" amino acid of with +7 mass difference 
       relative to corresponding wild type amino acid owing to 
       incorporation of U-13C6, 15N isotopes

<400>  305

Asn Ile Pro Thr Val Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val 
1               5                   10                  15      


Asn Gln Leu Glu Lys 
            20      


